# Remodelling

Remodelling

The remodelling phase begins 2–3 weeks after injury and lasts for a year or more. This phase is characterised by maturation of  collagen. Type III collagen, which is prevalent during prolif eration, is replaced by stronger type I collagen until the normal skin ratio of  4:1 type I to type III collagen is re-established. The collagen becomes more cross-linked and uniformly aligned. This ma turation of  collagen leads to increased tensile strength in the wound, which is maximal 12 weeks post injury and represents approximately 80% of  the uninjured skin strength. - 

Hair Bacteria
Epidermis
Oxygen
Dermis
Subcutaneous
layer
Collagen Capillary
(c)
Collagen
(b)
Proliferation.
(c)
Remodelling. (Adapted by permission from Springer: Gurtner
Nature
2008;
453
: 314–21. 2008).

Remodelling

The remodelling phase begins 2–3 weeks after injury and lasts for a year or more. This phase is characterised by maturation of  collagen. Type III collagen, which is prevalent during prolif eration, is replaced by stronger type I collagen until the normal skin ratio of  4:1 type I to type III collagen is re-established. The collagen becomes more cross-linked and uniformly aligned. This ma turation of  collagen leads to increased tensile strength in the wound, which is maximal 12 weeks post injury and represents approximately 80% of  the uninjured skin strength. - 

Hair Bacteria
Epidermis
Oxygen
Dermis
Subcutaneous
layer
Collagen Capillary
(c)
Collagen
(b)
Proliferation.
(c)
Remodelling. (Adapted by permission from Springer: Gurtner
Nature
2008;
453
: 314–21. 2008).

Remodelling

The remodelling phase begins 2–3 weeks after injury and lasts for a year or more. This phase is characterised by maturation of  collagen. Type III collagen, which is prevalent during prolif eration, is replaced by stronger type I collagen until the normal skin ratio of  4:1 type I to type III collagen is re-established. The collagen becomes more cross-linked and uniformly aligned. This ma turation of  collagen leads to increased tensile strength in the wound, which is maximal 12 weeks post injury and represents approximately 80% of  the uninjured skin strength. - 

Hair Bacteria
Epidermis
Oxygen
Dermis
Subcutaneous
layer
Collagen Capillary
(c)
Collagen
(b)
Proliferation.
(c)
Remodelling. (Adapted by permission from Springer: Gurtner
Nature
2008;
453
: 314–21. 2008).