Neck lump Neck lump Fine-needle aspiration cytology (FNAC) is the first-line biopsy for the investigation of neck lymphadenopathy . This technique carries a sensitivity of 89–98%. It will help in di ff erentiating between thyroid malignancy , oropharyngeal and oral cavity lesions (utilising HPV diagnostic tests) and lymphoma. Neck lump Fine-needle aspiration cytology (FNAC) is the first-line biopsy for the investigation of neck lymphadenopathy . This technique carries a sensitivity of 89–98%. It will help in di ff erentiating between thyroid malignancy , oropharyngeal and oral cavity lesions (utilising HPV diagnostic tests) and lymphoma.