ICD 11

03 - Introduction

01 - A brief history of the CDDR
A brief history of the CDDR

02 - Intended users of the CDDR
Intended users of the CDDR
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
A brief history of the CDDR
ICD-6 (9) was the first version of the classification published by WHO, the first to contain
a classification of morbidity as well as mortality, and the first to include a classification of mental
disorders. In both ICD-6 and ICD-7 (10), the only information provided for mental disorders
was the code number and name for each diagnostic category, along with inclusion terms, which
specified some of the range of diagnostic concepts meant to be encompassed by the category.
Starting with ICD-8 (11), the WHO Department of Mental Health and Substance Use began to
provide additional information to assist with clinical implementation. In 1974, the Department
published a glossary of mental disorder terms and additional guidance related to the classification
of mental disorders (12), indicating that “unless some attempt is made to encourage uniformity of
usage of descriptive and diagnostic terms, very little meaning can be attributed to the diagnostic
side of statistics of mental illness based on the ICD and in many other ways communication
between psychiatrists will become increasingly difficult” (12, p. 12). Subsequently, brief definitions
were also included in the main, statistical version of the classification for all categories in the
mental disorders chapter in ICD-9 (13) and ICD-10 (14). (This innovation in the classification
of mental disorders in ICD-9 and ICD-10 has now been applied across the entire ICD-11 so that
the MMS contain brief descriptions for most categories in the classification.) However, according
to the WHO Department of Mental Health and Substance Use, these brief definitions were not
recommended for use by mental health professionals but rather were intended for use in health
statistics and in the coding of medical records and death certificates (15).
In 1992, the Department published a volume entitled The ICD-10 classification of mental and
behavioural disorders: clinical descriptions and diagnostic guidelines (CDDG) (15) concurrently
with the publication of the statistical version of ICD-10. The CDDG was “intended for general
clinical, educational, and service use” (15, p. 1). For each disorder, a description of the main
clinical and associated features was provided, followed by more operationalized diagnostic
guidelines that were designed to assist mental health clinicians in making a valid diagnosis.
The CDDR for ICD-11 represent an important advance in providing comprehensive practical
guidance on diagnosing mental disorders. A major improvement in the ICD-11 CDDR compared
to the ICD-10 CDDG is the consistency of structure and information across major categories,
based on reviews of the available evidence (16). The development of the CDDR has been guided
by the principles of clinical utility and global applicability. The information included is intended
to be useful to health professionals in making diagnostic judgements about individual patients,
including the features they can expect to see in all cases of a given disorder and how to differentiate
disorders from non-pathological expressions of human experience and from other disorders
including medical conditions. The CDDR describe additional clinical features that may be
present in some cases of a given disorder and provide key information that can assist in evaluating
diagnoses across cultures, genders and the lifespan. More information about the specific contents
and approach of the CDDR is provided in the next section on using the CDDR for ICD-11 mental,
behavioural and neurodevelopmental disorders in clinical settings. The reliability, clinical utility
and global applicability of the CDDR have been confirmed through a comprehensive programme
of developmental and evaluative field studies (6,17–19) that involved thousands of clinicians in all
global regions. This research programme is described in more detail later in this chapter.
Intended users of the CDDR
The CDDR are designed to be used by mental health professionals who are authorized by
training, scope of practice and applicable statute to provide diagnostic evaluations of people with
mental disorders (e.g. psychiatrists, psychologists in some countries). They are also intended to

03 - Development of the MMS and the CDDR for ICD 1
Development of the MMS and the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders
3
be useful to non-specialist health professionals (e.g. primary care physicians, nurses), who in
many countries provide a substantial proportion of total mental health services. They will also
be useful for other professionals in clinical and non-clinical roles who need to understand the
nature and symptoms of these disorders even if they do not personally diagnose them. Finally, the
CDDR are intended to provide students and trainees in variety of mental health and other health
fields with comprehensive guidance and information to support their development as competent
diagnosticians or interdisciplinary team members.
It is important to note that the organization of ICD-11 into chapters is not intended to reflect
the scope of practice of specific medical specialties or clinical professions. For example, mental,
behavioural and neurodevelopmental disorders and diseases of the nervous system are in separate
chapters, but WHO does not intend this as a statement that psychiatrists should not be allowed
to assess and treat headache disorders or that neuropsychologists should not be permitted to
evaluate which disease process may be causing a particular case of dementia given the pattern of
symptoms. Similarly, certain mental disorders (e.g. neurocognitive disorders such as dementia
or delirium, or dissociative disorders such as dissociative neurological symptom disorder
or dissociative amnesia), frequently come to the attention of a variety of health professionals
(e.g. primary care physicians, neurologists) who may be equipped to evaluate and diagnose them
using the CDDR as a guide.
Health-care professionals using the CDDR to make diagnoses should be qualified to do so by
their clinical training and experience, and are expected to have the necessary clinical expertise
and understanding of mental disorders to identify symptoms and to distinguish disorders from
normal variation, from one another, and from transient responses to stress or environmental
circumstances. The CDDR are written to allow for the exercise of clinical judgement, and it is
the diagnosing health professional who is responsible for developing a diagnostic formulation
appropriate for an individual patient, considering the patient’s individual, social and cultural
context as well as the characteristics of the health system. It is equally important to note that
diagnostic classification is only a part of patient assessment. The CDDR are not a guide to patient
care, nor a comprehensive textbook of psychiatry, nor a manual of how to conduct clinical
assessments and differential diagnoses. The focus of the CDDR is on the classification of disorders
and not the assessment and treatment of people, who are frequently characterized by multiple
disorders and diverse needs (5).
Development of the MMS and the CDDR for ICD-11 mental,
behavioural and neurodevelopmental disorders
As noted above, the WHO Department of Mental Health and Substance Use led the development
of the ICD-11 chapter on mental, behavioural and neurodevelopmental disorders, including
both the MMS and the CDDR. Over the course of more than a decade, the Department
coordinated an intensive, systematic, international process that involved a wide range of key
stakeholder groups including scientific and public health experts, clinicians, representatives of
WHO Member States, scientific and professional societies, service users and their carers, and
other nongovernmental organizations. All expert contributors to this document were asked to
complete a WHO Declaration of Interests (DoI) form prior to their contribution. Once received,
the WHO Secretariat reviewed the DoI forms and evaluated whether there were any conflicts of
interest and, if so, whether these required a management plan. Prior to the finalization of this
document, all contributors were asked to complete another DOI form. No conflicts of interest
requiring a management plan were identified.
Introduction
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Formation of the ICD-11 International Advisory Group
In 2007, the WHO Department of Mental Health and Substance Use appointed the International
Advisory Group for the Revision of ICD-10 Mental and Behavioural Disorders (5), comprising
scientific experts from all WHO regions and representatives from relevant international scientific
societies. This Advisory Group was tasked with scientific oversight for the entire revision process.
Its specific functions were to advise WHO on the key guiding principles and goals of the revision,
the steps involved in the revision, and identification of other groups of relevant consultants and
stakeholders required to develop the classification of mental disorders and other relevant parts
of ICD-11; and to facilitate the implementation of global field studies to assess and improve the
revisions to ICD-11 and the CDDR. The Advisory Group also functioned as one of approximately
30 topic advisory groups for the overall development of ICD-11, each focusing on a different area
or cross-cutting theme (e.g. gastroenterology, ophthalmology, quality and safety) and represented
on the Revision Steering Committee – working with the WHO Classifications and Terminology
and Data Standards Team responsible for coordinating the overall effort.
Development of the CDDR by ICD-11 working groups
The International Advisory Group advised the WHO Department of Mental Health and Substance
Use on the appointment of more than a dozen working groups tasked with reviewing the
relevant evidence and making proposals for changes to the structure and content of the ICD-10
classification of mental, behavioural and neurodevelopmental disorders. Most of the working
groups were established in relation to a particular subset of mental disorders (e.g. psychotic
disorders, mood and anxiety disorders, personality disorders). Others were appointed to make
proposals regarding how cross-cutting themes (e.g. presentations in children and adolescents,
presentations in older adults, cultural factors) would be handled in the CDDR. Members of the
working groups were expert multidisciplinary mental health professionals with relevant scientific
and/or clinical expertise. The working groups were constituted such that experts from all WHO
regions were included, with substantial representation from low- and middle-income countries.
The working groups’ charge included reviewing the extant body of basic science, clinical and public
health research relevant to their area of responsibility for use as a basis for their recommendations
for revisions to the classification of mental disorders in ICD-10. The working groups used these
reviews to recommend changes to enhance the validity of ICD-11 (e.g. addition or deletion
of categories, changes in thresholds or diagnostic requirements). They also reviewed available
evidence related to the clinical utility of proposed changes, such as whether the revised diagnostic
descriptions would enhance the identification of individuals who need mental health services or
their usefulness in treatment and management decisions in a range of global health-care settings,
particularly in low- and middle-income countries. Working groups proposed specific changes to
the structure of the classification of mental disorders in ICD-11; what categories and specifiers
were included; and the MMS brief descriptions and the CDDR for the area under their purview.
They were asked to provide the rationale, evidence base and expected impact on clinical utility of
any proposed change via a structured, documented process (16).
Working groups were instructed to emphasize considerations of clinical utility and global
applicability in developing their recommendations. Clinical utility is important because health
classifications represent the interface between health encounters and health information. A system
that does not provide clinically useful information at the level of the health encounter will not
be faithfully implemented by clinicians. In that case, data aggregated from health encounters
will not be optimal and perhaps not even valid, affecting the usefulness and validity of summary
health encounter data used for decision-making at the health system, national and global level.
The WHO Department of Mental Health and Substance Use operationalized the clinical utility
5
of a category in the ICD-11 chapter on mental, behavioural and neurodevelopmental disorders
as depending on:
• its value in communicating (e.g. among practitioners, patients, families, administrators);
• its implementation characteristics in clinical practice, including its goodness of fit
(i.e. accuracy of description), its ease of use and the time required to use it (i.e. feasibility);
• and its usefulness in selecting interventions and in making clinical management decisions.
Global applicability was addressed via the diverse global membership of the working groups and
by the international nature of the field studies implemented as part of the development of the
CDDR, and by specific attention to culture as a part of the CDDR (see the sections on public
review and field testing and on cultural factors below).
In order to generate relatively uniform information and a consistent structure across groupings
and categories of the CDDR (see the next section on using the ICD-11 classification of mental,
behavioural and neurodevelopmental disorders in clinical settings), working groups collated
diagnostic information using a standardized template (referred to as a “content form”), with
relevant references. This information served as source material for the development of the
CDDR, with the final editorial responsibility vested in the WHO Department of Mental Health
and Substance Use. The brief descriptions in the MMS and the more detailed essential features
in the CDDR were developed together in order to be fully compatible, though designed for
different purposes. The MMS brief descriptions are typically summaries of the essential features
for the corresponding entity in the CDDR, although these brief descriptions alone do not provide
sufficient information for implementation in clinical settings.
Public review and field testing
Proposals developed by working groups were described in the scientific literature (e.g. 20–26),
made available for public review (27), and tested via a systematic programme of global field
studies (see the section on field studies below). Scientific oversight for the field studies was
provided by the ICD-11 Field Studies Coordination Group (FSCG) (28), comprising global
leaders in clinical care, scientific research and public health representing all WHO regions, with
substantial representation from low- and middle-income countries. FSCG members not only lent
their technical expertise to the design, analysis and interpretation of the field studies but also
served as essential facilitators by successfully engaging global clinicians to participate in ICD-11
field studies around the world. Many of them directed international field study centres, which
conducted field studies in routine clinical settings with real patients. The FSCG and relevant
working groups were also involved in proposing changes to the CDDR based on the results of the
field studies (17).
WHO’s comprehensive programme of field testing to assess the reliability, clinical utility and
global applicability of the proposed CDDR was a major area of innovation, employing novel study
designs and new methodologies for collecting information. Global participation was a defining
characteristic of the ICD-11 CDDR field studies, which engaged multidisciplinary clinicians
working in diverse contexts across the world, and were conducted in multiple languages. A key
strength of the research programme was that studies were conducted within a time frame that
allowed the results to be used as a basis for further revision of the CDDR prior to publication.
Early in the revision process, two major international, multilingual surveys were conducted – one
of psychiatrists, conducted in collaboration with the World Psychiatric Association (29) and the
other of psychologists, conducted in collaboration with the International Union of Psychological
Science (30). These surveys focused on participants’ use of diagnostic classification systems in
clinical practice, and the desirable characteristics of a classification of mental disorders. The
professionals overwhelmingly preferred more flexible guidance to allow for cultural variation
Introduction
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
and clinical judgement compared to a strict criteria-based approach, and were receptive to a
system incorporating a dimensional component. Respondents described a number of categories
as having poor clinical utility in practice, while others were recommended for addition or
deletion (31,32). These data were used in the initial decisions about the content of the CDDR and
in the development of diagnostic guidance by working groups.
In order to provide data to assist in developing an organizational structure that would be more
clinically useful, two formative field studies were conducted to examine the conceptualizations
held by mental health professionals around the world regarding the structure of mental disorders
and the relationships among them (33,34). These data showed a high degree of similarity across
countries, languages and regions, regardless of the classification system participants used in
clinical practice, and informed decisions about the structure of the classification.
The proposed CDDR material was then tested in two main sets of evaluative field studies:
case-controlled (internet-based) and ecological implementation (clinic-based) field studies.
The case-controlled studies assessed the clinical utility of the proposed diagnostic material;
most compared how global clinicians applied the proposed ICD-11 material versus the ICD-10
diagnostic guidelines for a given diagnostic area in terms of accuracy and consistency of clinicians’
diagnostic formulations, using a scientifically rigorous vignette-based methodology (17,35).
Other studies examined scaling for diagnostic specifiers (36) and how clinicians actually used
classifications in their clinical practice (37), including how they combined multiple dimensions
in making a categorical diagnosis (38).
Case-controlled studies were conducted in between three and six languages – Chinese, English,
French, Japanese, Spanish and Russian – per study, with participation from thousands of
clinicians from across the globe who were members of WHO’s Global Clinical Practice Network.
The Network’s field studies have assessed a wide range of disorder groupings (e.g. 39–45).
Two internet-based studies comparing ICD-11 to ICD-10 were also conducted in German (46,47).
Overall, these studies have demonstrated incrementally superior – or in some cases equivalent –
performance of the ICD-11 CDDR compared to the ICD-10 CDDG in the accuracy of diagnoses
assigned to case vignettes by participating clinicians, as well as improvements in ratings of clinical
utility. When a clinician’s diagnoses did not follow the expected pattern, the study methodology
allowed for examination of which specific features of the diagnostic requirements accounted for
underperformance, which in turn permitted modifications to the CDDR to address points of
ambiguity or misunderstanding (e.g. 39,44). These studies also included analyses of results by
region and language to identify potential difficulties in global or cultural applicability, as well as
problems in translation. In addition to refining the CDDR, data from these studies have provided
useful information for the development of training programmes on the new ICD-11 diagnostic
material. For example, the German study examining performance on a coding task suggested a
substantial need for training initiatives to support the use of ICD-11 by professional coders (47).
Two major ecological implementation (clinic-based) field studies were conducted. The first
tested the proposed CDDR diagnostic material when applied by practising clinicians to adult
patients receiving care in the types of clinical settings in which the CDDR will be implemented
(18,19). The study was conducted in 14 countries – Brazil, Canada, China, Egypt, India, Italy,
Japan, Lebanon, Mexico, Nigeria, the Russian Federation, South Africa, Spain and Tunisia – via a
network of international field study centres. The study assessed the reliability and clinical utility
of the CDDR for disorders that account for the highest percentage of global disease burden and
use of mental health services in clinical settings among adults: schizophrenia and other psychotic
disorders, mood disorders, anxiety and fear-related disorders, and disorders specifically
associated with stress. A joint-rater reliability methodology, in which two clinicians were present
during the patient interview but reported their diagnostic formulation and clinical utility ratings
7
independently, was employed in order to isolate the effects of the CDDR from other sources of
variance in diagnosis (e.g. changes over time, inconstancy in reporting). Importantly, the level
of training on the ICD-11 CDDR received by participating clinicians was similar to what might
be expected in routine clinical setting during ICD-11 implementation. Clinicians were given no
instructions on how to conduct their diagnostic interviews other than to assess the areas that
were required as part of the study protocol. Overall, intraclass kappa coefficients (a measure of
reliability between raters) for diagnoses weighted by site and study prevalence ranged from 0.45
(dysthymic disorder) to 0.88 (social anxiety disorder). The reliability of the ICD-11 diagnostic
requirements was superior to that previously reported for equivalent ICD-10 guidelines (18).
Clinician ratings of the clinical utility of the ICD-11 CDDR were very positive overall. The
CDDR were perceived as easy to use, accurately reflecting patients’ presentations (i.e. goodness
of fit), clear and understandable, and no more time-consuming than the clinicians’ standard
practice (19).
A separate study of common child and adolescent diagnoses was conducted in four countries –
China, India, Japan and Mexico – with children and adolescents from 6 to 18 years of age (48).
The study focused on attention deficit hyperactivity disorder, disruptive behaviour and dissocial
disorders, mood disorders, anxiety and fear-related disorders, and disorders specifically associated
with stress, using a design that was analogous to the adult study. Kappa estimates indicated
substantial agreement for most categories, with moderate agreement for generalized anxiety
disorder and adjustment disorder. No differences were found between younger (6–11 years) and
older (12–18 years) age groups, or between outpatient and inpatient samples. Clinical utility
ratings for these diagnoses were positive and consistent across the domains assessed, although
they were somewhat lower for adjustment disorder. Taken together, the results of the ecological
implementation studies supported the implementation of the ICD-11 CDDR in clinical settings,
and suggested that the results of the case-controlled studies were generalizable to clinical settings.
Another clinic-based field study in three countries examining the novel behavioural indicators
for the assessment of the severity of ICD-11 disorders of intellectual development found them
to have good to excellent levels of inter-rater reliability, concurrent validity and clinical utility.
This supported their use to assist in the accurate identification of individuals with disorders
of intellectual development, particularly in settings where specialized assessment services are
unavailable (49).
A separate field studies programme to test the section of the ICD-11 CDDR on disorders due to
substance use and addictive behaviours involved field testing centres in 11 countries: Australia,
Brazil, China, France, Indonesia, India, the Islamic Republic of Iran, Malaysia, Mexico, Switzerland
and Thailand. The main aim of the studies was to explore the public health and clinical utility,
feasibility and stability (comparability with ICD-10) of the proposed CDDR for disorders due
to the use of psychoactive substances, as well as the newly designated subgrouping of disorders
due to addictive behaviours (i.e. gambling disorder and gaming disorder). The mixed-methods
approach used in these studies included key informant surveys and interviews, focus groups
and consensus conferences at each study site. Across sites, more than 1000 health professionals
participated in the survey, more than 200 participants were involved in 30 focus groups organized
at the study sites, and 42 identified national experts in the field reviewed the draft CDDR.
Overall, this section of ICD-11 was judged to be major step forward compared to ICD-10 in
terms of its utility for meeting clinical and public health, and its feasibility for implementation.
There was broad support for major innovations in this area. For disorders due to substance use,
this included the expansion of substance classes to reflect evolving patterns in global psychoactive
substance use (e.g. synthetic cannabinoids, MDMA1 or related drugs), the introduction of new
categories to capture episodes of harmful substance use, and the inclusion of the concept of “harm
to health of others” in the definition of harmful substance use (25). There was also support for
3,4-methylenedioxy-methamfetamine, also known as “ecstasy”.
Introduction
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
integrating disorders due to addictive behaviour in the same overarching grouping as disorders
due to substance use, and for the introduction of the new diagnostic category gaming disorder. At
the same time, the field study results highlighted the overall increase in complexity of this part of
ICD-11 and the need for training of health professionals in order to ensure a smooth transition.
The field studies also yielded specific suggestions for better delineation of the boundaries among
some diagnostic categories as well as better descriptions of new ones.
In addition, WHO commissioned a study (50) on the concordance among diagnoses for alcohol
and cannabis use disorders based on ICD-11, ICD-10 and the Diagnostic and Statistical Manual
of Mental Disorders, fourth and fifth editions (DSM-IV and DSM-5) (51,52). The results of
the study demonstrated high concordance among the populations identified by the ICD-11
diagnostic requirements compared to ICD-10 and DSM-IV. Concordance of between ICD-11
and DSM-5 was substantially lower, in large part due to low agreement between the diagnoses of
harmful pattern of alcohol use and harmful pattern of cannabis use in ICD-11 and mild alcohol
use disorder and mild cannabis use disorder in DSM-5.
Development of the CDDR also included the involvement of mental health service users and
carers through two studies in 15 countries representing diverse clinical contexts in multiple
global regions (53,54). These studies constituted the first instance of a systematic research
programme studying mental health service users’ perspectives during the revision of a major
diagnostic classification system. The studies employed participatory research methodologies to
systematically collate service user perspectives on key CDDR diagnoses that contribute to high
disease burden, including schizophrenia, depressive episode, bipolar type I disorder, generalized
anxiety disorder and personality disorder. Findings from these studies provided an understanding
of how mental health service users respond to diagnostic content of the CDDR, and served
as a basis for providing recommendations to WHO about potential enhancements of CDDR
diagnostic material that may enhance its clinical utility (e.g. its usefulness in communicating
with service users) and mitigating potential unintended negative consequences of the diagnostic
material, including stigmatization of diagnosed individuals.
Coordination with the development of DSM-5
The development of ICD-11 overlapped with the development and publication of DSM-5 (52).
The Chair and Co-Chair of the DSM-5 Task Force regularly attended meetings of the Advisory
Group in an effort to facilitate “harmonization” of the two classifications. This was most successful
in terms of the way that mental disorders are divided into groupings and how those groupings are
ordered in the two classifications (referred to as the “metastructure”). In this regard, ICD-11 and
DSM-5 are quite similar to one another, though not identical, and substantially different from ICD10 and DSM-IV. Most ICD-11 working groups included at least one member of the corresponding
DSM-5 workgroup. ICD-11 working groups were asked to consider the clinical utility and global
applicability of material being developed for DSM-5, with the goal of minimizing unintentional or
arbitrary differences between the two systems. Intentional conceptual differences were permitted,
however, and the working groups were asked to provide a justification for such differences where
they were proposed. The differences between ICD-11 (both the MMS and the CDDR) and DSM-5
are therefore conscious and intentional (16,55), and a number of such differences have stimulated
valuable research that has enhanced our knowledge about psychopathology (56).

04 - Key approaches to classifying mental, behavio
Key approaches to classifying mental, behavioural and neurodevelopmental disorders
9
Key approaches to classifying mental, behavioural and
neurodevelopmental disorders
The definition of mental, behavioural and neurodevelopmental disorders
The ICD-11 chapter on mental, behavioural and neurodevelopmental disorders begins with the
following definition:
Mental, behavioural and neurodevelopmental disorders are syndromes characterized by clinically
significant disturbance in an individual’s cognition, emotional regulation or behaviour that
reflects a dysfunction in the psychological, biological or developmental processes that underlie
mental and behavioural functioning. These disturbances are usually associated with distress
or impairment in personal, family, social, educational, occupational or other important areas
of functioning.
The term “disorder” is used as a part of nearly all category titles in the chapter. Although “disorder”
is not a precise term, as in ICD-10 its use is intended “to avoid even greater problems inherent
in the use of terms such as ‘disease’” (15, p. 11), which implies greater certainty about etiology
and pathophysiology than exists for most mental disorders. Although mental disorders are by
definition syndromes, “syndrome” is a broader term with more variable usage. Its use in category
titles in the classification of mental, behavioural and neurodevelopmental disorders is restricted
to the grouping of secondary mental or behavioural syndromes associated with disorders and
diseases classified elsewhere; these are conditions with more variable symptoms that are less
specified in the CDDR, but are judged to be direct pathophysiological consequences of a medical
condition. Other conditions referred to as syndromes that are mentioned in the CDDR are
classified in other parts of ICD-11 (e.g. Tourette syndrome is included in the chapter on diseases
of the nervous system).
Beyond the issue of terminology, the definition of mental, behavioural and neurodevelopmental
disorders helps to delineate two boundaries. The first is the boundary between mental, behavioural
and neurodevelopmental disorders and diseases and disorders classified in other chapters of
ICD-11, and the second is the boundary between mental, behavioural and neurodevelopmental
disorders and normality. Both of these boundaries represent key issues in diagnosis. The first
part of the definition (“clinically significant disturbance in an individual’s cognition, emotional
regulation or behaviour”) indicates that the essential features of the disorders included in the
ICD-11 chapter on mental, behavioural and neurodevelopmental disorders invariably involve
(but are not limited to) symptoms from these domains of mental and behavioural functioning.
The presentation of disorders in other ICD-11 chapters (e.g. those on diseases of the nervous
system and sleep-wake disorders) may include disturbances in these domains, but they are not
common to all the disorders in those chapters.
The second part of the definition is intended to clarify that in order for a clinical presentation to be
diagnosable as a mental, behavioural or neurodevelopmental disorder (as opposed to representing
normal variation), the symptom must reflect a dysfunction in an underlying psychological,
biological or developmental process. For example, the experiences of an individual who has
recently been bereaved might include acute feelings of sadness and emptiness accompanied
by disturbances in cognition, emotional regulation or behaviour. However, symptoms entirely
attributable to grief are not in and of themselves indicative of an underlying dysfunction in a
psychological, biological or developmental process. Normal bereavement is not considered to be
a disorder, despite its potential negative impact on social and occupational functioning. Similarly,
behaviour (e.g. political, religious, sexual) that deviates from the accepted standards of society is
only considered to be symptomatic of a mental disorder if it is a manifestation of a dysfunction in
a psychological, biological or developmental process.
Introduction
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
The final part of the definition (“these disturbances are usually associated with distress or
impairment in personal, family, social, educational, occupational or other important areas of
functioning”) notes that distress in the individual and/or impairment in functioning is commonly
a consequence of the symptoms, and for many mental disorders is an essential feature. At the
same time, it is not always required (e.g. individuals experiencing a hypomanic episode in the
context of bipolar type II disorder often do not experience distress about their condition, and
by definition do not exhibit functional impairment), hence the use of “usually” in the definition.
Structure of the chapter on mental, behavioural and neurodevelopmental
disorders
The organization of the ICD-10 chapter on mental and behavioural disorders had been dictated
in part by the ICD-10 coding system itself. The first character of ICD-10 codes, which indicated
the chapter, was alphabetical, thus allowing for up to 26 chapters. The second character, which
indicated the diagnostic grouping within the chapter, was numerical, effectively limiting the
number of possible diagnostic groupings within a chapter to 10. The use of alphanumeric characters
throughout the ICD-11 coding system removes those artificial constraints. Consequently, there are
21 diagnostic groupings in the ICD-11 chapter on mental, behavioural and neurodevelopmental
disorders. A few of the ICD-11 diagnostic groupings are completely parallel to ICD-10 groupings
(e.g. disorders due to substance use, schizophrenia and other primary psychotic disorders, mood
disorders). Most of the other ICD-10 diagnostic groupings were split into multiple ICD-11
groupings. For example, ICD-10 neurotic, stress-related and somatoform disorders was split into
five ICD-11 diagnostic groupings: anxiety and fear-related disorders; obsessive-compulsive and
related disorders; disorders specifically associated with stress; dissociative disorders; and bodily
distress disorders.
In one case, three ICD-10 diagnostic groupings (mental retardation; disorders of psychological
development; and behavioural and emotional disorders with onset usually occurring in childhood
and adolescence) were combined into a single neurodevelopmental disorders grouping in ICD-11,
although some of the disorders that were included in the behavioural and emotional disorders
with onset usually occurring in childhood and adolescence grouping in ICD-10 were placed into
other ICD-11 diagnostic groupings based on symptomatic presentations (e.g. conduct disorders
were placed in the disruptive behaviours or dissocial disorders grouping in ICD-11). Disorders of
intellectual development in ICD-11 have been reconceptualized from ICD-10 mental retardation
such that they are assessed based on adaptive behaviour functioning in addition to intellectual
functioning.
The elimination of ICD-10 diagnostic groupings explicitly linked to onset of the condition during
childhood and adolescence is in part related to the decision to adopt a lifespan approach to the
description of diagnostic categories in ICD-11. Each category contains a section on developmental
presentations, which describes the manifestations of the disorder in early and middle childhood,
adolescence and older adulthood, to the extent possible based on available evidence. The ICD-11
CDDR also include descriptions of adult presentations of most disorders described exclusively in
terms of children in the ICD-10 CDDG (e.g. attention deficit hyperactivity disorder, separation
anxiety disorder, conduct disorder, pica).
Four diagnostic subgroupings were moved out of the mental, behavioural and neurodevelopmental
disorders chapter entirely and placed within other ICD-11 chapters: ICD-10 nonorganic sleep
disorders were moved to the ICD-11 chapter on sleep-wake disorders, ICD-10 sexual dysfunctions
not caused by organic disorder or disease and gender identity disorders were moved to the
ICD-11 chapter on conditions related to sexual health, and ICD-10 tic disorders were moved to
the ICD-11 chapter on diseases of the nervous system. The movement of sleep-wake disorders
and sexual dysfunctions to new, separate chapters in no way indicates that these conditions are
11
not appropriately treated by mental health professionals. Rather, it reflects an effort to remove
the artificial and scientifically and clinically inaccurate “mind–body split” embodied in the
designation of “organic” and “nonorganic” forms of these disorders. The inclusion of ICD-11
gender incongruence in the chapter on conditions related to sexual health reflects the conclusion
that these conditions are not appropriately viewed as mental disorders based on a series of
international field studies indicating that distress and functional impairment in transgender
people is predicted by experiences of stigmatization and victimization rather than being an
intrinsic characteristic of being transgender (57–59).
Categories and dimensions
ICD-10 was almost entirely categorical in nature (categories were either present or absent), with
the only exceptions being severity-based subcategories for mental retardation (mild, moderate,
severe, profound) and depressive episode (mild, moderate, severe). ICD-11 has moved beyond a
strictly categorical approach, incorporating dimensional elements in two different ways. First, in
addition to intellectual developmental disorder and depressive episode, bodily distress disorder,
personality disorder and dementia are subcategorized based on severity (mild, moderate, severe).
Second, a number of mental disorders allow for the indication of symptomatic manifestations
that are intended to provide dimensional profiles that cut across different disorders in a
particular grouping. These include symptomatic manifestations of primary psychotic disorders
(positive symptoms, negative symptoms, depressive mood symptoms, manic mood symptoms,
psychomotor symptoms, cognitive symptoms), which can be further coded as not present, mild,
moderate or severe, and prominent personality trait domains in personality disorders (negative
affectivity, detachment, asociality, disinhibition, anankastia). See the following section on using
the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
for specific examples of how these dimensional specifiers are coded.
Cultural factors
Because the CDDR will be employed around the world as a basis for diagnosis and treatment
selection among people living in diverse social milieus and cultural contexts, a key priority in
development of the diagnostic material was to consider and reflect the influence of culture.
Cultural factors affect the diagnosis of mental, behavioural and neurodevelopmental disorders
in complex and multifaceted ways. For example, culture can influence how disorders are
conceptualized, experienced and expressed; what is considered normal or pathological; how
functioning is affected; where and how people seek care; and the ways that patients and families
participate in treatment. Attention to culture was also in line with the overall priority of the
revision process to enhance the clinical utility and global applicability of the CDDR. Information
that makes the diagnostic system more relevant and acceptable to clinicians and service users
around the world can enhance the usefulness of the CDDR as tool for identifying those who
require care and connecting them to services.
WHO appointed a Working Group on Cultural Considerations to develop material on culture
for the CDDR. This Working Group conducted extensive consultations with experts from
around the world, and systematically reviewed the literature on cultural influences on diagnosis
and psychopathology for each diagnostic category, as well as relevant material on culture from
ICD-10 and DSM-5. Information was also collated from materials produced by other ICD-11
working groups as part of their generation of proposed content for their respective diagnostic areas.
On this basis, the Working Group developed a section entitled “culture-related features” for
diagnostic categories in the CDDR. The focus was on providing pragmatic, actionable material
to assist clinicians in using the CDDR to evaluate patients in a culturally informed manner and
reduce bias in clinical decision-making. This section is meant to be of practical use in the process
Introduction

05 - Using the CDDR in research
Using the CDDR in research
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
of engagement, diagnosis, evaluation and treatment selection, and addresses the following areas:
• cultural variation in prevalence and symptoms of disorders;
• information about social contexts and sociocultural mechanisms that may account for this
variation; and
• descriptions of cultural concepts of distress (e.g. idioms, causal explanations) that are relevant
to diagnosis and treatment decisions, prioritizing cultural variations that may be associated
with national or ethnocultural background (60,61).
The resulting guidance aims to assist the clinician in making informed decisions likely to foster
more contextually applicable patient-centred care that is sensitive to the cultural and social milieu
of the clinical encounter.
For example, the section on culture-related features of the CDDR for panic disorder indicates
that the symptom presentation of panic attacks may vary across cultures, and describes several
notable cultural concepts of distress that link panic, fear or anxiety to cultural attributions
regarding specific social and environmental influences. Understanding these attributions can
assist in differential diagnosis and can also clarify whether panic attacks should be considered
expected or unexpected (as is required for a diagnosis of panic disorder) given the environmental
circumstances.
The development of the CDDR incorporated cultural considerations in several other ways. First,
global applicability of diagnostic material was identified early on as an overarching objective of the
CDDR, and the development process was led and guided by experts and clinicians representing
all major global areas. The Advisory Group, the FSCG and all working groups included members
with diverse geographical and linguistic backgrounds, many of whom had direct experience
working in low-resource contexts and within various cultures.
The design and implementation of ICD-11 field studies also adhered to the principle of enhancing
the global and cultural applicability of the CDDR by engaging thousands of clinicians from around
the world in a comprehensive research programme to assess the reliability, clinical utility and
global applicability of the requirements. For example, the formative studies that helped to shape
the architecture and linear structure of the CDDR involved clinicians from over 40 countries and
were conducted in multiple languages. The evaluative case-controlled studies engaged clinicians
in large-scale, multilingual studies related to major diagnostic areas of the CDDR. The clinicians
who participated in the case-controlled studies were members of the Global Clinical Practice
Network (62), which now includes more than 18  000 mental health professionals from over
160 countries, and was established by WHO for the purposes of assisting in the development of
ICD-11 by its members participating in internet-based field studies. Similarly, clinic-based field
studies testing the implementation of the CDDR with real patients took place in over 25 study
sites in 14 culturally, linguistically and geographically diverse countries. Hundreds of clinicians in
these countries provided feedback directly on the CDDR to help enhance its reliability and utility
in culturally diverse global settings.
Using the CDDR in research
In addition to the ICD-10 CDDG, the WHO Department of Mental Health and Substance Use
published The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for
research (DCR) (63) as a companion document. The DCR presented fully operationalized criteria
for ICD-10 mental disorder entities, specifically intended for use in research. These criteria
were designed to replace the “diagnostic guidelines” portion of the corresponding category in
the CDDG, which tended to be more flexible and less fully operationalized. The core criteriabased approach taken in the DCR was therefore much more compatible with the approach of
13
DSM-IV (51), although substantial differences between the two systems remained (64). However,
almost no research using the ICD-10 DCR appears to have been published.
The greater standardization and the provision of a broader and more systematic range of clinically
relevant information in the ICD-11 CDDR compared to the ICD-10 CDDG (16) was designed
to make the CDDR more useful in clinical decision-making, and therefore also in education
and training. The extremely high ratings of the clinical utility of the CDDR, particularly in
international clinic-based field studies with real patients (19,48) suggest that this objective was
achieved. Moreover, the solid reliability results from the ICD-11 field studies (18,48) indicate that
the CDDR would be satisfactory for use in certain kinds of research projects – for example, projects
focused on individuals with particular diagnoses as these are assigned in health-care settings (e.g.
patients diagnosed with recurrent depressive disorder receiving services at a particular facility).
However, in other types of research projects, in which obtaining reproducible and precise
psychiatric diagnoses is more important, standardized diagnostic assessment procedures are
necessary. This is meant to control variability inherent in diagnostic processes that rely on the
interviewer’s diagnostic interviewing skills (different interviewers may ask different questions to
assess the same clinical phenomena) and clinical judgement (different interviewers may arrive at
different diagnostic conclusions). For example, studies of the efficacy of treatments for particular
disorders require consistency in diagnostic procedures to ensure that the population being studied
has been assigned the diagnosis for which the treatment is intended according to consistent and
explicit diagnostic rules to reduce random diagnostic heterogeneity. Similarly, epidemiological
studies that utilize lay (i.e. not clinically trained) interviewers to apply the ICD-11 CDDR require
pre-scripted questions and strict decision rules because they cannot rely on the clinical expertise
of the interviewer to make judgements about which features are present. For these reasons, several
WHO-sponsored diagnostic instruments are being developed to facilitate the application of the
ICD-11 CDDR in particular research settings.
The Structured Clinical Interview for ICD-11 (SCII-11) is a semi-structured diagnostic interview
that requires experience in clinical interviewing on the part of the interviewer. The SCII-11 is
designed to be used in conjunction with the CDDR, and provides a standardized set of questions
to assist researchers to elicit the information needed to conduct a differential diagnosis in the
context of research studies. It will also be useful for training purposes and in clinical settings.
The development of the SCII-11 required extensive decisions about operationalizing the CDDR
so that they can be more reliably applied in research settings. The SCII-11 operationalized the
CDDR in two different ways: by substituting more precise diagnostic thresholds and by the choice
of wording of corresponding interview questions. The CDDR intentionally avoid artificially
precise duration and symptom cutoffs, allowing clinicians more flexibility for clinical judgement.
The SCII-11 modifies some of the CDDR items, substituting more precise thresholds. For
example, the ICD-11 CDDR for panic disorder define a panic attack as follows: “Panic attacks are
discrete episodes of intense fear or apprehension also characterized by the rapid and concurrent
onset of several characteristic symptoms. These symptoms may include, but are not limited to,
the following…” The SCII-11 has modified this item, substituting the word “several” with “at
least three”. Similarly, the CDDR incorporate many broadly defined diagnostic constructs that
could be assessed in different ways. Rather than relying on the interviewer to decide the best
way to assess them, the SCII-11 operationalizes diagnostic constructs through the specificity
and wording of corresponding interview questions. For example, the CDDR for schizophrenia
require the presence of at least two items from a list of seven, most of the time for a period of 1
month, with one of the seven being “persistent delusions (e.g. grandiose delusions, delusions of
reference, persecutory delusions)”. Since there is no single question that can satisfactorily cover
every type of delusion, the SCII-11 divides the assessment of delusions into separate questions
corresponding to specific types of delusions (e.g. delusions of reference, persecutory delusions,
Introduction
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
grandiose delusions, delusions of guilt, somatic delusions). Given that it is a semi-structured rather
than a fully structured interview, the interviewing clinician also has the option of following up
on particular responses or asking additional questions in order to assess the relevant phenomena
fully. WHO plans to make available a list of the operational decisions implemented in the SCII-11
as a resource in the development of other instruments to encourage greater cross-instrument
agreement.
In addition, WHO is developing a fully structured diagnostic interview to be used in
epidemiological studies and in other situations in which the SCII-11 is not feasible owing to
time constraints or because it is not feasible to use trained clinicians as interviewers. The Flexible
Interview for ICD-11 (FLII-11) covers common and high-burden mental disorders, but is less
comprehensive than the SCII-11. It is based on the algorithms and operationalizations developed
for the SCII-11 but consists entirely of closed-ended (primarily yes/no questions), and is designed
for use by lay interviewers with a limited amount of training. It will also be available for electronic
administration as an open-access tool for WHO member states.
The Schedules for Clinical Assessment in Neuropsychiatry (SCAN) (65,66) is a semi-structured
clinical interview used by trained clinicians to assess and diagnose mental disorders among
adults, originally developed as a part of a joint project of WHO and the United States National
Institute of Mental Health. The SCAN comprises a set of instruments, supported by manuals,
and was originally developed around the Present State Examination, which assesses a wide range
of symptoms likely to be manifested during a psychotic episode. The SCAN is designed to yield
both ICD and DSM diagnoses, and has been translated into more than 35 languages. It requires
extensive training by an approved training centre to administer. Its approach is different from
that of the SCII-11, which attempts to assess the diagnostic requirements of mental disorders
more directly via direct self-report of their essential features. Version 3 of the SCAN is currently
being developed and will be fully compatible with the ICD-11. It will refer to the SCII-11
operationalizations in the formulation of its diagnostic algorithms, although its assessment
methodology will remain distinct.
In addition, instruments focused on particular diagnoses as formulated in ICD-11 are being
developed by WHO as well as by researchers external to WHO. For example, WHO is supporting
the development of screening and diagnostic tools for gaming disorder (67). Instruments not
sponsored by WHO include several measures of personality disorder severity and trait domains
based on ICD-11 developed by different research groups (68–71). A self-report measure of
ICD-11 post-traumatic stress disorder and complex post-traumatic stress disorder has been
validated (72) and translated into over 25 languages. A scale designed to assess ICD-11 compulsive
sexual behaviour disorder has been developed and validated (73), and will be made available in
up to 30 languages as part of a large international research project (74). Ultimately, the use of the
ICD-11 classification of mental, behavioural and neurodevelopmental disorders in research will
depend on the development of validated measures for specific purposes, as illustrated by these
examples, rather than on the development of a separate classification intended for research use.

06 - Conclusion
Conclusion
15
Conclusion
As stated by the Advisory Group early in the development of ICD-11, “People are only likely to have
access to the most appropriate mental health services when the conditions that define eligibility
and treatment selection are supported by a precise, valid, and clinically useful classification
system” (5, p. 90). The ICD-11 classification of mental, behavioural and neurodevelopmental
disorders and the CDDR have taken major steps in this direction. As a part of the first major
revision of the ICD in three decades, the new diagnostic classification for mental disorders and
the CDDR were developed based on comprehensive reviews of available scientific evidence and
best clinical practices, using a participative global, multidisciplinary and multilingual process.
Clinical utility and global applicability were guiding principles of this work, which was closely
linked to a systematic programme of field studies involving thousands of clinicians around
the globe.
The overall ICD-11 represents an enormous step forward, being based on and designed to be
fully integratable with electronic health information infrastructure, which dramatically expands
the capacities and flexibility of the classification system. It is likely to be the standard for global
health information for some time – perhaps as long or longer than was ICD-10. A key aspect
of WHO’s plans regarding ICD-11 is that regular updates will occur every 2 years; these will
provide an opportunity to modify the classification to reflect new knowledge and changing
circumstances. It is anticipated that a greater number of changes will be made early on, as
Member States gain experience in actually using the classification. This will provide an important
mechanism for making refinements or clarifications to the classification of mental, behavioural
and neurodevelopmental disorders should they be justified based on emerging evidence and
clinical experience.
Introduction

07 - References
References
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
References2
1.
World Health Assembly Update, 25 May 2019.
Geneva: World Health Organization; 2019
(https://www.who.int/news/item/25-05-2019world-health-assembly-update).
2.
ICD-11 Reference Guide. Geneva: World Health
Organization; 2019 (https://icdcdn.who.int/
icd11referenceguide/en/html/index.html).
3.
Basic documents, 49th edition. Geneva: World
Health Organization; 2020 (https://apps.who.
int/iris/handle/10665/339554).
4.
International Statistical Classification of
Diseases and Related Health Problems (ICD).
Geneva: World Health Organization; 2022
(https://www.who.int/standards/classifications/
classification-of-diseases).
5.
International Advisory Group for the Revision
of ICD-10 Mental and Behavioural Disorders.
A conceptual framework for the revision of the
ICD-10 classification of mental and behavioural
disorders. World Psychiatry. 2011;10:86–92.
doi:10.1002/j.2051-5545.2011.tb00022.x.
6.
Reed GM, First MB, Kogan CS, Hyman SE,
Gureje O, Gaebel W et al. Innovations and
changes in the ICD-11 classification of mental,
behavioural and neurodevelopmental disorders.
World Psychiatry. 2019;18:3–19. doi:10.1002/
wps.20611.
7.
Rehm J, Shield KD. Global burden of disease
and the impact of mental and addictive
disorders. Curr Psychiatry Rep. 2019;21(2):10.
doi:10.1007/s11920-019-0997-0.
8.
ICD-11 for Mortality and Morbidity Statistics
(ICD-11 MMS) [website]. Geneva: World
Health Organization; 2023 (https://ICD.who.
int/browse11/l-m/en#/).
9.
International statistical classification of diseases,
injuries and causes of death, sixth revision.
Geneva: World Health Organization; 1949.
10. Manual of the international statistical
classification of diseases, injuries, and causes
of death. Geneva: World Health Organization;
1957.
11. International statistical classification of diseases,
injuries, and causes of death, eighth revision.
Geneva: World Health Organization; 1967.
12. Glossary of mental disorders and guide to
their classification. Geneva: World Health
Organization; 1974.
13. International statistical classification of diseases,
injuries, and causes of death, ninth revision.
Geneva: World Health Organization; 1979.
2 All references accessed 22–28 February 2023.
14. International statistical classification of diseases
and related health problems, 10th revision.
Geneva: World Health Organization; 1992.
15. The ICD-10 classification of mental and
behavioural disorders: clinical descriptions and
diagnostic guidelines. Geneva: World Health
Organization; 1992.
16. First MB, Reed GM, Hyman SE, Saxena S. The
development of the ICD-11 clinical descriptions
and diagnostic guidelines for mental and
behavioural disorders. World Psychiatry.
2015;14(1):82–90. doi:10.1002/wps.20189.
17. Keeley JW, Reed GM, Roberts MC, Evans SC,
Medina-Mora ME, Robles R et al. Developing
a science of clinical utility in diagnostic
classification systems field study strategies
for ICD-11 mental and behavioral disorders.
Am Psychol. 2016;71(1):3–16. doi:10.1037/
a0039972.
18. Reed GM, Sharan P, Rebello TJ, Keeley JW,
Medina-Mora ME, Gureje O et al. The ICD11 developmental field study of reliability of
diagnoses of high-burden mental disorders:
results among adult patients in mental health
settings of 13 countries. World Psychiatry.
2018;17(2):174–86. doi:10.1002/wps.20524.
19. Reed GM, Keeley JW, Rebello TJ, First MB,
Gureje O, Ayuso-Mateos JL et al. Clinical
utility of ICD-11 diagnostic guidelines for
high-burden mental disorders: results from
mental health settings in 13 countries. World
Psychiatry. 2018;17(3):306–15. doi:10.1002/
wps.20581.
20. Gaebel W. Status of psychotic disorders in
ICD-11. Schizophr Bull. 2012;38(5):895–8.
doi:10.1093/schbul/sbs104.
21. Maj M, Reed GM, editors. The ICD-11
classification of mood and anxiety disorders:
Background and options. World Psychiatry.
2012;11(Suppl. 1).
22. Stein DJ, Kogan CS, Atmaca M, Fineberg NA,
Fontenelle LF, Grant JE et al. The classification
of obsessive-compulsive and related disorders in
the ICD-11. J Affect Disord. 2016;190:663–74.
doi:10.1016/j.jad.2015.10.061.
23. Kogan CS, Stein DJ, Maj M, First MB,
Emmelkamp PM, Reed GM. The classification
of anxiety and fear-related disorders in the
ICD-11. Depress Anxiety. 2016;33(12):1141–54.
doi:10.1002/da.22530.
24. Maercker A, Brewin CR, Bryant RA, Cloitre M,
van Ommeren M, Jones LM et al. Diagnosis and
classification of disorders specifically associated
with stress: proposals for ICD-11. World
Psychiatry. 2013;12(3):198–206. doi:10.1002/
wps.20057.
Poznyak V, Reed GM, Medina-Mora ME.
Aligning the ICD-11 classification of disorders
due to substance use with global service needs.
Epidemiol Psychiatr Sci 2018;27(3):212–18.
doi:10.1017/S2045796017000622.
Krueger RB, Reed GM, First MB, Marais A,
Kismodi E, Briken P. Proposals for paraphilic
disorders in the International Classification
of Diseases and Related Health Problems,
Eleventh Revision (ICD-11). Arch Sex Behav.
2017;46(5):1529–45. doi:10.1007/s10508-0170944-2.
Fuss J, Lemay K, Stein DJ, Briken P, Jakob R,
Reed GM et al. Public stakeholders’ comments
on ICD-11 chapters related to mental and sexual
health. World Psychiatry. 2019;18(2):233–5.
doi:10.1002/wps.20635.
Guler J, Roberts MC, Medina-Mora ME, Robles
R, Gureje O, Keeley JW et al. Global collaborative
team performance for the revision of the
International Classification of Diseases: a case
study of the World Health Organization Field
Studies Coordination Group. Int J Clin Health
Psychol. 2018;18(3):189–200. doi:10.1016/j.
ijchp.2018.07.001.
Reed GM, Mendonça Correia J, Esparza P, Saxena
S, Maj M. The WPA-WHO Global Survey of
Psychiatrists’ Attitudes Towards Mental Disorders
Classification. World Psychiatry. 2011;10(2):118–
doi:10.1002/j.2051-5545.2011.tb00034.x.
Evans SC, Reed GM, Roberts MC, Esparza
P, Watts AD, Correia JM et al. Psychologists’
perspectives on the diagnostic classification of
mental disorders: results from the WHO-IUPsyS
Global Survey. Int J Psychol. 2013;48(3):177–93.
doi:10.1080/00207594.2013.804189.
Robles R, Fresán A, Evans SC, Medina-Mora
ME, Maj M, Reed GM. Problematic, absent
and stigmatizing diagnoses in current mental
disorders classifications: results from the WHOWPA and WHO-IUPsyS Global Surveys. Int
J Clin Health Psychol. 2014;14(3):165–77.
doi:10.1016/j.ijchp.2014.03.003.
Robles R, Fresán A, Medina-Mora ME, Sharan P,
Roberts MC, Mari JJ et al. Categories that should
be removed from mental disorders classifications:
perspectives and rationales of clinicians from
eight countries. J Clin Psychol. 2015;71(3):267–
doi:10.1002/jclp.22145.
Roberts MC, Reed GM, Medina-Mora ME,
Keeley JW, Sharan P, Johnson DK et al. A
global clinicians’ map of mental disorders to
improve ICD-11: analysing meta-structure
to enhance clinical utility. Int Rev Psychiatry.
2012;24(6):578–90. doi:10.3109/09540261.201
2.736368.
Reed GM, Roberts MC, Keeley J, Hooppell C,
Matsumoto C, Sharan P et al. Mental health
professionals’ natural taxonomies of mental
disorders: implications for the clinical utility
of the ICD-11 and the DSM-5. J Clin Psychol.
2013;69(12):1191–212. doi:10.1002/jclp.22031.
Introduction
Evans SC, Roberts MC, Keeley JW, Blossom
JB, Amaro CM, Garcia AM et al. Vignette
methodologies for studying clinicians’ decisionmaking: validity, utility, and application
in ICD-11 field studies. Int J Clin Health
Psychol. 2015;15(2):160–70. doi:10.1016/j.
ijchp.2014.12.001.
Keeley JW, Gaebel W, First MB, Peterson DL,
Rebello T, Sharan P et al. Psychotic disorder
symptom rating scales: are dichotomous or
multi-point scales more clinically useful? – An
ICD-11 field study. Schizophr Res. 2018;202:254–
doi:10.1016/j.schres.2018.07.006.
First MB, Rebello TJ, Keeley JW, Bhargava
R, Dai Y, Kulygina M et al. Do mental health
professionals use diagnostic classifications the
way we think they do? A global survey. World
Psychiatry. 2018;17(2):187–95. doi:10.1002/
wps.20525.
Keeley JW, Briken P, Evans SC, First MB,
Klein V, Krueger RB et al. Can clinicians use
dimensional information to make a categorical
diagnosis of paraphilic disorders? An ICD-11
field study. J Sex Med. 2021;18(9):1592–606.
doi:10.1016/j.jsxm.2021.06.016.
Keeley JW, Reed GM, Roberts MC, Evans
SC, Robles R, Matsumoto C et al. Disorders
specifically associated with stress: a
case-controlled field study for ICD-11
mental and behavioural disorders. Int J
Clin Health Psychol. 2016;16(2):109–27.
doi:10.1016/j.ijchp.2015.09.002.
Claudino AM, Pike KM, Hay P, Keeley JW,
Evans SC, Rebello TJ et al. The classification
of feeding and eating disorders in the
ICD-11: results of a field study comparing
proposed ICD-11 guidelines with existing
ICD-10 guidelines. BMC Med. 2019;17(1):93.
doi:10.1186/s12916-019-1327-4.
Peterson DL, Webb CA, Keeley JW, Gaebel W,
Zielasek J, Rebello TJ et al. The reliability and
clinical utility of ICD-11 schizoaffective disorder:
a field trial. Schizophr Res. 2019;208:235–41.
doi:10.1016/j.schres.2019.02.011.
Rebello TJ, Keeley JW, Kogan CS, Sharan
P, Matsumoto C, Kuligyna M et al. Anxiety
and fear-related disorders in the ICD-11:
results from a global case-controlled field
study. Arch Med Res. 2019;50(8):490–501.
doi:10.1016/j.arcmed.2019.12.012.
Kogan CS, Stein DJ, Rebello TJ, Keeley JW, Chan
KJ, Fineberg NA et al. Accuracy of diagnostic
judgements using ICD-11 vs. ICD-10 diagnostic
guidelines for obsessive-compulsive and related
disorders. J Affect Disord. 2020;273:328–40.
doi:10.1016/j.jad.2020.03.103.
Kogan CS, Maj M, Rebello TJ, Keeley JW,
Kulygina M, Matsumoto C et al. A global field
study of the International Classification of
Diseases (ICD-11) mood disorders clinical
descriptions and diagnostic guidelines.
J Affect Disord. 2021;295:1138–50.
doi:10.1016/j.jad.2021.08.050.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
45. Evans SC, Roberts MC, Keeley JW, Rebello
TJ, de la Peña F, Lochman JE et al. Diagnostic
classification of irritability and oppositionality
in youth: a global field study comparing ICD11 with ICD-10 and DSM-5. J Child Psychol
Psychiatry. 2021;62(3):303–12. doi:10.1111/
jcpp.13244.
46. Gaebel W, Stricker J, Riesbeck M, Zielasek J,
Kerst A, Meisenzahl-Lechner E et al. Accuracy
of diagnostic classification and clinical utility
assessment of ICD-11 compared to ICD-10 in
10 mental disorders: findings from a web-based
field study. Eur Arch Psychiatry Clin Neurosci.
2020;270(3):281–9. doi:10.1007/s00406-01901076-z.
47. Gaebel W, Riesbeck M, Zielasek J, Kerst
A, Meisenzahl-Lechner E, Köllner V et
al. Internetbasierte Untersuchungen zur
diagnostischen Klassifikation und Kodierung
psychischer Störungen im Vergleich von
ICD-11 und ICD-10 [Web-based field studies
on diagnostic classification and code assignment
of mental disorders: comparison of ICD11 and ICD-10]. Fortschr Neurol Psychiatr.
2018;86(3):163–71. doi:10.1055/s-0044-100508
(in German).
48. Robles R, de la Peña FR, Medina-Mora ME,
Marquéz-Caraveo MED, Domínguez T, Juárez
F et al. ICD-11 guidelines for mental and
behavioral disorders of children and adolescents:
Reliability and clinical utility. Psychiatr
Serv. 2022;73(4):396-402. doi: 10.1176/appi.
ps.202000830.
49. Lemay KR, Kogan CS, Rebello TJ, Keeley JW,
Bhargava R, Sharan P et al. An international field
study of the ICD-11 behavioural indicators for
disorders of intellectual development. J Intellect
Disabil Res. 2022;66(4):376–91. doi:10.1111/
jir.12924.
50. Degenhardt L, Bharat C, Bruno R, Glantz
MD, Sampson NA, Lago L et al. Concordance
between the diagnostic guidelines for alcohol
and cannabis use disorders in the draft ICD-11
and other classification systems: analysis of data
from the WHO’s World Mental Health Surveys.
Addiction. 2019;114(3):534–52. doi:10.1111/
add.14482.
51. Diagnostic and Statistical Manual of Mental
Disorders, 4th edition. Washington DC:
American Psychiatric Association; 1994.
52. Diagnostic and statistical manual of mental
disorders, 5th edition. Arlington, VA: American
Psychiatric Association; 2013.
53. Hackmann C, Balhara YPS, Clayman K, Nemec
PB, Notley C, Pike K et al. Perspectives on
ICD-11 to understand and improve mental
health diagnosis using expertise by experience
(INCLUDE Study): an international qualitative
study. Lancet Psychiatry. 2019;6(9):778–85.
doi:10.1016/S2215-0366(19)30093-8.
54. Roelandt JL, Baleige A, Koenig M, Demassiet V,
Agoub M, Barikova V et al. How service users
and carers understand, perceive, rephrase, and
communicate about “depressive episode” and
“schizophrenia” diagnoses: an international
participatory research. Soc Psychiatry Psychiatr
Epidemiol. 2020;55(9):1201–13. doi:10.1007/
s00127-020-01836-6.
55. First MB, Gaebel W, Maj M, Stein DJ, Kogan CS,
Saunders JB et al. An organization- and categorylevel comparison of diagnostic requirements for
mental disorders in ICD-11 and DSM-5. World
Psychiatry. 2021;20(1):34–51. doi:10.1002/
wps.20825.
56. Reed GM, First MB, Billieux J, Cloitre M, Briken
P, Achab S et al. Emerging experience with
selected new categories in the ICD-11: complex
PTSD, prolonged grief disorder, gaming disorder,
and compulsive sexual behaviour disorder. World
Psychiatry. 2022;21(2):189–213. doi:10.1002/
wps.20960.
57. Reed GM, Drescher J, Krueger RB, Atalla E,
Cochran SD, First MB et al. Disorders related
to sexuality and gender identity in the ICD-11:
revising the ICD-10 classification based on
current scientific evidence, best clinical practices,
and human rights considerations. World
Psychiatry. 2016;15(3):205–21. doi:10.1002/
wps.20354.
58. Robles R, Fresán A, Vega-Ramírez H, Cruz-Islas
J, Rodríguez-Pérez V, Domínguez-Martínez T
et al. Removing transgender identity from the
classification of mental disorders: a Mexican
field study for ICD-11. Lancet Psychiatry.
2016;3(9):850–9.
doi:10.1016/S22150366(16)30165-1.
59. Robles R, Keeley JW, Vega-Ramírez H,
Cruz-Islas J, Rodríguez-Pérez V, Sharan P
et al. (2021). Validity of categories related to
gender identity in ICD-11 and DSM-5 among
transgender individuals who seek genderaffirming medical procedures. Int J Clin Health
Psychol. 2022;22(1):100281. doi:10.1016/
j.ijchp.2021.100281.
60. Gureje O, Lewis-Fernandez R, Hall BJ, Reed
GM. Systematic inclusion of culture-related
information in ICD-11. World Psychiatry.
2019;18(3):357–8. doi:10.1002/wps.20676.
61. Gureje O, Lewis-Fernandez R, Hall BJ, Reed GM.
Cultural considerations in the classification of
mental disorders: why and how in ICD-11. BMC
Med. 2020;18(1):25. doi:10.1186/s12916-0201493-4.
62. Reed GM, Rebello TJ, Pike KM, MedinaMora ME, Gureje O, Zhao M et al. WHO’s
Global Clinical Practice Network for mental
health. Lancet Psychiatry. 2015;2(5):379–80.
doi:10.1016/S2215-0366(15)00183-2.
The ICD-10 classification of mental and
behavioural disorders: diagnostic criteria
for research. Geneva: World Health
Organization; 1993 (https://apps.who.int/iris/
handle/10665/37108).
First MB. Harmonisation of ICD-11 and DSM-V:
opportunities and challenges. Br J Psychiatry.
2009;195(5):382–90.
doi:10.1192/bjp.
bp.108.060822.
Wing JK, Babor T, Brugha T, Burke J, Cooper
JE, Giel R et al. SCAN. Schedules for Clinical
Assessment in Neuropsychiatry. Arch Gen
Psychiatry. 1990;47(6):589–93. doi:10.1001/
archpsyc.1990.01810180089012.
Rijnders CA, van den Berg JF, Hodiamont
PP, Nienhuis FJ, Furer JW, Mulder J et al.
Psychometric properties of the Schedules
for Clinical Assessment in Neuropsychiatry
(SCAN-2.1). Soc Psychiatry Psychiatr Epidemiol.
2000;35(8):348–52. doi:10.1007/s001270050249.
Carragher N, Billieux J, Bowden-Jones H, Achab
S, Potenza MN, Rumpf HJ et al. Brief overview
of the WHO Collaborative Project on the
Development of New International Screening
and Diagnostic Instruments for Gaming
Disorder and Gambling Disorder. Addiction.
2021;117(7):2119–21. doi:10.1111/add.15780.
Clark LA, Corona-Espinosa A, Khoo S,
Kotelnikova Y, Levin-Aspenson HF, SerapioGarcía G et al. Preliminary scales for ICD-11
personality disorder: self and interpersonal
dysfunction plus five personality disorder
trait domains. Front Psychol. 2021;12:668724.
doi:10.3389/fpsyg.2021.668724.
Introduction
Oltmanns JR, Widiger TA. A self-report
measure for the ICD-11 dimensional trait model
proposal: the personality inventory for ICD-11.
Psychol Assess. 2018;30(2):154–69. doi:10.1037/
pas0000459.
Bach B, Brown TA, Mulder RT, Newton-Howes
G, Simonsen E, Sellbom M. Development and
initial evaluation of the ICD-11 personality
disorder severity scale: PDS-ICD-11. Personal
Ment Health. 2021;15(3):223–36. doi:10.1002/
pmh.1510.
Olajide K, Munjiza J, Moran P, O’Connell L,
Newton-Howes G, Bassett P et al. Development
and psychometric properties of the Standardized
Assessment of Severity of Personality Disorder
(SASPD). J Pers Disord. 2018;32(1):44–56.
doi:10.1521/pedi_2017_31_285.
Cloitre M, Shevlin M, Brewin CR, Bisson JI,
Roberts NP, Maercker A et al. The International
Trauma Questionnaire: development of a self‐
report measure of ICD‐11 PTSD and complex
PTSD. Acta Psychiatr Scand. 2018;138(6):536–
doi:10.1111/acps.12956.
Bőthe B, Potenza MN, Griffiths MD, Kraus
SW, Klein V, Fuss J et al. The development of
the Compulsive Sexual Behavior Disorder
Scale (CSBD-19): an ICD-11 based screening
measure across three languages. J Behav Addict.
2020;9(2):247–58. doi:10.1556/2006.2020.00034.
Bőthe B, Koós M, Nagy L, Kraus SW,
Potenza MN, Demetrovics Z. International
Sex Survey: study protocol of a large,
cross-cultural collaborative study in 45
countries. J Behav Addict. 2021;10(3):632–45.
doi:10.1556/2006.2021.00063.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

04 - Using the CDDR for ICD 11 mental, behavioural and

01 - Components of the CDDR
Components of the CDDR
21
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
Using the CDDR for ICD-11
mental, behavioural and
neurodevelopmental disorders
in clinical settings
This chapter provides a basic orientation to applying the CDDR for ICD-11 mental, behavioural
and neurodevelopmental disorders in clinical settings. As previously indicated, the CDDR are
not intended to function as a manual for conducting clinical assessments. Rather, they are to be
applied in the context of clinicians’ broader understanding of the disorders they are assessing
and the clinical competencies they have gained through appropriate education, training and
experience. This chapter also contains information on relevant aspects of diagnostic coding, some
of which are the result of important innovations in how ICD-11 categories are represented and
relate to one another. This material on coding relates to the entire ICD-11 and is not specific to
the chapter on mental, behavioural and neurodevelopmental disorders. Coding is discussed here
as it affects the implementation of the CDDR.
This chapter includes a discussion of the following issues:
• components of the CDDR;
• making an ICD-11 diagnosis using the CDDR;
• co-occurring and mutually exclusive diagnoses;
• other specified and unspecified categories;
• other ICD-11 chapters relevant to diagnostic formulation of mental, behavioural and
neurodevelopmental disorders; and
• ICD-11 diagnostic coding.
Components of the CDDR
A major improvement in the ICD-11 CDDR compared to the ICD-10 CDDG is the consistency
of structure and information across major categories. The information provided for the main
disorder categories in the CDDR is organized under the following headings:
• Essential (required) features
• Additional clinical features
• Boundary with normality (threshold)
• Course features
• Developmental presentations
• Culture-related features
• Sex- and/or gender-related features
• Boundaries with other disorders and conditions (differential diagnosis).
The information provided is based on reviews of the available evidence, and is intended to be
useful in making diagnostic judgements about individual patients. These sections do not provide
a summary of all available information about the topic in question, but rather focus on issues that
may be specifically relevant to assigning a diagnosis to an individual patient. If a particular heading
(e.g. developmental presentations, sex- and/or gender-related information) is not provided for a
specific disorder, this is because insufficient evidence was identified as a basis for making clinically
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
relevant and broadly applicable statements. The following sections give a brief description of the
information provided in each section of the CDDR for the main disorder categories.
Essential (required) features
This section provides guidance regarding the features needed to make the diagnosis confidently.
The essential features represent those symptoms or characteristics that a clinician could reasonably
expect to find in all cases of the disorder. In this sense, essential features resemble diagnostic
criteria. However, artificial precision in diagnostic requirements, such as using exact counts of
required symptoms and specific duration requirements as diagnostic cutoffs has generally been
avoided unless these have been well established with appropriate global evidence. This allows
for broader exercise of the professional’s clinical judgement, depending on the characteristics
of the patient – including cultural variations in presentation – and local circumstances. For
example, it makes little sense to impose a rigid duration requirement of 6 months for a patient
who has been experiencing the required symptoms for 5 months if the current visit represents
the only opportunity that the patient is likely to have for appropriate treatment for the next year.
This flexibility in language also allows the clinician to differentially weigh symptoms that are
particularly severe and impairing, and to consider culturally specific “idioms of distress” that may
differ somewhat in the way the patient understands and describes their experience but represent
the same underlying phenomenon (e.g. somatic expressions of psychological distress).
Additional clinical features
This section describes additional clinical features that are not diagnostically determinative but
are associated with the disorder frequently enough that they can help the clinician to recognize
variations in disorder presentation. This section is also used for alerting the clinician to the
likelihood that certain clinically important associated symptoms or co-occurring disorders may
be present and require assessment and treatment.
Boundary with normality (threshold)
This section provides guidance regarding the differentiation of the disorder from normal variation
in characteristics that may be continuous with, or similar to, the essential features of the disorder.
This section often specifies aspects of the disorder that are indicative of its pathological nature and
describes typical false-positives (i.e. clinical presentations that are similar in certain respects but
are considered to be non-pathological). For many disorders, the differentiation from normality is
based on the presence of significant distress or significant impairment in personal, family, social,
educational, occupational or other important areas of functioning.
Course features
This section provides clinically relevant information regarding the typical course of the disorder,
which is defined broadly to include information about age of onset, whether the disorder is
persistent or episodic, its likely progression or remission over time, and its temporal relationship
to life stressors and other disorders.
Developmental presentations
This section describes how symptom presentations may differ according to the individual’s
developmental stage. Many disorders traditionally thought of as disorders of adulthood (e.g.
depressive disorders) can present during childhood, and many disorders often thought of as
disorders of childhood persist into adulthood, with alterations in their presentation. For example,
presentations of attention deficit hyperactivity disorder in younger children often include
excessive motor activity. In adolescents and adults with attention deficit hyperactivity disorder, the

02 - Making an ICD 11 diagnosis using the CDDR
Making an ICD-11 diagnosis using the CDDR
23
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
equivalent phenomenon is experiencing feelings of physical restlessness or a sense of discomfort
with being quiet or sitting still. Also included in this section are developmental variations that are
more common in older adults, among whom many mental disorders are often underdiagnosed.
This section also contains information about different patterns of co-occurring conditions and
risks for associated sequelae according to developmental stage.
Culture-related features
This section provides information regarding cultural considerations that should be considered
when making the diagnosis. This includes cultural variations in prevalence and symptoms of
disorders, sociocultural mechanisms that may account for this variation, and descriptions of
cultural concepts of distress that are relevant to diagnosis and treatment decisions. See the section
on cultural factors in the Introduction for additional information.
Sex- and/or gender-related features
This section covers sex- and/or gender-related diagnostic issues, including sex- and/or genderlinked differences in symptom presentation, community prevalence and presentation in
clinical settings.
Boundaries with other disorders and conditions (differential diagnosis)
This section lists other disorders that should be considered in the differential diagnosis –
particularly those that share presenting symptoms or features. For each of these disorders, this
section describes the features that differentiate it from the index disorder, providing guidance to
the clinician about how to make this differentiation. Issues related to the concurrent diagnosis
of the disorder being distinguished from the index disorder are also discussed in this section.
The boundary descriptions generally cover all information conveyed by exclusion terms on the
ICD-11 MMS platform.3 Exclusion terms are often confusing to clinicians because they assume
that they mean that the excluded condition cannot be diagnosed simultaneously with the index
condition, which is not the case. Rather, an exclusion term in the ICD-11 MMS indicates that the
condition excluded is not part of the condition described by the category, so that both conditions
may be used at the same time if warranted. These considerations are covered more clearly and
explicitly in the boundary descriptions found in this section of the CDDR.
Making an ICD-11 diagnosis using the CDDR
Consideration of essential (required) features
The diagnostic process starts with a consideration of whether the presentation meets the
diagnostic requirements laid out in the essential (required) features section of the CDDR for
the diagnosis under consideration. There are two types of essential features: those that must
be present for the diagnostic requirements to be met and those that require a consideration of
whether the symptoms may be better explained by other mental disorders that share presenting
features. This aspect of the diagnostic evaluation includes a consideration of:
• particular symptoms that must be present (which may be expressed as a minimum number
of symptoms from an item list – e.g. “Several of the following symptoms must be present”);
• the minimum amount of time that symptoms need to have been present (e.g. “present…for
a period of at least several months”);
• frequency or proportion of the time that symptoms need to be present during that required
period of time (e.g. “most of the time”, “most of the day, nearly every day”, “for more days
than not”, “more than 1 hour per day”, “multiple incidents”);
3 ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS) [website]. Geneva: World Health Organization; 2023 (https://ICD.who.
int/browse11/l-m/en#/).
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• in some cases, whether the onset of symptoms meets a particular diagnostic requirement (e.g.
“characterized by the rapid and concurrent onset of several characteristic symptoms”); and
• whether the symptoms meet any stated requirement regarding their impact on the individual’s
functioning (“symptoms result in significant impairment in personal, family, social,
educational, occupational or other important areas of functioning”) or have resulted in
“significant distress”.
As noted, the CDDR generally avoid artificial precision in quantifying the exact number of items
that must be present from a list of symptoms or specifying a precise duration requirement. Too
rigidly applied, these can create barriers – for example, due to cultural variation or in contexts
where an individual may have limited opportunities to access care. The essential features attempt
to describe the relevant clinical phenomena clearly in order to allow for flexible application of
the CDDR in establishing the presence of each diagnostic item. It is up to the diagnosing health
professional to make a judgement about its presence or absence, considering the entire context
of the clinical presentation. If the essential features do not mention a required duration for the
symptoms, it is assumed that the symptoms should have been present for at least one month in
order to assign the diagnosis.
Consideration of other disorders that may share presenting features
This aspect of the diagnostic evaluation includes whether the symptoms are best considered
to be a manifestation of a disease or disorder classified outside of the mental, behavioural and
neurodevelopmental disorders chapter (e.g. a sleep-wake disorder, a disease of the nervous
system, or another medical condition). In cases where the symptoms are judged to be a
direct pathophysiological consequence of a medical condition and the mental, behavioural or
neurodevelopmental symptoms are a specific focus of clinical attention, a diagnosis of one of
the secondary mental or behavioural syndromes associated with disorders and diseases classified
elsewhere may be assigned, in addition to the appropriate diagnosis for the etiological medical
condition. For example, depressive symptoms similar to those of a depressive episode that are
judged to be due to hypothyroidism would warrant a diagnosis of secondary mood syndrome, with
depressive symptoms in addition to hypothyroidism. However, certain disorders are diagnosed
regardless of whether they are believed to be caused by a medical condition classified elsewhere,
including neurocognitive disorders and certain neurodevelopmental disorders (i.e. disorders of
intellectual development, autism spectrum disorder, stereotyped movement disorder).
The evaluation also includes whether the symptoms are due to the effects of a substance or
medication on the central nervous system. If so, a diagnosis of one of the substance-induced
mental disorders (e.g. alcohol-induced delirium, amfetamine-induced psychotic disorder) is
likely to be appropriate. Other categories specifically linked to substances or medications include
catatonia induced by substances or medications; amnestic disorder due to psychoactive substances,
including medications; and dementia due to psychoactive substances, including medications.
Finally, the diagnostic evaluation includes whether there are other ICD-11 mental, behavioural
and neurodevelopmental disorders that share features with the disorder under consideration,
that might better account for the symptomatic presentation. Whether a particular disorder that
could account for the symptoms in fact better accounts for them is a clinical judgement. For
example, the essential features of social anxiety disorder, which are characterized by marked and
excessive fear or anxiety that occurs in social situations, includes the diagnostic requirement
that “the symptoms are not better accounted for by another mental disorder (e.g. agoraphobia,
body dysmorphic disorder, olfactory reference disorder)”. Each of these listed disorders may
also involve the development of anxiety in social situations. For body dysmorphic disorder and
olfactory reference disorder, the anxiety involves excessive self-consciousness about perceived
defects in appearance or emitting an offensive body odour, respectively. In agoraphobia, the
25
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
anxiety is related to a fear of specific negative outcomes in social situations, such as panic attacks
or other incapacitating (e.g. falling) or embarrassing (e.g. incontinence) physical symptoms. In
making the clinical judgement of whether the symptoms of anxiety in social situations are better
accounted for by one of these other disorders, the clinician takes into account factors such as the
temporal sequence of the symptoms, which symptoms predominate, and the presence of other
clinical features.
Consideration of boundary with normality (threshold)
For the most part, mental disorders occur on a severity continuum with no sharp division
separating cases and non-cases (i.e. normality), making the differentiation between a mild case
of the disorder and non-disordered normal variation potentially challenging. It is advisable to
review this section because, in some cases, what might appear to be evidence of psychopathology
may in fact be within the bounds of normality given the individual’s developmental stage and
cultural context. This section of the CDDR also points out common false-positive presentations.
Consideration of boundaries with other disorders and conditions
(differential diagnosis)
This section of the CDDR is an extension and expansion of the “consideration of other
disorders that may share presenting features” element of the essential features and provides
a more comprehensive review of other disorders that should be considered in the differential
diagnosis. The clinician should consider whether any of the disorders listed might explain the
presenting symptoms.
Consideration of co-occurring and mutually exclusive diagnoses
ICD-11 diagnoses are generally assigned for every disorder for which the diagnostic requirements
are met; that is, co-occurring diagnoses are typically permitted. However, there are specific
situations in which the diagnostic requirements may be met for more than one disorder, typically
because of symptom overlap, but the CDDR recommend making only a single diagnosis. In most
cases, this is noted in the essential features but, in some cases, it is noted in the description of
the differential diagnosis for that disorder in the section on boundaries with other disorders
and conditions.
In the CDDR, recommendations against diagnosing two particular disorders together (i.e. cooccurrence) are generally made in one of the following ways.
• “The symptoms do not meet the diagnostic requirements for …”; “The symptoms do not
occur exclusively during episodes of …”; “The individual has never met the diagnostic
requirements for …”: these types of exclusionary statements are typically used if the
symptomatic presentation of the disorder in question is already part of the definition of
another disorder, and an additional diagnosis of the excluded disorder would be redundant.
• The first case (“symptoms do not meet diagnostic requirement for”) prevents the assignment
of both diagnoses if the diagnostic requirements for both disorders are met at the same time,
and generally indicates that the other disorder should be diagnosed instead. For example,
the CDDR for bulimia nervosa indicate that the diagnosis should only be assigned if the
symptoms do not meet the diagnostic requirements for anorexia nervosa, so that individuals
who maintain an excessively low body weight by reducing their energy intake through purging
behaviour would be assigned only a single diagnosis of anorexia nervosa rather than diagnoses
of both anorexia nervosa and bulimia nervosa. The presence of bulimia-like behaviour is
indicated with the binge-purge pattern specifier applied to the diagnosis of anorexia nervosa.

03 - Other specified and unspecified categories
Other specified and unspecified categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The second case (“symptoms do not occur exclusively during episodes of”) similarly prevents
diagnosing the disorder in question if its symptoms only occur during episodes of another
disorder. For example, the CDDR for dissociative amnesia indicate that it should not be
diagnosed if the dissociative memory loss occurs only during episodes of trance disorder;
the amnestic symptoms are features of trance disorder rather than a separate condition.
• The third case (“individual has never met the diagnostic requirements for”) prevents
a diagnosis from being made if there is currently, or a history of, another disorder. For
example, the CDDR for schizotypal disorder indicate that, in order to assign the diagnosis,
the individual’s past symptoms should never have met the diagnostic requirements
for schizophrenia, schizoaffective disorder or delusional disorder. Similarly, recurrent
depressive disorder is not diagnosed if the individual has ever experienced a manic, mixed
or hypomanic episode.
• “The symptoms are better accounted for by another mental disorder”: many essential
features sections include the requirement that the symptomatic presentation is not better
accounted for by another mental disorder. This is typically the case when the symptomatic
requirements of one disorder are also a possible manifestation of another disorder. An
example is the occurrence of significant anxiety symptoms that develop in anticipation of
attending school. If the anxiety is entirely accounted for by fear of speaking in class and/or
social interaction with peers, a diagnosis of social anxiety disorder would be most appropriate.
On the other hand, if the anxiety is entirely accounted for by fear of being separated from
attachment figures while at school, a diagnosis of separation anxiety disorder would be
appropriate. However, if the anxiety is related to both fear of negative evaluation by peers
and separation from attachment figures, and all other diagnostic requirements for both
disorders are met, then both diagnoses may be assigned. These distinctions typically require
clinical judgement, in this example, about the relevant “focus of apprehension” or stimuli or
situations that trigger the anxiety.
• Symptomatic presentations accounted for by another disorder can sometimes be assigned
an additional diagnosis if the second diagnosis is a separate focus of clinical attention.
Such recommendations may be noted in the section on boundaries with other disorders
and conditions section. For example, stereotyped movements may be part of presentation
of autism spectrum disorder: “repetitive and stereotyped motor movements, such as wholebody movements…” are listed as examples of “persistent restricted, repetitive and inflexible
patterns of behaviour, interests or activities” in the essential features of autism spectrum
disorder. In the boundary with stereotyped movement disorder in the CDDR for autism
spectrum disorder, however, it is noted that “although such stereotyped movements are
typical in autism spectrum disorder, if they are severe enough to require additional clinical
attention – for example, because of self-injury – a co-occurring diagnosis of stereotyped
movement disorder may be warranted”.
• Finally, the boundaries with other disorders and conditions section may contain other
recommendations regarding whether or not to diagnose more than one disorder. For
example, in the CDDR for generalized anxiety disorder, the boundary with depressive
disorders states that “generalized anxiety disorder may co-occur with depressive disorders,
but should only be diagnosed if the diagnostic requirements for generalized anxiety disorder
were met prior to the onset of or following complete remission of a depressive episode”.
Other specified and unspecified categories
By default, all groupings in ICD-11 contain what are called “residual categories”, which include
“other specified” categories with ICD-11 codes ending in “Y” (e.g. 6C7Y  Other specified
impulse control disorders) and “unspecified” categories with ICD-11 codes ending in “Z” (e.g.
6A8Z  Mood disorder, unspecified). Occasionally, residual categories are “suppressed”, or not
listed, in the ICD-11 MMS because the other categories contained in the grouping are considered

04 - Other ICD 11 chapters relevant to diagnostic
Other ICD-11 chapters relevant to diagnostic formulation of mental, behavioural and neurodevelopment
27
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
to be exhaustive. For example, the grouping elimination disorders contains enuresis, encopresis
and elimination disorder, unspecified; the other specified residual has been suppressed for this
grouping and thus does not appear in the MMS.
The CDDR include essential (required) features for other specified categories at the grouping
level (e.g. other specified mood disorder, other specified dissociative disorder). A particular other
specified diagnosis should be applied when the presentation is judged to be a clinically significant
mental disorder falling within a particular grouping of disorders (e.g. mood disorders, dissociative
disorders) because it shares primary clinical features with these disorders but does not fulfil the
diagnostic requirements of any of the other available categories. For example, a presentation that
included all of the essential features of schizophrenia but had not met the 1-month duration
requirement would appropriately be diagnosed as other specified primary psychotic disorder.
A presentation characterized by abnormal eating or feeding behaviours that did not correspond to
the essential features of any of the specific feeding and eating disorders categories but resulted in
significant risk or damage to health, significant distress or significant impairment in functioning
could be diagnosed as other specified feeding and eating disorder. Sometimes, other specified
diagnoses may refer to recognizable syndromes that have not been included as separate categories
in ICD-11 – for example, because they are very rare or are not sufficiently widely recognized
as disorders. Ganser syndrome, for example, would be diagnosed as other specified dissociative
disorder, and what is sometimes called “pathological demand avoidance” could be diagnosed
as other specified disruptive behaviour or dissocial disorder if it did not meet the diagnostic
requirements for oppositional defiant disorder. The characteristics of the presentation in other
specified disorder should be specified in the clinical record.
Unspecified categories are most commonly used by professional coders when the clinician has
provided insufficient information in the clinical record to assign a more specific diagnosis.
In clinical situations, unspecified categories are appropriate only when insufficient information
is available to make a more definitive diagnosis and, if possible, should be changed when
additional information becomes available. In contrast to other specified categories, which are
used when the clinician knows what the disorder is but there is no precisely corresponding code,
unspecified categories are used when the clinician has been unable to arrive at a precise diagnostic
determination. For example, an individual presenting in a hospital emergency department who
is exhibiting hallucinations and delusions in the absence of evidence of substance use, delirium
or dementia might be assigned a diagnosis of schizophrenia or other primary psychotic disorder,
unspecified, until a more complete assessment can be conducted. Unspecified categories should
not be used as an administrative shortcut when a more specific diagnosis can be assigned; this
results in a major loss of clinical and statistical information.
Other ICD-11 chapters relevant to diagnostic formulation
of mental, behavioural and neurodevelopmental disorders
Categories from any of the other 24 chapters in ICD-11 may be comorbid with a mental,
behavioural or neurodevelopmental disorder, and thus relevant to their diagnostic formulation.
However, the following chapters warrant particular attention:
Chapter 7. Sleep-wake disorders
The ICD-11 chapter on sleep-wake disorders brings together ICD-10 nonorganic sleep disorders
(F51) with “organic” sleep disorders (G47) that were classified in the ICD-10 chapter on diseases
of the nervous system, as well as categories previously included in several other chapters
(i.e. endocrine, nutritional and metabolic diseases; diseases of the respiratory system; certain
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
conditions originating in the perinatal period). Sleep-wake disorders previously included in the
ICD-10 chapter on mental and behavioural disorders include nightmare disorder, sleepwalking
disorder, sleep terrors and “nonorganic” versions of insomnia disorders, hypersomnia disorders
and circadian rhythm sleep-wake disorders (disorders of the sleep-wake schedule in ICD-10).
The unified ICD-11 chapter on sleep-wake disorders reflects the fact that the pathophysiology
of most of these disorders is complex and includes both physiological and psychological/
behavioural components. ICD-11 abandons outdated and incorrect assumptions about the
etiology of sleep-wake disorders – in particular, the obsolete distinction between “organic” and
“nonorganic” disorders. The chapter is intended to enhance patient care and public health by
creating a more visible and accurate system that will enhance clinician awareness and improve
diagnostic accuracy and treatment. Placement of these conditions in a separate chapter on sleepwake disorders is in no way intended to indicate that they should not be diagnosed and treated by
appropriately trained mental health professionals.
Chapter 8. Diseases of the nervous system
Diseases of the nervous system have a close relationship with mental, behavioural and
neurodevelopmental disorders. Disorders in both chapters may affect cognition, emotional
regulation or behaviour, and reflect dysfunctions in the psychological, biological or developmental
processes. Given that mental, behavioural and neurodevelopmental disorders also affect the brain,
in some instances the distinction between the two chapters is arbitrary and reflects professional
tradition – especially the boundary between psychiatry and neurology – as much as biological or
phenomenological differences between the conditions listed in each.
For some conditions, the psychological, behavioural or developmental syndrome is classified
in the mental, behavioural and neurodevelopmental disorders chapter, while the underlying
etiology may be classified in diseases of the nervous system. This includes disorders of
intellectual development, autism spectrum disorder and stereotyped movement disorder in the
neurodevelopmental disorders grouping; and delirium, mild neurocognitive disorder, amnestic
disorder and dementia in the neurocognitive disorders grouping, all of which are diagnosed
regardless of etiology. If the etiology is known, the corresponding diagnosis should also be assigned,
which is often but not always in in the chapter on diseases of the nervous system. The other
neurodevelopmental disorders (e.g. developmental learning disorder, developmental speech or
language disorder, developmental motor coordination disorder) are generally not diagnosed if the
symptoms are fully accounted for by a disease of the nervous system. When mental, behavioural
or neurodevelopmental syndromes are judged to be a direct pathological consequence of a
disease of the nervous system and are a specific focus of clinical attention, a diagnosis from the
grouping secondary mental or behavioural syndromes associated with disorders and diseases
classified elsewhere may be assigned. For example, a psychotic syndrome with prominent visual
hallucinations that is judged to be the direct pathophysiological consequence of Parkinson disease
would be diagnosed as secondary psychotic syndrome, with hallucinations along with a diagnosis
of Parkinson disease.
Tic disorders and acquired aphasia with epilepsy (Landau-Kleffner syndrome) were classified in
ICD-10 as emotional disorders with onset usually occurring in childhood and adolescence, but in
ICD-11 have been moved to the chapter on diseases of the nervous system. In addition, movement
disorders caused by medications (e.g. drug-induced parkinsonism, drug-induced dystonia),
which are associated with certain medications commonly used to treat mental disorders, are
included among the diseases of the nervous system.
29
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
Chapter 16. Diseases of the genitourinary system
This chapter includes a grouping of premenstrual disturbances that may include significant mood
symptoms, such as depressed mood and irritability, as well as somatic and cognitive symptoms
that may also occur in mood disorders. In particular, premenstrual dysphoric disorder is
secondary-parented in the mood disorders grouping of ICD-11, and the CDDR for this entity are
provided in this volume. In addition, while nearly all sexual dysfunctions classified as diseases of
the genitourinary system in ICD-10 have been moved to the new ICD-11 chapter on conditions
related to sexual health (see the next section), pain syndromes that are more generally associated
with genital organs or the menstrual cycle are classified in Chapter 16.
Chapter 17. Conditions related to sexual health
Analogously to sleep-wake disorders, the ICD-10 classification of sexual dysfunctions was based
on a Cartesian separation of “organic” and “nonorganic” conditions. Sexual dysfunctions not
caused by organic disorder or disease (F52), which also include “nonorganic” versions of the
sexual pain disorders vaginismus and dyspareunia, were classified in the ICD-10 chapter on
mental and behavioural disorders, and most “organic” sexual dysfunctions are classified in the
chapter on diseases of the genitourinary system. These have been brought together in a new
unified classification of sexual dysfunctions and sexual pain disorders in the ICD-11 chapter on
conditions related to sexual health. This approach is consistent with current, more integrative
clinical approaches in sexual health, and recognizes the large body of evidence that the origin
and maintenance of sexual dysfunctions and sexual pain disorders most often involves the
interaction of physiological and psychological/behavioural factors. Reformulated versions of all
sexual dysfunctions from the ICD-10 mental and behavioural disorders chapter can be found in
the ICD-11 chapter on conditions related to sexual health, except for ICD-10 excessive sexual
drive – a condition most closely related to compulsive sexual behaviour disorder in ICD-11 –
which is included in the grouping of impulse control disorders. As with sleep-wake disorders,
placement of these conditions in a separate chapter on conditions related to sexual health is
not intended to indicate that they should not be diagnosed and treated by appropriately trained
mental health professionals.
The ICD-11 chapter on conditions related to sexual health also includes gender incongruence,
which represents a reformulation and renaming of ICD-10 gender identity disorders. There
was substantial evidence that the nexus of stigmatization of transgender people and of mental
disorders had contributed to a doubly burdensome situation for transgender and gender-variant
people, and that stigma associated with the intersection of transgender status and mental disorders
had contributed to precarious legal status, human rights violations and barriers to appropriate
health care in this population. Although gender identity is clearly distinct from sex, this chapter
appeared to offer the most broadly acceptable home for categories related to gender identity,
while making it clear that they are no longer considered to be mental disorders. This position has
been supported by a series of ICD-11 field studies. Gender incongruence was not proposed for
elimination in ICD-11 because in many countries access to relevant health services is contingent
on a qualifying diagnosis.
Chapter 21. Symptoms, signs or clinical findings, not elsewhere classified
The categories in this chapter are not considered to be disorders but rather provide descriptions
of specific symptoms that may be used to describe the reason for a clinical encounter when a
more precise diagnosis has not been established for various reasons. These categories may also
be used to describe clinically important aspects of the individual’s presentation when a diagnosis
has been assigned.

05 - ICD 11 diagnostic coding
ICD-11 diagnostic coding
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
A part of this chapter is a detailed and comprehensive listing of mental or behavioural symptoms,
signs or clinical findings, which also includes definitions for each. These often represent
important problems in their own right (e.g. avolition, demoralization, apathy, thought blocking).
The categories from this section can be used to describe the clinical presentation in the absence
of a definitive mental, behavioural or neurodevelopmental disorder diagnosis. In addition, these
categories can be useful when a mental disorder diagnosis has been assigned, and the symptom
being described has implications for treatment but is not an essential feature of the disorder itself
and does not meet the diagnostic requirements for a co-occurring disorder. A listing of mental or
behavioural symptoms, signs or clinical findings included in this chapter, with their definitions,
is provided as part of the CDDR (p. 677).
Chapter 24. Factors influencing health status or contact with health
services
Categories from this chapter may be used when a person seeks mental health services for a reason
other than for symptoms of a mental disorder (e.g. counselling for a problem associated with
unemployment), or when the problem influences the person’s health status but is not in itself a
mental disorder. A number of categories in this chapter are relevant to mental health professionals
because they:
• represent a reason for a clinical encounter other than a mental disorder (e.g. counselling
related to sexuality, counselling related to procreative management);
• are a focus of intervention (e.g. relationship problems and maltreatment – see p. 707);
• are important to consider in the differential diagnosis of mental disorders (e.g. uncomplicated
bereavement, malingering); or
• are factors that may significantly contribute to the initiation or maintenance of disorders in
the mental, behavioural and neurodevelopmental disorders chapter, including recognized
social determinants of mental health (i.e. problems associated with finances, problems
associated with employment or unemployment, target of perceived adverse discrimination
or persecution).
A listing of factors influencing health status or contact with health services that are particularly
relevant to mental health and mental health services is provided as part of the CDDR (p. 733).
ICD-11 diagnostic coding
Among the most important innovations of ICD-11 is its ability to capture much more clinical
information associated with a particular diagnosis than was possible with ICD-10. Some of the
ICD-11 coding features discussed in this section are designed for optimal use in the context of
electronic information systems able to generate and interpret complex, multipart codes – for
example, based on checklists completed by the health professional. However, some of these
coding capabilities will also be useful to health professionals who are individually responsible
for determining and recording diagnoses and diagnostic codes. Even when coding itself is
done by professional coders, as in some countries and health systems, it is important for health
professionals to understand the information needed to generate the most accurate and useful
codes so that they are better able to provide this information as a part of the medical record, even
if it is recorded by hand.
ICD-10 codes contained a letter of the alphabet in the first position, which indicated the chapter
in which the category was classified. (The codes for ICD-10 mental and behavioural disorders
all began with the letter “F”.) This was sufficient for the 22 chapters in ICD-10. All the other
characters in the ICD-10 codes were limited to numbers, which imposed a limit of 10 subdivisions
31
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
at each level corresponding to each digit in the diagnostic code. Moreover, ICD-10 allowed for
the coding of only limited disorder-specific clinical information within a diagnostic code via the
provision of specifiers and subtypes that could be codified in the fourth, fifth or sixth characters
in an ICD-10 code.
ICD-11, like ICD-10 and its predecessors, also conveys diagnostic information based on the
various positions and values of alphanumeric characters within a diagnostic code. The first
character of an ICD-11 code indicates the top-level chapter; for example, if the first character is
a “6”, the code is found in the mental, behavioural and neurodevelopmental disorders chapter.
The second and third characters taken together indicate the diagnostic class or grouping (e.g. 6A7
for depressive disorders, 6B0 for anxiety and fear-related disorders). The fourth character typically
indicates the specific disorder within that class (e.g. 6A70 for single episode depressive disorder,
6A71 for recurrent depressive disorder), but in cases in which these number more than 10, letters
of the alphabet are used after the digits 0–9 are exhausted. For example, the fourth character in the
ICD-11 codes for disorders due to substance use indicates the substance class. Because ICD-11
recognizes 14 different specific substance classes, the fourth character codes for the last four
substance classes required resorting to letters (e.g. the code for disorders due to use of volatile
inhalants is 6C4B.)
The fifth character (following a decimal point) generally indicates subtypes or specifiers applicable
to that diagnosis (e.g. 6A70.0 for single episode, mild; 6A70.1 for single episode, moderate,
without psychotic symptoms; 6A70.2 for single episode, moderate, with psychotic symptoms).
The ICD-11 codes for some disorders with more complicated systems for specifiers might require
the use of a sixth character. For example, the fifth character for acute and transient psychotic
disorder indicates whether it is the first episode (6A23.0) or one of multiple episodes (6A23.1).
Indicating whether it is currently symptomatic or in remission requires a sixth character. That is,
for 6A23.0 Acute and transient psychotic disorder, first episode, 6A23.00 is currently symptomatic;
6A23.01 is currently in partial remission; and 6A23.02 is currently in full remission. ICD-11
refers to this method of providing unique codes for all possible combinations of first or multiple
episodes and currently symptomatic or partial remission or full remission for acute and transient
psychotic disorder as “precoordination”.
ICD-11 offers an additional coding convention that goes beyond just capturing clinical
information within the confines of a single diagnostic code by allowing additional codes to be
linked to the initial diagnostic code for the purpose of indicating additional clinically significant
features. ICD-11 refers to this method of combining codes as “postcoordination”. One type of
postcoordination used in the chapter on mental, behavioural and neurodevelopmental disorders
involves appending codes that indicate specific symptomatic or course presentations that are
applicable only to diagnoses within a particular diagnostic grouping. These include symptomatic
manifestations of primary psychotic disorders; symptomatic and course presentations for mood
episodes in mood disorders; prominent personality traits or patterns in personality disorders;
and behavioural or psychological disturbances in dementia. For example, the diagnostic codes
indicating symptomatic and course presentations for mood episodes applicable only to mood
disorders include the following
• 6A80.0 indicates the presence of prominent anxiety symptoms during a mood episode.
• 6A80.1 indicates that two or more panic attacks have occurred during a mood episode.
• 6A80.2 indicates that a current depressive episode is persistent.
• 6A80.3 indicates that a current depressive episode is characterized by melancholia.
• 6A80.4 indicates a seasonal pattern of mood episode onset and remission.
• 6A80.5 indicates a rapid cycling course (applicable only to bipolar type I and bipolar type II
disorders).
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
The diagnostic code 6A71.3/6A80.3, for example, indicates recurrent depressive disorder, current
episode severe, without psychotic symptoms (6A71.3), with melancholia (6A80.3).
Another form of postcoordination is through the use of “extension codes”, which are generic
codes that can be applied across the categories in the different chapters of ICD-11. Extension
codes for severity – none (XS8H), mild (XS5W), moderate (XS0T) and severe (XS25) – are
used in several places in the ICD-11 chapter on mental, behavioural and neurodevelopmental
disorders. Extension codes are appended to the diagnostic code they are modifying using an
ampersand (&). For example, 6D80&XS0T is the code for dementia due to Alzheimer disease
(6D80) of moderate severity (XS0T). Extension codes can also be used to indicate a provisional
diagnosis (XY7Z) or to designate a differential diagnosis (XY75). For example, 6A02&XY7Z is
the code to indicate a provisional diagnosis (XY7Z) of autism spectrum disorder (6A02).
The coding for schizophrenia illustrates how a combination of precoordinated and postcoordinated
codes, including extension codes for severity, can be used to characterize course and symptomatic
manifestations more fully. Clinical course of schizophrenia is indicated using a combination of
fifth-character codes (“0” for first episode, “1” for multiple episodes, “2” for continuous course)
and sixth-character codes (“0” for currently symptomatic, “1” for in partial remission, “2” for in
full remission). Dimensional profiles of current symptomatic manifestations can be indicated by
adding codes from the symptomatic manifestations of primary psychotic disorders that represent
specific symptom domains:
• 6A25.0 for positive symptoms;
• 6A25.1 for negative symptoms;
• 6A25.2 for depressive mood symptoms;
• 6A25.3 for manic mood symptoms;
• 6A25.4 for psychomotor symptoms; and
• 6A25.5 for cognitive symptoms.
The above codes for symptomatic manifestations of primary psychotic disorders can be used in
combination with extension codes to indicate the severity of each symptom domain, respectively,
thus providing a symptomatic profile of the presenting symptoms for schizophrenia for a
particular individual at a particular point in time. The web-based browser for ICD-11 for MMS4
can be used to construct the diagnostic coding for those disorders with complex combinations of
specifiers and extensions. For example, schizophrenia, first episode, currently symptomatic with
moderate positive symptoms, with severe negative symptoms, absent depressed mood symptoms,
absent manic mood symptoms, mild psychomotor symptoms and severe cognitive symptoms
yields the following combined diagnostic code:
6A20.00/6A25.0&XS0T/6A25.1&XS25/6A25.2&XS8H/6A25.3&XS8H/6A25.4&XS5W/6A25.5&XS25
As indicated, generating and interpreting this type of complex, multipart code will be most
feasible for relatively sophisticated electronic health information systems. It is not expected that
such complex codes will be used routinely by individual clinicians recording diagnoses by hand,
for example.
Coding of mental disorders caused by health conditions not classified
under mental, behavioural and neurodevelopmental disorders
ICD-11, as was the case with ICD-10, requires that two diagnostic codes be given for symptomatic
presentations of mental disorders that are judged to be a manifestation of a health condition (i.e.
disorder, disease or injury) classified outside Chapter 6.
ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS) [website]. Geneva: World Health Organization; 2023 (https://ICD.who.
int/browse11/l-m/en#/).

06 - Secondary parenting
Secondary parenting
33
Using the CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders in clinical settings
One code from the mental, behavioural and neurodevelopmental disorders chapter indicates
the mental disorder diagnosis, and a second code indicates the etiological medical condition.
Note that the CDDR often use the generic term “medical condition” to refer to health conditions
that are not mental disorders (i.e. not classified in the chapter on mental, behavioural and
neurodevelopmental disorders). This is only a shorthand; it is not intended to suggest that mental,
behavioural and neurodevelopmental disorders are not health conditions.
The convention of double coding as it applies to the grouping of secondary mental or behavioural
syndromes associated with disorders and diseases classified elsewhere involves assigning the
code for the presumed underlying disorder or disease in combination with the code for the
phenomenologically relevant secondary mental disorder. The earlier example of presentation
consisting of depressive symptoms similar to those of a depressive episode that are judged to
be due to hypothyroidism would be indicated by combining the diagnostic code for secondary
mood syndrome, with depressive symptoms (6E62.0) with the appropriate diagnostic code
from the hypothyroidism grouping – for example, transient congenital hypothyroidism
(5A00.03), yielding the combination code 6E62.0/5A00.03. This coding convention also applies
to neurocognitive disorders such as dementia due to different types of underlying diseases; for
example, frontotemporal dementia requires two codes: 6D83 for the syndrome of frontotemporal
dementia plus 8A23 frontotemporal lobar degeneration from Chapter 8 on diseases of the
nervous system, yielding a combined code of 6D83/8A23. Importantly, the order of the codes
being combined is not meaningful in this situation; it is not necessary to list the primary disorder
first. That is, 6D83/8A23 has the same meaning as 8A23/6D83.
Secondary parenting
The ICD-11 classification is divided into 25 chapters, generally based on organ system (e.g.
diseases of the digestive system), anatomic location (e.g. diseases of the ear and mastoid process),
common pathophysiological process (e.g. certain infectious or parasitic disorders; neoplasms)
or medical specialty (e.g. separating diseases of the nervous system from mental, behavioural
and neurodevelopmental disorders). Many diseases in ICD-11 could have been placed in more
than one chapter (e.g. pancreatic cancer could have been plausibly placed in either the diseases
of the digestive system or the neoplasms chapter). ICD-11 acknowledges this fact by sometimes
locating the same disorder in two (or more) chapters, with one of the chapters considered to be
the “primary parent” and other chapter(s) termed “secondary parent(s)”.
For example, the grouping of primary tics and tic disorders is listed in both Chapter 8 on diseases
of the nervous system (within the movement disorders grouping) and the mental, behavioural
and neurodevelopmental disorders chapter (within the neurodevelopmental disorders grouping).
They are primary-parented in Chapter 8 on diseases of the nervous system and secondary-parented
in the mental, behavioural and neurodevelopmental disorders chapter. The code number in both
instances is the same and corresponds to the primary parent. For example, the code for Tourette
syndrome is 8A05.00. The “8” in the first digit of the code indicates that it is primary-parented in
Chapter 8 on diseases of the nervous system. The same code (8A05.00) is retained when Tourette
syndrome appears as a part of the grouping of neurodevelopmental disorders in Chapter 6.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

05 - List of categories

01 - Neurodevelopmental disorders
Neurodevelopmental disorders
35
List of categories
List of categories
Neurodevelopmental disorders
ICD-11 Mental, behavioural and neurodevelopmental
disorders
Note: the following list contains all the available codes in the ICD-11 chapter on mental,
behavioural and neurodevelopmental disorders.
As described in the section of this manual on using the CDDR for ICD-11 mental, behavioural and
neurodevelopmental disorders (p. 21), ICD-11 uses secondary parenting to cross-list categories
from other parts of the classification that share important primary clinical features or other linkages
with the disorders contained in a particular grouping. This most commonly involves substanceinduced mental disorders and secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere, which are also classified in Chapter 6. In several cases,
however, this involves categories from other chapters of ICD-11 (e.g. the inclusion of primary tics
and tic disorders from Chapter 8 on disorders of the nervous system with neurodevelopmental
disorders). These secondary-parented categories also appear in the list below with the groupings
to which they are cross-listed, in grey font.
In ICD-11, postcoordination is a mechanism for allowing additional codes to be linked to the initial
diagnostic code to identify additional clinically significant features of the clinical presentation.
See the section on using the CDDR for ICD-11 mental, behavioural and neurodevelopmental
disorders (p. 21). Postcoordination options for each disorder grouping appear also appear in the
list below, in boxes.
In some cases, ellipses (…) are used to improve the readability of the list by avoiding repetition
of the disorder name. When used, ellipses signify the category name that appears in the level
immediately above. For example, below 6A01.2 Developmental language disorder, the title for
6A01.20 appears as “… with impairment of receptive and expressive language” rather using
the full name of the category, “6A01.20 Developmental language disorder with impairment of
receptive and expressive language”.
Disorders of intellectual development
Specify severity:
6A00.0
Disorder of intellectual development, mild
6A00.1
Disorder of intellectual development, moderate
6A00.2
Disorder of intellectual development, severe
6A00.3
Disorder of intellectual development, profound
6A00.4
Disorder of intellectual development, provisional
6A00.Z
Disorder of intellectual development, unspecified
6A00
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
For all the above Autism Spectrum Disorder (6A02.x) categories, specify whether:
6A02.x0 without loss of previously acquired skills
6A02.x1 with loss of previously acquired skills
Developmental speech and language disorders
6A01.0
Developmental speech sound disorder
6A01.1
Developmental speech fluency disorder
6A01.2
Developmental language disorder
Specify areas of language impairment:
6A01.20
… with impairment of receptive and expressive language
6A01.21
… with impairment of mainly expressive language
6A01.22
… with impairment of mainly pragmatic language
6A01.23
… with other specified language impairment
6A01.Y
Other specified developmental speech or language disorder
6A01.Z
Developmental speech or language disorder, unspecified
Autism spectrum disorder
Specify whether there is a co-occurring disorder or intellectual development and level of functional
language impairment:
6A02.0
… without disorder of intellectual development and with mild or no
impairment of functional language
6A02.1
… with disorder of intellectual development and with mild or no impairment
of functional language
6A02.2
… without disorder of intellectual development and with impaired functional
language
6A02.3
… with disorder of intellectual development and with impaired functional
language
6A02.5
… with disorder of intellectual development and with complete, or almost
complete, absence of functional language
6A02.Y Other specified autism spectrum disorder
6A02.Z Autism spectrum disorder, unspecified
6A02
6A01
Developmental learning disorder
Specify area(s) of learning impairment:
6A03.0
… with impairment in reading
6A03.1
… with impairment in written expression
6A03.2
… with impairment in mathematics
6A03.3
… with other specified impairment of learning
6A03.Z
… unspecified
Developmental motor coordination disorder
6A03
6A04
37
List of categories
Attention deficit hyperactivity disorder
Specify characteristics of clinical presentation:
6A05.0
… with predominantly inattentive presentation
6A05.1
… with predominantly hyperactive-impulsive presentation
6A05.2
… with combined presentation
6A05.Y
… with other specified presentation
6A05.Z
… presentation unspecified
Stereotyped movement disorder
Specify presence of self-injurious behaviours:
6A06.0
… without self-injury
6A06.1
… with self-injury
6A06.Z
… unspecified
Other specified neurodevelopmental disorder
Neurodevelopmental disorder, unspecified
Secondary-parented categories
From Chapter 8 on diseases of the nervous system:
Primary tics and tic disorders
8A05.00
Tourette syndrome
8A05.01
Chronic motor tic disorder
8A05.02
Chronic phonic tic disorder
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary neurodevelopmental syndrome
6E60.0
Secondary speech or language syndrome
6E60.Y
Other specified secondary neurodevelopmental syndrome
6E60.Z
Secondary neurodevelopmental syndrome, unspecified
6E60
6A05
6A06
6A0Y
6A0Z
8A05.0

02 - Schizophrenia and other primary psychotic dis
Schizophrenia and other primary psychotic disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Schizophrenia and other primary psychotic disorders
Schizophrenia
Specify course:
6A20.0
Schizophrenia, first episode
Specify current presentation:
6A20.00
… currently symptomatic
6A20.01
… in partial remission
6A20.02
… in full remission
6A20.0Z
… unspecified
6A20.1
Schizophrenia, multiple episodes
Specify current presentation:
6A20.10
… currently symptomatic
6A20.11
… in partial remission
6A20.12
… in full remission
6A20.1Z
… unspecified
6A20.2
Schizophrenia, continuous
Specify current presentation:
6A20.20
… currently symptomatic
6A20.21
… in partial remission
6A20.02
… in full remission
6A20.2Z
… unspecified
6A20.Y
Other specified episode of schizophrenia
6A20.Z
Schizophrenia, episode unspecified
Schizoaffective disorder
Specify course:
6A21.0
Schizoaffective disorder, first episode
Specify current presentation:
6A20.00
… currently symptomatic
6A20.01
… in partial remission
6A20.02
… in full remission
6A20.0Z
… unspecified
6A21.1
Schizoaffective disorder, multiple episodes
Specify current presentation:
6A21.10
… currently symptomatic
6A21.11
… in partial remission
6A21.12
… in full remission
6A21.1Z
… unspecified
6A20
6A21
39
List of categories
6A21.2
Schizoaffective disorder, continuous
Specify current presentation:
6A21.20
… currently symptomatic
6A21.21
… in partial remission
6A21.22
… in full remission
6A21.2Z
… unspecified
6A21.Y
Other specified schizoaffective disorder
6A21.Z
Schizoaffective disorder, unspecified
Schizotypal disorder
Acute and transient psychotic disorder
Specify course:
6A23.0
Acute and transient psychotic disorder, first episode
Specify current presentation:
6A23.00
… currently symptomatic
6A23.01
… in partial remission
6A23.02
… in full remission
6A23.0Z
… unspecified
6A23.1
Acute and transient psychotic disorder, multiple episodes
Specify current presentation:
6A23.10
… currently symptomatic
6A23.11
… in partial remission
6A23.12
… in full remission
6A23.1Z
… unspecified
6A23.Y
Other specified acute and transient psychotic disorder
6A23.Z
Acute and transient psychotic disorder, unspecified
Delusional disorder
Specify current presentation:
6A24.0
… currently symptomatic
6A24.1
… in partial remission
6A24.2
… in full remission
6A24.Z
… unspecified
Other specified primary psychotic disorder
Schizophrenia or other primary psychotic disorder, unspecified
6A22
6A23
6A24
6A2Y
6A2Z
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Postcoordination for schizophrenia and other primary psychotic disorders
For all above categories in the schizophrenia and other primary psychotic disorders
grouping, specify symptomatic manifestations of primary psychotic disorders to
describe current clinical presentation:
6A25.0
Positive symptoms
Specify severity:
6A25.0&XS8H
None
6A25.0&XS5W
Mild
6A25.0&XS0T
Moderate
6A25.0&XS25
Severe
6A25.1
Negative symptoms
Specify severity:
6A25.1&XS8H
None
6A25.1&XS5W
Mild
6A25.1&XS0T
Moderate
6A25.1&XS25
Severe
6A25.2
Depressive mood symptoms
Specify severity:
6A25.2&XS8H
None
6A25.2&XS5W
Mild
6A25.2&XS0T
Moderate
6A25.2&XS25
Severe
6A25.3
Manic mood symptoms
Specify severity:
6A25.3&XS8H None
6A25.3&XS5W
Mild
6A25.3&XS0T
Moderate
6A25.3&XS25
Severe
6A25.4
Psychomotor symptoms
Specify severity:
6A25.4&XS8H
None
6A25.4&XS5W
Mild
6A25.4&XS0T
Moderate
6A25.4&XS25
Severe
6A25.5
Cognitive symptoms
Specify severity:
6A25.5&XS8H
None
6A25.5&XS5W
Mild
6A25.5&XS0T
Moderate
6A25.5&XS25
Severe
Secondary-parented categories
From disorders due to substance use:
Substance-induced psychotic disorders
Specify substance class:
Alcohol-induced psychotic disorder
6C40.6
Specify clinical presentation:
6C40.60
… with hallucinations
6C40.61
… with delusions
6C40.62
… with mixed psychotic symptoms
6C40.6Z
… unspecified
Cannabis-induced psychotic disorder
6C41.6
Synthetic cannabinoid-induced psychotic disorder
6C42.6
Opioid-induced psychotic disorder
6C43.6
Sedative, hypnotic or anxiolytic-induced psychotic disorder
6C44.6
Cocaine-induced psychotic disorder
6C45.6
Specify clinical presentation:
6C45.60
… with hallucinations
6C45.61
… with delusions
6C45.62
… with mixed psychotic symptoms
6C45.6Z
… unspecified
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Stimulant-induced psychotic disorder, including amfetamines,
methamfetamine and methcathinone
Specify clinical presentation:
6C46.60
… with hallucinations
6C46.61
… with delusions
6C46.62
… mixed psychotic symptoms
6C46.6Z
… unspecified
Synthetic cathinone-induced psychotic disorder
Specify clinical presentation:
6C47.60
… with hallucinations
6C47.61
… with delusions
6C47.62
… with mixed psychotic symptoms
6C47.6Z
… unspecified
Hallucinogen-induced psychotic disorder
Volatile inhalant-induced psychotic disorder
MDMA or related drug-induced psychotic disorder
Dissociative drug-induced psychotic disorder, including ketamine and
phencyclidine (PCP)
Psychotic disorder induced by other specified psychoactive
substance
Psychotic disorder induced by multiple specified psychoactive
substances
Psychotic disorder induced by unknown or unspecified specified
psychoactive substances
6C46.6
6C47.6
6C49.5
6C4B.6
6C4D.5
6C4C.6
6C4E.6
6C4F.6
6C4G.6

03 - Catatonia
Catatonia
43
List of categories
6E61
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary psychotic syndrome
Specify clinical presentation:
6E61.0
… with hallucinations
6E61.1
… with delusions
6E61.2
… with hallucinations and delusions
6E61.3
… with unspecified symptoms
Catatonia
Catatonia associated with another mental disorder
Catatonia induced by substances or medications
Catatonia, unspecified
Secondary-parented category
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary catatonia syndrome
6A40
6A41
6A4Z
6E69
6E61

04 - Mood disorders
Mood disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Postcoordination for bipolar type I disorder:
For all above bipolar type I disorder categories, specify additional features of current
presentation or course by using additional code(s) if applicable:
6A80.0 with prominent anxiety symptoms
6A80.1 with panic attacks
6A80.2 current depressive episode persistent
6A80.3 current depressive episode with melancholia
6A80.4 with seasonal pattern of mood episode onset
6A80.5 with rapid cycling
For all above bipolar type I disorder current or most recent episodes, specify if episode
onset was during pregnancy or within 6 weeks after delivery by using additional
code:
6E20 Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, without psychotic symptoms
6E21 Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, with psychotic symptoms
6E2Z Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, unspecified
Mood disorders
Bipolar and related disorders
Bipolar type I disorder
Specify type of current or most recent episode and/or remission:
6A60.0
… current episode manic, without psychotic symptoms
6A60.1
… current episode manic, with psychotic symptoms
6A60.2
… current episode hypomanic
6A60.3
… current episode depressive, mild
6A60.4
… current episode depressive, moderate, without psychotic symptoms
6A60.5
… current episode depressive, moderate, with psychotic symptoms
6A60.6
… current episode depressive, severe, without psychotic symptoms
6A60.7
… current episode depressive, severe, with psychotic symptoms
6A60.8
… current episode depressive, unspecified severity
6A60.9
… current episode mixed, without psychotic symptoms
6A60.A
… current episode mixed, with psychotic symptoms
6A60.B
… currently in partial remission, most recent episode manic or hypomanic
6A60.C
… currently in partial remission, most recent episode depressive
6A60.D
… currently in partial remission, most recent episode mixed
6A60.E
… currently in partial remission, most recent episode unspecified
6A60.F
… currently in full remission
6A60.Y
Other specified bipolar type I disorder
6A60.Z
Bipolar type I disorder, unspecified
6A60
45
List of categories
Bipolar type II disorder
Specify type of current or most recent episode and/or remission:
6A61.0
… current episode hypomanic
6A61.1
… current episode depressive, mild
6A61.2
… current episode depressive, moderate, without psychotic symptoms
6A61.3
… current episode depressive, moderate, with psychotic symptoms
6A61.4
… current episode depressive, severe, without psychotic symptoms
6A61.5
… current episode depressive, severe, with psychotic symptoms
6A61.6
… current episode depressive, unspecified severity
6A61.7
… currently in partial remission, most recent episode hypomanic
6A61.8
… currently in partial remission, most recent episode depressive
6A61.9
… currently in partial remission, most recent episode unspecified
6A61.A
… currently in full remission
6A61.Y
Other specified bipolar type II disorder
6A61.Z
Bipolar type II disorder, unspecified
6A61
Postcoordination for bipolar type II disorder
For all above bipolar type II disorder categories, specify additional features of current
presentation or course by using additional code(s) if applicable:
6A80.0 with prominent anxiety symptoms
6A80.1 with panic attacks
6A80.2 current depressive episode persistent
6A80.3 current depressive episode with melancholia
6A80.4 with seasonal pattern of mood episode onset
6A80.5 with rapid cycling
For all above bipolar type II disorder current or most recent episodes, specify
if episode onset was during pregnancy or within 6 weeks after delivery by using
additional code:
6E20 Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, without psychotic symptoms
6E21 Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, with psychotic symptoms
6E2Z Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, unspecified
Cyclothymic disorder
Other specified bipolar or related disorder
Bipolar or related disorder, unspecified
6A62
6A6Y
6A6Z
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Postcoordination for single episode depressive disorder
For all above single episode depressive disorder categories, specify additional features
of current presentation or course by using additional code(s) if applicable:
6A80.0
with prominent anxiety symptoms
6A80.1
with panic attacks
6A80.2
current depressive episode persistent
6A80.3
current depressive episode with melancholia
6A80.4
with seasonal pattern of mood episode onset
For all above single episode depressive disorder current or most recent episodes,
specify if episode onset was during pregnancy or within 6 weeks after delivery by
using additional code:
6E20
Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, without psychotic symptoms
6E21
Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, with psychotic symptoms
6E2Z
Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, unspecified
Depressive disorders
Single episode depressive disorder
Specify severity or remission of current episode:
6A70.0
… mild
6A70.1
… moderate, without psychotic symptoms
6A70.2
… moderate, with psychotic symptoms
6A70.3
… severe, without psychotic symptoms
6A70.4
… severe, with psychotic symptoms
6A70.5
… unspecified severity
6A70.6
… currently in partial remission
6A70.7
… currently in full remission
6A70.Y
Other specified single episode depressive disorder
6A70.Z
Single episode depressive disorder, unspecified
6A70
Recurrent depressive disorder
Specify severity or remission of current episode:
6A71.0
… current episode mild
6A71.1
… current episode moderate, without psychotic symptoms
6A71.2
… current episode moderate, with psychotic symptoms
6A71.3
… current episode severe, without psychotic symptoms
6A71
6A71.4
… current episode severe, with psychotic symptoms
6A71.5
… current episode, unspecified severity
6A71.6
… currently in partial remission
6A71.7
… currently in full remission
6A71.Y
Other specified recurrent depressive disorder
6A71.Z
Recurrent depressive disorder, unspecified
Postcoordination for recurrent depressive disorder
For all above recurrent depressive disorder categories, specify additional features of
current presentation or course by using additional code(s) if applicable:
6A80.0
with prominent anxiety symptoms
6A80.1
with panic attacks
6A80.2
current depressive episode persistent
6A80.3
current depressive episode with melancholia
6A80.4
with seasonal pattern of mood episode onset
For all above recurrent depressive disorder current or most recent episodes, specify
if episode onset was during pregnancy or within 6 weeks after delivery by using
additional code:
6E20
Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, without psychotic symptoms
6E21
Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, with psychotic symptoms
6E2Z
Mental and behavioural disorders associated with pregnancy, childbirth
or the puerperium, unspecified
Dysthymic disorder
6A72
6A73
Mixed depressive and anxiety disorder
Other specified depressive disorder
6A7Y
Depressive disorder, unspecified
6A7Z
Other specified mood disorder
6A8Y
Mood disorder, unspecified
6A8Z
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Secondary-parented categories
From disorders due to substance use:
Substance-induced mood disorders
Specify substance class:
Alcohol-induced mood disorder
Specify clinical presentation:
6C40.700
… with depressive symptoms
6C40.701
… with manic symptoms
6C40.702
… with mixed depressive and manic symptoms
6C40.70Z
… unspecified
Cannabis-induced mood disorder
Specify clinical presentation:
6C41.700
… with depressive symptoms
6C41.701
… with manic symptoms
6C41.702
… with mixed depressive and manic symptoms
6C41.70Z
… unspecified
Synthetic cannabinoid-induced mood disorder
Specify clinical presentation:
6C42.700
… with depressive symptoms
6C42.701
… with manic symptoms
6C42.702
… with mixed depressive and manic symptoms
6C42.70Z
… unspecified
Opioid-induced mood disorder
Specify clinical presentation:
6C43.700
… with depressive symptoms
6C43.701
… with manic symptoms
6C43.702
… with mixed depressive and manic symptoms
6C43.70Z
… unspecified
6C40.70
6C41.70
6C42.70
6C43.70
Sedative, hypnotic or anxiolytic-induced mood disorder
6C44.70
Specify clinical presentation:
6C44.700
… with depressive symptoms
6C44.701
… with manic symptoms
6C44.702
… with mixed depressive and manic symptoms
6C44.70Z
… unspecified
Cocaine-induced mood disorder
6C45.70
Specify clinical presentation:
6C45.700
… with depressive symptoms
6C45.701
… with manic symptoms
6C45.702
… with mixed depressive and manic symptoms
6C45.70Z
… unspecified
Stimulant-induced mood disorder, including amfetamines,
methamfetamine and methcathinone
6C46.70
Specify clinical presentation:
6C46.700
… with depressive symptoms
6C46.701
… with manic symptoms
6C46.702
… with mixed depressive and manic symptoms
6C46.70Z
… unspecified
6C47.70
Synthetic cathinone-induced mood disorder
Specify clinical presentation:
6C47.700
… with depressive symptoms
6C47.701
… with manic symptoms
6C47.702
… with mixed depressive and manic symptoms
6C47.70Z
… unspecified
6C49.60
Hallucinogen-induced mood disorder
Specify clinical presentation:
6C49.700
… with depressive symptoms
6C49.701
… with manic symptoms
6C49.702
… with mixed depressive and manic symptoms
6C49.70Z
… unspecified
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Volatile inhalant-induced mood disorder
Specify clinical presentation:
6C4B.700
… with depressive symptoms
6C4B.701
… with manic symptoms
6C4B.702
… with mixed depressive and manic symptoms
6C4B.70Z
… unspecified
MDMA or related drug-induced mood disorder, including MDA
Specify clinical presentation:
6C4C.700
… with depressive symptoms
6C4C.701
… with manic symptoms
6C4C.702
… with mixed depressive and manic symptoms
6C4C.70Z
… unspecified
Dissociative drug-induced mood disorder, including ketamine and
PCP
Specify clinical presentation:
6C4D.700
… depressive symptoms
6C4D.701
… with manic symptoms
6C4D.702
… with mixed depressive and manic symptoms
6C4D.70Z
… unspecified
Mood disorder induced by other specified psychoactive substance
Specify clinical presentation:
6C4E.700
… with depressive symptoms
6C4E.701
… with manic symptoms
6C4E.702
… with mixed depressive and manic symptoms
6C4E.70Z
… unspecified
Mood disorder induced by multiple specified psychoactive
substances
Specify clinical presentation:
6C4F.700
… with depressive symptoms
6C4F.701
… with manic symptoms
6C4F.702
… with mixed depressive and manic symptoms
6C4F.70Z
… unspecified
Mood disorder induced by unknown or unspecified psychoactive
substances
Specify clinical presentation:
6C4G.700
… with depressive symptoms
6C4G.701
… with manic symptoms
6C4D.60
6C4E.70
6C4F.70
6C4G.70
6C4B.70
6C4C.70

05 - Anxiety and fear related disorders
Anxiety and fear-related disorders
51
List of categories
6C4G.702
… with mixed depressive and manic symptoms
6C4G.70Z
… unspecified
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary mood syndrome
Specify clinical presentation:
6E62.0
… with depressive symptoms
6E62.1
… with manic symptoms
6E62.2
… with mixed symptoms
6E62.3
… with unspecified symptoms
Anxiety and fear-related disorders
Generalized anxiety disorder
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B00/MB23.H
Generalized anxiety disorder with panic attacks
Panic disorder
Agoraphobia
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B02/MB23.H
Agoraphobia with panic attacks
Specific phobia
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B03/MB23.H
Specific phobia with panic attacks
Social anxiety disorder
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B04/MB23.H
Social anxiety disorder with panic attacks
Separation anxiety disorder
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B05/MB23.H
Separation anxiety disorder with panic attacks
6B00
6B01
6B02
6B03
6B04
6B05
6E62
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Selective mutism
Other specified anxiety or fear-related disorder
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B0Y/MB23.H
Other specified anxiety and fear-related disorder with panic attacks
Anxiety or fear-related disorder, unspecified
Specify presence of panic attacks without co-occurring panic disorder diagnosis
6B0Z/MB23.H
Anxiety or fear-related disorder, unspecified, with panic attacks
Secondary-parented categories
From obsessive-compulsive and related disorders:
Hypochondriasis (health anxiety disorder)
Specify level of insight:
6B23.0
Hypochondriasis with fair to good insight
6B23.1
Hypochondriasis with poor to absent insight
From disorders due to substance use:
Substance-induced anxiety disorders
Specify substance class:
Alcohol-induced anxiety disorder
Cannabis-induced anxiety disorder
Synthetic cannabinoid-induced anxiety disorder
Opioid-induced anxiety disorder
6B23
6C40.71
6C41.71
6C42.71
6B06
6B0Y
6B0Z
6C43.71
53
List of categories
Sedative, hypnotic or anxiolytic-induced anxiety disorder
Cocaine-induced anxiety disorder
Stimulant-induced anxiety disorder, including amfetamines,
methamfetamine and methcathinone
Synthetic cathinone-induced anxiety disorder
Caffeine-induced anxiety disorder
Hallucinogen-induced anxiety disorder
Volatile inhalant-induced anxiety disorder
MDMA or related drug-induced anxiety disorder
Dissociative drug-induced anxiety disorder, including ketamine and
PCP
Anxiety disorder induced by other specified psychoactive substance
Anxiety disorder induced by multiple specified psychoactive
substances
Anxiety disorder induced by unknown or unspecified specified
psychoactive substances
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary anxiety syndrome
6C44.71
6C45.71
6C46.71
6C47.71
6C48.71
6C49.71
6C40.71
6C4C.71
6C4D.71
6C4E.71
6C4F.71
6C4G.71
6E63

06 - Obsessive compulsive and related disorders
Obsessive-compulsive and related disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Obsessive-compulsive and related disorders
Obsessive-compulsive disorder
Specify level of insight:
6B20.0
Obsessive-compulsive disorder with fair to good insight
6B20.1
Obsessive-compulsive disorder with poor to absent insight
6B20.Z
Obsessive-compulsive disorder, unspecified
Body dysmorphic disorder
Specify level of insight:
6B21.0
Body dysmorphic disorder with fair to good insight
6B21.1
Body dysmorphic disorder with poor to absent insight
6B21.Z
Body dysmorphic disorder, unspecified
Olfactory reference disorder
Specify level of insight:
6B22.0
Olfactory reference disorder with fair to good insight
6B22.1
Olfactory reference disorder with poor to absent insight
6B22.Z
Olfactory reference disorder, unspecified
Hypochondriasis (health anxiety disorder)
Specify level of insight:
6B23.0
Hypochondriasis with fair to good insight
6B23.1
Hypochondriasis with poor to absent insight
6B23.Z
Hypochondriasis, unspecified
Hoarding disorder
Specify level of insight:
6B24.0
Hoarding disorder with fair to good insight
6B24.1
Hoarding disorder with poor to absent insight
6B24.Z
Hoarding disorder, unspecified
Body-focused repetitive behaviour disorders
6B25.0
Trichotillomania (hair-pulling disorder)
6B25.1
Excoriation (skin-picking) disorder
6B20
6B21
6B22
6B23
6B24
6B25
55
List of categories
6B25.Y
Other specified body-focused repetitive behaviour disorder
6B25.Z
Body-focused repetitive behaviour disorder, unspecified
Other specified obsessive-compulsive or related disorder
Obsessive-compulsive or related disorder, unspecified
Secondary-parented categories
From Chapter 8 on diseases of the nervous system:
Tourette syndrome
From disorders due to substance use:
Substance-induced obsessive-compulsive and related disorders
Specify substance class:
6C45.72
Cocaine-induced obsessive-compulsive or related disorder
6C46.72
Stimulant-induced obsessive-compulsive or related disorder, including
amfetamines, methamfetamine and methcathinone
6C47.72
Synthetic cathinone-induced obsessive-compulsive or related syndrome
6C4E.72
Obsessive-compulsive or related disorder induced by other specified
psychoactive substance
6C4F.72
Obsessive-compulsive or related disorder induced by multiple specified
psychoactive substances
6C4G.72
Obsessive-compulsive or related disorder induced by unknown or
unspecified psychoactive substances
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary obsessive-compulsive or related syndrome
6B2Y
6B2Z
8A05.00
6E64

07 - Disorders specifically associated with stress
Disorders specifically associated with stress
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Disorders specifically associated with stress
Post-traumatic stress disorder
Complex post-traumatic stress disorder
Prolonged grief disorder
Adjustment disorder
Reactive attachment disorder
Disinhibited social engagement disorder
Other specified disorder specifically associated with stress
Disorder specifically associated with stress, unspecified
Secondary-parented category
From Chapter 21 on factors influencing health status or contact with
health services
Acute stress reaction
6B42
6B44
6B45
6B43
6B41
6B40
6B4Y
6B4Z
QE84

08 - Dissociative disorders
Dissociative disorders
57
List of categories
Dissociative neurological symptom disorder
Specify clinical presentation:
6B60.0
… with visual disturbance
6B60.1
… with auditory disturbance
6B60.2
… with vertigo or dizziness
6B60.3
… with other sensory disturbance
6B60.4
… with non-epileptic seizures
6B60.5
… with speech disturbance
6B60.6
… with paresis or weakness
6B60.7
… with gait disturbance
6B60.8
… with movement disturbance
6B60.80
… with chorea
6B60.81
… with myoclonus
6B60.82
… with tremor
6B60.83
… with dystonia
6B60.84
… with facial spasm
6B60.85
… with parkinsonism
6B60.8Y
… with other specified movement disturbance
6B60.8Z
… with unspecified movement disturbance
6B60.9
… with cognitive symptoms
6B60.Y
… with other specified symptoms
6B60.Z
… with unspecified symptoms
Dissociative amnesia
Specify presence of dissociative fugue:
6B61.0
… with dissociative fugue
6B61.1
… without dissociative fugue
6B61.Z
… unspecified
Trance disorder
Possession trance disorder
Dissociative identity disorder
Partial dissociative identity disorder
Dissociative disorders
6B60
6B61
6B62
6B64
6B65
6B63

09 - Feeding and eating disorders
Feeding and eating disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Depersonalization-derealization disorder
Other specified dissociative disorder
Dissociative disorder, unspecified
Secondary-parented category
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary dissociative syndrome
6B6Y
6B6Z
6B66
6E65
Feeding and eating disorders
Anorexia nervosa
Specify underweight status:
6B80.0
Anorexia nervosa with significantly low body weight
Specify pattern of weight-related behaviours:
6B80.00
… restricting pattern
6B80.01
… binge-purge pattern
6B80.0Z
… unspecified
6B80.1
Anorexia nervosa with dangerously low body weight
Specify pattern of weight-related behaviours:
6B80.10
… restricting pattern
6B80.11
… binge-purge pattern
6B80.1Z
… unspecified
6B80.2 Anorexia nervosa in recovery with normal body weight
6B80.Y
Other specified anorexia nervosa
6B80.Z
Anorexia nervosa, unspecified
Bulimia nervosa
Binge-eating disorder
6B81
6B82
6B80

10 - Elimination disorders
Elimination disorders
Avoidant-restrictive food intake disorder
6B83
Pica
6B84
Rumination-regurgitation disorder
6B85
Other specified feeding or eating disorder
6B8Y
6B83
Feeding or eating disorder, unspecified
6B8Z
6B84
Elimination disorders
Enuresis
6C00
Specify night-time or daytime occurrence:
6C00.0
Nocturnal enuresis
6C00.1
Diurnal enuresis
6C00.2
Nocturnal and diurnal enuresis
6C00.Z
Enuresis, unspecified
Encopresis
6C01
Specify pattern of faecal soiling:
6C01.0
…with constipation and overflow incontinence
6C01.1
…without constipation and overflow incontinence
6C01.Z
…unspecified
Elimination disorder, unspecified
6B80
List of categories

11 - Disorders of bodily distress or bodily experi
Disorders of bodily distress or bodily experience

12 - Disorders due to substance use and addictive
Disorders due to substance use and addictive behaviours

13 - Disorders due to substance use
Disorders due to substance use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Disorders of bodily distress or bodily experience
Bodily distress disorder
Specify level of severity:
6C20.0
Mild bodily distress disorder
6C20.1
Moderate bodily distress disorder
6C20.2
Severe bodily distress disorder
6C20.Z
Bodily distress disorder, unspecified
Body integrity dysphoria
Other specified disorder of bodily distress or bodily experience
Disorder of bodily distress or bodily experience, unspecified
6C20
6C21
6C2Y
6C2Z
Disorders due to substance use and addictive behaviours
Disorders due to substance use
Disorders due to use of alcohol
6C40.0
Episode of harmful use of alcohol
6C40.1
Harmful pattern of use of alcohol
Specify pattern:
6C40.10
… episodic
6C40.11
… continuous
6C40.1Z
… unspecified
6C40.2
Alcohol dependence
Specify pattern of substance use or remission:
6C40.20
… current use, continuous
6C40.21
… current use, episodic
6C40.22
… early full remission
6C40.23
… sustained partial remission
6C40.24
… sustained full remission
6C40.2Z
… unspecified
6C40
6C40.3
Alcohol intoxication
Specify severity:
6C40.3&XS5W Alcohol intoxication, mild
6C40.3&XS0T Alcohol intoxication, moderate
6C40.3&XS25 Alcohol intoxication, severe
6C40.4
Alcohol withdrawal
Specify clinical presentation:
6C40.40
… uncomplicated
6C40.41
… with perceptual disturbances
6C40.42
… with seizures
6C40.43
… with perceptual disturbances and seizures
6C40.4Z
… unspecified
6C40.5
Alcohol-induced delirium
6C40.6
Alcohol-induced psychotic disorder
Specify clinical presentation:
6C40.60
… with hallucinations
6C40.61
… with delusions
6C40.62
… with mixed psychotic symptoms
6C40.6Z
… unspecified
6C40.70
Alcohol-induced mood disorder
Specify clinical presentation:
6C40.700
… with depressive symptoms
6C40.701
… with manic symptoms
6C40.702
… with mixed depressive and manic symptoms
6C40.70Z
… unspecified
6C40.71
Alcohol-induced anxiety disorder
6C40.Y
Other specified disorder due to use of alcohol
6C40.Z
Disorders due to use of alcohol, unspecified
Disorders due to use of cannabis
6C41
6C41.0
Episode of harmful use of cannabis
6C41.1
Harmful pattern of use of cannabis
Specify pattern:
6C41.10
… episodic
6C41.11
… continuous
6C41.1Z
… unspecified
6C41.2
Cannabis dependence
Specify pattern of substance use or remission:
6C41.20
… current use
6C41.21
… early full remission
6C41.22
… sustained partial remission
6C41.23
… sustained full remission
6C41.2Z
… unspecified
6C41.3
Cannabis intoxication
Specify severity:
6C41.3&XS5W Cannabis intoxication, mild
6C41.3&XS0T Cannabis intoxication, moderate
6C41.3&XS25 Cannabis intoxication, severe
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C41.4
Cannabis withdrawal
6C41.5
Cannabis-induced delirium
6C41.6
Cannabis-induced psychotic disorder
6C41.70
Cannabis-induced mood disorder
Specify clinical presentation:
6C41.700
… with depressive symptoms
6C41.701
… with manic symptoms
6C41.702
… with mixed depressive and manic symptoms
6C41.70Z
… unspecified
6C41.71
Cannabis-induced anxiety disorder
6C41.Y
Other specified disorder due to use of cannabis
6C41.Z
Disorder due to use of cannabis, unspecified
Disorders due to use of synthetic cannabinoids
6C42.0
Episode of harmful use of synthetic cannabinoids
6C42.1
Harmful pattern of use of synthetic cannabinoids
Specify pattern:
6C42.10
… episodic
6C42.11
… continuous
6C42.1Z
… unspecified
6C42.2
Synthetic cannabinoid dependence
Specify pattern of substance use or remission:
6C42.20
… current use
6C42.21
… early full remission
6C42.22
… sustained partial remission
6C42.23
… sustained full remission
6C42.2Z
… unspecified
6C42.3
Synthetic cannabinoid intoxication
Specify severity:
6C42.3&XS5W Synthetic cannabinoid intoxication, mild
6C42.3&XS0T Synthetic cannabinoid intoxication, moderate
6C42.3&XS25 Synthetic cannabinoid intoxication, severe
6C42.4
Synthetic cannabinoid withdrawal
6C42.5
Synthetic cannabinoid-induced delirium
6C42.6
Synthetic cannabinoid-induced psychotic disorder
6C42.70
Synthetic cannabinoid-induced mood disorder
Specify clinical presentation:
6C42.700
… with depressive symptoms
6C42.701
… with manic symptoms
6C42.702
… with mixed depressive and manic symptoms
6C42.70Z
… unspecified
6C42.71
Synthetic cannabinoid-induced anxiety disorder
6C42.Y
Other specified disorder due to use of synthetic cannabinoids
6C42.Z
Disorder due to use of synthetic cannabinoids, unspecified
6C42
Disorders due to use of opioids
6C43
6C43.0
Episode of harmful use of opioids
6C43.1
Harmful pattern of use of opioids
Specify pattern:
6C43.10
… episodic
6C43.11
… continuous
6C43.1Z
… unspecified
6C43.2
Opioid dependence
Specify pattern of substance use or remission:
6C43.20
… current use
6C43.21
… early full remission
6C43.22
… sustained partial remission
6C43.23
… sustained full remission
6C43.2Z
… unspecified
6C43.3
Opioid intoxication
Specify severity:
6C43.3&XS5W Opioid intoxication, mild
6C43.3&XS0T Opioid intoxication, moderate
6C43.3&XS25 Opioid intoxication, severe
6C43.4
Opioid withdrawal
6C43.5
Opioid-induced delirium
6C43.6
Opioid-induced psychotic disorder
6C43.70
Opioid-induced mood disorder
Specify clinical presentation:
6C43.700
… with depressive symptoms
6C43.701
… with manic symptoms
6C43.702
… with mixed depressive and manic symptoms
6C43.70Z
… unspecified
6C43.71
Opioid-induced anxiety disorder
6C43.Y
Other specified disorder due to use of opioids
6C43.Z
Disorder due to use of opioids, unspecified
Disorders due to use of sedatives, hypnotics or anxiolytics
6C44
6C44.0
Episode of harmful use of sedatives, hypnotics or anxiolytics
6C44.1
Harmful pattern of use of sedatives, hypnotics or anxiolytics
Specify pattern:
6C44.10
… episodic
6C44.11
… continuous
6C44.1Z
… unspecified
6C44.2
Sedative, hypnotic or anxiolytic dependence
Specify pattern of substance use or remission:
6C44.20
… current use
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C44.21
… early full remission
6C44.22
… sustained partial remission
6C44.23
… sustained full remission
6C44.2Z
… unspecified
6C44.3
Sedative, hypnotic or anxiolytic intoxication
Specify severity:
6C44.3&XS5W
Sedative, hypnotic or anxiolytic intoxication, mild
6C44.3&XS0T
Sedative, hypnotic or anxiolytic intoxication,
moderate
6C44.3&XS25
Sedative, hypnotic or anxiolytic intoxication, severe
6C44.4
Sedative, hypnotic or anxiolytic withdrawal
Specify clinical presentation:
6C44.40
… uncomplicated
6C44.41
… with perceptual disturbances
6C44.42
… with seizures
6C44.43
… with perceptual disturbances and seizures
6C44.4Z
… unspecified
6C44.5
Sedative, hypnotic or anxiolytic-induced delirium
6C44.6
Sedative, hypnotic or anxiolytic-induced psychotic disorder
6C44.70
Sedative, hypnotic or anxiolytic-induced mood disorder
Specify clinical presentation:
6C44.700
… with depressive symptoms
6C44.701
… with manic symptoms
6C44.702
… with mixed depressive and manic symptoms
6C44.70Z
… unspecified
6C44.71
Sedative, hypnotic or anxiolytic-induced anxiety disorder
6C44.Y
Other specified disorder due to use of sedatives, hypnotics or
anxiolytics
6C44.Z
Disorder due to use of sedatives, hypnotics or anxiolytics,
unspecified
Disorders due to use of cocaine
6C45.0
Episode of harmful use of cocaine
6C45.1
Harmful pattern of use of cocaine
Specify pattern:
6C45.10
… episodic
6C45.11
… continuous
6C45.1Z
… unspecified
6C45.2
Cocaine dependence
Specify pattern of substance use or remission:
6C45.20
… current use
6C45.21
… early full remission
6C45.22
… sustained partial remission
6C45.23
… sustained full remission
6C45.2Z
… unspecified
6C45
65
List of categories
6C45.3
Cocaine intoxication
Specify severity:
6C45.3&XS5W
Cocaine intoxication, mild
6C45.3&XS0T
Cocaine intoxication, moderate
6C45.3&XS25
Cocaine intoxication, severe
6C45.4
Cocaine withdrawal
6C45.5
Cocaine-induced delirium
6C45.6
Cocaine-induced psychotic disorder
Specify clinical presentation:
6C45.60
… with hallucinations
6C45.61
… with delusions
6C45.62
… with mixed psychotic symptoms
6C45.6Z
… unspecified
6C45.70
Cocaine-induced mood disorder
Specify clinical presentation:
6C45.700
… with depressive symptoms
6C45.701
… with manic symptoms
6C45.702
… with mixed depressive and manic symptoms
6C45.70Z
… unspecified
6C45.71
Cocaine-induced anxiety disorder
6C45.72
Cocaine-induced obsessive-compulsive or related disorder
6C45.73
Cocaine-induced impulse control disorder
6C45.Y
Other specified disorder due to use of cocaine
6C45.Z
Disorder due to use of cocaine, unspecified
Disorders due to use of stimulants, including amfetamines,
methamfetamine and methcathinone
6C46.0
Episode of harmful use of stimulants, including amfetamines, methamfetamine
and methcathinone
6C46.1
Harmful pattern of use of stimulants, including amfetamines,
methamfetamine and methcathinone
Specify pattern:
6C46.10
… episodic
6C46.11
… continuous
6C46.1Z
… unspecified
6C46.2
Stimulant dependence, including amfetamines, methamfetamine and
methcathinone
Specify pattern of substance use or remission:
6C46.20
… current use
6C46.21
… early full remission
6C46.22
… sustained partial remission
6C46.23
… sustained full remission
6C46.2Z
… unspecified
6C46.3
Stimulant intoxication, including amfetamines, methamfetamine and
methcathinone
6C46
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Specify severity:
6C46.3&XS5W
Stimulant intoxication, including amfetamines,
methamfetamine and methcathinone, mild
6C46.3&XS0T
Stimulant intoxication, including amfetamines,
methamfetamine and methcathinone, moderate
6C46.3&XS25
Stimulant intoxication, including amfetamines,
methamfetamine and methcathinone, severe
6C46.4
Stimulant withdrawal, including amfetamines, methamfetamine and
methcathinone
6C46.5
Stimulant-induced delirium, including amfetamines, methamfetamine and
methcathinone
6C46.6
Stimulant-induced psychotic disorder, including amfetamines,
methamfetamine and methcathinone
Specify clinical presentation:
6C46.60
… with hallucinations
6C46.61
… with delusions
6C46.62
… with mixed psychotic symptoms
6C46.6Z
… unspecified
6C46.70
Stimulant-induced mood disorder, including amfetamines, methamfetamine
and methcathinone
Specify clinical presentation:
6C46.700
… with depressive symptoms
6C46.701
… with manic symptoms
6C46.702
… with mixed depressive and manic symptoms
6C46.70Z
… unspecified
6C46.71
Stimulant-induced anxiety disorder, including amfetamines,
methamfetamine and methcathinone
6C46.72
Stimulant-induced obsessive-compulsive or related disorder, including
amfetamines, methamfetamine and methcathinone
6C46.73
Stimulant-induced impulse control disorder, including amfetamines,
methamfetamine and methcathinone
6C46.Y
Other specified disorder due to use of stimulants, including amfetamines,
methamfetamine and methcathinone
6C46.Z
Disorder due to use of stimulants, including amfetamines, methamfetamine
and methcathinone, unspecified
Disorders due to use of synthetic cathinones
6C47.0
Episode of harmful use of synthetic cathinones
6C47.1
Harmful pattern of use of synthetic cathinones
Specify pattern:
6C47.10
… episodic
6C47.11
… continuous
6C47.1Z
… unspecified
6C47
67
List of categories
6C47.2
Synthetic cathinone dependence
Specify pattern of substance use or remission:
6C47.20
… current use
6C47.21
… early full remission
6C47.22
… sustained partial remission
6C47.23
… sustained full remission
6C47.2Z
… unspecified
6C47.3
Synthetic cathinone intoxication
Specify severity:
6C47.3&XS5W
Synthetic cathinone intoxication, mild
6C47.3&XS0T Synthetic cathinone intoxication, moderate
6C47.3&XS25 Synthetic cathinone intoxication, severe
6C47.4
Synthetic cathinone withdrawal
6C47.5
Synthetic cathinone-induced delirium
6C47.6
Synthetic cathinone-induced psychotic disorder
Specify clinical presentation:
6C47.60
… with hallucinations
6C47.61
… with delusions
6C47.62
… with mixed psychotic symptoms
6C47.6Z
… unspecified
6C47.70
Synthetic cathinone-induced mood disorder
Specify clinical presentation:
6C47.700
… with depressive symptoms
6C47.701
… with manic symptoms
6C47.702
… with mixed depressive and manic symptoms
6C47.70Z
… unspecified
6C47.71
Synthetic cathinone-induced anxiety disorder
6C47.72
Synthetic cathinone-induced obsessive-compulsive or related syndrome
6C47.73
Synthetic cathinone-induced impulse control disorder
6C47.Y
Other specified disorder due to use of synthetic cathinones
6C47.Z
Disorder due to use of synthetic cathinones, unspecified
Disorders due to use of caffeine
6C48.0
Episode of harmful use of caffeine
6C48.1
Harmful pattern of use of caffeine
Specify pattern:
6C48.10
… episodic
6C48.11
… continuous
6C48.1Z
… unspecified
6C48.2
Caffeine intoxication
Specify severity:
6C48.2&XS5W
Caffeine intoxication, mild
6C48.2&XS0T
Caffeine intoxication, moderate
6C48.2&XS25
Caffeine intoxication, severe
6C48
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C48.3
Caffeine withdrawal
6C48.71
Caffeine-induced anxiety disorder
6C48.Y
Other specified disorder due to use of caffeine
6C48.Z
Disorder due to use of caffeine, unspecified
Disorders due to use of hallucinogens
6C49.0
Episode of harmful use of hallucinogens
6C49.1
Harmful pattern of use of hallucinogens
Specify pattern:
6C49.10
… episodic
6C49.11
… continuous
6C49.1Z
… unspecified
6C49.2
Hallucinogen dependence
Specify pattern of substance use or remission:
6C49.20
… current use
6C49.21
… early full remission
6C49.22
… sustained partial remission
6C49.23
… sustained full remission
6C49.2Z
… unspecified
6C49.3
Hallucinogen intoxication
Specify severity:
6C49.3&XS5W
Hallucinogen intoxication, mild
6C49.3&XS0T
Hallucinogen intoxication, moderate
6C49.3&XS25
Hallucinogen intoxication, severe
6C49.4
Hallucinogen-induced delirium
6C49.5
Hallucinogen-induced psychotic disorder
6C49.60
Hallucinogen-induced mood disorder
Specify clinical presentation:
6C49.600
… with depressive symptoms
6C49.601
… with manic symptoms
6C49.602
… with mixed depressive and manic symptoms
6C49.60Z
… unspecified
6C49.61
Hallucinogen-induced anxiety disorder
6C49.Y
Other specified disorder due to use of hallucinogens
6C49.Z
Disorder due to use of hallucinogens, unspecified
Disorders due to use of nicotine
6C4A.0
Episode of harmful use of nicotine
6C4A.1
Harmful pattern of use of nicotine
Specify pattern:
6C4A.10
… episodic
6C4A.11
… continuous
6C4A.1Z
… unspecified
6C4A
6C49
6C4A.2
Nicotine dependence
Specify pattern of substance use or remission:
6C4A.20
… current use
6C4A.21
… early full remission
6C4A.22
… sustained partial remission
6C4A.23
… sustained full remission
6C4A.2Z
… unspecified
6C4A.3
Nicotine intoxication
Specify severity:
6C4A.3&XS5W
Nicotine intoxication, mild
6C4A.3&XS0T
Nicotine intoxication, moderate
6C4A.3&XS25
Nicotine intoxication, severe
6C4A.4
Nicotine withdrawal
6C4A.Y
Other specified disorder due to use of nicotine
6C4A.Z
Disorder due to use of nicotine, unspecified
Disorders due to use of volatile inhalants
6C4B
6C4B.0
Episode of harmful use of volatile inhalants
6C4B.1
Harmful pattern of use of volatile inhalants
Specify pattern:
6C4B.10
… episodic
6C4B.11
… continuous
6C4B.1Z
… unspecified
6C4B.2
Volatile inhalant dependence
Specify pattern of substance use or remission:
6C4B.20
… current use
6C4B.21
… early full remission
6C4B.22
… sustained partial remission
6C4B.23
… sustained full remission
6C4B.2Z
… unspecified
6C4B.3
Volatile inhalant intoxication
Specify severity:
6C4B.3&XS5W
Volatile inhalant intoxication, mild
6C4B.3&XS0T
Volatile inhalant intoxication, moderate
6C4B.3&XS25
Volatile inhalant intoxication, severe
6C4B.4
Volatile inhalant withdrawal
6C4B.5
Volatile inhalant-induced delirium
6C4B.6
Volatile inhalant-induced psychotic disorder
6C4B.70
Volatile inhalant-induced mood disorder
Specify clinical presentation:
6C4B.700
… with depressive symptoms
6C4B.701
… with manic symptoms
6C4B.702
… with mixed depressive and manic symptoms
6C4B.70Z
…unspecified
6C4B.71
Volatile inhalant-induced anxiety disorder
6C4B.Y
Other specified disorder due to use of volatile inhalants
6C4B.Z
Disorder due to use of volatile inhalants, unspecified
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Disorders due to use of MDMA or related drugs, including MDA
6C4C.0
Episode of harmful use of MDMA or related drugs, including MDA
6C4C.1
Harmful pattern of use of MDMA or related drugs, including MDA
Specify pattern:
6C4C.10
… episodic
6C4C.11
… continuous
6C4C.1Z
… unspecified
6C4C.2
MDMA or related drug dependence, including MDA
Specify pattern of substance use or remission:
6C4C.20
… current use
6C4C.21
… early full remission
6C4C.22
… sustained partial remission
6C4C.23
… sustained full remission
6C4C.2Z
… unspecified
6C4C.3
MDMA or related drug intoxication, including MDA
Specify severity:
6C4C.3&XS5W
MDMA or related drug intoxication, including
MDA, mild
6C4C.3&XS0T
MDMA or related drug intoxication, including
MDA, moderate
6C4C.3&XS25
MDMA or related drug intoxication, including
MDA, severe
6C4C.4
MDMA or related drug withdrawal, including MDA
6C4C.5
MDMA or related drug-induced delirium, including MDA
6C4C.6
MDMA or related drug-induced psychotic disorder, including MDA
6C4C.70
MDMA or related drug-induced mood disorder, including MDA
Specify clinical presentation:
6C4C.700
… with depressive symptoms
6C4C.701
… with manic symptoms
6C4C.702
… with mixed depressive and manic symptoms
6C4C.70Z
… unspecified
6C4C.71
MDMA or related drug-induced anxiety disorder, including MDA
6C4C.Y
Other specified disorder due to use of MDMA or related drugs, including
MDA
6C4C.Z
Disorder due to use of MDMA or related drugs, including MDA, unspecified
Disorders due to use of dissociative drugs, including ketamine and
phencyclidine (PCP)
6C4D.0
Episode of harmful use of dissociative drugs, including ketamine and PCP
6C4D.1
Harmful pattern of use of dissociative drugs, including ketamine and PCP
Specify pattern:
6C4D.10
… episodic
6C4D.11
… continuous
6C4D.1Z
… unspecified
6C4C
6C4D
71
List of categories
6C4D.2
Dissociative drug dependence, including ketamine and PCP
Specify pattern of substance use or remission:
6C4D.20
… current use
6C4D.21
… early full remission
6C4D.22
… sustained partial remission
6C4D.23
… sustained full remission
6C4D.2Z
… unspecified
6C4D.3
Dissociative drug intoxication, including ketamine and PCP
Specify severity:
6C4D.3&XS5W
Dissociative drug intoxication, including ketamine
and PCP, mild
6C4D.3&XS0T
Dissociative drug intoxication, including ketamine
and PCP, moderate
6C4D.3&XS25
Dissociative drug intoxication, including ketamine
and PCP, severe
6C4D.4
Dissociative drug-induced delirium, including ketamine and PCP
6C4D.5
Dissociative drug-induced psychotic disorder, including ketamine and PCP
6C4D.60
Dissociative drug-induced mood disorder, including ketamine and PCP
Specify clinical presentation:
6C4D.600
… with depressive symptoms
6C4D.601
… with manic symptoms
6C4D.602
… with mixed depressive and manic symptoms
6C4D.60Z
… unspecified
6C4D.61
Dissociative drug-induced anxiety disorder, including ketamine and PCP
6C4D.Y
Other specified disorder due to use of dissociative drugs, including ketamine
and PCP
6C4D.Z
Disorder due to use of dissociative drugs, including ketamine and PCP,
unspecified
Disorders due to use of other specified psychoactive substances,
including medications
6C4E.0
Episode of harmful use of other specified psychoactive substance, including
medications
6C4E.1
Harmful pattern of use of other specified psychoactive substance, including
medications
Specify pattern:
6C4E.10
… episodic
6C4E.11
… continuous
6C4E.1Z
… unspecified
6C4E.2
Other specified psychoactive substance dependence
Specify pattern of substance use or remission:
6C4E.20
… current use
6C4E.21
… early full remission
6C4E.22
… sustained partial remission
6C4E.23
… sustained full remission
6C4E.2Z
… unspecified
6C4E
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C4E.3
Other specified psychoactive substance intoxication
Specify severity:
6C4E.3&XS5W
Other specified psychoactive substance intoxication,
mild
6C4E.3&XS0T
Other specified psychoactive substance intoxication,
moderate
6C4E.3&XS25
Other specified psychoactive substance intoxication,
severe
6C4E.4
Other specified psychoactive substance withdrawal
Specify clinical presentation:
6C4E.40
… uncomplicated
6C4E.41
… with perceptual disturbances
6C4E.42
… with seizures
6C4E.43
… with perceptual disturbances and seizures
6C4E.4Z
… unspecified
6C4E.5
Delirium induced by other specified psychoactive substance, including
medications
6C4E.6
Psychotic disorder induced by other specified psychoactive substance
6C4E.70
Mood disorder induced by other specified psychoactive substance
Specify clinical presentation:
6C4E.700
… with depressive symptoms
6C4E.701
… with manic symptoms
6C4E.702
… with mixed depressive and manic symptoms
6C4E.70Z
… unspecified
6C4E.71
Anxiety disorder induced by other specified psychoactive substance
6C4E.72
Obsessive-compulsive or related disorder induced by other specified
psychoactive substance
6C4E.73
Impulse control disorder induced by other specified psychoactive substance
6C4E.Y
Other specified disorder due to use of other specified psychoactive substance,
including medications
6C4E.Z
Disorder due to use of other specified psychoactive substance, including
medications, unspecified
Disorders due to use of multiple specified psychoactive substances,
including medications
6C4F.0
Episode of harmful use of multiple specified psychoactive substances,
including medications
6C4F.1
Harmful pattern of use of multiple specified psychoactive substances,
including medications
Specify pattern:
6C4F.10
… episodic
6C4F.11
… continuous
6C4F.1Z
… unspecified
6C4F.2
Multiple specified psychoactive substances dependence
Specify pattern of substance use or remission:
6C4F.20
… current use
6C4F.21
… early full remission
6C4F
73
List of categories
6C4F.22
… sustained partial remission
6C4F.23
… sustained full remission
6C4F.2Z
… unspecified
6C4F.3
Intoxication due to multiple specified psychoactive substances
Specify severity:
6C4F.3&XS5W
Intoxication due to multiple specified psychoactive
substances, mild
6C4F.3&XS0T
Intoxication due to multiple specified psychoactive
substances, moderate
6C4F.3&XS25
Intoxication due to multiple specified psychoactive
substances, severe
6C4F.4
Multiple specified psychoactive substances withdrawal
Specify clinical presentation:
6C4F.40
… uncomplicated
6C4F.41
… with perceptual disturbances
6C4F.42
… with seizures
6C4F.43
… with perceptual disturbances and seizures
6C4F.4Z
… unspecified
6C4F.5
Delirium induced by multiple specified psychoactive substances, including
medications
6C4F.6
Psychotic disorder induced by multiple specified psychoactive substances
6C4F.70
Mood disorder induced by multiple specified psychoactive substances
Specify clinical presentation:
6C4F.700
… with depressive symptoms
6C4F.701
… with manic symptoms
6C4F.702
… with mixed depressive and manic symptoms
6C4F.70Z
… unspecified
6C4F.71
Anxiety disorder induced by multiple specified psychoactive substances
6C4F.72
Obsessive-compulsive or related disorder induced by multiple specified
psychoactive substances
6C4F.73
Impulse control disorder induced by multiple specified psychoactive
substances
6C4F.Y
Other specified disorder due to use of multiple specified psychoactive
substances, including medications
6C4F.Z
Disorder due to use of multiple specified psychoactive substances, including
medications, unspecified
Disorders due to use of unknown or unspecified psychoactive
substances
6C4G.0
Episode of harmful use of unknown or unspecified psychoactive substance
6C4G.1
Harmful pattern of use of unknown or unspecified psychoactive substance
Specify pattern:
6C4G.10
… episodic
6C4G.11
… continuous
6C4G.1Z
… unspecified
6C4G
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C4G.2
Unknown or unspecified psychoactive substance dependence
Specify pattern of substance use or remission:
6C4G.20
… current use
6C4G.21
… early full remission
6C4G.22
… sustained partial remission
6C4G.23
… sustained full remission
6C4G.2Z
… unspecified
6C4G.3
Intoxication due to unknown or unspecified psychoactive substance
Specify severity:
6C4G.3&XS5W
Intoxication due to unknown or unspecified
psychoactive substance, mild
6C4G.3&XS0T
Intoxication due to unknown or unspecified
psychoactive substance, moderate
6C4G.3&XS25
Intoxication due to unknown or unspecified
psychoactive substance, severe
6C4G.4
Withdrawal due to unknown or unspecified psychoactive substance
Specify clinical presentation:
6C4G.40
… uncomplicated
6C4G.41
… with perceptual disturbances
6C4G.42
… with seizures
6C4G.43
… with perceptual disturbances and seizures
6C4G.4Z
… unspecified
6C4G.5
Delirium induced by unknown or unspecified psychoactive substance
6C4G.6
Psychotic disorder induced by unknown or unspecified psychoactive
substance
6C4G.70
Mood disorder induced by unknown or unspecified psychoactive substance
Specify clinical presentation:
6C4G.700
… with depressive symptoms
6C4G.701
… with manic symptoms
6C4G.702
… with mixed depressive and manic symptoms
6C4G.70Z
… unspecified
6C4G.71
Anxiety disorder induced by unknown or unspecified psychoactive
substance
6C4G.72
Obsessive-compulsive or related disorder induced by unknown or
unspecified psychoactive substance
6C4G.73
Impulse control disorder induced by unknown or unspecified psychoactive
substance
6C4G.Y
Other specified disorder due to use of unknown or unspecified psychoactive
substance
6C4G.Z
Disorder due to use of unknown or unspecified psychoactive substance,
unspecified

14 - Disorders due to addictive behaviours
Disorders due to addictive behaviours
Disorders due to use of non-psychoactive substances
6C4H
6C4H.0
Episode of harmful use of non-psychoactive substance
6C4H.1
Harmful pattern of use of non-psychoactive substance
Specify pattern:
6C4H.10
… episodic
6C4H.11
… continuous
6C4H.1Z
… unspecified
6C4H.Z
Disorder due to use of non-psychoactive substances, unspecified
Disorder due to substance use, unspecified
6C4Z
Disorders due to addictive behaviours
Gambling disorder
6C50
Specify context:
6C50.0
… predominantly offline
6C50.1
… predominantly online
6C50.Z
… unspecified
Gaming disorder
6C51
Specify context:
6C51.0
… predominantly online
6C51.1
… predominantly offline
6C51.Z
… unspecified
Other specified disorder due to addictive behaviours
6C5Y
Disorder due to addictive behaviours, unspecified
6C5Z
List of categories

15 - Impulse control disorders
Impulse control disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Impulse control disorders
Pyromania
Kleptomania
Compulsive sexual behaviour disorder
Intermittent explosive disorder
Other specified impulse control disorder
Impulse control disorder, unspecified
Secondary-parented categories
From obsessive-compulsive and related disorders:
Body-focused repetitive behaviour disorders
6B25.0
Trichotillomania (hair-pulling disorder)
6B25.1
Excoriation (skin-picking) disorder
6B25.Y
Other specified body-focused repetitive behaviour disorder
6B25.Z
Body-focused repetitive behaviour disorder, unspecified
From disorders due to addictive behaviours:
Gambling disorder
Specify predominantly online or offline:
6C50.0
… predominantly offline
6C50.1
… predominantly online
6C50.Z
… unspecified
6C72
6C73
6C7Z
6C7Y
6C70
6C71
6B25
6C50
77
List of categories
Gaming disorder
Specify predominantly online or offline:
6C51.0
… predominantly online
6C51.1
… predominantly offline
6C51.Z
… unspecified
From disorders due to substance use:
Substance-induced impulse control disorders
Specify substance class:
6C45.73
Cocaine-induced impulse control disorder
6C46.73
Stimulant-induced impulse control disorder, including amfetamines,
methamfetamine and methcathinone
6C47.73
Synthetic cathinone-induced impulse control disorder
6C4E.73
Impulse control disorder induced by other specified psychoactive substance
6C4F.73
Impulse control disorder induced by multiple specified psychoactive
substances
6C4G.73
Impulse control disorder induced by unknown or unspecified psychoactive
substances
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary impulse control syndrome
6E66
6C51

16 - Disruptive behaviour and dissocial disorders
Disruptive behaviour and dissocial disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6D10
Disruptive behaviour and dissocial disorders
Oppositional defiant disorder
Specify whether chronic irritability-anger is present:
6C90.0
Oppositional defiant disorder, with chronic irritability-anger
Specify limited or typical prosocial emotions:
6C90.00
… with limited prosocial emotions
6C90.01
… with typical prosocial emotions
6C90.0Z
… unspecified
6C90.1
Oppositional defiant disorder, without chronic irritability-anger
Specify limited or typical prosocial emotions:
6C90.10
… with limited prosocial emotions
6C90.11
… with typical prosocial emotions
6C90.1Z
… unspecified
6C90.Z
Oppositional defiant disorder, unspecified
Conduct-dissocial disorder
Specify age of onset:
6C91.0
Conduct-dissocial disorder, childhood onset
Specify limited or typical prosocial emotions:
6C91.00
… childhood onset with limited prosocial emotions
6C91.01
… childhood onset with typical prosocial emotions
6C91.0Z
… childhood onset, unspecified
6C91.1
Conduct-dissocial disorder, adolescent onset
6C91.10
… adolescent onset with limited prosocial emotions
6C91.11
… adolescent onset with typical prosocial emotions
6C91.1Z
… adolescent onset, unspecified
6C91.Z
Conduct-dissocial disorder, unspecified
Other specified disruptive behaviour or dissocial disorder
Disruptive behaviour or dissocial disorder, unspecified
6C90
6C91
6C9Y
6C9Z

17 - Personality disorders and related traits
Personality disorders and related traits
79
List of categories
Postcoordination for personality disorders
For all above personality disorder categories, specify prominent personality traits or
patterns using additional code(s):
6D11.0
Negative affectivity
6D11.1
Detachment
6D11.2
Dissociality
6D11.3
Disinhibition
6D11.4
Anankastia
6D11.5
Borderline pattern
Personality disorders and related traits
Personality disorder
Specify severity:
6D10.0
Mild personality disorder
6D10.1
Moderate personality disorder
6D10.2
Severe personality disorder
6D10.Z
Personality disorder, severity unspecified
Secondary-parented categories
From Chapter 21 on factors influencing health status or contact with
health services
Personality difficulty
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary personality change
6D10
QE50.7
6E68

18 - Paraphilic disorders
Paraphilic disorders

19 - Factitious disorders
Factitious disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Paraphilic disorders
Exhibitionistic disorder
Voyeuristic disorder
Paedophilic disorder
Coercive sexual sadism disorder
Frotteuristic disorder
Other paraphilic disorder involving non-consenting individuals
Paraphilic disorder involving solitary behaviour or consenting
individuals
Paraphilic disorder, unspecified
6D30
6D31
6D33
6D34
6D32
6D36
6D35
6D3Z
Factitious disorders
Factitious disorder imposed on self
Factitious disorder imposed on another
Factitious disorder, unspecified
6D50
6D51
6D5Z

20 - Neurocognitive disorders
Neurocognitive disorders
81
List of categories
Neurocognitive disorders
Delirium
Specify identified cause:
6D70.0
Delirium due to disease classified elsewhere
6D70.1
Delirium due to psychoactive substances, including medications
Specify substance class:
(Note: the categories below are from the disorders due to substance use
grouping.)
6C40.5
Alcohol-induced delirium
6C41.5
Cannabis-induced delirium
6C42.5
Synthetic cannabinoid-induced delirium
6C43.5
Opioid-induced delirium
6C44.5
Sedative, hypnotic or anxiolytic-induced delirium
6C45.5
Cocaine-induced delirium
6C46.5
Stimulant-induced delirium, including amfetamines,
methamfetamine and methcathinone
6C47.5
Synthetic cathinone-induced delirium
6C49.4
Hallucinogen-induced delirium
6C4B.5
Volatile inhalant-induced delirium
6C4C.5
MDMA or related drug-induced delirium, including MDA
6C4D.4
Dissociative drug-induced delirium, including ketamine and
PCP
6C4E.5
Delirium induced by other specified psychoactive substance,
including medications
6C4F.5
Delirium induced by multiple specified psychoactive
substances, including medications
6C4G.5
Delirium induced by unknown or unspecified psychoactive
substances
6D70.2
Delirium due to multiple etiological factors
6D70.Y
Delirium, other specified cause
6D70.Z
Delirium, unknown or unspecified cause
Mild neurocognitive disorder
Amnestic disorder
Specify identified cause:
6D72.0
Amnestic disorder due to diseases classified elsewhere
6D72.1
Amnestic disorder due to psychoactive substances, including medications
Specify substance class:
6D72.10
Amnestic disorder due to use of alcohol
6D72.11
Amnestic disorder due to use of sedatives, hypnotics or
anxiolytics
6D71
6D72
6D70
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6D72.12
Amnestic disorder due to other specific psychoactive
substance, including medications
6D72.13
Amnestic disorder due to use of volatile inhalants
6D72.Y
Amnestic disorder, other specified cause
6D72.Z
Amnestic disorder, unknown or unspecified cause
Dementia
Specify identified causal condition:
Dementia due to Alzheimer disease
Specify subtype of Alzheimer disease:
6D80.0
… with early onset
6D80.1
… with late onset
6D80.2
… mixed type, with cerebrovascular disease
6D80.3
… mixed type, with other nonvascular etiologies
6D80.Z
… onset unknown or unspecified
Dementia due to cerebrovascular disease
Dementia due to Lewy body disease
Frontotemporal dementia
Dementia due to psychoactive substances, including medications
Specify substance class:
6D84.0
Dementia due to use of alcohol
6D84.1
Dementia due to use of sedatives, hypnotics or anxiolytics
6D84.2
Dementia due to use of volatile inhalants
6D84.Y
Dementia due to other specified psychoactive substance
6D80
6D81
6D82
6D83
6D84
Dementia due to diseases classified elsewhere
6D85
Specify identified causal condition:
6D85.0
Dementia due to Parkinson disease
6D85.1
Dementia due to Huntington disease
6D85.2
Dementia due to exposure to heavy metals and other toxins
6D85.3
Dementia due to HIV
6D85.4
Dementia due to multiple sclerosis
6D85.5
Dementia due to prion disease
6D85.6
Dementia due to normal-pressure hydrocephalus
6D85.7
Dementia due to injury to the head
6D85.8
Dementia due to pellagra
6D85.9
Dementia due to Down syndrome
6D85.Y
Dementia due to other specified disease classified elsewhere
Dementia, other specified cause
6D8Y
Dementia, unknown or unspecified cause
6D8Z
Postcoordination for dementia:
List of categories
For all above dementia categories, specify severity of dementia by using additional
code:
XS5W
Mild
XS0T
Moderate
XS25
Severe
For all above dementia categories, specify behavioural or psychological disturbances
in dementia by using additional code(s) if applicable:
6D86.0
Psychotic symptoms in dementia
6D86.1
Mood symptoms in dementia
6D86.2
Anxiety symptoms in dementia
6D86.3
Apathy in dementia
6D86.4
Agitation or aggression in dementia
6D86.5
Disinhibition in dementia
6D86.6
Wandering in dementia
6D86.Y
Other specified behavioural or psychological disturbance in
dementia
6D86.Z
Behavioural or psychological disturbances in dementia,
unspecified

21 - Mental and behavioural disorders associated w
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium

22 - Psychological or behavioural factors affectin
Psychological or behavioural factors  affecting disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Other specified neurocognitive disorder
Neurocognitive disorder, unspecified
Secondary-parented category
From secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere:
Secondary neurocognitive syndrome
6E0Y
6E0Z
6E67
Mental and behavioural disorders associated with
pregnancy, childbirth or the puerperium
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, without psychotic symptoms
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, with psychotic symptoms
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, unspecified
6E20
6E21
6E2Z
Psychological or behavioural factors
affecting disorders and diseases classified elsewhere
Mental disorder affecting disorders and diseases classified elsewhere
6E40.0

23 - Secondary mental or behavioural syndromes ass
Secondary mental or behavioural syndromes associated  with disorders and diseases classified elsewhe
85
List of categories
Psychological symptoms affecting disorders and diseases classified
elsewhere
Personality traits or coping style affecting disorders and diseases
classified elsewhere
Maladaptive health behaviours affecting disorders and diseases
classified elsewhere
Stress-related physiological response affecting disorders and
diseases classified elsewhere
Other specified psychological or behavioural factor affecting
disorders and diseases classified elsewhere
Psychological or behavioural factors affecting disorders and diseases
classified elsewhere, unspecified
Secondary mental or behavioural syndromes associated
with disorders and diseases classified elsewhere
Secondary neurodevelopmental syndrome
6E60.0
Secondary speech or language syndrome
6E60.Y
Other specified secondary neurodevelopmental syndrome
6E60.Z
Secondary neurodevelopmental syndrome, unspecified
Secondary psychotic syndrome
Specify clinical presentation:
6E61.0
… with hallucinations
6E61.1
… with delusions
6E61.2
… with hallucinations and delusions
6E61.3
… with unspecified symptoms
6E40.1
6E40.2
6E40.3
6E40.4
6E40.Y
6E40.Z
6E60
6E61
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Secondary mood syndrome
Specify clinical presentation:
6E62.0
… with depressive symptoms
6E62.1
… with manic symptoms
6E62.2
… with mixed symptoms
6E62.3
… with unspecified symptoms
Secondary anxiety syndrome
Secondary obsessive-compulsive or related syndrome
Secondary dissociative syndrome
Secondary impulse control syndrome
Secondary neurocognitive syndrome
Secondary personality change
Secondary catatonia syndrome
Other specified secondary mental or behavioural syndrome
Secondary mental or behavioural syndrome, unspecified
6E62
6E63
6E64
6E65
6E66
6E69
6E67
6E68
6E6Y
6E6Z
87
List of categories
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

06 - Mental, behavioural and neurodevelopmental disorde

01 - Neurodevelopmental disorders
Neurodevelopmental disorders
91
Neurodevelopmental disorders
6A01
Neurodevelopmental disorders include the following:
6A00
Disorders of intellectual development
Developmental speech and language disorders
6A01.0 Developmental speech sound disorder
6A01.1 Developmental speech fluency disorder
6A01.2 Developmental language disorder
6A01.Y Other specified developmental speech or language disorder
6A01.Z Developmental speech or language disorder, unspecified
Neurodevelopmental disorders
Neurodevelopmental disorders are behavioural and cognitive disorders arising during the
developmental period that involve significant difficulties in the acquisition and execution
of specific intellectual, motor, language or social functions. In this context, arising during the
developmental period is typically considered to mean that these disorders have their onset prior
to 18 years of age, regardless of the age at which the individual first comes to clinical attention.
Although behavioural and cognitive deficits are present in many mental and behavioural
disorders that can arise during the developmental period (e.g. schizophrenia, bipolar disorder),
only disorders whose core features are neurodevelopmental are included in this grouping.
The presumptive etiology for neurodevelopmental disorders is complex, and in many individual
cases is unknown, but they are presumed to be primarily due to genetic or other factors that are
present from birth. However, lack of appropriate environmental stimulation and lack of adequate
learning opportunities and experiences may also be contributory factors in neurodevelopmental
disorders and should be considered routinely in their assessment. Certain neurodevelopmental
disorders may also arise from injury, disease or other insult to the central nervous system, when
this occurs during the developmental period.
6A04
Developmental motor coordination disorder
6A05
Attention deficit hyperactivity disorder
6A06
Stereotyped movement disorder
6A0Y
Other specified neurodevelopmental disorder
6A0Z
Neurodevelopmental disorder, unspecified.
6A02
Autism spectrum disorder
6A03
Developmental learning disorder
Neurodevelopmental disorders

02 - 6A00 Disorders of intellectual development
6A00 Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
In addition, three categories from the grouping of primary tics and tic disorders in Chapter 8 on
diseases of the nervous system are cross-listed here, with diagnostic guidance provided, because
of their high co-occurrence and familial association with neurodevelopmental disorders.
These include:
8A05.00
Tourette syndrome
8A05.01
Chronic motor tic disorder
8A05.02
Chronic phonic tic disorder
General cultural considerations for neurodevelopmental disorders
• The evaluation of the essential features of most of the disorders in this section either
depends on or is informed by standardized assessments. The cultural appropriateness of
tests and norms used to assess intellectual, motor, language or social abilities should be
considered for each individual. Test performance may be affected by cultural biases (e.g.
reference in test items to terminology or objects not common to a culture) and limitations
of translation. Language proficiency must also be considered when interpreting test results.
Where appropriately normed and standardized tests are not available, assessment of the
essential features of these disorders requires greater reliance on clinical judgement based
on appropriate evidence and assessment.
Disorders of intellectual development
Essential (required) features
• The presence of significant limitations in intellectual functioning across various domains
such as perceptual reasoning, working memory, processing speed and verbal comprehension
is required for diagnosis. There is often substantial variability in the extent to which any
of these domains are affected in an individual. Whenever possible, performance should be
measured using appropriately normed, standardized tests of intellectual functioning and
found to be approximately 2 or more standard deviations below the mean (i.e. approximately
less than the 2.3rd percentile). In situations where appropriately normed and standardized
tests are not available, assessment of intellectual functioning requires greater reliance on
clinical judgement based on appropriate evidence and assessment, which may include the
use of behavioural indicators of intellectual functioning (see Table 6.1, p. 101).
• The presence of significant limitations in adaptive behaviour, which refers to the set of
conceptual, social and practical skills that have been learned and are performed by people in
their everyday lives, is an essential component. Conceptual skills are those that involve the
application of knowledge (e.g. reading, writing, calculating, solving problems and making
decisions) and communication; social skills include managing interpersonal interactions
6A00
Neurodevelopmental disorders | Disorders of intellectual development
93
Neurodevelopmental disorders
and relationships, social responsibility, following rules and obeying laws, and avoiding
victimization; and practical skills are involved in areas such as self-care, health and safety,
occupational skills, recreation, use of money, mobility and transportation, as well as use
of home appliances and technological devices. Expectations of adaptive functioning
may change in response to environmental demands that change with age. Whenever
possible, performance should be measured with appropriately normed, standardized tests
of adaptive behaviour and the total score found to be approximately 2 or more standard
deviations below the mean (i.e. approximately less than the 2.3rd percentile). In situations
where appropriately normed and standardized tests are not available, assessment of
adaptive behaviour functioning requires greater reliance on clinical judgement based on
appropriate assessment, which may include the use of behavioural indicators of adaptive
behaviour skills (see Tables 6.2–6.4, pp. 104–111).
• Onset occurs during the developmental period. Among adults with disorders of intellectual
development who come to clinical attention without a previous diagnosis, it is possible to
establish developmental onset through the person’s history (retrospective diagnosis).
Severity specifiers
The severity of a disorder of intellectual development is determined by considering both the
individual’s level of intellectual ability and level of adaptive behaviour, ideally assessed using
appropriately normed, individually administered standardized tests. Where appropriately
normed and standardized tests are not available, assessment of intellectual functioning and
adaptive behaviour requires greater reliance on clinical judgement based on appropriate evidence
and assessment, which may include the use of behavioural indicators of intellectual and adaptive
functioning provided in Tables 6.1–6.4.
Generally, the level of severity should be assigned on the basis of the level at which the majority
of the individual’s intellectual ability and adaptive behaviour skills across all three domains –
conceptual, social and practical skills – fall. For example, if intellectual functioning and two of
three adaptive behaviour domains are determined to be 3–4 standard deviations below the mean,
moderate disorder of intellectual development would be the most appropriate diagnosis. However,
this formulation may vary according to the nature and purpose of the assessment, as well as the
importance of the behaviour in question in relation to the individual’s overall functioning.
Disorder of intellectual development, mild
• In mild disorder of intellectual development, intellectual functioning and adaptive behaviour
are found to be approximately 2–3 standard deviations below the mean (approximately
0.1–2.3 percentile), based on appropriately normed, individually administered standardized
tests. Where standardized tests are not available, assessment of intellectual functioning and
adaptive behaviour requires greater reliance on clinical judgement, which may include
the use of behavioural indicators provided in Tables 6.1–6.4. People with mild disorder of
intellectual development often exhibit difficulties in the acquisition and comprehension of
complex language concepts and academic skills. Most master basic self-care, domestic and
practical activities. Affected people can generally achieve relatively independent living and
employment as adults, but may require appropriate support.
6A00.0
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Disorder of intellectual development, moderate
• In moderate disorder of intellectual development, intellectual functioning and adaptive
behaviour are found to be approximately 3–4 standard deviations below the mean
(approximately 0.003–0.1 percentile), based on appropriately normed, individually
administered standardized tests. Where standardized tests are not available, assessment
of intellectual functioning and adaptive behaviour requires greater reliance on clinical
judgement, which may include the use of behavioural indicators provided in Tables
6.1–6.4. Language and capacity for acquisition of academic skills of people affected by
moderate disorder of intellectual development vary but are generally limited to basic skills.
Some may master basic self-care, domestic and practical activities. Most affected people
require considerable and consistent support in order to achieve independent living and
employment as adults.
Disorder of intellectual development, severe
• In severe disorder of intellectual development, intellectual functioning and adaptive
behaviour are found to be approximately 4 or more standard deviations below the
mean (less than approximately the 0.003rd percentile), based on appropriately normed,
individually administered standardized tests. Where standardized tests are not available,
assessment of intellectual functioning and adaptive behaviour requires greater reliance
on clinical judgement, which may include the use of behavioural indicators provided
in Tables 6.1–6.4. People affected by severe disorder of intellectual development exhibit
very limited language and capacity for acquisition of academic skills. They may also have
motor impairments and typically require daily support in a supervised environment for
adequate care, but may acquire basic self-care skills with intensive training. Severe and
profound disorders of intellectual development are differentiated exclusively on the basis
of adaptive behaviour differences because existing standardized tests of intelligence cannot
reliably or validly distinguish among individuals with intellectual functioning below the
0.003rd percentile.
Disorder of intellectual development, profound
• In profound disorder of intellectual development, intellectual functioning and adaptive
behaviour are found to be approximately 4 or more standard deviations below the mean
(approximately less than the 0.003rd percentile), based on individually administered
appropriately normed, standardized tests. Where standardized tests are not available,
assessment of intellectual functioning and adaptive behaviour requires greater reliance on
clinical judgement, which may include the use of behavioural indicators provided in Tables
6.1–6.4. People affected by profound disorder of intellectual development possess very
limited communication abilities and capacity for acquisition of academic skills is restricted
to basic concrete skills. They may also have co-occurring motor and sensory impairments
and typically require daily support in a supervised environment for adequate care. Severe
and profound disorders of intellectual development are differentiated exclusively on the
basis of adaptive behaviour differences because existing standardized tests of intelligence
cannot reliably or validly distinguish among individuals with intellectual functioning
below the 0.003rd percentile.
6A00.1
6A00.2
6A00.3
Neurodevelopmental disorders | Disorders of intellectual development
95
Neurodevelopmental disorders
Disorder of intellectual development, provisional
• Provisional disorder of intellectual development is assigned when there is evidence of a
disorder of intellectual development but the individual is an infant or child under the age
of 4 years, making it difficult to ascertain whether the observed impairments represent
a transient delay. Provisional disorder of intellectual development in this context is
sometimes referred to as “global developmental delay”. The diagnosis can also be assigned
in individuals 4 years of age or older when evidence is suggestive of a disorder of intellectual
development but it is not possible to conduct a valid assessment of intellectual functioning
and adaptive behaviour because of sensory or physical impairments (e.g. blindness, prelingual deafness), motor or communication impairments, severe problem behaviours, or
symptoms of another mental, behavioural or neurodevelopmental disorder that interfere
with assessment.
Disorder of intellectual development, unspecified
Additional clinical features
• No single physical feature or personality type is common to all individuals with disorders
of intellectual development, although specific etiological groups may have common
physical characteristics.
• Disorders of intellectual development are associated with a high rate of co-occurring
mental, behavioural and neurodevelopmental disorders. However, clinical presentations
may vary depending on the individual’s age, level of severity of the disorder of intellectual
development, communication skills and symptom complexity. Some disorders – such
as autism spectrum disorder, depressive disorders, bipolar and related disorders,
schizophrenia, dementia and attention deficit hyperactivity disorder – occur more
commonly among individuals with disorders of intellectual development than in the
general population. Individuals with a co-occurring disorder of intellectual development
and other mental, behavioural and neurodevelopmental disorders are at similar risk of
suicide as individuals with mental disorders who do not have a co-occurring disorder of
intellectual development.
• Problem or challenging behaviours such as aggression, self-injurious behaviour, attentionseeking behaviour, oppositional defiant behaviour and sexually inappropriate behaviour
are more frequent among those with disorders of intellectual development than in the
general population.
• Many individuals with disorders of intellectual development are more gullible and naive,
easier to deceive, and more prone to acquiescence and confabulation than people in the
general population. This can lead to various consequences, including greater likelihood
of victimization, becoming involved in criminal activities and providing inaccurate
statements to law enforcement.
• Significant life changes and traumatic experiences can be particularly difficult for a person
with a disorder of intellectual development. Whereas the timing and type of life transitions
vary across societies, it is generally the case that individuals with disorders of intellectual
6A00.4
6A00.Z
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
development need additional support adapting to changes in routine, structure, or
educational or living arrangements.
• Many medical conditions can cause disorders of intellectual development and are, in turn,
associated with specific additional medical problems. A variety of prenatal (e.g. exposure
to toxic substances or harmful medications), perinatal (e.g. labour and delivery problems)
and postnatal (e.g. infectious encephalopathies) factors may contribute to the development
of disorders of intellectual development, and multiple etiologies may interact. Early
diagnosis of the etiology of a disorder of intellectual development, when possible, can
assist in the prevention and management of related medical problems (e.g. frequent thyroid
disease screening is recommended for individuals with Down syndrome). If the etiology of
a disorder of intellectual development in a particular individual has been established, the
diagnosis corresponding to that etiology should also be assigned.
• Individuals with disorders of intellectual development are at greater risk of a variety of
health (e.g. epilepsy) and social (e.g. poverty) problems across the lifespan.
Boundary with normality (threshold)
• In disorders of intellectual development, a measure of intelligence quotient (IQ) is not
an isolated diagnostic requirement to distinguish disorder from normality, but should be
considered a proxy measure of the “significant limitations in intellectual functioning” that
partially characterize disorders of intellectual development. IQ scores may vary as a result
of the technical properties of the specific test being used, the testing conditions and a
variety of other variables, and also can vary substantially over the individual’s development
and life-course. The diagnosis of disorders of intellectual development should not be
made solely based on IQ scores but must also include a comprehensive evaluation of
adaptive behaviour.
• Scores on individually administered standardized tests of intellectual and adaptive
functioning may vary considerably over the course of an individual’s development, and it
is quite possible that, during the developmental period, a child may meet the diagnostic
requirements of disorders of intellectual development on one occasion but not another.
Multiple testing on different occasions during the developmental trajectory is necessary to
establish a reliable estimate of functioning.
• Special care should be taken in differentiating disorders of intellectual development
from normality when evaluating people with communication, sensory or motor
impairments; those exhibiting behavioural disturbances; immigrants; people with low
literacy levels; people with mental disorders; people undergoing medical treatments
(e.g. pharmacotherapy); and people who have experienced severe social or sensory
deprivation. If not adequately addressed during the evaluation, these factors may reduce
the validity of scores obtained on standardized or behavioural measures of intellectual and
adaptive functioning. For example, the reliable use of standardized measures of intellectual
functioning and adaptive behaviour may pose particular challenges among individuals
with motor coordination and communication impairments, and assessments must be
selected that are appropriate to the individual’s capacities.
• What is sometimes termed “borderline intellectual functioning”, defined as intellectual
functioning between approximately 1 and 2 standard deviations below the mean, is not a
diagnosable disorder. Nonetheless, such individuals may present many needs for support and
interventions that are similar to those of people with disorders of intellectual development.
Neurodevelopmental disorders | Disorders of intellectual development
97
Neurodevelopmental disorders
Course features
• Disorders of intellectual development are lifespan conditions that typically manifest during
early childhood and require consideration of developmental phases and life transitions
whereby periods of relatively greater need may alternate with those where less support
may be necessary.
• Disorders of intellectual development may show individual as well as etiology-specific
variation in developmental trajectories (i.e. periods of relative decline or amelioration in
functioning). Intellectual functioning and adaptive behaviour can vary substantially across
the lifespan. Results from a single assessment, particularly those obtained during early
childhood, may be of limited predictive use, as later functioning will be influenced by the
level and type of interventions and support provided.
• People with disorders of intellectual development typically need exceptional support
throughout the lifespan, although the types and intensities of required support often change
over time depending on age, development, environmental factors and life circumstances.
Most people with disorders of intellectual development continue to acquire skills and
competencies over time. Providing interventions and support – including education –
assists with this process and, if provided during the developmental period, may result in
lower support needs in adulthood.
Developmental presentations
• There is wide variability in the developmental presentation and developmental trajectories
of individuals with disorders of intellectual development. Tables 6.2–6.4 provide clinicians
with some of the key areas of strengths and weaknesses typically observed at different time
points across development (i.e. early childhood, childhood, adolescence and adulthood) in
individuals with disorders of intellectual development.
• Conditions related to disorders of intellectual development may be suspected during the
first days and months of life due to the presence of certain physical signs such as facial
dimorphisms, congenital malformation, micro- or macrocephalia, low weight, hypotonia,
physical growth retardation, metabolic problems and failure to thrive, among others.
• In older children, disorders of intellectual development may manifest as problems in
acquiring academic knowledge and abilities such as reading, writing and arithmetic. Many
children with mild disorder of intellectual development may not be referred for evaluation
until they reach school age. Some individuals may remain undiagnosed until much later,
during adolescence or adulthood.
• The manifestations of disorders of intellectual development during late adolescence and the
first years of adulthood may be strongly influenced by the presence of challenges related to
assuming adult roles, such as postsecondary education, employment, independent living
and adult relationships.
• Older adults with disorders of intellectual development may present with a more rapid
onset of dementia or declining skills than older adults in the general population. They
also have significantly more difficulty gaining access to necessary support and appropriate
health care for medical problems.
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Culture-related features
• The cultural appropriateness of tests and norms used to assess intellectual and adaptive
functioning should be considered for each individual. Test performance may be affected
by cultural biases (e.g. reference in test items to terminology or objects not common to a
culture) and limitations of translation.
• In evaluating adaptive functioning (i.e. the individual’s conceptual, social and practical
skills), the expectations of the individual’s culture and social environment should be
considered.
• Language proficiency must also be considered when interpreting test results, in terms
of both its impact on verbal performance and whether the individual understood
the instructions.
Sex- and/or gender-related features
• The overall prevalence of disorders of intellectual development is slightly higher in
males. The prevalence of some etiologies of disorders of intellectual development differs
between males and females (e.g. X-linked genetic conditions such as fragile X syndrome
are predominantly diagnosed in males, whereas Turner syndrome occurs exclusively in
females).
• A number of associated features of disorders of intellectual development differ between
males and females – for example, in the expression of problem behaviours and co-occurring
mental, behavioural and neurodevelopmental disorders. Males are more likely to exhibit
hyperactivity and conduct disturbances, whereas females are more likely to exhibit mood
and anxiety symptoms.
• Reduced social value and expectations placed on females compared to males in some
societies may negatively affect the accurate identification and provision of support for
females with disorders of intellectual development.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with developmental speech and language disorders
In developmental speech and language disorders, individuals exhibit difficulties in understanding or
producing speech and language, or in using language in context for the purposes of communication
that is markedly below what would be expected given the individual’s age and level of intellectual
functioning. If speech and language abilities are significantly below what would be expected based
on intellectual and adaptive behaviour functioning in an individual with a disorder of intellectual
development, an additional diagnosis of developmental speech and language disorder may
be assigned.
Neurodevelopmental disorders | Disorders of intellectual development
99
Neurodevelopmental disorders
Boundary with autism spectrum disorder
Autism spectrum disorder is characterized by persistent deficits in reciprocal social interaction and
social communication, and by a range of restricted, repetitive, inflexible patterns of behaviour and
interests. Although many individuals with autism spectrum disorder present with the significant
limitations in intellectual functioning and adaptive behaviour observed in disorders of intellectual
development, autism spectrum disorder can also present without general limitations in intellectual
functioning. In cases of autism spectrum disorder where there are significant limitations in
intellectual functioning and adaptive behaviour (i.e. 2 or more standard deviations below the mean
or approximately less than the 2.3rd percentile) both the diagnosis of autism spectrum disorder
using the with disorder of intellectual development specifier and the diagnosis of a disorder of
intellectual development at the corresponding level of severity should be assigned. The diagnosis
of autism spectrum disorder in individuals with severe and profound disorders of intellectual
development is particularly difficult, and requires in-depth and longitudinal assessments. Because
autism spectrum disorder inherently involves social deficits, assessment of adaptive behaviour as
a part of the diagnosis of a co-occurring disorder of intellectual development should place greater
emphasis on the conceptual and practical domains of adaptive functioning than on social skills.
Boundary with developmental learning disorders
Developmental learning disorders are characterized by significant and persistent difficulties in
learning academic skills including reading, writing and arithmetic, with performance in these areas
markedly below what would be expected based on chronological age or intellectual level. Individuals
with disorders of intellectual development often present with limitations in academic achievement
by virtue of significant generalized deficits in intellectual functioning. It is therefore difficult to
establish the co-occurring presence of a developmental learning disorder in individuals with a
disorder of intellectual development. However, developmental learning disorders can co-occur
in some individuals with disorders of intellectual development if, despite adequate opportunities,
acquisition of learning is significantly below what is expected based on established intellectual
functioning. In such cases, both disorders may be diagnosed.
Boundary with developmental motor coordination disorders
In developmental motor coordination disorder, individuals exhibit significant delays during the
developmental period in the acquisition of gross and fine motor skills, and impairment in the
execution of coordinated motor skills that manifest in clumsiness, slowness or inaccuracy of motor
performance. Individuals with disorders of intellectual development may also display such motor
coordination difficulties that affect adaptive behaviour functioning. In contrast to those with
developmental motor coordination disorder, individuals with disorders of intellectual development
have accompanying significant limitations in intellectual functioning. However, if coordinated
motor skills are significantly below what would be expected based on level of intellectual functioning
and adaptive behaviour, and represent a separate focus of clinical attention, both diagnoses may
be assigned.
Boundary with attention deficit hyperactivity disorder
In attention deficit hyperactivity disorder, individuals show a persistent and generalized pattern
of inattention and/or hyperactivity-impulsivity that emerges during the developmental period.
If all diagnostic requirements for a disorder of intellectual development are met, and inattention
and/or hyperactivity-impulsivity are found to be outside normal expected limits based on age and
level of intellectual functioning, with significant interference in academic, occupational or social
functioning, both diagnoses may be assigned.
Boundary with dementia
In dementia, affected individuals – usually older adults – exhibit a decline from a previous level
of functioning in multiple cognitive domains that interferes significantly with performance of
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
activities of daily living. The disorders can co-occur, and some adults with disorders of intellectual
development are at greater and earlier risk of developing dementia. For example, individuals
with Down syndrome who exhibit a marked decline in adaptive behaviour functioning should be
evaluated for the emergence of dementia. In cases in which the diagnostic requirements for both a
disorder of intellectual development and dementia are met and describe non-redundant aspects of
the clinical presentation, both diagnoses may be assigned.
Boundary with other mental and behavioural disorders
Other mental and behavioural disorders such as schizophrenia and other primary psychotic
disorders may include symptoms that interfere with intellectual functioning and adaptive behaviour.
A disorder of intellectual development should not be diagnosed if the limitations are better accounted
for by another mental and behavioural disorder. However, other mental and behavioural disorders
are at least as prevalent in individuals with disorders of intellectual development as in the general
population, and co-occurring diagnoses should be assigned if warranted. In evaluating mental and
behavioural disorders in individuals with disorders of intellectual development, signs and symptoms
must be assessed using methods that are appropriate to the individual’s level of development and
intellectual functioning, and may require a greater reliance on observable signs and the reports of
others who are familiar with the individual.
Boundary with sensory impairments
If not addressed, sensory impairments (e.g. visual, auditory) can interfere with opportunities for
learning, resulting in apparent limitations in intellectual functioning or adaptive behaviour. If the
observed limitations are solely attributable to a sensory impairment, a disorder of intellectual
development should not be assigned. However, prolonged sensory impairment throughout the
critical period of development may result in the persistence of limitations in intellectual functioning
or adaptive behaviour, despite later intervention, and an additional diagnosis of a disorder of
intellectual development may be warranted in such cases.
Boundary with effects of psychosocial deprivation
Extreme psychosocial deprivation in early childhood can produce severe and selective impairments
in specific mental functions such as language, social interaction and emotional expression.
Depending on the onset, level of severity and duration of the deprivation, functioning in these
areas may improve substantially after the child is moved to a more positive environment. However,
some deficits may persist even after a sustained period in an environment that provides adequate
stimulation for development, and a diagnosis of a disorder of intellectual development may be
appropriate in such cases if all diagnostic requirements are met.
Boundary with neurodegenerative diseases
Neurodegenerative diseases can be associated with disorders of intellectual development but only
if they have their onset in the developmental period (e.g. mucolipidosis type I, Gaucher’s disease
type III). If a neurodegenerative disease co-occurs with a disorder of intellectual development, both
diagnoses should be assigned.
Boundary with secondary neurodevelopmental syndrome
If the diagnostic requirements of a disorder of intellectual development are met and the symptoms
are attributed to medical conditions with onset during the prenatal or developmental period, both
disorder of intellectual development and the underlying medical conditions should be diagnosed.
If the diagnostic requirements of a disorder of intellectual development are not met (e.g. limitations
in intellectual functioning without limitations in adaptive functioning) and the symptoms are
attributed to medical conditions with onset during the prenatal or developmental period, a diagnosis
of secondary neurodevelopmental syndrome should be assigned, together with the diagnosis
corresponding to the underlying medical condition.
Neurodevelopmental disorders | Disorders of intellectual development
101
Neurodevelopmental disorders | Disorders of intellectual development
Table 6.1. Behavioural indicators of intellectual functioning
Severity level
Early childhood
Childhood and adolescence
Adulthood
Mild
By the end of this developmental
period, there is evidence of
the emergence or presence of
the abilities listed below.
• Most will develop language skills
and be able to communicate
needs. Delays in the acquisition
of language skills are typical,
and once acquired the skills are
frequently less developed than
in typically developing peers
(e.g. more limited vocabulary).
• Most can tell or identify
their gender and age.
• Most can attend to a simple
cause-effect relationship.
• Most can attend to and follow
up to 2-step instructions.
• Most can make one-to-one
correspondence or match
to sample (e.g. organize
or match items according
to shape, size, colour).
• Most can communicate their
immediate future goals (e.g.
desired activities for the day).
• Most can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress.
Literacy/numeracy
• Most will develop emergent
reading and writing skills.
• Most will be able to recognize
letters from their name,
and some can recognize
their own name in print.
During this developmental
period, there is evidence of
the emergence or presence of
the abilities listed below.
• Most can communicate effectively.
• Most can tell or identify their age.
• Most can initiate/invite others
to participate in an activity.
• Most can communicate about
past, present and future events.
• Most can attend to and follow
up to 3-step instructions.
• Most can identify different
denominations of money
(e.g. coins) and count small
amounts of money.
• Most can cross street intersections
safely (look in both directions,
wait for traffic to clear before
crossing, obey traffic signals).
In contexts without busy
intersections, most can follow
socially acceptable rules necessary
to ensure personal safety.
• Most can communicate their
future goals and participate
in their health care.
• Most can identify many of their
relatives and their relationships.
• Most can apply existing abilities
in order to build skills for future
semi-skilled employment (i.e.
involving the performance of
routine operations) and in some
cases skilled employment (e.g.
requiring some independent
judgement and responsibility).
• Most are naive in anticipating
full consequences of actions
or recognizing when someone
is trying to exploit them.
• Some can orient themselves
in the community and travel
to new places using familiar
modes of transportation.
Literacy/numeracy
• Most can read sentences
with five common words.
• Most can count and make simple
additions and subtractions.
Neurodevelopmental disorders
• Most can communicate fluently.
• Many can tell or identify
their birth date.
• Most can initiate/invite others
to participate in an activity.
• Most can communicate about
past, present and future events.
• Most can attend to and follow
up to 3-step instructions.
• Most can identify different
denominations of money
(e.g. coins) and count money
more or less accurately.
• Most can orient themselves
in the community and learn
to travel to new places using
different modes of transportation
with instruction/training.
• Some can learn the road laws
and meet requirements to obtain
a driver’s license. Travel is mainly
restricted to familiar environments.
• Most can cross residential street
intersections safely (look in both
directions, wait for traffic to clear
before crossing, obey traffic
signals). In contexts without busy
intersections, most can follow
socially acceptable rules necessary
to ensure personal safety.
• Most can communicate their
decisions about their future goals,
health care and relationships (e.g.
who they prefer to spend time with).
• Most can apply existing abilities in the
context of semi-skilled employment
(i.e. involving the performance
of routine operations) and in
some cases skilled employment
(e.g. requiring some independent
judgement and responsibility).
• Most remain naive in anticipating
full consequences of actions
or recognizing when someone
is trying to exploit them.
• Most have difficulty in handling
complex situations such as
managing bank accounts and
long-term money management.
Literacy/numeracy
• Most can read and write up to
approximately a level expected
for someone who has attended
7–8 years of schooling (i.e. start
of middle/secondary school),
and read simple material for
information and entertainment.
• Most can count, understand
mathematical concepts and make
simple mathematical calculations.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.1. contd
Severity level
Early childhood
Childhood and adolescence
Adulthood
Moderate
• Most will develop language skills
and be able to communicate
needs. Delays in the acquisition
of language skills are typical,
and once acquired the skills
are often less developed than
in typically developing peers
(e.g. more limited vocabulary).
• Most can follow 1-step instructions.
• Most can self-initiate activities and
participate in parallel play. Some
develop simple interactive play.
• Some can attend to a simple
cause-effect relationship.
• Most can distinguish between
“more” and “less”.
• Some can make one-to-one
correspondence or match
to sample (e.g. organize
or match items according
to shape, size, colour).
• Many can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress.
Literacy/numeracy
• Most can recognize symbols.
• Most can tell or identify
their age and gender.
• Most can initiate/invite others
to participate in an activity.
• Most can communicate
immediate experiences.
• Most can attend to and follow
up to 2-step instructions.
• Some can cross residential street
intersections safely (look in both
directions, wait for traffic to clear
before crossing, obey lights and
signal signals). In contexts without
busy intersections, some can follow
socially acceptable rules necessary
to ensure personal safety.
• Some can go independently
to nearby familiar places.
• Most can communicate
preferences about their future
goals when provided with options.
• Most can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress.
• With support, most can apply
existing abilities in order to build
skills for future semi-skilled
employment (i.e. involving the
performance of routine operations).
• Most are naive in anticipating
full consequences of actions
or recognizing when someone
is trying to exploit them.
Literacy/numeracy
• Most will develop emergent
reading and writing skills.
• Most can recognize their
own name in print.
• Most can choose the correct
number of objects.
• Some can learn to count up to 10.
• Most can initiate/invite others
to participate in an activity.
• Most can communicate
immediate experiences.
• Most can attend to and follow
up to 2-step instructions.
• Most can cross residential street
intersections safely (look in both
directions, wait for traffic to clear
before crossing, obey lights and
signal signals). In contexts without
busy intersections, some can follow
socially acceptable rules necessary
to ensure personal safety.
• Some can travel independently
to familiar places.
• Most can communicate their
preferences about their
future goals, health care and
relationships (e.g. who they
prefer to spend time with), and
will often act in accordance
with these preferences.
• Some can apply existing abilities
in the context of semi-skilled
employment (i.e. involving the
performance of routine operations).
• Most remain naive in anticipating
full consequences of actions
or recognizing when someone
is trying to exploit them.
Literacy/numeracy
• Most can read sentences with
three common words and can
achieve a reading and writing level
up to that expected of someone
who has attended 4–5 years of
schooling (i.e. several years of
primary/elementary school).
• Most can choose the correct
number of objects.
• Most can count to 10 and
in some cases higher.
Severe
• Most will develop various
simple nonverbal strategies
to communicate basic needs.
• Some can self-initiate activities.
• Most can attend to and
respond to others.
• Most can separate one object
from a group upon request.
• Most can stop an activity
upon request.
• Most can use communication
strategies to indicate preferences.
• Most can self-initiate activities.
• Most can attend to and
recognize familiar pictures.
• Most can follow 1-step instructions
and stop an activity upon request.
• Most can distinguish between
“more” and “less”.
• Most can separate one object
from a group upon request.
• Most can use communication
strategies to indicate preferences.
• Most can self-initiate activities.
• Most can attend to and
recognize familiar pictures.
• Most can follow 1-step instructions
and stop an activity upon request.
• Most can distinguish between
“more” and “less”.
• Most can separate one object
from a group upon request.
Neurodevelopmental disorders | Disorders of intellectual development
103
Severity level
Early childhood
Childhood and adolescence
Adulthood
• Most can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress when
given concrete choices (e.g. with
visual aids).
Literacy/numeracy
• Most can make rudimentary marks
that are precursors to letters on
a page.
• Most can differentiate locations
and associate meanings (e.g. car,
kitchen, bathroom, school, doctor’s
office).
• Most can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress when
given concrete choices (e.g. with
visual aids).
• With support, some may be able
to apply existing abilities in order
to build skills for future unskilled
employment (i.e. involving
performing simple duties) or semiskilled employment (i.e. involving
performing routine operations).
Literacy/numeracy
• Most can recognize symbols.
• Many can recognize own name
in print.
• Most can differentiate locations
and associated meanings (e.g. car,
kitchen, bathroom, school, doctor’s
office).
• Most can communicate their
preferences about their future
goals, health care and relationships
(e.g. who they prefer to spend time
with) when given concrete choices
(e.g. with visual aids).
• Some can apply existing skills
to obtain unskilled employment
(i.e. involving performing simple
duties) or semi-skilled employment
(i.e. involving performing routine
operations) with appropriate social
and visual/verbal support.
Literacy/numeracy
• Most can recognize common
pictures (e.g. house, ball, flower).
• Many can recognize letters from
an alphabet.
Profound
• Many will develop nonverbal
strategies to communicate
basic needs.
• Most can attend to and respond
to others.
• Most can start or stop activities
with prompts and aids.
• Many can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress when
given concrete choices (e.g. with
visual aids).
Literacy/numeracy
• Children with profound disorders
of intellectual development will not
learn to read or write.
• Most will develop strategies to
communicate basic needs and
preferences.
• Most can recognize familiar people
in person and in photographs.
• Most can perform very simple tasks
with prompts and aids.
• Some can separate one object from
a group upon request.
• Some can differentiate locations
and associated meanings (e.g. car,
kitchen, bathroom, school, doctor’s
office).
• Many can express their likes and
dislikes in relationships (e.g. who
they prefer to spend time with),
activities, food and dress when
given concrete choices (e.g. with
visual aids).
• Most will develop nonverbal
strategies and some utterances/
occasional words to communicate
basic needs and preferences.
• Most can attend to and recognize
familiar pictures.
• Most can perform very simple tasks
with prompts and aids.
• Some can separate one object from
a group upon request.
• Some can differentiate locations
and associated meanings (e.g.
car, kitchen, bathroom, school,
doctor’s office).
• Many can communicate their
preferences about their future
goals, health care and relationships
(e.g. who they prefer to spend time
with) when given concrete choices
(e.g. with visual aids).
Table 6.1. contd
Neurodevelopmental disorders
Neurodevelopmental disorders | Disorders of intellectual development
Note: the presence or absence of particular behavioural indicators listed in the table is not sufficient to assign a diagnosis of disorder of intellectual development.
Clinical judgement is a necessary component in determining whether an individual has a diagnosable disorder, and diagnosis relies on the following key assumptions being met:
• Limitations in present functioning have been considered within the context of community environments typical of the individual’s age peers and culture.
• Valid assessment has considered cultural and linguistic diversity, as well as differences in communication, sensory, motor and behavioural factors.
• Within an individual, limitations are recognized to often coexist alongside strengths and both were considered during the assessment.
• Limitations are described, in part, to develop a profile of needed support.
• It is recognized that with appropriate support over a sustained period, the life functioning of the affected person generally will improve.
• Please consult the CDDR for disorders of intellectual development and, if applicable, autism spectrum disorder for guidance on how to determine the severity level.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.2. Behavioural indicators of adaptive behaviour, early childhood (up to 6 years of age)
Severity level
Conceptual
Social
Practical
Mild
• Most can perform basic listening
skills with a 15-minute attention
span. They will need help to sustain
their attention for 30 minutes.
• Most are able to follow simple
2-step instructions. They will
need help following a 3-step or
“if-then” type of instruction.
• Most can state their age and
name and identify close family
members when asked.
• Many will have a 100-word
vocabulary. Most will ask “wh”
question (who, what, where,
why), but will need help using
pronouns and tense verbs.
• Most are not able to give a detailed
account of their experiences.
• Most will understand the simple
concepts of time, space, distance
and spatial relationships.
Literacy
• Many will not learn reading/
writing skills. If present, reading
skills will be limited to identifying
some letters of the alphabet. Only
some will be able to recognize
their own name in print.
• Most can perform independently
basic skills related to social
interaction – such as imitation
and showing affection to familiar
people, as well as friend-seeking
behaviour – expressing emotions
and answering basic questions.
• Most will need frequent
encouragement and assistance
in offering help to others, sharing
interests or perspective taking.
They are able to engage in play
with others, even with minimal
supervision, although they will
need assistance taking turns,
following rules or sharing.
• Most are able to demonstrate
polite behaviour (saying “please”,
“thank you”), although they
may need help apologizing,
demonstrating appropriate
behaviour with strangers or waiting
for the appropriate moment to
speak in a social context.
• Most will need help to modify their
behaviour in accordance with
changing social situations or when
there is a change in their routines.
• Most will learn the majority of basic
eating, washing face and hands,
toileting and self-care skills.
• Most will acquire independence
in dressing (nut may need
help to button/fasten clothes)
and night-time continence.
• Most can use simple
household devices.
• Most will need support with
bathing, using utensils, toileting
such as cleaning after passing
stools, and brushing teeth.
• Most can learn the concept of
danger and avoid hot objects.
• Most will be able to help with
simple household chores
independently, but will often need
assistance with more complex
tasks such as putting away clothes
or cleaning up their rooms.
• With some assistance, most
can learn the concept of money
(although they will be unable to
learn the value of the different
denominations, e.g. coins),
can count to 10, and can follow
basic rules around the home.
• Most will be unable to learn
days of the week, and learn and
remember phone numbers.
Moderate
• Most will independently point to
common objects when asked and
follow 1-step instructions. Some
will need support to perform
basic skills such as following
simple 2-step instructions.
• Most can state their own name.
• Most will have basic
communication skills such as
formulating one-word requests,
using simple phrases and using
other people’s customary forms
of address (mommy, papa, sister),
but will need help with full names.
• Most will speak at least 50
words and name/point to at
least 10 objects when asked.
• Most are not able (or will
need considerable support)
to use past tense verbs,
pronouns or “wh” questions.
Literacy
• Most will not learn reading or
writing skills, but will know
how to use pens and pencils
and make marks on a page.
• Most are able to perform
independently some of the basic
skills related to social interaction,
although they might need
some help making new friends,
answering basic social questions
or expressing their emotions.
• Most are able to play with peers
and show interest in, play or
interact with others, but may need
more supervision/support to play
cooperatively with others, play
symbolically, take turns, follow
rules of a game and share objects.
• Most will not be able to perform
more complex social skills involving
interpersonal interactions such as
offering help to others, empathy,
sharing their interests with
others or perspective taking.
• Most can learn the majority of
basic eating skills, but may need
more assistance than their sameage peers with toilet training
and dressing themselves (some
help needed to button/fasten).
• Most will learn to ask to use the
toilet, drink from a cup, feed
themselves with a spoon, and
some may become toilet trained
during daytime. Most will often
need support with brushing teeth,
bathing and using utensils.
• With some support, most can learn
to use simple household devices
and carry out simple chores such
as putting away their footwear.
• Most can learn the concept of
danger, although some assistance
will be needed when using
sharp objects (e.g. scissors).
• Many will be able to help with very
simple household chores such as
cleaning fruits and vegetables.
• Most will not acquire understanding
of the concept of money and time.
Neurodevelopmental disorders | Disorders of intellectual development
105
Severity level
Conceptual
Social
Practical
Severe
• Most can perform independently
the most basic skills such as wave
goodbye, identify parent/caregiver,
point to a desired object and
point or gesture to indicate their
preference, and understanding
the meaning of yes and no.
• Most will need support to point
to/identify common objects,
follow 1-step instructions, and
sustain their attention to listen to
a story for at least 5 minutes.
• Most will not be able to state
their age correctly and will speak
less than 50 recognizable words.
They may need help formulating
1-word requests and using
first names or nicknames of
familiar people, naming objects,
answering when called upon,
and using simple phrases.
Literacy
• Most will not learn reading
and writing skills.
• Most will need help to perform
basic social skills such as
imitation or showing interest
and preferences in social
interactions with their peers.
• Most are able to show interest
when someone else is playful
and to play simple games.
• Most will need significant support
to play in a cooperative way,
play symbolically or seek others
for play/leisure activities.
• Most will need significant help
with transitions – changing from
one activity to another or an
unexpected change in routine.
• Most will need significant help
using polite social responses such
as “please” and “thank you”.
• Most will not be able to engage
in turn-taking, following
rules or sharing objects.
• Most can learn many of the
basic eating skills but will need
substantially more assistance than
their same-age peers with toilet
training, learning to use a cup and
spoon, and putting on clothes.
• Most can learn to use simple
household devices with
consistent support.
• Most will have difficulty
learning to master many selfcare skills, including using
the toilet independently.
• Most will not be able to learn
the concept of danger, and
will require close supervision
in areas such as the kitchen.
• Some may learn basic cleaning
skills such as washing hands but
will consistently need assistance.
• Most will not learn the concept
of money, time or numbers.
Profound
• Most will master only the most
basic communication skills
such as turning their eye gaze
and head towards a sound.
• Children with profound disorders
of intellectual development will
typically need prompting to
orient towards people in their
environment, respond when their
name is called, and understand
the meaning of yes and no.
• Children with profound disorders
of intellectual development
are typically able to cry when
hungry or wet, smile and make
sounds of pleasure, but it may be
difficult to get their attention.
Literacy
• Children with profound disorders
of intellectual development will
not learn to read or write.
• Most may be able to perform
only the most basic social skills
such as smiling, orienting their
gaze, looking at others/objects,
or showing basic emotions.
• Some might be able to perform
other basic social skills
with considerable support/
prompting, such as showing
preference for people or objects,
imitating simple movements
and expressions, or engaging in
reciprocal social interactions.
• Some can show interest when
someone else is playful, but
will need considerable support
to play simple games.
• Most will have difficulty
adapting to changes and
transitions in activity/location.
• Most will be unable to follow
rules of a social game.
• Most will need help
performing even the most
basic eating, dressing,
drinking and bathing skills.
• Most will be unable to learn
to be independent using the
toilet, being dry during the day,
bathing or washing self at the
sink, and using a fork and knife.
• Most will need constant
supervision around potentially
dangerous situations in the
home and community.
• Most will be unable to clean up
after themselves and will need help
with even basic chores, such as
picking up belongings to put away.
• Most will not be able to learn
to use the telephone or other
simple devices around the
home independently.
Note: the behavioural indicators in the table are intended to be used by the clinician in determining the level of severity of the disorder of intellectual development, either as a
complement to properly normed, standardized tests, or when such tests are unavailable or inappropriate given the individual’s cultural and linguistic background. Use of these
indicators is predicated on the clinician’s knowledge of and experience with typically developing individuals of comparable age. Unless explicitly stated, the behavioural indicators
of intellectual functioning and adaptive behaviour functioning for each severity level are what are typically expected to be mastered by the individual by 6 years of age. Please
consult the CDDR for disorders of intellectual development and, if applicable, autism spectrum disorder for guidance on how to determine the severity level.
Table 6.2. contd
Neurodevelopmental disorders
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.3. Behavioural indicators of adaptive behaviour, childhood and adoles­
cence (6–18 years of age)
Severity level
Conceptual
Social
Practical
Mild
• Most will need some help
to sustain their attention
for a 30-minute period.
• Most can follow 3-step instructions.
• Most will acquire sufficient
communication skills to use
pronouns, possessives and
regular tenses, as well as be able
to ask “wh” question (e.g. who,
what, where, when or why).
• Many will need support to tell a
narrative story or to give someone
simple directions. They will also
need assistance to explain their
ideas using multiple examples,
detail short-term goals and steps
to achieve them, stay on the
topic in group conversations and
move from one topic to another.
Literacy
• Most will have reading and
writing skills that are limited to
approximately those expected of
someone who has attended 3–4
years of primary/elementary school.
• Some may have a more concrete
understanding of social
situations, and may need support
understanding some types of
humour (e.g. teasing others),
making plans and knowing to let
others know about these plans as
needed, controlling their emotions
when faced with disappointment,
and knowing to avoid dangerous
activities or situations that may
not be in their best interest (e.g.
taken advantage of or exploited).
• Some may need some support
initiating conversation,
organizing social activities with
others or talking about shared
interests with peers/friends.
• Some may need substantial
support to talk about personal
things and emotions or
understand social cues.
• Most are able to play outdoor
sports or other social games in
groups, although they need help
to play games with more complex
rules (e.g. board games).
• Most will learn to perform
independently most dressing,
toileting and eating skills.
• Most will learn to manage
activities of daily living
independently, such as brushing
teeth, bathing and showering.
• Most will need some support
getting around the community and
being safe (e.g. although they will
know to stay to the side of routes
with car traffic, they may continue
to need support to check for
traffic before crossing a street).
• Many may be vulnerable to being
taken advantage of in social
situations. They may continue to
need some support for telling time,
identifying correct day/dates on
calendar, making and checking
the correct change at the store,
and being independent with basic
health-maintaining behaviours.
• If available, many can learn
to use computers and cell
phones for school and play.
• Most will learn basic work
skills at nearly the same pace
as their same-age peers, but
will require greater repetition
and structure for mastery.
Moderate
• Most will need help performing
skills such as following instructions
containing “if-then”, and sustaining
their attention to listen to a story
for at least a 15-minute period.
• Most can say at least 100
words, use negatives, use
simple sentences and state their
first and last name and their
locality/place of residence.
• Some may need help using
pronouns, possessives
or past tense verbs.
• Some may need support
telling basic parts of a story
or asking “wh” questions (e.g.
when, where, why, who).
• Most will not learn complex
conversation skills (i.e. expressing
their ideas in an abstract manner
or in more than one way).
• Some may need support
expressing their emotions or
concerns, knowing when others
might need their help, showing
emotions appropriate to the
situation/context, or knowing
what others like or want.
• Most will need considerable help
initiating a conversation, waiting
for the appropriate moment to
speak, meeting friends and going
on social outings or talking about
shared interests with others.
• Most will need help following
rules when playing simple games
or going out with friends.
• Some will need support when
changing routines and transitioning
between activities/places.
• Most can learn to feed
themselves, use the toilet and
dress (including putting shoes/
footwear on the correct feet).
• Most will often continue to need
support to attain independence
for bathing and showering,
brushing teeth, selecting
appropriate clothing, and
being independent and safe in
the home and community.
• Most will continue to have difficulty
using a knife to cut food, using
cooking appliances safely, using
household products safely, and
doing household chores.
Neurodevelopmental disorders | Disorders of intellectual development
107
Severity level
Conceptual
Social
Practical
Literacy
• Most will have reading and
writing skills that will be limited to
approximately those expected of
someone who has attended 2 years
of primary/elementary school.
• Most may need support with
reading simple stories, writing
simple sentences, and writing more
than 20 words from memory.
• Most will be able to say the
names of a few animals, fruits
and foods prepared in the home.
• Some will need support in behaving
appropriately in accordance
with social situations, and
knowing what to do in social
situations involving strangers.
• Most individuals will not be
able to share information with
others about their past day’s
events/activities, and will need
support managing conflicts or
challenging social interactions
and recognizing/avoiding
dangerous social situations.
• Most will not acquire an
understanding of taking
care of their health.
• Most will learn basic work skills
but later than same-age peers
Severe
• Most will be able independently
to make simple one-word
requests, use first names of
familiar individuals and name
at least 10 familiar objects.
• Some may need help following
instructions, and will not
be able to use pronouns,
possessives or regular past
tenses, or state their age.
• With help, some may be able
to ask “wh” questions (e.g.
when, why, what, where), use at
least 100 recognizable words,
use negatives, and relate their
experiences in simple sentences.
Literacy
• Most will have reading and
writing skills that will be
limited to identifying some
letters of the alphabet.
• Most will be able to count up to 5.
• Some may need support
demonstrating friend-seeking
behaviour, or engaging in
reciprocal social interactions.
• Most will need help expressing
their emotions or showing empathy.
• Most will not know that they should
offer help to others without cues
or prompting, show appropriate
emotions in social situations,
engage in conversations or ask
others about their interests.
• Most will need support to
play cooperatively.
• Most will need help with
transitions – changing from
one activity to another, or an
unexpected change in routine.
• With considerable help, some might
be able to start/end a conversation
appropriately, and say “please” and
“thank you” when appropriate.
• Most will have difficulty
following social rules, as well
as rules associated with games
such as turn-taking or sharing
toys. Most will be unable to
participate in social or other
games with complex rules.
• Most can learn to independently
put on and take off clothing,
feed themselves with hand or
a spoon, and use the toilet.
• They will often continue to need
support to attain independence
for putting shoes or other
footwear on the correct feet,
buttoning and fastening clothing,
bathing and showering.
• Most individuals will not learn
the rules and safe behaviours
in the home and community,
doing household chores or
checking for correct change
when purchasing items.
• Some will learn basic work skills
but later than same-age peers.
Table 6.3. contd
Neurodevelopmental disorders
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Severity level
Conceptual
Social
Practical
Profound
• Most will have basic
communication skills such as
orienting their eye gaze and turning
their head to locate a sound,
responding to their name, getting
a parent/caregiver’s attention,
expressing their needs, and
demonstrating an understanding
of the meaning of yes and no.
• With significant support, some
will be able to wave goodbye,
use their parent/caregiver’s
name, and point to objects to
express their preferences.
• Most indicate when there are
hungry or wet by making a
vocalization or crying, smile,
and make sounds to indicate
they are happy/sad.
• Some may not be able to
effectively use communication
to get the attention of others
in their environment.
Literacy
• Most will not learn to read or write.
• Most will need some help to
perform basic social skills
such as showing interest and
affection for people familiar
to them, engaging in social
interactions, or discriminating
between acquaintances.
• Some can perform certain social
skills such as imitation, showing
interest in peers or empathy.
• For some, transitioning between
social contexts and activities
will elicit negative reactions
if not done with support.
• Most will not be able to engage in
cooperative social play, and will
need a lot of help moderating their
behaviour to different social cues.
• Most will need exceptional
support with basic hygiene
and washing, picking up after
themselves, clearing their place
at the kitchen table, being safe in
the kitchen, and using hot water.
• Most will be unable to learn
to prepare foods or assist in
the kitchen, or use simple
household devices (e.g.
switches, stoves, microwaves).
• Most will not learn rules
and safe behaviours in the
home and community.
• Most will require a lot of
supervision to remain on task and
be engaged in basic vocational
or pre-vocational skills.
Table 6.3. contd
Note: the behavioural indicators in the table are intended to be used by the clinician in determining the level of severity of the disorder of intellectual development, either as a
complement to properly normed, standardized tests, or when such tests are unavailable or inappropriate given the individual’s cultural and linguistic background. Use of these
indicators is predicated on the clinician’s knowledge of and experience with typically developing individuals of comparable age. Unless explicitly stated, the behavioural indicators
of intellectual functioning and adaptive behaviour functioning for each severity level are what are typically expected to be mastered by the individual by 18 years of age. Please
consult the CDDR for disorders of intellectual development and, if applicable, autism spectrum disorder for guidance on how to determine the severity level.
Neurodevelopmental disorders | Disorders of intellectual development
109
Table 6.4. Behavioural indicators of adaptive behaviour, adulthood (18 years of age and over)
Severity level
Early childhood
Childhood and adolescence
Adulthood
Mild
• Most will master listening and
communication skills, although
some may need help to stay on
topic in group conversations, move
from one topic to another, express
ideas in more than one way or state
their complete home address.
• Most will probably not be able
to give complex directions and
describe long-term goals.
Literacy
• Most can read and understand
material up to that expected of
someone who has attended 3 or
4 years of primary/elementary
school, and will master some
writing skills, although they
may have difficulty writing
reports and long essays.
• Most can meet others
independently for the purpose of
making new friends, participate in
social outings on a regular basis,
and talk about personal feelings.
• Most can initiate a conversation
independently and talk about
shared interests with others.
• Most can understand social
cues, and are able to regulate
their conversation based
on their interpretation of
other people’s feelings.
• Most are able to play complex
social games and team sports,
although they may need support
with understanding the rules.
• Most can learn to weigh the
possible consequences of their
actions before making a decision
in familiar situations but not in
new or complex situations, and
will know right from wrong.
• Most will need help recognizing
when a situation or relationship
might pose dangers or
someone might be manipulating
them for their own gain.
• Most can initiate planning of a
social activity with others. Some
can be engaged in an intimate
relationship, whereas others might
need more support to do so.
• Most will be independent in
household chores, be safe
around the home, and use the
telephone and TV; some will learn
to operate a gas or electric stove.
• Most will often continue to
need some support to attain
independence with more complex
domestic skills (e.g. small
household repairs), comparative
shopping for consumer products,
following a healthy diet and being
engaged in health-promoting
behaviours, caring for themselves
when sick or knowing what to
do when they are sick/ill.
• Many can learn to live and work
independently, working at a
part-time or full-time job with
competitive wages – support at
work will depend on the level of
complexity of the work, and may
fluctuate with life transitions.
• Some can learn to drive a motor
vehicle or a bicycle, manage simple
aspects of a bank account, prepare
simple meals and, if available,
use a computer or other digital
devices. Many will learn to use
public transport with minimal help.
• Most will continue to need support
with more complex banking
needs, paying bills, driving on
busy roads and parenting skills.
Moderate
• Most will need considerable
support to be able to attend
to various tasks for more
than a 15-minute period
and to follow instructions
or directions from memory
(i.e. with a 5-minute delay).
• Most will master simple
descriptions, using “wh” questions
(e.g. what, when, why, where)
and relating their experiences
using simple sentences.
• With help, most are able to
follow 3-step instructions.
• Most will continue to need
help frequently with using
language containing past
tenses and describing their
experiences in detail.
• Most will not learn more complex
conversation skills (e.g. expressing
ideas in more than one way).
• Some will need help learning
how to share interests or
engaging in perspective taking.
• Some may need support initiating
conversations and introducing
themselves to unfamiliar people.
• Most will need significant
support engaging in regular
social activities, planning
social activities with others,
understanding social cues, and
knowing what are appropriate or
inappropriate conversation topics.
• Most will need significant support
engaging in social activities
requiring transportation.
• Most are unable to be engaged in
more social or other games with
complex rules (e.g. board games).
• Some will learn to master dressing
(but may need some help
selecting appropriate clothing
to wear for weather), washing,
eating and toileting needs.
• Most are able to be safe around
the home, use the telephone,
use the basic features of a TV
and use simple appliances/
household articles (e.g. switches,
stoves, microwaves).
• Some may continue to need
support with bathing and
showering, using more complex
household appliances (e.g. stoves)
safely, meal preparation, or
using cleaning products safely.
• Many will understand the function
of money but will struggle with
making change, budgeting
and making purchases without
being told what to buy.
Neurodevelopmental disorders
Neurodevelopmental disorders | Disorders of intellectual development
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Severity level
Early childhood
Childhood and adolescence
Adulthood
Literacy
• Most will acquire some reading
and writing skills, such as letters of
the alphabet, writing at least three
simple words from an example,
and writing their own first and last
name. They will need significant
support to write simple sentences
or read simple stories at about
the level expected of someone
who has attended 2 years of
primary/elementary school.
• Most will need help providing
socially polite responses such
as “please” and “thank you”.
• Most are unable to recognize
when a social situation might
pose some danger to them (e.g.
potential for abuse or exploitation).
• Most will need support being
safe in the community and
living independently. They
will need substantial support
for employment, including
finding and keeping a job.
• Most will not be able to travel
independently to new places,
have a developed concept of time
sufficient to tell time independently
and know when they are late.
Severe
• Most will often need lifelong
support to recall and comply
with instructions given 5 minutes
prior, and sustain their attention
to a story for a 15-minute
period. Most are able to listen
and attend to a story for a
period of at least 5 minutes.
• Most can make sounds or gestures
to get the attention of individuals
in their environment, and can
make their needs known.
• They may need help using simple
phrases, describing objects and
relating their experiences to others,
speaking at least 100 recognizable
words, and using negatives,
possessives and pronouns,
and asking “wh” questions.
Literacy
• Reading and writing skills will be
limited to identifying some letters
of the alphabet, copying simple
words from an example and
attempting to write their name.
• All will need help in social
situations, showing and expressing
their emotions in an appropriate
manner, and engaging in a
reciprocal conversation with others.
• Most can play simple social games
such as catching and throwing a
ball, but may need help choosing
friends to play with. They will
need considerable help to play
symbolically and follow the rules
while playing games, such as
turn-taking or sharing toys.
• Most will need help with
transition – changing from
one activity to the next or an
unexpected change in routine.
• Most will not spontaneously use
polite forms such as “please”,
“excuse me”, “thank you” and
so on, or respectful/customary
ways of addressing others. They
will need significant support
starting, maintaining and ending
conversations with others.
• Most will not recognize when
a social situation might pose a
danger to them (e.g. potential
for abuse or exploitation) or
discern dangers potentially
associated with strangers.
• Most will need some support
for even basic personal
hygiene, domestic skills, home
and community skills.
• Most will be able to drink
independently from a cup and
learn to use basic utensils for
eating. Some may continue to
need support getting dressed.
• Many may learn independent
toileting if provided an established
routine. Most will be unable to care
for their own belongings, perform
household chores independently,
cooking or care for their health.
• Most will need substantial
support to travel independently,
plan and do shopping and
banking of any sort.
• Most will require significant support
to be engaged in paid employment.
Profound
• Most are able to turn their head
and eye gaze towards sounds in
their environment and respond
to their name when called.
• Most will use sounds and gestures
to get a parent/caregiver’s
attention or express their
wants, and some will have an
understanding of the meaning of
yes and no. Some are able with
prompting to wave goodbye, use
their parent’s/caregiver’s name /
customary ways of addressing
others, and point to objects to
express their preferences.
• Most will not spontaneously
show interest in peers or
unfamiliar individuals.
• With significant support,
most are able to imitate
simple actions/behaviours or
show concern for others.
• Most will not engage in reciprocal/
back-and-forth conversation.
• Most will not spontaneously use
polite forms such as “please”,
“excuse me”, “thank you” and so on.
• Most will need support performing
even the most basic self-care,
eating, washing and domestic skills.
• Some may learn independent
toileting during the day,
but night-time continence
will be more difficult.
• Most will have difficulty picking
out appropriate clothing, and
zipping and snapping clothes.
• Most will need supervision and
support for bathing, including
safely adjusting water temperature
and washing/drying.
Table 6.4. contd
Neurodevelopmental disorders | Disorders of intellectual development
111
Table 6.4. contd
Severity level
Early childhood
Childhood and adolescence
Adulthood
Profound
• Most will cry or make vocalizations
when hungry or wet, smile, and
make sounds of pleasure.
• Most are not able to follow
instructions or story being told.
• Most will have only rudimentary
knowledge of moving around
within their house.
Literacy
• Most will not learn to read or write.
• Most are unable to anticipate
changes in routines. Social
interactions with others will
be very basic and limited to
essential wants and needs.
• Most are unable to recognize
when a social situation might
pose some danger to them (e.g.
potential for abuse or exploitation).
• Most will be unable to clean or
care for their living environment
independently, including clothing
and meal preparation.
• All will need substantial support
with health matters, being safe
in the home and community, and
learning the concept of days
of the week and time of day.
• Most will be extremely limited
in their vocational skills, and
engagement in employment
activities will necessitate
structure and support.
Note: the behavioural indicators in the table are intended to be used by the clinician in determining the level of severity of the disorder of intellectual development either as
a complement to properly normed, standardized tests, or when such tests are unavailable or inappropriate given the individual’s cultural and linguistic background. Use of
these indicators is predicated on the clinician’s knowledge of and experience with typically developing individuals of comparable age. The behavioural indicators of intellectual
functioning and adaptive behaviour functioning for each severity level are what are typically expected to be mastered by the individual as an adult. Please consult the CDDR for
disorders of intellectual development and, if applicable, autism spectrum disorder for guidance on how to determine the severity level.
Neurodevelopmental disorders
Neurodevelopmental disorders | Disorders of intellectual development

03 - 6A01 Developmental speech and language disord
6A01 Developmental speech and language disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Developmental speech and language disorders
Developmental speech and language disorders are characterized by difficulties in understanding
or producing speech and language or in using language in context for the purposes of
communication. Developmental speech of language disorders include:
6A01.0 Developmental speech sound disorder
6A01.1 Developmental speech fluency disorder
6A01.2 Developmental language disorder
6A01.Y Other specified developmental speech or language disorder
6A01.Z Developmental speech or language disorder, unspecified.
Regional, social or cultural/ethnic language variations (e.g. dialects) must be considered when an
individual is being assessed for language abilities. For example, phonological memory tasks may
offer a less biased assessment compared to lexical tasks. A language history documenting all the
languages the child has been exposed to since birth can assist in determining whether individual
language variations are better explained by exposure to multiple languages rather than a speech
or language pathology per se.
Developmental speech sound disorder
Essential (required) features
• Persistent errors of pronunciation, articulation or phonology (i.e. how language-based
sounds are combined in culture-typical speech) that manifest as developmentally typical
speech sound errors that persist substantially beyond the expected age or as atypical speech
sound errors for the language spoken (e.g. word initial consonant deletion for Englishspeaking children) are required for diagnosis.
• The onset of speech sound difficulties occurs during the early developmental period.
• Speech sound difficulties result in significant limitations in the ability to communicate due
to reduced intelligibility of speech.
• The speech errors are not better accounted for by a disease of the nervous system affecting
the brain, peripheral nerves or neuromusculature (e.g. cerebral palsy, myasthenia gravis);
a sensory impairment (e.g. sensory neural deafness); or a structural abnormality (e.g. cleft
palate) or other medical condition.
Additional clinical features
• Children with developmental speech sound disorder may exhibit delays in the acquisition,
production and perception of spoken language.
6A01
6A01.0
Neurodevelopmental disorders | Developmental speech and language disorders
113
Neurodevelopmental disorders
• Phonological speech sound errors may be consistent or inconsistent. They often involve
classes of sounds (e.g. incorrectly producing sounds in the same manner), a different
place of articulation, or changes in syllable structure (e.g. deletion of final consonants or
reducing consonant clusters to single consonants).
• If the speech errors are consistently produced, familiar listeners may be able to accommodate
and decode the speech. However, when the rate of speech increases, even familiar listeners
may not be able to understand the individual.
• Developmental speech sound disorder may be associated with imprecision and
inconsistency of oral movements required for speech, especially in young children
(also called childhood apraxia or dyspraxia of speech), resulting in difficulty producing
sequences of speech sounds, specific consonants and vowels, and appropriate prosody
(intonation and rhythm of speech). There may be some associated oral-motor dysfunction
affecting early feeding, sucking and chewing, blowing, and imitating oral movements and
speech sounds, but not with the weakness, slowness or incoordination found in dysarthria.
• Developmental speech sound disorder commonly co-occurs with other neurodevelopmental
disorders, such as attention deficit hyperactivity disorder, developmental speech fluency
disorder and developmental language disorder.
Boundary with normality (threshold)
• Children vary widely in the sequence and age at which they acquire speech sounds. Such
normal variation does not reflect the presence of developmental speech sound disorder. In
contrast, children with developmental speech sound disorder exhibit persistent problems
that cause significant limitations in the ability to communicate due to reduced intelligibility
of speech. Up until the age of 4 years, various speech sound errors are common among
children with typically developing speech sound acquisition, but communication remains
relatively intact despite these errors, relative to same-aged peers.
Course features
• Many young children with developmental speech sound disorder experience remission by
school age. Among young children diagnosed in early childhood, up to 50–70% will exhibit
academic difficulties throughout their schooling, even if the speech sound difficulties
themselves have remitted.
• Compared to children and adolescents with a sole diagnosis of developmental speech
sound disorder, those with a co-occurring developmental language disorder are more
likely to develop other mental, behavioural and neurodevelopmental disorders such as
anxiety and fear-related disorders or attention deficit hyperactivity disorder. They are
also more likely to exhibit greater difficulties academically, socially and adaptively by late
childhood and adolescence.
Neurodevelopmental disorders | Developmental speech and language disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Developmental presentations
• Prevalence rates vary but generally decrease with age such that prevalence can be as high
as 16% at 3 or 4 years of age, approximately 4% at 6 years of age and 3.6% by 8 years of age.
Therefore, many preschool-aged children diagnosed with developmental speech sound
disorder exhibit typical speech sound development by the time they begin school.
• Some children with symptoms of developmental speech sound disorder early in life may
only experience interference with functioning when they enter school, when the demands
of the learning environment exceed their current abilities.
• Co-occurrence of other neurodevelopment disorders is more likely among children with
persistent developmental speech sound disorder (whose speech sound errors continue
beyond 8 or 9 years of age). In particular, these children are more likely to develop language
impairments and reading difficulties, and tend to experience worse outcomes.
Sex- and/or gender-related features
• Developmental speech sound disorder is more prevalent among boys, especially at younger
ages. Early speech difficulties in girls appear more likely to resolve by school age. Gender
differences decline with age: the ratio of boys to girls affected appears to be 2:1 or 3:1 in
early childhood, and to decline to 1.2:1 by 6 years of age.
• Boys are more likely to experience co-occurring language impairments.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with disorders of intellectual development
Individuals with a disorder of intellectual development may exhibit impaired speech production.
However, individuals with developmental speech sound disorder do not typically also have
significant limitations in intellectual functioning and adaptive behaviour. If speech production
difficulties require separate clinical attention in the context of a disorder of intellectual development,
an additional diagnosis of developmental speech sound disorder may be assigned.
Boundary with developmental speech fluency disorder and developmental
language disorder
Like developmental speech sound disorder, developmental speech fluency disorder and
developmental language disorder can result in reduced intelligibility that significantly affects
communication. Developmental speech fluency disorder is characterized by disruption of the
normal rhythmic flow and rate of speech. Developmental language disorder is characterized by
persistent difficulties in the acquisition, understanding, production or use of language. In contrast,
developmental speech sound disorder is characterized by errors of pronunciation that are outside
the limits of normal variation for chronological or developmental age.
Neurodevelopmental disorders | Developmental speech and language disorders
115
Neurodevelopmental disorders
Boundary with selective mutism
Selective mutism is characterized by consistent selectivity in speaking, such that a child demonstrates
adequate speech production in specific situations (typically at home) but predictably fails to speak
in others (typically at school). Selective mutism can occur in the presence of developmental speech
sound disorder, and both diagnoses may be assigned if warranted.
Boundary with dysphonia
Dysphonia is characterized by abnormal voice production or absences of vocal quality, pitch,
loudness, resonance or duration. It can be caused by voice strain or overuse, by structural laryngeal
anomalies, or by diseases of the nervous system. It may result in the distortion of speech sounds
due to the abnormal voice quality. In contrast, developmental speech sound disorder involves the
omission or substitution of speech sounds and also includes distortion of speech sounds (e.g. due
to incorrect tongue placement) rather than abnormal voice quality characteristic of dysphonia.
Boundary with dysarthria
Dysarthria is a motor speech disorder directly attributable to a disease of the nervous system or to
either congenital or acquired brain injury. Dysarthria is characterized by difficulties with the range,
rate, force, coordination and sustainability of movements throughout the vocal tract (i.e. trunk,
larynx, palate, tongue, lips, jaw and face) that are required for speech. These motor difficulties
often also cause frank difficulties in eating, drinking, swallowing or saliva control. A diagnosis of
developmental speech sound disorder should not be assigned in these cases. Rather, a diagnosis of
secondary speech or language syndrome should be assigned in addition to the associated medical
condition if the speech sound difficulties are a specific focus of clinical attention.
Boundary with secondary speech or language syndrome
The diagnosis of developmental speech sound disorder should not be assigned in the presence
of a disease of the nervous system affecting the brain, peripheral nerves or neuromusculature
(e.g. cerebral palsy, myasthenia gravis); sensory impairment (e.g. sensory neural deafness); or
structural impairment (e.g. cleft palate), although speech sound production difficulties may be a
presenting feature of any of these conditions. In these cases, a diagnosis of secondary speech or
language syndrome should be assigned in addition to the associated medical condition if the speech
sound difficulties are a specific focus of clinical attention.
Developmental speech fluency disorder
Essential (required) features
• Frequent or pervasive disruption of the normal rhythmic flow and rate of speech
characterized by repetitions and prolongations in sounds, syllables, words and phrases,
as well as blocking (inaudible or silent fixations or inability to initiate sounds) and word
avoidance or substitutions, is required for diagnosis.
• The speech dysfluency is persistent over time.
• The onset of speech dysfluency occurs during the developmental period, and speech
fluency is markedly below what would be expected based on age.
• Speech dysfluency results in significant impairment in social communication or in
personal, family, social, educational, occupational or other important areas of functioning.
• The speech dysfluency is not better accounted for by a disorder of intellectual development,
a disease of the nervous system, a sensory impairment or a structural abnormality.
6A01.1
Neurodevelopmental disorders | Developmental speech and language disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Developmental speech fluency disorder includes cluttering, in which speech tends to be
rapid, erratic and dysrhythmic, with breakdown in fluency and clarity, often with deletion
or collapsing of syllables and omissions of word endings.
• Developmental speech fluency disorder may be accompanied by physical tension in
the speech musculature, as well as body tension, struggle behaviour and secondary
mannerisms, such as facial grimacing, eye blinking, head movements, and arm and leg
movements such as leg tapping or fist clenching.
• Developmental speech fluency disorder is often accompanied by anxiety in anticipation of
speaking and avoidance of speaking.
• The extent of the problem varies across situations and can be more severe when there is
pressure to communicate.
• Developmental speech fluency disorder may be associated with a broader range of speech
and language abnormalities.
• Occasionally, onset of dysfluency can be related to a significant psychological event such
as bereavement, and is sometimes referred to as “psychogenic stammering”. When this
occurs during the developmental period, it may be diagnosed as developmental speech
fluency disorder.
• Approximately 60% of children with developmental speech fluency disorder exhibit cooccurring developmental speech and language disorders.
• Among adolescents and adults with chronic speech dysfluencies, social anxiety is common
and may exacerbate dysfluency. As many as 40–60% of these individuals meet the diagnostic
requirements for social anxiety disorder.
Boundary with normality (threshold)
• Many typically developing children show minor dysfluencies during the preschool years.
Course features
• The course of developmental speech fluency disorder may be relatively brief in many cases,
with the majority of children (65–85%) remitting, without intervention, prior to puberty.
Among these children, recovery is typically within the first 2 years after onset.
• The impact of developmental speech fluency disorder may be evident as early as 3 years of
age, with impairments in emotional, behavioural and social domains compared to typically
developing peers.
Neurodevelopmental disorders | Developmental speech and language disorders
117
Neurodevelopmental disorders
• A more persistent course is associated with male gender, family history of developmental
speech fluency disorder, age at onset of greater than 3–4 years of age, duration of more
than 1 year, and co-occurring developmental language disorder. More severe presentations
of the disorder in childhood are more likely to persist into adolescence and adulthood.
Developmental presentations
• Developmental speech fluency disorder emerges early in the developmental period,
typically between 2.5 and 4 years of age. Around 5–8% of preschool-aged children exhibit
stuttering; 80–90% of cases develop by age 6, and onset after age 9 is rare. The lifetime
incidence of stuttering is estimated at 5%, whereas population prevalence is estimated at
approximately 1%.
• Dysfluency tends to emerge gradually and may worsen as the individual becomes aware of
their fluency difficulty. This may lead to development of mechanisms to avoid dysfluency
or the associated emotional discomfort, further impairing speech (e.g. avoiding public
speaking or limiting speech to simple and short phrases).
Sex- and/or gender-related features
• Across the developmental period, boys are more commonly affected. Among preschoolaged children, the ratio of boys to girls with developmental speech fluency disorder is
estimated at 1.5:1. However, females are more likely to remit. Throughout school age and
into adulthood, affected males are estimated to outnumber affected females by a ratio of 4:1.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with developmental speech sound disorder and developmental language
disorder
Like developmental speech fluency disorder, developmental speech sound disorder and
developmental language disorder can result in reduced intelligibility that significantly affects
communication. Developmental speech sound disorder is characterized by errors of pronunciation
that are outside the limits of normal variation for chronological or developmental age. Developmental
language disorder is characterized by persistent difficulties in the acquisition, understanding,
production or use of language. In contrast, developmental speech fluency disorder is characterized
by disruption of the normal rhythmic flow and rate of speech. If the diagnostic requirements for
both developmental fluency disorder and another developmental speech and language disorder are
met, both diagnoses may be assigned.
Neurodevelopmental disorders | Developmental speech and language disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with primary tics and tic disorders, including Tourette syndrome
Dysfluency associated with other movements of the face or body that coincide in time with
repetitions, prolongations or pauses in speech flow needs to be differentiated from complex tics.
Tics do not involve the marked speech dysfluency that characterizes a developmental speech
fluency disorder.
Boundary with diseases of the nervous system
Diseases of the nervous system affecting the anatomical and functional mechanisms for speech
output can sometimes give rise to speech dysfluency, but are distinguished on examination by the
presence of positive neurological signs.
Developmental language disorder
Essential (required) features
• Persistent deficits in the acquisition, understanding, production or use of language (spoken
or signed) are required for diagnosis. Any of the following specific components of language
skill may be differentially impaired, with relative weaknesses in some and relative strengths
in others, or impairment may be more consistent across the different component skills:
• the ability to decompose words into constituent sounds and mentally manipulate those
sounds (i.e. phonological awareness);
• the ability to use language rules – for example, regarding word endings and how words
are combined to form sentences (i.e. syntax, morphology or grammar);
• the ability to learn, understand and use language to convey the meaning of words and
sentences (i.e. semantics);
• the ability to tell a story or have a conversation (i.e. narrative or conversational discourse);
• the ability to understand and use language in social contexts – for example, making
inferences, understanding verbal humour and resolving ambiguous meaning (i.e.
pragmatics).
• Language abilities are markedly below what would be expected based on age.
• The onset of language difficulties occurs during the developmental period – typically
during early childhood.
• Language deficits result in significant limitations in communication, with functional
impact in daily life at home, school or work.
• The language deficits are not better accounted for by a disorder of intellectual development,
autism spectrum disorder, another neurodevelopmental disorder, a sensory impairment,
or a disease of the nervous system, including the effects of brain injury or infection (e.g.
due to trauma, stroke, epilepsy or meningitis).
6A01.2
Neurodevelopmental disorders | Developmental speech and language disorders
119
Neurodevelopmental disorders
Specifiers for areas of language impairment
The main areas of language ability currently affected in developmental language disorders should
be characterized using one of the following specifiers, although these may vary over time:
Developmental language disorder with impairment of receptive and
expressive language
• This specifier should be applied when the ability to learn and understand spoken or signed
language (i.e. receptive language) is markedly below the expected level for the individual’s
age, and is accompanied by persistent impairment in the ability to produce and use spoken
or signed language (i.e. expressive language).
Developmental language disorder with impairment of mainly expressive language
• This specifier should be applied when the ability to produce and use spoken or signed
language (i.e. expressive language) is markedly below the expected level for the individual’s
age, but the ability to understand spoken or signed language (i.e. receptive language) is
relatively intact.
Developmental language disorder with impairment of mainly pragmatic language
• This specifier should be applied when the developmental language disorder is characterized
by persistent and substantial difficulties with the understanding and use of language in
social contexts – for example, making inferences, understanding verbal humour and
resolving ambiguous meaning. Receptive and expressive language skills are relatively
unimpaired, but pragmatic language abilities are markedly below the expected level for
the individual’s age, and interfere with functional communication to a greater degree than
with other components of language (e.g. syntax, semantics). This specifier should not be
used if the pragmatic language impairment occurs in the context of a diagnosis of autism
spectrum disorder.
Developmental language disorder with other specified language impairment
• This specifier should be applied if the developmental language disorder meets all the
diagnostic requirements of the disorder but the pattern of deficits in language is not
adequately characterized by one of the other available specifiers.
6A01.20
6A01.21
6A01.22
6A01.23
Neurodevelopmental disorders | Developmental speech and language disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• In typical development, understanding and production of the different components of
language are tightly correlated and develop in tandem. In developmental language disorder,
this developmental relationship may be out of step, with differential impairment in any of
the component language skills.
• Many children with developmental language disorder exhibit a discrepancy between
verbal and nonverbal ability, but this is not a requirement for diagnosis.
• Developmental language disorder frequently co-occurs with other neurodevelopmental
disorders, such as developmental speech sound disorder, developmental learning disorder,
attention deficit hyperactivity disorder, autism spectrum disorder and developmental
motor coordination disorder.
• Developmental language disorder is often associated with difficulties in peer relationships,
emotional disturbance and disruptive behaviours, particularly in school-aged children.
• Developmental language disorder often runs in families.
• Developmental language disorder can be a presenting feature in some individuals with
specific chromosomal anomalies, including sex chromosome anomalies. Where available,
chromosome testing can assist in identifying other health risks associated with specific
underlying chromosomal abnormalities. If a specific chromosomal or other developmental
anomaly is identified, this should be diagnosed in addition to the developmental
language disorder.
• Regression of language skills once acquired is not a feature of developmental language
disorder. Reported loss of early first words in the second year of life associated with a
decline in social and communication behaviours – and, more rarely, loss of language skills
after 3 years of age – may be a presentation of autism spectrum disorder. Language abilities
may also be lost due to diseases of the nervous system including acquired brain injury
from stroke, trauma or encephalopathy with or without overt epilepsy. Concomitant loss of
physical skills with language abilities may be indicative of a neurodegenerative condition.
When an underlying neurological cause has been identified, the condition should not be
diagnosed as developmental language disorder but rather as secondary speech or language
syndrome, which should be assigned in addition to the appropriate diagnosis for the
underlying condition.
Boundary with normality (threshold)
• Children vary widely in the age at which they first acquire spoken language and in the pace
at which language skills become firmly established. The majority of preschool-aged children
who acquire speech later than expected go on to develop normal language abilities. Very
early delays in language acquisition are therefore not indicative of developmental language
disorder. However, the absence of single words (or word approximations) by 2 years of age,
the failure to generate simple two-word phrases by 3 years of age, and language impairments
that are persistent over time are more likely to indicate developmental language disorder,
especially in the context of a known family history of language or literacy learning
problems. By 4 years of age, individual differences in language ability are more stable.
Neurodevelopmental disorders | Developmental speech and language disorders
121
Neurodevelopmental disorders
• Pronunciation and language use may vary widely depending on the social, cultural and
other environmental context (e.g. regional dialects). However, within any typical cultural
setting, a developmental language disorder is characterized by significant deficits in
language abilities relative to the person’s same-aged peers in the community. A bilingual
environment is not a cause of persistent language learning impairment.
Course features
• The course of developmental language disorder may vary with the type and severity of
symptom profile: impairment of receptive and expressive language (compared to those
with impairment of mainly expressive language) is more likely to be persistent, and is
associated with subsequent difficulties in reading comprehension.
• The particular pattern of language strengths and deficits may change over the course
of development.
• Unlike developmental speech sound and speech fluency disorders, developmental
language disorder is more likely to be maintained throughout development and into
adulthood: approximately 75% of individuals diagnosed with developmental language
disorder in childhood continue to meet the diagnostic requirements for the disorder
in late adolescence. The impact of these impairments continues to be evident into early
adulthood as behavioural, social, adaptive and communication problems, often with
lifelong social consequences.
Developmental presentations
• Developmental language disorder emerges early in development, though it can be
challenging to distinguish typical variations from impairments in language development
prior to age four. Diagnosis from 4 years of age onwards tends to yield a more stable
symptom presentation, and is more likely to be persistent.
• The prevalence of developmental language disorder among children is estimated at 6–15%,
but is more common among children with other co-occurring neurodevelopmental
disorders.
Sex- and/or gender-related features
• Developmental language disorder appears to affect more boys than girls, though this
gender ratio varies across clinical and population-based samples (from 1.3:1 to 6:1).
• Boys appear to be more likely than girls to experience co-occurring developmental
language and developmental speech sound disorders.
Neurodevelopmental disorders | Developmental speech and language disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with disorders of intellectual development
Individuals with disorders of intellectual development may exhibit delays in language onset, or
development or impairment in language abilities, accompanied by generalized impairment in
intellectual and adaptive behaviour functioning. Developmental language disorder can occur with
varying levels of intellectual ability. If the diagnostic requirements of a disorder of intellectual
development are met and language abilities are significantly below what would be expected based on
the general level of intellectual functioning and adaptive behaviour, both diagnoses may be assigned.
Boundary with developmental speech sound disorder and developmental speech
fluency disorder
Like developmental language disorder with impairment in mainly expressive language,
developmental speech sound disorder and developmental speech fluency disorder can result in
reduced intelligibility that significantly affects communication. Developmental speech sound
disorder is characterized by errors of pronunciation that are outside the limits of normal variation
for chronological developmental age. Developmental speech fluency disorder is characterized by
disruption of the normal rhythmic flow and rate of speech. In contrast, developmental language
disorder is characterized by persistent difficulties in the acquisition, understanding, production or
use of language.
Boundary with autism spectrum disorder
Individuals with autism spectrum disorder often present with delayed language development. The
extent of functional language impairment, which refers to the capacity of the individual to use
language for instrumental purposes (e.g. to express personal needs and desires), should be coded
using the autism spectrum disorder functional language impairment specifier rather than using a
separate diagnosis of developmental language disorder. Moreover, pragmatic language impairment
is a characteristic feature of autism spectrum disorder even when other aspects of receptive and
expressive speech are intact. Autism spectrum disorder is differentiated from developmental
language disorder by the presence of additional impairments in social reciprocity as well as restricted,
repetitive and stereotyped behaviours. Unlike individuals with autism spectrum disorder, individuals
with developmental language disorder are usually able to initiate and respond appropriately to
social and emotional cues and to share interests with others, and do not typically exhibit restricted,
repetitive and stereotyped behaviours. An additional diagnosis of developmental language disorder
should not be assigned to individuals with autism spectrum disorder based solely on pragmatic
language impairment. However, both diagnoses may be assigned if there are additional specific
impairments in semantic, syntactic and phonological development.
Boundary with developmental learning disorder
Persistent deficits in the acquisition, understanding, production or use of language in developmental
language disorder may lead to academic learning difficulties, especially in literacy – including word
reading, comprehension and written output. If all diagnostic requirements for both developmental
language disorder and developmental learning disorder are met, both diagnoses may be assigned.
Boundary with selective mutism
Selective mutism is characterized by consistent selectivity in speaking, such that a child demonstrates
adequate language competence in specific social situations (typically at home) but predictably fails to
speak in others (typically at school). In contrast, language difficulties associated with developmental
language disorder are apparent in all settings. However, selective mutism and developmental
language disorder can co-occur, and both diagnoses may be assigned if warranted.
Neurodevelopmental disorders | Developmental speech and language disorders
123
Neurodevelopmental disorders
Boundary with diseases of the nervous system and sequelae of brain injury
or infection
Language impairment may result from brain damage due to stroke, trauma, infection (e.g. meningitis/
encephalitis), developmental encephalopathy with or without overt epilepsy, or syndromes of
regression (e.g. Landau-Kleffner syndrome or acquired epileptic aphasia). When language difficulties
are a specific focus of clinical attention, a diagnosis of secondary speech or language syndrome
should be assigned in addition to the associated medical condition.
Boundary with oral language delay or impairment due to hearing impairment
All children presenting with language impairment should have an assessment for hearing impairment
because language delay may be better accounted for by hearing impairment. Very young children
with hearing impairment usually compensate for lack of oral language by using nonverbal modes
of communication (e.g. gestures, facial expressions, eye gaze). However, presence of hearing loss
does not preclude a diagnosis of developmental language disorder if the language problems are
disproportionate relative to the severity of hearing loss. Developmental language disorder can be
assigned to children whose primary communication modality is through signing if exposure to
and opportunity to learn sign language has been adequate and the other features of the disorder
are present as they apply to sign language.
Boundary with other medical conditions involving loss of acquired language skills
When loss of acquired language skills occurs as a result of another medical condition (e.g. a stroke),
and language difficulties are a specific focus of clinical attention, a diagnosis of secondary speech
or language syndrome should be assigned in addition to the associated medical condition rather
than a diagnosis of developmental language disorder.
Other specified developmental speech or language disorder
Essential (required) features
• Persistent difficulties in understanding or producing speech or language or in using
language in context for the purposes of communication that are not better accounted
for by developmental speech sound disorder, developmental speech fluency disorder,
developmental language disorder or autism spectrum disorder are required for diagnosis.
• The speech or language difficulties are persistent over time.
• The onset of the speech or language difficulties occurs during the developmental period,
and speech or language abilities in the affected areas are markedly below what would be
expected based on age.
• The speech or language difficulties result in significant impairment in social communication,
or in personal, family, social, educational, occupational or other important areas of
functioning.
• The speech or language difficulties are not better accounted for by a disorder of intellectual
development, a disease of the nervous system, a sensory impairment or a structural
abnormality.
Developmental speech or language disorder, unspecified
6A01.Y
6A01.Z
Neurodevelopmental disorders | Developmental speech and language disorders

04 - 6A02 Autism spectrum disorder
6A02 Autism spectrum disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Autism spectrum disorder
Essential (required) features
• Persistent deficits in initiating and sustaining social communication and reciprocal social
interactions that are outside the expected range of typical functioning based on the
individual’s age and level of intellectual development are required for diagnosis. Specific
manifestations of these deficits vary according to chronological age, verbal and intellectual
ability, and disorder severity. Manifestations may include limitations in the following:
• understanding of, interest in, or inappropriate responses to the verbal or nonverbal social
communications of others;
• integration of spoken language with typical complimentary nonverbal cues, such as eye
contact, gestures, facial expressions and body language (these nonverbal behaviours may
also be reduced in frequency or intensity);
• understanding and use of language in social contexts and ability to initiate and sustain
reciprocal social conversations;
• social awareness, leading to behaviour that is not appropriately modulated according to
the social context;
• ability to imagine and respond to the feelings, emotional states and attitudes of others;
• mutual sharing of interests;
• ability to make and sustain typical peer relationships.
• Persistent restricted, repetitive and inflexible patterns of behaviour, interests or activities
that are clearly atypical or excessive for the individual’s age and sociocultural context are
an essential component. These may include:
• lack of adaptability to new experiences and circumstances, with associated distress, that
can be evoked by trivial changes to a familiar environment or in response to unanticipated
events;
• inflexible adherence to particular routines – for example, these may be geographical, such
as following familiar routes, or may require precise timing such as mealtimes or transport;
• excessive adherence to rules (e.g. when playing games);
• excessive and persistent ritualized patterns of behaviour (e.g. preoccupation with lining
up or sorting objects in a particular way) that serve no apparent external purpose;
• repetitive and stereotyped motor movements such as whole-body movements (e.g.
rocking), atypical gait (e.g. walking on tiptoes), unusual hand or finger movements and
posturing (these behaviours are particularly common during early childhood);
• persistent preoccupation with one or more special interests, parts of objects or specific
types of stimuli (including media), or an unusually strong attachment to particular objects
(excluding typical comforters);
• lifelong excessive and persistent hypersensitivity or hyposensitivity to sensory stimuli or
unusual interest in a sensory stimulus, which may include actual or anticipated sounds,
light, textures (especially clothing and food), odours and tastes, heat, cold or pain.
• The onset of the disorder occurs during the developmental period – typically in early
childhood – but characteristic symptoms may not become fully manifest until later, when
social demands exceed limited capacities.
6A02
Neurodevelopmental disorders | Autism spectrum disorder
125
Neurodevelopmental disorders
• The symptoms result in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning. Some individuals with autism
spectrum disorder are able to function adequately in many contexts through exceptional
effort, such that their deficits may not be apparent to others. A diagnosis of autism spectrum
disorder is still appropriate in such cases.
Specifiers for characterizing features within the autism spectrum
These specifiers enable the identification of co-occurring limitations in intellectual and functional
language abilities, which are important factors in the appropriate individualization of support,
selection of interventions and treatment planning for individuals with autism spectrum disorder. A
specifier is also provided for loss of previously acquired skills, which is a feature of the developmental
history of a small proportion of individuals with autism spectrum disorder.
Co-occurring disorder of intellectual development
Individuals with autism spectrum disorder may exhibit limitations in intellectual abilities. If present,
a separate diagnosis of disorder of intellectual development should be assigned, using the appropriate
category to designate severity (i.e. mild, moderate, severe, profound, provisional). Because social
deficits are a core feature of autism spectrum disorder, the assessment of adaptive behaviour as a part
of the diagnosis of a co-occurring disorder of intellectual development should place greater emphasis
on the intellectual, conceptual and practical domains of adaptive functioning than on social skills.
If no co-occurring diagnosis of disorder of intellectual development is present, the following specifier
for the autism spectrum disorder diagnosis should be applied:
• without disorder of intellectual development.
If there is a co-occurring diagnosis of disorder of intellectual development, the following specifier for
the autism spectrum disorder diagnosis should be applied, in addition to the appropriate diagnostic
code for the co-occurring disorder of intellectual development:
• with disorder of intellectual development.
Degree of functional language impairment
The degree of impairment in functional language (spoken or signed) should be designated with a
second specifier. Functional language refers to the capacity of the individual to use language for
instrumental purposes (e.g. to express personal needs and desires). This specifier is intended to
reflect primarily the verbal and nonverbal expressive language deficits present in some individuals
with autism spectrum disorder, and not the pragmatic language deficits that are a core feature of
autism spectrum disorder.
Neurodevelopmental disorders | Autism spectrum disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
The following specifiers should be applied to indicate the extent of functional language impairment
(spoken or signed) relative to the individual’s age:
• with mild or no impairment of functional language
• with impaired functional language (i.e. not able to use more than single words or simple
phrases)
• with complete, or almost complete, absence of functional language.
Table 6.5 shows the diagnostic codes corresponding to the categories that result from the application
of the specifiers for co-occurring disorder of intellectual development and degree of functional
language impairment.
Table 6.5. Diagnostic codes for autism spectrum disorder
With mild or no
impairment of
functional language
With impaired
functional language
With complete, or
almost complete,
absence of functional
language
Without disorder of
intellectual development
6A02.0
6A02.2
With disorder of intellectual
development
6A02.1
6A02.3
6A02.5
6A02.Y Other specified autism spectrum disorder can be used if the above parameters do not
apply.
6A02.Z Autism spectrum disorder, unspecified, can be used if the above parameters are unknown.
Loss of previously acquired skills
A small proportion of individuals with autism spectrum disorder may present with a loss of
previously acquired skills. This regression typically occurs during the second year of life and most
often involves language use and social responsiveness. Loss of previously acquired skills is rarely
observed after 3 years of age. If it occurs after age 3, it is more likely to involve loss of cognitive and
adaptive skills (e.g. loss of bowel and bladder control, impaired sleep), regression of language and
social abilities, and increasing emotional and behavioural disturbances.
There are two alternative specifiers to denote whether or not loss of previously acquired skills is an
aspect of the clinical history, where x corresponds to the final digit shown in Table 6.5:
• 6A02.x0 without loss of previously acquired skills
• 6A02.x1 with loss of previously acquired skills.
Neurodevelopmental disorders | Autism spectrum disorder
127
Neurodevelopmental disorders
Additional clinical features
• Common symptom presentations of autism spectrum disorder in young children are
parental or caregiver concerns about intellectual or other developmental delays (e.g.
problems in language and motor coordination). When there is no significant impairment
of intellectual functioning, clinical services may only be sought later (e.g. due to behaviour
or social problems when starting school). In middle childhood, there may be prominent
symptoms of anxiety, including social anxiety disorder, school refusal and specific phobia.
During adolescence and adulthood, depressive disorders are often a presenting feature.
• Co-occurrence of autism spectrum disorder with other mental, behavioural and
neurodevelopmental disorders is common across the lifespan. In a substantial proportion
of cases – particularly in adolescence and adulthood – it is a co-occurring disorder that
first brings an individual with autism spectrum disorder to clinical attention.
• Pragmatic language difficulties may manifest as an overly literal understanding of others’
speech, speech that lacks normal prosody and emotional tone and therefore appears
monotonous, lack of awareness of the appropriateness of their choice of language in
particular social contexts, or pedantic precision in the use of language.
• Social naivety, especially during adolescence, can lead to exploitation by others – a risk that
may be enhanced by the use of social media without adequate supervision.
• Profiles of specific cognitive skills in autism spectrum disorder as measured by standardized
assessments may show striking and unusual patterns of strengths and weaknesses that
are highly variable from individual to individual. These deficits can affect learning and
adaptive functioning to a greater extent than would be predicted from the overall scores
on measures of verbal and nonverbal intelligence.
• Self-injurious behaviours (e.g. hitting one’s face, head banging) occur more often in
individuals with co-occurring disorder of intellectual development.
• Some young individuals with autism spectrum disorder – especially those with a cooccurring disorder of intellectual development – develop epilepsy or seizures during
early childhood with a second increase in prevalence during adolescence. Catatonic states
have also been described. A number of medical disorders such as tuberous sclerosis,
chromosomal abnormalities including fragile X syndrome, cerebral palsy, early-onset
epileptic encephalopathies and neurofibromatosis are associated with autism spectrum
disorder with or without a co-occurring disorder of intellectual development. Genomic
deletions, duplications and other genetic abnormalities are increasingly described in
individuals with autism spectrum disorder, some of which may be important for genetic
counselling. Prenatal exposure to valproate is also associated with an increased risk of
autism spectrum disorder.
• Some individuals with autism spectrum disorder are capable of functioning adequately
by making an exceptional effort to compensate for their symptoms during childhood,
adolescence or adulthood. Such sustained effort, which may be more typical of affected
females, can have a deleterious impact on mental health and well-being.
Neurodevelopmental disorders | Autism spectrum disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
Social interaction skills
Typically developing individuals vary in the pace and extent to which they acquire and master skills
of reciprocal social interaction and social communication. A diagnosis of autism spectrum disorder
should only be considered if there is marked and persistent deviation from the expected range of
abilities and behaviours in these domains given the individual’s age, level of intellectual functioning
and sociocultural context. Some individuals may exhibit limited social interaction due to shyness
(i.e. feelings of awkwardness or fear in new situations or with unfamiliar people) or behavioural
inhibition (i.e. being slow to approach or to “warm up” to new people and situations). Limited social
interactions in shy or behaviourally inhibited children, adolescents or adults are not indicative of
autism spectrum disorder. Shyness is differentiated from autism spectrum disorder by evidence of
adequate social communication behaviours in familiar situations.
Social communication skills
Children vary widely in the age at which they first acquire spoken language and the pace at which
their speech and language become firmly established. Most children with early language delay
eventually acquire similar language skills to those of their same-age peers. Early language delay
alone is not strongly indicative of autism spectrum disorder unless there is also evidence of
limited motivation for social communication and limited interaction skills. An essential feature of
autism spectrum disorder is persistent impairment in the ability to understand and use language
appropriately for social communication.
Repetitive and stereotyped behaviours
Many children go through phases of repetitive play and highly focused interests as a part of typical
development. Unless there is also evidence of impaired reciprocal social interaction and social
communication, patterns of behaviour characterized by repetition, routine or restricted interests
are not by themselves indicative of autism spectrum disorder.
Course features
• Although autism spectrum disorder can present clinically at all ages, including during
adulthood, it is a lifelong disorder, the manifestations and impact of which are likely to
vary according to age, intellectual and language abilities, co-occurring conditions and
environmental context.
• Restricted and repetitive behaviours persist over time. Specifically, repetitive sensorimotor
behaviours appear to be common, consistent and potentially severe. During the schoolage years and adolescence, these repetitive sensorimotor behaviours begin to lessen in
intensity and number. Insistence on sameness, which is less prevalent, appears to develop
during preschool and worsen over time.
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Neurodevelopmental disorders
Developmental presentations
Infancy
Characteristic features may emerge during infancy, although they may only be recognized as
indicative of autism spectrum disorder in retrospect. It is usually possible to make the diagnosis of
autism spectrum disorder during the preschool period (up to 4 years of age), especially in children
exhibiting generalized developmental delay. Plateauing of social communication and language skills
and failure to progress in their development is not uncommon. The loss of early words and social
responsiveness – i.e. a true regression – with an onset between 1 and 2 years of age is unusual but
significant, and rarely occurs after the third year of life. In these cases, the with loss of previously
acquired skills specifier should be applied.
Preschool
In preschool-aged children, indicators of an autism spectrum disorder diagnosis often include
avoidance of mutual eye contact, resistance to physical affection, a lack of social imaginary play,
language that is delayed in onset or is precocious but not used for social conversation; social
withdrawal, obsessive or repetitive preoccupations, and a lack of social interaction with peers
characterized by parallel play or disinterest. Sensory sensitivities to everyday sounds, or to foods,
may overshadow the underlying social communication deficits.
Middle childhood
In children with autism spectrum disorder without a disorder of intellectual development, social
adjustment difficulties outside the home may not be detected until middle childhood (commonly at
school entry) or during adolescence, when social communication problems lead to social isolation
from peers. Resistance to engage in unfamiliar experiences and marked reactions to even minor
change in routines are typical. Furthermore, excessive focus on detail and rigidity of behaviour and
thinking may be significant. Symptoms of anxiety may become evident at this stage of development.
Adolescence
By adolescence, the capacity to cope with increasing social complexity in peer relationships at a time
of increasingly demanding academic expectations is often overwhelmed. In some individuals with
autism spectrum disorder, the underlying social communication deficits may be overshadowed by
the symptoms of co-occurring mental and behavioural disorders. Depressive symptoms are often
a presenting feature.
Adulthood
In adulthood, the capacity for those with autism spectrum disorder to cope with social relationships
can become increasingly challenged, and clinical presentation may occur when social demands
overwhelm the capacity to compensate. Presenting problems in adulthood may represent reactions
to social isolation or the social consequences of inappropriate behaviour. Compensation strategies
may be sufficient to sustain dyadic relationships, but are usually inadequate in social groups. Special
interests, and focused attention, may benefit some individuals in education and employment.
Work environments may have to be tailored to the capacities of the individual. A first diagnosis
in adulthood may be precipitated by a breakdown in domestic or work relationships. In autism
spectrum disorder there is always a history of early childhood social communication and relationship
difficulties, although this may only be apparent in retrospect.
Neurodevelopmental disorders | Autism spectrum disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Culture-related features
• Cultural variation exists in norms of social communication and reciprocal social
interactions, as well as interests and activities. Therefore, signs of impairment in
functioning may differ depending on cultural context. For example, in some societies it
may be normative for children may avoid direct eye contact out of deference, which should
not be misinterpreted as impairment in social interaction.
Sex- and/or gender-related features
• Males are four times more likely than females to be diagnosed with autism spectrum disorder.
• Females diagnosed with autism spectrum disorder are more frequently diagnosed with
co-occurring disorders of intellectual development than males, suggesting that less severe
presentations may go undetected. Females tend to demonstrate fewer restricted, repetitive
interests and behaviours.
• During middle childhood, gender differences in presentation differentially affect
functioning. Boys may act out with reactive aggression or other behavioural symptoms
when challenged or frustrated. Girls tend to withdraw socially, and react with emotional
changes to their social adjustment difficulties.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with disorders of intellectual development
Autism spectrum disorder may be diagnosed in individuals with disorders of intellectual
development if deficits in initiating and sustaining social communication and reciprocal social
interactions are greater than would be expected based on the individual’s level of intellectual
functioning, and if the other diagnostic requirements for autism spectrum disorder are also met.
In these circumstances, both autism spectrum disorder and the disorder of intellectual development
should be assigned, and the with disorder of intellectual development specifier should be applied with
the autism spectrum disorder diagnosis. Because autism spectrum disorder inherently involves
social deficits, assessment of adaptive behaviour as a part of the diagnosis of a co-occurring disorder
of intellectual development should place greater emphasis on intellectual functioning and the
conceptual and practical domains of adaptive functioning than on social skills. The diagnosis
of autism spectrum disorder in individuals with severe and profound disorders of intellectual
development is particularly difficult, and requires in-depth and longitudinal assessments. However,
the diagnosis may be assigned if skills in social reciprocity and communication are significantly
impaired relative to the individual’s general level of intellectual ability.
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Neurodevelopmental disorders
Boundary with developmental language disorder with impairment of mainly
pragmatic language
Individuals with developmental language disorder with impairment of mainly pragmatic language
exhibit language deficits involving the ability to understand and use language in social contexts (i.e.
with pragmatic language impairment). Unlike individuals with autism spectrum disorder, individuals
with developmental language disorder are usually able to initiate and respond appropriately to
social and emotional cues and to share interests with others, and do not typically exhibit restricted,
repetitive and stereotyped behaviours. An additional diagnosis of developmental language disorder
should not be assigned to individuals with autism spectrum disorder based solely on pragmatic
language impairment. The other forms of developmental language disorder (i.e. with impairment
of receptive and expressive language or with impairment of receptive and expressive language) may
be assigned in conjunction with a diagnosis of autism spectrum disorder if language abilities are
markedly below what would be expected based on age and level of intellectual functioning.
Boundary with developmental motor coordination disorder
Individuals with autism spectrum disorder may be reluctant to participate in tasks requiring
complex motor coordination skills, such as ball sports, which is better accounted for by a lack of
interest rather than any specific deficits in motor coordination. However, developmental motor
coordination disorder and autism spectrum disorder can co-occur, and both diagnoses may be
assigned if warranted.
Boundary with attention deficit hyperactivity disorder
Specific abnormalities in attention (e.g. being overly focused or easily distracted), impulsivity
and physical hyperactivity are often observed in individuals with autism spectrum disorder.
However, individuals with attention deficit hyperactivity disorder do not exhibit the persistent
deficits in initiating and sustaining social communication and reciprocal social interactions or
the persistent restricted, repetitive and inflexible patterns of behaviour, interests or activities that
are the defining features of autism spectrum disorder. However, autism spectrum disorder and
attention deficit hyperactivity disorder can co-occur, and both diagnoses may be assigned if the
diagnostic requirements for each are met. Attention deficit hyperactivity disorder symptoms may
sometimes dominate the clinical presentation such that some autism spectrum disorder symptoms
are less apparent.
Boundary with stereotyped movement disorder
Stereotyped movement disorder is characterized by voluntary, repetitive, stereotyped, apparently
purposeless (and often rhythmic) movements that arise during the early developmental period.
Although such stereotyped movements are typical in autism spectrum disorder, if they are severe
enough to require additional clinical attention – for example, because of self-injury – a co-occurring
diagnosis of stereotyped movement disorder may be warranted.
Boundary with schizophrenia
The onset of schizophrenia may be associated with prominent social withdrawal, which is either
preceded by or results in social impairments that may resemble social deficits seen in autism
spectrum disorder. However, unlike autism spectrum disorder, the onset of schizophrenia is
typically in adolescence or early adulthood, and is extremely rare prior to puberty. Schizophrenia
is differentiated on the basis of the presence of psychotic symptoms (e.g. delusions, hallucinations),
as well as a lack of restricted, repetitive and inflexible patterns of behaviour, interests or activities
during early childhood typical of autism spectrum disorder.
Boundary with schizotypal disorder
Interpersonal difficulties seen in autism spectrum disorder may share some features of schizotypal
disorder, such as poor rapport with others and social withdrawal. However, autism spectrum
disorder is also characterized by restricted, repetitive and stereotyped patterns of behaviour, interests
or activities.
Neurodevelopmental disorders | Autism spectrum disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with social anxiety disorder
Social anxiety disorder is associated with limited engagement in social interaction due to marked
and excessive fear or anxiety about negatively evaluated by others. Typically, when interacting with
familiar others or in social situations that do not provoke significant anxiety, there is no evidence
of impairment. Individuals with autism spectrum disorder may experience social anxiety, but
they also exhibit more pervasive deficits in initiating and sustaining social communication and
reciprocal social interactions than are typically observed in social anxiety disorder. Persistent
restricted, repetitive and inflexible patterns of behaviour, interests or activities are not features of
social anxiety disorder.
Boundary with selective mutism
Selective mutism is characterized by normal use of language and patterns of social communication in
specific environments (such as the home), but not in others (such as at school). In autism spectrum
disorder, a reluctance to communicate may be observed in some social circumstances, but deficits
in initiating and sustaining social communication and reciprocal social interactions and persistent
restricted, repetitive and inflexible patterns of behaviour, interests or activities are evident across
all situations and contexts.
Boundary with obsessive-compulsive disorder
Obsessive-compulsive disorder is characterized by persistent repetitive thoughts, images, or
impulses/urges (i.e. obsessions) and/or repetitive behaviours (i.e. compulsions) that the individual
feels driven to perform in response to an obsession, according to rigid rules, to reduce anxiety or to
achieve a sense of “completeness”. These symptoms may be difficult to distinguish from restricted,
repetitive and inflexible patterns of behaviour, interests or activities that are characteristic of autism
spectrum disorder. Unlike those with autism spectrum disorder, it is more common for individuals
with obsessive-compulsive disorder consciously to resist their impulsive urges to perform compulsive
behaviours (e.g. by performing alternate tasks), though adolescents and adults with autism spectrum
disorder may also try to suppress specific behaviours that they realize are socially undesirable.
Autism spectrum disorder can also be distinguished from obsessive-compulsive disorder by its
characteristic deficits in initiating and sustaining social communication and reciprocal social
interactions, which are not features of obsessive-compulsive disorder.
Boundary with reactive attachment disorder
Reactive attachment disorder is characterized by inhibited emotionally withdrawn behaviour
exhibited towards adult caregivers, including a failure to approach a discriminated, preferred
attachment figure for comfort, support, protection or nurturance. The diagnosis of reactive
attachment disorder requires evidence of a history of severe neglect or maltreatment by the primary
caregiver or other forms of severe social deprivation (e.g. certain types of institutionalization). Some
individuals reared under conditions of severe deprivation in institutional settings exhibit autistic-like
features, including difficulties in social reciprocity and restricted, repetitive and inflexible patterns
of behaviour, interests or activities. Also referred to as “quasi-autism”, affected individuals are
differentiated from those with autism spectrum disorder based on significant improvement of
autism-like features when the child is moved to a more nurturing environment. Differentiation
between reactive attachment disorder and autism spectrum disorder is difficult when no reliable
evidence is available of intact social and communicative development prior to the onset of abuse
or neglect.
Boundary with disinhibited social engagement disorder
Disinhibited social engagement disorder is characterized by persistent indiscriminate social
approaches to unfamiliar adults and peers, a pattern of behaviour that may also be seen in some
children with autism spectrum disorder. The diagnosis of disinhibited social engagement disorder
requires evidence of a history of severe neglect or maltreatment by the primary caregiver or other
forms of severe social deprivation (e.g. certain types of institutionalization). As in reactive attachment
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133
Neurodevelopmental disorders
disorder, disinhibited social engagement disorder may be associated with generalized deficits in
social understanding and social communication. Although they may occur, restricted, repetitive
and inflexible patterns of behaviour, interests or activities are not typical features of disinhibited
social engagement disorder. Evidence of a significant reduction in symptoms when the child is
provided a more nurturing environment suggests that disinhibited social engagement disorder is
the appropriate diagnosis.
Boundary with avoidant-restrictive food intake disorder
Individuals with avoidant-restrictive food intake disorder sometimes restrict their food intake
based on food’s sensory characteristics such as smell, taste, temperature, texture or appearance.
Individuals with autism spectrum disorder may also restrict intake of certain foods because of their
sensory characteristics or because of inflexible adherence to particular routines. However, autism
spectrum disorder is also characterized by persistent deficits in initiating and sustaining social
communication and reciprocal social interactions and persistent restricted, repetitive and inflexible
patterns of behaviour, interests or activities that are unrelated to food. If a pattern of restricted eating
in an individual with autism spectrum disorder has caused significant weight loss or other health
consequences, or is specifically associated with significant functional impairment, an additional
diagnosis of avoidant-restrictive food intake disorder may be assigned.
Boundary with oppositional defiant disorder
Oppositional defiant disorder is characterized by a pattern of markedly noncompliant, defiant
and disobedient disruptive behaviour that is not typical for individuals of comparable age and
developmental level. Individuals with oppositional defiant disorder do not exhibit the social
communication deficits or restricted, repetitive and inflexible patterns of behaviour, interests or
activities that are characteristic of autism spectrum disorder. However, oppositional or “demand
avoidant” behaviour may be prominent in some children with autism spectrum disorder, whether or
not they have accompanying intellectual or functional language impairments, and may sometimes be
the presenting feature in school-aged children with autism spectrum disorder. Disruptive behaviour
with aggressive outbursts (explosive rages) may also be a prominent feature of autism spectrum
disorder. Among individuals with autism spectrum disorder, such outbursts are often associated
with a specific trigger (e.g. a change in routine, aversive sensory stimulation, anxiety or rigidity
when the individual’s thoughts or behaviour sequences are interrupted) rather than reflecting an
intention to be defiant, provocative or spiteful, as is more typical of oppositional defiant disorder.
Boundary with personality disorder
Personality disorder is a pervasive disturbance in how an individual experiences and thinks about the
self, others and the world, manifested in maladaptive patterns of cognition, emotional experience,
emotional expression and behaviour. The maladaptive patterns are relatively inflexible, manifesting
across a range of personal and social situations; relatively stable over time; and of long duration. They
are associated with significant problems in psychosocial functioning that are particularly evident in
interpersonal relationships. The difficulties some individuals with autism spectrum disorder exhibit
in initiating and maintaining relationships because of their limited skills in social communication
and reciprocal social interactions may resemble those seen in some individuals with personality
disorder. However, unlike autism spectrum disorder, persistent restricted, repetitive and inflexible
patterns of behaviour, interests or activities with onset in early childhood are not characteristic
features of personality disorder.
Boundary with primary tics and tic disorders including Tourette syndrome
Sudden, rapid, non-rhythmic and recurrent movements or vocalizations occur in primary tics and
tic disorders, which may resemble repetitive and stereotyped motor movements in autism spectrum
disorder. Unlike autism spectrum disorder, tics in primary tics and tic disorders tend to be less
stereotyped, are often accompanied by premonitory sensory urges, last for a shorter period, tend
to emerge later in life, and are not experienced by the individual as soothing.
Neurodevelopmental disorders | Autism spectrum disorder

05 - 6A03 Developmental learning disorder
6A03 Developmental learning disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with diseases of the nervous system and other medical conditions
classified elsewhere
Loss of previously acquired skills in language and social communication in the second year of life
is reported in some children with autism spectrum disorder, but this rarely occurs after the age of
3 years. Diseases of the nervous system and other medical conditions associated with regression
(e.g. acquired epileptic aphasia or Landau-Kleffner syndrome, autoimmune encephalitis, Rett
syndrome) are differentiated from autism spectrum disorder with loss of previously acquired skills
on the basis of an early history of relatively normal social and language development, and by the
characteristic neurological features of these disorders that are not typical of autism spectrum disorder.
Boundary with secondary neurodevelopmental syndrome
Autistic features may become manifest in the context of acquired medical conditions, such as
encephalitis. Identifying accurately whether the symptoms are secondary to another medical
condition or represent the exacerbation of pre-existing autism spectrum disorder may have
implications for both immediate management and prognosis. When autistic symptoms are
attributable to another medical condition, a diagnosis of secondary neurodevelopmental syndrome
rather than autism spectrum disorder may be assigned.
Developmental learning disorder
Essential (required) features
• The presence of significant limitations in learning academic skills of reading, writing or
arithmetic, resulting in a skill level markedly below what would be expected based on age is
required for diagnosis. Limitations in learning are manifest, despite appropriate academic
instruction in the relevant areas. The limitations may be restricted to a single component of
a skill (e.g. an inability to master basic numeracy, or to decode single words accurately and
fluently) or may affect all reading, writing and arithmetic. Ideally, limitations are measured
using appropriately normed and standardized tests.
• Onset of the limitations typically occurs during the early school years, but in some
individuals may not be identified until later in life, including into adulthood, when
performance demands related to learning exceed limited capacities.
• The limitations are not attributable to external factors, such as economic or environmental
disadvantage, or lack of access to educational opportunities.
• The learning difficulties are not better accounted for by a disorder of intellectual
development or another neurodevelopmental disorder, or by another condition such as a
motor disorder or a sensory disorder of vision or hearing.
• The learning difficulties result in significant impairment in the individual’s academic,
occupational or other important areas of functioning. If functioning is maintained, it is
only through significant additional effort.
6A03
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135
Neurodevelopmental disorders
Specifiers for area of learning impairment
Specifiers should be applied to indicate which academic skills are significantly impaired at the
time of assessment. Multiple specifiers may be used to reflect limitations in multiple skills.
Impairment in reading
• Learning difficulties are manifested in impairments in reading skills such as word reading
accuracy, reading fluency or reading comprehension.
Impairment in written expression
• Learning difficulties are manifested in impairments in writing skills such as spelling
accuracy, grammar and punctuation accuracy, or organization and cohesion of ideas
in writing.
Impairment in mathematics
• Learning difficulties are manifested in impairments in mathematical skills such as number
sense, memorization of number facts, accurate calculation, fluent calculation or accurate
mathematic reasoning.
Other specified impairment of learning
• Learning difficulties are manifested in impairments in learning and performance of
specific academic skills that are not adequately characterized by one of the other available
specifiers.
Developmental learning disorder, unspecified
6A03.0
6A03.1
6A03.2
6A03.3
6A03.Z
Neurodevelopmental disorders | Developmental learning disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Individuals with developmental learning disorder typically show impairments in
various underlying psychological processes that may include phonological processing,
orthographic processing, memory (including working memory), executive functions
(including inhibitory control, set-shifting, planning), learning and automatizing symbols
(e.g. visual, alphanumeric), perceptual-motor integration and speed of processing
information. Deficits in these psychological processes are presumed to underlie a child’s
ability to learn academic skills. However, the precise relationship between psychological
processes and outcomes related to learning capacity is not yet sufficiently understood to
allow an accurate and clinically useful classification based on these underlying processes.
• Developmental learning disorder commonly co-occurs with other neurodevelopmental
disorders, such as attention deficit hyperactivity disorder, developmental motor
coordination disorder, developmental language disorder and autism spectrum disorder.
• Many individuals with developmental learning disorder have marked difficulties selfregulating attention that are not sufficiently severe to warrant a separate diagnosis.
Persistent difficulties with self-regulated attention can have deleterious effects on academic
outcomes, and may impede response to intervention or support.
• Some individuals with developmental learning disorder may be able to sustain seemingly
adequate levels of key academic skills by using compensatory strategies or through
devoting extraordinarily high levels of effort or time, or through the provision of unusually
high levels of support. However, as demands for efficiency in key academic skills increase
and exceed capabilities (e.g. in timed tests, reading or writing lengthy detailed reports
for a tight deadline, heavier academic coursework as in high school/secondary school,
postsecondary education or professional training), the underlying learning difficulties
tend to become more fully apparent.
• Ideally, determination of the presence of developmental learning disorder includes
assessment of academic achievement using standardized, appropriately normed
instruments. However, a child’s score on a single test measuring a particular academic skill
is not sufficient to distinguish disorder from normality. Achievement scores may vary as a
result of the technical properties of the specific test being used, the testing conditions and a
variety of other variables, and also can vary substantially over the individual’s development
and life-course. Therefore, the diagnosis of developmental learning disorder should also
consider various sources of evidence regarding the child’s capacity for learning outside the
formal testing situation.
Boundary with normality (threshold)
• The age of acquisition of academic skills varies, and later acquisition of a particular academic
skill compared to same-age peers does not necessarily indicate the presence of a disorder.
Developmental learning disorder is distinguished by persistent difficulty in learning the
particular academic skills over time in spite of adequate educational opportunities, and by
the severity of the impairment caused by the learning difficulty.
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137
Neurodevelopmental disorders
Course features
• Deficits in reading, mathematics and written expression identified in childhood typically
persist through adolescence and into adulthood. These deficits may negatively affect a
child’s academic achievement, increase the likelihood of school dropout, and contribute to
unemployment (or underemployment) in adulthood – particularly if left untreated. Along
with school dropout, significant co-occurring depressive symptoms increase the risk of
poor mental health outcomes, including suicide.
• The specific impairments associated with developmental learning disorder vary with
developmental stage and learning abilities, severity of deficits, complexity of tasks,
presence of co-occurring mental, behavioural and neurodevelopmental disorders, and the
availability of support.
• Developmental learning disorder is also associated with heightened risk of suicidal ideation
and suicide attempts across the lifespan.
Developmental presentations
• Developmental learning disorder is most often diagnosed during elementary school years
because difficulties in reading, mathematics and/or writing typically only become evident
when these topics are taught formally. Some individuals, however, may not be diagnosed
until later in development, including in adulthood. Premorbid impairments, such as in
language, counting or rhyming, or fine motor control tend to be evident in early childhood
prior to the diagnosis of developmental learning disorder.
• The prevalence of developmental learning disorder across all areas of impairment
(i.e. reading, written expression and mathematics) is estimated to affect between 5% and
15% of school-aged children. Prevalence among adults is unknown, but is estimated at
approximately 4%. The prevalence of developmental learning disorder for specific academic
areas among school-aged children is variable (reading is estimated at 5–17%; mathematics
at 6–7%; written expression at 7–15%).
• Children with developmental learning disorder frequently exhibit co-occurring symptoms
of depressive disorders, anxiety and fear-related disorders, and externalizing behaviour
disorders, which may make it more difficult to assess their learning impairments.
• Children with developmental learning disorder with impairment in one academic area are
more likely to have co-occurring impairments in other areas.
Culture-related features
• Developmental learning disorder with impairment in reading can be manifested differently
by language. For example, in English, the presentation involves inaccurate and slow reading
of single words. In other languages with more direct mapping between sounds and letters
(e.g. Spanish, German) and non-alphabetic languages (e.g. Chinese, Japanese), the typical
presentation is slow but accurate reading.
Neurodevelopmental disorders | Developmental learning disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Developmental learning disorder is more common among boys. Boys may be more likely
to be clinically referred because of greater prevalence of co-occurring attention deficit
hyperactivity disorder or problematic externalizing behaviours.
• Among community samples, the gender ratio of males to females ranges from 1.5:1 to 3:1.
This ratio appears greater in clinical samples (estimated at 6:1).
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with disorders of intellectual development
Individuals with disorders of intellectual development often present with limitations in academic
achievement by virtue of significant generalized deficits in intellectual functioning. It is therefore
difficult to establish the co-occurring presence of a developmental learning disorder in individuals
with a disorder of intellectual development. Developmental learning disorder should only
be diagnosed in the presence of a disorder of intellectual development when the limitations in
learning are significantly in excess of those usually expected for the individual’s level of intellectual
functioning.
Boundary with developmental language disorder
Persistent deficits in the acquisition, understanding, production or use of language in developmental
language disorder may lead to academic learning difficulties, especially in literacy – including word
reading and written output. If all diagnostic requirements for both developmental language disorder
and developmental learning disorder are met, both diagnoses may be assigned.
Boundary with attention deficit hyperactivity disorder
Many individuals with developmental learning disorder have marked difficulties in self-regulating
attention. However, unlike in attention deficit hyperactivity disorder, the limitations in acquisition
of academic skills in developmental learning disorder are not solely a function of a child’s ability to
sustain attention on academic tasks or modulate their activity level appropriately. The co-occurrence
of developmental learning disorder and attention deficit hyperactivity disorder is common, and
both disorders may be diagnosed if diagnostic requirements are met.
Boundary with sensory impairments
Developmental learning disorder must be differentiated from learning difficulties that arise because
of sensory impairments in vision or hearing. However, individuals with vision and hearing problems
for which appropriate accommodations have been made may also have co-occurring developmental
learning disorder.
Boundary with neurodegenerative diseases
Developmental learning disorder is distinguished from learning difficulties that occur after the
developmental period due to neurodegenerative diseases or to injury (e.g. traumatic brain injury)
by the fact that in the latter conditions there is a loss of previously acquired academic skills and
previous capacity for learning new skills.
Neurodevelopmental disorders | Developmental learning disorder

06 - 6A04 Developmental motor coordination disorde
6A04 Developmental motor coordination disorder
139
Neurodevelopmental disorders
Developmental motor coordination disorder
Essential (required) features
• Significant delay in the acquisition of gross or fine motor skills and impairment in the
execution of coordinated motor skills manifesting as clumsiness, slowness or inaccuracy
of motor performance is required for diagnosis.
• Coordinated motor skills are markedly below those expected on the basis of age.
• Onset of coordinated motor skill difficulties occurs during the developmental period, and
is typically apparent from early childhood.
• Coordinated motor skills difficulties cause significant and persistent limitations in
activities of daily living, schoolwork, vocation and leisure activities, or other important
areas of functioning.
• Difficulties with coordinated motor skills are not better accounted for by a disease of
the nervous system, disease of the musculoskeletal system or connective tissue, sensory
impairment or a disorder of intellectual development.
Additional clinical features
• Young children with developmental motor coordination disorder may be delayed in
achieving motor milestones (e.g. sitting, crawling, walking), although many achieve
typical early motor milestones. Acquisition of skills such as negotiating stairs, pedalling,
buttoning shirts, completing puzzles, tying shoes and using zippers may be delayed or
pose difficulties. Even when a given skill is achieved, movement execution may appear
awkward, slow or less precise than that of peers. Children may drop things, stumble, bump
into obstacles or fall more frequently than peers.
• Developmental motor coordination disorder may affect primarily gross motor functioning,
primarily fine motor functioning or both aspects of motor functioning.
• Manifestations of developmental motor coordination disorder typically persist into adult
life. Older children and adults with developmental motor coordination disorder may be
slow or inaccurate in a variety of activities requiring fine or gross motor skills, such as team
sports (especially ball sports), bicycling, handwriting, assembling models or other objects,
or drawing maps.
• Other neurodevelopmental disorders commonly co-occur with developmental motor
coordination disorder. In addition to disorders of intellectual development, attention deficit
hyperactivity disorder and autism spectrum disorder, this also includes developmental
speech sound disorder (particularly difficulties with articulation), developmental
language disorder and developmental learning disorder. Although the presence of other
neurodevelopmental disorders does not preclude the diagnosis of developmental motor
coordination disorder, these disorders may also interfere with the execution of activities
6A04
Neurodevelopmental disorders | Developmental motor coordination disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
of daily living, schoolwork, and vocational and leisure activities that require coordinated
motor skills. Co-occurrence therefore complicates assessment and requires clinical
judgement in attributing limitations in activities that require coordinated motor skills to a
specific diagnosis.
Boundary with normality (threshold)
• There is considerable variation in the age of acquisition of many motor skills and a lack of
stability of measurement in early childhood. Onset of developmental motor coordination
disorder typically occurs during the early developmental period, but differentiation from
typical development before the age of 4 years is difficult due to the variability in motor
development and skill acquisition throughout early childhood. Therefore, the diagnosis of
developmental motor coordination disorder is usually not made before the age of 5 years.
• Performance of motor skills should ideally be assessed using appropriately normed,
individually administered, culturally appropriate standardized tests of gross and fine
motor coordination, and should include evaluation of the impact of symptoms at home
and at school (or, in adults, in the workplace). Key features for assessment are persistence
of motor skill impairment over time, severity of impairment and pervasiveness of impact
on functioning.
• Developmental motor coordination disorder often co-occurs with other neurodevelopmental
disorders. Attention deficit hyperactivity disorder is most common (an estimated 50% of
cases). Developmental speech and language disorder, developmental learning disorder
(most often with impairments in reading and written expression) and autism spectrum
disorder also commonly co-occur with developmental motor coordination disorder.
Course features
• Though there may be improvement in symptoms over time, with some children
experiencing a complete remission of symptoms, the course of developmental motor
coordination disorder is typically chronic, persisting into adolescence and adulthood in
up to 50–70% of cases. The persistence of developmental motor coordination disorder into
adulthood often affects social and psychological functioning as well as physical health.
• The presence of other co-occurring neurodevelopmental disorders, such as attention
deficit hyperactivity disorder, may further complicate the course of developmental motor
coordination disorder. Individuals with co-occurring disorders typically experience more
impairment than individuals with a single diagnosis.
Neurodevelopmental disorders | Developmental motor coordination disorder
141
Neurodevelopmental disorders
Developmental presentations
• The prevalence of developmental motor coordination disorder is approximately 5–6% of
children aged 5–11 years, although up to 10% of children may have less severe difficulties
with motor skills that still affect academic and social functioning.
• The manifestation of developmental motor coordination disorder symptoms varies with
developmental stage.
Preschool
In preschool-aged children, delays in meeting one or more motor milestones (e.g. sitting,
crawling, walking) or in developing specific skills (e.g. climbing stairs, buttoning clothing,
tying shoes) may be evident.
Middle childhood
In middle childhood, symptoms may be evident in activities such as handwriting, playing
with a ball, or building puzzles or models.
Adolescence and adulthood
By adolescence and adulthood, difficulties in motor coordination may manifest in
attempts to master new skills, such as driving, using tools or note taking.
All developmental stages
Across all developmental stages, even once a skill is acquired, the execution of movements
tends to be more awkward and less precise than in typically developing peers.
• Children with developmental motor coordination disorder may also be at increased risk of
co-occurring disruptive behaviour problems, anxiety and depression. In addition, children
with developmental motor coordination disorder tend to report lower levels of self-efficacy
and competence in physical and social abilities, and are at heightened risk of becoming
overweight or obese compared to their typically developing peers.
Sex- and/or gender-related features
• Developmental motor coordination disorder more frequently affects boys, with a ratio of
boys to girls of between 2:1 and 7:1.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with disorders of intellectual development
Individuals with disorders of intellectual development may exhibit delays in acquisition and
impairment in the execution of coordinated motor skills, along with deficits in general intellectual
Neurodevelopmental disorders | Developmental motor coordination disorder

07 - 6A05 Attention deficit hyperactivity disorder
6A05 Attention deficit hyperactivity disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
functioning and adaptive behaviour. If the diagnostic requirements of a disorder of intellectual
development are met, and coordinated motor skills are significantly below what would be expected
based on level of intellectual functioning and adaptive behaviour, both diagnoses may be assigned.
Boundary with autism spectrum disorder
In autism spectrum disorder, there may be reluctance to participate in tasks requiring complex
motor coordination skills, such as ball sports, which is better accounted for by a lack of interest
rather than any specific deficits in motor coordination.
Boundary with attention deficit hyperactivity disorder
Co-occurrence of developmental motor coordination disorder and attention deficit hyperactivity
disorder is common. Both diagnoses may be assigned if the diagnostic requirements for each are
met. However, some individuals with attention deficit hyperactivity disorder may appear to be
clumsy (e.g. bumping into obstacles, knocking things over) due to distractibility and impulsivity.
Developmental motor coordination disorder should not be diagnosed in such cases.
Boundary with diseases of the nervous system, diseases of the musculoskeletal
system or connective tissue, and sensory impairment
Motor skills may be affected by diseases of the nervous system (e.g. cerebral palsy, muscular
dystrophy), diseases of the musculoskeletal system or connective tissue, sensory impairment
(especially severe visual impairment) or joint hypermobility, which are established by appropriate
physical and laboratory examination. A diagnosis of developmental motor coordination disorder
should not be assigned when the difficulties with motor coordination are solely attributable to one
of these conditions. Some children with developmental motor coordination disorder show atypical
motor activity (usually suppressed), such as choreiform movements of unsupported limbs or mirror
movements.5 These “overflow” movements are not considered diseases of the nervous system per
se, and do not exclude the diagnosis of developmental motor coordination disorder.
Boundary with effects of psychosocial deprivation
Extreme psychosocial deprivation in early childhood can produce impairments in motor functions.
Depending on the onset, level of severity and duration of the deprivation, motor functioning
may improve substantially after the child is moved to a more positive environment. However,
some deficits may persist even after a sustained period in an environment that provides adequate
stimulation for development, and a diagnosis of developmental motor coordination disorder may
be appropriate in such cases if all diagnostic requirements are met.
Attention deficit hyperactivity disorder
Essential (required) features
• A persistent pattern (e.g. over at least 6 months) of inattention symptoms and/or a
combination of hyperactivity and impulsivity symptoms that is outside the limits of normal
variation expected for age and level of intellectual development is required for diagnosis.
Symptoms vary according to chronological age and disorder severity.
Chorieform movements are involuntary, irregular and unpredictable movements that make it appear as if the affected person is
dancing, twisting, restless, clumsy or fidgety.
6A05
Neurodevelopmental disorders | Attention deficit hyperactivity disorder
143
Neurodevelopmental disorders
Inattention
Several symptoms of inattention that are persistent and sufficiently severe that they have
a direct negative impact on academic, occupational or social functioning are among the
essential components. Symptoms are typically from the following clusters:
• having difficulty sustaining attention on tasks that do not provide a high level of
stimulation or reward or require sustained mental effort; lacking attention to detail;
making careless mistakes in school or work assignments; not completing tasks;
• being easily distracted by extraneous stimuli or thoughts not related to the task at
hand; often seeming not to listen when spoken to directly; frequently appearing to be
daydreaming or to have their mind elsewhere;
• losing things; being forgetful in daily activities; having difficulty remembering to complete
upcoming daily tasks or activities; having difficulty planning, managing and organizing
schoolwork, tasks and other activities.
Note: inattention may not be evident when the individual is engaged in activities that
provide intense stimulation and frequent rewards.
Hyperactivity-impulsivity
Several symptoms of hyperactivity-impulsivity that are persistent and sufficiently severe
that they have a direct negative impact on academic, occupational or social functioning are
among the essential components. These tend to be most evident in structured situations
that require behavioural self-control. Symptoms are typically from the following clusters:
• showing excessive motor activity; leaving their seat when expected to sit still; often
running about; having difficulty sitting still without fidgeting (younger children);
displaying feelings of physical restlessness and a sense of discomfort with being quiet or
sitting still (adolescents and adults);
• having difficulty engaging in activities quietly; talking too much;
• blurting out answers in school or comments at work; having difficulty waiting their turn
in conversation, games or activities; interrupting or intruding on others’ conversations
or games;
• having a tendency to act in response to immediate stimuli without deliberation or
consideration of risks and consequences (e.g. engaging in behaviours with potential for
physical injury; impulsive decisions; reckless driving).
• Evidence of significant inattention and/or hyperactivity-impulsivity symptoms prior to age 12,
though some individuals may first come to clinical attention later in adolescence or as adults,
often when demands exceed the individual’s capacity to compensate for limitations.
• Manifestations of inattention and/or hyperactivity-impulsivity must be evident across multiple
situations or settings (e.g. home, school, work, with friends or relatives), but are likely to vary
according to the structure and demands of the setting.
• Symptoms are not better accounted for by another mental disorder (e.g. an anxiety or fear-related
disorder, a neurocognitive disorder such as delirium).
• Symptoms are not due to the effects of a substance (e.g. cocaine) or medication (e.g. bronchodilators,
thyroid replacement medication) on the central nervous system, including and withdrawal effects,
and are not due to a disease of the nervous system.
Neurodevelopmental disorders | Attention deficit hyperactivity disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Specifiers to describe predominant characteristics of
clinical presentation
• The characteristics of the current clinical presentation should be described using one of the
following specifiers, which are meant to assist in recording the main reason for the current
referral or services. Predominance of symptoms refers to the presence of several symptoms
of either an inattentive or hyperactive-impulsive nature, with few or no symptoms of the
other type.
Attention deficit hyperactivity disorder, predominantly inattentive
presentation
• All diagnostic requirements for attention deficit hyperactivity disorder are met, and
inattentive symptoms predominate.
Attention deficit hyperactivity disorder, predominantly hyperactiveimpulsive presentation
• All diagnostic requirements for attention deficit hyperactivity disorder are met, and symptoms
of hyperactivity-impulsivity predominate.
Attention deficit hyperactivity disorder, combined presentation
• All diagnostic requirements for attention deficit hyperactivity disorder are met, and both
hyperactive-impulsive and inattentive symptoms are clinically significant aspects of the
current clinical presentation, with neither clearly predominating.
Attention deficit hyperactivity disorder, other specified presentation
Attention deficit hyperactivity disorder, presentation unspecified
6A05.0
6A05.1
6A05.2
6A05.Y
6A05.Z
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145
Neurodevelopmental disorders
Additional clinical features
• Attention deficit hyperactivity disorder usually manifests in early or middle childhood.
In many cases, hyperactivity symptoms predominate in preschool and decrease with age,
such that they are no longer prominent beyond adolescence or may instead be reported as
feelings of physical restlessness. Attentional problems may be more commonly observed
beginning in later childhood, especially in school and among adults in occupational settings.
• The manifestations and severity of attention deficit hyperactivity disorder often vary
according to the characteristics and demands of the environment. Symptoms and behaviours
should be evaluated across multiple types of environments as a part of clinical assessment.
• Where available, teacher and parent reports should be obtained to establish the diagnosis
in children and adolescents. In adults, the report of a significant other, family member or
co-worker can provide important additional information.
• Some individuals with attention deficit hyperactivity disorder may first present for services
in adulthood. When making the diagnosis of attention deficit hyperactivity disorder in
adults, a history of inattention, hyperactivity or impulsivity before 12 years of age is an
important corroborating feature that can be best established from school or local records,
or from informants who knew the individual during childhood. In the absence of such
corroborating information, a diagnosis of attention deficit hyperactivity disorder in older
adolescents and adults should be made with caution.
• In a subset of individuals with attention deficit hyperactivity disorder, especially in
children, an exclusively inattentive presentation may occur. There is no hyperactivity, and
the presentation is characterized by daydreaming, mind-wandering and a lack of focus.
These children are sometimes referred to as exhibiting a “restrictive inattentive pattern of
symptoms” or “sluggish cognitive tempo”.
• In a subset of individuals with attention deficit hyperactivity disorder, combined
presentation, severe inattentiveness and hyperactivity-impulsivity are both consistently
present in most of the situations that an individual encounters, and are also evidenced by
the clinician’s own observations. This pattern is often referred to as “hyperkinetic disorder”,
and is considered a more severe form of the disorder.
• Attention deficit hyperactivity disorder symptoms often significantly limit academic
achievement. Adults with attention deficit hyperactivity disorder often find it difficult to
hold down a demanding job, and may be disproportionately underemployed or unemployed.
Attention deficit hyperactivity disorder can also strain interpersonal relationships across
the lifespan, including those with family members, peers and romantic partners. Individuals
with attention deficit hyperactivity disorder often have greater difficulty regulating their
behaviour in the context of groups than in one-on-one situations.
• Attention deficit hyperactivity disorder often co-occurs with other neurodevelopmental
disorders, including developmental speech and language disorders and primary tics and
tic disorders, which are classified in Chapter 8 on diseases of the nervous system but
cross-listed under neurodevelopment disorders. Attention deficit hyperactivity disorder is
associated with an increased risk of obsessive-compulsive disorder and gaming disorder,
and with elevated rates of epilepsy. Emotional dysregulation, low frustration tolerance
and subtle clumsiness and other minor (“soft”) neurological abnormalities in sensory and
motor performance in the absence of any identifiable brain pathology are also common in
attention deficit hyperactivity disorder.
Neurodevelopmental disorders | Attention deficit hyperactivity disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Attention deficit hyperactivity disorder is associated with an increased risk of physical
health problems including accidents.
• Acute onset of hyperactive behaviour in a school-aged child or adolescent should raise
the possibility that symptoms are better accounted for by another mental disorder or by a
medical condition. For example, abrupt onset of hyperactivity in adolescence or adulthood
may indicate an emergent primary psychotic or bipolar disorder.
• Although attention deficit hyperactivity disorder tends to run in families, with evidence
of high heritability, the predominant symptom pattern in attention deficit hyperactivity
disorder in a given individual often changes over time and cannot be predicted based on
the predominant symptoms of other family members.
Boundary with normality (threshold)
• Inattention, hyperactivity and impulsivity symptoms are present in many children,
adolescents and adults, especially during certain developmental periods (e.g. early
childhood). The diagnosis of attention deficit hyperactivity disorder requires that these
symptoms be persistent across time, pervasive across situations and significantly out
of keeping with developmental level, and have a direct negative impact on academic,
occupational or social functioning.
Course features
• Nearly half of all children diagnosed with attention deficit hyperactivity disorder will
continue to exhibit symptoms into adolescence. Predictors of persistence into adolescence
and adulthood include co-occurring childhood-onset mental, behavioural and
neurodevelopmental disorders, lower intellectual functioning, poorer social functioning
and behavioural problems.
• Attention deficit hyperactivity disorder symptoms tend to remain stable throughout
adolescence, with approximately one third of individuals diagnosed in childhood
continuing to experience impairment in adulthood.
• Although symptoms of hyperactivity become less overt during adolescence and adulthood,
individuals may still experience difficulties with inattention, impulsivity and restlessness.
Developmental presentations
• Adolescents and adults may only seek clinical services after 12 years of age, once symptoms
become more limiting with increasing social, emotional and academic demands or in the
context of an evolving co-occurring mental, behavioural or neurodevelopmental disorder
that results in an exacerbation of attention deficit hyperactivity disorder symptoms.
Neurodevelopmental disorders | Attention deficit hyperactivity disorder
147
Neurodevelopmental disorders
Culture-related features
• The symptoms of attention deficit hyperactivity disorder consistently fall into two separate
dimensions across cultures: inattention and hyperactivity-impulsivity. However, culture
can influence both acceptability of symptoms and how caregivers respond to them.
• The assessment of hyperactivity should take into account cultural norms of age and genderappropriate behaviour. For example, in some countries hyperactive behaviour may be seen
as a sign of strength in a boy (e.g. “boiling blood”) while being perceived very negatively
in a girl.
• Symptoms of inattention or hyperactivity-impulsivity may occur in response to exposure
to traumatic events and grief reactions during childhood, particularly in highly vulnerable
and disadvantaged populations, including in post-conflict areas. In these settings,
clinicians should consider whether the diagnosis of attention deficit hyperactivity disorder
is warranted.
Sex- and/or gender-related features
• Attention deficit hyperactivity disorder is more prevalent among males.
• Females are more likely to exhibit inattentive symptoms whereas males are more likely to
exhibit symptoms of hyperactivity and impulsivity, particularly at younger ages.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with disorders of intellectual development
Co-occurrence of attention deficit hyperactivity disorder and disorders of intellectual development
is common, and both diagnoses may be assigned if warranted. However, symptoms of inattention
and hyperactivity (e.g. restlessness) are common in children without attention deficit hyperactivity
disorder who are placed in academic settings that are out of keeping with their intellectual abilities.
A diagnosis of attention deficit hyperactivity disorder in individuals with disorders of intellectual
development requires that attention deficit hyperactivity disorder symptoms are disproportionate
to the individual’s level of intellectual functioning.
Boundary with autism spectrum disorder
Specific abnormalities in attention (e.g. being overly focused or easily distracted), impulsivity and
physical hyperactivity are often observed in individuals with autism spectrum disorder, and may
sometimes dominate the clinical presentation. Unlike individuals with autism spectrum disorder,
those with attention deficit hyperactivity disorder do not exhibit the persistent deficits in initiating
and sustaining social communication and reciprocal social interactions, or the persistent restricted,
repetitive and inflexible patterns of behaviour, interests or activities that are the defining features of
autism spectrum disorder. However, co-occurrence of these disorders is common.
Neurodevelopmental disorders | Attention deficit hyperactivity disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with developmental learning disorder
Individuals with developmental learning disorder without attention deficit hyperactivity disorder
may exhibit symptoms of inattention and hyperactivity when asked to focus on specific academic
activities that correspond to their areas of difficulty (i.e. reading, mathematics or writing). If difficulty
in sustaining attention on academic tasks or appropriately modulating activity level occurs only
in response to these tasks, and there is evidence of limitations in acquisition of academic skills in
the specific corresponding area, a diagnosis of developmental learning disorder and not attention
deficit hyperactivity disorder should be assigned.
Boundary with developmental motor coordination disorder
Co-occurrence of attention deficit hyperactivity disorder and developmental motor coordination
disorder is common, and both diagnoses may be assigned if warranted. However, apparent
clumsiness in some individuals with attention deficit hyperactivity disorder (e.g. bumping into
obstacles, knocking things over) that is due to distractibility and impulsivity should not be diagnosed
as developmental motor coordination disorder.
Boundary with mood disorders and anxiety and fear-related disorders
Attention deficit hyperactivity disorder can co-occur with mood disorders and anxiety and fearrelated disorders, but inattention, hyperactivity and impulsivity can also be features of these disorders
in individuals without attention deficit hyperactivity disorder. For example, symptoms such as
restlessness, pacing and impaired concentration can be features of a depressive episode, and should
not be considered as part of the diagnosis of attention deficit hyperactivity disorder unless they have
been present since childhood and persist after the resolution of the depressive episode. Inattention,
impulsivity and hyperactivity are typical features of manic and hypomanic episodes. At the same
time, mood lability and irritability may be associated features of attention deficit hyperactivity
disorder. Late adolescent or adult onset, episodicity and intensity of mood elevation characteristic
of bipolar disorders are features that assist in differentiation from attention deficit hyperactivity
disorder. Fidgeting, restlessness and tension in the context of anxiety and fear-related disorders may
resemble hyperactivity. Furthermore, anxious preoccupations or reaction to anxiety-provoking
stimuli in individuals with anxiety and fear-related disorders can be associated with difficulties
concentrating. To qualify for an attention deficit hyperactivity disorder diagnosis in the presence
of a mood disorder or an anxiety or fear-related disorder, inattention and/or hyperactivity should
not be exclusively associated with mood episodes, be solely attributable to anxious preoccupations,
or occur specifically in response to anxiety-provoking situations.
Boundary with intermittent explosive disorder
Attention deficit hyperactivity disorder and intermittent explosive disorder are both characterized
by impulsive behaviour. However, intermittent explosive disorder is specifically characterized by
intermittent severe impulsive outbursts or aggression rather than ongoing generalized behavioural
impulsivity that may be seen in attention deficit hyperactivity disorder.
Boundary with oppositional defiant disorder
Individuals with attention deficit hyperactivity disorder often have difficulty following instructions,
complying with rules and getting along with others, but these difficulties are primarily accounted
for by symptoms of inattention and/or hyperactivity and impulsivity (e.g. failure to follow long and
complicated instructions, difficulty remaining seated or staying on task). In contrast, noncompliance
in individuals with oppositional defiant disorder is characterized by deliberate defiance or
disobedience and not by problems with inattention or with controlling behavioural impulses or
inhibiting inappropriate behaviours. However, co-occurrence of these disorders is common.
Boundary with conduct-dissocial disorder
In adolescents and adults with attention deficit hyperactivity disorder, some behaviours that are
manifestations of impulsivity such as grabbing objects, reckless driving or impulsive decision-making
– such as suddenly walking out of jobs or relationships – may bring the individual in conflict with
Neurodevelopmental disorders | Attention deficit hyperactivity disorder

08 - 6A06 Stereotyped movement disorder
6A06 Stereotyped movement disorder
149
Neurodevelopmental disorders
other people and the law. In contrast, individuals with conduct-dissocial disorder typically lack
the symptoms of inattention and hyperactivity, and exhibit a repetitive and persistent pattern of
behaviour in which the basic rights of others or major age-appropriate societal norms, rules or laws
are violated. However, co-occurrence of these disorders is common.
Boundary with personality disorder
Individuals with attention deficit hyperactivity disorder often experience problems with psychosocial
functioning and interpersonal relationships, including regulation of emotions and negative
emotionality. If attention deficit hyperactivity disorder persists into adolescence and adulthood,
it may be difficult to distinguish from personality disorder with prominent personality features of
disinhibition, which includes irresponsibility, impulsivity, distractibility and recklessness, and from
negative affectivity, which refers to a habitual tendency to manifest a broad range of distressing
emotions including anxiety, anger, self-loathing, irritability and increased sensitivity to negative
stimuli. The utility of assigning an additional diagnosis of personality disorder in situations where
there is an established diagnosis of attention deficit hyperactivity disorder depends on the specific
clinical situation.
Boundary with disorders due to substance use and the effects of certain prescribed
medications
Abuse of alcohol, nicotine, cannabis and stimulants is common among individuals with attention
deficit hyperactivity disorder – particularly adolescents and adults. However, the effects of these
substances can also mimic the symptoms of attention deficit hyperactivity disorder in individuals
without the diagnosis. Symptoms of inattention, hyperactivity or impulsivity are also associated
with the effects of certain prescribed medications (e.g. anticonvulsants such as carbamazepine and
valproate, antipsychotics such as risperidone, and somatic treatments such as bronchodilators and
thyroid replacement medication). The temporal order of onset and the persistence of inattention,
hyperactivity and impulsivity in the absence of intoxication or continued medication use are
important in differentiating between attention deficit hyperactivity disorder and disorders due
to substance use or the effects of prescribed medications. A review of current medications and
informants who knew the individual before they started using the substances or medications in
question are critical in making this distinction.
Boundary with attentional symptoms due to other medical conditions
A variety of other medical conditions may influence attentional processes (e.g. hypoglycaemia,
hyperthyroidism or hypothyroidism, exposure to toxins, sleep-wake disorders), resulting in
temporary or persistent symptoms that resemble or interact with those of attention deficit
hyperactivity disorder. As a basis for appropriate management, it is important to evaluate in such
cases whether the symptoms are secondary to the medical condition or are more indicative of
comorbid attention deficit hyperactivity disorder.
Stereotyped movement disorder
Essential (required) features
• The persistent (e.g. lasting for several months) presence of voluntary, repetitive, stereotyped,
apparently purposeless and often rhythmic movements (e.g. body rocking, hand flapping,
head banging, eye poking and hand biting) that are not caused by the direct physiological
effects of a substance or medication (including withdrawal) is required for diagnosis.
6A06
Neurodevelopmental disorders | Stereotyped movement disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Stereotyped movements result in significant interference with the ability to engage in
normal daily activities, or result in self-inflicted bodily injury severe enough to be an
independent focus of clinical attention or that would result in self-injury if protective
measures were not taken.
• Onset occurs during the developmental period, typically at an early age.
Specifiers related to self-injury
A specifier should be applied with the diagnosis of stereotyped movement disorder to indicate
whether it involves movements that result in physical harm to the individual.
Stereotyped movement disorder without self-injury
• Stereotyped movements do not result in physical harm to the affected individual even
without the presence of protective measures. These behaviours typically include body
rocking, head rocking, finger-flicking mannerisms and hand flapping.
Stereotyped movement disorder with self-injury
• Stereotyped movements result in harm to the affected individual that is severe enough to
be an independent focus of clinical attention, or would result in self-injury if protective
measures (e.g. helmet to prevent head injury) were not taken. These behaviours typically
include head banging, face slapping, eye poking and biting of the hands, lips or other
body parts.
Stereotyped movement disorder, unspecified
Additional clinical features
• Co-occurrence of stereotyped movement disorder and disorders of intellectual development
is common.
6A06.0
6A06.1
6A06.Z
Neurodevelopmental disorders | Stereotyped movement disorder
151
Neurodevelopmental disorders
Boundary with normality (threshold)
• Many young children show stereotyped behaviours (e.g. thumb sucking). In older children
and adults, repetitive behaviours such as leg shaking, finger drumming/tapping or selfstimulatory behaviours (e.g. masturbation) may be seen in response to boredom. These
behaviours are differentiated from stereotyped movement disorder because they do not
result in significant interference with normal daily activities; nor do they result in selfinflicted bodily injury that is severe enough to be an independent focus of clinical attention.
Course features
• Among typically developing children, stereotyped movements remit over time (or become
suppressed). Among individuals with a disorder of intellectual development and autism
spectrum disorder with disorder of intellectual development, however, stereotyped (and
self-injurious) behaviours may persist, though the presentation of these behaviours may
change over time.
Developmental presentations
• Onset of stereotyped movement disorder occurs early in the developmental period, with
stereotyped movements often emerging before 3 years of age; up to 80% of children who
exhibit complex motor stereotyped movements display them before 2 years of age.
• Stereotyped movements are common in typically developing children, and often resolve
with time – particularly simple stereotyped movements (such as rocking). The development
of complex stereotyped movements is estimated to occur in 3–4% of children.
• Stereotyped movement disorder commonly co-occurs with disorders of intellectual
development and autism spectrum disorder.
Sex- and/or gender-related features
• Preschool-aged boys with autism spectrum disorder and with a disorder of intellectual
development tend to have higher rates of co-occurring stereotyped movement disorder.
Neurodevelopmental disorders | Stereotyped movement disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with autism spectrum disorder
Repetitive and stereotyped motor movements such as whole-body movements (e.g. rocking), gait
atypicalities (e.g. walking on tiptoes) and unusual hand or finger movements can be a characteristic
feature of autism spectrum disorder, but are differentiated from stereotyped movement disorder by
the presence of additional significant limitations in the capacity for reciprocal social interactions and
social communication. Assignment of both diagnoses may be warranted if the stereotyped motor
movements constitute a separate focus of clinical attention (e.g. due to self-injury).
Boundary with obsessive-compulsive disorder
In contrast to stereotyped movement disorder, repetitive behaviours (i.e. compulsions) observed in
obsessive-compulsive disorder are typically more complex, and are aimed at neutralizing unwanted
intrusive thoughts (i.e. obsessions) and reducing associated negative emotions (e.g. anxiety).
Boundary with body-focused repetitive behaviour disorders
Body-focused repetitive behaviour disorders (e.g. trichotillomania and excoriation disorder) are
characterized by recurrent and habitual behaviours directed at the integument (e.g. hair and skin).
In contrast, stereotyped movements in stereotyped movement disorder rarely include hair-pulling or
skin-picking behaviour; if they do, the behaviour tends to be composed of coordinated movements
that are patterned and predictable, utilizing the same muscle groups in a particular sequence to
produce the behaviour. In addition, stereotyped movements are more likely to present very early
in life (below 2 years of age), whereas body-focused repetitive behaviour disorders typically have
an onset in later childhood or early adolescence.
Boundary with Tourette syndrome and other tic disorders
In contrast to tic disorders including Tourette syndrome, stereotyped movements in stereotyped
movement disorder tend to be composed of coordinated movements that are patterned and
predictable, and can be interrupted with distraction. Stereotyped movement disorder is further
differentiated from tics and Tourette syndrome because the symptoms tend to emerge at a younger
age, last longer than typical tics, lack a premonitory sensory urge, and may be experienced as
enjoyable.
Boundary with drug-induced dystonia (tardive dyskinesia).
Drug-induced dystonia is a movement disorder (classified in Chapter 8 on diseases of the nervous
system) that is most frequently caused by antipsychotic medication. It is also sometimes referred
to as tardive dyskinesia. Symptoms may include involuntary oral or facial movements or, less
commonly, irregular trunk or limb movements. A diagnosis of stereotyped movement disorder is
not appropriate in such cases.
Boundary with diseases of the nervous system
Involuntary movements associated with diseases of the nervous system usually follow a typical
pattern with the presence of pathognomic signs and symptoms. If stereotyped movements are
associated with Lesch-Nyhan syndrome or another specific disease of the nervous system or
neurodevelopmental disease, stereotyped movement disorder should not be diagnosed unless
the movements become a separate focus of clinical attention. In such cases, both diagnoses may
be assigned.
Neurodevelopmental disorders | Stereotyped movement disorder

09 - 6A0Y Other specified neurodevelopmental disor
6A0Y Other specified neurodevelopmental disorder

10 - 6A0Z Neurodevelopmental disorder, unspecified
6A0Z Neurodevelopmental disorder, unspecified

100 - 6B6Y Other specified dissociative disorder
6B6Y Other specified dissociative disorder

101 - 6B6Z Dissociative disorder, unspecified
6B6Z Dissociative disorder, unspecified
395
Dissociative disorders
Boundary with post-traumatic stress disorder and complex post-traumatic
stress disorder
Experiences of depersonalization and derealization are common in post-traumatic stress
disorder, particularly during re-experiencing episodes such as flashbacks. If depersonalization or
derealization is limited to episodes of re-experiencing in an individual with post-traumatic stress
disorder or complex post-traumatic stress disorder, an additional diagnosis of depersonalizationderealization disorder should not be assigned. However, if clinically significant depersonalization
and derealization occurs outside or is persistent following re-experiencing episodes, and the
diagnostic requirements of both disorders are met, an additional diagnosis of depersonalizationderealization disorder may be assigned.
Boundary with personality disorder
Experiences of depersonalization or derealization may occur in personality disorder, especially
when the person is under stress. If the symptoms are better accounted for by personality disorder,
an additional diagnosis of depersonalization-derealization disorder should not be assigned.
Other specified dissociative disorder
Essential (required) features
• The presentation is characterized by symptoms that share primary clinical features with
other dissociative disorders (i.e. involuntary disruption or discontinuity in the normal
integration of one or more of the following: identity, sensations, perceptions, affects,
thoughts, memories, control over bodily movements or behaviour).
• The symptoms do not fulfil the diagnostic requirements of any of the other disorders in the
grouping of dissociative disorders.
• The symptoms are not better accounted for by another mental disorder (e.g. post-traumatic
stress disorder, complex post-traumatic stress disorder, schizophrenia, bipolar disorders).
• The symptoms are involuntary and unwanted, and are not accepted as a part of a collective
cultural or religious practice.
• The symptoms are not due to the effects of a substance or medication on the central nervous
system – including withdrawal effects – (e.g. blackouts or chaotic behaviour during
substance intoxication), and are not due to a disease of the nervous system (e.g. complex
partial seizures), a sleep-wake disorder (e.g. symptoms occur during hypnagogic or
hypnopompic states), head trauma or another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. If functioning is
maintained, it is only through significant additional effort.
Dissociative disorder, unspecified
6B6Y
6B6Z
Dissociative disorders | Other specified or unspecified dissociated disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

102 - Feeding and eating disorders
Feeding and eating disorders
397
Feeding and eating disorders
6B80
6B83
Avoidant-restrictive food intake disorder
6B81
Bulimia nervosa
6B82
Binge-eating disorder
Feeding and eating disorders
Anorexia nervosa
6B84
Pica
6B85
6B8Y
Other specified feeding or eating disorder
6B8Z
Feeding or eating disorder, unspecified.
Rumination-regurgitation disorder
Feeding and eating disorders involve abnormal eating or feeding behaviours that are not better
accounted for by another medical condition, and are not developmentally appropriate or culturally
sanctioned. Feeding disorders involve behavioural disturbances that are not related to body weight
or shape concerns, such as eating of non-edible substances or voluntary regurgitation of foods.
Eating disorders involve abnormal eating behaviour and preoccupation with food, accompanied
in most instances by prominent body weight or shape concerns.
Feeding and eating disorders include the following:
Feeding and eating disorder diagnoses should not be used to classify low-level concerns related to
eating or behaviours that are common or culturally sanctioned.
Feeding and eating disorders

103 - 6B80 Anorexia nervosa
6B80 Anorexia nervosa
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
General cultural considerations for feeding and eating disorders
• Weight and shape concerns are prevalent in many societies, and dieting to lose weight
is common. Cultural preoccupation with body weight and shape – for example, due to
global dissemination of body ideals through mass media (typically low weight in women
and muscular physique in men) – has contributed to increased rates of eating disorders
in many parts of the world. The global obesity epidemic has also contributed to social
concerns about eating and weight.
• The prevalence of feeding and eating disorders varies by region, including differences by
gender. For example, weight concerns and eating disturbances are more prevalent among
men in some Asian and eastern Mediterranean societies than in the Americas.
Anorexia nervosa
Essential (required) features
• Significantly low body weight for the individual’s height, age, developmental stage or weight
history is required for diagnosis. A commonly used threshold is body mass index (BMI)
of less than 18.5 kg/m2 in adults and BMI for age under the 5th percentile in children
and adolescents. Rapid weight loss (e.g. more than 20% of total body weight within 6
months) may replace the essential feature of low body weight, as long as other diagnostic
requirements are met. Children and adolescents may exhibit failure to gain weight as
expected based on the individual developmental trajectory rather than weight loss.
• Low body weight is not better accounted for by another medical condition or the
unavailability of food.
• The presentation is characterized by a persistent pattern of restrictive eating or other
behaviours aimed at establishing or maintaining abnormally low body weight, typically
associated with extreme fear of weight gain. Behaviours may be aimed at reducing energy
intake by fasting, choosing low-calorie food, excessively slow eating of small amounts
of food, and hiding or spitting out food, as well as by purging behaviours such as selfinduced vomiting and use of laxatives, diuretics or enemas, or omission of insulin doses in
individuals with diabetes. Behaviours may also be aimed at increasing energy expenditure
through excessive exercise, motor hyperactivity, deliberate exposure to cold and use of
medication that increases energy expenditure (e.g. stimulants, weight-loss medication,
herbal products for reducing weight, thyroid hormones).
• Excessive preoccupation with body weight or shape is apparent. Low body weight is
overvalued and central to the person’s self-evaluation, or the person’s body weight or shape
is inaccurately perceived to be normal or even excessive. Preoccupation with weight or
shape, when not explicitly reported, may be manifested in behaviours such as repeatedly
checking body weight using scales; repeatedly checking body shape using tape measures
or reflection in mirrors; constantly monitoring the calorie content of food or searching for
6B80
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information on how to lose weight; or exhibiting extreme avoidant behaviours, such as
refusal to have mirrors at home, avoidance of tight-fitting clothes, or refusal to know one’s
weight or to purchase clothing with specified sizing.
Specifiers for underweight status
In the context of anorexia nervosa, severe underweight status is an important prognostic factor
that is associated with a high risk of physical complications and substantially increased mortality.
In adults, very low BMI has been found to be associated with poorer long-term prognosis among
individuals with anorexia nervosa, although it is not the sole determinant of medical risk.
Anorexia nervosa with significantly low body weight
• Anorexia nervosa with significantly low body weight meets all diagnostic requirements for
anorexia nervosa, with BMI between 18.5 kg/m2 and 14.0 kg/m2 in adults or BMI for age
between the 5th and 0.3rd percentile in children and adolescents.
Anorexia nervosa with dangerously low body weight
• Anorexia nervosa with dangerously low body weight meets all diagnostic requirements for
anorexia nervosa, with BMI of under 14.0 kg/m2 in adults or BMI for age under the 0.3rd
percentile (fewer than three in one thousand) in children and adolescents. In the context
of anorexia nervosa, dangerously low body weight is an important prognostic factor that is
associated with a high risk of physical complications and substantially increased mortality.
Anorexia nervosa in recovery with normal body weight
• Among individuals who are recovering from anorexia nervosa who have achieved a healthy
body weight, the diagnosis should be retained until a full and lasting recovery is achieved.
A full and lasting recovery includes maintenance of a healthy weight and the cessation
of behaviours aimed at reducing body weight for a sustained period (e.g. at least 1 year)
following the termination of treatment.
Other specified anorexia nervosa
Anorexia nervosa, unspecified
6B80.0
6B80.1
6B80.2
6B80.Y
6B80.Z
Feeding and eating disorders | Anorexia nervosa
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Specifiers for the pattern of weight-related behaviours
Different patterns of weight-related behaviours among individuals with anorexia nervosa may be
related to treatment selection and clinical management, as well as the course and outcome of the
disorder. The following specifiers may be applied to 6B80.0 Anorexia nervosa with significantly
low body weight and 6B80.1 Anorexia nervosa with dangerously low body weight. (The x below
corresponds to the fifth-character code 0 or 1, indicating the individual’s underweight status.)
6B80.x0 restricting pattern
The restricting pattern specifier should be assigned to individuals with anorexia
nervosa who induce weight loss and maintain low body weight through restricted
food intake or fasting, alone or in combination with increased energy expenditure
(e.g. through excessive exercise), but who do not engage in binge-eating or purging
behaviours.
6B80.x1 binge-purge pattern
The binge-purge pattern specifier should be assigned to individuals with anorexia
nervosa who present with episodes of binge-eating or purging behaviours aimed at
getting rid of ingested food (e.g. self-induced vomiting, laxative abuse or enemas).
This type of anorexia nervosa also includes individuals who exhibit binge-eating
episodes but do not purge.
6B80.xZ unspecified
Additional clinical features
• Signs of low body weight may include visible or measurable signs of starvation, such
as emaciation (lack of fat and muscle mass), extremities that feel cold to the touch or
appear blue, hair loss, growth of fine “lanugo” hair, oedema, proximal muscle weakness,
amenorrhea, osteopenia or osteoporosis, slow heart rate and low blood pressure.
• An explicitly stated fear of weight gain is not an absolute requirement for the diagnosis of
anorexia nervosa, as long as the behaviours maintaining underweight status appear to be
intentional, and there are other behavioural indicators of preoccupation with body weight
or shape (e.g. repeated checking or monitoring, or extreme avoidance behaviours).
• Individuals with anorexia nervosa often show a persistent lack of recognition that they
are underweight or excessively thin, and dismiss objective evidence regarding their actual
weight or shape and the seriousness of their condition.
• Medical risk among individuals with anorexia nervosa is not solely dependent on weight
status. Medical assessment should take into account other important medical risk factors
as part of a comprehensive physical examination. Other risk factors include, but are not
limited to, rapid weight loss (especially in children), orthostatic hypotension, bradycardia
or postural tachycardia, hypothermia, cardiac arrhythmia and biochemical disturbance.
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Boundary with normality (threshold)
• Anorexia nervosa must be associated with significantly low body weight for the individual’s
height, age, developmental stage or weight history, and with extreme attitudes and
behaviours that distinguish it from normal dieting and “normative discontent” with one’s
body shape and weight.
Course features
• Anorexia nervosa often has its onset during adolescence or early adulthood (i.e. between
the ages of 10 and 24 years), typically following a stressful life event. Early-onset anorexia
nervosa (prior to puberty) and late-onset anorexia nervosa (after the age of 40 years) are
relatively rare.
• Many individuals display a period of altered eating behaviours prior to meeting the full
diagnostic requirements for anorexia nervosa.
• Although some individuals recover fully after a single episode of anorexia nervosa, many
experience a chronic course of illness over many years.
• Individuals with severe symptoms of anorexia nervosa may require hospitalization to
restore weight and address medical complications. These individuals are less likely to
experience remission of symptoms.
• Most individuals diagnosed with anorexia nervosa experience remission within 5 years
of onset. However, even after an individual no longer meets the diagnostic requirements
for anorexia nervosa, they are more likely to have a lower body weight and increased
psychological features associated with anorexia nervosa (e.g. perfectionism) compared to
the general population.
• Anorexia nervosa is associated with premature death, often due to medical complications
of starvation or to suicide.
Developmental presentations
• Children with anorexia nervosa may not be able to articulate body-image concerns and
emotions related to restrictive eating. Presenting features among children may include
avoidance of food intake with denial of the severity of malnutrition for reasons other than
body-image concerns (e.g. reporting they are “not hungry” or have abdominal pain), as
well as nonverbal forms of food refusal.
• Children with anorexia nervosa are less likely to engage in binge eating and purging, or to
engage in other compensatory behaviours.
• The prognosis for adolescents diagnosed with anorexia nervosa is better than the prognosis
for adults with anorexia nervosa.
Feeding and eating disorders | Anorexia nervosa
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Older individuals with anorexia nervosa who have had a longer duration of illness often
exhibit chronic medical complications.
Culture-related features
• Symptom presentation of anorexia nervosa varies across cultural groups. For example,
in Asia, a subset of individuals with anorexia nervosa may not express fear of weight
gain (sometimes referred to as “fat phobia”) as a rationale for reducing energy intake.
Instead, dietary restriction may be attributed to gastrointestinal discomfort or to cultural
or religious motives (fasting or dietary rules). Such cases should still be regarded as
meeting the excessive preoccupation with body weight or shape essential feature if clinical
observation or collateral history supports the conclusion that they are motivated by an
intention to lose weight or to prevent weight gain.
• Anorexia nervosa occurs in all cultures, but cross-cultural variations exist in prevalence
and presentation. For example, the incidence of anorexia nervosa is greater in high-income
countries and in populations with higher levels of globalization and related transformations
in sociocultural values, gender roles, work, food supply and lifestyle. The prevalence of
anorexia nervosa is very low in Africa and Latin America, and among African Americans
and Latin Americans in the United States compared to the prevalence found in Europe and
some Asian countries, such as China and Japan.
• The prevalence of anorexia nervosa among men is increasing globally, and more men are
presenting for treatment of the disorder.
Sex- and/or gender-related features
• Globally, anorexia nervosa is up to 10 times more commonly diagnosed among females.
Lifetime prevalence among women has been reported to be between 0.8% and 6.3% in
Western settings. Emerging studies from eastern Europe, Asia and Latin America show a
similar range of prevalence.
• Less is known about the true prevalence of anorexia nervosa in males. However, there is
evidence that incidence and detection of anorexia nervosa in males is increasing.
• The onset of anorexia nervosa is earlier in females.
• Laxative abuse is more common among females; excessive exercise is more common
among males.
• Males with anorexia nervosa are more likely to be preoccupied with being insufficiently
muscular or lean – in response, they may exhibit unusual eating behaviours (e.g. excessive
protein consumption along with caloric restriction) or engage in excessive exercise for the
purpose of attaining and maintaining low body weight or a low percentage of body fat. If
low body weight and low body weight idealization are not part of the clinical presentation,
a diagnosis of body dysmorphic disorder should be considered (see the section on
boundaries with other disorders and conditions (differential diagnosis) below).
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Feeding and eating disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with bulimia nervosa
Individuals with anorexia nervosa may engage in binge eating and purging, but can be
distinguished from individuals with bulimia nervosa by their very low body weight. A significant
proportion of individuals with anorexia nervosa continue to exhibit binging and/or purging
symptoms after they have regained a more normal weight. In such cases, the diagnosis may be
changed to bulimia nervosa after 1 year during which body weight has not been sufficiently low
to meet the diagnostic requirements of anorexia nervosa.
Boundary with avoidant-restrictive food intake disorder
Behaviours to establish or maintain an abnormally low body weight in anorexia nervosa are usually
explicitly motivated by a desire for thinness or an intense fear of gaining weight. However, other
rationales for disturbances in eating behaviours or weight loss in anorexia nervosa may be given,
such as fear of physical discomfort (e.g. stomach bloating), self-punishment, or religious or moral
reasons. In cases in which the individual otherwise meets the diagnostic requirements of anorexia
nervosa but weight- or shape-related concerns are not explicitly endorsed, the altered eating
behaviours should only be considered as diagnostic of anorexia nervosa if clinical observation or
collateral history supports the conclusion that they are motivated by an intention to lose weight
or to prevent weight gain. When such individuals begin to alter their eating behaviours and to
gain weight, often as a result of treatment, it is common for more explicit weight- or shape-related
concerns to emerge. In cases where concerns about body weight or shape continue to be absent in
spite of alteration of eating behaviours and weight gain, it is generally more appropriate to change
the diagnosis to avoidant-restrictive food intake disorder.
Boundary with schizophrenia and other primary psychotic disorders
Beliefs that may be considered unusual, are demonstrably untrue, or even appear to be delusional
in intensity or fixity may be present in individuals with anorexia nervosa, but these are generally
restricted to issues of food, weight and shape, and are otherwise consistent with the psychopathology
of anorexia nervosa. Examples include a conviction that one is fat when one is demonstrably
underweight, or a belief that one’s caloric intake is excessive when it is in fact insufficient to
maintain a normal weight. Such beliefs are consistent with a diagnosis of anorexia nervosa, and
an additional diagnosis of delusional disorder or other psychotic disorder is not warranted in
such cases. However, if other delusional beliefs are present (e.g. persecutory delusions that are
unrelated to weight, shape or food intake) or there are other psychotic symptoms (e.g. thought
disorder, hallucinations), a separate diagnosis of a primary psychotic disorder may be warranted.
Boundary with obsessive-compulsive disorder
Individuals with anorexia nervosa often experience repetitive and persistent thoughts about their
weight or shape or about food, which can resemble obsessions. They may also engage in repetitive
behaviours in response to these thoughts (e.g. exercise, purging). If repetitive thoughts and
behaviours are limited to concerns about weight or shape or about food, an additional diagnosis
of obsessive-compulsive disorder should not be assigned.
Boundary with body dysmorphic disorder
Body dysmorphic disorder is distinguished from anorexia nervosa in that preoccupations and
body-image disturbance in body dysmorphic disorder are focused on features other than overall
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104 - 6B81 Bulimia nervosa
6B81 Bulimia nervosa
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
weight, shape and size (e.g. preoccupation with the nose or skin), and are not accompanied by
disturbance in eating behaviour or marked weight loss. Some individuals (primarily males) with
body dysmorphic disorder exhibit muscle dysmorphia such that they are preoccupied about
being insufficiently muscular or lean and, in response, may exhibit unusual eating behaviours
(e.g. excessive protein consumption) or engage in excessive exercise (e.g. weightlifting). In these
cases, behaviours related to diet and exercise are motivated by a desire to be more muscular rather
than to attain or maintain a low body weight. However, if low body weight idealization is central
to the clinical presentation, and body weight is sufficiently low, a diagnosis of anorexia nervosa
instead of body dysmorphic disorder should be assigned.
Bulimia nervosa
Essential (required) features
• Frequent, recurrent episodes of binge eating (e.g. once a week or more over a period of at
least 1 month) are required for diagnosis. Binge eating is defined as a discrete period of time
(e.g. 2 hours) during which the individual experiences a loss of control over their eating
behaviour, and eats notably more or differently than usual. Loss of control over eating may
be described by the individual as feeling like they cannot stop or limit the amount or type
of food eaten; having difficulty stopping eating once they have started; or giving up even
trying to control their eating because they know they will end up overeating.
• The presentation is characterized by repeated inappropriate compensatory behaviours to
prevent weight gain (e.g. once a week or more over a period of at least 1 month). The most
common compensatory behaviour is self-induced vomiting, which typically occurs within
an hour of binge eating. Other inappropriate compensatory behaviours include fasting or
using diuretics to induce weight loss, using laxatives or enemas to reduce the absorption
of food, omission of insulin doses in individuals with diabetes, and strenuous exercise to
greatly increase energy expenditure.
• Excessive preoccupation with body weight or shape is apparent. Preoccupation with weight
or shape, when not explicitly reported, may be manifested in behaviours such as repeatedly
checking body weight using scales; repeatedly checking body shape using tape measures
or reflection in mirrors; constantly monitoring the calorie content of food or searching for
information on how to lose weight; or exhibiting extreme avoidant behaviours, such as
refusal to have mirrors at home, avoidance of tight-fitting clothes, or refusal to know one’s
weight or to purchase clothing with specified sizing.
• There is marked distress about the pattern of binge eating and inappropriate compensatory
behaviour, or significant impairment in personal, family, social, educational, occupational
or other important areas of functioning. During the early phases of the disorder, symptoms
may be concealed and functioning maintained through significant additional effort.
• The symptoms do not meet the diagnostic requirements for anorexia nervosa.
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Feeding and eating disorders
Additional clinical features
• Binge-eating episodes may be “objective”, in which the individual eats an amount of food
that is larger than what most people would eat under similar circumstances, or “subjective”,
which may involve eating amounts of food that might be objectively considered to be within
normal limits but are subjectively experienced as large by the individual. In either case, the
core feature of a binge-eating episode is the experience of loss of control over eating.
• Additional characteristics of binge-eating episodes may include eating much more rapidly
than usual, eating until feeling uncomfortably full, eating large amounts of food when not
feeling physically hungry, or eating alone because of embarrassment.
• Binge eating is typically experienced as very distressing. This is often manifested in
negative emotions such as guilt, disgust or shame, which also typically negatively affect the
individual’s self-evaluation.
• Bulimia nervosa may be associated with weight gain over time. However, individuals with
bulimia nervosa may be of normal weight or even low weight (although not sufficiently
low to meet the diagnostic requirements for anorexia nervosa). The diagnosis of bulimia
nervosa is based on the presence of regular binge eating and inappropriate compensatory
behaviours, regardless of overweight status.
Boundary with normality (threshold)
• Infrequent overeating or feasting during culturally sanctioned holidays or occasional
celebrations should not be characterized as binge eating for the purpose of assigning a
diagnosis of bulimia nervosa. Similarly, exercise qualifies as inappropriate compensatory
behaviour only if it is unusually intensive or prolonged, or is carried out to the exclusion of
other activities or in spite of fatigue, pain or injury.
Course features
• Like anorexia nervosa, bulimia nervosa most commonly has its onset during the period
from adolescence to early adulthood (i.e. between the ages of 10 and 24 years), typically
following a stressful life event. Onset prior to puberty or after the age of 40 years is
relatively rare.
• Bulimia nervosa is characterized by a variable course that can manifest as persistent
symptoms or intermittent episodes of remission and exacerbation. Outcome appears to be
related to course, such that individuals whose symptoms remit for a period longer than 1
year tend not to experience relapse of the disorder.
Feeding and eating disorders | Bulimia nervosa
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Individuals with bulimia nervosa are at a significantly increased risk of substance use,
suicidality and health complications (e.g. gastrointestinal problems) that can lead to
premature death.
• Some individuals may cease purging or compensatory behaviours but continue to engage
in binge eating. In this case, the diagnosis may be changed to binge-eating disorder if all
diagnostic requirements are met.
• Stressful life events or a history of anorexia nervosa increase the likelihood of the onset
of bulimia nervosa. A restricting pattern in anorexia nervosa may evolve over time into
a pattern of binging and purging in bulimia nervosa. In such cases, the diagnosis may be
changed to bulimia nervosa after 1 year during which body weight has not been sufficiently
low to meet the diagnostic requirements of anorexia nervosa.
Developmental presentations
• Onset of bulimia nervosa typically occurs during or shortly after puberty. Young children
do not commonly engage in binge eating due to a lack of access and control of
food availability.
Culture-related features
• The prevalence of bulimia nervosa is higher in cultures characterized by an idealized thin
body ideal. In addition, the prevalence of bulimia nervosa is increasing in countries that
are industrializing and transitioning to more global and urbanized societies.
• The distribution of bulimia nervosa across cultural groups within a society can change
over time. For example, in the United States, the incidence of the disorder appears to be
decreasing among Euro-American females and increasing among ethnic minority groups –
particularly Latin Americans and African Americans.
• Purging methods may be locally specific, such as the use of herbal purgatives in Asia and
the Pacific region (e.g. seaweed and herbal teas in Japan; indigenous tea in Fiji), and justified
with medicinal or other rationales that may obscure their pathological significance.
Sex- and/or gender-related features
• Bulimia nervosa is more prevalent among females.
• Males are less likely than females to engage in purging behaviours, and have a greater
tendency to use excessive exercise or steroids as compensatory behaviours in response to
binges. Males are also less likely to seek treatment.
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105 - 6B82 Binge eating disorder
6B82 Binge-eating disorder
407
Feeding and eating disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with anorexia nervosa
Individuals with anorexia nervosa may engage in binge eating and purging, but can be
distinguished from individuals with bulimia nervosa by their very low body weight. If binge
eating and purging are associated with very low body weight (i.e. BMI of less than 18.5 kg/m2 in
adults and BMI for age under the 5th percentile in children and adolescents), and all the other
diagnostic requirements are met, a diagnosis of anorexia nervosa, binge-purge pattern, rather
than bulimia nervosa should be assigned. Moreover, a significant proportion of individuals with
anorexia nervosa continue to exhibit binging or purging behaviours after they have regained a
more normal weight. In such cases, the diagnosis may be changed to bulimia nervosa after 1 year
during which body weight has not been sufficiently low to meet the diagnostic requirements of
anorexia nervosa.
Boundary with binge-eating disorder
Binge eating that is not associated with regular compensatory behaviours should be diagnosed as
binge-eating disorder rather than bulimia nervosa.
Binge-eating disorder
Essential (required) features
• Frequent, recurrent episodes of binge eating (e.g. once a week or more over a period of
3 months) are required for diagnosis. Binge eating is defined as a discrete period of time
(e.g. 2 hours) during which the individual experiences a loss of control over their eating
behaviour and eats notably more or differently than usual. Loss of control over eating may
be described by the individual as feeling like they cannot stop or limit the amount or type
of food eaten; having difficulty stopping eating once they have started; or giving up even
trying to control their eating because they know they will end up overeating.
• The binge-eating episodes are not regularly accompanied by inappropriate compensatory
behaviours aimed at preventing weight gain.
• The symptoms and behaviours are not better accounted for by another medical condition
(e.g. Prader-Willi syndrome) or mental disorder (e.g. a depressive disorder), and are not
due to the effects of a substance or medication on the central nervous system, including
withdrawal effects.
• There is marked distress about the pattern of binge eating, or significant impairment in
personal, family, social, educational, occupational or other important areas of functioning.
During the earlier phases of the disorder, symptoms may be concealed and functioning
maintained through significant additional effort.
6B82
Feeding and eating disorders | Binge-eating disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Binge-eating episodes may be “objective”, in which the individual eats an amount of food
that is larger than most people would eat under similar circumstances, or “subjective”,
which may involve eating amounts of food that might be objectively considered to be within
normal limits but are subjectively experienced as large by the individual. In either case, the
core feature of a binge-eating episode is the experience of loss of control over eating.
• Additional characteristics of binge-eating episodes may include eating much more rapidly
than usual, eating until feeling uncomfortably full, eating large amounts of food when not
feeling physically hungry, or eating alone because of embarrassment.
• Binge eating is typically experienced as very distressing. This is often manifested in
negative emotions such as guilt, disgust or shame, which also typically negatively affect the
individual’s self-evaluation.
• When there are multiple binge-eating episodes per week and these are associated with
significant distress, it may be appropriate to assign the diagnosis after a shorter period
(e.g. 1 month).
• Binge-eating disorder is often associated with weight gain over time and obesity. However,
individuals with binge-eating disorder may be of normal weight or even low weight
(although not sufficiently to meet the diagnostic requirements for anorexia nervosa).
The diagnosis of binge-eating disorder is based on the presence of regular binge eating
that is not accompanied by regular inappropriate compensatory behaviours, regardless of
overweight status.
• Preoccupation with one’s body weight or shape, frequent checking or avoidance of checking
body weight or size, and strong influence of body weight or shape on self-evaluation are
commonly present, although not required for a diagnosis of binge-eating disorder.
Boundary with normality (threshold)
• Infrequent overeating or feasting during culturally sanctioned holidays or occasional
celebrations should not be characterized as binge eating for the purpose of assigning a
diagnosis of binge-eating disorder.
• Individuals who report patterns of overeating that do not meet the definition of binge
eating should not be diagnosed with binge-eating disorder. Examples include mindless
eating that can be resisted or stopped (e.g. if there is a distraction or interruption), or
eating more than originally intended without a sense of loss of control, even if this kind of
eating is distressing.
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Feeding and eating disorders
Course features
• Onset of binge-eating disorder is typically during adolescence or young adulthood, but can
also begin in later adulthood.
• The experience of loss of control over eating or sporadic episodes of binge eating may
occur prior to the onset of binge-eating disorder.
• Binge-eating disorder is more common among individuals seeking weight-loss treatment.
Typically, these individuals seek weight-loss treatment after the onset of the disorder; binge
eating does not typically arise as a consequence of treatment.
• Binge-eating disorder occurs more often among overweight and obese individuals than
those with normal BMI.
• Individuals who seek treatment for binge-eating disorder are typically older in age
compared to individuals who seek treatment for other feeding and eating disorders.
• Binge-eating disorder, although often persistent, has a higher rate of remission than other
feeding and eating disorders, with remission sometimes occurring spontaneously.
• The features of binge-eating disorder may evolve over time, such that another feeding or
eating disorder may better characterize the current symptoms.
Developmental presentations
• In children, as in adults, binge-eating disorder is associated with weight gain, increased
body fat, concealing one’s eating and use of binge eating to regulate emotions.
• Binge-eating disorder is more difficult to diagnose in childhood due to normative difficulty
engaging in introspection in order to articulate reasons for binge-eating behaviour.
Children are likely to report feeling out of control while eating rather than indicating that
the amount of food consumed was excessive.
• Children with binge-eating disorder may experience less frequent and briefer binges than
adults because they typically cannot gain access to food without the assistance of adults.
• Binge-eating disorder is common among adolescents and young adults.
Culture-related features
• Compared to other feeding and eating disorders, binge-eating disorder appears to be
more equally distributed across countries, ethnic groups and genders. The prevalence of
binge-eating disorder is at least as high in low- and middle-income countries as across
high-income countries, and tends to correlate with rise of BMI in the general population.
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106 - 6B83 Avoidant restrictive food intake disorde
6B83 Avoidant-restrictive food intake disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The relationship between ideal body size, body satisfaction and binge-eating disorder is
complex. For example, women who report strong identification with African American or
Black Caribbean culture also tend to report larger body ideals and higher body satisfaction,
yet tend to have elevated rates of binge eating.
Sex- and/or gender-related features
• Binge-eating disorder is more prevalent among females.
• There are no significant gender-related differences in the symptoms or course of bingeeating disorder.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with bulimia nervosa
If an individual regularly engages in inappropriate compensatory behaviours following episodes
of binge eating (e.g. self-induced vomiting, use of laxatives, enemas, diuretics, fasting, strenuous
exercise or omitting insulin), a diagnosis of bulimia nervosa rather than binge-eating disorder
should be assigned.
Boundary with obesity
Obesity is a common consequence of binge-eating disorder and should be recorded separately.
However, obese individuals who report overeating patterns that do not meet the definition of
binge eating should not be diagnosed with binge-eating disorder.
Avoidant-restrictive food intake disorder
Essential (required) features
• Avoidance or restriction of food intake is required for diagnosis, which results in either or
both of the following:
• the intake of an insufficient quantity or variety of food to meet adequate energy or
nutritional requirements that has resulted in significant weight loss, clinically significant
nutritional deficiencies, dependence on oral nutritional supplements or tube feeding, or
has otherwise negatively affected the physical health of the individual;
• significant impairment in personal, family, social, educational, occupational or other
important areas of functioning (e.g. due to avoidance or distress related to participating
in social experiences involving eating).
6B83
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Feeding and eating disorders
• The pattern of eating behaviour is not motivated by preoccupation with body weight or
shape.
• Restricted food intake and consequent weight loss (or failure to gain weight), or other
impacts on physical health or related functional impairment, are not due to unavailability
of food; are not a manifestation of another medical condition (e.g. food allergies,
hyperthyroidism) or mental disorder; and are not due to the effects of a substance or
medication, including withdrawal effects.
Additional clinical features
• A variety of reasons may be given for restriction of food intake, such as lack of interest in
eating, avoidance of foods with certain sensory characteristics (e.g. smell, taste, appearance,
texture, colour, temperature) or concern about perceived aversive consequences of eating
(e.g. choking, vomiting, health problems), which in some cases is related to a history of
aversive food-related experience such as choking or vomiting after eating a particular type
of food. In many cases, however, there is no identifiable event that preceded the onset of
the disorder.
• Some individuals with avoidant-restrictive food intake disorder present with a longstanding
lack of interest in food or eating, chronically low appetite or poor ability to recognize
hunger. In other cases, restriction of food intake may be more variable and significantly
affected by emotional or psychological factors. This latter pattern may be associated with
high levels of distractibility or with high levels of emotional arousal and extreme resistance
in situations in which eating is expected. Individuals with this pattern, especially children,
often require significant prompting and encouragement to eat.
• Individuals with avoidant-restrictive food intake disorder generally do not experience any
difficulties eating foods within their preferred range, and may therefore not be underweight.
• Avoidant-restrictive food intake disorder can negatively affect family functioning, such
that mealtimes may be associated with increased distress (e.g. infants may be more irritable
during feeding, children may try to negotiate what food is present or how much they need
to consume at mealtimes).
Boundary with normality (threshold)
• People with unusual patterns of eating behaviour or who are exceptionally “picky eaters”
should not be diagnosed with avoidant-restrictive food intake disorder in the absence of
significant weight loss or other health consequences (e.g. clinically significant nutritional
deficiencies, increases in blood lipids due to selective eating of fatty foods) or impairment
in psychosocial functioning (e.g. limited participation in social activities where preferred
foods are not available). Distress on the part of parents or other caregivers related to
selective eating in the absence of identifiable health consequences or impairment in the
individual’s functioning is not a basis for assigning the diagnosis.
Feeding and eating disorders | Avoidant-restrictive food intake disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Avoidance of specific foods or limitation of food intake due to religious or other culturally
sanctioned practices does not meet the diagnostic requirements of avoidant-restrictive
food intake disorder unless the pattern of restricted food intake has negatively affected the
physical health of the individual or resulted in significant impairment in personal, family,
social, educational, occupational or other important areas of functioning.
Course features
• Avoidant-restrictive food intake disorder may be associated with delays in typical
development (e.g. growth, learning), particularly if significant malnutrition is present.
• Among individuals with avoidant-restrictive food intake disorder, avoidant and restrictive
patterns of eating may persist into adulthood.
• Individuals with avoidant-restrictive food intake disorder may develop certain features of
anorexia nervosa over time (e.g. concerns about body weight or negative attitudes about
fatness), but do not typically develop the body image distortion commonly seen in anorexia
nervosa. Otherwise, evidence that avoidant-restrictive food intake disorder is associated
with later diagnoses of other feeding and eating disorders is limited.
Developmental presentations
• Avoidant eating or feeding often starts in early childhood, but initial presentations in older
children, adolescents and adults also occur.
Culture-related features
• Individuals who avoid specific foods because of widely accepted food choice practices, such
as vegetarianism or veganism, or due to religious observances (e.g. fasting, purification or
ritual proscription of foods), should not be diagnosed with the disorder unless the restricted
eating behaviour exceeds the usual norms of the individual’s cultural or religious group,
and is associated with health or functional consequences that warrant clinical attention.
Sex- and/or gender-related features
• The prevalence of avoidant-restrictive food intake disorder is similar among males and
females. When avoidant-restrictive food intake disorder co-occurs with autism spectrum
disorder, prevalence is higher among males.
Feeding and eating disorders | Avoidant-restrictive food intake disorder
413
Feeding and eating disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with anorexia nervosa
Individuals with anorexia nervosa, like individuals with avoidant-restrictive food intake disorder,
present with a pattern of restricted eating and significantly low body weight, with similar
health-related consequences. The difference is that in anorexia nervosa, behaviours to establish
or maintain an abnormally low body weight are usually explicitly motivated by a desire for
thinness or an intense fear of gaining weight. However, other rationales for disturbances in eating
behaviours or weight loss in anorexia nervosa may be given, such as fear of physical discomfort
(e.g. stomach bloating), self-punishment, or religious or moral reasons. In cases in which the
individual otherwise meets the diagnostic requirements of anorexia nervosa but weight- or
shape-related concerns are not explicitly endorsed, the altered eating behaviours should only be
considered diagnostic of anorexia nervosa if clinical observation or collateral history supports the
conclusion that they are motivated by an intention to lose weight or to prevent weight gain. Some
individuals initially diagnosed with avoidant-restrictive food intake disorder may exhibit more
explicit weight- or shape-related concerns over the course of treatment as they begin to alter their
eating behaviours and to gain weight. In such cases, it may be appropriate to change the diagnosis
to anorexia nervosa if all diagnostic requirements are met.
Boundary with autism spectrum disorder
In some individuals with avoidant-restrictive food intake disorder, the pattern of food avoidance
stems from sensory sensitivities related to the smell, taste, temperature, texture or appearance
of foods. For example, an individual may eat only foods of a particular colour, or will refuse
solids or accept only a very narrow range of foods based on packaging or a particular brand.
Some individuals with autism spectrum disorder may also restrict intake of certain foods because
of their sensory characteristics (e.g. hypersensitivity to food texture) or because of inflexible
adherence to particular routines (e.g. eating the same foods at the same time in the same order or
only eating specific brands of food with specific packaging). However, autism spectrum disorder
is also characterized by persistent deficits in initiating and sustaining social communication
and reciprocal social interactions, and persistent restricted, repetitive and inflexible patterns of
behaviour, interests or activities that are unrelated to food. If a pattern of restricted eating in
an individual with autism spectrum disorder has caused significant weight loss or other health
consequences or is specifically associated with significant functional impairment, an additional
diagnosis of avoidant-restrictive food intake disorder may be assigned.
Boundary with specific phobia and other anxiety and fear-related disorders
In some individuals with avoidant-restrictive food intake disorder, food avoidance may be related
to perceived aversive consequences of eating (e.g. fear that swallowing particular foods may cause
one to gag, choke or vomit, or concern about the development of health problems such as heart
disease or cancer related to food intake). Avoidant-restrictive food intake disorder is commonly
associated with anxiety symptoms in situations related to eating or food, which may become
worse over time as the disorder evolves. If the pattern and intensity of anxiety symptoms in an
individual with avoidant-restrictive food intake disorder meet all diagnostic requirements of
specific phobia or another anxiety or fear-related disorder, both diagnoses may be assigned.
Feeding and eating disorders | Avoidant-restrictive food intake disorder

107 - 6B84 Pica
6B84 Pica
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with other mental disorders
Individuals experiencing a depressive episode may present with a lack of appetite or reduced
interest in eating, and weight loss associated with depressed mood and other cognitive-behavioural
or neurovegetative symptoms of a depressive episode. Similarly, individuals experiencing manic,
mixed or hypomanic episodes may exhibit reduced interest in eating together with other features
of a bipolar disorder. Avoidance or restriction of food intake with effects on weight and nutrition
can also be present in schizophrenia and other primary psychotic disorders due to loss of appetite
or due to paranoid ideas (e.g. fear of being poisoned). Motivations for restricted eating should
be investigated carefully as a part of a complete mental health assessment in order to distinguish
among these conditions. An additional diagnosis of avoidant-restrictive food intake disorder
is generally not warranted if the restriction of food intake is fully accounted for by another
mental disorder.
Boundary with other medical conditions
Avoidant-restrictive food intake disorder should not be diagnosed if the eating disturbance is
entirely accounted for by a gastrointestinal disorder or another medical condition that leads to
reduced hunger, restricted eating or weight loss (e.g. food allergies, infectious diseases, cancer,
hyperthyroidism).
Pica
Essential (required) features
• Regular consumption of non-nutritive substances, such as non-food objects and materials
(e.g. clay, soil, chalk, plaster, plastic, metal and paper), or raw food ingredients (e.g. large
quantities of salt or corn flour) is required for diagnosis.
• The ingestion of non-nutritive substances is persistent or severe enough to require clinical
attention. That is, the behaviour causes damage or significant risk to health or impairment
in functioning due to the frequency, amount or nature of the substances or objects ingested.
• Based on age and level of intellectual functioning, the individual would be expected to
distinguish between edible and non-edible substances. In typical development, this occurs
at approximately 2 years of age.
• The symptoms or behaviours are not a manifestation of another medical condition (e.g.
nutritional deficiency).
Boundary with normality (threshold)
• It is normal for infants and very young children to put non-food objects in their mouths
as a means of sensory exploration. The diagnosis of pica should not be applied to
this phenomenon.
6B84
Feeding and eating disorders | Pica
415
Feeding and eating disorders
• Many pregnant women crave or eat non-nutritive substances (e.g. chalk or ice). In addition,
the eating of non-nutritive substances is a culturally sanctioned practice among certain
groups. A diagnosis of pica should only be assigned to such behaviour if it is persistent or
potentially dangerous enough to require specific clinical attention.
Course features
• Pica can be episodic and variable, or chronic and continuous. When variable, consumption
of non-nutritive substances may be associated with increased levels of stress or anxiety.
Developmental presentations
• Onset of pica can occur across the lifespan, but is most commonly observed in childhood.
Culture-related features
• In some cases, eating of non-nutritive substances may be a culturally sanctioned practice.
In these cases, consumption of the non-nutritive substance is thought to have some health,
spiritual or social benefit. In parts of Africa and certain rural areas of the United States
and India, for example, the eating of clay or earth (geophagia) can be a culturally accepted
practice. Pica should not be diagnosed in such cases unless the quantities ingested are large
enough to require clinical attention.
Sex- and/or gender-related features
• The prevalence of pica is similar among males and females.
• Although females can be diagnosed with pica during pregnancy and the postpartum
period, a diagnosis should only be assigned if consumption of non-nutritive substances is
persistent or potentially dangerous enough to require specific clinical attention.
Feeding and eating disorders | Pica

108 - 6B85 Rumination regurgitation disorder
6B85 Rumination-regurgitation disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with nutritional deficiencies
Individuals who ingest non-nutritive substances as a symptom of specific nutritional deficiencies
should not be diagnosed with pica unless the behaviour persists after the deficiency is corrected.
For example, anaemia caused by vitamin B12, folate or iron deficiency can be associated with a
craving to eat dirt.
Boundary with disorders of intellectual development
The ingestion of non-nutritive substances is common in children or adults with disorders
of intellectual development. An additional diagnosis of pica may be given, as long as that the
individual is able to distinguish between edible and non-edible substances, if the behaviour is
persistent or potentially dangerous enough to require specific clinical attention.
Boundary with factitious disorder and malingering
Individuals with factitious disorder or who are malingering may swallow harmful substances
or objects in order to present themselves as ill. For example, prisoners may swallow harmful
substances or objects in order to be transferred to hospital or to a setting that is less harsh or less
restrictive. Pica should not be diagnosed in such cases.
Boundary with other mental, behavioural and neurodevelopmental disorders
Individuals with anorexia nervosa may eat non-nutritive substances (e.g. tissues, paper) in order
to suppress hunger. In trichotillomania (hair-pulling disorder) or excoriation (skin-picking)
disorder, individuals sometimes eat hair or skin that they pull or pick from the body. Eating of
non-nutritive substances may also occur in other mental, behavioural or neurodevelopmental
disorders such as autism spectrum disorder and schizophrenia. In all such cases, an additional
diagnosis of pica should be assigned only if the behaviour is persistent or severe enough to require
clinical attention. That is, the behaviour causes damage to health, impairment in functioning or
significant risk due to the frequency, amount or nature of the substances or objects ingested.
Rumination-regurgitation disorder
Essential (required) features
• The intentional and repeated bringing up of previously swallowed food back to the mouth
(regurgitation), which may be re-chewed and re-swallowed (rumination), or may be
deliberately spat out (but not as in vomiting), is required for diagnosis.
• The regurgitation behaviour is frequent (at least several times per week) and sustained over
a period of at least several weeks.
• The diagnosis should only be assigned to individuals who have reached a developmental
age of at least 2 years.
6B85
Feeding and eating disorders | Rumination-regurgitation disorder
417
Feeding and eating disorders
• The regurgitation behaviour is not a manifestation of another medical condition that
directly causes regurgitation (e.g. oesophageal strictures or neuromuscular disorders
affecting oesophageal functioning) or causes nausea or vomiting (e.g. pyloric stenosis).
Additional clinical features
• In rumination-regurgitation disorder, the regurgitation behaviour is intentional; for
example, individuals may contract the tongue or abdominal muscles or cough in order
to induce regurgitation. Individuals with rumination-regurgitation disorder are able to
regurgitate food with relative ease, and may derive some reduction of anxiety or pleasure
from the behaviour.
• Individuals with rumination-regurgitation disorder often experience shame and
embarrassment about the behaviour, and try to keep the behaviour a secret because they
recognize it as socially unacceptable.
• Individuals with rumination-regurgitation disorder are often reluctant to seek treatment.
The disorder may persist for a very long duration if left untreated.
Course features
• Rumination-regurgitation disorder is slightly more prevalent among individuals with
disorders of intellectual development and autism spectrum disorder, whereby it may serve
a self-soothing or self-stimulating function.
• Rumination-regurgitation disorder may be chronic or continuous, or it may be episodic.
In episodic cases, the behaviour may be associated with stress or anxiety.
• Adolescents and adults may be less likely to re-chew the regurgitated food, and older adults
may choose to swallow or spit out the material depending on the social situation.
Developmental presentations
• Onset of rumination-regurgitation disorder may occur across early and later childhood,
adolescence and adulthood.
• Rumination-regurgitation disorder can create a substantial risk of choking in very young
children due to their inability to control their swallowing.
Feeding and eating disorders | Rumination-regurgitation disorder

109 - 6B8Y Other specified feeding and eating disor
6B8Y Other specified feeding and eating disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Culture-related features
• Induced vomiting may be part of some yogic practices, and should not be considered a
sign of the disorder unless the vomiting exceeds cultural norms and is associated with
distress or impairment.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with infant rumination syndrome
Rumination-regurgitation disorder should not be diagnosed in infants. Similar phenomena in
infants should be diagnosed as infant rumination syndrome in the grouping of functional digestive
disorders of infants, toddlers or children in Chapter 13 on diseases of the digestive system.
Boundary with self-induced vomiting
Rumination-regurgitation disorder should be distinguished from self-induced vomiting.
Self-induced vomiting may occur as a part of the presentation of anorexia nervosa, binge-purge
pattern, or bulimia nervosa. Self-induced vomiting may also occur as a culturally sanctioned
practice (e.g. among practitioners of yoga) that is not associated with a mental disorder.
Boundary with psychogenic vomiting
The differentiation from what has been considered to be “psychogenic vomiting”, or vomiting
as a somatoform expression of distress – particularly in South Asia – is based on the fact that
regurgitation in rumination-regurgitation disorder is typically volitional and intentional. If there
is evidence that “psychogenic vomiting” is voluntary, a diagnosis of rumination-regurgitation
disorder may be appropriate.
Other specified feeding and eating disorder
Essential (required) features
• The presentation is characterized by abnormal eating or feeding behaviours.
• The symptoms do not fulfil the diagnostic requirements for any other disorder in the
feeding and eating disorders grouping.
6B8Y
Feeding and eating disorders | Other specified feeding and eating disorder

11 - Secondary parented categories in neurodevelop
Secondary-parented categories in neurodevelopmental disorders

110 - 6B8Z Feeding or eating disorder, unspecified
6B8Z Feeding or eating disorder, unspecified
419
Feeding and eating disorders
• The symptoms are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. a primary psychotic disorder, a mood disorder or an
obsessive-compulsive or related disorder).
• The symptoms or behaviours are not developmentally appropriate or culturally sanctioned.
• The symptoms or behaviours are not a manifestation of another medical condition that
affects feeding or eating, are not better accounted for by another mental disorder, and
are not due to the effects of a substance or medication on the central nervous system,
including withdrawal effects.
• The symptoms or behaviours result in significant risk or damage to health, significant
distress, or significant impairment in personal, family, social, educational, occupational or
other important areas of functioning.
Feeding or eating disorder, unspecified
6B8Z
Feeding and eating disorders | Feeding or eating disorder, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

111 - Elimination disorders
Elimination disorders

112 - 6C00 Enuresis
6C00 Enuresis
421
Elimination disorders
6C00
6C01
Encopresis
6C0Z
Elimination disorder, unspecified.
Elimination disorders
Enuresis
Elimination disorders include the repeated voiding of urine into bed or clothes (enuresis) and
the repeated passage of faeces in inappropriate places (encopresis). These conditions occur in
individuals at a developmental age when urinary and faecal continence is ordinarily expected to
have been achieved, and may be voluntary or involuntary.
Elimination disorders include the following:
Enuresis
Essential (required) features
• Repeated and persistent voiding of urine into bed or clothes (e.g. several times per week
over several months), which may occur during the day or at night, is required for diagnosis.
• The individual has reached a developmental age when urinary continence is ordinarily
expected (approximately equivalent to a chronological age of 5 years).
• The symptoms are not better accounted for by the physiological effects of a substance
or medication, or by another medical condition that causes polyuria or urgency (e.g. a
urinary tract infection, untreated diabetes mellitus, a neurogenic bladder, a disease of the
nervous system, a disease of the musculoskeletal system or connective tissue, congenital or
acquired abnormalities of the urinary tract).
Note: The symptom category MF50.2 Urinary incontinence or one of its subcategories from
Chapter 21 on symptoms, signs or clinical findings, not elsewhere classified, may be considered
when the presentation does not meet the diagnostic requirements for enuresis. The diagnosis for
any underlying medical condition believed to be causing the urinary incontinence should also
be assigned.
6C00
Elimination disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Specifiers for nocturnal or diurnal occurrence
Nocturnal enuresis
• Inappropriate voiding of urine occurs only during the night. This is the most common
form of enuresis, and typically occurs during the first part of the night soon after the
individual has gone to sleep.
Diurnal enuresis
• Inappropriate voiding of urine occurs only during waking hours. This form of enuresis is
also referred to as “urinary incontinence”.
Nocturnal and diurnal enuresis
• Inappropriate voiding of urine occurs both during the night and during waking hours.
Enuresis, unspecified
Additional clinical features
• Voiding of urine is typically involuntary but, in some cases, may appear to be voluntary.
The diagnosis can be assigned in either case.
• Voiding of urine during sleep may take place during rapid eye movement (REM) sleep,
leading some individuals to report having dreamt of urinating.
• Diurnal enuresis may occur in children who avoid urination due to social anxiety about
using a public bathroom or due to refusal to cease an activity that is enjoyable (e.g. playing
a game).
• Enuresis may lead to the development of psychological problems due to associated distress
or stigma. Enuresis may be an aspect of another mental, behavioural or neurodevelopmental
disorder, or both enuresis and another emotional/behavioural disturbance may arise in
parallel due to related etiological factors. A diagnosis of enuresis may be assigned together
with other mental, behavioural or neurodevelopmental disorder diagnoses if the enuresis
is a distinct focus of clinical attention.
6C00.0
6C00.1
6C00.2
6C00.Z
Elimination disorders | Enuresis
423
Elimination disorders
• Enuresis is common among individuals with disorders of intellectual development.
The diagnosis should only be assigned if all diagnostic requirements of enuresis are met,
and the individual’s developmental age is equivalent to that at which urinary continence in
normally expected (approximately equivalent to a chronological age of 5 years).
• Enuresis can occur among individuals with neurocognitive disorders (e.g. dementia).
The additional diagnosis of enuresis can be assigned if all diagnostic requirements are met,
and the condition requires separate clinical attention.
• Enuresis is more common among children with a parent who has a history of enuresis.
Boundary with normality (threshold)
• It is not uncommon for children to experience occasional urinary incontinence up until
middle childhood.
Course features
• Most children establish urinary control by adolescence, with a small number of individuals
continuing to experience enuresis into adulthood.
• Enuresis that persists into adolescence is often associated with an increase in frequency of
urinary voiding episodes.
Developmental presentations
• Enuresis may have been present from birth (i.e. an atypical extension of normal infantile
incontinence), or may have its onset following a period of acquired bladder control.
• The common age of onset for children who have previously acquired urinary continence
yet develop enuresis is between 5 and 8 years.
• Diurnal enuresis is less prevalent among children over the age of 9 years.
Culture-related features
• Cultural variation exists with regard to toilet training. Expectations regarding the age
when continence occurs and whether enuresis is viewed as pathological vary by cultural
group. Cultural norms may affect tolerance for the behaviours, expectations regarding
their course, and the associated level of shame and stigma.
Elimination disorders | Enuresis

113 - 6C01 Encopresis
6C01 Encopresis
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Nocturnal enuresis is more prevalent among males, whereas diurnal enuresis is more
prevalent among females.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with the effects of substances including medications
Enuresis may occur due to certain antipsychotic medications, diuretics or other substances or
medications that stimulate incontinence. In these cases, incontinence should be considered a
side-effect, and a diagnosis of enuresis is typically not warranted. If the enuresis was present
before administration of medication, it may be appropriate to assign a diagnosis.
Boundary with other medical conditions
Enuresis should not be diagnosed if the symptoms are better accounted for by another medical
condition that causes polyuria or urgency. A diagnosis of enuresis may be warranted if the
urinary incontinence was present before the other medical condition developed, or persists after
the individual has received treatment.
Encopresis
Essential (required) features
• Repeated and persistent passage of faeces in inappropriate places (e.g. at least once per
month over a period of several months) is required for diagnosis.
• The individual has reached the developmental age when faecal continence is ordinarily
expected (approximately equivalent to a chronological age of 4 years).
• Faecal soiling is not better accounted for by the physiological effects of a substance (e.g.
excessive use of laxatives) or another medical condition (e.g. aganglionic megacolon, spina
bifida, anal stenosis, chronic diarrhoea, congenital or acquired abnormalities of the bowel
or gastrointestinal infection).
Note: The symptom category ME07 Faecal incontinence or one of its subcategories from Chapter
21 on symptoms, signs or clinical findings, not elsewhere classified, may be considered when
the presentation does not meet the diagnostic requirements for encopresis. The diagnosis for
any underlying medical condition believed to be causing the faecal incontinence should also
be assigned.
6C01
Elimination disorders | Encopresis
425
Elimination disorders
Elimination disorders | Encopresis
Specifiers for the presence of constipation and overflow
Encopresis with constipation and overflow incontinence
• Encopresis with constipation and overflow incontinence is the most common form of
faecal soiling, and is characterized by retention and impaction of faeces. Stools are typically
– but not always – poorly formed (loose or liquid), and leakage may range from occasional
to continuous.
• There is often a history of toilet avoidance leading to constipation.
Encopresis without constipation and overflow incontinence
• Encopresis without constipation and overflow incontinence is not associated with retention
and impaction of faeces but rather is characterized by reluctance, resistance or failure
to conform to social norms in defecating in acceptable places in the context of normal
physiological control over defecation.
• Stools are typically of normal consistency, and inappropriate defecation is likely to
be intermittent.
Encopresis, unspecified
Additional clinical features
• Encopresis is most often involuntary but, in some cases, may appear to be voluntary.
The diagnosis can be assigned in either case. Involuntary passage of faeces is most often
associated with encopresis with constipation and overflow incontinence.
• Encopresis that is intentional may be associated with oppositional defiant disorder or
conduct-dissocial disorder.
• Stool withholding, or retentive behaviours, may be the result of avoidance of bowel
movements, especially in those individuals with a history of difficulty or pain in passing
stools. Individuals with chronic constipation and stool retention may go on to develop
acquired megacolon.
• Specific phobias or social anxiety disorder (e.g. fear of using public bathrooms) may also
contribute to retentive behaviours.
• Encopresis is common among individuals with disorders of intellectual development.
The diagnosis should only be assigned if all diagnostic requirements are met, and the
individual’s developmental age is equivalent to that at which faecal continence in normally
expected (approximately equivalent to a chronological age of 4 years).
6C01.0
6C01.1
6C01.Z
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Encopresis can occur among individuals with neurocognitive disorders (e.g. dementia).
The additional diagnosis of encopresis can be assigned if all diagnostic requirements are
met, and the condition requires separate clinical attention.
• Individuals diagnosed with encopresis may experience embarrassment and reduced selfesteem. Older children diagnosed with encopresis may experience impairments in social
functioning due to peer teasing and possible social isolation. Furthermore, individuals
with encopresis may avoid social situations for fear of passing faeces in the presence of
other people.
• Individuals with encopresis and chronic constipation may also experience co-occurring
symptoms of enuresis. Both diagnoses may be assigned if the full diagnostic requirements
for each are met.
Boundary with normality (threshold)
• It is not uncommon for children to experience an occasional soiling accident during
early childhood. Faecal incontinence must occur frequently and persistently to warrant
a diagnosis.
Course features
• Encopresis can persist for years, with recurrent episodes of worsening symptoms.
Developmental presentations
• Faecal incontinence may have been present from birth (i.e. an atypical extension of normal
infantile incontinence), or may have its onset following a period of acquired bowel control.
• Encopresis has a high prevalence (between 1.5% and 7.5%) among school-aged children
between the ages of 6 and 12 years.
Sex- and/or gender-related features
• Encopresis is more prevalent among males.
• Females may be more likely to experience urinary tract infections co-occurring with
encopresis due to contamination of the urethra with faecal bacteria.
Elimination disorders | Encopresis

114 - 6C0Z Elimination disorder, unspecified
6C0Z Elimination disorder, unspecified
427
Elimination disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with the effects of substances including medications
Faecal incontinence may occur due to certain medications including some antibiotics, some
cancer medications, laxatives and antacids that contain magnesium. In these cases, a diagnosis
of encopresis is typically not warranted. If the encopresis was present before administration of
medication, it may be appropriate to assign a diagnosis.
Boundary with other medical conditions
Encopresis should not be diagnosed if the symptoms are better accounted for by another medical
condition that causes faecal incontinence. A diagnosis of encopresis may be warranted if the
faecal incontinence was present before the other medical condition developed, or persists after
the individual has received adequate treatment.
Elimination disorder, unspecified
6C0Z
Elimination disorders | Elimination disorder, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

115 - Disorders of bodily distress or bodily experi
Disorders of bodily distress or bodily experience

116 - 6C20 Bodily distress disorder
6C20 Bodily distress disorder
429
Disorders of bodily distress or bodily experience
6C20
6C21
Body integrity dysphoria
Disorders of bodily distress
or bodily experience
Bodily distress disorder
6C2Y
Other specified disorder of bodily distress or bodily
experience
6C2Z
Disorder of bodily distress or bodily experience,
unspecified.
Disorders of bodily distress or bodily experience are characterized by disturbances in the person’s
experience of their body. Bodily distress disorder involves bodily symptoms that the individual
finds distressing, and to which excessive attention is directed. Body integrity dysphoria involves
a disturbance in the person’s experience of the body manifested in the persistent desire to
have a specific physical disability, accompanied by persistent discomfort or intense feelings of
inappropriateness concerning current non-disabled body configuration.
Bodily distress disorder
Essential (required) features
• The presence of bodily symptoms that are distressing to the individual is required for
diagnosis. Typically, this involves multiple bodily symptoms that may vary over time.
Occasionally, the focus is limited to a single symptom – usually pain or fatigue.
6C20
Disorders of bodily distress or bodily experience | Bodily distress disorder
Disorders of bodily distress or bodily experience include the following:
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Excessive attention is directed towards the symptoms, which may manifest in:
• persistent preoccupation with the severity of the symptoms or their negative
consequences – in individuals who have an established medical condition that may be
causing or contributing to the symptoms, a degree of attention related to the symptoms
that is clearly excessive in relation to the nature and severity of the medical condition;
• repeated contacts with health-care providers related to the bodily symptoms that are
substantially in excess of what would be considered medically necessary.
• Excessive attention to the bodily symptoms persists, despite appropriate clinical
examination and investigations or appropriate reassurance from health-care providers.
• Bodily symptoms are persistent; that is, some symptoms are present (although not
necessarily the same symptoms) on most days during a period of at least several months
(e.g. 3 months or more).
• The bodily symptoms and related distress and preoccupation result in significant
impairment in personal, family, social, educational, occupational or other important areas
of functioning.
• The symptoms or the associated distress and preoccupation are not better accounted for
by another mental disorder (e.g. schizophrenia or another primary psychotic disorder, a
mood disorder, or an anxiety or fear-related disorder).
Severity of bodily distress disorder
The severity of bodily distress disorder should be classified based on the degree of distress
or preoccupation with bodily symptoms, the persistence of the disorder and the degree of
impairment. The clinician should make a global determination of the appropriate rating
of severity based on the overall clinical presentation, and select one of the following
subcategories.
Mild bodily distress disorder
• All the essential features of bodily distress disorder are present.
• Although there is excessive attention to distressing symptoms and their consequences,
which may result in frequent medical visits, the individual spends only a limited amount
of time focusing on them (e.g. no more than 1 or 2 hours per day), and is able to focus on
other unrelated topics.
• The bodily symptoms and related distress and preoccupation result in mild impairment in
personal, family, social, educational, occupational or other important areas of functioning
(e.g. strain in relationships, less effective academic or occupational functioning,
abandonment of specific leisure activities).
Moderate bodily distress disorder
• All the essential features of bodily distress disorder are present.
• Persistent preoccupation with the distressing symptoms and their consequences is typically
6C20.0
6C20.1
Disorders of bodily distress or bodily experience | Bodily distress disorder
431
Disorders of bodily distress or bodily experience
associated with frequent medical visits. The individual devotes a substantial amount of
time and energy to focusing on the symptoms and their consequences (e.g. several hours
per day).
• The bodily symptoms and related distress and preoccupation result in moderate
impairment in personal, family, social, educational, occupational or other important areas
of functioning (e.g. relationship conflict, performance problems at work, abandonment of
a range of social and leisure activities).
Severe bodily distress disorder
• All the essential features of bodily distress disorder are present.
• The presentation is characterized by a pervasive and persistent preoccupation with the
distressing symptoms and their consequences, and a narrowing of interests such that
the bodily symptoms and their consequences become the nearly exclusive focus of the
individual’s life, typically resulting in extensive interactions with the health-care system.
• The bodily symptoms and related distress and preoccupation result in severe impairment in
personal, family, social, educational, occupational or other important areas of functioning
(e.g. unable to work, alienation of friends and family, abandonment of nearly all social and
leisure activities).
Bodily distress disorder, unspecified
Additional clinical features
• The most common bodily symptoms associated with bodily distress disorder include
pain (e.g. musculoskeletal pain, backache, headaches), fatigue, and gastrointestinal and
respiratory symptoms, although patients may be preoccupied with any bodily symptoms.
The individual can generally provide a detailed description of the symptoms, but it may be
difficult for clinicians to account for the symptoms in anatomical or physiological terms.
• Individuals with bodily distress disorder often over-interpret or catastrophize about their
bodily symptoms, and dwell on their most extreme negative consequences. For example,
in more severe cases, pain or fatigue may be perceived as being so intense that they prevent
normal activities, despite there being no medical basis for such a belief. This is often
accompanied by fear of triggering pain or an exacerbation of other symptoms, which may
lead to undue avoidance of activities; this may in turn lead to other symptoms associated
with inactivity (e.g. stiffness and muscle weakness, muscle pain following minimal
exertion).
• Individuals with bodily distress disorder may hold a range of attributions regarding their
symptoms, including psychological and physical explanations. As severity increases,
affected individuals are more likely to reject psychological explanations for their symptoms.
Some individuals with bodily distress disorder believe that their bodily symptoms indicate
underlying physical illness or injury (i.e. disease conviction), even though this has not
been detected. Insistence that the symptoms are caused by an undiagnosed illness or
6C20.2
6C20.Z
Disorders of bodily distress or bodily experience | Bodily distress disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
injury may result in multiple medical tests and procedures. This pattern is most common
in individuals with severe bodily distress disorder, who may have long and complicated
histories of contact with both primary and specialist medical services, during which many
negative investigations or fruitless operations across various body systems may have been
carried out.
• Individuals with bodily distress disorder most often present in general medical settings
rather than for mental health services. They may be reluctant to agree that there is a
psychological component to their experience, and may react negatively to the suggestion
of a referral to a mental health professional.
• Individuals with bodily distress disorder often express dissatisfaction with the medical
care they have received previously, and may change health-care providers frequently.
• In communities with limited access to health care, individuals with bodily distress disorder
may not have extensive interactions with the formal health-care system, but they may seek
care from alternative sources.
• Bodily distress disorder often occurs in the context of comorbid medical conditions and
co-occurring mental disorders – especially depressive disorders and anxiety and fearrelated disorders.
Boundary with normality (threshold)
• The experience of bodily symptoms and occasional concern about them is normal. However,
people with bodily distress disorder report greater distress about their bodily symptoms
than would generally be regarded as proportional to the nature of the symptoms, and their
excessive attention to their symptoms is not alleviated by appropriate clinical examination
and investigations, and by reassurance from health-care providers.
• Individuals with bodily distress disorder who have a comorbid medical condition that
may be causing or contributing to the bodily symptoms exhibit greater preoccupation with
symptoms and greater functional impairment than those who have a medical condition that
is similar in nature and severity without concurrent bodily distress disorder. Furthermore,
the number of bodily symptoms reported often exceeds that usually associated with the
comorbid medical condition.
Course features
• In about half of individuals diagnosed with bodily distress disorder seen in primary care
settings, bodily symptoms resolve within 6–12 months. Individuals with severe disorder
and those with multiple bodily symptoms tend to experience a more chronic and persistent
course. The presence of multiple bodily symptoms is commonly associated with greater
impairment in functioning, as well as with poorer treatment response for any co-occurring
mental or medical conditions.
Disorders of bodily distress or bodily experience | Bodily distress disorder
433
Disorders of bodily distress or bodily experience
Developmental presentations
• Bodily distress disorder can occur across the lifespan. The most common bodily symptoms
in children and adolescents include recurrent gastrointestinal symptoms (e.g. abdominal
pain, nausea), fatigue, headaches and musculoskeletal pain. Children are more likely to
experience a single recurrent symptom rather than multiple bodily symptoms. School
absences due to symptoms are common. In severe cases, children may display regression
of behaviour and extreme impairment – for example, affecting self-care and mobility.
• In children and adolescents, parental or caregiver responses to symptoms can affect the
course and severity of bodily distress disorder, as well as whether medical attention is
sought. For example, excessive parental or caregiver concern can worsen the severity or
prolong the course of the disorder in children.
• Older adults with bodily distress disorder are more likely than younger adults with
the condition to have multiple bodily symptoms, and symptoms are more likely to be
persistent. The diagnosis of bodily distress disorder in older adults can be challenging due
to the higher likelihood of medical conditions that may account for symptoms, or that are
comorbid with bodily distress disorder.
Culture-related features
• Somatic symptoms are common in all cultural groups, especially among people seeking
health care. Differences in rates of bodily symptoms may be related to cultural reporting
styles. Differences may also reflect the organizational culture of the health-care system,
with somatic complaints more likely where clinical encounters are brief and the delivery of
services is less person-centred.
• Symptoms that are common in one cultural group may be less common in other groups.
For example, whereas pain symptoms are common across cultures, symptoms such as
heat in the body or in the head, crawling sensations, heaviness, or complaints of “gas” or
abdominal bloating are common in certain cultural group but not in others.
• Culture may influence explanatory models, with symptoms variously attributed to forms
of bodily energy, humours or other ethno-physiological concepts, as well as religious,
spiritual, personal, family or environmental stresses. Some specific attributions, such as
symptoms being caused by semen loss or kidney weakness, are common in certain cultural
group but not in others.
• Across cultural groups, people with multiple distressing bodily symptoms are likely to seek
health care, including from traditional or faith healers. However, help-seeking behaviour
is also substantially influenced by access to health-care services. Individuals may not have
extensive interactions with the formal health-care system because of limited opportunities
to access health care, which varies substantially by cultural group.
Disorders of bodily distress or bodily experience | Bodily distress disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Prevalence rates do not appear to differ by gender prior to puberty, after which prevalence
is higher in females.
• Symptom presentation may vary by gender, with women more likely to report multiple
bodily concerns.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with mood disorders
Among individuals with mood disorders, somatic symptoms may be the dominant aspects of
the clinical presentation – particularly in primary care settings. In addition, some individuals
with mood disorders may develop neurovegetative symptoms (e.g. weight loss, fatigue) or other
associated physical symptoms (e.g. pain), about which they become preoccupied. Bodily distress
disorder should be diagnosed only if the preoccupation with physical symptoms occurs outside
the context of mood episodes – for example, if the preoccupation precedes a depressive episode
or persists after the depressive episode has remitted.
Boundary with generalized anxiety disorder
Individuals with generalized anxiety disorder may report somatic symptoms about which they
are concerned (e.g. palpitations or gastric distress), but they also report concerns about negative
events occurring in several different aspects of everyday life (e.g. work, relationships, finance).
Unlike individuals with bodily distress disorder, individuals with generalized anxiety disorder
do not typically exhibit a preoccupation with bodily symptoms that persists despite medical
evaluation and reassurance. However, co-occurrence of bodily distress disorder and anxiety and
fear-related disorders is common, although individuals with bodily distress disorder are less likely
to endorse the psychological components of anxiety other than distress about their bothersome
symptoms.
Boundary with panic disorder
Panic disorder is characterized by recurrent, unexpected, self-limited episodes of intense fear
or apprehension with prominent somatic symptoms and feelings of an impending catastrophe
(e.g. fainting, having a stroke, heart attack or dying), with a sense of immediacy of the threat.
Individuals with panic disorder often become preoccupied with the transient somatic symptoms
they experience during panic attacks, and may express concern that they are dangerous and
suggestive of imminent harm. An additional diagnosis of bodily distress disorder should not be
assigned on the basis of concern about symptoms experienced during panic attacks. However, if
individuals with panic disorder are excessively attentive to or preoccupied by persistent somatic
symptoms that are distinct from those typically associated with panic attacks, and all diagnostic
requirements for both disorders are met, both diagnoses may be assigned.
Disorders of bodily distress or bodily experience | Bodily distress disorder

117 - 6C21 Body integrity dysphoria
6C21 Body integrity dysphoria
435
Disorders of bodily distress or bodily experience
Boundary with hypochondriasis (health anxiety disorder)
Unlike individuals with hypochondriasis, who are preoccupied with the possibility of having one
or more serious, progressive or life-threatening illnesses, individuals with bodily distress disorder
are typically preoccupied by the symptoms themselves and the impact of the symptoms on
their lives. Individuals with hypochondriasis may also seek medical attention, but their primary
purpose is to obtain reassurance that they do not have the feared serious medical condition.
Individuals with bodily distress disorder typically seek medical attention in order to get relief
from their symptoms, not to disconfirm the belief that they have a serious medical illness.
Boundary with factitious disorder imposed on self
Individuals with factitious disorder imposed on self may also present bodily symptoms. If the
presented symptoms have been feigned, falsified or intentionally induced or aggravated, factitious
disorder imposed on self rather than bodily distress disorder is the appropriate diagnosis.
Body integrity dysphoria
Essential (required) features
• An intense and persistent desire to become physically disabled in a significant way (e.g. a
major limb amputation, paraplegia, blindness) accompanied by persistent discomfort or
intense negative feelings about one’s current body configuration or functioning, is required
for diagnosis.
• The desire to be disabled results in harmful consequences, manifested in either or both of
the following:
• attempts to actually become disabled through self-injury, which have resulted in the
person putting their health or life in significant jeopardy;
• preoccupation with the desire to be disabled, resulting in significant impairment in
personal, family, social, educational, occupational or other important areas of functioning
(e.g. avoidance of close relationships, interference with work productivity).
• Onset of the persistent desire to be disabled occurs by early adolescence.
• The disturbance is not better accounted for by another mental disorder (e.g. schizophrenia
or another primary psychotic disorder – in which, for example, a delusional conviction
that the limb belongs to another person may be present – or factitious disorder) or by
malingering.
• The symptoms or behaviours are not better accounted for by gender incongruence, by a
disease of the nervous system or by another medical condition.
6C21
Disorders of bodily distress or bodily experience | Body integrity dysphoria
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• It is common for individuals to describe their discomfort in terms of feeling like they
should have been born with the desired disability (e.g. missing a leg).
• Most individuals with this condition exhibit associated “pretending” or simulation
behaviour (e.g. binding one’s leg to simulate being a person with a limb amputation, or
using a wheelchair or crutches), which is often the first manifestation of the condition.
These behaviours are usually done in secret. The need for secrecy may result in avoidance
or termination of intimate relationships that would interfere with opportunities
for simulation.
• Some individuals who attempt to make themselves disabled through self-injury try to
cover up the self-inflicted nature of the attempt by making it look like an accident.
• Many individuals with body integrity dysphoria have a sexual component to their desire
– either being sexually attracted to individuals with certain disabilities or being intensely
sexually aroused at the thought of being disabled.
• Shame about the desire to be disabled is common in individuals with body integrity
dysphoria, and most individuals keep this desire a closely guarded secret because of a fear
of being rejected or thought to be “crazy” by others. It is common for the family, friends,
co-workers and even their partners or spouses of individuals with body integrity dysphoria
to be unaware of their desire. Some may seek treatment for associated depressive or other
symptoms and yet not share their desire to be disabled with their health-care provider.
• It is assumed that most individuals with body integrity dysphoria never come to clinical
attention. When they do, it is generally as adults – often when they seek the assistance
of a health-care professional to relieve their distress, to help them actualize their desired
disability, or because they have injured themselves in an attempt to become disabled.
Boundary with normality (threshold)
• Some individuals, especially children and adolescents, may have time-limited periods in
which they pretend to have a disability such as blindness out of curiosity about what it is
like to live as a disabled person. Such individuals do not experience a persistent desire to
become disabled or the harmful consequences associated with body integrity dysphoria.
Course features
• The typical course is for the intensity of the desire to become disabled and consequent
functional impairment to wax and wane. There may be periods of time where the intensity
of the desire and the accompanying dysphoria is so great that the individual can think of
Disorders of bodily distress or bodily experience | Body integrity dysphoria
437
Disorders of bodily distress or bodily experience
nothing else, and may make plans or take action to become disabled. At other times, the
desire to become disabled and the associated intense negative feelings abate, although at
no time does it completely cease to be present.
Developmental presentations
• The onset of body integrity dysphoria is most commonly in early to mid-childhood,
although some cases have their onset in adolescence. The first manifestation is typically
the child pretending to have the desired disability, often in secret.
Culture-related features
• Although apparently quite rare, cases have been reported in many different countries
and cultures.
Sex- and/or gender-related features
• Among those who come to clinical attention, prevalence appears to be higher among males.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizophrenia, other primary psychotic disorders, and other mental
disorders with psychotic symptoms
Somatic delusions may involve the conviction that a part of the person’s body does not belong
to them. In such cases, a diagnosis of schizophrenia or another primary psychotic disorder, or a
mood disorder with psychotic symptoms should be considered. Individuals with body integrity
dysphoria do not harbour false beliefs about external reality related to their desire to be disabled,
and thus are not considered to be delusional. Instead, they experience an internal feeling that they
would be “right” only if they were disabled.
Boundary with obsessive-compulsive disorder
Obsessive-compulsive disorder is characterized by repetitive and persistent thoughts, images or
urges that are experienced as intrusive and unwanted (ego-dystonic). In contrast, the repetitive
Disorders of bodily distress or bodily experience | Body integrity dysphoria
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
thoughts, images and impulses related to the desire to become disabled in body integrity
dysphoria (e.g. fantasies of being disabled) are ego-syntonic, and are not experienced as intrusive,
unwanted or distressing. Distress in body integrity dysphoria is typically related to not being able
to actualize the disability, or to fear of the negative judgements of others.
Boundary with body dysmorphic disorder
Individuals with body dysmorphic disorder have persistent preoccupations about a part of their
body that they believe is defective, or a perception that their appearance overall is ugly. In contrast,
individuals with body integrity dysphoria are persistently preoccupied with a sense that the way
their body is configured (e.g. for those who desire an amputation) or functions (e.g. for those who
want to be paraplegic or blind) is wrong, unnatural and not as it should be.
Boundary with paraphilic disorder involving solitary behaviour or consenting
individual
Some individuals have a paraphilic focus of intense sexual arousal involving the fantasy of
having a serious disability, which may be associated with transient periods of wanting to acquire
the disability that is the source of arousal. If the desire to acquire a disability occurs solely in
connection with sexual arousal, body integrity dysphoria should not be diagnosed. A diagnosis
of paraphilic disorder involved solitary behaviour or consenting individuals may be appropriate
in such cases, if the individual is markedly distressed about this arousal pattern or if they have
injured themselves as a part of enacting sexual fantasies related to it.
Boundary with factitious disorder and malingering
Individuals with body integrity disorder often simulate their desired disability as a way of
reducing their negative feelings (e.g. a person who desires to be paraplegic may spend part or all
of their time using a wheelchair). Moreover, they typically shun medical attention. In contrast,
individuals with factitious disorder feign medical or psychological signs or symptoms in order to
seek attention – especially from health-care providers – and to assume the sick role. Malingering
is characterized by feigning of medical or psychological signs or symptoms for obvious external
incentives (e.g. disability payments).
Boundary with diseases of the nervous system
Some diseases of the nervous system may cause symptoms that involve profound changes in the
person’s attitude towards and experience of their own bodies (e.g. somatoparaphrenia, in which
a paralysed body part is experienced as alien or as belonging to someone else.) If the persistent
discomfort about the individual’s body configuration is better accounted for by a disease of the
nervous system, then body integrity dysphoria should not be diagnosed.
Disorders of bodily distress or bodily experience | Body integrity dysphoria

118 - 6C2Y Other specified disorder of bodily distr
6C2Y Other specified disorder of bodily distress or bodily experience

119 - 6C2Z Disorder of bodily distress or bodily ex
6C2Z Disorder of bodily distress or bodily experience, unspecified
439
Disorders of bodily distress or bodily experience
Other specified disorder of bodily distress or bodily experience
Essential (required) features
• The presentation is characterized by disturbances in the person’s experience of their
body that share primary clinical features with other disorders of bodily distress or bodily
experience (e.g. distressing bodily symptoms to which excessive attention is directed, or
intense feelings of inappropriateness concerning one’s body configuration or functioning).
• The symptoms do not fulfil the diagnostic requirements for any other disorder in the
disorders of bodily distress or bodily experience grouping.
• The symptoms are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. a mood disorder, schizophrenia or another primary
psychotic disorder, an eating disorder).
• The symptoms have persisted for at least several months.
• The symptoms or behaviours are not developmentally appropriate (e.g. focused on bodily
changes during puberty) or culturally sanctioned.
• The symptoms or behaviours are not accounted for by gender incongruence or by another
medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning.
Disorder of bodily distress or bodily experience, unspecified
6C2Y
6C2Z
Disorders of bodily distress or bodily experience | Other specified disorder of bodily distress or bodily experience
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

12 - 8A05.0 Primary tics and tic disorders
8A05.0 Primary tics and tic disorders
153
Neurodevelopmental disorders
Other specified neurodevelopmental disorder
Essential (required) features
• The presentation is characterized by significant difficulties in the acquisition and execution of
specific intellectual, motor, language or social functions that arise during the developmental
period and share primary clinical features with other neurodevelopmental disorders.
• The symptoms do not fulfil the diagnostic requirements for any other disorder in the
neurodevelopmental disorders grouping.
• The symptoms are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. a psychotic disorder, a mood disorder, a disorder
specifically associated with stress).
• The symptoms or behaviours are not developmentally typical and are not entirely
attributable to external factors, such as economic or environmental disadvantage or lack of
access to educational opportunities.
• The symptoms or behaviours are not a manifestation of another medical condition that
is not classified under mental and behavioural disorders, and are not due to the effects
of a substance (e.g. alcohol) or medication (e.g. bronchodilators) on the central nervous
system, including withdrawal effects.
• The difficulties result in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning.
Neurodevelopmental disorder, unspecified
Secondary-parented categories in neurodevelopmental disorders
Primary tics and tic disorders
The following categories – Tourette syndrome, chronic motor tic disorder and chronic phonic tic
disorder – are classified in the grouping of primary tics and tic disorders in Chapter 8 on diseases
of the nervous system, but are cross-listed here because of their high co-occurrence and familial
association with neurodevelopmental disorders.
6A0Y
6A0Z
8A05.0
Neurodevelopmental disorders | Other specified and unspecified neurodevelopmental disorder

120 - Disorders due to substance use or addictive b
Disorders due to substance use or addictive behaviours

121 - Disorders due to substance use
Disorders due to substance use
441
Disorders due to substance use or addictive behaviours
Disorders due to substance
use or addictive behaviours
Disorders due to substance use
Disorders due to substance use include disorders that result from a single occasion or repeated
use of substances that have psychoactive properties, including certain medications. Disorders
related to 14 classes or groups of psychoactive substances that have important clinical and public
health consequences are included, and categories are also available for other specified substances.
Typically, initial use of these substances produces pleasant or appealing psychoactive effects that
are rewarding, and this response is reinforced with repeated use. With continued use, many of the
substances included here have the capacity to produce dependence. They also have the potential
to cause numerous forms of harm – to both mental and physical health. Disorders due to harmful
nonmedical use of non-psychoactive substances (e.g. laxatives, growth hormone, erythropoietin
and non-steroidal anti-inflammatory drugs) are also included in this grouping.
General cultural considerations for disorders due to substance use
• Use of psychoactive substances is influenced by strong cultural meanings and traditions,
which may affect the risk of development of a disorder due to substance use. The cultural
milieu in which the substance is used should be considered when determining risk and
the presence or absence of pathology. For example, substances may be used regularly as
part of religious rituals, celebrations (e.g. New Year’s Eve), culturally sanctioned mystical
experiences, specific events (e.g. wakes preceding funerals) or healing activities without
resulting in a disorder due to substance use.
• Cultural values and interpretations related to the use of psychoactive substances in
specific communities, and cultural terms used to describe the substance and its effects,
vary greatly across cultures. Knowledge of specific terms and interpretations will improve
communication with patients and determination of possible disorder. For example,
American Indians who use peyote during traditional worship ceremonies may consider
the substance a sacrament rather than a drug.
Disorders due to substance use or addictive behaviours

122 - Substance classes
Substance classes

123 - 6C40 Disorders due to use of alcohol
6C40 Disorders due to use of alcohol
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Local availability of a substance affects the prevalence of disorders associated with it. For
example, prevalence of alcohol dependence is lower in predominantly Muslim countries
due to the religious prohibitions against alcohol consumption.
• Immigration may affect an individual’s pattern of substance as a result of changes in culture,
including gender roles. Such changes can lead to higher or lower risk of disorders due to
substance use depending on the characteristics of the sending and receiving societies, the
circumstances of migration, and the relative social position in each setting. For example,
immigrants moving from a society with high alcohol consumption to one with low alcohol
consumption tend to assume the lower risk of disorder of the host country.
Substance classes
Disorders due to substance use are classified by first identifying the substance used. Available
substance classes included are listed below, with a brief description of their properties, typical
preparations and methods of use, as well as associated harms and disorders.
Disorders due to use of alcohol
Disorders due to use of alcohol are characterized by the pattern and consequences of alcohol
use. Alcohol – more specifically termed ethyl alcohol or ethanol – is an intoxicating compound
produced by fermentation of sugars, usually in agricultural products such as fruits, cereals and
vegetables, with or without subsequent distillation. There are a wide variety of alcoholic drinks,
with alcohol concentrations typically ranging from 1.5% to 60%. Alcohol is predominantly a
central nervous system depressant. Unlike most other substances, elimination of alcohol from
the body occurs at a constant rate, such that its clearance follows a linear rather than a logarithmic
course. In addition to ability to produce alcohol intoxication, alcohol has dependence-producing
properties, resulting in alcohol dependence in some people and alcohol withdrawal when alcohol
use is reduced or discontinued.
Alcohol is implicated in a wide range of harms affecting most organs and systems of the body
(e.g. cirrhosis of the liver, gastrointestinal cancers, pancreatitis). Harm to others resulting from
behaviour during alcohol intoxication is well recognized, and is included in the definitions of
categories of harmful use of alcohol (i.e. episode of harmful use of alcohol and harmful pattern
of use of alcohol). Several alcohol-induced mental disorders (e.g. alcohol-induced psychotic
disorder) and alcohol-related forms of neurocognitive impairment (e.g. dementia due to use of
alcohol) are also recognized.
Alcohol use is one of the most common causes of premature death and illness among men, and
is still a substantial – though less common – cause of premature death and illness among women.
The use of alcohol is implicated in millions of deaths per year (e.g. due to motor vehicle accidents).
Although alcohol is used worldwide, and its use is legal among adults in most countries, there are
substantial differences in cultural and religious acceptability of its use. Consequently, prevalence
6C40
Disorders due to substance use or addictive behaviours | Substance classes

124 - 6C41 Disorders due to use of cannabis
6C41 Disorders due to use of cannabis

125 - 6C42 Disorders due to use of synthetic cannab
6C42 Disorders due to use of synthetic cannabinoids
443
Disorders due to substance use or addictive behaviours
of alcohol use disorders shows substantial regional variation; the highest prevalence is observed
in eastern Europe and the lowest in Africa. Low prevalence of alcohol use in some countries is
related to lower rates of disorders due to use of alcohol.
Polymorphisms of the genes for the alcohol-metabolizing enzymes alcohol dehydrogenase
(ADH1B) and aldehyde dehydrogenase, which affect the response to alcohol, are seen more
frequently among East Asians than other groups. Individuals with certain polymorphisms may
develop facial flushing and palpitations when consuming alcohol, which may be so severe as to
preclude alcohol consumption and thus lower the risk of alcohol use disorder.
Disorders due to use of cannabis
Disorders due to use of cannabis are characterized by the pattern and consequences of cannabis
use. Cannabis is the collective term for a range of psychoactive preparations of the cannabis
plant, Cannabis sativa, and related species and hybrids. Cannabis contains cannabinoids,
a class of diverse chemical compounds that act on endogenous cannabinoid receptors that
modulate neurotransmitter release in the brain. The principal psychoactive cannabinoid is
δ-9-tetrahydrocannabinol (THC). Cannabis is typically smoked in the form of the flowering heads
or leaves of the marijuana plant; tobacco is often mixed with cannabis when smoked. Cannabis
oils are also prepared from these same sources. These preparations vary considerably in their
THC potency. Cannabis has predominantly central nervous system depressant effects; it produces
a characteristic euphoria that may be part of the presenting features of cannabis intoxication,
which may also include impairment in cognitive and psychomotor functioning. Cannabis
has dependence-producing properties resulting in cannabis dependence in some people and
cannabis withdrawal when use is reduced or discontinued. Cannabis is associated with a range of
cannabis-induced mental disorders. Other medical conditions are also associated with cannabis
use, including some respiratory and cardiovascular diseases.
Cannabis is the most commonly used illicit drug worldwide, but its legal status varies considerably;
in certain countries it is legally available for medicinal or personal use. Acceptance of cannabis
use for recreational or medical purposes also varies widely by culture. Variations in legal status
and cultural acceptability are related to differential consequences for detection of use (e.g. arrest,
school suspension or employment suspension), affecting the probability that the person may
seek treatment.
Disorders due to use of synthetic cannabinoids
Disorders due to use of synthetic cannabinoids are characterized by the pattern and consequences
of synthetic cannabinoid use. Synthetic cannabinoids are synthesized diverse chemical
compounds that are potent agonists for endogenous cannabinoid receptors. There are several
hundred such compounds. The synthetic compound is typically sprayed onto a vehicle such as
cannabis or tea leaves and then smoked. The effect of these compounds is distinctly different from
smoking naturally cultivated cannabis, in that the euphoric effects are typically accompanied
or dominated by psychotic-like symptoms (e.g. paranoia, hallucinations and disorganized
6C41
6C42
Disorders due to substance use or addictive behaviours | Substance classes

126 - 6C43 Disorders due to use of opioids
6C43 Disorders due to use of opioids

127 - 6C44 Disorders due to use of sedatives, hypno
6C44 Disorders due to use of sedatives, hypnotics or anxiolytics
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
behaviour). Synthetic cannabinoid intoxication may therefore present more frequently with
psychotic symptoms in addition to the more typical effects of cannabis. Synthetic cannabinoids
also have dependence-producing properties, and synthetic cannabinoid dependence and synthetic
cannabinoid withdrawal are recognized. Synthetic cannabinoid-induced mental disorders also
occur; in particular, synthetic cannabinoid-induced psychotic disorder is recognized. Much less
is known about the effects of these drugs on other body organs and systems than is the case for
naturally cultivated cannabis.
Disorders due to use of opioids
Disorders due to use of opioids are characterized by the pattern and consequences of opioid use.
“Opioids” is a generic term that encompasses the constituents or derivatives of the opium poppy,
Papaver somniferum, as well as a range of synthetic and semisynthetic compounds – some related
to morphine and others chemically distinct, but all having their primary actions on the µ opioid
receptor. Examples of opioids include morphine, diacetylmorphine (heroin), fentanyl, pethidine,
oxycodone, hydromorphone, methadone, buprenorphine, codeine and d-propoxyphene. The
opioids all have analgesic properties of different potencies, and are primarily central nervous
system depressants. They suppress respiration and other vital functions, and are a common cause
of overdose and related deaths. Certain opioids are used or administered parenterally, including
heroin – a common and potent opioid that is primarily used nonmedically. Therapeutic opioids
are prescribed for a range of indications worldwide, and are essential for pain management in
cancer care and palliative care, although they are also used for nontherapeutic reasons. In some
countries, morbidity and mortality related to therapeutic opioids are greater than those related to
heroin. All opioids may result in opioid intoxication, opioid dependence and opioid withdrawal.
A range of opioid-induced disorders occur, some of which occur following opioid withdrawal.
Because certain opioids are commonly injected illicitly, their use is a potent mechanism of
transmission of bloodborne viral infections such as hepatitis B, hepatitis C and HIV/AIDS, as
well as bacterial infections. Not including alcohol and tobacco, opioids are the most common
cause of death from psychoactive drug use worldwide.
Disorders due to use of sedatives, hypnotics or anxiolytics
Disorders due to use of sedatives, hypnotics or anxiolytics are characterized by the pattern
and consequences of use of these substances. Sedatives, hypnotics and anxiolytics are typically
prescribed for the short-term treatment of anxiety or insomnia, and are also employed to provide
sedation for medical procedures. They include benzodiazepines and the non-benzodiazepine
positive allosteric modulators of GABA receptors (i.e. “Z-drugs”), as well as many other
compounds. Sedatives, hypnotics and anxiolytics include barbiturates, which are available
much less commonly now than in previous decades. Sedatives, hypnotics and anxiolytics have
dependence-inducing properties that are related to the dose and duration of their use. They
may cause intoxication, dependence and withdrawal. Several other mental disorders induced by
sedatives, hypnotics or anxiolytics are recognized.
6C43
6C44
Disorders due to substance use or addictive behaviours | Substance classes

128 - 6C45 Disorders due to use of cocaine
6C45 Disorders due to use of cocaine

129 - 6C46 Disorders due to use of stimulants, incl
6C46 Disorders due to use of stimulants, including amfetamines, methamfetamine and methcathinone

13 - 8A05.00 Tourette syndrome
8A05.00 Tourette syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Tourette syndrome
Essential (required) features
• The presence of both motor tics and phonic tics that may or may not manifest concurrently
or continuously during the symptomatic course is required for diagnosis.
• Motor and phonic tics are defined as sudden, rapid, non-rhythmic and recurrent
movements or vocalizations, respectively.
• Motor and phonic tics have been present for at least 1 year with onset during the
developmental period.
• The symptoms are not a manifestation of another medical condition (e.g. Huntington
disease), and are not due to the effects of a substance or medication on the central nervous
system (e.g. amfetamine), including withdrawal effects (e.g. from benzodiazepines).
Additional clinical features
• Tourette syndrome frequently co-occurs with attention deficit hyperactivity disorder, and
impulsivity, disinhibition, anxiety and immature behaviour may be associated features of
both diagnoses.
• Motor and phonic tics in Tourette syndrome may be voluntarily suppressed for short periods
of time, may be exacerbated by stress, and may diminish during sleep or during periods of
focused enjoyable activity.
• Tics are often highly suggestible – for example, when an individual with Tourette syndrome
is asked about specific symptoms, old tics that have been absent for some time may
transiently reappear.
Boundary with normality (threshold)
• Transient motor or phonic tics (e.g. eye blinking, throat clearing) are common during
childhood, and are differentiated from Tourette syndrome by their transient nature.
8A05.00
Neurodevelopmental disorders | Secondary-parented categories in neurodevelopmental disorders
155
Neurodevelopmental disorders
Course features
• The onset of Tourette syndrome commonly occurs during childhood (between the ages of
4 and 6 years), with peak symptom severity occurring between the ages of 8 and 12 years.
Across adolescence, there is decreasing likelihood of onset. Onset during adulthood is
rare and most often associated with severe psychosocial stressors, use of specific drugs
(e.g. cocaine) or an insult to the central nervous system (e.g. post-viral encephalitis).
• The onset of Tourette syndrome is typically characterized by transient bouts of simple
motor tics such as eye blinking or head jerks. Phonic tics usually begin 1–2 years after
the onset of motor symptoms and initially tend to be simple in character (e.g. throat
clearing, grunting, or squeaking), but then may gradually develop into more complex
vocal symptoms that include repetition of one’s own or another person’s speech or obscene
utterances (i.e. coprolalia). Sometimes the latter is associated with gestural echopraxia,
which also may be of an obscene nature (i.e. copropraxia).
• Vocal and/or motor tics may wax and wane in severity, with some individuals experiencing
remission of symptoms for weeks or months at a time. Eventually the symptoms become
more persistent, and can be accompanied by detrimental effects to personal, family, social,
educational, occupational or other important areas of functioning.
• The majority of individuals with Tourette syndrome will experience significantly
diminished symptoms by early adulthood, with more than one third experiencing a full
remission of symptoms.
• Evidence suggests a good long-term clinical course for individuals with a solitary diagnosis
of Tourette syndrome. Those with co-occurring conditions (e.g. obsessive-compulsive
disorder, attention deficit hyperactivity disorder, anxiety and fear-related disorders,
depressive disorders) tend to exhibit a poorer prognosis.
Developmental presentations
• The prevalence rate of Tourette syndrome among school-aged children has been estimated
at approximately 0.5%.
• Motor and phonic tics in Tourette syndrome tend to be most severe between the ages
of 8 and 12 years, gradually diminishing throughout adolescence. By late childhood
(approximately 10 years of age), most children become aware of premonitory urges (bodily
sensations) and increased discomfort preceding – and relief of tension following – motor
and vocal tics.
• The vocal symptom of coprolalia (inappropriate swearing, experienced involuntarily) is
uncommon, affecting only 10–15% of individuals with Tourette syndrome, and tends to
emerge in mid-adolescence.
• Many adults with childhood-onset Tourette syndrome report attenuated symptoms,
though a small number of adults will continue to experience severe tic symptoms.
Neurodevelopmental disorders | Secondary-parented categories in neurodevelopmental disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The pattern of co-occurring disorders appears to vary with developmental stage. Children
with Tourette syndrome are more likely to experience attention deficit hyperactivity
disorder, obsessive-compulsive disorder, autism spectrum disorder and separation
anxiety disorder compared to adolescents and adults. Adolescents and adults are more
likely than children to develop a depressive disorder, a disorder due to substance use or a
bipolar disorder.
Culture-related features
• Symptoms of Tourette syndrome are consistent across cultural groups.
• If vocalizations or movements have a specific function or meaning in the context of an
individual’s culture and are used in ways that are consistent with that cultural function or
meaning, they should not be considered evidence of Tourette syndrome.
Sex- and/or gender-related features
• Tourette syndrome is more common among males than females (gender ratio ranging
from 2:1 to 4:1).
• Course and symptom presentation do not vary by gender.
• Women with persistent tic disorders may be more likely to experience co-occurring anxiety
and fear-related disorders and depressive disorders.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with autism spectrum disorder and stereotyped movement disorder
Repetitive and stereotyped motor movements such as whole-body movements (e.g. rocking) and
unusual hand or finger movements can be a characteristic feature of autism spectrum disorder and
of stereotyped movement disorder. These behaviours can appear similar to tics, but are differentiated
because they tend to be more stereotyped, last longer than the duration of a typical tic, tend to emerge
at a younger age, are not characterized by premonitory sensory urges, are often experienced by the
individual as soothing or rewarding, and can generally be interrupted with distraction.
Neurodevelopmental disorders | Secondary-parented categories in neurodevelopmental disorders

130 - 6C47 Disorders due to use of synthetic cathin
6C47 Disorders due to use of synthetic cathinones
445
Disorders due to substance use or addictive behaviours
Disorders due to use of cocaine
Disorders due to use of cocaine are characterized by the pattern and consequences of cocaine
use. Cocaine is a compound found in the leaves of the coca plant, Erythroxylum coca, which is
indigenous to countries in northern regions of South America. Cocaine has a limited place in
medical treatment as an anaesthetic and vasoconstrictive agent. It is commonly used illicitly, and
is widely available across the world, where it is found in two main forms: cocaine hydrochloride
and cocaine freebase (also known as “crack”). Cocaine is a central nervous system stimulant, and
cocaine intoxication typically includes a state of euphoria and hyperactivity. Cocaine has potent
dependence-producing properties, and cocaine dependence is a common cause of morbidity and
of clinical presentations. Cocaine withdrawal has a characteristic course that includes lethargy
and depressed mood. A range of cocaine-induced mental disorders is described. Cocaine is also
associated with several health sequelae, including myocardial infarction arising from coronary
artery spasm and stroke arising from cerebral artery spasm.
Disorders due to use of stimulants, including amfetamines,
methamfetamine and methcathinone
Disorders due to use of stimulants, including amfetamines, methamfetamine and methcathinone,
are characterized by the pattern and consequences of use of these substances. There is a wide
array of naturally occurring and synthetically produced psychostimulants other than cocaine. The
most numerous of this group are the amfetamine-type substances, including methamfetamine.
Prescribed stimulants including dexamfetamine are indicated for a limited number of conditions,
such as for attention deficit hyperactivity disorder. Methcathinone, known in many countries as
ephedrone, is a synthetic potent stimulant that is a structural analogue of methamfetamine and
is related to cathinone. All these drugs have primarily psychostimulant properties and are also
vasoconstrictors to a varying degree. They induce euphoria and hyperactivity, as may be seen in
stimulant intoxication. They have potent dependence-producing properties, which may lead to
the diagnosis of stimulant dependence and stimulant withdrawal following the cessation of use.
Several stimulant-induced mental disorders are described. Stimulants are a widespread cause of
hospitalization and clinic attendance, and significant causes of morbidity and mortality, often due
to violence related to stimulant-induced psychotic disorder.
Disorders due to use of synthetic cathinones
Disorders due to use of synthetic cathinones are characterized by the pattern and consequences
of synthetic cathinone use. Synthetic cathinones (also known as “bath salts”) are synthetic
compounds with stimulant properties related to cathinone found in the khat plant, Catha edulis.
The use of synthetic cathinones is common in young populations in many countries. They may
produce a range of disorders including synthetic cathinone intoxication, synthetic cathinone
dependence and synthetic cathinone withdrawal. Several synthetic cathinone-induced mental
disorders are recognized.
6C45
6C47
6C46
Disorders due to substance use or addictive behaviours | Substance classes

131 - 6C48 Disorders due to use of caffeine
6C48 Disorders due to use of caffeine

132 - 6C49 Disorders due to use of hallucinogens
6C49 Disorders due to use of hallucinogens

133 - 6C4A Disorders due to use of nicotine
6C4A Disorders due to use of nicotine
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Disorders due to use of caffeine
Disorders due to use of caffeine are characterized by the pattern and consequences of caffeine use.
Caffeine is a mild psychostimulant and diuretic that is found in the beans of the coffee plant (Coffea
species), and is a constituent of coffee, cola drinks, chocolate, a range of proprietary “energy drinks”
and weight-loss aids. It is the most commonly used psychoactive substance worldwide, and several
clinical conditions related to its use are described, although severe disorders are comparatively
rare considering its ubiquity. Caffeine intoxication related to consumption of relatively high doses
(i.e. >1 g per day) is described. Caffeine withdrawal is common upon cessation of use among
individuals who have used caffeine for a prolonged period or in large amounts. Caffeine-induced
anxiety disorder has been described, often following intoxication or heavy use.
Disorders due to use of hallucinogens
Disorders due to use of hallucinogens are characterized by the pattern and consequences of
hallucinogen use. Several thousand compounds have hallucinogenic properties, many of which
are found in plants (e.g. mescaline) and fungi (e.g. psilocybin) or are chemically synthesized (e.g.
LSD). These compounds have primarily hallucinogenic properties, but some may also be stimulants.
Much of the morbidity associated with these compounds arises from the acute effects related
to hallucinogen intoxication. Hallucinogen dependence is rare, and hallucinogen withdrawal is
not described. Among the mental disorders related to hallucinogen use, hallucinogen-induced
psychotic disorder is the most frequently seen, although worldwide it is still fairly uncommon.
Disorders due to use of nicotine
Disorders due to use of nicotine are characterized by the pattern and consequences of nicotine
use. Nicotine is the active dependence-producing constituent of the tobacco plant, Nicotiana
tabacum. Nicotine is used overwhelmingly through smoking cigarettes. Increasingly, it is also
used in electronic cigarettes that vaporize nicotine dissolved in a carrier solvent for inhalation (i.e.
“vaping”). Pipe smoking, chewing tobacco and inhaling snuff are minor forms of use. Nicotine
is a highly potent addictive compound, and is the third most common psychoactive substance
used worldwide after caffeine and alcohol. Nicotine dependence and nicotine withdrawal are
well described, and nicotine-induced mental disorders are recognized. Tobacco is by far the
most important cause worldwide of morbidity and mortality of all the psychoactive substances;
this is due in part to its addictive constituent nicotine but more so to other constituents such
as carcinogens and other hazardous and harmful compounds that are inhaled during smoking.
Tobacco smoking is the leading cause of ill health and premature death among men, and is among
the top 10 causes in women.
6C48
6C49
6C4A
Disorders due to substance use or addictive behaviours | Substance classes

134 - 6C4B Disorders due to use of volatile inhalan
6C4B Disorders due to use of volatile inhalants

135 - 6C4C Disorders due to use of MDMA or related
6C4C Disorders due to use of MDMA or related drugs, including MDA

136 - 6C4D Disorders due to use of dissociative dru
6C4D Disorders due to use of dissociative drugs, including ketamine and phencyclidine (PCP)
447
Disorders due to substance use or addictive behaviours
Disorders due to use of volatile inhalants
Disorders due to use of volatile inhalants are characterized by the pattern and consequences of
volatile inhalant use. Volatile inhalants include a range of compounds that are in the gaseous or
vapour phase at ambient temperatures, such as various organic solvents, glues, gasoline (petrol),
nitrites and gases such as nitrous oxide, trichloroethane, butane, toluene, fluorocarbons, ether
and halothane. They have a range of pharmacological properties but are predominantly central
nervous system depressants, with many also having vasoactive effects. They tend to be used by
younger people, and may be used when access to alternative psychoactive substances is difficult or
impossible. Volatile inhalant intoxication is well recognized. Volatile inhalants have dependenceproducing properties, and volatile inhalant dependence and volatile inhalant withdrawal
are recognized, although comparatively uncommon worldwide. Volatile inhalant-induced
mental disorders are described. Volatile inhalants may also cause neurocognitive impairment,
including dementia.
Disorders due to use of MDMA or related drugs, including MDA
Disorders due to use of 3,4-Methyl​enedioxy​methamfetamine (MDMA) or related drugs, including
methylenedioxyamfetamine (MDA), are characterized by the pattern and consequences of MDMA
or related drug use. MDMA is a common drug of abuse in many countries especially among
young people. It is predominantly available in tablet form known as “ecstasy”. Pharmacologically,
MDMA has stimulant and empathogenic properties, and these encourage its use among young
people for social and other interactions. Considering its wide prevalence in many countries and
among many subgroups of young people, MDMA and related drug dependence and MDMA and
related drug withdrawal are comparatively uncommon. Substance-induced mental disorders may
arise from its use, and health sequelae are recognized, including liver disease and hyponatraemia,
which may be fatal. Several analogues of MDMA exist, including MDA.
Disorders due to use of dissociative drugs, including ketamine and
phencyclidine (PCP)
Disorders due to use of dissociative drugs, including ketamine and PCP, are characterized by
the pattern and consequences of dissociative drug use. Dissociative drugs include ketamine and
PCP and their (comparatively rare) chemical analogues. Ketamine is an intravenous anaesthetic
widely used in low- and middle-income countries, particularly in Africa, and in emergency
situations. Ketamine is also undergoing evaluation for treatment of some mental disorders (e.g.
treatment-resistant depressive disorders). It is also a widespread drug of nonmedical use in
many countries, and may be taken by the oral or nasal routes or injected. It produces a sense of
euphoria but, depending on the dose, emergent hallucinations and dissociation are recognized
as unpleasant side-effects. Phencyclidine has a more restricted worldwide distribution, and also
has euphoric and dissociative effects. Its use may result in bizarre behaviour uncharacteristic for
the individual, including self-harm. Dissociative drug dependence is described, but a withdrawal
syndrome is not recognized by most authorities. Several dissociative drug-induced mental
disorders are recognized.
6C4B
6C4C
6C4D
Disorders due to substance use or addictive behaviours | Substance classes

137 - 6C4E Disorders due to use of other specified
6C4E Disorders due to use of other specified psychoactive substances, including medications

138 - 6C4F Disorders due to use of multiple specifi
6C4F Disorders due to use of multiple specified psychoactive substances, including medications

139 - 6C4G Disorders due to use of unknown or unspe
6C4G Disorders due to use of unknown or unspecified psychoactive substances

14 - 8A05.01 Chronic motor tic disorder
8A05.01  Chronic motor tic disorder

140 - 6C4H Disorders due to use of non psychoactive
6C4H Disorders due to use of non-psychoactive substances

141 - 6C4Z Disorders due to substance use, unspecif
6C4Z Disorders due to substance use, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Disorders due to use of other specified psychoactive substances,
including medications
Disorders due to use of other specified psychoactive substances, including medications, are
characterized by the pattern and consequences of psychoactive substances that are not included
among the major substance classes specifically identified above. Examples include khat, anabolic
steroids, antidepressants, medications with anticholinergic properties (e.g. benztropine) and
some antihistamines.
Disorders due to use of multiple specified psychoactive substances,
including medications
The categories in this grouping are provided for coding purposes. However, in most clinical
situations it is recommended that multiple categories from disorders due to substance use should
be assigned if these can be discerned, rather than using categories from this grouping. Doing so
will provide more useful information for both clinical and coding purposes.
Disorders due to use of unknown or unspecified psychoactive
substances
These categories apply in clinical situations in which it is clear that the disturbance is due to
substance use but the specific substance or class of substances is initially unknown. As more
information becomes available (e.g. laboratory results, report from a collateral informant) the
diagnosis should be changed to indicate the relevant substance or substance class.
Disorders due to use of non-psychoactive substances
Disorders due to use of non-psychoactive substances are characterized by the pattern and
consequences of nonmedical use of non-psychoactive substances. Non-psychoactive substances
include laxatives, growth hormone, erythropoietin and non-steroidal anti-inflammatory drugs.
They may also include proprietary or over-the-counter medicines and folk remedies. Nonmedical
use of these substances may be associated with harm to the individual due to the direct or
secondary toxic effects of the non-psychoactive substance on body organs and systems, or a
harmful route of administration (e.g. infections due to intravenous self-administration). They
are not associated with intoxication or with a dependence or withdrawal syndrome, and are not
recognized causes of substance-induced mental disorders.
Disorders due to substance use, unspecified
6C4H
6C4E
6C4F
6C4G
Disorders due to substance use or addictive behaviours | Substance classes
6C4Z
449
Disorders due to substance use or addictive behaviours
Diagnostic categories that apply to the various classes
of psychoactive substances
Specific diagnostic categories that apply to the classes of psychoactive substances listed above are
as follows:
• Episode of harmful psychoactive substance use
• Harmful pattern of psychoactive substance use
• Substance dependence
• Substance intoxication
• Substance withdrawal
• Substance-induced delirium
• Substance-induced psychotic disorder
• Substance-induced mood disorder
• Substance-induced anxiety disorder
• Substance-induced obsessive-compulsive or related disorder
• Substance-induced impulse control disorder
• Other specified disorder due to substance use
• Disorder due to substance use, unspecified.
Additional categories of disorders induced by psychoactive substances are included in other parts
of this chapter on mental, behavioural and neurodevelopmental disorders. These categories relate
to substance-induced catatonia, substance-induced amnestic disorder and substance-induced
dementia. They are cross-listed in the section below on substance-induced mental disorders
for reference.
Note that not all possible combinations of disorder and substance class are included in the
classification. For example, there is no category for substance withdrawal due to dissociative
drugs, including ketamine and PCP, and no category for nicotine-induced psychotic disorder.
Allowable categories by substance class for episode of harmful psychoactive substance use,
harmful pattern of psychoactive substance use, substance dependence, substance intoxication
and substance withdrawal are shown in Table 6.13 (p. 450). Allowable categories by substance
class for substance-induced mental disorders (substance-induced delirium, substance-induced
psychotic disorder, substance-induced mood disorder, substance-induced anxiety disorder,
substance-induced obsessive-compulsive or related disorder and substance-induced impulse
control disorder) are shown in Table 6.14 (p. 454).
CDDR are provided below for each type of disorder, together with a list of applicable substance
classes. Information specific to particular substance classes is also provided when applicable.
The first three diagnoses listed above (episode of harmful psychoactive substance use, harmful
pattern of psychoactive substance use and substance dependence) describe the use pattern of the
substance. One of these three diagnoses – or disorder due to substance use, unspecified, for cases
in which the use pattern in unknown at the time of evaluation – is considered to be the primary
diagnosis. That is, one of these four diagnoses should be assigned when making a diagnosis of a
disorder due to substance use.
Diagnostic categories that apply to the various classes of psychoactive substances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
The remaining diagnoses reflect the impact of the substance use pattern, and are thus considered
to be associated with one of the primary use pattern diagnoses. These diagnoses should therefore
be assigned together with the relevant primary diagnosis. For example, 6C49.1/6C49.5 is harmful
pattern of use of hallucinogens associated with hallucinogen-induced psychotic disorder,
6C43.2/6C43.70 is opioid dependence associated with opioid-induced mood disorder, and
6C4Z/6C40.3 is disorder due to substance use, unspecified, associated with alcohol intoxication
(i.e. the pattern of use in this last case is unknown).
Also listed in this section are categories related to hazardous substance use. These categories
are not considered to be mental disorders, but may be used when the pattern of substance use
appreciably increases the risk of harmful physical or mental health consequences, to the user or
to others, to an extent that warrants attention and advice from health professionals, but no overt
harm has yet occurred.
Table 6.13. Applicable disorders due to substance use by substance
class
Episode
of harmful
psychoactive
substance use
Harmful pattern
of psychoactive
substance usea
Substance
dependenceb
Substance
intoxication
Substance
withdrawalc
Alcohol
6C40.0
6C40.10 E
6C40.11 C
6C40.20 C
6C40.21 E
6C40.22 EF
6C40.23 SP
6C40.24 SF
6C40.3
6C40.40 U
6C40.41 PD
6C40.42 S
6C40.43 PD&S
Cannabis
6C41.0
6C41.10 E
6C41.11 C
6C41.20 C
6C41.21 EF
6C41.22 SP
6C41.23 SF
6C41.3
6C41.4
Synthetic
cannabinoids
6C42.0
6C42.10 E
6C42.11 C
6C42.20 C
6C42.21 EF
6C42.22 SP
6C42.23 SF
6C42.3
6C42.4
Opioids
6C43.0
6C43.10 E
6C43.11 C
6C43.20 C
6C43.21 EF
6C43.22 SP
6C43.23 SF
6C43.3
6C43.4
Diagnostic categories that apply to the various classes of psychoactive substances
451
Disorders due to substance use or addictive behaviours
Episode
of harmful
psychoactive
substance use
Harmful pattern
of psychoactive
substance usea
Substance
dependenceb
Substance
intoxication
Substance
withdrawalc
Sedatives, hypnotics
or anxiolytics
6C44.0
6C44.10 E
6C44.11 C
6C44.20 C
6C44.21 EF
6C44.22 SP
6C44.23 SF
6C44.3
6C44.40 U
6C44.41 PD
6C44.42 S
6C44.43 PD&S
Cocaine
6C45.0
6C45.10 E
6C45.11 C
6C45.20 C
6C45.21 EF
6C45.22 SP
6C45.23 SF
6C45.3
6C45.4
Stimulants, including
amfetamines,
methamfetamine and
methcathinone
6C46.0
6C46.10 E
6C46.11 C
6C46.20 C
6C46.21 EF
6C46.22 SP
6C46.23 SF
6C46.3
6C46.4
Synthetic cathinones
6C47.0
6C47.10 E
6C47.11 C
6C47.20 C
6C47.21 EF
6C47.22 SP
6C47.23 SF
6C47.3
6C47.4
Caffeine
6C48.0
6C48.10 E
6C48.11 C
N/A
6C48.2
6C48.3
Hallucinogens
6C49.0
6C49.10 E
6C49.11 C
6C49.20 C
6C49.21 EF
6C49.22 SP
6C49.23 SF
6C49.3
N/A
Table 6.13. contd
Diagnostic categories that apply to the various classes of psychoactive substances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Episode
of harmful
psychoactive
substance use
Harmful pattern
of psychoactive
substance usea
Substance
dependenceb
Substance
intoxication
Substance
withdrawalc
Nicotine
6C4A.0
6C4A.10 E
6C4A.11 C
6C4A.20 C
6C4A.21 EF
6C4A.22 SP
6C4A.23 SF
6C4A.3
6C4A.4
Volatile inhalants
6C4B.0
6C4B.10 E
6C4B.11 C
6C4B.20 C
6C4B.21 EF
6C4B.22 SP
6C4B.23 SF
6C4B.3
6C4B.4
MDMA or related
drugs, including MDA
6C4C.0
6C4C.10 E
6C4C.11 C
6C4C.20 C
6C4C.21 EF
6C4C.22 SP
6C4C.23 SF
6C4C.3
6C4C.4
Dissociative drugs,
including ketamine
and PCP
6C4D.0
6C4D.10 E
6C4D.11 C
6C4D.20 C
6C4D.21 EF
6C4D.22 SP
6C4D.23 SF
6C4D.3
N/A
Other specified
6C4E.0
6C4E.10 E
6C4E.11 C
6C4E.20 C
6C4E.21 EF
6C4E.22 SP
6C4E.23 SF
6C4E.3
6C4E.40 U
6C4E.41 PD
6C4E.42 S
6C4E.43 PD&S
Multiple specified
6C4F.0
6C4F.10 E
6C4F.11 C
6C4F.20 C
6C4F.21 EF
6C4F.22 SP
6C4F.23 SF
6C4F.3
6C4F.40 U
6C4F.41 PD
6C4F.42 S
6C4F.43 PD&S
Table 6.13. contd
Diagnostic categories that apply to the various classes of psychoactive substances
453
Disorders due to substance use or addictive behaviours
Episode
of harmful
psychoactive
substance use
Harmful pattern
of psychoactive
substance usea
Substance
dependenceb
Substance
intoxication
Substance
withdrawalc
Unknown or
unspecified
6C4G.0
6C4G.10 E
6C4G.11 C
6C4G.20 C
6C4G.21 EF
6C4G.22 SP
6C4G.23 SF
6C4G.3
6C4G.40 U
6C4G.41 PD
6C4G.42 S
6C4G.43 PD&S
Non-psychoactive
6C4H.0
6C4H.10 E
6C4H.11 C
N/A
N/A
N/A
a E = episodic; C = continuous
b E = episodic; C = continuous; EF = early full remission; SP = sustained partial remission; SF = sustained full remission
c U = uncomplicated; PD = with perceptual disturbances; S = with seizures; PD&S = with perceptual disturbances and seizures
Table 6.13. contd
Diagnostic categories that apply to the various classes of psychoactive substances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.14. Applicable substance-induced mental disorders by substance class
Delirium
Psychotica
Mood
Anxiety
Obsessivecompulsive
Impulse
control
Amnestic
Dementia
Alcohol
6C40.5
6C40.60 H
6C40.61 D
6C40.62 M
6C40.70
6C40.71
N/A
N/A
6D72.10
6D84.0
Cannabis
6C41.5
6C41.6
6C41.70
6C41.71
N/A
N/A
N/A
N/A
Synthetic cannabinoids
6C42.5
6C42.6
6C42.70
6C42.71
N/A
N/A
N/A
N/A
Opioids
6C43.5
6C43.6
6C43.70
6C43.71
N/A
N/A
N/A
N/A
Sedatives, hypnotics or
anxiolytics
6C44.5
6C44.6
6C44.70
6C44.71
N/A
N/A
6D72.11
6D84.1
Cocaine
6C45.5
6C45.60 H
6C45.61 D
6C45.62 M
6C45.70
6C45.71
6C45.72
6C45.73
N/A
N/A
Stimulants, including
amfetamines,
methamfetamine
and methcathinone
6C46.5
6C46.60 H
6C46.61 D
6C46.62 M
6C46.70
6C46.71
6C46.72
6C46.73
N/A
N/A
Synthetic cathinones
6C47.5
6C47.60 H
6C47.61 D
6C47.62 M
6C47.70
6C47.71
6C47.72
6C47.73
N/A
N/A
Caffeine
N/A
N/A
N/A
6C48.40
N/A
N/A
N/A
N/A
Hallucinogens
6C49.4
6C49.5
6C49.60
6C49.61
N/A
N/A
N/A
N/A
Nicotine
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Volatile inhalants
6C4B.5
6C4B.6
6C4B.70
6C4B.71
N/A
N/A
6D72.13
6D84.2
MDMA or related drugs,
including MDA
6C4C.5
6C4C.6
6C4C.70
6C4C.71
N/A
N/A
N/A
N/A
Dissociative drugs,
including ketamine
and PCP
6C4D.4
6C4D.5
6C4D.60
6C4D.61
N/A
N/A
N/A
N/A
Other specified
6C4E.5
6C4E.6
6C4E.70
6C4E.71
6C4E.72
6C4E.73
6D72.12
6D84.Y
Multiple specified
6C4F.5
6C4F.6
6C4F.70
6C4F.71
6C4F.72
6C4F.73
N/A
N/A
Unknown or unspecified
6C4G.5
6C4G.6
6C4G.70
6C4G.71
6C4G.72
6C4G.73
N/A
N/A
Non-psychoactive
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
a H = with hallucinations, D = with delusions, M = with mixed psychotic symptoms
Diagnostic categories that apply to the various classes of psychoactive substances

142 - Diagnostic requirements for disorders due to
Diagnostic requirements for disorders due to substance use

143 - Episode of harmful psychoactive substance use
Episode of harmful psychoactive substance use
455
Disorders due to substance use or addictive behaviours
Diagnostic requirements for disorders due
to substance use
Episode of harmful psychoactive substance use
Available categories by substance class
6C40.0
Episode of harmful use of alcohol
6C41.0
Episode of harmful use of cannabis
6C42.0
Episode of harmful use of synthetic cannabinoids
6C43.0
Episode of harmful use of opioids
6C44.0
Episode of harmful use of sedatives, hypnotics or anxiolytics
6C45.0
Episode of harmful use of cocaine
6C46.0
Episode of harmful use of stimulants, including amfetamines, methamfetamine
and methcathinone
6C47.0
Episode of harmful use of synthetic cathinones
6C48.0
Episode of harmful use of caffeine
6C49.0
Episode of harmful use of hallucinogens
6C4A.0
Episode of harmful use of nicotine
6C4B.0
Episode of harmful use of volatile inhalants
6C4C.0
Episode of harmful use of MDMA or related drugs, including MDA
6C4D.0
Episode of harmful use of dissociative drugs, including ketamine and PCP
6C4E.0
Episode of harmful use of other specified psychoactive substance
6C4F.0
Episode of harmful use of multiple specified psychoactive substances,
including medications
6C4G.0
Episode of harmful use of unknown or unspecified psychoactive substances
Essential (required) features
• An episode of use of a psychoactive substance that has caused clinically significant
damage to a person’s physical health (e.g. bloodborne infection from intravenous selfadministration) or mental health (e.g. substance-induced mood disorder), or has resulted
in behaviour leading to harm to the health of others, is required for diagnosis.
• Harm to the health of the individual occurs due to one or more of the following: behaviour
related to intoxication (see Table 6.15, p. 475); direct or secondary toxic effects on body
organs and systems; or a harmful route of administration.
• Harm to the health of others includes any form of physical harm, including trauma, or
mental disorder that is directly attributable to behaviour due to substance intoxication on
the part of the person to whom the diagnosis of episode of harmful psychoactive substance
use applies.
Diagnostic requirements for disorders due to substance use | Episode of harmful psychoactive substance use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The harm to health is not better accounted for by another medical condition or another
mental disorder, including another disorder due to substance use (e.g. substance
withdrawal).
Note: harm to the health of the person to whom the diagnosis applies includes injuries caused by
behaviour related to intoxication (e.g. impulsive aggressive behaviour, psychomotor impairment
leading to injury; see Table 6.15, p. 475), acute health problems resulting from substance use
(e.g. overdose, acute gastritis, the effects of hypoxia or prolonged hyperactivity or inactivity), and
exacerbation or decompensation of pre-existing chronic health problems (e.g. hypertension, liver
disease or peptic ulceration). Harm may also result from a harmful route of administration (e.g.
injecting drug use causing bloodborne virus infections, cocaine use causing a perforated nasal
septum). The relevant diagnostic codes from other ICD-11 chapters – including Chapter 22 on
injury, poisoning or certain other consequences of external causes – should be used to describe
the specific health consequences of the harmful substance use.
Harm to the health of others includes any form of physical harm, including trauma (e.g. impaired
driving causing a motor vehicle accident, assaultive behaviour leading to bodily harm to another
person) or mental disorder (e.g. post-traumatic stress disorder arising from an assault by the
intoxicated individual) that is directly attributable to behaviour due to substance intoxication
on the part of the person to whom the diagnosis of episode of harmful psychoactive substance
use applies.
Additional clinical features
• There must be explicit evidence of harm to the individual’s physical or mental health, or
of substance-related behaviour due to intoxication that has led to harm to the physical or
mental health of others. There must also be a clear causal relationship between the harm to
health and the episode of substance use in question.
• The likelihood of harm to self or others due behaviour related to intoxication varies
substantially by substance (see Table 6.15, p. 475). For example, such behaviour is unlikely
to arise from caffeine or nicotine intoxication.
• Psychoactive substance use commonly occurs in the context of other mental disorders.
An additional diagnosis of episode of harmful psychoactive substance use can be made
if the index episode of substance use has resulted in clinically significant harm to the
individual’s physical health, or has exacerbated or triggered an episode of a pre-existing
mental disorder (e.g. a manic or depressive episode or a psychotic episode).
• A diagnosis of episode of harmful psychoactive substance use often signals an opportunity
for intervention – typically a low-intensity intervention that can be implemented in a
wide range of settings, which is specifically aimed at reducing the likelihood of additional
harmful episodes or of progression to harmful pattern of use or substance dependence.
• A diagnosis of episode of harmful psychoactive substance use of unknown or unspecified
psychoactive substances can be assigned if the substance consumed is initially unknown.
As more information becomes available (e.g. laboratory results, report from a collateral
informant) the diagnosis should be changed to indicate the substance responsible for the
episode of harm.
• As more information becomes available indicating that the episode is part of a continuous
or recurrent pattern of substance use, or if additional harmful episodes occur, a diagnosis
of episode of harmful psychoactive substance use should be changed to harmful pattern of
psychoactive substance use or substance dependence, as appropriate.
Diagnostic requirements for disorders due to substance use | Episode of harmful psychoactive substance use
457
Disorders due to substance use or addictive behaviours
Boundary with normality (threshold)
• The diagnosis of episode of harmful psychoactive substance use requires clinically
significant harm to the individual’s physical or mental health or the health of others.
Examples of impact on physical or mental health that would not be considered clinically
significant include mild hangover, brief episodes of vomiting, or transient depressed mood.
• A range of social problems may be associated with an episode of substance use that are not
sufficiently severe to constitute clinically significant harm to physical or mental health (e.g.
missed appointments, arguments with loved ones). Such problems are not a sufficient basis
for a diagnosis of episode of harmful psychoactive substance use.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with hazardous substance use
Hazardous substance use is classified in Chapter 24 on factors influencing health status or contact
with health services and not in this chapter on mental, behavioural and neurodevelopmental
disorders. Hazardous substance use appreciably increases the risk of harmful physical or mental
health consequences, to the user or to others, to an extent that warrants attention and advice from
health professionals, but has not resulted in specific identifiable harm and therefore does not meet
the diagnostic requirements for episode of harmful psychoactive substance use.
Boundary with harmful pattern of psychoactive substance use
If the harm to health is a result of a known episodic or continuous pattern of substance use, and all
other diagnostic requirements are met, a diagnosis of harmful pattern of psychoactive substance
use should be assigned. Substance use is generally considered to be following a pattern if there has
been at least episodic or intermittent use over a period of at least 12 months. If harm is caused by
use of a substance but no information is available about the pattern or history of substance use,
a diagnosis of episode of harmful psychoactive substance use may be assigned until such time as
evidence for a pattern of use is ascertained.
Boundary with substance dependence
In substance dependence, individuals use a substance or substances persistently, despite harm
and adverse consequences. Harm caused by such use may be similar to that observed in episode
of harmful psychoactive substance use. However, substance dependence also includes additional
features of impaired ability to control use and increasing priority given to the substance use over
other activities. Physiological features (e.g. tolerance) may also be present for applicable substances.
If all diagnostic requirements for substance dependence are met for a particular substance, episode
of harmful psychoactive substance use should not be assigned for that substance. Note: substance
dependence is only applicable for some substances or substance classes (see Table 6.13, p. 450).
Diagnostic requirements for disorders due to substance use | Episode of harmful psychoactive substance use

144 - Harmful pattern of psychoactive substance use
Harmful pattern of psychoactive substance use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with substance intoxication
Substance intoxication is defined by substance use that results in clinically significant transient
substance-specific symptoms (see Table 6.15, p. 475). Recovery from substance intoxication is
generally complete and without physical or mental sequelae. If there is continuing damage or harm
(e.g. the effects of hypoxia, the effects of prolonged hyperactivity or inactivity, tissue damage) due
to an episode of substance intoxication, a diagnosis of episode of harmful psychoactive substance
use may be assigned. If relevant at the time of the clinical encounter (e.g. in emergency settings),
episode of harmful psychoactive substance use may be diagnosed with an associated diagnosis of
substance intoxication.
Boundary with substance-induced mental disorders
Substance-induced mental disorders can be associated with a single episode of substance use.
If a substance-induced mental disorder has occurred as a form of harm resulting from a single
episode of substance use, both episode of harmful psychoactive substance use and the relevant
substance-induced mental disorder should be diagnosed (e.g. episode of harmful cocaine use
with cocaine-induced psychotic disorder). Note: specific substance-induced mental disorders are
only applicable for some substances or substance classes (see Table 6.14, p. 454).
Boundary with overdose
When ingestion of psychoactive substances results in symptoms of overdose (e.g. coma, lifethreatening cardiac or respiratory suppression), a diagnosis from the grouping of harmful effects
of substances in Chapter 22 on injury, poisoning or certain other consequences of external causes
should also be assigned.
Harmful pattern of psychoactive substance use
Available categories by substance class
6C40.1
Harmful pattern of use of alcohol
6C41.1
Harmful pattern of use of cannabis
6C42.1
Harmful pattern of use of synthetic cannabinoids
6C43.1
Harmful pattern of use of opioids
6C44.1
Harmful pattern of use of sedatives, hypnotics or anxiolytics
6C45.1
Harmful pattern of use of cocaine
6C46.1
Harmful pattern of use of stimulants, including amfetamines, methamfetamine
and methcathinone
6C47.1
Harmful pattern of use of synthetic cathinones
6C48.1
Harmful pattern of use of caffeine
6C49.1
Harmful pattern of use of hallucinogens
6C4A.1
Harmful pattern of use of nicotine
6C4B.1
Harmful pattern of use of volatile inhalants
6C4C.1
Harmful pattern of use of MDMA or related drugs, including MDA
6C4D.1
Harmful pattern of use of dissociative drugs, including ketamine and PCP
6C4E.1
Harmful pattern of use of other specified psychoactive substance
6C4F.1
Harmful pattern of use of multiple specified psychoactive substances
6C4G.1
Harmful pattern of use of unknown or unspecified psychoactive substances
Diagnostic requirements for disorders due to substance use | Harmful pattern of psychoactive substance use
459
Disorders due to substance use or addictive behaviours
Essential (required) features
• A pattern of continuous, recurrent or sporadic use of a psychoactive substance that has
caused clinically significant damage to a person’s physical health (e.g. bloodborne infection
from intravenous self-administration) or mental health (e.g. substance-induced mood
disorder), or has resulted in behaviour leading to harm to the health of others is required
for diagnosis.
• Harm to the health of the individual occurs due to one or more of the following: behaviour
related to intoxication (see Table 6.15, p. 475); direct or secondary toxic effects on body
organs and systems; or a harmful route of administration.
• Harm to the health of others includes any form of physical harm, including trauma, or
mental disorder that is directly attributable to behaviour related to substance intoxication
on the part of the person to whom the diagnosis of harmful pattern of psychoactive
substance use applies.
• The pattern of use of the relevant substance is evident over a period of at least 12 months if
substance use is episodic, or at least 1 month if use is continuous.
• The harm to health is not better accounted for by another medical condition or another
mental disorder, including another disorder due to substance use (e.g. substance
withdrawal).
Note: harm to the health of the person to whom the diagnosis applies includes injuries caused by
behaviour related to intoxication (e.g. impulsive aggressive behaviour, psychomotor impairment
leading to injury; see Table 6.15, p. 475); acute health problems resulting from substance use
(e.g. overdose, acute gastritis, the effects of hypoxia or prolonged hyperactivity or inactivity), and
exacerbation or decompensation of pre-existing chronic health problems (e.g. hypertension, liver
disease, or peptic ulceration). Harm may also result from a harmful route of administration (e.g.
injecting drug use causing bloodborne virus infections, cocaine use causing a perforated nasal
septum). The relevant diagnostic codes from other ICD-11 chapters – including Chapter 22 on
injury, poisoning or certain other consequences of external causes – should be used to describe
the specific health consequences of the harmful substance use.
Harm to the health of others includes any form of physical harm, including trauma (e.g. impaired
driving causing a motor vehicle accident, assaultive behaviour leading to bodily harm to another
person) or mental disorder (e.g. post-traumatic stress disorder arising from an assault by the
intoxicated individual) that is directly attributable to behaviour due to substance intoxication
on the part of the person to whom the diagnosis of harmful pattern of psychoactive substance
use applies.
Diagnostic requirements for disorders due to substance use | Harmful pattern of psychoactive substance use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Course specifiers
A specifier is used to further describe the harmful pattern of substance use, using a fifth-character
code. The x below corresponds to the fourth-character code indicating the substance class (0 for
alcohol, 1 for cannabis, 2 for synthetic cannabinoids and so on).
Harmful pattern of psychoactive substance use, episodic
This category is assigned when all the diagnostic requirements for harmful pattern of psychoactive
substance use are met, and there is evidence of a pattern of recurrent episodic or intermittent
use of the relevant psychoactive substance over a period of at least 12 months that has caused
clinically significant harm to a person’s physical or mental health or has resulted in behaviour
leading to harm to the health of others.
Harmful pattern of psychoactive substance use, continuous
This category is assigned when all the diagnostic requirements for harmful pattern of psychoactive
substance use are met, and there is evidence of a pattern of continuous substance use (daily
or almost daily) of the relevant psychoactive substance over a period of at least 1 month that
has caused clinically significant harm to a person’s physical or mental health or has resulted in
behaviour leading to harm to the health of others.
Harmful pattern of psychoactive substance use, unspecified
Additional clinical features
• There must be explicit evidence of harm to the individual’s physical or mental health, or
of behaviour due to substance intoxication that has led to harm to the physical or mental
health of others. There must also be a clear causal relationship between the harm to health
and the episodic or continuous use of a substance.
• The likelihood of harm to self or others due behaviour related to intoxication varies
substantially by substance (see Table 6.15, p. 475). For example, such behaviour is unlikely
to arise from caffeine or nicotine intoxication.
• A diagnosis of harmful pattern of use of unknown or unspecified psychoactive substances
can be assigned if the substance consumed is initially unknown. As more information
becomes available (e.g. laboratory results, report from a collateral informant) the diagnosis
should be changed to indicate the substance(s) involved in the harmful pattern of
psychoactive substance use.
• As more information becomes available about symptoms and behaviours related to the
pattern of substance use, as well as physiological features indicative of neuroadaptation
6C4x.10
6C4x.11
6C4x.1Z
Diagnostic requirements for disorders due to substance use | Harmful pattern of psychoactive substance use
461
Disorders due to substance use or addictive behaviours
to the substance, the diagnosis may be changed to substance dependence if diagnostic
requirements are met.
Boundary with normality (threshold)
• The diagnosis of harmful pattern of psychoactive substance use requires clinically significant
harm to the individual’s physical or mental health or the health of others. Examples of
impact on physical or mental health that would not be considered clinically significant
include mild hangovers, brief episodes of vomiting, or transient depressed mood.
• A pattern of psychoactive substance use may cause a range of problems in functioning
(e.g. missed appointments, arguments with loved ones) that are not sufficiently severe to
constitute clinically significant harm to physical or mental health. Such problems are not a
sufficient basis for a diagnosis of harmful pattern of psychoactive substance use.
Developmental presentations
• Harmful pattern of psychoactive substance use is often a characteristic of late adolescence
and young adulthood, and injuries and the consequences of aggressive behaviour are
particularly common in this age group.
• Harmful pattern of psychoactive substance use in older adults may cause injuries and
fractures due to the combination of lowered tolerance, psychomotor impairment induced
by a substance, and disorders associated with ageing such as osteoporosis and dementia.
Sex- and/or gender-related features
• The prevalence of harmful pattern of psychoactive substance use is higher in males, but
the gender differential is smaller in countries where women play a greater role in the
workforce. Gender differences in injuries and other forms of harm due to substance use
are recognized.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with hazardous substance use
Hazardous substance use is classified in Chapter 24 on factors influencing health status or contact
with health services and not in this chapter on mental, behavioural and neurodevelopmental
disorders. hazardous substance use appreciably increases the risk of harmful physical or mental
health consequences, to the user or to others, to an extent that warrants attention and advice from
Diagnostic requirements for disorders due to substance use | Harmful pattern of psychoactive substance use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
health professionals, but has not resulted in specific identifiable harm and therefore does not meet
the diagnostic requirements for harmful pattern of psychoactive substance use.
Boundary with episode of harmful psychoactive substance use
If the harm to health is a result of a single episode of use rather than a pattern of substance use,
whether episodic or continuous, a diagnosis of episode of harmful psychoactive substance use
should be assigned. Substance use is generally considered to be following a pattern if there has
been at least episodic or intermittent use over a period of at least 12 months. If harm is caused by
use of a substance but no information is available about the pattern or history of substance use,
a diagnosis of episode of harmful psychoactive substance use may be assigned until such time as
evidence for a pattern of use is ascertained.
Boundary with substance dependence
In substance dependence, individuals use a substance or substances persistently, despite harm and
adverse consequences. Harm caused by such use may be similar to that observed in harmful pattern
of psychoactive substance use. However, substance dependence also includes additional features
of impaired ability to control use and increasing priority given to the substance use over other
activities. Physiological features (e.g. tolerance) may also be present for applicable substances. If
all diagnostic requirements for substance dependence are met for a particular substance, Harmful
pattern of psychoactive substance use should not be assigned for that substance. Note: substance
dependence is only applicable for some substances or substance classes (see Table 6.13, p. 450).
Boundary with substance intoxication
Substance intoxication is defined by substance use that results in clinically significantly, transient
substance-specific symptoms (see Table 6.15, p. 475). Recovery from substance intoxication is
generally complete and absent of physical or mental sequelae. A pattern or repeated intoxication
may or may not result in harm to a person’s physical or mental health or to the health of others. If
there is continuing damage or harm (e.g. the effects of hypoxia, the effects of prolonged hyperactivity
or inactivity, tissue damage) as a result of repeated or continuous use of a psychoactive substance,
a diagnosis of harmful pattern of psychoactive substance use may be assigned. If relevant at
the time of the clinical encounter (e.g. in emergency settings), harmful pattern of psychoactive
substance use may be diagnosed with an associated diagnosis of substance intoxication.
Boundary with substance withdrawal
Substance withdrawal occurs upon cessation or reduction of a substance in the context of
physiological dependence, or when a substance has been taken for a prolonged period or in
large amounts. Some features of substance withdrawal may include physical or mental harm
(e.g. seizures, delusions, hallucinations, anxiety). If the symptoms are entirely explained by the
withdrawal syndrome for the relevant substance (see Table 6.16, p. 484), an additional diagnosis
of harmful pattern of psychoactive substance use is not warranted. However, if the symptoms
substantially exceed the expected withdrawal syndrome in duration or type or severity, and the
diagnostic requirements for substance dependence are not met, harmful pattern of psychoactive
substance use can be assigned as the primary diagnosis, with an associated diagnosis of substance
withdrawal (e.g. harmful pattern of use of opioids with opioid withdrawal). Note: substance
withdrawal is only applicable for some substances or substance classes (see Table 6.13, p. 450).
Boundary with substance-induced mental disorders
If a substance-induced mental disorder has occurred as a form of harm resulting from a pattern
of substance use, both harmful pattern of psychoactive substance use and the relevant substanceinduced mental disorder should be diagnosed (e.g. harmful pattern of cocaine use with cocaineinduced anxiety disorder). Note: specific substance-induced mental disorders are only applicable
for some substances or substance classes (see Table 6.14, p. 454).
Diagnostic requirements for disorders due to substance use | Harmful pattern of psychoactive substance use

145 - Substance dependence
Substance dependence
463
Disorders due to substance use or addictive behaviours
Boundary with other mental disorders and other medical conditions
Numerous mental disorders and subthreshold symptoms may co-occur with episodic or
continuous patterns of substance use. Similarly, continuous or episodic substance use increases
the risk of mental disorders and other medical conditions. Co-occurring mental disorders and
comorbid medical conditions should be diagnosed separately, along with a diagnosis of harmful
pattern of psychoactive substance use.
Substance dependence
Available categories by substance class
6C40.2
Alcohol dependence
6C41.2
Cannabis dependence
6C42.2
Synthetic cannabinoid dependence
6C43.2
Opioid dependence
6C44.2
Sedative, hypnotic or anxiolytic dependence
6C45.2
Cocaine dependence
6C46.2
Stimulant dependence, including amfetamines, methamfetamine and
methcathinone
6C47.2
Synthetic cathinone dependence
6C49.2
Hallucinogen dependence
6C4A.2
Nicotine dependence
6C4B.2
Volatile inhalant dependence
6C4C.2
MDMA or related drug dependence, including MDA
6C4D.2
Dissociative drug dependence, including ketamine and PCP
6C4E.2
Other specified psychoactive substance dependence
6C4F.2
Multiple specified psychoactive substance dependence
6C4G.2
Unknown or unspecified psychoactive substance dependence
Essential (required) features
• A pattern of recurrent episodic or continuous use of a psychoactive substance is required for
diagnosis, with evidence of impaired regulation of use of that substance that is manifested
in two or more of the following:
• impaired control over substance use (i.e. onset, frequency, intensity, duration, termination,
context);
• increasing precedence of substance use over other aspects of life, including maintenance
of health, and daily activities and responsibilities, such that substance use continues
or escalates despite the occurrence of harm or negative consequences (e.g. repeated
relationship disruption, occupational or scholastic consequences, negative impact on
health);
• physiological features indicative of neuroadaptation to the substance, including
tolerance to the effects of the substance or a need to use increasing amounts
of the substance to achieve the same effect; withdrawal symptoms following
cessation or reduction in use of that substance; or repeated use of the substance or
Diagnostic requirements for disorders due to substance use | Substance dependence
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
pharmacologically similar substances to prevent or alleviate withdrawal symptoms
(substance-specific features of withdrawal are described in Table 6.16, p. 484).
Note: physiological features are only applicable for certain substances.
• The features of dependence are usually evident over a period of at least 12 months, but the
diagnosis may be made if use is continuous (daily or almost daily) for at least 3 months.
Course specifiers for alcohol dependence
For alcohol, a specifier is used to describe the pattern of substance use or remission. Unlike for
other substances, a distinction is made between continuous and episodic use, as follows.
Alcohol dependence, current use, continuous
The individual exhibits alcohol dependence, with continuous consumption of alcohol (daily or
almost daily) during at least the past month.
Alcohol dependence, current use, episodic
The individual exhibits alcohol dependence, with use during the past month and a history of
intermittent heavy drinking, with periods of abstinence during the past 12 months.
Alcohol dependence, early full remission
After a diagnosis of alcohol dependence, and often following a treatment episode or other
intervention (including self-help intervention), the individual has been abstinent from alcohol
during a period lasting between 1 and 12 months.
Alcohol dependence, sustained partial remission
After a diagnosis of alcohol dependence, and often following a treatment episode or other
intervention (including self-help intervention), there is a significant reduction in alcohol
consumption for more than 12 months, such that even though intermittent or continuing
drinking has occurred during this period, the definitional requirements for dependence have not
been met.
Alcohol dependence, sustained full remission
After a diagnosis of alcohol dependence, and often following a treatment episode or other
intervention (including self-intervention), the person has been abstinent from alcohol for 12
months or longer.
6C40.20
6C40.21
6C40.22
6C40.23
Diagnostic requirements for disorders due to substance use | Substance dependence
6C40.24
465
Disorders due to substance use or addictive behaviours
Alcohol dependence, unspecified
Course specifiers for substance dependence for substances other
than alcohol
For all psychoactive substance classes other than alcohol (see the list above and Table 6.13, p. 450),
a specifier is used to further describe the pattern of substance use or remission in the context of
substance dependence, using a fifth-character code. Unlike alcohol, separate codes for continuous
and episodic current use are not provided. The x below corresponds to the fourth-character code
indicating the substance class (1 for cannabis, 2 for synthetic cannabinoids and so on).
Substance dependence, current use
The individual exhibits current substance dependence, with episodic or continuous use of the
substance within the past month.
Substance dependence, early full remission
After a diagnosis of substance dependence, and often following a treatment episode or other
intervention (including self-help intervention), the individual has been abstinent from the
substance during a period lasting between 1 and 12 months.
Substance dependence, sustained partial remission
After a diagnosis of substance dependence, and often following a treatment episode or other
intervention (including self-help intervention), there is a significant reduction in substance use
for more than 12 months, such that even though intermittent or continuous use has occurred
during this period, the diagnostic requirements for dependence have not been met.
Substance dependence, sustained full remission
After a diagnosis of substance dependence, and often following a treatment episode or other
intervention (including self-intervention), the person has been abstinent from the substance for
12 months or longer.
Substance dependence, unspecified
6C40.2Z
6C4x.20
6C4x.21
6C4x.22
6C4x.23
6C4x.2Z
Diagnostic requirements for disorders due to substance use | Substance dependence
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features for substance dependence
• A subjective sensation of urge or craving to use the substance often, but not always,
accompanies the essential features of substance dependence.
• When present as an aspect of substance dependence, withdrawal symptoms must be
consistent with the known withdrawal state for that substance (see Table 6.16, p. 484).
Onset and course of withdrawal are time-limited, and are related to the type of substance
and the dose used immediately before cessation or reduction in amount.
• Tolerance varies as a function of individual factors (e.g. substance use history, genetics)
and should be differentiated from initial levels of response during intoxication, which also
exhibit significant individual variability. Laboratory testing that reveals high levels of the
substance in bodily fluids with no evidence of significant symptoms of intoxication may
be suggestive of tolerance. Tolerance to the effects of substances as indicated by different
psychophysiological responses can develop at varying rates (e.g. tolerance to respiratory
depression caused by opioid intoxication may develop prior to tolerance to the sedating
effects of the drug). With abstinence, tolerance effects diminish over time.
• Individuals with certain comorbid medical conditions (e.g. chronic liver disease) typically
have reduced tolerance to substances.
• Physical or mental health consequences (beyond the essential features of substance
dependence) typically occur in people with substance dependence, but are not required
for the diagnosis. Similarly, functional impairment in one or several domains of life (e.g.
work, domestic responsibilities, child-rearing) is commonly seen in people with substance
dependence, but is not required in order to assign the diagnosis.
• Individuals with substance dependence have elevated rates of many other mental disorders,
including conduct-dissocial disorder, attention deficit hyperactivity disorder, impulse
control disorders, post-traumatic stress disorder, social anxiety disorder, generalized
anxiety disorder, mood disorders, psychotic disorders and personality disorder with
prominent dissocial features, as well as subthreshold symptoms. The specific pattern
of co-occurrence depends on the substance involved, and reflects common risk factors
and common causal pathways. These are distinguished from substance-induced mental
disorders, in which the symptoms are a result of the direct physiological effects of the
substance on the central nervous system.
• A pattern of substance use that includes frequent or high dose administration occurs more
often among certain subgroups (e.g. adolescents). In these cases, peer-group dynamics
may contribute to the maintenance of substance use. Regardless of the social contributions
to the behaviour, a pattern of substance use that is consistent with subgroup norms should
not be considered as presumptive evidence of substance dependence unless all diagnostic
requirements for the disorder are met.
Diagnostic requirements for disorders due to substance use | Substance dependence
467
Disorders due to substance use or addictive behaviours
Boundary with normality (threshold)
• Frequent or even daily substance use of a substance does not automatically imply a
diagnosis of substance dependence. There must also be evidence of the essential features
of substance dependence, such as impaired control over use, increasing precedence of use
over other life priorities or physiological features.
• The presence of physiological features such as tolerance and withdrawal is sometimes
referred to as “physiological dependence”. These features may occur, for example, in
response to prolonged therapeutic use of certain medications, such as in patients who are
appropriately prescribed opioid analgesics for cancer pain. By themselves, however, these
features are not sufficient for a diagnosis of substance dependence, which also requires
either impaired control over substance use or increasing precedence of substance use over
other activities.
Course features
• The course of substance dependence varies by substance, frequency, intensity and duration
of use. The central features of the dependence syndrome may be overshadowed by the
harms to physical and mental health that patients with dependence often experience, and
for which they frequently seek treatment. Numerous medical conditions can occur due to
substance use in the course of substance dependence. These conditions tend to be specific
for each substance, although some are shared across substances. Negative consequences
to physical health reflect the known pharmacological effects of the relevant substance,
the toxic effects of the substance on tissues and organs, or the route of administration
(e.g. intravenous self-administration). Examples include alcoholic cirrhosis, infective
endocarditis and HIV/AIDS. Medical conditions caused by substance use should be
diagnosed separately.
Developmental presentations
• Substance dependence may develop more rapidly during adolescence than is usual
during adulthood, especially when there are familial or other risk factors for substance
dependence.
• Tolerance to psychoactive substances may develop rapidly in adolescents and young
adults, and may decline equally rapidly when substance use ceases or is reduced in quantity
or frequency.
• Withdrawal symptoms are well recognized in neonates born to women with substance
dependence who have used psychoactive substances during pregnancy. However, the
presence of a withdrawal state in a neonate should not be the sole basis for a diagnosis of
substance dependence in the mother.
• Older adults often have reduced tolerance to substances.
Diagnostic requirements for disorders due to substance use | Substance dependence
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Substance dependence has similar features in men and women, although the intensity of
substance use and duration of use necessary to result in dependence may differ by sex. For
example, alcohol dependence may occur after a lower cumulative alcohol intake in women
compared to men because of sex-related differences in body mass and composition.
• Women are less likely to be involved with the legal system in relation to substance use, and
therefore may be less likely to come to clinical attention than men. In clinical contexts,
women may be reluctant to admit using substances due to prevailing social attitudes and
proscriptions.
• In some societies it may be culturally unacceptable for women to admit to substance use.
Specific probing may be necessary to elicit a history of substance use and dependence.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with substance intoxication
Episodic or continuous intoxication with substances is a typical feature of substance dependence,
but is not an essential feature. Conversely, even if frequent and severe, substance intoxication
alone is not a basis for a diagnosis of substance dependence. If all diagnostic requirements of
both conditions are met for the same episode of care, substance dependence should be assigned
as the primary diagnosis, with an associated diagnosis of substance intoxication (e.g. opioid
dependence with opioid intoxication) if appropriate to the specific clinical situation (e.g. in
emergency settings).
Boundary with harmful substance use
Substance dependence is often associated with physical and mental health consequences, such
as those seen in harmful pattern of psychoactive substance use. In the absence of the essential
features of substance dependence, a diagnosis of harmful substance use can be given when
there has been demonstrable harm to the individual’s physical or mental health or the health of
others. Harmful pattern of psychoactive substance use and substance dependence should not be
diagnosed together.
Boundary with substance withdrawal
Depending on the substance, many individuals with substance dependence develop substance
withdrawal upon cessation or reduction in the amount of a substance consumed. In such cases,
both substance dependence and substance withdrawal should be diagnosed. However, substance
withdrawal can be diagnosed in the absence of a diagnosis of substance dependence – for
example, in response to cessation of medically appropriate treatment with opioid analgesics that
is not accompanied by the other essential features of substance dependence. Note: substance
withdrawal is only applicable for some substances or substance classes (see Table 6.13, p. 450).
Boundary with substance-induced mental disorders
The impact of repeated or continuous use of substances characteristic of substance dependence
may include substance-induced mental disorders, in which case both substance dependence and
the relevant substance-induced mental disorder should be diagnosed (e.g. alcohol dependence
with alcohol-induced delirium). Note: specific substance-induced mental disorders are only
applicable for some substance classes (see Table 6.14, p. 454).
Diagnostic requirements for disorders due to substance use | Substance dependence

146 - Substance intoxication
Substance intoxication
469
Disorders due to substance use or addictive behaviours
Substance intoxication
Available categories by substance class
6C40.3
Alcohol intoxication
6C41.3
Cannabis intoxication
6C42.3
Synthetic cannabinoid intoxication
6C43.3
Opioid intoxication
6C44.3
Sedative, hypnotic or anxiolytic intoxication
6C45.3
Cocaine intoxication
6C46.3
Stimulant intoxication, including amfetamines, methamfetamine
and methcathinone
6C47.3
Synthetic cathinone intoxication
6C48.2
Caffeine intoxication
6C49.3
Hallucinogen intoxication
6C4A.3
Nicotine intoxication
6C4B.3
Volatile inhalant intoxication
6C4C.3
MDMA or related drug intoxication, including MDA
6C4D.3
Dissociative drug intoxication, including ketamine and PCP
6C4E.3
Other specified psychoactive substance intoxication
6C4F.3
Intoxication due to multiple specified psychoactive substances
6C4G.3
Intoxication due to unknown or unspecified psychoactive substances
Essential (required) features
• The presentation is characterized by transient and clinically significant disturbances in
consciousness, cognition, perception, affect, behaviour or coordination that develop
during or shortly after the consumption or administration of a substance.
• The symptoms are compatible with the known pharmacological effects of the substance,
and their intensity is closely related to the amount of the substance consumed.
• The symptoms of intoxication are time-limited, and abate as the substance is cleared from
the body.
• Symptoms are not better accounted for by another medical condition (see Box 6.1) or
another mental disorder, including another disorder due to substance use (e.g. substance
withdrawal).
Note: Table 6.15 (p. 475) lists clinically important presenting features of substance intoxication
attributable to the pharmacological effects of each substance class.
Diagnostic requirements for disorders due to substance use | Substance intoxication
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Severity of intoxication specifier
Depending on the specific clinical situation and the information available, substance
intoxication may be classified according to the level of severity as mild, moderate or severe.
The level of intoxication is usually related to the dose, route of administration, half-life and
duration of action of the substance. Severity of intoxication is also affected by individual
variability (e.g. differences in body weight, substance metabolism, tolerance). Susceptibility to
substance intoxication may also be greater in individuals with comorbid medical conditions
affecting drug pharmacokinetics (e.g. renal or hepatic insufficiency).
For some substances, there are specific tests for detecting and determining the concentration
of substances in bodily fluids (e.g. blood, urine), which can be important tools for clinical
management. However, severity of intoxication should be determined on the basis of clinical
assessment, as specified below, and not solely based on the presence and level of the substance
in bodily fluids.
The level of medical attention that may be required in response to substance intoxication
varies according to the severity of intoxication and the substance involved, and varies from
precautionary observation to urgent intervention to prevent death or permanent harm (e.g.
administration of antagonist treatment, intubation).
Severity of intoxication can be rated as mild (XS5W), moderate (XS0T) or severe (XS25),
using extension codes, in addition to the appropriate substance intoxication category.
To indicate severity, the code for the appropriate severity level is appended to the substance
intoxication diagnostic code using an ampersand (&). For example, “6C43.3&XS25” is the
code for opioid intoxication, severe.
Box 6.1. Examples of medical conditions that may present
with symptoms similar to substance intoxication
• Head injury (with or without cerebral contusion or intracranial
haemorrhage or haematoma)
• Meningitis and encephalitis
• Diabetic ketoacidosis or hypoglycaemia
• Hepatic or other metabolic encephalopathy
• Wernicke’s encephalopathy
• Electrolyte disturbance
• Hypoxia or hypercapnia
• Systemic infection
Diagnostic requirements for disorders due to substance use | Substance intoxication
471
Disorders due to substance use or addictive behaviours
Mild substance intoxication
Mild substance intoxication is a state in which there are clinically recognizable disturbances in
psychophysiological functions and responses (e.g. motor coordination, attention and judgement)
that vary by substance (see Table 6.15, p. 475), but there is little or no disturbance in the level
of consciousness.
Moderate substance intoxication
Moderate substance intoxication is a state in which there are marked disturbances in
psychophysiological functions and responses (e.g. motor coordination, attention and judgement)
that vary by substance (see Table 6.15, p. 475), with substantial impairment on tasks that require
these functions. There is some disturbance in level of consciousness.
Severe substance intoxication
Severe substance intoxication is a state in which there are obvious disturbances in
psychophysiological functions and responses (e.g. motor coordination, attention and judgement)
that vary by substance (see Table 6.15, p. 475), with marked disturbance in level of consciousness.
There is severe impairment to the extent that the person may not be capable of self-care or selfprotection, and may be unable to communicate or cooperate with assessment and intervention.
Note: extension codes are attached to the category to which they apply using an ampersand (&).
For example, 6C40.3&XS0T is the code for alcohol intoxication, moderate and 6C41.3&XS5W is
the code for cannabis intoxication, mild.
Additional clinical features for substance intoxication
• Psychoactive substances, whether of the same or a different pharmacological class, may
interact such that they exacerbate or modify the features of intoxication. In cases of multiple
psychoactive substance use in which more than one specific substance can be identified as
a cause of the intoxication, it is recommended that the corresponding specific substance
intoxication categories for each relevant substance should be assigned (e.g. 6C40.3 Alcohol
intoxication and 6C41.3 Cannabis intoxication) rather than 6C4F.3 Intoxication due to
multiple specified psychoactive substances.
• Substance intoxication may occur in the presence of medical conditions that cause
impairment of levels of consciousness, cognition, perception, affect, behaviour or
coordination, which should be diagnosed separately. Determination of the etiology of
the disturbances in psychophysiological functions or responses may require longitudinal
assessment.
• A diagnosis of intoxication due to unknown or unspecified psychoactive substances can
be assigned if the substance consumed is initially unknown to the clinician. As more
information becomes available (e.g. laboratory results, report from a collateral informant)
the diagnosis should be changed to indicate the substance responsible for intoxication.
XS5W
XS0T
XS25
Diagnostic requirements for disorders due to substance use | Substance intoxication
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• Measurement of the presence or concentration of a substance in breath, blood, saliva, urine
or other body fluids may be an important tool in the clinical management of substance
intoxication. However, detection of a psychoactive substance in body fluids does not
constitute a presumptive diagnosis of substance intoxication.
Course features
• The onset of substance intoxication varies according to the route of administration, the
absorption of the substance and other pharmacokinetic factors. Generally, inhalation
(smoking) and intravenous injecting routes lead to more rapid onset of intoxication,
although oral ingestion may also lead to intoxication within minutes, depending on the
substance.
• Substance intoxication is a transient condition, with the duration of intoxication
depending on multiple factors, including the dose of the substance taken, the half-life and
duration of action of the particular substance, and the formulation of the substance taken
(e.g. for pharmaceutical preparations, whether a controlled-release drug has been taken).
Intoxication may last from a few minutes to several days following the episode of use. The
intensity of intoxication lessens with time after reaching a peak of absorption, and the
effects eventually disappear in the absence of further use of the substance.
Developmental presentations
• Naive users – including adolescents – can show features of intoxication at lower levels of
use, reflecting lower physical and learned tolerance.
• Older adults may have a lower tolerance than younger people to the effects of alcohol and
other substances.
Culture-related features
• The degree and characteristics of intoxication displayed for a given amount of the substance
vary considerably with circumstances, with beliefs and expectations about the effects of
the substance, and with the cultural acceptability of displaying these effects. These factors
result in cultural differences in the extent and manifestations of intoxication.
Diagnostic requirements for disorders due to substance use | Substance intoxication
473
Disorders due to substance use or addictive behaviours
• There are also genetic differences in susceptibility to intoxication associated with certain
ethnic groups. Cultural and ethnically linked genetic factors have been better documented
for alcohol than for other substances.
Sex- and/or gender-related features
• The amount of substance and duration of use necessary to cause intoxication differs by sex,
reflecting differences in body weight and composition.
• Behaviour while intoxicated may vary by gender, reflecting not only physiological
differences but also cultural differences and role expectations.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with episode of harmful psychoactive substance use and harmful pattern
of psychoactive substance use
In episode of harmful psychoactive substance use and harmful pattern of psychoactive substance
use, consumption or administration of a substance results in damage to the person’s physical or
mental health (including a substance-induced mental disorder) or in behaviour leading to harm to
the health of others. Recovery from substance intoxication is generally complete. Complications
due to such effects of intoxication such as injury, the effects of hypoxia, the effects of prolonged
hyperactivity or inactivity, or other tissue damage should be diagnosed as episode of harmful
psychoactive substance use or harmful pattern of psychoactive substance use, as appropriate. If
relevant at the time of the clinical encounter (e.g. in emergency settings), substance intoxication
can be given as an associated diagnosis, with episode of harmful psychoactive substance use or
harmful pattern of psychoactive substance use as the primary diagnosis.
Boundary with substance dependence
Episodic or continuous intoxication with a substance or substances is a typical feature of substance
dependence. If all diagnostic requirements of both conditions are met for the same episode of care,
substance dependence should be assigned as the primary diagnosis, with an associated diagnosis
of substance intoxication (e.g. opioid dependence with opioid intoxication).
Boundary with substance withdrawal
Substance withdrawal occurs upon cessation or reduction of a substance in the context of
physiological dependence or when a substance has been taken for a prolonged period or in
large amounts. In contrast, the onset of substance intoxication occurs immediately or shortly
after the consumption of a substance. Moreover, for a particular substance, the intoxication and
withdrawal syndromes are typically quite distinct. See Table 6.15 (p. 475) for a description of the
substance-specific features of substance intoxication and Table 6.16 (p. 484) for a description of
the substance-specific features of substance withdrawal.
Diagnostic requirements for disorders due to substance use | Substance intoxication
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with substance-induced delirium
Delirium is characterized by disturbances in attention, orientation and awareness that develop
within a short period of time, with symptoms that are transient and may fluctuate depending
on the underlying etiology. Delirium often includes disturbance of behaviour and emotion, and
may include impairment in multiple cognitive domains. Disturbance of the sleep-wake cycle
may also be present. Delirium can be caused by intoxication or withdrawal from substances.
When symptoms of delirium are attributable to substance intoxication, an associated diagnosis
of substance-induced delirium should be assigned in addition to the diagnosis of substance
intoxication. Note: substance-induced delirium is only applicable for some substances or
substance classes (see Table 6.14, p. 454).
Boundary with other substance-induced mental disorders
Mental or behavioural symptoms that arise during substance intoxication should only be used
as a basis for diagnosing a substance-induced mental disorder if the intensity or duration of the
symptoms is substantially in excess of those that are characteristic of substance intoxication due
to the specified substance (see Table 6.15, p. 475), and the symptoms are sufficiently severe to
warrant specific clinical attention.
Boundary with other medical conditions
A variety of medical conditions may produce symptoms that are similar to those of substance
intoxication (see Box 6.1 for examples). Some of these medical conditions are life-threatening,
and require immediate intervention. Evidence of substance use (e.g. positive laboratory results)
does not rule out the possibility of a comorbid medical condition. These alternative diagnoses
must be considered in assessing substance intoxication. Certain medical conditions may also
augment or prolong the duration of intoxication. Symptoms of intoxication that persist after
they can no longer be reasonably attributed to the pharmacological effects of the substance may
suggest the presence of another medical condition. If it is determined that substance intoxication
is comorbid with a medical condition, both diagnoses should be assigned.
Boundary with overdose
When consumption or administration of psychoactive substances results in symptoms of overdose
(e.g. coma, life-threatening cardiac or respiratory suppression), it is typically more appropriate to
apply a diagnosis from the grouping of harmful effects of substances in Chapter 22 on injury,
poisoning or certain other consequences of external causes rather than substance intoxication.
Table 6.15 sets out the disturbances in consciousness, cognition, perception, affect, behaviour
or coordination that are most characteristic of intoxication with each class of psychoactive
substances in the grouping of disorders due to substance use. These features are caused by the
known pharmacological effects of the substance. Their intensity is closely related to the amount of
the substance consumed, as well as the route of administration, interaction of the substance with
other substances – including medications – and the duration of action of the substance. They are
time-limited, and abate as the substance is cleared from the body.
Diagnostic requirements for disorders due to substance use | Substance intoxication
475
Disorders due to substance use or addictive behaviours
Table 6.15. Common substance-specific features of substance
intoxication
Substance
Common substance-specific features
Alcohol
Presenting features of alcohol intoxication may include impaired attention,
inappropriate or aggressive behaviour, lability of mood and emotions, impaired
judgement, poor coordination, unsteady gait, and slurred speech. At more severe
levels of intoxication, stupor or coma may occur.
Additional features
• Alcohol intoxication may be associated with impaired social interaction.
• Impaired coordination and judgement due to alcohol intoxication, even at low
doses, may be sufficiently severe to affect the faculties necessary to operate
motorized vehicles safely: alcohol intoxication is an important risk factor for road
accidents.
• The disinhibiting effects of alcohol are associated with an increased risk of
attempted and completed suicides.
• Higher blood levels of alcohol (e.g. >150 mg/dL) are associated with stupor and
coma. Blood levels of alcohol above 250 mg/dL can cause respiratory depression,
cardiac arrhythmias and death.
• Stupor and coma are more likely to occur in individuals with low tolerance or
comorbid medical conditions.
• The more severe the intoxication, the greater the likelihood of subsequent
amnesia for events that took place during the period of intoxication (“blackouts”).
• Some symptoms of intoxication with other substances (e.g. sedatives, hypnotics
or anxiolytics; opioids) may be similar to those of alcohol intoxication. Evidence of
alcohol use (e.g. the smell of alcohol on the breath) does not rule out concomitant
intoxication with other substances.
Cannabis or synthetic
cannabinoids
Presenting features of cannabis intoxication or synthetic cannabinoid intoxication
may include inappropriate euphoria, impaired attention, impaired judgement,
perceptual alterations (such as the sensation of floating, altered perception of
time), changes in sociability, increased appetite, anxiety, intensification of ordinary
experiences, impaired short-term memory and sluggishness. Physical signs include
conjunctival injection (red or bloodshot eyes), dry mouth and tachycardia.
Additional features
• The principal psychoactive cannabinoid is cannabis is THC. Disturbances in
consciousness, cognition, perception, affect, behaviour or coordination typical of
cannabis intoxication are primarily attributable to levels of THC, although various
other cannabinoids are also present in cannabis preparations (e.g. dried leaves
and buds, hashish, cannabis oil).
• Synthetic cannabinoid intoxication may cause delirium or acute psychosis.
• Regular intoxication with high potency cannabis or synthetic cannabinoids may be
associated with increased long-term risk of psychosis.
Note: medicinal cannabinoids such as cannabidiol and cannabinol – for example,
those used as antispasmodics, anxiolytics or analgesics – typically have no or
minimal intoxicating effects. However, standard laboratory testing for cannabinoids
may not be able to differentiate among these different types of cannabinoids.
Diagnostic requirements for disorders due to substance use | Substance intoxication
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Substance
Common substance-specific features
Opioids
Presenting features of opioid intoxication may include somnolence, stupor, mood
changes (e.g. euphoria followed by apathy and dysphoria), psychomotor retardation,
impaired judgement, respiratory depression, slurred speech, and impairment of
memory and attention. In severe intoxication, coma may ensue. A characteristic
physical sign is pupillary constriction, but this sign may be absent when intoxication
is due to synthetic opioids.
Additional features
• Severe opioid intoxication can lead to death due to excessive respiratory
depression. Overdose is more likely to occur with higher-potency opioids (e.g.
fentanyl), when the person has reduced tolerance (e.g. after detoxification)
or when an individual who has developed tolerance uses the opioid in a novel
environment.
• Opioid intoxication shares certain features with alcohol intoxication and sedative,
hypnotic or anxiolytic intoxication. Evidence of alcohol use (e.g. the smell of
alcohol on the breath) does not rule out co-occurring opioid intoxication.
• Where available, laboratory testing for substances that may be contributing to
the intoxication or their metabolites may be necessary to identify the intoxicating
substance.
• Administration of an opioid antagonist (e.g. naloxone) may be used empirically in
some settings (e.g. emergency settings) to differentiate opioid intoxication from
intoxication with other substances.
Sedatives, hypnotics or
anxiolytics
Presenting features of sedative, hypnotic or anxiolytic intoxication may include
somnolence, impaired judgement, inappropriate behaviour (including sexual
behaviour or aggression), slurred speech, impaired motor coordination, unsteady
gait, mood changes, and impaired memory, attention and concentration. Nystagmus
(repetitive, uncontrolled eye movements) is a common physical sign. In severe cases,
stupor or coma may occur.
Additional features
• Impaired memory in sedative, hypnotic or anxiolytic intoxication is characterized
by anterograde amnesia for the period of intoxication.
• Sedatives, hypnotics or anxiolytics are commonly prescribed medications. They
can cause intoxication even in therapeutic doses in older individuals and in those
with medical comorbidities.
• Some features of sedative, hypnotic or anxiolytic intoxication may be similar
to those of opioid intoxication or alcohol intoxication. Evidence of alcohol use
(e.g. the smell of alcohol on the breath) does not rule out concomitant sedative,
hypnotic or anxiolytic intoxication.
• Where available, laboratory testing for substances that may be contributing to
the intoxication or their metabolites may be necessary to identify the intoxicating
substance.
Cocaine
Presenting features of cocaine intoxication may include inappropriate euphoria,
anxiety, anger, impaired attention, hypervigilance, psychomotor agitation, paranoid
ideation (sometimes of delusional intensity), auditory hallucinations, confusion and
changes in sociability. Perspiration or chills, nausea or vomiting, and palpitations and
chest pain may be experienced. Physical signs may include tachycardia, elevated
blood pressure and pupillary dilatation.
Additional features
• In rare instances – usually in severe intoxication – cocaine use can result in
seizures, muscle weakness, dyskinesia and dystonia, and myocardial infarction
arising from coronary artery spasm or stroke arising from cerebral artery spasm.
Table 6.15. contd
Diagnostic requirements for disorders due to substance use | Substance intoxication
477
Disorders due to substance use or addictive behaviours
Substance
Common substance-specific features
Stimulants, including
amfetamines,
methamfetamine and
methcathinone
Presenting features of stimulant intoxication may include anxiety, anger, impaired
attention, hypervigilance, psychomotor agitation, paranoid ideation (possibly of
delusional intensity), transient auditory hallucinations, transient confusion and
changes in sociability. Perspiration or chills, nausea or vomiting, and palpitations may
be experienced. Physical signs may include tachycardia, elevated blood pressure,
pupillary dilatation, dyskinesia and dystonia, and skin sores.
Additional features
• In rare instances – usually in severe intoxication – use of stimulants, including
amfetamines, methamfetamine and methcathinone, can result in seizures.
Synthetic cathinones
Presenting features of synthetic cathinone intoxication may include anxiety, anger,
impaired attention, hypervigilance, psychomotor agitation, paranoid ideation
(possibly of delusional intensity), transient auditory hallucinations, transient
confusion and changes in sociability. Perspiration or chills, nausea or vomiting, and
palpitations may be experienced. Physical signs may include tachycardia, elevated
blood pressure, pupillary dilatation, dyskinesia and dystonia, and skin sores.
Additional features
• In rare instances – usually in severe intoxication – use of synthetic cathinones can
result in seizures.
Caffeine
Presenting features of caffeine intoxication may include restlessness, anxiety,
excitement,
insomnia,
flushed
face,
tachycardia,
diuresis,
gastrointestinal
disturbances, muscle twitching, psychomotor agitation, perspiration or chills, and
nausea or vomiting. Cardiac arrythmias may occur. Disturbances typical of caffeine
intoxication tend to occur at relatively high doses (e.g. >1 g per day).
Additional features
• Caffeine and related alkaloids (e.g. theobromine in tea) are present in a variety
of foods (e.g. chocolate, kola nuts), beverages (e.g. sodas, guarana) and
supplements (e.g. tablets, vitamins) that are consumed regularly and pervasively.
• Very high doses of caffeine (e.g. >5 g) can result in respiratory distress or seizures,
and can be fatal.
Hallucinogens
Presenting features of hallucinogen intoxication may include hallucinations, illusions,
perceptual changes such as depersonalization, derealization, synaesthesias
(blending of senses, such as a visual stimulus evoking a smell), anxiety, depressed
or dysphoric mood, ideas of reference, paranoid ideation, impaired judgement,
palpitations, sweating, blurred vision, tremors and lack of coordination. Physical
signs may include tachycardia, elevated blood pressure and pupillary dilatation.
Additional features
• In rare instances, hallucinogen intoxication may increase suicidal behaviour.
Table 6.15. contd
Diagnostic requirements for disorders due to substance use | Substance intoxication
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Substance
Common substance-specific features
Nicotine
Presenting features of nicotine intoxication may include restlessness, psychomotor
agitation, anxiety, cold sweats, headache, insomnia, palpitations, paraesthesias,
nausea or vomiting, abdominal cramps, confusion, bizarre dreams, burning
sensations in the mouth and salivation.
Additional features
• Nicotine intoxication occurs more commonly in people who have recently started
smoking or using other forms of nicotine (e.g. electronic cigarettes or “vaping”),
and have therefore not developed tolerance. It may also occur in people who
receive nicotine therapeutically and take it in higher than recommended doses.
• In rare instances, paranoid ideation, perceptual disturbances, convulsions or
coma may occur.
Volatile inhalants
Presenting features of volatile inhalant intoxication may include euphoria, impaired
judgement, aggression, somnolence, stupor or coma, dizziness, tremor, lack of
coordination, slurred speech, unsteady gait, lethargy and apathy, psychomotor
retardation and visual disturbance. Muscle weakness and diplopia may occur.
Additional features
• Intentional or unintentional exposure to a variety of volatile inhalant substances
(e.g. glue, petrol, butane, paint) can cause the symptoms of volatile inhalant
intoxication.
• Intentional volatile inhalant intoxication typically involves “sniffing” or “huffing” the
substances from closed containers, a practice that may lead to hypoxia, hypoxic
brain damage and other long-lasting neurological sequelae.
• Use of volatile inhalants may cause cardiac arrythmias, cardiac arrest and death.
• Inhalants containing lead (e.g. some forms of petrol/gasoline) may cause
confusion, irritability, coma and seizures.
• Use of volatile inhalants is more common among adolescents and young adults
due to the greater ease of access compared to other psychoactive substances.
MDMA or related drugs,
including MDA
Presenting features of MDMA or related drug intoxication may include increased
or inappropriate sexual interest and activity, anxiety, restlessness, agitation and
sweating.
Additional features
• In rare instances – usually in severe intoxication – use of MDMA or related drugs,
including MDA, can result in dystonia and seizures. Sudden death is a rare but
recognized complication.
Dissociative drugs,
including ketamine and
PCP
Presenting features of dissociative drug intoxication may include aggression,
impulsivity, unpredictable behaviour, anxiety, psychomotor agitation, impaired
judgement, numbness or diminished responsiveness to pain, slurred speech
and dystonia. Physical signs include nystagmus (repetitive, uncontrolled eye
movements), tachycardia, elevated blood pressure, numbness, ataxia, dysarthria
and muscle rigidity.
Additional features
• In rare instances, use of dissociative drugs, including ketamine and PCP, can
result in seizures.
• Laboratory tests to quantify PCP levels are only weakly correlated with
disturbances in consciousness, cognition, perception, affect, behaviour or
coordination.
Table 6.15. contd
Diagnostic requirements for disorders due to substance use | Substance intoxication

147 - Substance withdrawal
Substance withdrawal
479
Disorders due to substance use or addictive behaviours
Substance withdrawal
Available categories by substance class
6C40.4
Alcohol withdrawal
6C41.4
Cannabis withdrawal
6C42.4
Synthetic cannabinoid withdrawal
6C43.4
Opioid withdrawal
6C44.4
Sedative, hypnotic or anxiolytic withdrawal
6C45.4
Cocaine withdrawal
6C46.4
Stimulant withdrawal, including amfetamines, methamfetamine and
methcathinone
6C47.4
Synthetic cathinone withdrawal
6C48.3
Caffeine withdrawal
6C4A.4
Nicotine withdrawal
6C4B.4
Volatile inhalant withdrawal
6C4C.4
MDMA or related drug withdrawal, including MDA
6C4E.4
Other specified psychoactive substance withdrawal
6C4F.4
Multiple specified psychoactive substances withdrawal
6C4G.4
Withdrawal due to unknown or unspecified psychoactive substances
Essential (required) features
• The presentation is characterized by a clinically significant cluster of symptoms,
behaviours and/or physiological features that occurs upon cessation or reduction
in the use of a substance in individuals who have developed dependence on that
substance, or have used the substance for a prolonged period or in large amounts.
Note: substance withdrawal can occur when prescribed psychoactive medications (e.g.
opioids, anxiolytics, stimulants) have been used in standard therapeutic doses.
• The specific features of substance withdrawal depend on the pharmacological properties of
the specified substance (see Table 6.16, p. 484), and are consistent with those recognized as
occurring upon cessation or reduction of the particular substance or other members of the
same pharmacological group of substances. The symptoms also vary in degree of severity
and duration, depending on the substance and the amount and pattern of prior use.
• The symptoms are not better accounted for by another medical condition or another
mental disorder.
Note: substance withdrawal is only applicable for some substances or substance classes (see the list
above and Table 6.13, p. 450). Table 6.16 (p. 484) lists the most common symptoms, behaviours
and physiological features for each substance class.
Diagnostic requirements for disorders due to substance use | Substance withdrawal
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Specifiers for clinical presentation of substance withdrawal
Because of clinically important variation in their withdrawal syndromes, the following specifiers
can be applied to alcohol withdrawal (6C40.4) and sedatives, hypnotics or anxiolytics withdrawal
(6C44.4), as well as the withdrawal syndrome for other specified (6C4E.4), multiple (6C4F.4) and
unspecified (6C4G.4) psychoactive substance categories. The x below corresponds to the fourthcharacter code indicating the substance class (0 for alcohol, 1 for cannabis and so on).
Substance withdrawal, uncomplicated
All diagnostic requirements for substance withdrawal are met, and the withdrawal state is not
accompanied by perceptual disturbances or seizures.
Substance withdrawal, with perceptual disturbances
All diagnostic requirements for substance withdrawal are met, and the withdrawal state is
accompanied by perceptual disturbances (e.g. visual or tactile hallucinations or illusions) with
intact reality testing. There is no evidence of confusion, and other diagnostic requirements for
delirium are not met. The withdrawal state is not accompanied by seizures.
Substance withdrawal, with seizures
All diagnostic requirements for substance withdrawal are met, and the withdrawal state is
accompanied by seizures (i.e. generalized tonic-clonic seizures) but not by perceptual disturbances.
Substance withdrawal, with perceptual disturbances and seizures
All diagnostic requirements for substance withdrawal are met, and the withdrawal state is
accompanied by both seizures (i.e. generalized tonic-clonic seizures) and perceptual disturbances
(e.g. visual or tactile hallucinations or illusions) with intact reality testing. Diagnostic requirements
for delirium are not met.
Substance withdrawal, unspecified
6C4x.40
6C4x.41
6C4x.42
6C4x.43
6C4x.4Z
Diagnostic requirements for disorders due to substance use | Substance withdrawal
481
Disorders due to substance use or addictive behaviours
Additional clinical features for substance withdrawal
• For some substances, characteristic features of substance withdrawal are opposite to the acute
pharmacological effects of that substance (see Table 6.15, p. 475, and Table 6.16, p. 484).
• Substance withdrawal symptoms become more severe with repeated episodes of withdrawal
(termed “kindling”), with ageing, or in the presence of comorbid medical conditions.
• A diagnosis of substance withdrawal due to unknown or unspecified psychoactive
substances can be assigned if the substance consumed is initially unknown. As more
information becomes available (e.g. laboratory results, report from a collateral informant)
the diagnosis should be changed to indicate the substance responsible for the withdrawal
symptoms.
Boundary with normality (threshold)
• Substance withdrawal should only be diagnosed when symptoms are consistent with those
recognized as occurring upon cessation or reduction in use of the particular substance or
pharmacologically related group of substances (see Table 6.16, p. 484). Recent cessation
or reduction of use and the presence of various nonspecific transient symptoms is not
sufficient to make the diagnosis of substance withdrawal.
• Withdrawal symptoms should be differentiated from the transient physiological aftereffects
of intoxication (“hangover effect”). For example, if low mood and reduction in energy
are reported following use of alcohol; sedatives, hypnotics or anxiolytics; stimulants; or
MDMA or related drugs, and other characteristic features of substance withdrawal are
not present, a diagnosis of substance withdrawal should not be assigned. The presence of
a set of associated symptoms specific to different classes of psychoactive substances (see
Table 6.16, p. 484) – as well as the frequency, amount and duration of its use and presence
of substance dependence – should be considered in distinguishing substance withdrawal
from a “hangover effect”.
• Some individuals who have previously had substance dependence may experience
symptoms similar to those of substance withdrawal months after the last use of the
substance, particularly when the individual encounters stimuli (e.g. drug paraphernalia)
and contexts (e.g. location where use was frequent) previously associated with past
substance use. These symptoms are more transient than those observed during substance
withdrawal, and occur exclusively when in contact with associated stimuli and contexts.
A diagnosis of substance withdrawal should not be assigned under these circumstances.
Diagnostic requirements for disorders due to substance use | Substance withdrawal
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Course features
• Substance withdrawal is time-limited. Factors that influence the features and time course of
substance withdrawal include the severity of substance dependence (if present); the dose,
frequency of use and duration of use of the substance prior to cessation or reduction of
that use; the half-life and duration of action of the substance; and the presence of comorbid
medical conditions (e.g. metabolic disturbances).
Culture-related features
• Symptoms of withdrawal depend largely on the psychotropic characteristics of the
substance.
• However, specific cultures may emphasize certain symptoms of withdrawal over others,
making it more difficult to conduct a differential diagnosis. In addition, vernacular terms
for withdrawal vary greatly.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with substance dependence
Depending on the substance, many individuals with substance dependence develop substance
withdrawal upon cessation or reduction in the amount of the substance. In such cases, both
substance dependence and substance withdrawal should be diagnosed. However, substance
withdrawal can be diagnosed in the absence of a diagnosis of substance dependence – for
example, in response to cessation of medically appropriate treatment with opioid analgesics that
is not accompanied by the other essential features of substance dependence.
Boundary with substance intoxication
The onset of substance intoxication occurs immediately or shortly after the consumption of a
substance. In contrast, substance withdrawal occurs upon cessation or reduction in the amount
of a substance in the context of substance dependence, or when a substance has been taken for a
prolonged period or in large amounts. For a particular substance, the intoxication and withdrawal
syndromes are typically distinct. See Table 6.15 (p. 475) for a description of the substance-specific
features of substance intoxication and Table 6.16 (p. 484) for a description of the substancespecific features of substance withdrawal.
Boundary with substance-induced delirium
Delirium is characterized by disturbances in attention, orientation and awareness that develop
within a short period of time, with symptoms that are transient and may fluctuate depending
Diagnostic requirements for disorders due to substance use | Substance withdrawal
483
Disorders due to substance use or addictive behaviours
on the underlying etiology. Delirium often includes disturbance of behaviour and emotion, and
may include impairment in multiple cognitive domains. Disturbance of the sleep-wake cycle may
also be present. Delirium may occur as an aspect of substance withdrawal, particularly during
later stages of withdrawal. In such cases, diagnoses of both substance withdrawal and substanceinduced delirium should be assigned. Note: substance-induced delirium is only applicable for
some substances or substance classes (see Table 6.14, p. 454).
Boundary with other substance-induced mental disorders
Mental or behavioural symptoms that arise during substance withdrawal should only be used
as a basis for diagnosing a substance-induced mental disorder if the intensity or duration of the
symptoms is substantially in excess of those that are characteristic of the substance withdrawal
due to the specified substance (see Table 6.16, p. 484), and the symptoms are sufficiently severe to
warrant specific clinical attention. In such cases, if the withdrawal syndrome is ongoing, diagnoses
of both substance withdrawal and a substance-induced mental disorder may be assigned.
Boundary with other mental disorders
Various symptoms associated with substance withdrawal overlap with those that are characteristic
of other mental disorders (e.g. depressive and anxiety symptoms). Symptoms of substance
withdrawal occur in specific temporal relationship to the cessation of use of a specific substance,
and diminish with the passage of time. Evidence supporting a mental disorder diagnosis would
include the symptoms preceding the onset of the substance use, the symptoms persisting for
a substantial period of time after cessation of the substance or medication use or withdrawal
(e.g. 1 month or more, depending on the substance), or other evidence of a pre-existing mental
disorder (e.g. a history of prior episodes not associated with substance use).
Boundary with other medical conditions
It may be difficult to distinguish between various symptoms associated with substance withdrawal
(e.g. nausea, retching or vomiting, seizures, abdominal cramps, diarrhoea, perspiration, postural
hypotension, decreased or increased heart rate, cough, sleep disruption) and those that are
characteristic of other medical conditions. Symptoms of substance withdrawal occur in specific
temporal relationship to the cessation of use of a specific substance and diminish with the passage
of time.
Boundary with fetus or newborn affected by maternal use of tobacco, alcohol, or
other drugs of addiction
Chapter 19 on certain conditions arising during the perinatal period contains a category of fetus
or newborn affected by maternal use of tobacco, alcohol and other drugs. A neonate exhibiting
signs of substance withdrawal related to a specific substance may also be assigned the appropriate
substance withdrawal diagnosis in order to guide treatment together with appropriate diagnosis
from Chapter 19.
Substance withdrawal is a cluster of symptoms, behaviours and physiological features, varying in
degree of severity and duration, that occur upon cessation or reduction of use of a psychoactive
substance in individuals who have developed dependence on that substance, or who have taken
the substance for a prolonged period or in large amounts. The diagnosis of substance withdrawal
is applicable only to certain substances and substance groups (see Table 6.13, p. 450). Specific
presenting features that may occur as a part of substance withdrawal for each applicable class of
psychoactive substances in the grouping of disorders due to substance use are listed in Table 6.16.
Diagnostic requirements for disorders due to substance use | Substance withdrawal
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.16. Common substance-specific features of substance
withdrawal
Substance
Substance-specific features of withdrawal
Alcohol
Presenting features of alcohol withdrawal may include autonomic hyperactivity
(e.g. tachycardia, hypertension, perspiration), increased hand tremor, nausea, retching
or vomiting, insomnia, anxiety, psychomotor agitation, depressed or dysphoric mood,
transient visual, tactile or auditory illusions or hallucinations, and distractibility.
Less commonly, alcohol withdrawal is complicated by seizures.
Additional features
• Onset of alcohol withdrawal typically occurs within 6–12 hours after last use, as
blood alcohol concentrations decline. Symptoms vary in type, severity, onset and
duration, according to the duration and intensity of alcohol use prior to cessation
or reduction of use.
• Features of mild or moderate withdrawal typically last for 3–7 days after cessation
of alcohol use, and include autonomic hyperactivity, increased hand tremor, anxiety,
insomnia, nausea, vomiting and headache. Features of moderate withdrawal
may also include transient visual, tactile or auditory illusions or hallucinations,
distractibility and psychomotor agitation.
• In 1–3% of cases, alcohol withdrawal is complicated by seizures of a tonic-clonic type.
When seizures occur, they are usually single seizures with onset within 6–48 hours
after last use. Evidence of a premorbid seizure disorder, other intracranial pathology
or co-occurring use of other substances does not preclude a presumptive alcohol
withdrawal diagnosis.
• Approximately 2% of cases of alcohol withdrawal progress to a very severe syndrome
sometimes referred to as “delirium tremens” (or DTs), characterized by confusion
and disorientation, delusions and prolonged visual, tactile or auditory hallucinations.
When delirium is present, a separate diagnosis of 6C40.5 Alcohol-induced delirium
should also be assigned. The presence of seizures during withdrawal represents a
risk factor for development of delirium. If unrecognized or untreated, delirium during
alcohol withdrawal is associated with substantially increased mortality compared to
alcohol withdrawal without co-occurring delirium.
• Some symptoms associated with alcohol withdrawal – such as autonomic
hyperactivity, anxiety and insomnia – can recur or persist for several months after
abstinence, particularly when the person is exposed to alcohol-associated cues
(a conditioned withdrawal state). The presence of such persisting symptoms is not
sufficient to meet diagnostic requirements for alcohol withdrawal.
Cannabis
Presenting features of cannabis withdrawal may include irritability, anger or aggressive
behaviour, shakiness, insomnia, restlessness, anxiety, depressed or dysphoric mood,
decreased appetite and weight loss, headache, sweating or chills, abdominal cramps
and muscle aches.
Additional features
• The occurrence, severity and duration of cannabis withdrawal vary according to the
type and potency of the cannabis preparation, as well as the amount, frequency and
duration of use before cessation or reduction of use.
• Onset of cannabis withdrawal typically occurs at some point between 12 hours and
3 days after cessation or reduction of use. Symptom severity typically peaks at
4–7 days and may last for 1–3 weeks after cessation of use. However, cannabis
withdrawal may also be briefer, in some cases lasting only a few days.
• When cannabis withdrawal occurs in the context of a co-occurring mental disorder,
the features of the other disorder (e.g. fluctuation of mood) may be exacerbated.
Diagnostic requirements for disorders due to substance use | Substance withdrawal
485
Disorders due to substance use or addictive behaviours
Substance
Substance-specific features of withdrawal
Synthetic
cannabinoids
Presenting features of synthetic cannabinoid withdrawal may include irritability,
anger, aggression, shakiness, insomnia and disturbing dreams, restlessness, anxiety,
depressed or dysphoric mood and appetite disturbance. In the early phase, synthetic
cannabinoid withdrawal may be accompanied by residual features of intoxication from
the drug, such as paranoid ideation and auditory and visual hallucinations.
Additional features
• The occurrence, severity and duration of synthetic cannabinoid withdrawal vary
according to the type and potency of the synthetic cannabinoid used, as well as the
amount, frequency and duration of use before cessation or reduction of use.
• Synthetic cannabinoid withdrawal typically lasts for 1–3 weeks after cessation
of use.
Opioids
Presenting features of opioid withdrawal may include depressed or dysphoric mood,
craving for an opioid, anxiety, nausea or vomiting, abdominal cramps, muscle aches,
yawning, perspiration, hot and cold flushes, hypersomnia (typically in the initial phase)
or insomnia, diarrhoea, piloerection and pupillary dilation.
Additional features
• The severity and time course of opioid withdrawal is influenced by many factors
that include the type of opioid taken, its half-life and duration of action, the amount,
frequency and duration of opioid use before cessation or reduction of use, prior
experience of opioid withdrawal, and expectations of the severity of the syndrome.
• Opioid withdrawal from short-acting opioids such as injected heroin or morphine
typically begins within 4–12 hours of cessation of use and lasts for 4–10 days.
• Opioid withdrawal from longer-acting opioids such as codeine, oxycodone and
similar pharmaceutical agents may not be evident for 2–4 days and may last for
1–2 weeks.
• The withdrawal state from long-acting drugs such as methadone may persist for up
to 2 months after cessation of use.
• Opioid withdrawal occurs in phases. The early phase typically includes lacrimation,
rhinorrhoea and yawning. This is followed by hot and cold flashes, muscle aching and
abdominal cramps, nausea and vomiting and diarrhoea; piloerection and pupillary
dilatation may also occur. The later phase is dominated by craving for opioids.
• Recurrence or worsening of pain may occur if the opioid was used to manage
chronic pain.
• Serious medical complications of opioid withdrawal are rare. Fluid depletion may
occasionally lead to renal impairment. Death during opioid withdrawal is very
uncommon.
Table 6.16. contd
Diagnostic requirements for disorders due to substance use | Substance withdrawal
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Substance
Substance-specific features of withdrawal
Sedatives, hypnotics
or anxiolytics
Presenting features of sedative, hypnotic or anxiolytic withdrawal may include anxiety,
psychomotor agitation, insomnia, increased hand tremor, nausea or vomiting, and
transient visual, tactile or auditory illusions or hallucinations. There may be signs of
autonomic hyperactivity (e.g. tachycardia, hypertension, perspiration) or postural
hypotension. The withdrawal state may be complicated by seizures.
Additional features
• The severity and time course of sedative, hypnotic or anxiolytic withdrawal is
related to the particular substance taken, its half-life and duration of action, and the
amount, frequency and duration of use before cessation or reduction of use.
• The withdrawal state associated with short-acting drugs typically has its onset
within 12–24 hours after cessation of use and has a course of up to 14 days.
Withdrawal onset may be delayed by 3–5 days with longer-acting drugs and may
persist for several weeks.
• Sedative, hypnotic or anxiolytic withdrawal may be complicated by seizures, which
are of a tonic-clonic type and may be single or multiple.
• Sedative, hypnotic or anxiolytic withdrawal, especially when untreated, may progress
to a very severe form of delirium, characterized by confusion and disorientation,
delusions, and more prolonged visual, tactile or auditory hallucinations. In such
cases, a separate diagnosis of 6C44.5 Sedative, hypnotic or anxiolytic-induced
delirium should also be assigned.
• Medical sequelae of complicated withdrawal include status epilepticus, respiratory
compromise and renal failure.
• Some features of sedative, hypnotic or anxiolytic withdrawal – such as anxiety,
transient illusions or hallucinations, and derealization – may persist for several
months after cessation of use.
Cocaine
Presenting features of cocaine withdrawal may include depressed or dysphoric mood,
irritability, fatigue, psychomotor agitation or retardation, vivid unpleasant dreams,
insomnia or hypersomnia, increased appetite, anxiety and craving for cocaine.
Additional features
• Initial symptoms of cocaine withdrawal include a dysphoric and low energy
state manifested in depressed or dysphoric mood, irritability, fatigue, inertia and
hypersomnia. This typically occurs within 6–24 hours of cessation of cocaine use.
• The withdrawal state may last up to 7 days. Craving for cocaine is prominent in the
later stages.
• Suicidal ideation may occur, especially when dysphoric mood is marked.
• At the onset of cocaine withdrawal there may be features that persist from the
intoxicating effects of cocaine, such as hyperactivity, paranoid ideation and
auditory hallucinations.
Stimulants, including
amfetamines,
methamfetamine and
methcathinone
Presenting features of stimulant withdrawal may include depressed or dysphoric mood,
irritability, fatigue, insomnia or (more commonly) hypersomnia, vivid and unpleasant
dreams, increased appetite, psychomotor agitation or retardation, and craving for
amfetamine and related stimulants.
Additional features
• Stimulant withdrawal typically occurs within 24 hours to 4 days of cessation of
stimulant use, and is characterized by a dysphoric and low energy state manifested
in depressed or dysphoric mood, irritability, fatigue, inertia and hypersomnia.
• The severity and duration of the withdrawal state is widely variable based on the
type of stimulant taken and the amount, frequency and duration of such use prior
to its cessation.
• In the first phase of stimulant withdrawal, which typically lasts for 7–14 days, low
mood, lethargy and hypersomnia predominate. After this phase, irritability and
craving for stimulants are prominent and may persist for 6–8 weeks.
• At the onset of stimulant withdrawal there may be features that persist from the
intoxicating effects of the stimulant, such as hyperactivity, paranoid ideation and
auditory hallucinations.
Table 6.16. contd
Diagnostic requirements for disorders due to substance use | Substance withdrawal
487
Disorders due to substance use or addictive behaviours
Substance
Substance-specific features of withdrawal
Synthetic cathinones
Presenting features of synthetic cathinone withdrawal may include depressed or
dysphoric mood, irritability, fatigue, insomnia or (more commonly) hypersomnia, vivid
and unpleasant dreams, increased appetite, psychomotor agitation or retardation, and
craving for stimulants, including synthetic cathinones.
Caffeine
Presenting features of caffeine withdrawal may include headache, marked fatigue
or drowsiness, irritability, depressed or dysphoric mood, nausea or vomiting, and
difficulty concentrating.
Additional features:
• The severity and duration of caffeine withdrawal is related to the amount, frequency
and duration of caffeine use prior to cessation of use.
• Onset of caffeine withdrawal is typically 12–48 hours after the last use and may last
up to 7 days.
Nicotine
Presenting features of nicotine withdrawal may include depressed or dysphoric mood,
insomnia, irritability, anger, anxiety, difficulty concentrating, restlessness, bradycardia,
increased appetite, and craving for tobacco or other nicotine-containing products.
Other physical symptoms may include increased cough and mouth ulceration.
Additional features:
• The severity and duration of nicotine withdrawal is variable, related to the amount,
frequency and duration of tobacco smoked (or otherwise consumed) or of nicotine
products taken prior to cessation of use.
• Onset of nicotine withdrawal is typically 6–24 hours after cessation or reduction of
use. Psychological and physiological features typically last up to 10 days. Physical
features such as increased cough and mouth ulceration may persist for 2–3 weeks.
• Craving for tobacco (or other nicotine-containing products) is prominent throughout
the duration of nicotine withdrawal.
Volatile inhalants
Presenting features of volatile inhalant withdrawal may include insomnia, anxiety,
irritability, depressed or dysphoric mood, shakiness, perspiration, nausea and transient
illusions.
Additional features:
• The severity and duration of volatile inhalant withdrawal is related to the type of
inhalant used and to the amount, frequency and duration of use of the specific
inhalant.
• Volatile inhalant withdrawal may be accompanied by persisting features
of volatile inhalant intoxication or its medical
complications, such as
encephalopathy – especially when the inhalant used is lead-containing petrol/gasoline.
MDMA or related
drugs, including MDA
Presenting features of MDMA or related drug withdrawal may include fatigue, lethargy,
hypersomnia or insomnia, depressed mood, anxiety, irritability, craving, difficulty in
concentrating and appetite disturbance.
Additional features
• The above information primarily concerns withdrawal from MDMA. There is
insufficient information on the features and course of the withdrawal state from
drugs related to MDMA, including MDA, to fully characterize the associated
withdrawal states.
• MDMA withdrawal is uncommon, reflecting the comparative rarity of MDMA
dependence.
• Onset of MDMA withdrawal typically occurs within 12–24 hours after last use,
as blood concentrations decline. The features vary in type, severity, onset and
duration according to the amount, frequency and duration of MDMA use prior to
cessation of use.
• The duration of MDMA withdrawal may be up to 10 days. Craving for MDMA may be
prominent during the later stages.
Table 6.16. contd
Diagnostic requirements for disorders due to substance use | Substance withdrawal

148 - Substance induced mental disorders
Substance-induced mental disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Substance-induced mental disorders
Substance-induced mental disorders are characterized by psychological, cognitive or behavioural
symptoms that develop during or soon after psychoactive substance intoxication or withdrawal,
or use or discontinuation of a psychoactive medication. The duration or severity of the symptoms
is substantially in excess of the characteristic syndrome of substance intoxication or substance
withdrawal due to the specified substance.
Substance-induced mental disorders include:
Substance-induced delirium
Substance-induced psychotic disorder
• with hallucinations
• with delusions
• with mixed psychotic symptoms
Substance-induced mood disorder
• with depressive symptoms
• with manic symptoms
• with mixed depressive and manic symptoms
Substance-induced anxiety disorder
Substance-induced obsessive-compulsive or related disorder
Substance-induced impulse control disorder.
Specific types of substance-induced mental disorders are only applicable for some substance
classes, which are listed along with corresponding codes in the sections on specific substanceinduced mental disorders below, as well as in Table 6.14 (p. 454). Specific substance-induced mental
disorders may characteristically have their onset during or soon after substance intoxication and/
or substance withdrawal for specific substances or substance classes.
When making a diagnosis of substance-induced mental disorder, an additional diagnosis
indicating the related pattern of substance use should also be assigned. These include episode of
harmful psychoactive substance use, harmful pattern of psychoactive substance use and substance
dependence. A diagnosis of substance intoxication or substance withdrawal may also be assigned
if applicable.
Additional categories of substance-induced disorders are included in other groupings of this
chapter on mental, behavioural and neurodevelopmental disorders, and CDDR are provided in the
corresponding sections. These categories are cross-listed in this section for reference, and include:
6A41
Catatonia induced by substances or medications (p. 204).
6D70.1
Delirium due to psychoactive substances, including medications (p. 606).
6D72.1
Amnestic disorder due to psychoactive substances, including medications
(p. 616).
6D84
Dementia due to psychoactive substances, including medications (p. 626).
Essential features for each substance-induced mental disorder category are provided below,
as are any specifiers corresponding to specific disorders. Other CDDR elements – additional
clinical features, boundary with normality (threshold) and boundaries with other disorders and
conditions (differential diagnosis) – apply to all substance-induced mental disorder categories
and are provided at the end of this section.
Diagnostic requirements for disorders due to substance use | Substance-induced mental disorders

149 - Substance induced delirium
Substance-induced delirium

15 - 8A05.02 Chronic phonic tic disorder
8A05.02  Chronic phonic tic disorder
157
Neurodevelopmental disorders
Boundary with obsessive-compulsive disorder
Repetitive, recurrent movements or vocalizations can also be symptomatic of obsessive-compulsive
disorder. Tics can be differentiated from obsessive-compulsive disorder because they appear
unintentional in nature and clearly utilize a discrete muscle group. However, it can be difficult to
distinguish between complex tics and compulsions associated with obsessive-compulsive disorder.
Although tics (both complex and simple) are preceded by premonitory sensory urges, which may
diminish over time, tics are not aimed at neutralizing antecedent cognitions (e.g. obsessions) or
reducing physiological arousal (e.g. anxiety). Many individuals exhibit symptoms of both obsessivecompulsive disorder and Tourette syndrome, and both diagnoses may be assigned if the diagnostic
requirements for each are met.
Boundary with self-injurious and self-mutilating behaviours
With enough force and repetition, motor tics may lead to self-injury. However, unlike self-injurious
and self-mutilating behaviour, Tourette syndrome is not associated with an intention to cause
self-injury.
Chronic motor tic disorder
Essential (required) features
• The persistent presence of motor tics is required for diagnosis.
• Motor tics are defined as sudden, rapid, non-rhythmic and recurrent movements.
• Motor tics have been present for at least 1 year, with onset during the developmental period.
Note: other CDDR elements for chronic motor tic disorder are provided below, following the
essential features for chronic phonic tic disorder.
Chronic phonic tic disorder
Essential (required) features
• The persistent presence of phonic tics is required for diagnosis.
• Phonic tics are defined as sudden, rapid, non-rhythmic and recurrent vocalizations.
• Phonic tics have been present for at least 1 year, with onset during the developmental period.
8A05.01
8A05.02
Neurodevelopmental disorders | Secondary-parented categories in neurodevelopmental disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features for chronic motor tic disorder and chronic
phonic tic disorder
• Motor and phonic tics may be voluntarily suppressed for short periods of time, may
be exacerbated by stress, and may diminish during sleep or during periods of focused
enjoyable activity.
• Tics are often highly suggestible – for example, when an individual with chronic motor tic
disorder or chronic phonic tic disorder is asked about specific symptoms, old tics that have
been absent for some time may transiently reappear.
Boundary with normality (threshold) for chronic motor tic disorder
and chronic phonic tic disorder
• Transient motor or phonic tics (e.g. eye blinking, throat clearing) are common during
childhood, and are differentiated from chronic motor tic disorder and chronic phonic tic
disorder by their transient nature.
Developmental presentations for chronic motor tic disorder and
chronic phonic tic disorder
• The prevalence of chronic motor tic disorder is estimated at between 0.3% and 0.8% of
school-aged children.
• Less is known about the prevalence of chronic phonic tic disorder.
Culture-related features for chronic motor tic disorder and chronic
phonic tic disorder
• If vocalizations or movements have a specific function or meaning in the context of an
individual’s culture and are used in ways that are consistent with that cultural function or
meaning, they should not be considered evidence of chronic motor tic disorder or chronic
phonic tic disorder.
Neurodevelopmental disorders | Secondary-parented categories in neurodevelopmental disorders
159
Neurodevelopmental disorders
Sex- and/or gender-related features for chronic motor tic disorder
and chronic phonic tic disorder
• Women with persistent tic disorders may be more likely to experience co-occurring anxiety
and fear-related disorders and depressive disorders.
Boundaries with other disorders and conditions (differential
diagnosis) for chronic motor tic disorder and chronic phonic
tic disorder
Boundary with autism spectrum disorder and stereotyped movement disorder
Repetitive and stereotyped motor movements such as whole-body movements (e.g. rocking) and
unusual hand or finger movements can be a characteristic feature of autism spectrum disorder and
of stereotyped movement disorder. These behaviours can appear similar to tics but are differentiated
because they tend to be more stereotyped, last longer than the duration of a typical tic, tend to emerge
at a younger age, are not characterized by premonitory sensory urges, are often experienced by the
individual as soothing or rewarding, and can generally be interrupted with distraction.
Boundary with obsessive-compulsive disorder
Repetitive, recurrent movements or vocalizations can also be symptomatic of obsessive-compulsive
disorder. Tics can be differentiated from obsessive-compulsive disorder because they appear
unintentional in nature and clearly utilize a discrete muscle group. However, it can be difficult to
distinguish between complex tics and compulsions associated with obsessive-compulsive disorder.
Although tics (both complex and simple) are preceded by premonitory sensory urges, which may
diminish over time, tics are not aimed at neutralizing antecedent cognitions (e.g. obsessions) or
reducing physiological arousal (e.g. anxiety). Many individuals exhibit symptoms of both obsessivecompulsive disorder and chronic motor tic disorder or chronic phonic tic disorder, and both
diagnoses may be assigned if the diagnostic requirements for each are met.
Boundary with self-injurious and self-mutilating behaviours
With enough force and repetition, motor tics may lead to self-injury. However, unlike self-injurious
and self-mutilating behaviour, chronic motor tic disorder is not associated with an intention to
cause self-injury.
Neurodevelopmental disorders | Secondary-parented categories in neurodevelopmental disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

150 - Substance induced psychotic disorders
Substance-induced psychotic disorders
489
Disorders due to substance use or addictive behaviours
Substance-induced delirium
Available categories by substance class
6C40.5
Alcohol-induced delirium
6C41.5
Cannabis-induced delirium
6C42.5
Synthetic cannabinoid-induced delirium
6C43.5
Opioid-induced delirium
6C44.5
Sedative, hypnotic or anxiolytic-induced delirium
6C45.5
Cocaine-induced delirium
6C46.5
Stimulant-induced delirium, including amfetamines, methamfetamine and
methcathinone
6C47.5
Synthetic cathinone-induced delirium
6C49.4
Hallucinogen-induced delirium
6C4B.5
Volatile inhalant-induced delirium
6C4C.5
MDMA or related drug-induced delirium, including MDA
6C4D.4
Dissociative drug-induced delirium, including ketamine and PCP
6C4E.5
Delirium induced by other specified psychoactive substances, including
medications
6C4F.5
Delirium induced by multiple specified psychoactive substances, including
medications
6C4G.5
Delirium induced by unknown or unspecified psychoactive substances
CDDR for substance-induced delirium are provided as part of the grouping of neurocognitive
disorders (delirium due to psychoactive substances, including medications, p. 606).
Substance-induced psychotic disorders
Available categories by substance class
6C40.6
Alcohol-induced psychotic disorder
6C41.6
Cannabis-induced psychotic disorder
6C42.6
Synthetic cannabinoid-induced psychotic disorder
6C43.6
Opioid-induced psychotic disorder
6C44.6
Sedative, hypnotic or anxiolytic-induced psychotic disorder
6C45.6
Cocaine-induced psychotic disorder
6C46.6
Stimulant-induced
psychotic
disorder,
including
amfetamines,
methamfetamine and methcathinone
6C47.6
Synthetic cathinone-induced psychotic disorder
6C49.5
Hallucinogen-induced psychotic disorder
6C4B.6
Volatile inhalant-induced psychotic disorder
6C4C.6
MDMA or related drug-induced psychotic disorder, including MDA
6C4D.5
Dissociative drug-induced psychotic disorder, including ketamine and PCP
6C4E.6
Psychotic disorder induced by other specified psychoactive substance
6C4F.6
Psychotic disorder induced by multiple specified psychoactive substances
6C4G.6
Psychotic disorder induced by unknown or unspecified psychoactive
substances
Substance-induced mental disorders | Delirium | Psychotic disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Essential (required) features
• The presentation is characterized by psychotic symptoms (e.g. delusions, hallucinations
or disorganized thinking or behaviour) that develop during or soon after intoxication
with or withdrawal from a specified substance, or use or discontinuation of a psychoactive
medication.
• The intensity or duration of the psychotic symptoms is substantially in excess of psychoticlike disturbances of perception, cognition or behaviour that are characteristic of intoxication
or withdrawal due to the specified substance.
• The specified substance, as well as the amount and duration of its use, is known to be
capable of producing psychotic symptoms (see the list above and Table 6.14, p. 454).
• The symptoms are not better accounted for by another mental disorder such as schizophrenia
or a mood disorder with psychotic symptoms. Evidence supporting a diagnosis of
another mental disorder would include psychotic symptoms preceding the onset of the
substance use, the symptoms persisting for a substantial period of time after cessation of
the substance, or medication use or withdrawal (e.g. 1 month or more depending on the
specific substance), or other evidence of a pre-existing mental disorder with psychotic
symptoms (e.g. a history of prior episodes not associated with substance use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning.
Specifiers for substance-induced psychotic symptoms
An additional specifier can be added to denote the presence of hallucinations, delusions, or
mixed psychotic symptoms for alcohol-induced psychotic disorder (6C40.6), cocaine-induced
psychotic disorder (6C45.6), stimulant-induced psychotic disorder, including amfetamines,
methamfetamine or methcathinone (6C46.6), and synthetic cathinone-induced psychotic
disorder (6C47.6). The x below corresponds to the fourth-character code indicating the substance
class (0 for alcohol, 1 for cannabis and so on) (see the list above and Table 6.14, p. 454).
Substance-induced psychotic disorder with hallucinations
• All diagnostic requirements for substance-induced psychotic disorder are met.
• The presentation is characterized by hallucinations that are judged to be the direct
consequence of the use of or withdrawal from a specified substance or medication.
• Neither delusions nor other psychotic symptoms are present.
• The symptoms do not occur exclusively during hypnogogic or hypnopompic states.
Substance-induced mental disorders | Psychotic disorders
6C4x.60

151 - Substance induced mood disorders
Substance-induced mood disorders
491
Disorders due to substance use or addictive behaviours
Substance-induced mood disorders
Substance-induced psychotic disorder with delusions
• All diagnostic requirements for substance-induced psychotic disorder are met.
• The presentation is characterized by delusions that are judged to be the direct consequence
of use of or withdrawal from a specified substance or medication.
• Neither hallucinations nor other psychotic symptoms are present.
Substance-induced psychotic disorder with mixed psychotic symptoms
• All diagnostic requirements for substance-induced psychotic disorder are met.
• The presentation is characterized by multiple psychotic symptoms, primarily hallucinations
and delusions, when these are judged to be the direct consequence of the use of or
withdrawal from a specified substance or medication.
Substance-induced psychotic disorder, unspecified
Substance-induced mood disorders
Available categories by substance class
6C40.70
Alcohol-induced mood disorder
6C41.70
Cannabis-induced mood disorder
6C42.70
Synthetic cannabinoid-induced mood disorder
6C43.70
Opioid-induced mood disorder
6C44.70
Sedative, hypnotic or anxiolytic-induced mood disorder
6C45.70
Cocaine-induced mood disorder
6C46.70
Stimulant-induced mood disorder, including amfetamines, methamfetamine
and methcathinone
6C47.70
Synthetic cathinone-induced mood disorder
6C49.60
Hallucinogen-induced mood disorder
6C4B.70
Volatile inhalant-induced mood disorder
6C4C.70
MDMA or related drug-induced mood disorder, including MDA
6C4D.60
Dissociative drug-induced mood disorder, including ketamine and PCP
6C4E.70
Mood disorder induced by other specified psychoactive substance
6C4F.70
Mood disorder induced by multiple specified psychoactive substances
6C4G.70
Mood disorder induced by unknown or unspecified psychoactive substances
Essential (required) features
• The presentation is characterized by mood symptoms (e.g. depressed or elevated mood,
decreased engagement in pleasurable activities, increased or decreased energy levels) that
6C4x.62
6C4x.6Z
6C4x.61
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
develop during or soon after intoxication, with or withdrawal from a specified substance
or use or discontinuation of a psychoactive medication.
• The intensity or duration of the mood symptoms is substantially in excess of mood symptoms
that are characteristic of intoxication or withdrawal due to the specified substance.
• The specified substance, as well as the amount and duration of its use, is known to be
capable of producing mood symptoms (see the list above and Table 6.14, p. 454).
• The symptoms are not better accounted for by another mental disorder such as a
depressive disorder, a bipolar disorder, or schizophrenia or another primary psychotic
disorder. Evidence supporting a diagnosis of another mental disorder would include
mood symptoms preceding the onset of the substance use, the symptoms persisting for a
substantial period of time after cessation of the substance or medication use or withdrawal
(e.g. 1 month or more depending on the specific substance), or other evidence of a
pre-existing mental disorder with mood symptoms (e.g. a history of prior episodes not
associated with substance use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. If functioning is
maintained, it is only through significant additional effort.
Specifiers for substance-induced mood symptoms
An additional specifier can be added to denote the presence of depressive symptoms in the
absence of manic symptoms, manic symptoms in the absence of depressive symptoms, or
mixed manic and depressive symptoms. The x below corresponds to the fourth-character
code indicating the substance class (0 for alcohol, 1 for cannabis and so on). The y represents
the character that correspond to substance-induced mood disorder for that class of substances
(see the list above and Table 6.14, p. 454). For example, 6C40.700 is alcohol-induced mood
disorder with depressive symptoms and 6C4D.602 is dissociative drug-induced mood
disorder with mixed depressive and manic symptoms.
Substance-induced mood disorder with depressive symptoms
• All diagnostic requirements for substance-induced mood disorder are met.
• The presentation is characterized by depressive symptoms judged to be the direct
consequence of the use of or withdrawal from a specified substance or medication.
• Manic symptoms are not present.
Substance-induced mood disorder with manic symptoms
• All diagnostic requirements for substance-induced mood disorder are met.
• The presentation is characterized by manic symptoms judged to be the direct consequence
of the use of or withdrawal from a specified substance or medication.
• Depressive symptoms are not present.
6C4x.y01
6C4x.y00
Substance-induced mood disorders

152 - Substance induced anxiety disorders
Substance-induced anxiety disorders
493
Disorders due to substance use or addictive behaviours
Substance-induced mood disorder with mixed depressive and manic symptoms
• All diagnostic requirements for substance-induced mood disorder are met.
• The presentation is characterized by both depressive and manic symptoms judged to be the
direct consequence of the use of or withdrawal from a specified substance or medication.
Substance-induced mood disorder, unspecified
Substance-induced anxiety disorders
Available categories by substance class
6C40.71
Alcohol-induced anxiety disorder
6C41.71
Cannabis-induced anxiety disorder
6C42.71
Synthetic cannabinoid-induced anxiety disorder
6C43.71
Opioid-induced anxiety disorder
6C44.71
Sedative, hypnotic or anxiolytic-induced anxiety disorder
6C45.71
Cocaine-induced anxiety disorder
6C46.71
Stimulant-induced anxiety disorder, including amfetamines, methamfetamine
and methcathinone
6C47.71
Synthetic cathinone-induced anxiety disorder
6C48.40
Caffeine-induced anxiety disorder
6C49.61
Hallucinogen-induced anxiety disorder
6C4B.71
Volatile inhalant-induced anxiety disorder
6C4C.71
MDMA or related drug-induced anxiety disorder, including MDA
6C4D.61
Dissociative-induced anxiety disorder, including ketamine and PCP
6C4E.71
Anxiety disorder induced by other specified psychoactive substance
6C4F.71
Anxiety disorder induced by multiple specified psychoactive substances
6C4G.71
Anxiety disorder induced by unknown or unspecified psychoactive substances
Essential (required) features
• The presentation is characterized by anxiety symptoms (e.g. apprehension or worry,
fear, physiological symptoms of excessive autonomic arousal, panic attacks, avoidance
behaviour) that develop during or soon after intoxication with or withdrawal from a
specified substance, or use or discontinuation of a psychoactive medication.
• The intensity or duration of the anxiety symptoms is substantially in excess of anxiety
symptoms that are characteristic of intoxication or withdrawal due to the specified
substance.
• The specified substance, as well as the amount and duration of its use, is known to be
capable of producing anxiety symptoms (see the list above and Table 6.14, p. 454).
• The symptoms are not better accounted for by another mental disorder such as an anxiety
or fear-related disorder, a depressive disorder with prominent anxiety symptoms, or posttraumatic stress disorder. Evidence supporting a diagnosis of another mental disorder
6C4x.y02
6C4x.y0Z
Substance-induced anxiety disorders

153 - Substance induced obsessive compulsive and re
Substance-induced obsessive-compulsive and related disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
would include anxiety symptoms preceding the onset of the substance use, the symptoms
persisting for a substantial period of time after cessation of the substance or medication
use or withdrawal (e.g. 1 month or more depending on the specific substance), or other
evidence of a pre-existing mental disorder with anxiety symptoms (e.g. a history of prior
episodes not associated with substance use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. If functioning is
maintained, it is only through significant additional effort.
Substance-induced obsessive-compulsive and related disorders
Available categories by substance class
6C45.72
Cocaine-induced obsessive-compulsive or related disorder
6C46.72
Stimulant-induced obsessive-compulsive or related disorder, including
amfetamines, methamfetamine and methcathinone
6C47.72
Synthetic cathinone-induced obsessive-compulsive or related disorder
6C4E.72
Obsessive-compulsive or related disorder induced by other specified
psychoactive substance
6C4F.72
Obsessive-compulsive or related disorder induced by multiple specified
psychoactive substances
6C4G.72
Obsessive-compulsive or related disorder induced by unknown or unspecified
psychoactive substances
Essential (required) features
• The presentation is characterized by symptoms that share primary clinical features with
obsessive-compulsive and related disorders (e.g. obsessions, intrusive thoughts and
preoccupations, compulsions, recurrent and habitual actions directed at the integument).
• The obsessive-compulsive or related symptoms develop during or soon after intoxication
with or withdrawal from a specified substance, or use or discontinuation of a
psychoactive medication.
• The intensity or duration of the repetitive preoccupations and behaviours is substantially
in excess of analogous disturbances that are characteristic of intoxication or withdrawal
due to the specified substance.
• The specified substance, as well as the amount and duration of its use, is known to be
capable of producing obsessive-compulsive or related symptoms (see the list above and
Table 6.14, p. 454).
• The symptoms and behaviours are not better accounted for by another mental disorder –
in particular an obsessive-compulsive or related disorder. Evidence supporting a diagnosis
of another mental disorder would include obsessive-compulsive or related symptoms
preceding the onset of the substance use, the symptoms persisting for a substantial period
of time after cessation of the substance or medication use or withdrawal (e.g. 1 month or
Substance-induced obsessive-compulsive and related disorders

154 - Substance induced impulse control disorders
Substance-induced impulse control disorders
495
Disorders due to substance use or addictive behaviours
more depending on the specific substance), or other evidence of a pre-existing mental
disorder with obsessive-compulsive or related symptoms (e.g. a history of prior episodes
not associated with substance use).
• The symptoms and behaviours are not a manifestation of another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. If functioning is
maintained, it is only through significant additional effort.
Substance-induced impulse control disorders
Available categories by substance class
6C45.73
Cocaine-induced impulse control disorder
6C46.73
Stimulant-induced impulse control disorder, including amfetamines,
methamfetamine and methcathinone
6C47.73
Synthetic cathinone-induced impulse control disorder
6C4E.73
Impulse control disorder induced by other specified psychoactive substance
6C4F.73
Impulse control disorder induced by multiple specified psychoactive
substances
6C4G.73
Impulse control disorder induced by unknown or unspecified psychoactive
substances
Essential (required) features
• The presentation is characterized by persistently repeated behaviours in which there is
recurrent failure to resist an impulse, drive or urge to perform an act that is rewarding to
the person – at least in the short term – despite longer-term harm either to the individual or
to others (e.g. fire setting or stealing without apparent motive, repetitive sexual behaviour,
aggressive outbursts), or by behaviours similar to those seen in disorders due to addictive
behaviours (i.e. excessive gambling or gaming).
• The disturbance in impulse control develops during or soon after intoxication with or
withdrawal from a specified substance, or use or discontinuation of a psychoactive
medication.
• The intensity or duration of the disturbance in impulse control is substantially in excess of
impulse control disturbances that are characteristic of intoxication or withdrawal due to
the specified substance.
• The specified substance, as well as the amount and duration of its use, is known to be capable
of producing disturbances in impulse control (see the list above and Table 6.14, p. 454).
• The symptoms and behaviours are not better accounted for by another mental disorder
such as an impulse control disorder or a disorder due to addictive behaviours. Evidence
supporting a diagnosis of another mental disorder would include an impulse control
disturbance preceding the onset of the substance use, the disturbance persisting for a
substantial period of time after cessation of the substance or medication use or withdrawal
(e.g. 1 month or more depending on the specific substance), or other evidence of a preSubstance-induced impulse control disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
existing mental disorder with impulse control disturbance (e.g. a history of prior episodes
not associated with substance use).
• The symptoms and behaviours are not a manifestation of another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. If functioning is
maintained, it is only through significant additional effort.
Additional clinical features for substance-induced mental disorders
• Substance-induced mental disorders may present with varying patterns of symptoms,
depending on the specific substance used as well as characteristics of the user (e.g. genetics,
metabolism, personality factors). Substance use in higher amounts or over longer periods
of time is more likely to be associated with the development of a substance-induced
mental disorder.
• Symptoms of substance-induced mental disorder usually resolve or improve after sustained
cessation of substance use. Longer-lasting and in some cases permanent changes can
occur in amnestic disorder due to psychoactive substances, including medications, and in
dementia due to psychoactive substances, including medications. Perceptual disturbances
that last for weeks, months or years (e.g. trails of images of moving objects, geometric
illusions) can also occur as a result of hallucinogen use – primarily LSD – and are referred
to as “posthallucinogen perception disorder” or “hallucinogen-induced persisting
perception disorder”.
• The duration of substance withdrawal for some substances can be protracted. For
substances with more protracted withdrawal periods, the onset of symptoms of substanceinduced mental disorder can occur up to several weeks after the cessation of substance use.
Substance-induced mental disorder symptoms related to substances with more protracted
withdrawal periods may also last for correspondingly longer periods of time.
• In cases in which multiple psychoactive substances are used, it is often challenging to
distinguish which substance is the cause of the substance-induced mental disorder. When
the specific etiological substance cannot be determined, a diagnosis of substance-induced
mental disorder due to multiple specified psychoactive substances, including medications,
may assigned. In cases of multiple psychoactive substance use in which more than one
specific substance can be identified as a cause of the substance-induced mental disorder,
the corresponding specific substance-induced mental disorder diagnoses should be
given instead.
Boundary with normality (threshold) for substance-induced
mental disorders
• Symptoms of substance-induced mental disorders should be differentiated from known
side-effects of psychoactive medication that are not significantly impairing or distressing,
and from transient physiological aftereffects of intoxication (“hangover effects”). The
duration or severity of the symptoms in substance-induced mental disorders must be
Substance-induced impulse control disorders
497
Disorders due to substance use or addictive behaviours
in excess of side-effects (e.g. transient jitteriness as a side-effect of methylphenidate) or
hangover effects (e.g. transient low mood following alcohol use) of the specified substance,
and result in significant distress or impairment of functioning.
Boundaries with other disorders and conditions (differential
diagnosis) for substance-induced mental disorders
Boundary with substance intoxication and substance withdrawal
Mental or behavioural symptoms that occur during substance intoxication or substance
withdrawal should only be used as a basis for diagnosing a substance-induced mental disorder if
the intensity or duration of the symptoms is substantially in excess of those that are characteristic
of substance intoxication or substance withdrawal due to the specified substance (see Table 6.16,
p. 484), and the symptoms are sufficiently severe to warrant specific clinical attention.
Boundary with episode of harmful psychoactive substance use, harmful pattern of
psychoactive substance use or substance dependence
The impact of repeated or continuous use of substances characteristic of harmful pattern of
substance use and substance dependence may include substance-induced mental disorders.
Substance-induced mental disorders can also be associated with a single episode of substance use.
In such cases, a substance-induced mental disorder should be diagnosed together with a primary
diagnosis of episode of harmful psychoactive substance use, harmful pattern of psychoactive
substance use or substance dependence.
Boundary with mental disorders not induced by substances
Substance-induced mental disorders are differentiated from mental disorders with similar
features that are not induced by substances on the basis of their onset, course and clinical features.
A diagnosis of substance-induced mental disorder requires evidence from history, physical or
mental examination, or laboratory findings of recent substance use, intoxication or withdrawal.
Most substance-induced mental disorders resolve or improve within several weeks of cessation of
substance use. Mental disorders not induced by substances may precede the onset of substance use
or may continue to be symptomatic during periods of sustained abstinence. The co-occurrence
of substance use or withdrawal and onset of symptoms of mental disorders should not be taken
as evidence for a presumptive diagnosis of a substance-induced mental disorder. Some people
use substances to suppress symptoms of mental disorders (e.g. schizophrenia and other primary
psychotic disorders, mood disorders, anxiety and fear-related disorders, personality disorders),
and full symptomatic presentations only emerge upon cessation or reduction in substance use.
Furthermore, substance use can exacerbate symptoms or precipitate an episode of a pre-existing
mental disorder. Finally, substance use may be associated with – but not etiological for – new
onset of symptoms of a mental disorder. Although a diagnosis of a substance-induced mental
disorder should not be assigned under these circumstances, an additional diagnosis of episode of
harmful psychoactive substance use, harmful pattern of psychoactive substance use or substance
dependence may still be appropriate.
Substance-induced impulse control disorders

155 - Substance induced mental disorders listed in
Substance-induced mental disorders listed in other groupings

156 - Other specified disorder due to psychoactive
Other specified disorder due to psychoactive substance use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Substance-induced mental disorders listed in other groupings
The following categories are included in other mental disorder groupings, and CDDR are provided
in those sections, but they are cross-listed here for reference.
The following category is included in the ICD-11 grouping of catatonia:
Substance-induced catatonia
• 6A41 Catatonia induced by substances or medications (p. 204)
The following categories are included in the ICD-11 grouping of neurocognitive disorders:
Substance-induced amnestic disorder
• 6D72.1 Amnestic disorder due to psychoactive substances, including medications (p. 616)
• 6D72.10 Amnestic disorder due to use of alcohol
• 6D72.11 Amnestic disorder due to use of sedatives, hypnotics or anxiolytics
• 6D72.12 Amnestic disorder due to other specified psychoactive substance, including
medications
• 6D72.13 Amnestic disorder due to use of volatile inhalants
Note: the order of the categories above is different from that of other parallel entities (e.g. substanceinduced dementia, below), in which the “other specified” category is listed last. This difference is
not meaningful; the categories should be used in the same way.
Substance-induced dementia
• 6D84 Dementia due to psychoactive substances, including medications (p. 626)
• 6D84.0 Dementia due to use of alcohol
• 6D84.1 Dementia due to use of sedatives, hypnotics or anxiolytics
• 6D84.2 Dementia due to use of volatile inhalants
• 6D84.Y Dementia due to other specified psychoactive substance
Other specified disorder due to psychoactive substance use
Available categories by substance class
6C40.Y
Other specified disorder due to use of alcohol
6C41.Y
Other specified disorder due to use of cannabis
6C42.Y
Other specified disorder due to use of synthetic cannabinoids
6C43.Y
Other specified disorder due to use of opioids
6C44.Y
Other specified disorder due to use of sedatives, hypnotics or anxiolytics
6C45.Y
Other specified disorder due to use of cocaine
6C46.Y
Other specified disorder due to use of stimulants, including amfetamines,
methamfetamine and methcathinone
6C47.Y
Other specified disorder due to use of synthetic cathinones
Substance-induced mental disorders listed in other groupings

157 - Disorders due to psychoactive substance use,
Disorders due to psychoactive substance use, unspecified
499
Disorders due to substance use or addictive behaviours
6C48.Y
Other specified disorder due to use of caffeine
6C49.Y
Other specified disorder due to use of hallucinogens
6C4A.Y
Other specified disorder due to use of nicotine
6C4B.Y
Other specified disorder due to use of volatile inhalants
6C4C.Y
Other specified disorder due to use of MDMA or related drugs, including
MDA
6C4D.Y
Other specified disorder due to use of dissociative drugs, including ketamine
and PCP
6C4E.Y
Other specified disorder due to use of other specified psychoactive substance,
including medications
6C4F.Y
Other specified disorder due to use of multiple specified psychoactive
substances
6C4G.Y
Other specified disorder due to use of unknown or unspecified psychoactive
substances
Essential (required) features
• The presentation is characterized by psychological, cognitive or behavioural symptoms that
develop during or soon after intoxication with or withdrawal from a specified substance,
or use or discontinuation of a psychoactive medication.
• The symptoms do not fulfil the diagnostic requirements for any other disorder in the
disorders due to substance use grouping.
• The intensity or duration of the symptoms is substantially in excess of disturbances that are
characteristic of intoxication or withdrawal due to the specified substance.
• The symptoms are not better accounted for by another mental disorder such as
schizophrenia or another primary psychotic disorder, or a mood disorder. Evidence
supporting a diagnosis of another mental disorder would include the symptoms preceding
the onset of the substance use, the symptoms persisting for a substantial period of time
after cessation of the substance or medication use or withdrawal (e.g. 1 month or more
depending on the specific substance), or other evidence of a pre-existing mental disorder
(e.g. a prior history of the symptoms not associated with substance use).
• The symptoms are not a manifestation of another medical condition.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. If functioning is
maintained, it is only through significant additional effort.
Disorders due to psychoactive substance use, unspecified
Available categories by substance class
6C40.Z
Disorder due to use of alcohol, unspecified
6C41.Z
Disorder due to use of cannabis, unspecified
6C42.Z
Disorder due to use of synthetic cannabinoids, unspecified
6C43.Z
Disorder due to use of opioids, unspecified
Substance-induced impulse control disorders

158 - 6C4H Disorders due to use of non psychoactive
6C4H Disorders due to use of non-psychoactive substances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C44.Z
Disorder due to use of sedatives, hypnotics or anxiolytics, unspecified
6C45.Z
Disorder due to use of cocaine, unspecified
6C46.Z
Disorder due to use of stimulants, including amfetamines, methamfetamine
and methcathinone, unspecified
6C47.Z
Disorder due to use of synthetic cathinones, unspecified
6C48.Z
Disorder due to use of caffeine, unspecified
6C49.Z
Disorder due to use of hallucinogens, unspecified
6C4A.Z
Disorder due to use of nicotine, unspecified
6C4B.Z
Disorder due to use of volatile inhalants, unspecified
6C4C.Z
Disorder due to use of MDMA or related drugs, including MDA, unspecified
6C4D.Z
Disorder due to use of dissociative drugs, including ketamine and PCP,
unspecified
6C4E.Z
Disorder due to use of other specified psychoactive substance, including
medications, unspecified
6C4F.Z
Disorder due to use of multiple specified psychoactive substances, unspecified
6C4G.Z
Disorder due to use of unknown or unspecified psychoactive substances,
unspecified
Disorders due to use of non-psychoactive substances
Disorders due to use of non-psychoactive substances are characterized by the pattern and
consequences of non-psychoactive substance use. Non-psychoactive substances include laxatives,
growth hormone, erythropoietin and non-steroidal anti-inflammatory drugs. They may also
include proprietary or over-the-counter medicines and folk remedies.
Disorders due to use of non-psychoactive substances do not include disorders related
to psychoactive substances such as anabolic steroids, antidepressants, medications with
anticholinergic properties (e.g. benztropine), and some antihistamines. These should be classified
under 6C4E Disorders due to use of other specified psychoactive substance, including medications.
Episode of harmful use of non-psychoactive substances
Essential (required) features
• An episode of use of a non-psychoactive substance that has caused clinically significant
damage to a person’s physical health or mental health is required for diagnosis.
• Harm to the health of the individual occurs due to the direct or secondary toxic effects
of the non-psychoactive substance on body organs and systems, or a harmful route of
administration.
• The harm to health is not better accounted for by a medical condition not caused by the
substance or by another mental disorder.
6C4H
Substance-induced mental disorders | Disorders due to use of non-psychoactive substances
6C4H.0
501
Disorders due to substance use or addictive behaviours
Note: harm to physical health includes acute health problems resulting from non-psychoactive
substance use such as dehydration or dyslipidemia, and exacerbation or decompensation of
pre-existing chronic health problems such as hypertension, liver disease or peptic ulceration.
Harm may also result from a harmful route of administration (e.g. non-sterile intravenous selfadministration causing infections). Harm to mental health refers to psychological and behavioural
symptoms following non-psychoactive substance use (e.g. severe depressive symptoms following
dehydration and mineral loss from inappropriate use of laxatives).
Additional clinical features
• There must be explicit evidence of harm to the individual’s physical or mental health.
There must also be a clear causal relationship between the harm to health and the episode
of non-psychoactive substance use in question.
• Non-psychoactive substance use may occur in the context of other mental disorders (e.g.
use of laxatives in anorexia nervosa to reduce body weight, use of anabolic steroids in
body dysmorphic disorder to increase muscle mass). An additional diagnosis of episode
of harmful psychoactive substance use can be made if the specific episode of nonpsychoactive substance use in question has resulted in clinically significant harm to the
individual’s physical or mental health.
• A diagnosis of episode of harmful use of non-psychoactive substances often signals
an opportunity for intervention, including lower-intensity interventions that can be
implemented in a wide range of settings aimed at reducing the likelihood of additional
harmful episodes, or of progression to harmful pattern of non-psychoactive substance use.
• As more information becomes available indicating that an episode is part of a continuous
or recurrent pattern of harmful non-psychoactive substance use, a diagnosis of episode
of harmful psychoactive substance use should be changed to harmful pattern of nonpsychoactive substance use.
Boundary with normality (threshold)
• The diagnosis of episode of harmful use of non-psychoactive substances requires clinically
significant harm to the individual’s physical or mental health. Examples of impact on
physical or mental health that would not be considered clinically significant include mild
hangover, brief episodes of vomiting or transient depressed mood.
• An episode of non-psychoactive substance use may also cause social problems that do not
constitute clinically significant harm to physical or mental health (e.g. arguments with
loved ones). A diagnosis of episode of harmful use of non-psychoactive substances should
not be assigned in these circumstances.
Substance-induced mental disorders | Disorders due to use of non-psychoactive substances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with other specified hazardous drug use
The category other specified hazardous drug use from Chapter 24 on factors influencing health
status or contact with health services may be assigned if the episode of non-psychoactive substance
use in question appreciably increases the risk of harmful physical or mental health consequences
to an extent that warrants attention and advice from health professionals, but has not resulted in
specific identifiable harm to the individual’s physical or mental health.
Boundary with harmful pattern of non-psychoactive substance use
If the harm to health is a result of a known episodic or continuous pattern of non-psychoactive
substance use, harmful pattern of non-psychoactive substance use is the appropriate diagnosis
rather than episode of harmful use of non-psychoactive substances. Substance use is generally
considered to be following a pattern if there has been at least episodic or intermittent use over
a period of at least 12 months, or continuous use over at least 1 month. If harm is caused by
use of a non-psychoactive substance but no information is available about the pattern or history
of substance use, a diagnosis of episode of harmful use of non-psychoactive substances may be
assigned until such time as evidence for a pattern of use is ascertained.
Boundary with injury, poisoning or certain other consequences of external causes
When use of a non-psychoactive substance results in injury or life-threatening symptoms (e.g.
coma, severe cardiac, respiratory symptoms), a diagnosis from the grouping of harmful effects of
substances in Chapter 22 on injury, poisoning or certain other consequences of external causes
should also be assigned.
Harmful pattern of use of non-psychoactive substances
Essential (required) features
• A pattern of repeated or continuous use of a non-psychoactive substance that has caused
clinically significant damage to a person’s physical health or mental health is required for
diagnosis.
• Harm to the health of the individual occurs due to the direct or secondary toxic effects
of the non-psychoactive substance on body organs and systems, or a harmful route of
administration.
• The pattern of use of the relevant substance is evident over a period of at least 12 months if
substance use is episodic or at least 1 month if use is continuous.
• The harm to health is not better accounted for by a medical condition not caused by the
substance or by another mental disorder.
Note: harm to physical health includes acute or chronic health problems resulting from a pattern
of non-psychoactive substance use such as testicular atrophy, cardiomegaly, and exacerbation
6C4H.1
Substance-induced mental disorders | Disorders due to use of non-psychoactive substances
503
Disorders due to substance use or addictive behaviours
or decompensation of pre-existing chronic health problems such as hypertension, liver disease
or peptic ulceration. Harm may also result from a harmful route of administration (e.g. nonsterile intravenous self-administration causing infections). Harm to mental health refers to
psychological and behavioural symptoms following non-psychoactive substance use (e.g. severe
depressive symptoms due to dehydration and mineral loss from inappropriate use of laxatives).
Course specifiers
Harmful pattern of use of non-psychoactive substances, episodic
This category is assigned when all the diagnostic requirements for harmful pattern of use of
non-psychoactive substances are met, and there is evidence of a pattern of recurrent episodic or
intermittent use of the relevant non-psychoactive substance over a period of at least 12 months
that has caused clinically significant harm to a person’s physical or mental health.
Harmful pattern of use of non-psychoactive substances, continuous
This category is assigned when all the diagnostic requirements for harmful pattern of use of nonpsychoactive substances are met, and there is evidence of a pattern of continuous substance use
(daily or almost daily) of the relevant non-psychoactive substance over a period of at least 1
month that has caused clinically significant harm to a person’s physical or mental health.
Harmful pattern of use of non-psychoactive substances, unspecified
Additional clinical features for harmful pattern of use of nonpsychoactive substances
• There must be explicit evidence of harm to the individual’s physical or mental health.
There must also be a clear causal relationship between the harm to health and the episode
of non-psychoactive substance use in question.
• Non-psychoactive substance use may occur in the context of other mental disorders (e.g.
use of laxatives in anorexia nervosa to reduce body weight, use of anabolic steroids in
body dysmorphic disorder to increase muscle mass). An additional diagnosis of harmful
pattern of non-psychoactive substance use can be made if the pattern of non-psychoactive
substance use has resulted in clinically significant harm to the individual’s physical or
mental health.
6C4H.10
6C4H.11
Substance-induced mental disorders | Disorders due to use of non-psychoactive substances
6C4H.1Z

159 - 6C4Z Disorders due to substance use, unspecif
6C4Z Disorders due to substance use, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• The diagnosis of harmful pattern of use of non-psychoactive substances requires clinically
significant harm to the individual’s physical or mental health. Examples of impact on
physical or mental health that would not be considered clinically significant include mild
hangover, brief episodes of vomiting or transient depressed mood.
• A pattern of non-psychoactive substance use may also cause social problems that do not
constitute clinically significant harm to physical or mental health (e.g. arguments with
loved ones). A diagnosis of harmful pattern of use of non-psychoactive substances should
not be assigned in these circumstances.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with episode of harmful non-psychoactive substance use
If the harm to health is a result of a single episode of non-psychoactive substance use rather than
an episodic or continuous pattern of substance use, episode of harmful use of non-psychoactive
substances is the appropriate diagnosis rather than harmful pattern of non-psychoactive
substance use. Substance use is generally considered to be following a pattern if there has been
at least episodic or intermittent use over a period of at least 12 months, or continuous use over
at least 1 month. If harm is caused by use of a non-psychoactive substance but no information is
available about the pattern or history of substance use, a diagnosis of episode of harmful use of
non-psychoactive substances may be assigned until such time as evidence for a pattern of use is
ascertained.
Boundary with injury, poisoning or certain other consequences of external causes
When use of a non-psychoactive substance results in injury or life-threatening symptoms (e.g.
coma, severe cardiac or respiratory symptoms), a diagnosis from the grouping of harmful effects
of substances in Chapter 22 on injury, poisoning or certain other consequences of external causes
should also be assigned.
Disorders due to substance use, unspecified
6C4Z
Substance-induced mental disorders | Disorders due to use of non-psychoactive substances

16 - Schizophrenia and other primary psychotic dis
Schizophrenia and other primary psychotic disorders
161
Schizophrenia and other primary psychotic disorders
Schizophrenia and other primary psychotic disorders include
the following:
Schizophrenia and other primary psychotic disorders is a grouping of disorders characterized by
significant impairments in reality testing, and alterations in behaviour as manifested in symptoms
such as delusions, hallucinations, formal thought disorder (typically manifested as disorganized
speech) and disorganized behaviour. They may be accompanied by psychomotor disturbances
and negative symptoms such as blunted or flat affect. These symptoms do not occur primarily
as a result of substance use (e.g. hallucinogen intoxication) or another medical condition not
classified under mental, behavioural and neurodevelopmental disorders (e.g. Huntington
disease). The disorders in this grouping are referred to as “primary psychotic disorders” because
psychotic symptoms are their defining feature. Psychotic symptoms may also occur in the context
of other mental disorders (e.g. in mood disorders or dementia), but in these cases the symptoms
occur alongside other characteristic features of those disorders. Whereas experiences of reality
loss/distortion occur on a continuum and can be found throughout the population, disorders in
this group represent patterns of symptoms and behaviours that occur with sufficient frequency
and intensity to deviate from expected cultural or subcultural expectations.
6A23
Acute and transient psychotic disorder
6A24
Delusional disorder
6A2Y
Other specified primary psychotic disorder
6A2Z
Schizophrenia or other primary psychotic disorder,
unspecified.
6A21
Schizoaffective disorder
6A22
Schizotypal disorder
Schizophrenia and other
primary psychotic disorders
6A20
Schizophrenia
In the context of schizotypal disorder, symptoms may be substantially attenuated such that they
may be characterized as eccentric or peculiar rather than overtly psychotic.
The categories in the grouping of schizophrenia and other primary psychotic disorders should
not be used to classify the expression of ideas, beliefs or behaviours that are culturally sanctioned.
Many religious or cultural practices worldwide incorporate experiences qualitatively similar
in nature to the symptoms described for this grouping of disorders, and these should not be
considered to be pathological.
Schizophrenia and other primary psychotic disorders

160 - Hazardous substance use
Hazardous substance use

161 - QE10 Hazardous alcohol use
QE10 Hazardous alcohol use

162 - QE11 Hazardous drug use
QE11 Hazardous drug use
505
Disorders due to substance use or addictive behaviours
Secondary-parented categories in disorders due to substance use
Hazardous substance use
ICD-11 also includes a listing of hazardous substance use categories. These are not considered
to be mental disorders but rather are included in the grouping “Problems associated with health
behaviours” in Chapter 24 on factors influencing health status or contact with health services.
Available categories for hazardous substance use due to specific substance classes are as follows.
Hazardous substance use categories may be used when the pattern of substance use appreciably
increases the risk of harmful physical or mental health consequences, to the user or to others, to
an extent that warrants attention and advice from health professionals, but no overt harm has yet
occurred.
In hazardous substance use, the increased risk may be related to the frequency of substance use,
to the amount used on a given occasion, or to risky behaviours associated with substance use
or the context of use, from a harmful route of administration, or from a combination of these.
The risk may be related to short-term effects of the substance or to longer-term cumulative effects
on physical or mental health or functioning. Hazardous substance use has not yet reached the
level of having caused harm to physical or mental health of the user or others around the user.
The pattern of substance use often persists in spite of awareness of increased risk of harm to the
user or to others.
Hazardous alcohol use
Hazardous drug use
QE11.0 Hazardous use of opioids
QE11.1 Hazardous use of cannabis
QE11.2 Hazardous use of sedatives, hypnotics or anxiolytics
QE11.3 Hazardous use of cocaine
QE11.4 Hazardous use of stimulants, including amfetamines, methamfetamine and methcathinone
QE11.5 Hazardous use of caffeine
QE11.6 Hazardous use of MDMA or related drugs
QE11.7 Hazardous use of dissociative drugs, including ketamine and PCP
QE11.8 Hazardous use of other specified psychoactive substance
QE11.9 Hazardous use of unknown or unspecified psychoactive substances
QE11.Y Other specified hazardous drug use
QE11.Z Hazardous drug use, unspecified
QE10
QE11
Hazardous substance use

163 - QE12 Hazardous nicotine use
QE12 Hazardous nicotine use

164 - Disorders due to addictive behaviours
Disorders due to addictive behaviours
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Hazardous nicotine use
Disorders due to addictive behaviours
Disorders due to addictive behaviours are recognizable and clinically significant syndromes
associated with distress or interference with personal functions that develop as a result of
repetitive, rewarding behaviours other than the use of dependence-producing substances or
sexual behaviours.
Disorders due to addictive behaviours
QE12
6C50
Gambling disorder
6C50.0 Gambling disorder, predominantly offline
6C50.1 Gambling disorder, predominantly online
6C50.Z Gambling disorder, unspecified
Also listed in this section are two categories that are not considered to be mental disorders but
may be used when the pattern of the relevant behaviour appreciably increases the risk of harmful
physical or mental health consequences, to the individual or to others around this individual,
to an extent that warrants attention and advice from health professionals but does not meet the
diagnostic requirements for gambling disorder or gaming disorder.
Also listed in this section are two categories that are not considered to be mental disorders but
may be used when the pattern of the relevant behaviour appreciably increases the risk of harmful
physical or mental health consequences, to the individual or to others around this individual,
to an extent that warrants attention and advice from health professionals but does not meet the
diagnostic requirements for gambling disorder or gaming disorder.
6C51
Gaming disorder
6C51.0 Gaming disorder, predominantly online
6C51.1 Gaming disorder, predominantly offline
6C51.Z Gaming disorder, unspecified
6C5Y
Other specified disorder due to addictive behaviours
6C5Z
Disorder due to addictive behaviours, unspecified.
QE21
Hazardous gambling or betting
QE22
Hazardous gaming
Disorders due to addictive behaviours include the following:

165 - 6C50 Gambling disorder
6C50 Gambling disorder
507
Disorders due to substance use or addictive behaviours
Gambling disorder
Essential (required) features
• A persistent pattern of gambling behaviour – which may be predominantly online (i.e.
over the internet or similar electronic networks) or offline – is required for diagnosis,
manifested in all of the following:
• impaired control over gambling behaviour (e.g. onset, frequency, intensity, duration,
termination, context);
• increasing priority given to gambling behaviour to the extent that gambling takes
precedence over other life interests and daily activities;
• continuation or escalation of gambling behaviour despite negative consequences (e.g.
marital conflict due to gambling behaviour, repeated and substantial financial losses,
negative impact on health).
• The pattern of gambling behaviour may be continuous or episodic and recurrent, but is
manifested over an extended period of time (e.g. 12 months).
• The gambling behaviour is not better accounted for by another mental disorder (e.g. a
manic episode) and is not due to the effects of a substance or medication.
• The pattern of gambling behaviour results in significant distress or impairment in personal,
family, social, educational, occupational or other important areas of functioning.
Specifiers for online or offline behaviour
Note: the order of specifiers is different than for 6C51 Gaming disorder.
Gambling disorder, predominantly offline
• This refers to gambling disorder that predominantly involves gambling behaviour that is
not conducted over the internet or similar electronic networks (i.e. offline).
Gambling disorder, predominantly online
• This refers to gambling disorder that predominantly involves gambling behaviour that is
conducted over the internet or similar electronic networks (i.e. online).
Gambling disorder, unspecified
6C50
6C50.0
6C50.1
6C50.Z
Disorders due to addictive behaviours | Gambling disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• If symptoms and consequences of gambling behaviour are severe (e.g. gambling behaviours
persist for days at a time without respite, or have major effects on functioning or health)
and all other diagnostic requirements are met, it may be appropriate to assign a diagnosis
of gambling disorder following a period that is briefer than 12 months (e.g. 6 months).
• Individuals with gambling disorder may make numerous unsuccessful efforts to control
or significantly reduce gambling behaviour, whether self-initiated or imposed by others.
• Individuals with gambling disorder may increase the amount of money gambled over time
to maintain or exceed previous levels of excitement, or to avoid boredom. They may also
engage in a pattern of increasing intensity of gambling behaviour, increasing the amount of
their wagers, or otherwise altering their gambling strategies in order to try to compensate
for significant monetary loses (“chasing” their losses).
• Individuals with gambling disorder often experience urges or cravings to engage in
gambling behaviour during other activities.
• Individuals with gambling disorder may exhibit substantial disruptions in diet, sleep,
exercise and other health-related behaviours that can result in negative physical and
mental health outcomes.
• Some individuals with gambling disorder may engage in deceitful behaviour to conceal
the extent of their losses from loved ones, or attempt to obtain money in order to repay
their debts.
• Some individuals with gambling disorder may engage in gambling behaviour in response
to feelings of depression, anxiety, boredom, loneliness or other negative affective states.
Although not diagnostically determinative, consideration of the relationship between
emotional and behavioural cues and gambling behaviour can inform treatment planning.
• Gambling disorder commonly co-occurs with disorders due to substance use, mood
disorders, anxiety and fear-related disorders, and personality disorder. Among individuals
seeking treatment for gambling disorder, suicidal ideation and suicide attempts are
common.
• In adults, gambling behaviour is associated with chronic medical conditions, obesity and
poorer subjective health status.
Boundary with normality (threshold)
• Gambling disorder should not be diagnosed merely on the basis of repeated or persistent
gambling (online or offline), such as in the context of social or professional gambling.
Typically, these forms of gambling are limited to discrete periods, with monetary losses
that are acceptable to the individual, and occur in the absence of the other characteristic
features of the disorder.
• Daily gambling behaviour (e.g. buying lottery tickets) as a part of a routine or the use
of gambling for purposes such as changing mood, alleviating boredom or facilitating
social interaction in the absence of the other required features is not a sufficient basis for
assigning a diagnosis of gambling disorder.
Disorders due to addictive behaviours | Gambling disorder
509
Disorders due to substance use or addictive behaviours
Course features
• The course of gambling disorder is variable, with recovery a common outcome even in the
absence of intervention, especially for adolescents and young adults. However, for many,
gambling disorder persists across the lifespan.
• Gambling behaviour can follow a continuous or episodic pattern. The intensity of gambling
behaviour often fluctuates in relation to stress, depressive symptoms and substance use.
• Gambling disorder tends to develop gradually over the course of years, as frequency of
gambling behaviour and monetary value of wagers increase.
Developmental presentations
• Gambling disorder typically has its onset in adolescence or young adulthood. Early onset
is associated with higher levels of impulsivity. Prevalence of gambling disorder among
adolescents tends to be higher than among adults.
• Onset of gambling disorder in older adulthood is uncommon.
Culture-related features
• Prevalence of gambling disorder varies by sociocultural background. For example,
community-based prevalence in the United States is lower among immigrants than among
United States-born individuals. Indigenous populations in several counties (e.g. Canada,
New Zealand and the United States) appear to have higher prevalence than other ethnic
groups, possibly due to greater financial hardship, the hope that gambling may help
advance social goals, and the location of casinos on tribal lands.
• Endorsement of specific symptoms of gambling disorder may also vary cross-culturally. For
example, among individuals with gambling problems in the United States, Asian Americans
may be less likely to describe being preoccupied with gambling, while Latin Americans
and African Americans may be more likely to describe attempts to reduce gambling.
Sex- and/or gender-related features
• Lifetime prevalence of gambling disorder is higher among males. In adulthood, the ratio of
men to women diagnosed with gambling disorder is approximately 2:1. This gap is wider
during adolescence (ratio of 4:1), which may reflect boys’ tendency to start gambling earlier.
Disorders due to addictive behaviours | Gambling disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Due to earlier onset, the course of gambling disorder is typically more protracted among
men. Men also appear more likely to recover without intervention than women. Although
onset among women tends to be later, symptoms often intensify more quickly. Women are
more likely to seek treatment sooner than men, though treatment-seeking is low (less than
10%) across both genders.
• Women with gambling disorder are more likely to have co-occurring mood disorders or
anxiety and fear-related disorders, whereas men are more likely to exhibit problems with
substance abuse and externalizing behaviours.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with hazardous gambling or betting
The category of hazardous gambling or betting from Chapter 24 on factors influencing health
status or contact with health services may be assigned to individuals who exhibit problematic
patterns of gambling without the other features of gambling disorder. Hazardous gambling or
betting refers to a pattern of gambling that appreciably increases the risk of harmful physical
or mental health consequences, to the individual or to others around the individual, that may
require intervention or monitoring but is not considered a disorder.
Boundary with gaming disorder
Unlike gambling disorder, gaming disorder does not involve the betting of money or other
valuables with the hope of obtaining something of greater value. If gaming behaviour is focused
on wagers (e.g. internet poker), gambling disorder is generally the more appropriate diagnosis.
Boundary with bipolar and related disorders
Increased goal-directed activity – including impaired ability to control gambling behaviour – can
occur during manic, mixed or hypomanic episodes. A diagnosis of gambling disorder should
only be assigned if there is evidence of a persistent pattern of gambling behaviour that meets all
diagnostic requirements for the disorder, and occurs outside of mood episodes. Some individuals
with gambling disorder may exhibit symptoms while gambling that appear similar to those
observed during manic episodes (e.g. euphoric mood and increased energy level). However, in
mood episodes, such symptoms are not limited to the gambling context.
Boundary with obsessive-compulsive disorder
Gambling behaviour can sometimes be described as “compulsive” by lay people and also by some
health professionals. Compulsions observed in obsessive-compulsive disorder are almost never
experienced as inherently pleasurable; they typically occur in response to intrusive, unwanted
and generally anxiety-provoking obsessions, which is not the case with gambling behaviour in
gambling disorder.
Boundary with personality disorder
Some individuals with personality disorder with prominent dissocial features or prominent
features of disinhibition may engage in problematic gambling behaviour. A diagnosis of gambling
disorder can be assigned together with a personality disorder diagnosis if the diagnostic
requirements for both are met.
Disorders due to addictive behaviours | Gambling disorder

166 - 6C51 Gaming disorder
6C51 Gaming disorder
511
Disorders due to substance use or addictive behaviours
Boundary with disorders due to substance use
Co-occurrence of gambling and substance use – particularly alcohol – is common. Intoxication
due to some substances, including alcohol, can cause disinhibition and impaired judgement,
which may exacerbate problematic gambling behaviour. A diagnosis of gambling disorder can
be assigned together with a disorder due to substance use diagnosis if the requirements for both
are met.
Boundary with the effects of psychoactive substances, including medications
Use of specific prescribed medications or illicit substances (e.g. dopamine agonists such as
pramipexole for Parkinson disease or restless legs syndrome or illicit substances such as
methamfetamine) can sometimes cause impaired control over gambling behaviour due to their
direct effects on the central nervous system, with onset corresponding to use of the substance or
medication. Gambling disorder should not be diagnosed in such cases.
Gaming disorder
Essential (required) features
• A persistent pattern of gaming behaviour (“digital gaming” or “video gaming”) – which
may be predominantly online (i.e. over the internet or similar electronic networks) or
offline – is required for diagnosis, manifested in all of the following:
• impaired control over gaming behaviour (e.g. onset, frequency, intensity, duration,
termination, context);
• increasing priority given to gaming behaviour to the extent that gaming takes precedence
over other life interests and daily activities;
• continuation or escalation of gaming behaviour despite negative consequences (e.g.
family conflict due to gaming behaviour, poor scholastic performance, negative impact
on health).
• The pattern of gaming behaviour may be continuous or episodic and recurrent, but is
manifested over an extended period of time (e.g. 12 months).
• The gaming behaviour is not better accounted for by another mental disorder (e.g. a manic
episode) and is not due to the effects of a substance or medication.
• The pattern of gaming behaviour results in significant distress or impairment in personal,
family, social, educational, occupational or other important areas of functioning.
Specifiers for online or offline behaviour
Note: the order of specifiers is different than for 6C50 Gambling disorder.
6C51
Disorders due to addictive behaviours | Gaming disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Gaming disorder, predominantly online
• This refers to gaming disorder that predominantly involves gaming behaviour that is
conducted over the internet or similar electronic networks (i.e. online).
Gaming disorder, predominantly offline
• This refers to gaming disorder that predominantly involves gaming behaviour that is not
conduced over the internet or similar electronic networks (i.e. offline).
Gaming disorder, unspecified
Additional clinical features
• If symptoms and consequences of gaming behaviour are severe (e.g. gaming behaviours
persist for days at a time without respite or have major effects on functioning or health)
and all other diagnostic requirements are met, it may be appropriate to assign a diagnosis
of gaming disorder following a period that is briefer than 12 months (e.g. 6 months).
• Individuals with gaming disorder may make numerous unsuccessful efforts to control or
significantly reduce gaming behaviour, whether self-initiated or imposed by others.
• Individuals with gaming disorder may increase the duration or frequency of gaming
behaviour over time, or experience a need to engage in games of increasing levels of
complexity or requiring increasing skills or strategy in an effort to maintain or exceed
previous levels of excitement, or to avoid boredom.
• Individuals with gaming disorder often experience urges or cravings to engage in gaming
during other activities.
• Upon cessation or reduction of gaming behaviour, often imposed by others, individuals
with gaming disorder may experience dysphoria and exhibit adversarial behaviour or
verbal or physical aggression.
• Individuals with gaming disorder may exhibit substantial disruptions in diet, sleep, exercise
and other health-related behaviours that can result in negative physical and mental health
outcomes, particularly if there are very extended periods of gaming.
• High-intensity gaming behaviour may occur as a part of online computer games that
involve coordination among multiple users to accomplish complex tasks. In these cases,
peer-group dynamics may contribute to the maintenance of intensive gaming behaviours.
Regardless of the social contributions to the behaviour, the diagnosis of gaming disorder
may still be applied if all diagnostic requirements are met.
• Gaming disorder commonly co-occurs with disorders due to substance use, mood
disorders, anxiety and fear-related disorders, attention deficit hyperactivity disorder,
obsessive-compulsive disorder and sleep-wake disorders.
6C51.0
6C51.1
6C51.Z
Disorders due to addictive behaviours | Gaming disorder
513
Disorders due to substance use or addictive behaviours
Boundary with normality (threshold)
• Gaming disorder should not be diagnosed merely on the basis of repeated or persistent
gaming (online or offline) in the absence of the other characteristic features of the disorder.
• Daily gaming behaviour as a part of a routine or the use of gaming for purposes such
as developing skills and proficiency in gaming, changing mood, alleviating boredom or
facilitating social interaction in the absence of the other required features is not a sufficient
basis for assigning a diagnosis of gaming disorder.
• High rates and long durations of gaming behaviour (online or offline) that occur more
commonly among specific age and social groups (e.g. adolescent males), and in particular
contexts such as during the holidays or as part of organized gaming activities for
entertainment in the absence of the other required features, are also not indicative of a
disorder. Cultural, subcultural and peer-group norms should be considered when making
a diagnosis.
Course features
• The course of gaming disorder is typically progressive, as the individual increasingly
prioritizes gaming at the expense of other activities.
• Individuals with both autism spectrum disorder and attention deficit hyperactivity exhibit
elevated rates of problematic gaming and gaming disorder. This appears to be related
to preferences for particular types of stimuli, and possibly also to the use of gaming to
regulate attention.
Developmental presentations
• Gaming disorder appears to be most prevalent among adolescent and young adult males
aged 12–20 years. Available data suggest that adults have lower prevalence rates.
• Among adolescents, gaming disorder has been associated with elevated levels of
externalizing (e.g. antisocial behaviour, anger control) and internalizing (e.g. emotional
distress, lower self-esteem) problems. Among adults, gaming disorder has been associated
with greater levels of depressive and anxiety symptoms.
• Adolescents with gaming disorder may be at increased risk of academic underachievement,
school failure/dropout, and psychosocial and sleep problems.
Disorders due to addictive behaviours | Gaming disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Males appear to be more frequently affected by gaming disorder during both adolescence
and adulthood.
• Although less frequently diagnosed with gaming disorder than adolescent boys, girls
who meet the diagnostic requirements may be at greater risk of developing emotional or
behavioural problems.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with hazardous gaming
The category of hazardous gaming from Chapter 24 on factors influencing health status or contact
with health services may be assigned to individuals who exhibit problematic patterns of gaming
behaviour without the other features of gaming disorder. Hazardous gaming refers to a pattern
of gaming that appreciably increases the risk of harmful physical or mental health consequences,
to the individual or to others around the individual, that may require some intervention or
monitoring but is not considered to constitute a disorder.
Boundary with gambling disorder
Unlike gaming disorder, gambling disorder necessitates the betting of money or other valuables
in the hope of obtaining something of greater value. If gaming behaviour is focused on wagers
(e.g. internet poker), gambling disorder may be a more appropriate diagnosis.
Boundary with bipolar and related disorders
Increased goal-directed activity – including impaired ability to control gaming behaviour – can
occur during manic, mixed or hypomanic episodes. A diagnosis of gaming disorder should
only be assigned if there is evidence of a persistent pattern of gaming behaviour that meets all
diagnostic requirements for the disorder, and occurs outside of mood episodes.
Boundary with obsessive-compulsive disorder
Gaming behaviour can sometimes be described as “compulsive” by lay people and also by some
health professionals. Compulsions observed in obsessive-compulsive disorder are almost never
experienced as inherently pleasurable; they typically occur in response to intrusive, unwanted
and generally anxiety-provoking obsessions, which is not the case with gaming behaviour in
gaming disorder.
Boundary with disorders due to substance use
Co-occurrence of gaming and substance use is common. Intoxication due to some substances
may exacerbate problematic gaming behaviour. A diagnosis of gaming disorder can be assigned
together with a disorder due to substance use diagnosis if the requirements for both are met.
Disorders due to addictive behaviours | Gaming disorder

167 - 6C5Y Other specified disorder due to addictiv
6C5Y Other specified disorder due to addictive behaviours

168 - 6C5Z Disorder due to addictive behaviours, un
6C5Z Disorder due to addictive behaviours, unspecified
515
Disorders due to substance use or addictive behaviours
Boundary with the effects of psychoactive substances, including medications
Use of specific prescribed medications or illicit substances (e.g. dopamine agonists such as
pramipexole for Parkinson disease or restless legs syndrome or illicit substances such as
methamfetamine) can sometimes cause impaired control over gaming behaviour due to their
direct effects on the central nervous system, with onset corresponding to use of the substance or
medication. Gaming disorder should not be diagnosed in such cases.
Other specified disorder due to addictive behaviours
Essential (required) features
• The presentation is characterized by symptoms that share primary clinical features with
other disorders due to addictive behaviours, including a persistent pattern of repetitive
behaviour in which the individual exhibits impaired control over the behaviour (e.g. onset,
frequency, intensity, duration, termination, context); increasing priority given to the
behaviour to the extent that it takes precedence over other life interests and daily activities;
and continuation or escalation of the behaviour despite negative consequences (e.g. family
conflict, poor scholastic performance, negative impact on health).
Note: impaired control over substance use or sexual behaviour is not included in
this category.
• The pattern of repetitive behaviour may be continuous or episodic and recurrent, but is
manifested over an extended period of time (e.g. 12 months).
• The symptoms are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. autism spectrum disorder, an obsessive-compulsive
or related disorder, a feeding or eating disorder, an impulse control disorder), are not a
manifestation of another medical condition, and are not due to the effects of a substance
or medication on the central nervous system, including withdrawal effects.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning.
Disorder due to addictive behaviours, unspecified
6C5Y
6C5Z
Disorders due to addictive behaviours | Other specified disorder due to addictive behaviour

169 - Hazardous gambling or betting and hazardous g
Hazardous gambling or betting and hazardous gaming

17 - 6A20 Schizophrenia
6A20 Schizophrenia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
General cultural considerations for schizophrenia and other primary
psychotic disorders
• Beliefs vary across cultures such that those considered odd or unusual in one culture may
be normative in another. For example, belief in witchcraft or supernatural forces, or fears
that transgressing cultural norms can lead to misfortune, are typical in many cultures.
Distress may be expressed in ways that may be misinterpreted as evidence of psychotic
symptoms, such as pseudo-hallucinations and overvalued ideas or dissociative experiences
related to trauma.
• In some cultures, distress due to social circumstances may be expressed in ways that can be
misinterpreted as psychotic symptoms (e.g. overvalued ideas and pseudo-hallucinations)
but that instead are considered normal for the person’s subgroup.
• Symptom presentation of schizophrenia and other primary psychotic disorders may
vary across cultures. For example, the content and form of hallucinations (e.g. visual
hallucinations are more common in some cultural groups and in some countries) or
delusions may be culturally derived, making it difficult to differentiate among culturally
normal experiences, overvalued ideas, ideas of reference and transient psychosis. For
instance, in several cultures (e.g. southern China, Latin America) it is common to expect
the spirit of a deceased relative to visit the homes of living relatives soon after they die.
Hearing, seeing or interacting with this spirit may be reported without notable pathological
sequelae. Clarifying the cultural meaning of these experiences can aid in understanding
the diagnostic significance of the symptom presentation.
• Cultural mismatch between the individual and the clinician may complicate the evaluation
of schizophrenia and other primary psychotic disorders. Collateral information from
family, community, religious or cultural reference groups may help clarify the diagnosis.
• Ethnic minority and migrant groups are more likely than those in the general population
to receive a diagnosis of schizophrenia and other primary psychotic disorder. This may be
due to misdiagnosis or to greater risk of psychosis resulting from migration traumas, social
isolation, minority and acculturative stress, discrimination and victimization.
• Caution is advised when assessing psychotic symptoms through interpreters or in a second
or third language because of the risk of misconstruing unfamiliar metaphors as delusions,
and natural defensiveness as paranoia or emotional blunting.
Schizophrenia
Essential (required) features
• At least two of the following symptoms must be present (by the individual’s report or
through observation by the clinician or other informants) most of the time for a period
of 1 month or more. At least one of the qualifying symptoms should be from items
a) to d) below:
a) persistent delusions (e.g. grandiose delusions, delusions of reference, persecutory
delusions);
b) persistent hallucinations (most commonly auditory, although they may be in any
sensory modality);
6A20
Schizophrenia and other primary psychotic disorders | Schizophrenia
163
Schizophrenia and other primary psychotic disorders
c) disorganized thinking (formal thought disorder) (e.g. tangentiality and loose
associations, irrelevant speech, neologisms) – when severe, the person’s speech may
be so incoherent as to be incomprehensible (“word salad”);
d) experiences of influence, passivity or control (i.e. the experience that one’s feelings,
impulses, actions or thoughts are not generated by oneself, are being placed in one’s
mind or withdrawn from one’s mind by others, or that one’s thoughts are being
broadcast to others);
e) negative symptoms such as affective flattening, alogia or paucity of speech, avolition,
asociality and anhedonia;
f) grossly disorganized behaviour that impedes goal-directed activity (e.g. behaviour
that appears bizarre or purposeless, unpredictable or inappropriate emotional
responses that interferes with the ability to organize behaviour);
g) psychomotor disturbances such as catatonic restlessness or agitation, posturing,
waxy flexibility, negativism, mutism or stupor. Note: if the full syndrome of catatonia
(p. 202) is present in the context of schizophrenia, the diagnosis of 6A40 Catatonia
associated with another mental disorder should also be assigned.
• The symptoms are not a manifestation of another medical condition (e.g. a brain tumour),
and are not due to the effects of a substance or medication (e.g. corticosteroids) on the central
nervous system, including withdrawal effects (e.g. from alcohol).
Course specifiers for schizophrenia
The following specifiers should be applied to identify the course of schizophrenia, including
whether the individual currently meets the diagnostic requirements of schizophrenia or is in
partial or full remission. Course specifiers are also used to indicate whether the current episode
is the first episode of schizophrenia, whether there have been multiple such episodes, or whether
symptoms have been continuous over an extended period of time.
Schizophrenia, first episode
• The first episode specifier should be applied when the current or most recent episode is the first
manifestation of schizophrenia meeting all diagnostic requirements in terms of symptoms
and duration. If there has been a previous episode of schizophrenia or schizoaffective disorder,
the multiple episodes specifier should be applied.
Schizophrenia, first episode, currently symptomatic
• All diagnostic requirements for schizophrenia in terms of symptoms and duration are
currently met, or have been met within the past month.
• There have been no previous episodes of schizophrenia or schizoaffective disorder.
Note: if the duration of the episode is more than 1 year, the continuous specifier may be used
instead, depending on the clinical situation.
6A20.00
6A20.0
Schizophrenia and other primary psychotic disorders | Schizophrenia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Schizophrenia, first episode, in partial remission
• The full diagnostic requirements for schizophrenia have not been met within the past
month, but some clinically significant symptoms remain, which may or may not be
associated with functional impairment.
• There have been no previous episodes of schizophrenia or schizoaffective disorder.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms
of schizophrenia following an asymptomatic period in a person who has previously met the
diagnostic requirements for schizophrenia.
Schizophrenia, first episode, in full remission
• The full diagnostic requirements for schizophrenia have not been met within the past
month, and no clinically significant symptoms remain.
• There have been no previous episodes of schizophrenia or schizoaffective disorder.
Schizophrenia, first episode, unspecified
Schizophrenia, multiple episodes
• The multiple episodes specifier should be applied when there have been a minimum of two
episodes meeting all diagnostic requirements of schizophrenia or schizoaffective disorder
in terms of symptoms, with a period of partial or full remission between episodes lasting
at least 3 months, and the current or most recent episode is schizophrenia. Note that the
1-month duration requirement for the first episode does not necessarily need to be met
for subsequent episodes. During the period of remission, the diagnostic requirements of
schizophrenia are either only partially fulfilled or absent.
Schizophrenia, multiple episodes, currently symptomatic
• All symptom requirements for schizophrenia are currently met, or have been met within
the past month. Note that the 1-month duration requirement for the first episode does not
necessarily need to be met for subsequent episodes.
• There have been a minimum of two episodes of schizophrenia or a previous episode of
schizoaffective disorder, with a period of partial or full remission between episodes lasting
at least 3 months.
Schizophrenia, multiple episodes, in partial remission
• The full diagnostic requirements for schizophrenia have not been met within the past
month, but some clinically significant symptoms remain, which may or may not be
associated with functional impairment.
6A20.01
6A20.02
6A20.0Z
6A20.1
6A20.10
6A20.11
Schizophrenia and other primary psychotic disorders | Schizophrenia
165
Schizophrenia and other primary psychotic disorders
• There have been a minimum of two episodes of schizophrenia or a previous episode of
schizoaffective disorder, with a period of partial or full remission between episodes lasting
at least 3 months.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms of
schizophrenia following an asymptomatic period.
Schizophrenia, multiple episodes, in full remission
• The full diagnostic requirements for schizophrenia have not been met within the past
month, and no clinically significant symptoms remain.
• There have been a minimum of two episodes of schizophrenia or a previous episode of
schizoaffective disorder, with a period of partial or full remission between episodes lasting
at least 3 months.
Schizophrenia, multiple episodes, unspecified
Schizophrenia, continuous
• The continuous specifier should be applied when symptoms fulfilling all diagnostic
requirements of schizophrenia have been present for almost all of the course of the disorder
during the person’s lifetime since its first onset, with periods of subthreshold symptoms
being very brief relative to the overall course. In order to apply this specifier to a first
episode, the duration of schizophrenia should be at least 1 year. In that case, the continuous
specifier should be applied instead of the first episode specifier.
Schizophrenia, continuous, currently symptomatic
• All symptom requirements for schizophrenia are currently met, or have been met within
the past month.
• Symptoms meeting the diagnostic requirements for schizophrenia have been present for
almost all of the course of the disorder during the person’s lifetime since its first onset.
• Periods of partial or full remission have been very brief relative to the overall course, and
none have lasted for 3 months or longer.
• To apply the continuous specifier to a first episode, symptoms meeting the diagnostic
requirements for schizophrenia must have been present for at least 1 year.
Schizophrenia, continuous, in partial remission
• The full diagnostic requirements for schizophrenia, continuous were previously met but
have not been met within the past month.
• Some clinically significant symptoms of schizophrenia remain, which may or may not be
associated with functional impairment.
6A20.12
6A20.1Z
6A20.2
6A20.20
6A20.21
Schizophrenia and other primary psychotic disorders | Schizophrenia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Note: this category may also be used to designate the re-emergence of subthreshold symptoms of
schizophrenia following an asymptomatic period.
Schizophrenia, continuous, in full remission
• The full diagnostic requirements for schizophrenia, continuous were previously met but have
not been met within the past month.
• No clinically significant symptoms of schizophrenia remain.
Schizophrenia, continuous, unspecified
Other specified episode of schizophrenia
Schizophrenia, episode unspecified
Additional clinical features
• The onset of schizophrenia may be acute, with serious disturbance apparent within a few
days, or insidious, with a gradual development of signs and symptoms.
• A prodromal phase often precedes the onset of psychotic symptoms by weeks or months.
The characteristic features of this phase often include loss of interest in work or social
activities, neglect of personal appearance or hygiene, inversion of the sleep cycle and
attenuated psychotic symptoms, accompanied by negative symptoms, anxiety/agitation or
varying degrees of depressive symptoms.
• Between acute episodes there may be residual phases, which are similar phenomenologically
to the prodromal phase.
• Schizophrenia is frequently associated with significant distress and significant impairment
in personal, family, social, educational, occupational or other important areas of
functioning. However, distress and psychosocial impairment are not requirements for a
diagnosis of schizophrenia.
Boundary with normality (threshold)
• Psychotic-like symptoms or unusual subjective experiences may occur in the general
population, but these are usually fleeting in nature and are not accompanied by other
6A20.22
6A20.2Z
6A20.Y
6A20.Z
Schizophrenia and other primary psychotic disorders | Schizophrenia
167
Schizophrenia and other primary psychotic disorders
symptoms of schizophrenia or a deterioration in psychosocial functioning. In schizophrenia,
multiple persistent symptoms are present, and are typically accompanied by impairment in
cognitive functioning and other psychosocial problems.
Course features
• The course and onset of schizophrenia is variable. Some experience exacerbations and
remission of symptoms periodically throughout their lives, others experience a gradual
worsening of symptoms, and a smaller proportion experience complete remission of
symptoms.
• Positive symptoms tend to diminish naturally over time, whereas negative symptoms often
persist and are closely tied to a poorer prognosis. Cognitive symptoms also tend to be more
persistent, and when present are associated with ongoing functional impairment.
• Early-onset schizophrenia is typically associated with a poorer prognosis whereas affective
and social functioning are more likely to be preserved with later onset.
Developmental presentations
• Onset of fully symptomatic schizophrenia before puberty is extremely rare; when it occurs
it is often preceded by a decline in social and academic functioning, odd behaviour,
and a change in affect observable during the prodromal phase. Childhood onset is also
associated with a greater prevalence of delays in social, language or motor development
and co-occurring disorder of intellectual development or developmental learning disorder.
• In children and young adolescents, auditory hallucinations most commonly occur
as a single voice commenting on or commanding behaviour whereas in adults such
hallucinations are more typically experienced as multiple conversing voices.
• In children and adolescents, it may be challenging to differentiate delusions and
hallucinations from more developmentally typical phenomena (e.g. a “monster” under
the child’s bed, an imaginary friend), actual plausible life experiences (e.g. being teased
or bullied at school), and irrational or magical thinking common in childhood (e.g. that
thinking about something will make it happen).
• Among children with schizophrenia, negative symptoms, hallucinations and disorganized
thinking – including loose associations, illogical thinking and paucity of speech – tend to
be prominent features of the clinical presentation. Disorganized thinking and behaviour
occur in a variety of disorders that are common in childhood (e.g. autism spectrum
disorder, attention deficit hyperactivity disorder), which should be considered before
attributing the symptoms to the much less common childhood schizophrenia.
Schizophrenia and other primary psychotic disorders | Schizophrenia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Culture-related features
• Cultural factors may influence the onset, symptom pattern, course and outcome
of schizophrenia. For example, among migrants and ethnic and cultural minority
communities, living in areas with a low proportion of their own migrant, ethnic or cultural
group (low “ethnic density”) is associated with higher rates of schizophrenia. In addition,
etiological or course-related factors may be affected by culture at the level of the family
(e.g. level of family support or style of family interaction, such as expressed emotion) or at
the societal context (e.g. industrialization, urbanization). For example, the prevalence of
schizophrenia is much higher in urban than rural settings.
• The risk of misdiagnosing the expression of distress as indicative of schizophrenia
or another primary psychotic disorder may be increased among ethnic minority and
immigrant groups, and in other situations in which the clinician is unfamiliar with
culturally normative expressions of distress. These include situations involving spiritual
or supernatural beliefs or resulting from migration trauma, social isolation, minority and
acculturative stress, discrimination and victimization.
Sex- and/or gender-related features
• Schizophrenia is more prevalent among males.
• The age of onset of the first psychotic episode differs by gender, with a greater proportion
of males experiencing onset in their early to mid-20s and females in their late 20s.
• Females with schizophrenia tend to report more positive symptoms that increase in severity
over the course of their lives. Females also tend to have greater mood disturbance and a
greater prevalence of subsequent or co-occurring mental disorders (e.g. schizoaffective
disorder, depressive disorders).
• Females with schizophrenia are less likely to exhibit disorganized thinking, negative
symptoms and social impairment.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizoaffective disorder
The diagnoses of schizophrenia and schizoaffective disorder are intended to apply to the current
or most recent episode of the disorder. In other words, a previous diagnosis of schizoaffective
disorder does not preclude a diagnosis of schizophrenia, and vice versa. In both schizophrenia and
schizoaffective disorder, at least two the characteristic symptoms of schizophrenia are present most of
the time for a period of 1 month or more. In schizoaffective disorder, the symptoms of schizophrenia
are present concurrently with mood symptoms that meet the full diagnostic requirements of a
mood episode and last for at least 1 month, and the onsets of the psychotic and mood symptoms
are either simultaneous or occur within a few days of one another. In schizophrenia, co-occurring
mood symptoms, if any, either do not persist for as long as 1 month or are not of sufficient severity
Schizophrenia and other primary psychotic disorders | Schizophrenia
169
Schizophrenia and other primary psychotic disorders
to meet the requirements of a moderate or severe depressive episode, a manic episode or a mixed
episode. (See mood episode descriptions, p. 212.) An episode that initially meets the diagnostic
requirements for schizoaffective disorder in which only the mood symptoms remit, so that the
duration of psychotic symptoms without mood symptoms is much longer than the duration of
concurrent symptoms, may be best characterized as an episode of schizophrenia.
Boundary with acute and transient psychotic disorder
The psychotic symptoms in schizophrenia persist for at least 1 month in their full, florid form.
In contrast, the symptoms in acute and transient psychotic disorder tend to fluctuate rapidly in
intensity and type across time, such that the content and focus of delusions or hallucinations often
shift, even on a daily basis. Such rapid shifts would be unusual in schizophrenia. Negative symptoms
are often present in schizophrenia, but do not occur in acute and transient psychotic disorder. The
duration of acute and transient psychotic disorder does not exceed 3 months, and most often lasts
from a few days to 1 month, compared to a much longer typical course for schizophrenia. In cases
that meet the diagnostic requirements for schizophrenia except that they have lasted less than the
duration required for a diagnosis (i.e. 1 month) in the absence of a previous history of schizophrenia,
a diagnosis of other specified primary psychotic disorder and not acute and transient psychotic
disorder should be assigned.
Boundary with schizotypal disorder
Schizotypal disorder is characterized by an enduring pattern of unusual speech, perceptions,
beliefs and behaviours that resemble attenuated forms of the defining symptoms of schizophrenia.
Schizophrenia is differentiated from schizotypal disorder based entirely on the intensity of
the symptoms: schizophrenia is diagnosed if the symptoms are sufficiently intense to meet
diagnostic requirements.
Boundary with delusional disorder
Both schizophrenia and delusional disorder may be characterized by persistent delusions. If
other features are present that meet the diagnostic requirements of schizophrenia (i.e. persistent
hallucinations; disorganized thinking; experiences of influence, passivity or control; negative
symptoms; disorganized or abnormal psychomotor behaviour), a diagnosis of schizophrenia
should be made instead of a diagnosis of delusional disorder. However, hallucinations that are
consistent with the content of the delusions and do not occur persistently (i.e. with regular
frequency for 1 month or longer) are consistent with a diagnosis of delusional disorder rather than
schizophrenia. Delusional disorder is generally characterized by relatively preserved personality
and less deterioration and impairment in social and occupational functioning than schizophrenia,
and individuals with delusional disorder tend to come to clinical attention for the first time at a later
age. Individuals with symptom presentations consistent with delusional disorder (e.g. delusions and
related, circumscribed hallucinations) but who have not met the minimum duration requirement
of 3 months should not be assigned a diagnosis of schizophrenia, even though the combination
of persistent delusions and related hallucinations technically meets diagnostic requirements for
schizophrenia. Instead, a diagnosis of other specified primary psychotic disorder is more appropriate
in such cases.
Boundary with moderate or severe depressive episodes in single episode
depressive disorder, recurrent depressive disorder, and bipolar type I and bipolar
type II disorders
Psychotic symptoms may also occur during moderate or severe depressive episodes. Delusions
during depressive episodes may resemble delusions observed in schizophrenia, and are commonly
persecutory or self-referential (e.g. being pursued by authorities because of imaginary crimes).
Delusions of guilt (e.g. falsely blaming oneself for wrongdoing), poverty (e.g. being bankrupt)
or impending disaster (perceived to have been brought on by the individual), as well as somatic
delusions (e.g. of having contracted some serious disease) and nihilistic delusions (e.g. believing
body organs do not exist), are also known to occur. Experiences of passivity, influence or control
(e.g. thought insertion, thought withdrawal or thought broadcasting) may also occur in moderate or
severe depressive episodes. Hallucinations are usually transient, and rarely occur in the absence of
Schizophrenia and other primary psychotic disorders | Schizophrenia

170 - QE21 Hazardous gambling or betting
QE21  Hazardous gambling or betting

171 - QE22 Hazardous gaming
QE22  Hazardous gaming
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Secondary-parented categories in disorders due to addictive
behaviours
Hazardous gambling or betting and hazardous gaming
These categories are not considered to be mental disorders; instead, they are included in the
grouping of problems associated with health behaviours in Chapter 24 on factors influencing
health status or contact with health services.
Hazardous gambling or betting
Hazardous gambling or betting refers to a pattern of gambling or betting that appreciably increases
the risk of harmful physical or mental health consequences to the individual or to others around
the individual. The increased risk may be from the frequency of gambling or betting, the amount
of time spent on these activities, the context of gambling or betting, the neglect of other activities
and priorities, risky behaviours associated with gambling or betting or its context, the adverse
consequences of gambling or betting, or a combination of these factors. The pattern of gambling or
betting often persists in spite of awareness of increased risk of harm to the individual or to others.
This category may be used when the pattern of gambling or betting warrants attention and advice
from health professionals but does not meet the diagnostic requirements for gambling disorder.
Hazardous gaming
Hazardous gaming refers to a pattern of gaming, either online or offline, that appreciably increases
the risk of harmful physical or mental health consequences to the individual or to others around
the individual. The increased risk may be from the frequency of gaming, the amount of time
spent on these activities, the neglect of other activities and priorities, risky behaviours associated
with gaming or its context, the adverse consequences of gaming, or a combination of these
factors. The pattern of gaming often persists in spite of awareness of increased risk of harm to the
individual or to others. This category may be used when the pattern of gaming behaviour warrants
attention and advice from health professionals but does not meet the diagnostic requirements for
gaming disorder.
QE21
QE22
Hazardous gambling or betting and hazardous gaming
517
Disorders due to substance use or addictive behaviours
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

172 - Impulse control disorders
Impulse control disorders
519
Impulse control disorders
6C70
6C71
Kleptomania
Impulse control disorders
Pyromania
Impulse control disorders are characterized by the repeated failure to resist a strong impulse,
drive or urge to perform an act that is rewarding to the person – at least in the short term – despite
longer-term harm either to the individual or to others, marked distress about the behaviour
pattern, or significant impairment in personal, family, social, educational, occupational or other
important areas of functioning. Impulse control disorders involve a range of specific behaviours,
including fire setting, stealing, sexual behaviour and explosive aggressive outbursts.
The episodes of the behaviour involved in impulse control disorders are often preceded by a rise
in tension or affective arousal, which can also occur when attempting to resist the behaviour.
The episodes of the behaviour are typically followed by pleasure, gratification or relief of tension.
However, over the course of the disorder, individuals may report less awareness of building
tension or arousal prior to the behaviour, or a reduction in pleasure or gratification following
the behaviour. They may also experience feelings of guilt or shame following the behaviour.
The behaviours involved in impulse control disorders are not fully attributable to another mental
disorder, the direct central nervous system effects of a medication or substance – including
substance intoxication and withdrawal – or another medical condition not classified under
mental, behavioural and neurodevelopmental disorders.
6C72
6C73
Intermittent explosive disorder
Compulsive sexual behaviour disorder
6C7Y
6C7Z
Impulse control disorder, unspecified.
Other specified impulse control disorder
Impulse control disorders
Impulse control disorders include the following:

173 - 6C70 Pyromania
6C70 Pyromania
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Pyromania
Essential (required) features
• The presentation is characterized by a recurrent failure to control strong impulses to set
fires, resulting in multiple acts of, or attempts at, setting fire to property or other objects.
• There is a lack of apparent motive (e.g. monetary gain, revenge, sabotage, political
statement, attracting recognition) for the acts of, or attempts at, fire setting.
• The individual exhibits persistent fascination or preoccupation with fire and related stimuli
(e.g. watching fires, building fires, fascination with firefighting equipment).
• The individual experiences increased tension or affective arousal prior to instances of, or
attempts at, fire setting.
• The individual experiences pleasure, excitement, relief or gratification during and
immediately following the act of setting the fire, and while witnessing its effects or
participating in its aftermath.
• Acts of, or attempts at, fire setting are not better accounted for by a disorder of intellectual
development, another mental disorder (e.g. a manic episode) or substance intoxication.
Additional clinical features
• The impulse to set fires in individuals with pyromania may involve a careful planning
phase to determine how to commit the act, with a concomitant gradual increase of tension
or affective arousal; in other instances, fire setting may occur opportunistically without
planning. In both cases, there is a lack of control over urges or impulses to set fires.
• In individuals with pyromania, fire setting may occur in response to feelings of depressed
mood, anxiety, boredom, loneliness or other negative affective states. Although not
diagnostically determinative, consideration of the relationship between emotional
and behavioural cues and fire-setting behaviour may be an important aspect of
treatment planning.
• Many individuals with pyromania exhibit impairments in social skills and a history of
learning difficulties. Furthermore, individuals with pyromania – particularly women –
often report histories of exposure to trauma, including sexual abuse, and self-harm.
• Conduct-dissocial disorder, attention deficit hyperactivity disorder and adjustment
disorder are frequently associated with fire setting. Furthermore, pyromania appears
commonly to co-occur with disorders due to substance use, gambling disorder, mood
disorders, impulse control disorders, and disruptive behaviour and dissocial disorders.
6C70
Impulse control disorders | Pyromania
521
Impulse control disorders
Impulse control disorders | Pyromania
Boundary with normality (threshold)
• Intentional fire setting can occur for a variety of reasons. Individuals may set fires for
profit or to conceal a crime, as an act of revenge, to commit sabotage or make a political
statement, or to attract recognition (e.g. deliberately setting a fire to then be the first one
to discover it and put it out). Moreover, interest in fires is typical during early childhood,
and young children may accidentally or intentionally set fires as a part of developmental
experimentation (e.g. playing with matches, lighters, fire). A diagnosis of pyromania is not
appropriate in such cases.
Course features
• Although the longitudinal course is unknown, pyromania appears to be chronic if
untreated.
• Among individuals with pyromania, fire-setting events tend to be episodic, to wax and
wane over time, and progressively to become more frequent and intense.
Developmental presentations
• The typical age of onset has not yet been definitively established, but current evidence
suggests that most fire-setting behaviour begins during adolescence or early adulthood.
• Prevalence rates of pyromania, as distinct from fire setting and arson, suggest that the
disorder is rare, particularly among children. In contrast, interest in fires among young
children is common, and children may set fires accidentally (e.g. playing with matches)
or purposefully without having the additional required diagnostic features of pyromania.
A diagnosis of pyromania is not appropriate under these circumstances. However, firesetting behaviour among children and adolescents is a significant problem, as nearly half
of arson arrests are among young people below the age of 18 years. Lifetime prevalence of
fire setting among adults is estimated at 1.13%, and is lowest among older adults.
• Limited information about the presentation of pyromania in adolescents is available,
making it difficult to determine whether it is similar to the adult presentation of the
disorder. The rising tension and relief reported among adults has not been as clearly
documented among young people.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Pyromania and fire-setting behaviour is more common among males.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with attention deficit hyperactivity disorder
Individuals with attention deficit hyperactivity disorder – particularly children and adolescents –
may set fires impulsively. However, impulsivity and disregard for consequences in attention deficit
hyperactivity disorder are typically observed across multiple contexts and situations. Furthermore,
individuals with attention deficit hyperactivity disorder do not exhibit the diagnostic features of
preoccupation with fire, tension or affective arousal prior to fire setting, and gratification or relief
once the act is committed that are characteristic of pyromania.
Boundary with bipolar type I disorder and schizophrenia and other primary
psychotic disorders
Fire setting may, in rare instances, be associated with manic or mixed episodes in individuals
with bipolar type I disorder. However, in such cases, fire-setting does not continue once the mood
episode has ended, whereas in individuals with pyromania fire setting is not exclusively associated
with manic or mixed episodes. Some individuals with delusions or hallucinations may set fires
in response to command hallucinations or in the context of a delusional system, and pyromania
should not be assigned in these cases.
Boundary with obsessive-compulsive disorder
Fire setting can sometimes be described as “compulsive” by lay people and also by some health
professionals. Compulsions observed in obsessive-compulsive disorder are almost never
experienced as inherently pleasurable; they typically occur in response to intrusive, unwanted
and typically anxiety-provoking obsessions. In contrast, fire setting in pyromania is preceded by
an increasing sense of tension or affective arousal, and is followed by an experience of pleasure,
excitement or gratification.
Boundary with conduct-dissocial disorder and personality disorder with prominent
dissocial features
Individuals with conduct-dissocial disorder and personality disorder with prominent dissocial
features may set fires as part of a more pervasive pattern of antisocial behaviour, and often for
discernible motives such as personal gain or revenge rather than to relieve tension or affective
arousal. Individuals with pyromania do not typically exhibit antisocial behaviour apart from their
fire setting.
Boundary with the effects of psychoactive substances, including medications
Fire setting may occur during substance intoxication. Pyromania should not be diagnosed
if the fire setting is better accounted for by intoxication or the disinhibiting effects of alcohol,
Impulse control disorders | Pyromania

174 - 6C71 Kleptomania
6C71 Kleptomania
523
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Impulse control disorders | Kleptomania
drugs or medication. However, among individuals with pyromania, alcohol and substance use
may be associated with fire setting. The presence of features of pyromania outside of episodes of
intoxication is helpful in making this distinction.
Boundary with disinhibition in dementia and secondary personality change
Some individuals with dementia or secondary personality change may set fires as a part of a more
general pattern of disinhibition of impulse control due to brain damage. A separate diagnosis of
pyromania should not be assigned in such cases.
Boundary with disorders associated with impairment of cognitive or intellectual
functioning
Some individuals with dementia, disorders of intellectual development, or cognitive or intellectual
impairment associated with other conditions may set fires due to their impaired judgement
without exhibiting the other features of pyromania.
Kleptomania
Essential (required) features
• The presentation is characterized by a recurrent failure to control strong impulses to
steal objects.
• There is a lack of apparent motive for stealing objects (e.g. objects are not acquired for
personal use or monetary gain).
• The individual experiences increased tension or affective arousal prior to instances of theft
or attempted theft.
• The individual experiences pleasure, excitement, relief or gratification during and
immediately following the act of stealing.
• Acts of theft or attempted theft are not better accounted for by a disorder of intellectual
development, another mental disorder (e.g. a manic episode) or substance intoxication.
Additional clinical features
• Some individuals with kleptomania report amnesia or experience other dissociative
symptoms during the act of stealing, and may have difficulty remembering their affective
state prior to and immediately after the act, including whether they experienced mounting
tension or arousal before and gratification or relief after stealing. Furthermore, over the
course of the disorder, individuals may report less awareness of increased tension or
arousal prior to incidents of stealing.
• In individuals with kleptomania, stealing may occur in response to feelings of depressed
mood, anxiety, boredom, loneliness or other negative affective states. Although not
6C71
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
diagnostically determinative, consideration of the relationship between emotional and
behavioural cues and stealing behaviour may be an important aspect of treatment planning.
• After stealing items, many individuals with kleptomania experience guilt or shame for
having committed a theft, but these feelings do not prevent recurrence of the behaviour.
Although individuals with kleptomania may desire the items they steal and have a practical
use for such items, they do not need these items (e.g. they have multiples of the same item,
they have more than adequate financial resources to purchase the stolen item).
• Rates of co-occurrence of mood disorders, anxiety and fear-related disorders, other
impulse control disorders, substance use disorders, and obsessive-compulsive disorder
among individuals with kleptomania are higher than in the general population.
Boundary with normality (threshold)
• Stealing behaviour is common, and most individuals who steal do so because they need
or want something they cannot afford, as an act of mischief, or as an expression of anger
or vengeance. The diagnosis of kleptomania requires that the individual does not need
or could afford to buy the stolen items, but cannot resist the urge to steal. Moreover, in
kleptomania, the theft is accompanied by a sense of tension before committing the act and
a sense of gratification, pleasure or relief during and immediately after the act. Individuals
who steal for monetary gain due to the financial implications of their substance use or
gambling should not be diagnosed with kleptomania.
Course features
• The course of kleptomania is variable, and may take different forms: sporadic, with long
periods of remission between brief episodes; episodic, with lengthy periods of stealing
followed by periods of remission; or chronic, with fluctuations in intensity.
• Treatment-seeking individuals with kleptomania commonly report a long history of
shoplifting (e.g. for more than 10 years) prior to seeking help.
Developmental presentations
• Onset of kleptomania may occur at any time, but is most common during late adolescence.
Onset during late adulthood is rare.
Impulse control disorders | Kleptomania
525
Impulse control disorders
Sex- and/or gender-related features
• Women are significantly more likely to be diagnosed with kleptomania.
• Gender differences in clinical presentation or severity of symptoms have not been observed.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with attention deficit hyperactivity disorder
Individuals with attention deficit hyperactivity disorder – particularly children and adolescents
– may steal impulsively. However, impulsivity and disregard for consequences in attention deficit
hyperactivity disorder are typically observed across multiple contexts and situations. Furthermore,
individuals with attention deficit hyperactivity disorder do not exhibit tension or affective arousal
prior to stealing, and gratification or relief once the theft is committed.
Boundary with bipolar type I disorder and schizophrenia and other primary
psychotic disorders
Stealing may be associated with manic or mixed episodes in individuals with bipolar type I disorder.
However, in such cases, stealing does not continue once the mood episode has ended, whereas
in individuals with kleptomania stealing is not exclusively associated with mood episodes. Some
individuals with delusions or hallucinations may steal in response to command hallucinations
or in the context of a delusional system, and kleptomania should not be diagnosed in such cases.
Boundary with obsessive-compulsive disorder
Stealing in kleptomania can sometimes be described as “compulsive” by lay people and also by
some health professionals. Compulsions observed in obsessive-compulsive disorder are almost
never experienced as inherently pleasurable; they typically occur in response to intrusive,
unwanted and typically anxiety-provoking obsessions. In contrast, stealing in kleptomania is
preceded by an increasing sense of tension or affective arousal and is followed by an experience of
pleasure, excitement or gratification.
Boundary with hoarding disorder
Some individuals with hoarding disorder steal objects as part of a pattern of excessive accumulation,
and individuals with kleptomania may hoard stolen objects. However, individuals with hoarding
disorder accumulate possessions to the extent that living spaces becoming so cluttered that their
use or safety is compromised.
Boundary with conduct-dissocial disorder and personality disorder with prominent
dissocial traits
Individuals with conduct-dissocial disorder and personality disorder with prominent dissocial
features may commit theft as part of more pervasive pattern of antisocial behaviour, and often for
discernible motives such as personal gain or revenge rather than to relieve symptoms of tension.
Individuals with kleptomania do not exhibit antisocial behaviour other than stealing.
Impulse control disorders | Kleptomania

175 - 6C72 Compulsive sexual behaviour disorder
6C72 Compulsive sexual behaviour disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with the effects of psychoactive substances, including medications
Episodes of stealing may occur during substance intoxication. Individuals taking prescribed
dopamine agonists – for example, for Parkinson disease or restless legs syndrome – may exhibit
repetitive stealing behaviour with onset corresponding to use of the medication. Kleptomania
should not be diagnosed if stealing is better accounted for by intoxication or the disinhibiting
effects of alcohol, drugs or medication. However, among individuals with kleptomania, alcohol
and substance use may be associated with acts of theft or attempted theft. The presence of features
of kleptomania outside of episodes of intoxication is helpful in making this distinction.
Boundary with disinhibition in dementia and secondary personality change
Some individuals with dementia or secondary personality change may steal objects as a part
of a more general pattern of disinhibition of impulse control due to brain damage. A separate
diagnosis of kleptomania should not be assigned in such cases.
Boundary with disorders associated with impairment of cognitive or intellectual
functioning
Some individuals with dementia, disorders of intellectual development, or cognitive or intellectual
impairment associated with other conditions may steal objects due to their impaired judgement
without exhibiting the other features of kleptomania.
Compulsive sexual behaviour disorder
Essential (required) features
• The presentation is characterized by a persistent pattern of failure to control intense,
repetitive sexual impulses or urges resulting in repetitive sexual behaviour, manifested in
one or more of the following.
• Engaging in repetitive sexual behaviour has become a central focus of the individual’s
life to the point of neglecting health and personal care or other interests, activities and
responsibilities.
• The individual has made numerous unsuccessful efforts to control or significantly reduce
repetitive sexual behaviour.
• The individual continues to engage in repetitive sexual behaviour despite adverse
consequences (e.g. marital conflict due to sexual behaviour, financial or legal
consequences, negative impact on health).
• The individual continues to engage in repetitive sexual behaviour even when they derive
little or no satisfaction from it.
• The pattern of failure to control intense, repetitive sexual impulses or urges and resulting
repetitive sexual behaviour is manifested over an extended period of time (e.g. 6 months
or more).
• The pattern of failure to control intense, repetitive sexual impulses or urges and resulting
repetitive sexual behaviour is not better accounted for by another mental disorder (e.g.
a manic episode) or other medical condition, and is not due to the effects of a substance
or medication.
6C72
Impulse control disorders | Compulsive sexual behaviour disorder
527
Impulse control disorders
• The pattern of repetitive sexual behaviour results in marked distress or significant
impairment in personal, family, social, educational, occupational or other important
areas of functioning. If functioning is maintained, it is only through significant additional
effort. Distress that is entirely related to moral judgements and disapproval about sexual
impulses, urges or behaviours is not sufficient to meet this requirement.
Additional clinical features
• Compulsive sexual behaviour disorder may be expressed in a variety of behaviours,
including sexual behaviour with others, masturbation, use of pornography, cybersex
(internet sex), telephone sex and other forms of repetitive sexual behaviour.
• Individuals with compulsive sexual behaviour disorder often engage in sexual behaviour in
response to feelings of depression, anxiety, boredom, loneliness or other negative affective
states. Although not diagnostically determinative, consideration of the relationship
between emotional and behavioural cues and sexual behaviour may be an important
aspect of treatment planning.
• Individuals who make religious or moral judgements about their own sexual behaviour
or view it with disapproval, or who are concerned about the judgements and disapproval
of others or about other potential consequences of their sexual behaviour, may describe
themselves as “sex addicts” or describe their sexual behaviour as “compulsive” or similar
terms. In such cases, it is important to examine carefully whether such perceptions are only
a result of internal or external judgements or potential consequences, or whether there is
evidence that impaired control over sexual impulses, urges or behaviours and the other
diagnostic requirements of compulsive sexual behaviour disorder are actually present.
Boundary with normality (threshold)
• There is wide variation in the nature and frequency of individuals’ sexual thoughts,
fantasies, impulses and behaviours. This diagnosis is only appropriate when the individual
experiences intense, repetitive sexual impulses or urges that are experienced as irresistible
or uncontrollable, leading to repetitive sexual behaviour, and when the pattern of repetitive
sexual behaviour results in marked distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning. Individuals with
high levels of sexual interest and behaviour (e.g. due to a high sex drive) who do not exhibit
impaired control over their sexual behaviour and significant distress or impairment in
functioning should not be diagnosed with compulsive sexual behaviour disorder. The
diagnosis should also not be assigned to describe high levels of sexual interest and
behaviour (e.g. masturbation) that are common among adolescents, even when this is
associated with distress.
• Compulsive sexual behaviour disorder should not be diagnosed based on distress related
to moral judgements and disapproval about sexual impulses, urges or behaviours that
would otherwise not be considered to be indicative of psychopathology (e.g. a woman who
believes that she should not have sexual impulses at all; a religious young man who believes
Impulse control disorders | Compulsive sexual behaviour disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
that he should never masturbate; a person who is distressed about their homosexual
attraction or behaviour). Similarly, compulsive sexual behaviour disorder cannot be
diagnosed based solely on distress related to real or feared social disapproval of sexual
impulses or behaviours.
• Compulsive sexual behaviour disorder should not be diagnosed based solely on relatively
brief periods (e.g. up to several months) of increased sexual impulses, urges and behaviours
during transitions to contexts that involve increased availability of sexual outlets that
previously did not exist (e.g. moving to a new city, a change in relationship status).
Course features
• Many individuals with compulsive sexual behaviour disorder report a history of sexually
acting out during pre-adolescence or adolescence (e.g. risky sexual behaviour, masturbation
to modulate negative affect, extensive use of pornography).
Developmental presentations
• Compulsive sexual behaviour disorder in adulthood has been associated with high rates
of childhood traumas, including sexual abuse, with women reporting higher rates and
severity of abuse.
• Adolescents and adults with compulsive sexual behaviour disorder commonly experience
high rates of co-occurring mental, behavioural and neurodevelopmental disorders,
including disorders due to substance use.
• Assessing the presence of compulsive sexual behaviour disorder may be particularly
challenging during adolescence due to divergent views regarding the appropriateness
of sexual behaviour during this life stage. Increased frequency of sexual behaviour or
uncontrolled sexual urges associated with rapidly changing hormonal levels during
this developmental stage may be considered to reflect normal adolescent experiences.
Conversely, frequent or risky sexual behaviour among adolescents may be considered
abnormal due to the potential for the behaviour to interfere with social and
emotional development.
Culture-related features
• Cultural and subcultural variation may exist for compulsive sexual behaviour. Norms
for what is considered appropriate sexual behaviour, activities judged unacceptable, and
perceptions regarding gender roles influence sexual activity. These factors may affect norms
regarding masturbation, use of pornography, having multiple sexual partners concurrently
and the number of lifetime sexual partners.
Impulse control disorders | Compulsive sexual behaviour disorder
529
Impulse control disorders
• Culture shapes the distress caused by engaging in sexual behaviour and whether sexual
activity is viewed as disordered. For example, in cultures where masculine ideals are
associated with sexual conquest, higher rates of sexual behaviour may be considered
normative, and should not be the primary basis for assigning a diagnosis.
Sex- and/or gender-related features
• Men are more likely to be diagnosed with compulsive sexual behaviour disorder.
• Women with compulsive sexual behaviour disorder are more likely than men to report a
history of childhood sexual abuse.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with bipolar and related disorders
Increased sexual impulses, urges or behaviours and impaired ability to control them can occur
during manic, mixed or hypomanic episodes. A diagnosis of compulsive sexual behaviour disorder
should only be assigned if there is evidence of persistent failure to control intense, repetitive sexual
impulses, urges or behaviours and the presence of all other diagnostic requirements outside of
mood episodes.
Boundary with obsessive-compulsive disorder
Although the word “compulsive” is included in the name of this condition, sexual behaviour in
compulsive sexual behaviour disorder is not considered to be a true compulsion. Compulsions
in obsessive-compulsive disorder are almost never experienced as inherently pleasurable; they
commonly occur in response to intrusive, unwanted and typically anxiety-provoking thoughts,
which is not the case with sexual behaviour in compulsive sexual behaviour disorder.
Boundary with personality disorder
Some individuals with personality disorder may engage in repetitive sexual behaviour as a
maladaptive regulation strategy (e.g. to prevent or reduce emotional distress or to stabilize their
sense of self). Although both diagnoses can be assigned together, if the sexual behaviour is
entirely accounted for by emotion dysregulation or other core features of personality disorder, an
additional diagnosis of compulsive sexual behaviour disorder is not warranted.
Boundary with paraphilic disorders
The core feature of compulsive sexual behavioural disorder is a persistent pattern of failure to
control intense repetitive sexual impulses or urges resulting in repetitive sexual behaviour that
results in marked distress or impairment in functioning. Paraphilic disorders, on the other hand,
are characterized by persistent and intense patterns of atypical sexual arousal manifested in sexual
thoughts, fantasies, urges or behaviours, and have resulted in actions towards individuals whose
age or status renders them unwilling or unable to consent, or are associated with marked distress
or significant risk of injury or death. If an individual with a paraphilic disorder is able to exercise
Impulse control disorders | Compulsive sexual behaviour disorder

176 - 6C73 Intermittent explosive disorder
6C73 Intermittent explosive disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
some degree of control over the behavioural expressions of the arousal pattern, an additional
diagnosis of compulsive sexual behavioural disorder is generally not warranted. If, however,
the diagnostic requirements of both compulsive sexual behavioural disorder and a paraphilic
disorder are met, both diagnoses may be assigned.
Boundary with the effects of psychoactive substances, including medications
Use of specific prescribed medications or illicit substances (e.g. dopamine agonists such as
pramipexole for Parkinson disease or restless legs syndrome or illicit substances such as
methamfetamine) can sometimes cause impaired control over sexual impulses, urges or
behaviours due to their direct effects on the central nervous system, with onset corresponding
to use of the substance or medication. Compulsive sexual behaviour disorder should not be
diagnosed in such cases.
Boundary with disorders due to substance use
Episodes of impulsive or disinhibited sexual behaviour may occur during substance intoxication.
At the same time, co-occurrence of compulsive sexual behaviour disorder and substance use is
common, and some individuals with compulsive sexual behaviour disorder use substances with
the intention of engaging in sexual behaviour or to enhance pleasure from it. Distinguishing
between compulsive sexual behaviour disorder and repetitive patterns of substance use with
associated sexual behaviour is therefore a complex clinical judgement based on an assessment of
the sequencing, context and motivations of the relevant behaviours. A diagnosis of compulsive
sexual behaviour disorder may be assigned together with a disorder due to substance use if the
diagnostic requirements for both are met.
Boundary with dementia and medical conditions not classified under mental,
behavioural and neurodevelopmental disorders
Some individuals with dementia, diseases of the nervous system or other medical conditions
that have effects on the central nervous system may exhibit failure to control sexual impulses,
urges or behaviours as a part of a more general pattern of disinhibition of impulse control due
to neurocognitive impairment. A separate diagnosis of compulsive sexual behaviour disorder
should not be assigned in such cases.
Intermittent explosive disorder
Essential (required) features
• The presentation is characterized by a pattern of recurrent, brief, explosive episodes
involving verbal aggression (e.g. verbally attacking another person, temper outbursts,
yelling) or physical aggression in an individual who is at least 6 years of age – when inhibition
of angry outbursts is expected to have been attained – or equivalent developmental level
is required for diagnosis. Episodes of physical aggression may result in significant damage
or destruction of property or physical assault involving personal injury; however, such
outcomes are not required for the diagnosis.
• The intensity of the outbursts or the degree of the aggressiveness is grossly out of proportion
to the provocation or precipitating event or situation.
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Impulse control disorders | Intermittent explosive disorder
531
Impulse control disorders
• The explosive outbursts must occur regularly over an extended period of time (e.g. at least
3 months), representing a persistent pattern of aggressive behaviour. A lower frequency
threshold (e.g. several times over the course of a year) may be used for high-intensity
outbursts with serious negative consequences, such as physically assaulting another person,
whereas a higher frequency threshold (e.g. two or more times per week) should be used
for episodes characterized by verbal aggression or non-assaultive and non-destructive
physical aggression.
• The aggressive behaviours are clearly impulsive or reactive in nature, and represent a failure
to control aggressive impulse. That is, the aggressive acts are not planned or instrumental
in achieving a desired outcome.
• The frequency and intensity of explosive episodes is outside the limits of normal variation
expected for the individual’s age and developmental level.
• The explosive outbursts are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. autism spectrum disorder, attention deficit hyperactivity
disorder, oppositional defiant disorder with chronic irritability-anger, conduct-dissocial
disorder, delirium).
• The explosive outbursts are not due to the effects of a substance or medication on the central
nervous system (e.g. amfetamines), including substance intoxication and withdrawal, or
due to a disease of the nervous system.
• The behaviour pattern results in significant distress for the individual with the disorder,
or significant impairment in personal, family, social, educational, occupational or other
important areas of functioning.
Additional clinical features
• Explosive episodes may be associated with affective symptoms (anger, irritability,
rage) during aggressive outbursts. Sometimes the aggressive episodes are preceded by
premonitory symptoms such as tremor or chest tightness, or a more general feeling of
tension or arousal.
• Explosive outbursts in intermittent explosive disorder are typically triggered by perceived
threats in social settings (even when there is no real threat but, for example, threat is
perceived based on an inaccurate attribution of hostility to others), or by frustration when
facing obstacles in the course of daily life.
• A wide array of aggressive behaviours could fulfil the requirements for intermittent
explosive disorder, ranging from verbal aggression to physical assault and destruction
of property.
• After the explosive episode, the individual often, but not always, experiences depressed
mood or fatigue, or other negative emotions such as regret, remorse, guilt or shame.
• Some individuals with intermittent explosive disorder exhibit nonspecific abnormalities
on neurological examination (e.g. “soft signs”) and in EEGs that do not constitute a
diagnosable disease of the nervous system. In the presence of such findings, intermittent
explosive disorder may still be diagnosed if the diagnostic requirements are met.
• Many individuals with intermittent explosive disorder have a history of exposure to
traumatic events, witnessing violence, or childhood physical abuse.
• Intermittent explosive disorder often co-occurs with depressive disorders, anxiety and
fear-related disorders, disorders due to substance use, and eating disorders (especially
those involving binge eating).
Impulse control disorders | Intermittent explosive disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• Aggressive outbursts – particularly verbal ones – are common, especially when an
individual is under stress, and are not in themselves indicative of psychopathology. The
mere occurrence of one or two isolated explosive episodes is not sufficient for the diagnosis,
regardless of the severity or consequences of the behaviour. This diagnosis should only be
considered when the intensity of the outbursts or the degree of the aggressiveness is grossly
out of proportion to the provocation or precipitating event or situation, and the outbursts
occur regularly over an extended period of time, representing a persistent pattern of
aggressive behaviour.
Course features
• The mean age of onset of intermittent explosive disorder is between 10 and 16 years. Age of
onset is typically earlier than common co-occurring disorders such as depressive disorders,
anxiety and fear-related disorders, eating disorders and disorders due to substance use.
• Intermittent explosive disorder tends to exhibit a persistent course over many years.
Aggressive behaviour in general tends to diminish over time, and the prevalence of
intermittent explosive disorder correspondingly diminishes over the lifespan.
Developmental presentations
• Early in the course of intermittent explosive disorder, children typically display temper
tantrums associated with verbal outbursts and aggression against objects, although
typically without serious destruction of objects or assault against others.
• During adolescence, explosive outbursts often escalate to include destruction of objects or
property, or physical assault against others.
Culture-related features
• Variation in prevalence of intermittent explosive disorder may be related to cultural norms
regarding emotion regulation. Some cultures emphasize emotional restraint, equanimity,
interpersonal harmony and social conformity such that individuals suppress or mute overt
expressions of hostility or anger. In other cultures, freer expressions of negative affect
are more typical. Whether or not a verbal expression is considered aggressive should be
evaluated within the context of what is normative within the individual’s culture.
Impulse control disorders | Intermittent explosive disorder
533
Impulse control disorders
• Societies vary in the degree to which they consider anger a harmful emotion, associated
with substantial personal and social risk. Some cultural concepts of distress are attributed
to pent-up anger, such as ataque de nervios (attack of nerves) in Latin America and hwabyung (anger illness) in the Republic of Korea. It may be appropriate to apply a diagnosis of
intermittent explosive disorder to some behavioural patterns of ataque de nervios involving
paroxysmal violence and destruction of property.
• The typical level of expressed emotionality varies cross-culturally, including by gender and
age. Cultural minorities, immigrants or individuals in post-conflict settings may be at risk
of being mislabelled as excessively angry because of this variation. Moreover, clinicians may
misattribute anger to a single triggering event when it is in reaction to the accumulation of
multiple environmental stressors (e.g. discrimination, losses, displacement, limited social
support, powerlessness, injustice). Clinicians should consider the larger social context and
how it may be related to the expression of anger before assigning a diagnosis.
Sex- and/or gender-related features
• Although it was originally believed that intermittent explosive disorder was much more
prevalent among males, recent community surveys suggest similar prevalence rates by
gender. However, serious physical assault is a more common manifestation of the disorder
in males, whereas less serious physical and verbal aggression is more characteristic
of females.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with autism spectrum disorder
Explosive outbursts with aggressive behaviours may occur in some individuals with autism
spectrum disorder. These outbursts are usually associated with a specific trigger that is related to the
core symptoms of autism spectrum disorder (e.g. a change in routine, aversive sensory stimulation,
anxiety, rigidity when the individual’s thoughts or behaviours are interrupted). Individuals with
intermittent explosive disorder do not exhibit other features of social communication difficulties
and restricted or repetitive behaviours that are characteristic of autism spectrum disorder.
Boundary with attention deficit hyperactivity disorder
Intermittent explosive disorder and attention deficit hyperactivity disorder are both characterized
by impulsive behaviour. However, intermittent explosive disorder is specifically characterized by
intermittent severe aggressive outbursts rather than ongoing generalized behavioural impulsivity
that may be seen in attention deficit hyperactivity disorder. Both diagnoses may be assigned if the
full diagnostic requirements for each are met.
Boundary with oppositional defiant disorder
Regularly occurring severe temper outbursts that are grossly out of proportion in intensity or
duration to the provocation may also occur in the context of oppositional defiant disorder with
chronic irritability-anger, particularly in response to demands by authority figures. In such cases,
Impulse control disorders | Intermittent explosive disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
an additional diagnosis of intermittent explosive disorder should not be assigned. Individuals
with oppositional defiant disorder with chronic irritability-anger typically display other features
of oppositional defiant disorder, including defiant, headstrong or vindictive behaviours, which
are not characteristic of intermittent explosive disorder. In addition, individuals with intermittent
explosive disorder are more likely to exhibit significant physical aggression.
Boundary with conduct-dissocial disorder
People with intermittent explosive disorder may come into conflict with other people and with
law enforcement because of their explosive outbursts, but these episodes do not constitute a
more general pattern of antisocial behaviour characteristic of conduct-dissocial disorder (e.g.
rule violations, lying, theft). In addition, intermittent explosive disorder is characterized by
impulsive aggression, while aggression in conduct-dissocial disorder is often premeditated and
instrumental.
Boundary with personality disorder
Due to interpersonal, occupational and other consequences of a recurrent pattern of verbal and
physical aggression, some individuals with intermittent explosive disorder are likely to meet the
diagnostic requirements for personality disorder with prominent features of disinhibition. Both
diagnoses may be assigned if the full diagnostic requirements for each are met, but the utility of
assigning an additional diagnosis of personality disorder in such cases depends on the specific
clinical situation.
Boundary with other mental, behavioural and neurodevelopmental disorders
Aggressive outbursts may occur as a part of a number of mental disorders (e.g. disorders
specifically associated with stress, mood disorders, schizophrenia and other primary psychotic
disorders). In general, an additional diagnosis of intermittent explosive disorder should not be
given when the outbursts are better accounted for by another disorder.
Boundary with the effects of psychoactive substances, including medications
Explosive aggressive behaviours may occur during substance intoxication or withdrawal.
Intermittent explosive disorder should not be diagnosed if the outbursts are solely attributable
to intoxication or the disinhibiting effects of alcohol, drugs or medication. However, among
individuals with intermittent explosive disorder, alcohol and substance use are commonly
associated with episodes of aggressive behaviour. In these situations, the distinction should be
made based on the presence of features of intermittent explosive disorder at times other than
during episodes of intoxication.
Boundary with malingering
Some individuals who engage in recurrent acts of verbal or physical aggression may falsely
report additional symptoms consistent with a diagnosis of intermittent explosive disorder, with
the intent of obtaining a mental disorder diagnosis to avoid criminal charges or other negative
consequences. Intermittent explosive disorder should not be diagnosed in such cases.
Boundary with dementia and other medical conditions
The diagnosis of intermittent explosive disorder should not be assigned when the impulsive
aggressive behaviours are entirely explained by dementia, a disease of the nervous system –
including stroke – or another medical condition not classified under mental, behavioural and
neurodevelopmental disorders (e.g. a brain tumour).
Impulse control disorders | Intermittent explosive disorder

177 - 6C7Y Other specified impulse control disorder
6C7Y Other specified impulse control disorder

178 - 6C7Z Impulse control disorder, unspecified
6C7Z Impulse control disorder, unspecified
535
Impulse control disorders
Other specified impulse control disorder
Essential (required) features
• The presentation is characterized by symptoms that share primary clinical features with
other impulse control disorders; that is, persistently repeated behaviours in which there
is failure to resist an impulse, drive or urge to perform an act that is rewarding to the
person – at least in the short term – despite negative consequences such as longer-term
harm either to the individual or to others.
• The symptoms do not fulfil the diagnostic requirements for any other disorder in the
impulse control disorders grouping.
• The symptoms are not characterized by recurrent and habitual actions directed at the
integument (e.g. skin and hair), which should be classified under body-focused repetitive
behaviour disorders.
• The symptoms are not characterized by gambling, gaming or other addictive behaviours.
• The symptoms are not better accounted for by another mental disorder (e.g. dementia, a
disorder due to addictive behaviours, an obsessive-compulsive or related disorder).
• The symptoms or behaviours are not developmentally appropriate or culturally sanctioned.
• The symptoms or behaviours are not a manifestation of another medical condition, and
are not due to the effects of a substance or medication on the central nervous system (e.g.
methamfetamine or dopamine agonists such as pramipexole for Parkinson disease or
restless legs syndrome), including substance intoxication and withdrawal effects.
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning.
Impulse control disorder, unspecified
6C7Y
6C7Z
Impulse control disorders | Other specified impulse control disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

179 - Disruptive behaviour and dissocial disorders
Disruptive behaviour and dissocial disorders
537
Disruptive behaviour and dissocial disorders
6C90
Disruptive behaviour and
dissocial disorders
Oppositional defiant disorder
Disruptive behaviour and dissocial disorders are characterized by persistent behaviour problems
across multiple settings, with onset commonly, but not exclusively, during childhood. When
present, these problems often persist into adulthood. These disorders are characterized by
behaviours that range from those described as disruptive – that is, markedly and persistently
defiant, disobedient, provocative or spiteful – to behaviours that are considered dissocial because
they persistently violate the basic rights of others or major age-appropriate societal norms, rules
or laws.
A majority of individuals commit isolated acts of aggression or rule violation at some point in
their lives, and this does not warrant the diagnosis of a disruptive behaviour or dissocial disorder.
In all cases, the behaviours characteristic of the disorders in this grouping must clearly depart
from the normal range for the individual’s age and gender, given their sociocultural context.
Disruptive behaviour and dissocial disorders may co-occur with other mental, behavioural
and neurodevelopmental disorders. However, a separate diagnosis of a disruptive behaviour or
dissocial disorder is not warranted if the disruptive behaviour is limited to symptomatic episodes
of another mental disorder (e.g. defiant and noncompliant behaviour during a depressive
episode), or if the behaviour is due to the effects of a substance or to another medical condition.
Disruptive behaviour and dissocial disorders are frequently associated with psychosocial
environments that include family dysfunction; problems with peers, co-workers and romantic
partners; and failure at school or work. Other psychosocial risk factors are common, such as
peer rejection, deviant peer-group influences and parental mental disorder. Behaviours that are
adaptive given the individual’s environmental circumstances (e.g. running away from an abusive
home; stealing in order to survive) should not be used as the sole basis for these diagnoses.
6C91
Disruptive behaviour and dissocial disorders
6C90.0 Oppositional defiant disorder, with chronic
irritability-anger
6C90.1 Oppositional defiant disorder, without chronic
irritability-anger
6C90.Z Oppositional defiant disorder, unspecified
Conduct-dissocial disorder
6C91.0 Conduct-dissocial disorder, childhood onset
6C91.1 Conduct-dissocial disorder, adolescent onset
6C91.Z Conduct-dissocial disorder, unspecified
Disruptive behaviour and dissocial disorders include the following:

18 - 6A21 Schizoaffective disorder
6A21 Schizoaffective disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
delusions. Auditory hallucinations (e.g. derogatory or accusatory voices that berate the individual for
imaginary weaknesses or sins) are more common than visual (e.g. visions of death or destruction) or
olfactory (e.g. the smell of rotting flesh) hallucinations. However, in a moderate or severe depressive
episode with psychotic symptoms, the psychotic symptoms are confined to the mood episode.
Schizophrenia is differentiated from depressive episodes in mood disorders by the occurrence of
psychotic and other symptoms that meet the diagnostic requirements of schizophrenia during
periods without mood symptoms that meet the diagnostic requirements of a moderate or severe
depressive episode. If the diagnostic requirements for both schizophrenia and a moderate or severe
depressive episode are met concurrently, and both the psychotic and mood symptoms last for at
least 1 month, schizoaffective disorder is the appropriate diagnosis.
Boundary with manic or mixed episodes in bipolar type I disorder
Psychotic symptoms may occur during manic or mixed episodes in bipolar type I disorder. Though
all types of psychotic symptoms are known to occur in manic or mixed episodes, grandiose delusions
(e.g. being chosen by God, having special powers or abilities) and persecutory and self-referential
delusions (e.g. being conspired against because of one’s special identity or abilities) are among
the most common. Experiences of influence, passivity or control (e.g. thought insertion, thought
withdrawal or thought broadcasting) may also occur during manic or mixed episodes. Hallucinations
are less frequent and commonly accompany delusions of persecution or reference. They are usually
auditory (e.g. adulatory voices), and less commonly visual (e.g. visions of deities), somatic or tactile.
However, in a manic or mixed episode with psychotic symptoms, the psychotic symptoms are
confined to the mood episode. Schizophrenia is differentiated from manic or mixed episodes in
bipolar type I disorder by the occurrence of psychotic and other symptoms that meet the diagnostic
requirements of schizophrenia during periods without mood symptoms that meet the diagnostic
requirements of a manic or mixed episode. If the diagnostic requirements for both schizophrenia
and bipolar type I disorder are met concurrently, and both psychotic and mood symptoms last for
at least 1 month, schizoaffective disorder is the appropriate diagnosis.
Boundary with post-traumatic stress disorder and complex post-traumatic
stress disorder
In post-traumatic stress disorder and complex post-traumatic stress disorder, severe flashbacks
that involve a complete loss of awareness of present surroundings may occur, intrusive images
or memories may have a hallucinatory quality, and hypervigilance may reach proportions that
appear to be paranoid. However, the diagnoses of post-traumatic stress disorder and complex
post-traumatic stress disorder require a history of exposure to an event or series of events (either
short- or long-lasting) of an extremely threatening or horrific nature. These diagnoses also require
re-experiencing of the traumatic event in the present, in which the event is not just remembered but
rather experienced as occurring again in the here and now, and may include loss of awareness and
hallucination-like experiences within this specific context. Re-experiencing of traumatic events is not
a characteristic feature of schizophrenia. However, post-traumatic stress disorder and schizophrenia
frequently co-occur, and both diagnoses should be assigned when the diagnostic requirements for
each are met.
Schizoaffective disorder
Essential (required) features
• All diagnostic requirements for schizophrenia are met concurrently with mood symptoms
that meet the diagnostic requirements of a moderate or severe depressive episode, a manic
episode or a mixed episode.
6A21
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder
171
Schizophrenia and other primary psychotic disorders
Note: in making a diagnosis of schizoaffective disorder, depressive episodes must include
depressed mood, not just diminished interest or pleasure.
• The onsets of the psychotic and mood symptoms are either simultaneous or occur within
a few days of one another.
• The duration of symptomatic episodes is at least 1 month for both psychotic and mood
symptoms.
• The symptoms or behaviours are not a manifestation of another medical condition (e.g. a
brain tumour), and are not due to the effects of a substance or medication on the central
nervous system (e.g. corticosteroids), including withdrawal effects (e.g. from alcohol).
Course specifiers for schizoaffective disorder
The following specifiers should be applied to identify the course of schizoaffective disorder,
including whether the individual currently meets the diagnostic requirements of schizoaffective
disorder or is in partial or full remission. Course specifiers are also used to indicate whether the
current episode is the first episode of schizoaffective disorder, whether there have been multiple
such episodes, or whether symptoms have been continuous over an extended period of time.
Schizoaffective disorder, first episode
• The first episode specifier should be applied when the current or most recent episode is the
first manifestation of the schizoaffective disorder meeting all diagnostic requirements in
terms of symptoms and duration. If there has been a previous episode of schizoaffective
disorder or schizophrenia, the multiple episodes specifier should be applied.
Schizoaffective disorder, first episode, currently symptomatic
• All diagnostic requirements for schizoaffective disorder in terms of symptoms and duration
are currently met, or have been met within the past month.
• There have been no previous episodes of schizophrenia or schizoaffective disorder.
Note: if the duration of the episode is more than 1 year, the continuous specifier may be used
instead, depending on the clinical situation.
Schizoaffective disorder, first episode, in partial remission
• The full diagnostic requirements for schizoaffective disorder have not been met within the
past month, but some clinically significant symptoms remain, which may or may not be
associated with functional impairment.
• There have been no previous episodes of schizophrenia or schizoaffective disorder.
6A21.0
6A21.00
6A21.01
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Note: this category may also be used to designate the re-emergence of subthreshold symptoms of
schizoaffective disorder following an asymptomatic period in a person who has previously met
the diagnostic requirements for schizoaffective disorder.
Schizoaffective disorder, first episode, in full remission
• The full diagnostic requirements for schizoaffective disorder have not been met within the
past month, and no clinically significant symptoms remain.
• There have been no previous episodes of schizophrenia or schizoaffective disorder.
Schizoaffective disorder, first episode, unspecified
Schizoaffective disorder, multiple episodes
• The multiple episodes specifier should be applied when there have been a minimum of two
episodes meeting all diagnostic requirements of schizoaffective disorder or schizophrenia
in terms of symptoms, with a period of partial or full remission between episodes lasting
at least 3 months, and the current or most recent episode is schizoaffective disorder. Note
that the 1-month duration requirement for the first episode does not necessarily need to be
met for subsequent episodes. During the period of remission, the diagnostic requirements
of schizoaffective disorder are either only partially fulfilled or absent.
Schizoaffective disorder, multiple episodes, currently symptomatic
• All symptom requirements for schizoaffective disorder are currently met, or have been met
within the past month. Note that the 1-month duration requirement for the first episode
does not necessarily need to be met for subsequent episodes.
• There have been a minimum of two episodes of schizoaffective disorder or a previous
episode of schizophrenia, with a period of partial or full remission between episodes
lasting at least 3 months.
Schizoaffective disorder, multiple episodes, in partial remission
• The full diagnostic requirements for schizoaffective disorder have not been met within the
past month, but some clinically significant symptoms remain, which may or may not be
associated with functional impairment.
• There have been a minimum of two episodes of schizoaffective disorder or a previous
episode of schizophrenia, with a period of partial or full remission between episodes
lasting at least 3 months.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms of
schizoaffective disorder following an asymptomatic period.
6A21.02
6A21.0Z
6A21.1
6A21.10
6A21.11
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder
173
Schizophrenia and other primary psychotic disorders
Schizoaffective disorder, multiple episodes, in full remission
• The full diagnostic requirements for schizoaffective disorder have not been met within the
past month, and no clinically significant symptoms remain.
• There have been a minimum of two episodes of schizoaffective disorder or a previous
episode of schizophrenia, with a period of partial or full remission between episodes
lasting at least 3 months.
Schizoaffective disorder, multiple episodes, unspecified
Schizoaffective disorder, continuous
• The continuous specifier should be applied when symptoms fulfilling all diagnostic
requirements of schizoaffective disorder have been present for almost all of the course of
the disorder during the person’s lifetime since its first onset, with periods of subthreshold
symptoms being very brief relative to the overall course. In order to apply this specifier to a
first episode, the duration of schizoaffective disorder should be at least 1 year. In that case,
the continuous specifier should be applied instead of the first episode specifier.
Schizoaffective disorder, continuous, currently symptomatic
• All symptom requirements for schizoaffective disorder are currently met, or have been met
within the past month.
• Symptoms meeting the diagnostic requirements for schizoaffective disorder or
schizophrenia have been present for almost all of the course of the disorder during the
person’s lifetime since its first onset.
• Periods of partial or full remission have been very brief relative to the overall course, and
none have lasted for three months or longer.
• To apply the continuous specifier to a first episode, symptoms meeting the diagnostic
requirements for schizoaffective disorder must have been present for at least 1 year.
Schizoaffective disorder, continuous, in partial remission
• The full diagnostic requirements for schizoaffective disorder, continuous were previously
met but have not been met within the past month.
• Some clinically significant symptoms of schizoaffective disorder remain, which may or
may not be associated with functional impairment.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms of
schizoaffective disorder following an asymptomatic period.
6A21.1Z
6A21.2
6A21.20
6A21.21
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder
6A21.12
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Schizoaffective disorder, continuous, in full remission
• The full diagnostic requirements for schizoaffective disorder, continuous were previously
met but have not been met within the past month.
• No clinically significant symptoms of schizoaffective disorder remain.
Schizoaffective disorder, continuous, unspecified
Other specified schizoaffective disorder
Schizoaffective disorder, unspecified
Additional clinical features
• The onset of schizoaffective disorder may be acute, with serious disturbance apparent
within a few days, or insidious, with a gradual development of signs and symptoms.
• There is often a history of prior mood episodes and a previous diagnosis of a depressive
disorder or a bipolar disorder in individuals with schizoaffective disorder.
• A prodromal phase often precedes the onset of psychotic symptoms by weeks or months.
The characteristic features of this phase often include loss of interest in work or social
activities, neglect of personal appearance or hygiene, inversion of the sleep cycle and
attenuated psychotic symptoms, accompanied by negative symptoms, anxiety/agitation or
varying degrees of depressive symptoms.
• An episodic course with periods of remission is the most common pattern of progression
of the disorder.
• Schizoaffective disorder is frequently associated with significant distress and significant
impairment in personal, family, social, educational, occupational or other important areas
of functioning. However, distress and psychosocial impairment are not requirements for a
diagnosis of schizoaffective disorder.
Boundary with normality (threshold)
• Psychotic-like symptoms or unusual subjective experiences may occur in the general
population, but these are usually fleeting in nature and are not accompanied by other
symptoms of schizophrenia or a deterioration in psychosocial functioning. In schizoaffective
6A21.2Z
6A21.Y
6A21.Z
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder
6A21.22
175
Schizophrenia and other primary psychotic disorders
disorder, multiple persistent symptoms are present, and are typically accompanied by
impairment in cognitive functioning and other psychosocial problems.
Course features
• Some people with schizoaffective disorder experience exacerbations and remission of
symptoms periodically throughout the illness course, whereas others experience a full
remission of symptoms between episodes.
Developmental presentations
• Diagnosis of schizoaffective disorder among children is challenging because the sequence
of mood and psychotic symptoms may be difficult for children to describe accurately.
• Children who are diagnosed with schizoaffective disorder are the most severely impaired
and have the poorest outcomes among all children diagnosed with psychotic disorders.
• Schizoaffective disorder with manic episodes is more common among young adults whereas
schizoaffective disorder with depressive episodes is more common among older adults.
Culture-related features
• See the culture-related features section for schizophrenia, all of which also applies to
schizoaffective disorder.
• In addition. culture may affect the expression of mood symptoms, the use of idioms of
distress and illness-related metaphors, and the prominence of certain patterns of moodrelated symptoms. For example, religious or spiritual views about suicidal ideation or
behaviour may decrease reporting and increase associated guilt; and shame may be more
prominent than guilt in sociocentric societies. Norms for experiencing and articulating
mood symptoms psychologically vary by culture, as does the attribution of distress to
interpersonal, social, psychological, biological, supernatural or spiritual concerns.
• Bodily complaints as somatic expressions of depression may predominate over cognitive
mood symptoms due to their greater cultural acceptability as indications of the need for
clinical attention.
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Schizoaffective disorder is more prevalent among females – especially schizoaffective
disorder with depressive episodes.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizophrenia
The diagnoses of schizophrenia and schizoaffective disorder are intended to apply to the current
or most recent episode of the disorder. In other words, a previous diagnosis of schizoaffective
disorder does not preclude a diagnosis of schizophrenia, and vice versa. In both schizophrenia and
schizoaffective disorder, at least two the characteristic symptoms of schizophrenia are present most of
the time for a period of 1 month or more. In schizoaffective disorder, the symptoms of schizophrenia
are present concurrently with mood symptoms that meet the full diagnostic requirements of a
mood episode and last for at least 1 month, and the onsets of the psychotic and mood symptoms
are either simultaneous or occur within a few days of one another. In schizophrenia, co-occurring
mood symptoms, if any, either do not persist for as long as 1 month or are not of sufficient severity
to meet the requirements of a moderate or severe depressive episode, a manic episode or a mixed
episode. (See mood episode descriptions, p. 212.) An episode that initially meets the diagnostic
requirements for schizoaffective disorder in which only the mood symptoms remit, so that the
duration of psychotic symptoms without mood symptoms is much longer than the duration of
concurrent symptoms, may be best characterized as an episode of schizophrenia.
Boundary with mood episodes with psychotic symptoms
Schizoaffective disorder, schizophrenia, moderate or severe depressive episodes, manic episodes and
mixed episodes are all intended to describe the current episode of the disorder. In schizoaffective
disorder, the duration and symptom requirements for schizophrenia are fully met during the mood
episode. In a depressive disorder with psychotic symptoms or a bipolar type I disorder with psychotic
symptoms, psychotic symptoms occur simultaneously with the mood episodes but do not meet
the diagnostic requirements for schizophrenia (e.g. hallucinations without any other psychotic
symptoms). It is possible for an individual to meet the diagnostic requirements for each during
different periods.
Boundary with acute and transient psychotic disorder
In schizoaffective disorder, the psychotic symptoms persist for at least 1 month in their full,
florid form. In contrast, in acute and transient psychotic disorder, the symptom requirements for
schizophrenia or a depressive, manic or mixed episode are not met. Moreover, the symptoms in
acute and transient psychotic disorder tend to fluctuate rapidly in intensity and type across time,
such that the content and focus of delusions or hallucinations often shift, even on a daily basis.
Negative symptoms may be present in schizoaffective disorder, but do not occur in acute transient
psychotic disorder. The duration of acute and transient psychotic disorder does not exceed 3 months,
and most often lasts from a few days to 1 month, compared to a much longer typical course for
schizoaffective disorder.
Schizophrenia and other primary psychotic disorders | Schizoaffective disorder

180 - 6C90 Oppositional defiant disorder
6C90 Oppositional defiant disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
In addition, the following specifiers may be applied to all disorders in the disruptive behaviour
and dissocial disorders grouping, where x corresponds to the fourth character of the disorder
code and y corresponds to the fifth character:
With limited prosocial emotions
With typical prosocial emotions
Unspecified
Oppositional defiant disorder
Essential (required) features
• A pattern of markedly noncompliant, defiant and disobedient behaviour that is atypical
for individuals of comparable age, developmental level, gender and sociocultural context
is required for diagnosis. The pattern of behaviour may include:
• persistent difficulty getting along with others (e.g. arguing with authority figures; actively
defying or refusing to comply with requests, directives or rules; deliberately annoying
others; blaming peers or co-workers for mistakes or misbehaviour);
• provocative, spiteful or vindictive behaviour (e.g. antagonizing others, using social media
to attack or mock others);
• extreme irritability or anger (e.g. being touchy or easily annoyed, losing temper, angry
outbursts, being angry and resentful).
• The behaviour pattern has persisted for an extended period of time (e.g. 6 months or more).
• The oppositional behaviours are not better accounted for by relational problems between
the individual and a particular authority figure towards whom the individual is behaving
in a defiant manner. Examples may include parents, teachers or supervisors who act
antagonistically or place unreasonable demands on the individual.
• The behaviour pattern results in significant impairment in personal, family, social,
educational or other important areas of functioning.
6C90
Disruptive behaviour and dissocial disorders | Oppositional defiant disorder
6C9Y
Other specified disruptive behaviour or dissocial disorder
6C9Z
Disruptive behaviour or dissocial disorder, unspecified.
6C9x.y0
6C9x.y1
6C9x.yZ
539
Disruptive behaviour and dissocial disorders
Specifiers for the presence or absence of chronic irritability-anger
Two specifiers indicating the presence or absence of chronic irritability-anger can be assigned
to the diagnosis of oppositional defiant disorder.
Oppositional defiant disorder, with chronic irritability-anger
• All diagnostic requirements for oppositional defiant disorder are met.
• The presentation is characterized by prevailing, persistent irritable mood or anger that is
atypical for individuals of comparable age, developmental level, gender and sociocultural
context, including most of the following features:
• often feeling angry or resentful, showing bitterness towards others, or feeling as if things
are unfair;
• often being touchy or easily annoyed, exhibiting oversensitivity or irritation to minimal
or perceived provocations;
• often losing temper, exhibiting angry verbal or behavioural outbursts – which may include
tantrums, destructive behaviours or other forms of severe mood dysregulation.
• The anger or resentment, touchiness or annoyance, and loss of temper is out of proportion
in intensity or duration to any provocation, and may be present independent of any
apparent provocation.
• Chronic irritability-anger is characteristic of the individual’s functioning nearly every day,
are not limited to discrete periods, is observable across multiple settings or domains of
functioning (e.g. home, school, social relationships), and is not restricted to the individual’s
relationship with their parents or guardians.
• The pattern of chronic irritability-anger is not better accounted for by another mental
disorder (e.g. irritable mood in the context of manic or depressive episodes).
• Individuals with this subtype usually also display other characteristic features of
oppositional defiant disorder, including defiant, headstrong or vindictive behaviours.
Oppositional defiant disorder, without chronic irritability-anger
• All diagnostic requirements for oppositional defiant disorder are met.
• The presentation is characterized by absence of prevailing, persistently angry or irritable
mood. In these individuals, anger and irritability occur less frequently, and tend to be
transitory, less severe and less often out of proportion to the provocation compared to
individuals with chronic irritability-anger.
Oppositional defiant disorder, unspecified
6C90.0
6C90.1
6C90.Z
Disruptive behaviour and dissocial disorders | Oppositional defiant disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Although often identified through parental report of noncompliant behaviour, the negative
and antagonistic aspects of oppositional defiant disorder also exert a broader negative
influence on interactions with others outside the family. Oppositional defiant disorder is
associated with peer rejection and interpersonal discord through the school years and into
adulthood.
• Frequently, the oppositional defiant features have a provocative quality, such that
individuals initiate confrontations and may be seen as excessively rude and uncooperative.
• Younger children (e.g. 3–5 years of age) are typically more closely supervised, and receive
frequent instructions and limits imposed on them by authority figures (e.g. parents or
other guardians, caregivers, teachers). As children grow older, direct demands by authority
figures typically become less frequent. Moreover, others interacting with children or
adolescents with oppositional defiant disorder may come to avoid placing demands on
them due to their negative response. Therefore, a diagnosis is not precluded because
oppositional or defiant behaviours occur relatively infrequently, as long as they characterize
most interactions with authority figures.
• Adults with oppositional defiant disorder continue to experience conflictual relationships
with parents and family members, and have generally poorer social support networks.
This affects the number and quality of their friendships and romantic relationships. They
typically struggle to function in the workplace due to difficulties in their interactions with
supervisors and co-workers.
• Features of irritability and anger (e.g. being touchy or easily annoyed, losing temper,
being angry and resentful) are sometimes the predominant characteristics of the clinical
presentation. However, irritability and anger alone are neither necessary nor sufficient
for the diagnosis. These symptoms must be accompanied by a pattern of markedly
noncompliant, defiant and disobedient behaviour that is atypical for individuals of
comparable age and developmental level. The presence of chronic irritability-anger is
indicated using the corresponding specifier.
• Oppositional defiant disorder with chronic irritability-anger is not necessarily more
severe or rare than oppositional defiant disorder without chronic irritability-anger. Rather,
oppositional defiant disorder with chronic irritability-anger identifies a pattern of mood
dysregulation that can range in severity from frequent and impairing tantrums to extreme
presentations of the mood dysregulation.
• Individuals with oppositional defiant disorder may present with limited prosocial
emotions. When assessing for oppositional defiant disorder, the clinician should also assess
for limited prosocial emotions; if present, the appropriate specifier should be assigned (see
p. 548). Individuals with oppositional defiant disorder with limited prosocial emotions are
more likely to exhibit a more persistent and severe pattern of antisocial behaviour that may
subsequently meet the diagnostic requirements for conduct-dissocial disorder.
• Oppositional defiant disorder in childhood frequently co-occurs with attention deficit
hyperactivity disorder, conduct-dissocial disorder, and internalizing disorders such as
depressive disorders or anxiety and fear-related disorders.
Disruptive behaviour and dissocial disorders | Oppositional defiant disorder
541
Disruptive behaviour and dissocial disorders
Boundary with normality (threshold)
• Transient noncompliance, defiance and disobedience including irritability or anger can
occur within the normal range of behaviour as a part of typical development, or in response
to increased demands on the developing child or changes in the child’s environment
(e.g. transition to a new school or city), or as a manifestation of normative anxiety in the
context of specific tasks or situations (e.g. going to school and separating from parents
for the first time). The presence of such behaviours should not be taken as evidence for
a presumptive diagnosis of oppositional defiant disorder. Oppositional defiant disorder
should only be diagnosed when there is a persistent pattern of markedly noncompliant,
defiant and disobedient behaviour that is atypical considering the individual’s age, gender
and sociocultural context.
Course features
• The heterogeneity of presentations in oppositional defiant disorder has meaningful clinical
and prognostic implications. Oppositional defiant disorder can be a developmental
precursor for the development of conduct-dissocial disorder, especially when the
presentation of oppositional defiant disorder includes severely defiant or spiteful/
vindictive behaviours. However, many children with oppositional defiant disorder do not
subsequently develop conduct-dissocial disorder.
• A diagnosis of oppositional defiant disorder with chronic irritability-anger is associated
with the subsequent development of depressive disorders and anxiety and
fear-related disorders.
Developmental presentations
• Typical age of onset of oppositional defiant disorder is in middle childhood, with initial
symptoms typically appearing at preschool age. Symptoms rarely emerge for the first time
later than early adolescence.
• Prevalence rates of oppositional defiant disorder are estimated at 3.3% among children
and adolescents (aged 6–18 years). Some evidence suggests that overall prevalence of
oppositional defiant disorder decreases beginning in adolescence and young adulthood.
• Oppositional defiant disorder is more common among children and adolescents whose
families have experienced substantial disruptions in caregiving relationships, or in which
parenting practices tend to be harsh, inconsistent or neglectful.
• Although oppositional and argumentative behaviours are common in typically developing
children, unlike in oppositional defiant disorder, these behaviours tend to be transient and
do not consistently negatively affect the child’s functioning and development.
Disruptive behaviour and dissocial disorders | Oppositional defiant disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Oppositional defiant disorder has been associated with greater peer rejection, heightened
interpersonal conflict, and increased risk of co-occurring and subsequent difficulties in
adjustment throughout childhood and adulthood.
Culture-related features
• There is substantial variation in the prevalence of oppositional defiant disorder across
cultures. These differences may be related to cultural norms regarding uncooperative or
defiant behaviour in children. For example, cultures that value obedience highly may
have a lower threshold for considering a child’s behaviour to be noncompliant, defiant
or disobedient. The behaviours relevant to assigning a diagnosis of oppositional defiant
disorder should be evaluated in relation to social, cultural and subgroup norms.
• Variation in the prevalence of oppositional defiant disorder and conduct-dissocial disorder
across cultural groups may be related to differences in family structure and behaviour.
Lower prevalence may be associated with stricter disciplinary practices at home, strong
emphasis on educational or occupational attainment, and cultural values that disapprove
of an antisocial lifestyle.
Sex- and/or gender-related features
• Prevalence of oppositional defiant disorder is higher among school-aged boys than schoolaged girls, but does not appear to differ by gender at other points across the lifespan.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with conduct-dissocial disorder
The behaviour problems associated with oppositional defiant disorder are largely characterized by
interpersonal conflict with authority figures and difficulty getting along with others. In contrast,
conduct-dissocial disorder is characterized by a repetitive and persistent pattern of more severe
and dissocial behaviour, in which the basic rights of others or major age-appropriate social or
cultural norms, rules or laws are violated (e.g. aggression towards people or animals, destruction
of property, deceitfulness or theft, serious violations of rules). However, individuals with conductdissocial disorder often demonstrate a range or history of behaviour problems that may include
the interpersonal difficulties characteristic of oppositional defiant disorder. Both diagnoses may
be assigned if the full diagnostic requirements for each are met.
Boundary with attention deficit hyperactivity disorder
Individuals with attention deficit hyperactivity disorder often have difficulty following directions,
complying with rules and getting along with others. When these disruptive behaviours are
Disruptive behaviour and dissocial disorders | Oppositional defiant disorder
543
Disruptive behaviour and dissocial disorders
better accounted for by inattention or hyperactivity-impulsivity (e.g. failure to follow long and
complicated directions, difficulty remaining seated or staying on task when asked), oppositional
defiant disorder should not be diagnosed. In oppositional defiant disorder, the pattern of
noncompliance is characterized by disobedience, beyond problems with attention and behavioural
inhibition. However, attention deficit hyperactivity disorder and oppositional defiant disorder
commonly co-occur and both diagnoses may be assigned if the full diagnostic requirements for
each are met.
Boundary with autism spectrum disorder
Noncompliant and other disruptive behaviours characteristic of oppositional defiant disorder
should be distinguished from behaviour problems that are common among individuals with
autism spectrum disorder. The key difference is that, in autism spectrum disorder, disruptive
behaviours are often associated with specific environmental factors (e.g. sudden change in routine,
aversive sensory stimulation), or the noncompliance is a consequence of the core symptoms of
that disorder (e.g. social communication deficits, restricted, repetitive, inflexible patterns of
behaviour, sensory sensitivities) rather than reflecting an intention to be provocative or spiteful.
Individuals with oppositional defiant disorder do not typically exhibit the social communication
deficits and restricted, repetitive and inflexible patterns of behaviour, interests or activities that
are characteristic of autism spectrum disorder.
Boundary with mood disorders
It is common – particularly in children and adolescents – for patterns of noncompliance and
symptoms of irritability/anger to occur as a feature of a mood episode. Specifically, noncompliance
may result from a number of depressive symptoms (e.g. diminished interest or pleasure in
activities, difficulty concentrating, hopelessness, psychomotor retardation, reduced energy).
During manic, mixed or hypomanic episodes, individuals are less likely to follow rules and
comply with directions. Moreover, in children and adolescents, depressive, manic or hypomanic
mood can manifest as irritability. When the behaviour problems occur entirely in the context of
mood episodes, a separate diagnosis of oppositional defiant disorder should not be assigned.
Boundary with anxiety and fear-related disorders
In children and adolescents, symptoms of anxiety and fear-related disorders can sometimes
manifest as noncompliance, defiance and disobedience, including irritability or anger. For
example, children may exhibit angry outbursts and refuse to comply with requests when
presented with a task or a situation that makes them feel anxious (e.g. when a child with social
anxiety disorder is asked to make a presentation in class). These behaviours are typically a
manifestation of a desire on the part of the child or adolescent to avoid the feared situation or
stimulus. Furthermore, children and adolescents with anxiety and fear-related disorders do not
typically exhibit provocative, spiteful or vindictive behaviour. If the defiant behaviour occurs only
in response to situations or stimuli that elicit anxiety, fear or panic, oppositional defiant disorder
should not be diagnosed.
Boundary with intermittent explosive disorder
Regularly occurring severe temper outbursts that are grossly out of proportion in intensity or
duration to the provocation are the core symptom of intermittent explosive disorder but may also
occur in the context of oppositional defiant disorder with chronic irritability-anger. Individuals
with oppositional defiant disorder with chronic irritability-anger typically display other features
of oppositional defiant disorder, including defiant, headstrong or vindictive behaviours, which
are not characteristic of intermittent explosive disorder. In addition, individuals with intermittent
explosive disorder are more likely to exhibit significant physical aggression.
Disruptive behaviour and dissocial disorders | Oppositional defiant disorder

181 - 6C91 Conduct dissocial disorder
6C91 Conduct-dissocial disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Conduct-dissocial disorder
Essential (required) features
• A repetitive and persistent pattern of behaviour in which the basic rights of others or major
age-appropriate social or cultural norms, rules or laws are violated is required for diagnosis.
Typically, multiple behaviours are involved, including one or more of the following:
• aggression towards people or animals, such as bullying, threatening or intimidating others,
instigating physical fights, using weapons that can cause serious physical harm to others
(such as a brick, broken bottle, knife or gun), physical cruelty to people, physical cruelty
to animals, aggressive forms of stealing (e.g. mugging, purse snatching, extortion), or
forcing someone into sexual activity;
• destruction of property, such as deliberate fire setting with the intention of causing serious
damage or deliberate destruction of others’ property (e.g. purposely breaking other
children’s toys, breaking windows, scratching cars, slashing tires);
• deceitfulness or theft, such as stealing items of value (e.g. shoplifting, forgery), lying to
obtain goods or favours or to avoid obligations (e.g. “conning” others), or breaking into
someone’s house, building or car;
• serious violations of rules, such as children or adolescents repeatedly staying out all night
despite parental prohibitions, repeatedly running away from home, or often skipping
school or work without permission.
• The pattern of behaviour must be persistent and recurrent, including multiple incidents
of the types of behaviours described above over an extended period of time (e.g. at least
1 year). The mere commission of one or more delinquent acts is not sufficient for the
diagnosis.
• The behaviour pattern results in significant impairment in personal, family, social,
educational, occupational or other important areas of functioning.
Specifiers for age of onset
Two subtypes related to age of onset can be specified in individuals who meet the diagnostic
requirements for conduct-dissocial disorder.
Conduct-dissocial disorder, childhood onset
• All diagnostic requirements for conduct-dissocial disorder are met.
• One or more features of the disorder have clearly been present and persistent during
childhood prior to adolescence (e.g. before 10 years of age).
6C91
6C91.0
Disruptive behaviour and dissocial disorders | Conduct-dissocial disorder
545
Disruptive behaviour and dissocial disorders
Conduct-dissocial disorder, adolescent onset
• All diagnostic requirements for conduct-dissocial disorder are met.
• None of the features of the disorder were present prior to adolescence (e.g. before 10 years
of age).
Conduct-dissocial disorder, unspecified
Additional clinical features
• Individuals with conduct-dissocial disorder may be part of a delinquent peer group where
delinquent activities are often conducted in association with peers. This may be particularly
common among those with adolescent onset.
• The relationship between conduct-dissocial disorder and oppositional defiant disorder has
historically been conceptualized as hierarchical and developmental in nature, with conductdissocial disorder generally considered more severe than, and commonly preceded by,
oppositional defiant disorder. However, conduct-dissocial disorder frequently co-occurs
and can be diagnosed with oppositional defiant disorder, particularly among individuals
with a more persistent history of behaviour problems.
• Individuals with conduct-dissocial disorder with limited prosocial emotions (see
p. 548) and individuals with conduct-dissocial disorder, childhood onset, are at greater
risk of exhibiting a more persistent and severe pattern of antisocial behaviour over time.
However, the subtypes for age of onset and the specifier for prosocial emotions are distinct
characteristics that should be considered separately. In particular, childhood onset does
not necessarily indicate that the individual will exhibit limited prosocial emotions.
• Conduct-dissocial disorder frequently co-occurs with attention deficit hyperactivity
disorder, developmental learning disorder, anxiety and fear-related disorders, mood
disorders, and disorders due to substance use.
Boundary with normality (threshold)
• Engaging in political protests should not be regarded as indicating the presence of conductdissocial disorder.
• The behaviours that contribute to a diagnosis of conduct-dissocial disorder can include
criminal offences, and may entail legal or disciplinary repercussions – particularly for
adolescents and adults. At the same time, many individuals who commit such criminal
offences do not exhibit a persistent and recurrent pattern of antisocial behaviour in which
the basic rights of others or major age-appropriate social or cultural norms, rules or laws
are violated. Criminal behaviours may occur impulsively or opportunistically, or in relation
Disruptive behaviour and dissocial disorders | Conduct-dissocial disorder
6C91.1
6C91.Z
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
to substance use or intoxication. Clinical assessment and diagnosis should focus on the
broader pattern of behaviour rather than solely on the criminality of specific behaviours
or incidents.
Course features
• Earlier age of onset and greater symptom severity are predictive of worse prognosis, with
these individuals more likely to engage in criminal behaviour and substance abuse, and
to experience additional co-occurring mental and behavioural disorder diagnoses during
adulthood.
• The course of conduct-dissocial disorder is highly variable, with some individuals
experiencing a full remission of symptoms by adulthood. Initial symptoms of conductdissocial disorder are typically less severe in form (e.g. lying), but may progress in their
severity over time (e.g. assault). There are significant individual differences in course
features and progression of symptoms over time.
• When conduct-dissocial disorder is present in adulthood, it has generally been preceded
by a history of serious behaviour problems during childhood and adolescence.
• The persistence of conduct-dissocial disorder into adulthood is often marked by continuity
in types of behaviour problems (e.g. property violations in contrast to theft). Individuals
with conduct-dissocial disorder who are violent during adolescence typically continue
to engage in more frequent violence than their peers in adulthood. Status offences (e.g.
running away, truancy) are less relevant in adulthood, but are a risk factor for continuing
rule-breaking behaviour and criminal arrest.
Developmental presentations
• Although onset of conduct-dissocial disorder can occur in early childhood during the
preschool years, typical age of onset is during early to middle adolescence. Onset of
conduct-dissocial disorder is rare after the age of 16 years.
Culture-related features
• Assessment of conduct problems should account for contextual factors to determine
whether a diagnosis is appropriate. In some cultural settings, for example, school-aged
children may be away from school for long periods of seasonal employment rather than for
conduct reasons. Alternatively, in communities with high levels of organized violence (e.g.
gangs) or in the midst of civil conflict or war (e.g. where children as recruited as soldiers),
children may be coerced into participating in interpersonal violence or property theft,
which they may carry out for their own survival. A diagnosis of conduct-dissocial disorder
should not be assigned in such cases.
Disruptive behaviour and dissocial disorders | Conduct-dissocial disorder
547
Disruptive behaviour and dissocial disorders
• Conduct-dissocial disorder in adolescents often co-occurs with disorders due to substance
use – especially those associated with use of alcohol. The rates of co-occurrence are
influenced by sociocultural variation in availability of substances.
Sex- and/or gender-related features
• Conduct-dissocial disorder is more common among males.
• Males with conduct-dissocial disorder are more likely to exhibit symptoms of stealing,
vandalism, fighting and school discipline problems, whereas females are more likely to
exhibit lying, truancy, substance abuse, absconding and prostitution.
• Males with conduct-dissocial disorder more commonly exhibit both physical and relational
aggression, whereas females are more likely to exclusively exhibit relational aggression.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with oppositional defiant disorder
For a diagnosis of conduct-dissocial disorder to be assigned, the pattern of behaviour must be
severe and dissocial (i.e. violating major rules, norms, or the rights of others), such that it extends
beyond the noncompliant and defiant behaviours that are characteristic of oppositional defiant
disorder. However, oppositional defiant disorder and conduct-dissocial disorder frequently cooccur, particularly among adolescents and individuals with a more persistent history of behaviour
problems, and may be diagnosed together if the full diagnostic requirements for each are met.
Boundary with attention deficit hyperactivity disorder
Individuals with attention deficit hyperactivity disorder may exhibit disruptive behaviours as a
result of their impulsivity or hyperactivity; however, these disruptive behaviours are not typically
severe and dissocial in nature (i.e. they do not violate major rules, norms or the rights of others),
and therefore would not warrant an additional diagnosis of conduct-dissocial disorder. However,
conduct-dissocial disorder and attention deficit hyperactivity disorder can co-occur, and both
may be diagnosed if the full diagnostic requirements for each are met.
Boundary with mood disorders
Conduct problems, aggressive behaviours, risky behaviours and irritability/anger can occur in
the context of mood episodes (depressive, manic, mixed or hypomanic). Moreover, in children
and adolescents, depressive, manic or hypomanic mood can manifest as irritability. When the
behaviour problems occur entirely in the context of mood episodes, a separate diagnosis of
conduct-dissocial disorder is generally not warranted.
Boundary with intermittent explosive disorder
Individuals with intermittent explosive disorder may come into conflict with other people and
the law because of their explosive outbursts, but these episodes do not constitute a more general
pattern of antisocial behaviour characteristic of conduct-dissocial disorder (e.g. rule violations,
Disruptive behaviour and dissocial disorders | Conduct-dissocial disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
lying, theft). In addition, intermittent explosive disorder is characterized by impulsive aggression,
while aggression in conduct-dissocial disorder is often premeditated and instrumental.
Boundary with personality disorder
Conduct-dissocial disorder is not a personality disorder, although it is related to specific personality
disorder categories in the clinical and research nomenclature (i.e. dissocial personality disorder,
antisocial personality disorder). Personality disorder is characterized by a relatively enduring
and pervasive disturbance in how individuals experience and interpret themselves, others and
the world that results in maladaptive patterns of cognition, emotional experience, emotional
expression and behaviour. These maladaptive patterns lead to significant problems in psychosocial
functioning that are particularly evident in interpersonal relationships, manifested across a range
of personal and social situations (i.e. not limited to specific relationships or situations). Individuals
with personality disorder may have prominent dissocial features as an aspect of personality traits.
The diagnosis of conduct-dissocial disorder is made based on a recurrent pattern of antisocial
behaviour that may range in duration from a discrete period lasting a number of months to a
pattern that persists across the lifespan. Conduct-dissocial disorder and personality disorder can
co-occur, and both may be diagnosed if the full diagnostic requirements for each are met.
Boundary with disorders due to substance use
If the pattern of dissocial behaviour is limited to obtaining or using illicit substances, or if
the behaviour is exclusively related to the effects of intoxication, dependence or withdrawal,
conduct-dissocial disorder should not be diagnosed, and a disorder due to substance use should
be considered instead. At the same time, co-occurrence of episodes of dissocial behaviour and
substance use is common among individuals with conduct-dissocial disorder. This distinction may
therefore depend on a complex clinical judgement that takes into account the onset, sequencing
and context of the relevant behaviours. However, conduct-dissocial disorder and disorders due to
substance use frequently co-occur, and both may be diagnosed if the full diagnostic requirements
for each are met.
Specifier applicable to oppositional defiant disorder and conductdissocial disorder
Specifiers for limited or typical prosocial emotions
• The with limited prosocial emotions specifier may be applied to individuals who meet the
diagnostic requirements for oppositional defiant disorder or conduct-dissocial disorder
and also exhibit a pattern of limited prosocial emotions sometimes referred to as “callous
and unemotional traits”. Individuals with these characteristics represent a minority of those
with disruptive behaviour and dissocial disorders diagnoses. The with limited prosocial
emotions specifier represents a relatively more severe and less common presentation of
disruptive behaviour and dissocial disorders.
Disruptive behaviour and dissocial disorders | Conduct-dissocial disorder
549
Disruptive behaviour and dissocial disorders
In evaluating prosocial emotions, it is important to obtain information from others who have
known the individual for an extended period of time, in addition to the individual’s self-report of
their own behaviours and experience.
Limited or typical prosocial emotions in individuals with oppositional defiant disorder or
conduct-dissocial disorder can be specified as follows.
with limited prosocial emotions
• In the context of a diagnosis of disruptive behaviour and dissocial disorders, this specifier
represents the presence of a characteristic social-emotional pattern in which several of the
following features are repeatedly manifested:
• limited or absent empathy or sensitivity to others’ feelings or concern for their distress – the
individual is more concerned with how events and their own behaviours affect themselves
than with how they affect others, even if they cause harm;
• limited or absent remorse, shame or guilt over their own behaviour (unless prompted by
being apprehended), lack of concern about the consequences of their actions on others
and relative indifference towards the probability of punishment;
• limited or absent concern over poor/problematic performance in school, work or other
important activities – the individual putting forth little effort and blaming others for
their poor performance;
• limited or shallow expression of emotions, particularly positive or loving feelings towards
others – the individual’s emotional expression possibly appearing shallow, superficial,
insincere or instrumental.
• This pattern is pervasive across situations and relationships (i.e. the specifier should not
be applied based on a single characteristic, a single relationship or a single instance of
behaviour).
• The pattern is persistent over time (e.g. at least 1 year).
• Among individuals with oppositional defiant disorder, those with limited prosocial
emotions tend to display a particularly extreme and stable pattern of oppositional
behaviours.
• Among individuals with conduct-dissocial disorder, those with limited prosocial emotions
tend to display a particularly severe, aggressive and stable pattern of antisocial behaviours.
with typical prosocial emotions
• In the context of a diagnosis of disruptive behaviour and dissocial disorders, this specifier
represents a more common pattern of oppositional defiant disorder or conduct-dissocial
disorder that is not characterized by the features of limited prosocial emotions.
• Although some features similar to limited prosocial emotions (e.g. low concern, limited
remorse) may be evident at times, they are generally infrequent, transitory and less
pronounced, and do not represent a persistent pervasive pattern of social-emotional
deficits.
• Most individuals with disruptive behaviour and dissocial disorders exhibit typical
prosocial emotions.
6C9x.y0
6C9x.y1
Disruptive behaviour and dissocial disorders | Conduct-dissocial disorder

182 - 6C9Y Other specified disruptive behaviour or
6C9Y Other specified disruptive behaviour or dissocial disorder

183 - 6C9Z Disruptive behaviour or dissocial disord
6C9Z Disruptive behaviour or dissocial disorder, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
unspecified prosocial emotions
Other specified disruptive behaviour or dissocial disorder
Essential (required) features
• The presentation is characterized by disruptive or dissocial symptoms that share primary
clinical features with other disruptive behaviour and dissocial disorders (i.e. persistent
behaviour problems across multiple settings that range from markedly and persistently
defiant, disobedient, provocative or spiteful to those that persistently violate the basic
rights of others or major age-appropriate societal norms, rules or laws).
• The disruptive or dissocial symptoms do not fulfil the diagnostic requirements for
oppositional defiant disorder or conduct-dissocial disorder.
• The symptoms are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. attention deficit hyperactivity disorder, a mood
disorder, an anxiety or fear-related disorder).
• The behaviour pattern has persisted for an extended period of time (e.g. 6 months or more).
• The symptoms and behaviours are not developmentally appropriate or culturally
sanctioned.
• The symptoms and behaviours are not a manifestation of another medical condition, and
are not due to the effects of a substance or medication on the central nervous system,
including withdrawal effects.
• The symptoms result in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning.
Disruptive behaviour or dissocial disorder, unspecified
6C9Y
6C9Z
Disruptive behaviour and dissocial disorders | Other specified disruptive behaviour or dissocial disorder
6C9x.yZ
551
Disruptive behaviour and dissocial disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

184 - Personality disorders and related traits
Personality disorders and related traits
553
Personality disorders and related traits
6D10.0
Personality disorders and
related traits
Mild personality disorder.
Personality refers to an individual’s characteristic way of behaving and experiencing life, and of
perceiving and interpreting themselves, other people, events and situations. Personality disorder
is a marked disturbance in personality functioning, which is nearly always associated with
considerable personal and social disruption. The central manifestations of personality disorder
are impairments in functioning of aspects of the self (e.g. identity, self-worth, capacity for
self-direction) and/or problems in interpersonal functioning (e.g. developing and maintaining
close and mutually satisfying relationships, understanding others’ perspectives, managing
conflict in relationships). Impairments in self-functioning and/or interpersonal functioning are
manifested in maladaptive (e.g. inflexible or poorly regulated) patterns of cognition, emotional
experience, emotional expression and behaviour.
The following diagnostic requirements for personality disorder first present a set of essential
features, all of which must be present to diagnose a personality disorder. Once the diagnosis of a
personality disorder has been established, it should be described in terms of its level of severity:
Moderate personality disorder.
Severe personality disorder.
Personality disorder, severity unspecified.
Also listed in this grouping is:
QE50.7
Personality difficulty
Personality difficulty is not classified as a mental disorder but rather is listed in the grouping of
problems associated with interpersonal interactions in Chapter 24 on factors influencing health
status or contact with health services.
Personality disorder and personality difficulty can be further described using five trait domain
specifiers. These describe the characteristics of the individual’s personality that are most prominent
and that contribute to personality disturbance. As many as necessary to describe personality
functioning should be applied.
6D10.1
6D10.2
6D10.Z
Personality disorders and related traits

185 - General diagnostic requirements for personali
General diagnostic requirements for personality disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Trait domain specifiers that may be recorded include the following:
6D11.0
Negative affectivity
Detachment
Dissociality
Disinhibition
Anankastia
More detailed guidance about the personality characteristics reflected in the trait domain
specifiers is provided in the following sections.
Clinicians may also wish to add an additional specifier:
Borderline pattern
The borderline pattern specifier has been included to enhance the clinical utility of the classification
of personality disorder. Specifically, use of this specifier may facilitate the identification of
individuals who may respond to certain psychotherapeutic treatments.
A complete description of a particular case of personality disorder includes the rating of the
severity level and the assignment of the applicable trait domain specifiers (e.g. mild personality
disorder with negative affectivity and anankastia; severe personality disorder with dissociality and
disinhibition.) The borderline pattern specifier is considered optional but, if used, should ideally
be used in combination with the trait domain specifiers (e.g. moderate personality disorder with
negative affectivity, dissociality and disinhibition, borderline pattern).
General diagnostic requirements for personality disorder
Essential (required) features
• An enduring disturbance characterized by problems in functioning of aspects of the
self (e.g. identity, self-worth, accuracy of self-view, self-direction) and/or interpersonal
dysfunction (e.g. ability to develop and maintain close and mutually satisfying relationships,
ability to understand others’ perspectives and to manage conflict in relationships) is
required for diagnosis.
• The disturbance has persisted over an extended period of time (e.g. lasting 2 years or more).
• The disturbance is manifested in patterns of cognition, emotional experience, emotional
expression and behaviour that are maladaptive (e.g. inflexible or poorly regulated).
• The disturbance is manifested across a range of personal and social situations (i.e. is not
limited to specific relationships or social roles), although it may be consistently evoked by
particular types of circumstances and not others.
6D11.1
6D11.2
6D11.3
6D11.4
6D11.5
Personality disorders and related traits | General diagnostic requirements for personality disorder
555
Personality disorders and related traits
• The symptoms are not due to the direct effects of a medication or substance, including
withdrawal effects, and are not better accounted for by another mental disorder, a disease
of the nervous system or another medical condition.
• The disturbance is associated with substantial distress or significant impairment in
personal, family, social, educational, occupational or other important areas of functioning.
• Personality disorder should not be diagnosed if the patterns of behaviour characterizing
the personality disturbance are developmentally appropriate (e.g. problems related
to establishing an independent self-identity during adolescence) or can be explained
primarily by social or cultural factors, including sociopolitical conflict.
Severity of personality disorder
The areas of personality functioning shown in Box 6.2 should be considered in making a
severity determination for individuals who meet the general diagnostic requirements for
personality disorder.
Box 6.2. Aspects of personality functioning that contribute to
severity determination in personality disorder
Degree and pervasiveness of disturbances in functioning of aspects of the self
• Stability and coherence of one’s sense of identity (e.g. extent to which identity or sense
of self is variable and inconsistent or overly rigid and fixed)
• Ability to maintain an overall positive and stable sense of self-worth
• Accuracy of one’s view of one’s characteristics, strengths, limitations
• Capacity for self-direction (ability to plan, choose, and implement appropriate goals)
Degree and pervasiveness of interpersonal dysfunction across various contexts
and relationships (e.g. romantic relationships, school/work, parent-child, family,
friendships, peer contexts)
• Interest in engaging in relationships with others
• Ability to understand and appreciate others’ perspectives
• Ability to develop and maintain close and mutually satisfying relationships
• Ability to manage conflict in relationships
Pervasiveness, severity and chronicity of emotional, cognitive and behavioural
manifestations of the personality dysfunction
• Emotional manifestations
• Range and appropriateness of emotional experience and expression
• Tendency to be emotionally over- or underreactive
• Ability to recognize and acknowledge emotions that are difficult or unwanted by the
individual (e.g. anger, sadness)
• Cognitive manifestations
• Accuracy of situational and interpersonal appraisals, especially under stress
• Ability to make appropriate decisions in situations of uncertainty
• Appropriate stability and flexibility of belief systems
• Behavioural manifestations
• Flexibility in controlling impulses and modulating behaviour based on the situation
and consideration of the consequences
• Appropriateness of behavioural responses to intense emotions and stressful
circumstances (e.g. propensity to self-harm or violence)
The extent to which the dysfunctions in the above areas are associated with
distress or impairment in personal, family, social, educational, occupational or
other important areas of functioning
Personality disorders and related traits | General diagnostic requirements for personality disorder

186 - 6D10.0 Mild personality disorder
6D10.0 Mild personality disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Mild personality disorder
Essential (required) features
• All general diagnostic requirements for personality disorder are met.
• Disturbances affect some areas of functioning of the self but not others (e.g. problems with
self-direction in the absence of problems with stability and coherence of identity or selfworth; see Box 6.2), or affect all areas but are of mild severity, and may not be apparent in
some contexts.
• There are problems in many interpersonal relationships or in performance of expected
occupational and social roles, but some relationships are maintained and/or some roles
fulfilled.
• Specific manifestations of personality disturbances are generally of mild severity (see the
examples below).
• Mild personality disorder is typically not associated with substantial harm to self or others.
• Mild personality disorder may be associated with substantial distress or with impairment in
personal, family, social, educational, occupational or other important areas of functioning
that is either limited to circumscribed areas (e.g. romantic relationships; employment) or
present in more areas but of milder severity.
Examples of specific personality disturbances in mild personality disorder
Note: this list of examples is not exhaustive, and it is not intended to suggest that all items will be
present in any single individual.
• The individual’s sense of self may be somewhat contradictory and inconsistent with how
others view them.
• The individual has difficulty recovering from injuries to self-esteem.
• The individual’s ability to set appropriate goals and to work towards them is compromised;
the individual has difficulty handling even minor setbacks.
• The individual may have conflicts with supervisors and co-workers, but is generally able
to sustain employment.
• The individual’s limitations in the ability to understand and appreciate others’ perspectives
create difficulties in development of close and mutually satisfying relationships.
• There may be estrangement in some relationships, but relationships are more commonly
characterized by intermittent or frequent minor conflicts that are not so severe that they
cause serious and longstanding disruption.
• Alternatively, relationships may be characterized by dependence and avoidance of conflict
by giving in to others, even at some cost to themselves.
• Under stress, there may be some distortions in the individual’s situational and interpersonal
appraisals, but reality testing typically remains intact.
6D10.0
Personality disorders and related traits | General diagnostic requirements for personality disorder

187 - 6D10.1 Moderate personality disorder
6D10.1 Moderate personality disorder
557
Personality disorders and related traits
Moderate personality disorder
Essential (required) features
• All general diagnostic requirements for personality disorder are met.
• Disturbances affect multiple areas of functioning of the self (e.g. stability and coherence of
identity, self-worth, self-direction; see Box 6.2) and are of moderate severity.
• There are marked problems in most interpersonal relationships, and the performance of
most expected social and occupational roles is compromised to some degree.
• Relationships are likely to be characterized by conflict, avoidance, withdrawal or extreme
dependency (e.g. few friendships maintained, persistent conflict in work relationships
and consequent occupational problems, romantic relationships characterized by serious
disruption or inappropriate submissiveness).
• Specific manifestations of personality disturbance are generally of moderate severity (see
the examples below).
• Moderate personality disorder is sometimes associated with harm to self or others.
• Moderate personality disorder is associated with marked impairment in personal, family,
social, educational, occupational or other important areas of functioning, although
functioning in circumscribed areas may be maintained.
Examples of specific personality disturbances in moderate personality disorder
Note: this list of examples is not exhaustive, and it is not intended to suggest that all items will be
present in any single individual.
• The individual’s sense of self may become incoherent in times of crisis.
• The individual has considerable difficulty maintaining positive self-esteem. Alternatively,
the individual has an unrealistically positive self-view that is not modified by evidence to
the contrary.
• The individual exhibits poor emotion regulation in the face of setbacks, often becoming
highly upset and giving up easily. Alternatively, the individual may persist unreasonably in
pursuit of goals that have no chance of success.
• The individual may exhibit little genuine interest in or efforts towards sustained
employment.
• Major limitations in the ability to understand and appreciate others’ perspectives hinder
development of close and mutually satisfying relationships.
• There are persistent problems in those relationships that do exist. They may be characterized
by frequent, serious and volatile conflict, or be significantly unbalanced (e.g. the individual
is highly dominant or highly submissive).
• Under stress there are marked distortions in the individual’s situational and interpersonal
appraisals. There may be mild dissociative states or psychotic-like beliefs or perceptions
(e.g. paranoid ideas).
6D10.1
Personality disorders and related traits | General diagnostic requirements for personality disorder

188 - 6D10.2 Severe personality disorder
6D10.2 Severe personality disorder

189 - 6D10.Z Personality disorder, severity unspeci
6D10.Z Personality disorder, severity unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Severe personality disorder
Essential (required) features
• All general diagnostic requirements for personality disorder are met.
• There are severe disturbances in multiple areas of functioning of the self (e.g. sense of self
may be so unstable that individuals report not having a sense of who they are, or so rigid
that they refuse to participate in any but an extremely narrow range of situations; self-view
may be characterized by self-contempt or be grandiose or highly eccentric; see Box 6.2).
• Problems in interpersonal functioning seriously affect virtually all relationships, and
the ability and willingness to perform expected social and occupational roles is severely
compromised or absent.
• Specific manifestations of personality disturbance are severe (see the examples below), and
affect most, if not all, areas of personality functioning.
• Severe personality disorder is often associated with harm to self or others.
• Severe personality disorder is associated with severe impairment in all or nearly all areas
of life, including personal, family, social, educational, occupational and other important
areas of functioning.
Examples of specific personality disturbances in severe personality disorder
Note: this list of examples is not exhaustive, and it is not intended to suggest that all items will be
present in any single individual.
• The individual’s self-view is very unrealistic and is typically highly unstable or contradictory.
• The individual has serious difficulty with regulation of self-esteem, emotional experience
and expression, and impulses, as well as other aspects of behaviour (e.g. perseveration,
indecision).
• The individual is largely unable to set and pursue realistic goals.
• The individual’s interpersonal relationships, if any, lack mutuality; they are shallow,
extremely one-sided, unstable or highly conflictual, often to the point of violence. Family
relationships are absent (despite having living relatives) or marred by significant conflict.
• The individual has extreme difficulty acknowledging difficult or unwanted emotions (e.g.
does not recognize or acknowledge experiencing anger, sadness or other emotions).
• The individual is unwilling or unable to sustain regular work due to lack of interest or
effort, poor performance (e.g. failure to complete assignments or perform expected roles,
unreliability), interpersonal difficulties or inappropriate behaviour (e.g. fits of temper,
insubordination).
• Under stress, there are extreme distortions in the individual’s situational and interpersonal
appraisals. There are often dissociative states or psychotic-like beliefs or perceptions (e.g.
extreme paranoid reactions).
Personality disorder, severity unspecified
6D10.2
6D10.Z
Personality disorders and related traits | General diagnostic requirements for personality disorder

19 - 6A22 Schizotypal disorder
6A22 Schizotypal disorder
177
Schizophrenia and other primary psychotic disorders
Schizotypal disorder
Essential (required) features
• An enduring pattern of unusual speech, perceptions, beliefs and behaviours that are not
of sufficient intensity or duration to meet the diagnostic requirements of schizophrenia,
schizoaffective disorder or delusional disorder is required for diagnosis. The pattern
includes several of the following symptoms:
• constricted affect, such that the individual appears cold and aloof;
• behaviour or appearance that is odd, eccentric, unusual or peculiar, and is inconsistent
with cultural or subcultural norms;
• poor rapport with others and a tendency towards social withdrawal;
• unusual beliefs or magical thinking influencing the person’s behaviour in ways that are
inconsistent with subcultural norms, but not reaching the diagnostic requirements for
a delusion;
• unusual perceptual distortions such as intense illusions, depersonalization, derealization,
or auditory or other hallucinations;
• suspiciousness or paranoid ideas;
• vague, circumstantial, metaphorical, overelaborate or stereotyped thinking, manifested
in odd speech without gross incoherence;
• obsessive ruminations without a sense that the obsession is foreign or unwanted, often
with body dysmorphic, sexual or aggressive content.
• The individual has never met the diagnostic requirements for schizophrenia, schizoaffective
disorder or delusional disorder. That is, transient delusions, hallucinations, formal thought
disorder, or experiences of influence, passivity or control may occur, but do not last for
more than 1 month.
• Symptoms should have been present, continuously or episodically, for at least 2 years.
• The symptoms cause distress or impairment in personal, family, social, educational,
occupational or other important areas of functioning.
• The symptoms are not a manifestation of another medical condition (e.g. a brain tumour),
are not due to the effects of a substance or medication on the central nervous system
(e.g. corticosteroids) – including withdrawal effects (e.g. from alcohol) – and are not better
accounted for by another mental, behavioural or neurodevelopmental disorder.
Additional clinical features
• Schizotypal disorder is more prevalent among biological relatives of people with a diagnosis
of schizophrenia, and is considered to be a part of the spectrum of schizophrenia-related
psychopathology. Having a first-degree relative with schizophrenia gives additional
weight to a diagnosis of schizotypal disorder but is not a requirement if the individual is
experiencing distress or impairment in psychosocial functioning related to their symptoms.
6A22
Schizophrenia and other primary psychotic disorders | Schizotypal disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• The threshold between symptoms of schizotypal disorder and extravagant, eccentric or
unusual behaviour and beliefs in individuals without a diagnosable disorder is sometimes
difficult to determine, especially as some people in the general population show eccentric
behaviour and report psychotic-like or unusual subjective experiences without any
apparent impairment in functioning. Schizotypal disorder should only be diagnosed if the
individual is experiencing distress or impairment in personal, family, social, educational,
occupational or other important areas of functioning related to their symptoms.
Course features
• The course of schizotypal disorder is relatively stable and chronic, with some fluctuation
in symptom intensity. Individuals often have severe functional impairments in academic,
occupational and interpersonal domains.
• The following symptoms of schizotypal disorder are typically present prior to full
symptomatic onset:
• poor rapport with others and a tendency towards social withdrawal, suspiciousness or
paranoid ideas;
• vague, circumstantial, metaphorical, overelaborate or stereotyped thinking, manifested
in odd speech without gross incoherence.
• The disorder may persist over years with fluctuations of intensity and symptom expression,
but rarely evolves into schizophrenia.
• Affected individuals typically seek treatment for co-occurring depressive or anxiety and
fear-related disorders. Although intervention has demonstrated some efficacy in improving
mood and anxiety symptoms, suspicion and paranoia often persist.
Developmental presentations
• Schizotypal disorder typically begins in late adolescence or early adulthood, without a
definite age of onset.
• Some symptoms of schizotypal disorder may first appear in childhood and adolescence,
affecting peer relationships and academic performance.
Schizophrenia and other primary psychotic disorders | Schizotypal disorder
179
Schizophrenia and other primary psychotic disorders
Culture-related features
• A person’s behaviour, appearance, speech or illness explanations may appear odd or
unusual to clinicians who are unfamiliar with the person’s culture, but in the context of
the person’s cultural group may be either normative or not sufficiently severe to reach
the threshold of a mental disorder. Concepts and experiences that are common in some
cultures include witchcraft or sorcery, speaking in tongues, life beyond death, shamanism,
mind reading, sixth sense, evil eye, spirit possession and magical beliefs related to health
and illness.
• Reduced engagement in interpersonal relationships may be part of some cultural or
religious practices (e.g. monastic isolation) and should not be considered pathological.
Sex- and/or gender-related features
• Schizotypal disorder is slightly more prevalent among males.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizophrenia
In the prodromal and residual phases of schizophrenia, the individual may experience extended
periods of perceptual distortions, unusual beliefs, odd or digressive speech, social withdrawal
and other symptoms that are characteristic of schizotypal disorder. A diagnosis of schizophrenia,
however, requires a period of at least 1 month of psychotic symptoms, in contrast to schizotypal
disorder, which requires that any psychotic-like symptoms do not meet the diagnostic requirements
for schizophrenia in terms of severity or duration. Moreover, the pattern of unusual speech,
perceptions, beliefs and behaviours tends to be stable over time – even over years – in individuals
with schizotypal disorder, in contrast to an evolving symptom picture either in prodromal or residual
phases of schizophrenia.
Boundary with autism spectrum disorder
Interpersonal difficulties seen in schizotypal disorder may share some features of autism spectrum
disorder, including poor rapport with others and social withdrawal. However, individuals with
schizotypal disorder do not exhibit restricted, repetitive and stereotyped patterns of behaviour,
interests or activities.
Boundary with personality disorder
Personality disorder is defined as an enduring disturbance in the individual’s way of interpreting
and experiencing themselves, others and the world that result in maladaptive patterns of emotional
expression and behaviour, and produce significant problems in functioning that are particularly
evident in interpersonal relationships. Individuals with schizotypal disorder should not be given an
additional diagnosis of personality disorder based on disturbances in functioning and interpersonal
Schizophrenia and other primary psychotic disorders | Schizotypal disorder

190 - QE50.7 Personality difficulty
QE50.7 Personality difficulty

191 - Specifiers for prominent trait domains in per
Specifiers for prominent trait domains in personality disorder
559
Personality disorders and related traits
Secondary-parented category in personality disorders and
related traits
Personality difficulty
As noted above, personality difficulty is not considered a mental disorder but rather is listed
in the grouping of problems associated with interpersonal interactions in Chapter 24 on
factors influencing health status or contact with health services. Personality difficulty refers to
pronounced personality characteristics that may affect treatment or health services but do not
rise to the level of severity to merit a diagnosis of personality disorder.
Personality difficulty is characterized by longstanding difficulties (e.g. at least 2 years) in the
individual’s way of experiencing and thinking about the self, others and the world. In contrast to
personality disorder, personality difficulty is manifested in cognitive and emotional experience
and expression only intermittently (e.g. during times of stress) or at low intensity. Personality
difficulty is typically associated with some problems in functioning, but these are insufficiently
severe to cause notable disruption in social, occupational and interpersonal relationships, or may
be limited to specific relationships or situations.
Specifiers for prominent trait domains in personality disorder
Trait domain specifiers may be applied to personality disorders or personality difficulty to describe
the characteristics of the individual’s personality that are most prominent and that contribute to
personality disturbance.
Trait domains are continuous with normal personality characteristics in individuals who do not
have personality disorder or personality difficulty. They are not diagnostic categories but rather
represent a set of dimensions that correspond to the underlying structure of personality.
As many trait domain specifiers may be applied as necessary to describe personality functioning.
Individuals with more severe personality disturbance tend to have a greater number of prominent
trait domains. However, a person may have a severe personality disorder and manifest only one
prominent trait domain (e.g. detachment).
Trait domain specifiers that may be recorded include the following.
Negative affectivity
The core feature of the negative affectivity trait domain (sometimes referred to as “neuroticism”)
is the tendency to experience a broad range of negative emotions. Common manifestations of
negative affectivity, not all of which may be present in a given individual at a given time, include
the following.
QE50.7
6D11.0
Personality disorders and related traits | General diagnostic requirements for personality disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Experiencing a broad range of negative emotions with a frequency and intensity out
of proportion to the situation
Common negative emotions include – but are not limited to – anxiety, worry, depression,
vulnerability, fear, anger, hostility, guilt and shame. The particular negative emotions that are most
characteristic of any particular person vary across individuals, and are largely dependent on the
presence or degree of other trait domains. For example, individuals with prominent dissociality
are more likely to experience “externalizing” negative emotions (e.g. anger, hostility, contempt),
whereas those with prominent detachment are more likely to experience “internalizing” negative
emotions (e.g. anxiety, depression, pessimism, guilt).
Emotional lability and poor emotion regulation
Individuals with prominent negative affectivity are overreactive to both their own negative
cognitions and to external events. They can become overwrought through their own thought
processes, such as by ruminating over their shortcomings or past mistakes; over real or perceived
threats, slights or insults; or over potential future problems. They are overreactive to external
threats or criticism, problems and setbacks. They have low frustration tolerance and easily
become visibly upset over even minor issues. They often experience and display multiple emotions
simultaneously, or vacillate among a range of emotions in a short period of time. Once upset, they
have difficulty regaining their composure and must rely on others or on leaving the situation to
calm down.
Negativistic attitudes
Individuals with prominent negative affectivity typically reject others’ suggestions or advice,
arguing that enacting others’ ideas would be too complicated or difficult; or that the suggested
actions would not lead to the desired outcomes, or have a high likelihood of negative consequences.
The manner of rejection is largely dependent on the individual’s other traits. For example, those
with prominent detachment are most likely to blame themselves for the likely difficulties or poor
outcomes, whereas those with prominent dissociality are most likely to blame others for offering
such bad ideas.
Low self-esteem and self-confidence
Individuals with prominent negative affectivity may exhibit low self-esteem and self-confidence
in several different ways. These include avoidance of situations and activities that are judged to
be too difficult (e.g. intellectually, physically, socially, interpersonally, emotionally), even despite
evidence to the contrary; dependency, which may be manifested in frequent reliance on others for
advice, direction and other kinds of help; envy of others’ abilities and indicators of success; and, in
more severe cases of low self-esteem, believing themselves to be useless, to have lived a worthless
life, or to be incapable of accomplishing anything of value, which may be associated with suicidal
ideation or behaviours.
Mistrustfulness
Interpersonally, this is typically manifested in suspicion that others have ill intent, and that
neutral or even benign remarks and positive behaviours are hidden threats, slights or insults.
Individuals with prominent negative affectivity tend to hold grudges and be unforgiving, even
over long time periods. In non-interpersonal situations, this mistrustfulness typically takes the
form of bitterness and cynicism (e.g. the belief that the “system is rigged”).
Personality disorders and related traits | General diagnostic requirements for personality disorder
561
Personality disorders and related traits
Detachment
The core feature of the detachment trait domain is the tendency to maintain interpersonal distance
(social detachment) and emotional distance (emotional detachment). Common manifestations
of detachment, not all of which may be present in a given individual at a given time, include
the following.
Social detachment
Social detachment is characterized by avoidance of social interactions, lack of friendships and
avoidance of intimacy. Individuals with prominent detachment do not enjoy social interactions,
and avoid all kinds of social contact and social situations as far as possible. They engage in little to
no “small talk”, even if initiated by others (e.g. at store check-out counters), seek out employment
that does not involve interactions with others, and even refuse promotions if these would entail
more interaction with others. They have few to no friends or even casual acquaintances. Their
interactions with family members tend to be minimal and superficial. They rarely, if ever, engage
in any intimate relationships, and are not particularly interested in sexual relations.
Emotional detachment
Emotional detachment is characterized by reserve, aloofness and limited emotional expression
and experience. Individuals with prominent detachment keep to themselves as far as possible,
even in obligatory social situations. They are typically aloof, responding to direct attempts at
social engagement only briefly and in ways that discourage further conversation. Emotional
detachment also encompasses emotional inexpressiveness, both verbally and non-verbally.
Individuals with prominent detachment do not talk about their feelings, and it is difficult to
discern what they might be feeling from their behaviours. In extreme cases, there is a lack of
emotional experience itself, and they are non-reactive to either negative or positive events, with a
limited capacity for enjoyment.
Dissociality
The core feature of the dissociality trait domain is disregard for the rights and feelings of others,
encompassing both self-centredness and lack of empathy. Common manifestations of dissociality,
not all of which may be present in a given individual at a given time, include the following.
Self-centredness
Self-centredness in individuals with prominent dissociality is manifested in a sense of entitlement,
believing and acting as if they deserve – without further justification – whatever they want,
preferentially above what others may want or need, and that this “fact” should be obvious to others.
Self-centredness can be manifested both actively/intentionally and passively/unintentionally.
Active – and usually intentional – manifestations of self-centredness include expectation of
others’ admiration, attention-seeking behaviours to ensure being the centre of others’ focus, and
negative behaviours (e.g. anger, “temper tantrums”, denigrating others) when the admiration
and attention that the individual expects are not granted. Typically, such individuals believe that
they have many admirable qualities, that their accomplishments are outstanding, that they have
achieved or will achieve greatness, and that others should admire them. Passive and unintentional
manifestations of self-centredness reflect a kind of obliviousness that other individuals matter as
much as oneself. In this aspect of dissociality, the individual’s concern is with their own needs,
desires and comfort, and those of others simply are not considered.
6D11.2
Personality disorders and related traits | General diagnostic requirements for personality disorder
6D11.1
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Lack of empathy
Lack of empathy is manifested in indifference to whether one’s actions inconvenience others or
hurt them in any way (e.g. emotionally, socially, financially, physically). As a result, individuals
with prominent dissociality are often deceptive and manipulative, exploiting people and situations
to get what they want and think they deserve. This may include being mean and physically
aggressive. In the extreme, this aspect of dissociality can be manifested in callousness with regard
to others’ suffering and ruthlessness in obtaining one’s goals, such that these individuals may
be physically violent with little to no provocation, and may even take pleasure in inflicting pain
and harm. Note that this aspect of dissociality does not necessarily imply that individuals with
prominent dissociality do not cognitively understand the feelings of others; rather, they are not
concerned about them and instead are likely to use this understanding to exploit others.
Disinhibition
The core feature of the disinhibition trait domain is the tendency to act rashly based on immediate
external or internal stimuli (i.e. sensations, emotions, thoughts), without consideration of
potential negative consequences. Common manifestations of disinhibition, not all of which may
be present in a given individual at a given time, include the following.
Impulsivity
Individuals with prominent disinhibition tend to act rashly based on whatever is compelling at
the moment, without consideration of negative consequences for themselves or others, including
putting themselves or others at physical risk. They have difficulty delaying reward or satisfaction,
and tend to pursue immediately available short-term pleasures or potential benefits. In this way,
the trait is strongly associated with such behaviours as substance use, gambling and impulsive
sexual activity.
Distractibility
Individuals with prominent disinhibition also have difficulty staying focused on important and
necessary tasks that require sustained effort. They quickly become bored or frustrated with
difficult, routine or tedious tasks, and are easily distracted by extraneous stimuli, such as others’
conversations. Even in the absence of distractions, they have difficulty keeping their attention
focused and persisting on tasks, and tend to scan the environment for more enjoyable options.
Irresponsibility
Individuals with prominent disinhibition are unreliable and lack a sense of accountability for
their actions. As a result, they often do not complete work assignments or perform expected
duties; they fail to meet deadlines, do not follow through on commitments and promises, and are
late to or miss formal and informal appointments and meetings because they allow themselves to
become engaged in something more compelling that has caught their attention.
Recklessness
Individuals with prominent disinhibition lack an appropriate sense of caution. They tend to
overestimate their abilities and thus frequently do things that are beyond their skill level, without
considering potential safety risks. Individuals with prominent disinhibition may engage in reckless
driving or dangerous sports, or perform other activities that put them or others in physical danger
without sufficient preparation or training.
6D11.3
Personality disorders and related traits | General diagnostic requirements for personality disorder
563
Personality disorders and related traits
Lack of planning
Individuals with prominent disinhibition prefer spontaneous over planned activities, leaving
their options open should a more attractive opportunity arise. They tend to focus on immediate
feelings, sensations and thoughts, with relatively little attention paid to longer-term or even shortterm goals. When they do make plans, they often fail to follow through on them, so they are
seldom able to reach long-term goals, and often fail to achieve even short-term goals.
Anankastia
The core feature of the anankastia trait domain is a narrow focus on one’s rigid standard of perfection
and of right and wrong, on controlling one’s own and others’ behaviour, and on controlling
situations to ensure conformity to these standards. Common manifestations of anankastia, not
all of which may be present in a given individual at a given time, include the following.
Perfectionism
Perfectionism is manifested in concern with social rules, obligations, norms of right and wrong;
scrupulous attention to detail; rigid, systematic, day-to-day routines; excessive scheduling and
planning; and an emphasis on organization, orderliness and neatness. Individuals with prominent
anankastia have a very clear and detailed personal sense of perfection and imperfection that
extends beyond community standards to encompass the individual’s idiosyncratic notions of
what is perfect and right. They believe strongly that everyone should follow all rules exactly and
meet all obligations. Individuals with prominent anankastia may redo the work of others because
it does not meet their perfectionistic standards. They have difficulty in interpersonal relationships
because they hold others to the same standards as themselves, and are inflexible in their views.
Emotional and behavioural constraint
Emotional and behavioural constraint is manifested in rigid control over emotional expression,
stubbornness and inflexibility, risk-avoidance, perseveration and deliberativeness. Individuals
with prominent anankastic traits tightly control their own emotional expression, and disapprove
of others’ displays of emotion. They are inflexible and lack spontaneity, stubbornly insisting on
following set schedules and adhering to plans. Their risk-avoidance includes both refusal to
engage in obviously risky activities and a more general overconcern about avoiding potential
negative consequences of any activity. They often perseverate and have difficulty disengaging
from tasks because they are perceived as not yet perfect down to the last detail. They are highly
deliberative and have difficulty making decisions due to concern that they have not considered
every aspect and all alternatives to ensure that the right decision is made.
Borderline pattern
Note: the borderline pattern specifier has been included to enhance the clinical utility of
the classification of personality disorder. There is considerable overlap between this pattern
and information contained in the trait domain specifiers (most typically negative affectivity,
dissociality and disinhibition). However, use of this specifier may facilitate the identification of
individuals who may respond to certain psychotherapeutic treatments.
6D11.4
6D11.5
Personality disorders and related traits | General diagnostic requirements for personality disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
The borderline pattern specifier may be applied to individuals whose pattern of personality
disturbance is characterized by a pervasive pattern of instability of interpersonal relationships,
self-image and affects, and marked impulsivity, as indicated by five (or more) of the following:
• frantic efforts to avoid real or imagined abandonment;
• a pattern of unstable and intense interpersonal relationships, which may be characterized
by vacillations between idealization and devaluation, typically associated with both strong
desire for and fear of closeness and intimacy;
• identity disturbance, manifested in markedly and persistently unstable self-image or sense
of self;
• a tendency to act rashly in states of high negative affect, leading to potentially self-damaging
behaviours (e.g. risky sexual behaviour, reckless driving, excessive alcohol or substance
use, binge eating);
• recurrent episodes of self-harm (e.g. suicide attempts or gestures, self-mutilation);
• emotional instability due to marked reactivity of mood – fluctuations of mood that may
be triggered either internally (e.g. by one’s own thoughts) or by external events, as a
consequence of which, the individual experiences intense dysphoric mood states, which
typically last for a few hours but may last for up to several days;
• chronic feelings of emptiness;
• inappropriate intense anger or difficulty controlling anger, manifested in frequent displays
of temper (e.g. yelling or screaming, throwing or breaking things, getting into physical
fights);
• transient dissociative symptoms or psychotic-like features (e.g. brief hallucinations,
paranoia) in situations of high affective arousal.
Other manifestations of borderline pattern, not all of which may be present in a given individual
at a given time, include the following:
• a view of the self as inadequate, bad, guilty, disgusting and contemptible;
• an experience of the self as profoundly different and isolated from other people, and a
painful sense of alienation and pervasive loneliness;
• proneness to rejection hypersensitivity, problems in establishing and maintaining
consistent and appropriate levels of trust in interpersonal relationships, and frequent
misinterpretation of social signals.
Additional clinical features of personality disorder
• Personality disorder tends to arise when individuals’ life experiences provide inadequate
support for typical personality development, given the person’s temperament (the aspect
of personality that is considered to be innate, reflecting basic genetic and neurobiological
processes). Thus, early life adversity is a risk factor for later development of personality
disorder, as it is for many other mental disorders. However, it is not determinative: some
individuals’ temperament allows typical personality development despite an extremely
adverse early environment. Nonetheless, in the context of a history of early adversity,
ongoing behavioural, emotional or interpersonal difficulties suggest that a personality
disorder diagnosis should be considered.
Personality disorders and related traits | General diagnostic requirements for personality disorder
565
Personality disorders and related traits
• Personality disorder often complicates and lengthens treatment of other clinical
syndromes. Thus, poor or incomplete response to standard treatments of, for example,
depressive disorders and anxiety and fear-related disorders may suggest the presence of
personality disorder. Relatedly, persistent functional impairment after resolution of the
clinical syndrome(s) being treated may suggest the presence of personality disorder.
• There is often considerable variability in the degree to which individuals and those
around them agree that the individual’s behaviours reflect a particular trait. If there is a
marked discrepancy between an individual’s self-description and the kinds of problematic
behaviours exhibited, it often is helpful to interview someone who knows the person
well. Marked differences between the individual’s self-description and the informant’s
description may be suggestive of personality disorder.
Boundary with normality (threshold) for personality disorder
• Personality refers to an individual’s characteristic way of behaving and experiencing
life, and of perceiving and interpreting themselves, other people, events and situations.
Personality is manifested most directly in how individuals think and feel about themselves
and their interpersonal relationships, how they behave in response to those thoughts and
feelings and in response to others’ behaviours, and how they react to events in their lives and
changes in the environment. An important characteristic of non-disordered personality is
sufficient flexibility to react appropriately and to adapt to other people’s behaviours, life
events and changes in the environment. In personality disorder, patterns of cognition,
emotional experience, emotional expression and behaviour are sufficiently maladaptive
(e.g. inflexible or poorly regulated) that they result in substantial distress or significant
impairment in personal, family, social, educational, occupational or other important areas
of functioning.
• To warrant a diagnosis of personality disorder, personality disturbance must be manifested
across a range of personal and social situations over an extended period of time (e.g.
lasting 2 years or more). Behaviour patterns that are apparent only in the context of
specific relationships, social roles or environmental circumstances, or that have lasted for
a shorter period of time, are not a sufficient basis for a diagnosis of personality disorder.
Instead, the possibility that such behaviour patterns are a response to environmental
circumstances must be considered. A focus on problems in the relevant relationship or in
the environment (e.g. with family or school) may be more appropriate than a diagnosis of
personality disorder in such cases.
Course features
• Manifestations of personality disturbance tend to appear first in childhood, increase
during adolescence, and continue into adulthood, although individuals may not come to
clinical attention until later in life. Caution should be exercised in applying the diagnosis
to children because their personalities are still developing.
Personality disorders and related traits | General diagnostic requirements for personality disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Overt behavioural manifestations of certain traits (dissociality, disinhibition) tend to
decline over the course of adulthood. Other traits (detachment, anankastia) are less likely
to do so. In both cases, functional impairment in broad areas of life (e.g. employment,
interpersonal relationships) among people with personality disorder is often persistent.
• Personality disorder is relatively stable after young adulthood, but may change such that
a person who had personality disorder during young adulthood no longer meets the
diagnostic requirements by middle age.
• Much less commonly, a person who earlier did not have a diagnosable personality disorder
develops one later in life. Emergence of personality disorder in older adults may be related
to the loss of social support that had previously helped to compensate for personality
disturbance.
• When there is a change in personality during middle adulthood or later in life, in the
absence of change in the individual’s environment, the possibility that the change is due to
an underlying medical condition (e.g. secondary personality change) or to an unrecognized
disorder due to substance use should be considered.
Developmental presentations
• Personality disorder is not typically diagnosed in pre-adolescent children. Over the course
of their development, children integrate knowledge and experience about themselves and
other people into a coherent identity and sense of self, as well as into individual styles
of interacting with others. Different children vary substantially in the rate at which this
integration occurs, and there is also substantial variation in the rate of integration within
individuals over time. Therefore, it is very difficult to determine whether a pre-adolescent
child exhibits problems in functioning in aspects of the self, such as identity, self-worth,
accuracy of self-view or self-direction, because these functions are not fully developed
in children. This is also true of interpersonal functions such as the ability to understand
others’ perspectives and to manage conflict in relationships.
• However, prominent maladaptive traits may be observable in pre-adolescent children
and may be precursors to personality disorder in adolescence and adulthood. For
example, individual differences in negative affectivity and disinhibition, as well as more
specific features such as lack of empathy (an aspect of dissociality) and perfectionism (an
aspect of anankastia) may be observed in very young children. However, such traits are
also associated with the development of other mental disorders (e.g. mood disorders,
anxiety and fear-related disorders) and should not be interpreted as childhood forms of
personality disorder.
• Features of personality disorder manifest in similar ways in adolescents and in adults.
However, in evaluating adolescents, it is important to consider the developmental
typicality of the relevant behaviour patterns. For example, risk-taking behaviour, selfharm and moodiness are more common during adolescence than during adulthood.
Therefore, thresholds for evaluating whether such behaviour patterns are indicative of
personality disorder or of elevations in trait domains such as disinhibition and negative
affectivity among adolescents should be correspondingly higher. The wide variability in
normal adolescent development that may affect the expression of these behaviours or
characteristics should also be considered.
Personality disorders and related traits | General diagnostic requirements for personality disorder
567
Personality disorders and related traits
Culture-related features
• Assessment of personality across cultures is challenging, requiring knowledge of normative
personality function for the sociocultural context, variations in cultural concepts of the self,
and evidence for consistent traits and behaviours across time and multiple social contexts.
• Culture shapes modes of self-construal, social presentation and levels of insight about
behaviours that are related to personality development, including what are considered
normal and abnormal personality states in a given setting. For example, children reared in
collectivist societies may develop attachment styles and traits that are viewed as dependent
or avoidant related to the norms of more individualistic cultures. In turn, traits of selfinvolvement that are accepted or positively valued in individualistic cultures may be
considered narcissistic in collectivist cultures.
• Diagnosis of personality disorder must take into account the person’s cultural background.
Collateral information may be needed to assess whether certain disruptive self-states
and behaviours are considered culturally uncharacteristic and therefore consistent with
personality disorder in a given culture. In general, a diagnosis of personality disorder
should be assigned only when the symptoms exceed thresholds that are normative for the
sociocultural context.
• Among ethnic minority, immigrant and refugee communities, responses to discrimination,
social exclusion and acculturative stress may be confused with personality disorder. For
example, suspiciousness or mistrust may be common in situations of endemic racism and
discrimination.
• Sociocultural contexts of exclusion affecting marginal social groups can evoke repeated
attempts at self-affirmation or acceptance by others that are based on ambiguous or
troubled relationships with authority figures and limited adaptability. These reactions may
be confounded with manifestations of borderline pattern, such as impulsivity, instability,
affective lability, explosive/aggressive behaviour or dissociative symptoms. However,
a diagnosis should be assigned only when the symptoms exceed thresholds that are
normative for the sociocultural context.
Sex- and/or gender-related features
• Available evidence indicates that gender distribution of personality disorder is
approximately equal. However, there are significant gender differences in the behavioural
expression of personality disorder and in the associated trait domains. Specifically,
elevations on dissociality and disinhibition are more common among men, and elevations
on negative affectivity are more common among women.
Personality disorders and related traits | General diagnostic requirements for personality disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with personality difficulty
Individuals with pronounced personality characteristics that do not rise to the level of severity to
merit a diagnosis of personality disorder may be considered to have personality difficulty if the
characteristics affect treatment or health services. In contrast to personality disorder, personality
difficulty is manifested only intermittently (e.g. during times of stress) or at low intensity. The
difficulties are associated with some problems in functioning, but these are insufficiently severe
to cause notable disruption in social, occupational and interpersonal relationships, and may be
limited to specific relationships or situations.
Boundary with persistent mental disorders
A number of persistent and enduring mental disorders (e.g. autism spectrum disorder, schizotypal
disorder, dysthymic disorder, cyclothymic disorder, separation anxiety disorder, obsessivecompulsive disorder, complex post-traumatic stress disorder, dissociative identity disorder) are
characterized by enduring disturbances in cognition, emotional experience and behaviour that
are maladaptive, manifested across a range of personal and social situations, and are associated
with significant problems in functioning of aspects of the self (e.g. self-esteem, self-direction) and/
or interpersonal dysfunction (e.g. ability to develop and maintain close and mutually satisfying
relationships, ability to understand others’ perspectives and to manage conflict in relationships).
Accordingly, individuals with these disorders may also meet the diagnostic requirements for
personality disorder. Generally, individuals with such disorders should not be given an additional
diagnosis of personality disorder unless additional personality features are present that contribute
to significant problems in functioning of aspects of the self or interpersonal functioning. However,
even in the absence of these additional features, there may be specific situations in which an
additional diagnosis of personality disorder is warranted (e.g. entry into clinically indicated
forms of treatment that are connected to a personality disorder diagnosis).
Boundary with conduct-dissocial disorder with limited prosocial emotions
Conduct-dissocial disorder is characterized by a recurrent pattern of behaviour in which
the basic rights of others or major age-appropriate social or cultural norms, rules or laws are
violated; this may range in duration from a discrete period lasting a number of months to one
that persists across the lifespan. Conduct-dissocial disorder with limited prosocial emotions is
further characterized by limited or absent empathy or sensitivity to others’ feelings, and limited
or absent remorse, shame or guilt. Conduct-dissocial disorder with limited prosocial emotions
has features in common with personality disorder with dissociality, which is characterized by
disregard for the rights and feelings of other, self-centredness and lack of empathy. Conductdissocial disorder may be diagnosed among pre-adolescent children, based on a shorter duration
of symptoms than personality disorder. Among individuals with conduct-dissocial disorder, an
additional diagnosis of personality disorder is warranted only if there are personality features in
addition to dissociality that contribute to significant impairments in functioning of aspects of the
self or problems in interpersonal functioning.
Boundary with secondary personality change
Secondary personality change is a persistent personality disturbance that represents a change
from the individual’s previous characteristic personality pattern that is judged to be a direct
pathophysiological consequence of a medical condition not classified under mental, behavioural
Personality disorders and related traits | General diagnostic requirements for personality disorder
569
Personality disorders and related traits
Personality disorders and related traits | General diagnostic requirements for personality disorder
and neurodevelopmental disorders, based on evidence from the history, physical examination
or laboratory findings. Personality disorder is not diagnosed if the symptoms are due to another
medical condition.
Boundary with disorders due to substance use
Disorders due to substance use often have pervasive effects on functioning of the self and
interpersonal functioning. For example, they may exhibit problems with self-direction and selfesteem, difficulties and conflicts in relationships, dissocial behaviour related to obtaining or using
drugs, and a wide range of other features that are commonly seen in individuals with personality
disorder. If the personality disturbance is entirely accounted for by a disorder due to substance use,
a diagnosis of personality disorder should not be given. However, if the personality disturbance is
not entirely accounted for by the disorder due to substance use (e.g. if the personality disturbance
preceded the onset of substance use) or if there are features of a personality disorder that are
not accounted for by substance use (e.g. perfectionism), an additional diagnosis of personality
disorder may be assigned.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

192 - Paraphilic disorders
Paraphilic disorders
571
Paraphilic disorders
6D30
Paraphilic disorders
Exhibitionistic disorder
Paraphilic disorders are characterized by persistent and intense patterns of atypical sexual arousal,
manifested in sexual thoughts, fantasies, urges or behaviours, in which the focus of the arousal
pattern involves others whose age or status renders them unwilling or unable to consent (e.g.
pre-pubertal children, an unsuspecting individual being viewed through a window, an animal).
Paraphilic disorders may also involve other atypical sexual arousal patterns if they cause marked
distress to the individual, or may involve significant risk of injury or death.
6D31
Voyeuristic disorder
6D32
Paedophilic disorder
6D33
Coercive sexual sadism disorder
6D34
Frotteuristic disorder
6D35
Other paraphilic disorder involving non-consenting
individuals
6D36
Other paraphilic disorder involving solitary behaviour or
consenting individuals
6D3Z
Paraphilic disorder, unspecified.
In order for the paraphilic disorder to be diagnosed, the individual must have acted on the arousal
pattern, or be markedly distressed by it.
Atypical patterns of sexual arousal that do not involve actions towards others whose age or status
renders them unwilling or unable to consent or that are not associated with marked distress or
significant risk of injury or death are not considered to be paraphilic disorders.
Many sexual crimes involve actions or behaviours that are not associated with a sustained
underlying paraphilic arousal pattern. Rather, these behaviours may be transient and occur
impulsively or opportunistically, or in relation to substance use or intoxication. A diagnosis of
a paraphilic disorder should not be assigned in such cases.
Paraphilic disorders
Paraphilic disorders include the following:

193 - 6D30 Exhibitionistic disorder
6D30 Exhibitionistic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Paraphilic disorders frequently co-occur with a number of other mental disorders, including
mood disorders, anxiety and fear-related disorders, and disorders due to substance use. It
is also common for an individual to meet the diagnostic requirements for more than one
paraphilic disorder.
Paraphilic disorders may be associated with arrest and incarceration, or impairment in functioning
(e.g. at work, in interpersonal relationships), but these are not diagnostic requirements.
Paraphilic disorders should not be diagnosed among children, and should be diagnosed only with
the utmost caution among adolescents. Sexual experimentation is typical during adolescence,
and sexual acts may occur impulsively or opportunistically rather than representing a recurrent
pattern of sexual arousal.
General cultural considerations for paraphilic disorders
• Behavioural norms, thresholds of abnormality, and attitudes and interpretations regarding
paraphilic disorders vary across cultures. Accurate assessment requires information about
the etiology, function and consequences of the symptoms across cultural groups.
Exhibitionistic disorder
Essential (required) features
• A sustained, focused and intense pattern of sexual arousal – as manifested in persistent
sexual thoughts, fantasies, urges or behaviours – that involves exposing one’s genitals to an
unsuspecting person in public places, usually without inviting or intending closer contact,
is required for diagnosis.
• The individual must have acted on these thoughts, fantasies or urges, or be markedly
distressed by them.
Additional clinical features
• Exhibitionistic disorder should not be diagnosed among children, and should be diagnosed
only with the utmost caution among adolescents. Sexual experimentation is typical during
adolescence, and exhibitionistic acts may occur impulsively or opportunistically rather
than representing a recurrent pattern of sexual arousal.
• The diagnosis of exhibitionistic disorder is generally not adequately supported when the
evidence indicating a sustained, focused and intense pattern of sexual arousal consists
solely of a single or very limited number of instances of exhibitionistic behaviour, as there
may be other explanations for specific occurrences (e.g. intoxication, opportunity). In the
absence of the individual’s report of their sexual thoughts, fantasies or urges indicating
6D30
Paraphilic disorders | Exhibitionistic disorder
573
Paraphilic disorders
a sustained, focused and intense pattern of exhibitionistic sexual arousal, examples
of other forms of evidence that may support the presence of an exhibitionistic arousal
pattern include a preference for specific types of pornography; preference over other forms
of sexual behaviour; or planning and repeatedly seeking out opportunities to engage in
exhibitionistic behaviour.
Boundary with normality (threshold)
• By definition, exhibitionistic disorder specifically excludes consensual exhibitionistic
behaviours that occur with the consent of the individuals involved. Moreover, in some
cultures there are socially sanctioned forms of public nudity, which do not constitute
exhibitionistic disorder.
Course features
• Individuals with exhibitionistic disorder often report the onset of exhibitionistic sexual
interest during adolescence.
• Exhibitionistic disorder is relatively stable after young adulthood, but sexual thoughts,
fantasies, urges and behaviours may change over time, such that an individual who
was previously assigned a diagnosis of exhibitionistic disorder no longer meets the
diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
behavioural manifestations of exhibitionistic disorder due to increased impulse control
and decreased sexual drive.
Culture-related features
• Laws defining what is considered exhibitionistic behaviour may vary across cultures,
including by gender. In addition, cultures vary regarding acceptance of the practice of
nudity and its appropriateness in specific contexts (e.g. pornography, saunas, nudist
settings). In these contexts, certain behaviours may not be considered exhibitionistic by
the cultural group.
Paraphilic disorders | Exhibitionistic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Exhibitionistic disorder is much more common among men.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both exhibitionistic disorder and compulsive sexual behaviour disorder may involve repetitive
sexual impulses, urges or behaviours that result in marked distress or impairment. Exhibitionistic
disorder is characterized by sexual impulses, urges or behaviours that are manifestations of a
sustained, focused and intense pattern of sexual arousal that involves exposing one’s genitals to
an unsuspecting person in public places. In contrast, compulsive sexual behaviour disorder is
characterized by a persistent pattern of failure to control sexual impulses, urges or behaviours,
regardless of the focus of sexual arousal. If an individual with exhibitionistic disorder is able
to exercise some degree of control over the behavioural expressions of the arousal pattern, an
additional diagnosis of compulsive sexual behavioural disorder is generally not warranted.
Boundary with disorders due to substance use
Episodes of impulsive or disinhibited sexual behaviour, including exhibitionistic behaviour, may
occur during substance intoxication. Such episodes may not be a manifestation of a sustained,
focused and intense sexual arousal pattern. At the same time, some individuals with exhibitionistic
disorder may use substances with the intention of engaging in exhibitionistic behaviour that does
reflect an underlying paraphilic arousal pattern. A diagnosis of exhibitionistic disorder may be
assigned together with a disorder due to substance use if the diagnostic requirements for both
are met.
Boundary with other mental disorders
The occurrence or a history of behaviours involving exposing oneself to non-consenting individuals
is not sufficient to establish a diagnosis of exhibitionistic disorder. Rather, these behaviours must
reflect a sustained, focused and intense pattern of sexual arousal. When this is not the case, other
causes of the behaviour need to be considered. For example, exhibitionistic behaviours that do
not reflect an underlying, persistent pattern of sexual arousal may occur in the context of some
mental disorders, such as bipolar type I disorder during manic or mixed episodes, or dementia.
Boundary with sexual crimes that do not involve a paraphilic disorder
Sexual crimes involving exhibitionistic behaviour may consist of actions or behaviours that are
not associated with a sustained underlying paraphilic arousal pattern. Rather, these behaviours
may be transient and occur impulsively or opportunistically. The diagnosis of exhibitionistic
disorder requires these behaviours to be a manifestation of a sustained, focused and intense
pattern of sexual arousal.
Paraphilic disorders | Exhibitionistic disorder

194 - 6D31 Voyeuristic disorder
6D31 Voyeuristic disorder
575
Paraphilic disorders
Voyeuristic disorder
Essential (required) features
• A sustained, focused and intense pattern of sexual arousal – as manifested in persistent
sexual thoughts, fantasies, urges or behaviours – that involves observing an unsuspecting
person who is naked, in the process of disrobing, or engaging in sexual activity, is required
for diagnosis.
• The individual must have acted on these thoughts, fantasies or urges, or be markedly
distressed by them.
Additional clinical features
• Voyeuristic disorder should not be diagnosed among children, and is not typically
diagnosed among adolescents. Sexual curiosity is typical during adolescence, and
observation of others may occur impulsively or opportunistically rather than representing
a recurrent pattern of sexual arousal.
• The act of observing in voyeuristic disorder is for the purpose of achieving sexual
excitement, and does not necessarily involve an attempt to initiate sexual activity with the
person being observed. Orgasm by masturbation may occur during the voyeuristic activity
or later in response to memories of what the individual has seen. More recently, so-called
“video voyeurs” have been described who use video equipment to record individuals in
public or private places where there is an expectation of privacy.
• The diagnosis of voyeuristic disorder is generally not adequately supported when the
evidence indicating a sustained, focused and intense pattern of sexual arousal consists solely
of a single or very limited number of instances of voyeuristic behaviour, as there may be
other explanations for specific occurrences (e.g. intoxication, opportunity). In the absence
of a report of the individual’s sexual thoughts, fantasies or urges, examples of other forms
of evidence supporting the presence of a voyeuristic arousal pattern include a preference
for specific types of pornography; preference over other forms of sexual behaviour; or
planning and repeatedly seeking out opportunities to engage in voyeuristic behaviour.
Boundary with normality (threshold)
• By definition, voyeuristic disorder specifically excludes consensual voyeuristic behaviours
that occur with the consent of the individual being observed.
6D31
Paraphilic disorders | Voyeuristic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Course features
• Individuals with voyeuristic disorder often report the onset of voyeuristic sexual interest
during adolescence.
• Voyeuristic disorder is relatively stable after young adulthood, but sexual thoughts,
fantasies, urges and behaviours may change over time, such that an individual who was
assigned a diagnosis of voyeuristic disorder no longer meets the diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
behavioural manifestations of voyeuristic disorder due to increased impulse control and
decreased sexual drive.
Sex- and/or gender-related features
• Voyeuristic disorder is much more prevalent among men.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both voyeuristic disorder and compulsive sexual behaviour disorder may involve repetitive
sexual impulses, urges or behaviours that result in marked distress or impairment. Voyeuristic
disorder is characterized by sexual impulses, urges or behaviours that are manifestations of a
sustained, focused and intense pattern of sexual arousal that involves stimuli such as observing an
unsuspecting person who is naked, in the process of disrobing, or engaging in sexual activity. In
contrast, compulsive sexual behaviour disorder is characterized by a persistent pattern of failure
to control sexual impulses, urges or behaviours, regardless of the focus of sexual arousal. If an
individual with voyeuristic disorder is able to exercise some degree of control over the behavioural
expressions of the arousal pattern, an additional diagnosis of compulsive sexual behavioural
disorder is generally not warranted.
Boundary with disorders due to substance use
Episodes of impulsive or disinhibited sexual behaviour, including voyeuristic behaviour, may
occur during substance intoxication. Such episodes may not be a manifestation of a sustained,
Paraphilic disorders | Voyeuristic disorder

195 - 6D32 Paedophilic disorder
6D32 Paedophilic disorder
577
Paraphilic disorders
focused and intense sexual arousal pattern. At the same time, some individuals with voyeuristic
disorder may use substances with the intention of engaging in voyeuristic behaviour that does
reflect an underlying paraphilic arousal pattern. A diagnosis of voyeuristic disorder may be
assigned together with a disorder due to substance use if the diagnostic requirements for both
are met.
Boundary with other mental disorders
The occurrence or a history of behaviours involving observing an unsuspecting individual who
is naked, in the process of disrobing, or engaging in sexual activity is insufficient to establish a
diagnosis of voyeuristic disorder. Rather, these behaviours must reflect a sustained, focused and
intense pattern of sexual arousal. When this is not the case, other causes of the behaviour need to
be considered. For example, voyeuristic behaviours that do not reflect an underlying, persistent
pattern of sexual arousal may occur in the context of some mental disorders, such as bipolar type
I disorder during manic or mixed episodes, or dementia.
Boundary with sexual crimes that do not involve a paraphilic disorder
Sexual crimes involving voyeuristic behaviour may consist of actions or behaviours that are not
associated with a sustained underlying paraphilic arousal pattern. Rather, these behaviours may
be transient and occur impulsively or opportunistically. The diagnosis of voyeuristic disorder
requires these behaviours to be a manifestation of a sustained, focused and intense pattern of
sexual arousal.
Paedophilic disorder
Essential (required) features
• A sustained, focused and intense pattern of sexual arousal – as manifested in persistent
sexual thoughts, fantasies, urges or behaviours – involving pre-pubertal children is
required for diagnosis.
• The individual must have acted on these thoughts, fantasies or urges, or be markedly
distressed by them.
• The diagnosis does not apply to sexual arousal and accompanying behaviour between preor post-pubertal children who are close in age.
Additional clinical features
• Paedophilic disorder should not be diagnosed among children, and should be diagnosed
only with the utmost caution among adolescents. Sexual experimentation is typical during
adolescence, and sexual acts may occur impulsively or opportunistically rather than
representing a recurrent pattern of sexual arousal.
6D32
Paraphilic disorders | Paedophilic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The diagnosis of paedophilic disorder is generally not adequately supported when the
evidence indicating a sustained, focused and intense pattern of sexual arousal consists
solely of a single or very limited number of instances of paedophilic behaviour, as there
may be other explanations for specific occurrences (e.g. intoxication, opportunity). In the
absence of a report of the individual’s sexual thoughts, fantasies or urges, examples of
other forms of evidence supporting the presence of a paedophilic arousal pattern include
a preference for specific types of pornography; preference over other forms of sexual
behaviour; planning and repeatedly seeking out opportunities to engage in paedophilic
behaviour; or laboratory measures of relative viewing time (based on the finding that
preferred sexual stimuli are gazed at longer than non-preferred sexual stimuli) and/or
penile plethysmography.
• Some individuals with paedophilic disorder are attracted only to males, others only to
females, and others to both.
• Some individuals act on their paedophilic urges only with family members, others only
with people outside their immediate family, and others with both.
Boundary with normality (threshold)
• A broad range of sexual behaviour with peers may occur in children or adolescents.
A diagnosis of paedophilic disorder should not be assigned on the basis of sexual behaviours
among pre- or post-pubertal children or adolescents with peers who are close in age.
Course features
• Individuals with paedophilic disorder often report the onset of paedophilic sexual interest
during adolescence.
• Paedophilic disorder is relatively stable after young adulthood, but sexual thoughts,
fantasies, urges and behaviours may change over time, such that an individual who was
assigned a diagnosis of paedophilic disorder no longer meets the diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
behavioural manifestations of paedophilic disorder due to increased impulse control and
decreased sexual drive.
Paraphilic disorders | Paedophilic disorder
579
Paraphilic disorders
Culture-related features
• Cultures vary in their legal definition of what constitutes a child or adolescent. The Tanner
stages – a scale of physical development, including primary and secondary sexual
characteristics across the lifespan – may provide a more objective basis than age on which
to base a definition.
• Cultures vary regarding the forms of affection that are considered appropriate between
children and adults. For example, it is normative in some cultures for parents to kiss their
children on the mouth as a sign of affection. Culturally normative behaviour should not be
misattributed as inappropriate sexual activity.
Sex- and/or gender-related features
• Paedophilic disorder is much more prevalent among men.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both paedophilic disorder and compulsive sexual behaviour disorder may involve repetitive
sexual impulses, urges or behaviours that result in marked distress or impairment. Paedophilic
disorder is characterized by sexual impulses, urges or behaviours that are manifestations of a
sustained, focused and intense pattern of sexual arousal involving pre-pubertal children.
In contrast, compulsive sexual behaviour disorder is characterized by a persistent pattern of
failure to control sexual impulses, urges or behaviours, regardless of the focus of sexual arousal.
If an individual with paedophilic disorder is able to exercise some degree of control over the
behavioural expressions of the arousal pattern, an additional diagnosis of compulsive sexual
behavioural disorder is generally not warranted.
Boundary with obsessive-compulsive disorder
Some individuals with obsessive-compulsive disorder experience intrusive thoughts and images
about possible attraction or sexual abuse of children. These are typically highly distressing to the
individual, and are not accompanied by sexual arousal; they therefore do not reflect an underlying
paraphilic arousal pattern, even though the individual may be concerned that they do. These
individuals may also experience other ego-dystonic thoughts or images with sexual content that
are not experienced as sexually arousing.
Boundary with disorders due to substance use
Episodes of impulsive or disinhibited sexual behaviour, including paedophilic behaviour, may
occur during substance intoxication. Such episodes may not be a manifestation of a sustained,
Paraphilic disorders | Paedophilic disorder

196 - 6D33 Coercive sexual sadism disorder
6D33 Coercive sexual sadism disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
focused and intense sexual arousal pattern. At the same time, some individuals with paedophilic
disorder may use substances with the intention of engaging in paedophilic behaviour that does
reflect an underlying paraphilic arousal pattern. A diagnosis of paedophilic disorder may be
assigned together with a disorder due to substance use if the diagnostic requirements for both
are met.
Boundary with other mental disorders
The occurrence or a history of sexual behaviours involving pre-pubertal children is not sufficient
to establish a diagnosis of paedophilic disorder. Rather, these behaviours must reflect a sustained,
focused and intense pattern of paedophilic sexual arousal. When this is not the case, other causes
of the behaviour need to be considered. For example, sexual behaviours involving children that
do not reflect an underlying, persistent pattern of paedophilic sexual arousal may occur in the
context of some mental disorders, such as bipolar type I disorder during manic or mixed episodes,
or dementia.
Boundary with sexual crimes that do not involve a paraphilic disorder
Sexual crimes involving paedophilic behaviour may consist of actions or behaviours that are not
associated with a sustained underlying paraphilic arousal pattern. Rather, these behaviours may
be transient and occur impulsively or opportunistically. The diagnosis of paedophilic disorder
requires these behaviours to be a manifestation of a sustained, focused and intense pattern of
sexual arousal.
Boundary with sexually aggressive behaviour in adolescents
Some adolescents present with a history of sexually abusing younger children. The diagnosis of
paedophilic disorder should be applied with caution to adolescents. Unless there is a persistent
pattern of such behaviour, reflecting a sustained, focused and intense pattern of sexual arousal
focused on pre-pubertal children, the diagnosis of paedophilic disorder is not appropriate.
Coercive sexual sadism disorder
Essential (required) features
• A sustained, focused and intense pattern of sexual arousal – as manifested in persistent
sexual thoughts, fantasies, urges or behaviours – that involves the infliction of physical or
psychological suffering on a non-consenting person is required for diagnosis.
• The individual must have acted on these thoughts, fantasies or urges, or be markedly
distressed by them.
6D33
Paraphilic disorders | Coercive sexual sadism disorder
581
Paraphilic disorders
Additional clinical features
• Coercive sexual sadism disorder should not be diagnosed among children, and should
be diagnosed only with the utmost caution among adolescents. Sexual acts may occur
impulsively or opportunistically during adolescence rather than representing a recurrent
pattern of sexual arousal.
• The diagnosis of coercive sexual sadism disorder is generally not adequately supported
when the evidence indicating a sustained, focused and intense pattern of sexual arousal
consists solely of a single or very limited number of instances of coercive sadistic sexual
behaviour, as there may be other explanations for specific occurrences (e.g. intoxication,
opportunity). In the absence of a report of the individual’s sexual thoughts, fantasies or
urges, examples of other forms of evidence supporting the presence of a coercive sadistic
arousal pattern include a preference for specific types of pornography; preference over
other forms of sexual behaviour; planning and repeatedly seeking out opportunities to
engage in coercive sadistic sexual behaviour; or laboratory measures of relative viewing
time (based on the finding that preferred sexual stimuli are gazed at longer than nonpreferred sexual stimuli) and/or penile plethysmography.
Boundary with normality (threshold)
• By definition, coercive sexual sadism disorder specifically excludes consensual sexual
sadism and consensual masochism.
Course features
• Individuals with coercive sexual sadism disorder often report the onset of coercive sadistic
sexual interest during adolescence.
• Coercive sexual sadism disorder is relatively stable after young adulthood, but sexual
thoughts, fantasies, urges and behaviours may change over time, such that an individual
who was assigned a diagnosis of coercive sexual sadism disorder no longer meets the
diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
behavioural manifestations of coercive sexual sadism disorder due to increased impulse
control and decreased sexual drive.
Paraphilic disorders | Coercive sexual sadism disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Coercive sexual sadism disorder is much more prevalent among men.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both coercive sexual sadism disorder and compulsive sexual behaviour disorder may involve
repetitive sexual impulses, urges or behaviours that result in marked distress or impairment.
Coercive sexual sadism disorder is characterized by sexual impulses, urges or behaviours that
are manifestations of a sustained, focused and intense pattern of sexual arousal that involves
the infliction of physical or psychological suffering on a non-consenting person. In contrast,
compulsive sexual behaviour disorder is characterized by a persistent pattern of failure to control
sexual impulses, urges or behaviours, regardless of the focus of sexual arousal. If an individual with
coercive sexual sadism disorder is able to exercise some degree of control over the behavioural
expressions of the arousal pattern, an additional diagnosis of compulsive sexual behavioural
disorder is generally not warranted.
Boundary with conduct-dissocial disorder
Conduct-dissocial disorder is characterized by a pervasive pattern of disregard for and violation
of the rights of others. Coercive or sadistic sexual behaviours that occur in the context of conductdissocial disorder but that do not reflect an underlying, persistent pattern of sexual arousal
involving the infliction of physical or psychological suffering should not be used as a basis for
diagnosing coercive sexual sadism disorder.
Boundary with disorders due to substance use
Episodes of impulsive or disinhibited sexual behaviour, including coercive sexual behaviour, may
occur during substance intoxication. Such episodes may not be a manifestation of a sustained,
focused and intense sexual arousal pattern. At the same time, some individuals with coercive
sexual sadism disorder may use substances with the intention of engaging in coercive sexual
behaviour that does reflect an underlying paraphilic arousal pattern. A diagnosis of coercive
sexual sadism disorder may be assigned together with a disorder due to substance use if the
diagnostic requirements for both are met.
Boundary with other mental disorders
The occurrence or a history of sexual behaviours involving the infliction of physical or
psychological suffering on non-consenting individuals is not sufficient to establish a diagnosis
of coercive sexual sadism disorder. Rather, these behaviours must reflect a sustained, focused
and intense pattern of coercive sexual sadistic arousal. When this is not the case, other causes
of the behaviour need to be considered. For example, coercive sexual behaviour may occur in
the context of some mental disorders, such as a bipolar type I disorder during manic or mixed
episodes, or dementia.
Paraphilic disorders | Coercive sexual sadism disorder

197 - 6D34 Frotteuristic disorder
6D34 Frotteuristic disorder
583
Paraphilic disorders
Boundary with sexual crimes that do not involve a paraphilic disorder
Sexual crimes involving coercive sexual behaviours may consist of actions or behaviours that are
not associated with a sustained underlying paraphilic arousal pattern. Rather, these behaviours
may be transient and occur impulsively or opportunistically. The diagnosis of coercive sexual
sadism disorder requires these behaviours to be a manifestation of a sustained, focused and
intense pattern of sexual arousal.
Frotteuristic disorder
Essential (required) features
• A sustained, focused and intense pattern of sexual arousal – as manifested in persistent
sexual thoughts, fantasies, urges or behaviours – that involves touching or rubbing against
a non-consenting person is required for diagnosis.
• The individual must have acted on these thoughts, fantasies or urges, or be markedly
distressed by them.
Additional clinical features
• Frotteuristic disorder should not be diagnosed among children, and should be diagnosed
only with the utmost caution among adolescents. Sexual experimentation is typical during
adolescence, and sexual acts may occur impulsively or opportunistically rather than
representing a recurrent pattern of sexual arousal.
• The diagnosis of frotteuristic disorder is generally not adequately supported when the
evidence indicating a sustained, focused and intense pattern of sexual arousal consists
solely of a single or very limited number of instances of frotteuristic behaviour, as there
may be other explanations for specific occurrences (e.g. intoxication, opportunity). In the
absence of a report of the individual’s sexual thoughts, fantasies or urges, examples of other
forms of evidence supporting the presence of an frotteuristic arousal pattern include a
preference for specific types of pornography; preference over other forms of sexual beh
aviour; or planning and repeatedly seeking out opportunities to engage in
frotteuristic behaviour.
Boundary with normality (threshold)
• By definition, frotteuristic disorder specifically excludes consensual touching or rubbing
that occurs with the consent of the individual involved.
6D34
Paraphilic disorders | Frotteuristic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Course features
• Individuals with frotteuristic disorder often report the onset of frotteuristic sexual interest
during adolescence.
• Frotteuristic disorder is relatively stable after young adulthood, but sexual thoughts,
fantasies, urges and behaviours may change over time, such that an individual who was
assigned a diagnosis of frotteuristic disorder no longer meets the diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
behavioural manifestations of frotteuristic disorder due to increased impulse control and
decreased sexual drive.
Sex- and/or gender-related features
• Frotteuristic disorder is much more prevalent among men.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both frotteuristic disorder and compulsive sexual behaviour disorder may involve repetitive
sexual impulses, urges or behaviours that result in marked distress or impairment. Frotteuristic
disorder is characterized by sexual impulses, urges or behaviours that are manifestations of a
sustained, focused and intense pattern of sexual arousal that involves touching or rubbing against
a non-consenting person. In contrast, compulsive sexual behaviour disorder is characterized by
a persistent pattern of failure to control sexual impulses, urges or behaviours, regardless of the
focus of sexual arousal. If an individual with frotteuristic disorder is able to exercise some degree
of control over the behavioural expressions of the arousal pattern, an additional diagnosis of
compulsive sexual behavioural disorder is generally not warranted.
Boundary with disorders due to substance use
Episodes of impulsive or disinhibited sexual behaviour, including frotteuristic behaviour, may
occur during substance intoxication. Such episodes may not be a manifestation of a sustained,
focused and intense sexual arousal pattern. At the same time, some individuals with frotteuristic
Paraphilic disorders | Frotteuristic disorder

198 - 6D35 Other paraphilic disorder involving non
6D35 Other paraphilic disorder involving non-consenting individuals
585
Paraphilic disorders
disorder may use substances with the intention of engaging in frotteuristic behaviour that does
reflect an underlying paraphilic arousal pattern. A diagnosis of frotteuristic disorder may be
assigned together with a disorder due to substance use if the diagnostic requirements for both
are met.
Boundary with other mental disorders
The occurrence or a history of behaviours involving sexual touching or rubbing against nonconsenting individuals is not sufficient to establish a diagnosis of frotteuristic disorder. Rather,
these behaviours must reflect a sustained, focused and intense pattern of sexual arousal. When this
is not the case, other causes of the behaviour need to be considered. For example, inappropriate
touching or rubbing against others that does not reflect an underlying, persistent pattern of sexual
arousal may occur in the context of some mental disorders, such as bipolar type I disorder during
manic or mixed episodes, or dementia.
Boundary with sexual crimes that do not involve a paraphilic disorder
Sexual crimes involving frotteuristic behaviour may consist of actions or behaviours that are not
associated with a sustained underlying paraphilic arousal pattern. Rather, these behaviours may
be transient and occur impulsively or opportunistically. The diagnosis of frotteuristic disorder
requires sexual touching or rubbing behaviours to be a manifestation of a sustained, focused and
intense pattern of sexual arousal.
Other paraphilic disorder involving non-consenting individuals
Essential (required) features
• A sustained, focused and intense pattern of atypical sexual arousal – as manifested in
sexual thoughts, fantasies, urges or behaviours – in which the focus of the arousal pattern
involves others who are unwilling or unable to consent is required for diagnosis.
• The arousal pattern is not specifically described by any of the other named paraphilic
disorders categories (e.g. arousal patterns involving corpses or animals).
• The presentation does not fulfil the diagnostic requirements of coercive sexual sadism
disorder, paedophilic disorder, voyeuristic disorder, exhibitionistic disorder or frotteuristic
disorder.
• The individual must have acted on these thoughts, fantasies or urges, or be markedly
distressed by them.
Additional clinical features
• Other paraphilic disorder involving non-consenting individuals should not be diagnosed
among children, and should be diagnosed only with the utmost caution among
adolescents. Sexual experimentation is typical during adolescence, and sexual acts may
occur impulsively or opportunistically rather than representing a recurrent pattern of
sexual arousal.
6D35
Paraphilic disorders | Other paraphilic disorder involving non-consenting individuals
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• A diagnosis of other paraphilic disorder involving non-consenting individuals is generally
not adequately supported when the evidence indicating a sustained, focused and intense
pattern of sexual arousal consists solely of a single or very limited number of instances
of specific forms of sexual behaviour, as there may be other explanations for specific
occurrences (e.g. intoxication, opportunity). In the absence of a report of the individual’s
sexual thoughts, fantasies or urges, examples of other forms of evidence supporting
the presence of a paraphilic arousal pattern include a preference for specific types of
pornography; preference over other forms of sexual behaviour; or planning and repeatedly
seeking out opportunities to engage in the relevant paraphilic sexual behaviour.
Boundary with normality (threshold)
• Other paraphilic disorder involving non-consenting individuals specifically excludes
sexual behaviours that occur with the consent of the person or people involved, as long as
they are deemed to have the capacity to provide such consent.
Course features
• Individuals with paraphilic disorders often report the onset of paraphilic sexual interest
during adolescence.
• Paraphilic disorders are relatively stable after young adulthood, but sexual thoughts,
fantasies, urges and behaviours may change over time, such that an individual who was
assigned a diagnosis of a paraphilic disorder no longer meets the diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
behavioural manifestations of paraphilic disorders due to increased impulse control and
decreased sexual drive.
Sex- and/or gender-related features
• Paraphilic disorders are much more prevalent among men.
Paraphilic disorders | Other paraphilic disorder involving non-consenting individuals
587
Paraphilic disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both other paraphilic disorder involving non-consenting individuals and compulsive sexual
behaviour disorder may involve repetitive sexual impulses, urges or behaviours that result in
marked distress or impairment. Other paraphilic disorder involving non-consenting individuals
is characterized by sexual impulses, urges or behaviours that are manifestations of a sustained,
focused and intense pattern of sexual arousal, in which the focus of the arousal pattern involves
others who are unwilling or unable to consent, that is not specifically described in any of the
other named paraphilic disorders categories. In contrast, compulsive sexual behaviour disorder
is characterized by a persistent pattern of failure to control sexual impulses, urges or behaviours,
regardless of the focus of sexual arousal. If an individual with other paraphilic disorder involving
non-consenting individuals is able to exercise some degree of control over the behavioural
expressions of the arousal pattern, an additional diagnosis of compulsive sexual behavioural
disorder is generally not warranted.
Boundary with disorders due to substance use
Episodes of sexual behaviour involving others whose age or status renders them unwilling
or unable to consent may occur during substance intoxication. Such episodes may not be a
manifestation of a sustained, focused and intense sexual arousal pattern. At the same time, some
individuals with paraphilic disorders may use substances with the intention of engaging in sexual
behaviour involving others whose age or status renders them unwilling or unable to consent that
does reflect an underlying paraphilic arousal pattern. A diagnosis of other paraphilic disorder
involving non-consenting individuals may be assigned together with a disorder due to substance
use if the diagnostic requirements for both are met.
Boundary with other mental disorders
The occurrence or a history of sexual behaviours involving others whose age or status renders
them unwilling or unable to consent is not sufficient to establish a diagnosis of other paraphilic
disorder involving non-consenting individuals. Rather, these sexual behaviours must reflect a
sustained, focused and intense pattern of sexual arousal. When this is not the case, other causes
of the sexual behaviour need to be considered. For example, sexual behaviours involving nonconsenting individuals that do not reflect an underlying, persistent pattern of sexual arousal may
occur in the context of some mental disorders, such as bipolar type I disorder during manic or
mixed episodes, or dementia.
Boundary with sexual crimes that do not involve a paraphilic disorder
Sexual crimes involving non-consenting individuals may consist of actions or behaviours that are
not associated with a sustained underlying paraphilic arousal pattern. Rather, these behaviours
may be transient and occur impulsively or opportunistically. The diagnosis of other paraphilic
disorder involving non-consenting individuals requires these behaviours to be a manifestation of
a sustained, focused and intense pattern of paraphilic sexual arousal.
Paraphilic disorders | Other paraphilic disorder involving non-consenting individuals

199 - 6D36 Paraphilic disorder involving solitary b
6D36 Paraphilic disorder involving solitary behaviour or consenting individuals
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Paraphilic disorder involving solitary behaviour or consenting
individuals
Essential (required) features
• A sustained, focused and intense pattern of atypical sexual arousal – as manifested in
sexual thoughts, fantasies, urges or behaviours – that involves consenting adults or solitary
behaviour is required for diagnosis.
• One of the following two elements must be present.
• The individual is markedly distressed by the nature of the arousal pattern and the distress
is not simply a consequence of rejection or feared rejection of the arousal pattern by
others.
• The nature of the paraphilic behaviour involves significant risk of injury or death either to
the individual (e.g. asphyxophilia or achieving sexual arousal by restriction of breathing)
or to the individual’s partner (e.g. consensual sadism that results in injuries requiring
medical attention).
• If the diagnosis is assigned based on significant risk of injury or death, this risk should be
directly and immediately connected to the paraphilic behaviour. For example, a presumed
risk of increased exposure to sexually transmitted infections is not a sufficient basis for
assigning this diagnosis.
Additional clinical features
• Paraphilic disorder involving solitary behaviour or consenting individuals should not be
diagnosed among children, and should be diagnosed only with the utmost caution among
adolescents. Sexual experimentation is typical during adolescence, and sexual acts may
occur impulsively or opportunistically rather than representing a recurrent pattern of
sexual arousal.
• Diagnosis of paraphilic disorder involving solitary behaviour or consenting individuals
generally requires a report of sexual thoughts, fantasies, urges and behaviours directly from
the individual in order to document a sustained, focused and intense pattern of atypical
sexual arousal, and the degree and sources of related distress.
Boundary with normality (threshold)
• The fact that an individual’s pattern of sexual arousal deviates from social or cultural norms
is not a basis for assigning a diagnosis of paraphilic disorder involving solitary behaviour
or consenting individuals. An arousal pattern that involves consenting adults or solitary
behaviour, and that is not associated with marked distress that is not simply a consequence
6D36
Paraphilic disorders | Paraphilic disorder involving solitary behaviour or consenting individuals
589
Paraphilic disorders
of rejection or feared rejection of the arousal pattern by others or with a significant risk of
injury or death, is not considered a disorder.
• The occurrence or a history of atypical sexual behaviours is not sufficient to establish a
diagnosis of paraphilic disorder involving solitary behaviour or consenting individuals.
Some atypical sexual behaviours may occur impulsively or opportunistically, or as a means
of personal and sexual exploration, and are not associated with a sustained underlying
arousal pattern. The diagnosis of paraphilic disorder involving solitary behaviour or
consenting individuals requires these behaviours to be a manifestation of a sustained,
focused and intense pattern of paraphilic sexual arousal, in addition to distress or
significant risk of injury or death.
• When distress related to an arousal pattern involving consenting adults or solitary
behaviour is entirely attributable to rejection or feared rejection of the arousal pattern by
others (e.g. a partner, family, society), a diagnosis of paraphilic disorder involving solitary
behaviour or consenting individuals should not be assigned. Instead, categories from the
grouping QA15 Counselling related to sexuality in Chapter 24 on factors influencing
health status or contact with health services may be considered.
• This diagnosis should not be applied to individuals who are distressed about homosexual
or bisexual sexual orientation. If an individual is presenting for treatment based on such
distress, categories from the grouping QA15 Counselling related to sexuality in Chapter 24
on factors influencing health status or contact with health services may be considered. If
the pattern of distress-related symptoms meets the diagnostic requirements for another
mental disorder (e.g. adjustment disorder, a depressive disorder, an anxiety or fear-related
disorder), that diagnosis should be assigned.
Course features
• Individuals with paraphilic arousal patterns involving solitary behaviour or consenting
individuals often report the onset of paraphilic sexual interest during adolescence.
• Paraphilic arousal patterns are relatively stable after young adulthood, but sexual thoughts,
fantasies, urges and behaviours, as well as any associated distress, may change over time,
such that an individual who was assigned a diagnosis of a paraphilic disorder involving
solitary behaviour or consenting individuals no longer meets the diagnostic requirements.
Developmental presentations
• Advancing age may be associated with decreasing paraphilic sexual arousal and decreasing
related behavioural manifestations due to increased impulse control and decreased sexual
drive.
Paraphilic disorders | Paraphilic disorder involving solitary behaviour or consenting individuals
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Paraphilic arousal patterns involving solitary behaviour or consenting individuals are
much more prevalent among men.
• Paraphilic arousal patterns involving masochism are more prevalent among women than
other paraphilic arousal patterns. If other diagnostic requirements are met (e.g. marked
distress or significant risk of injury or death), a masochistic paraphilic arousal pattern may
be a part of the basis for diagnosis of paraphilic disorder involving solitary behaviour or
consenting individuals.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with compulsive sexual behaviour disorder
Both paraphilic disorder involving solitary behaviour or consenting individuals and compulsive
sexual behaviour disorder may involve repetitive sexual impulses, urges or behaviours that result
in marked distress or impairment. Paraphilic disorder involving solitary behaviour or consenting
individuals is characterized by sexual impulses, urges or behaviours that are manifestations of
a sustained, focused and intense pattern of atypical sexual arousal that is associated with either
marked distress or significant risk of injury or death. In contrast, compulsive sexual behaviour
disorder is characterized by a persistent pattern of failure to control sexual impulses, urges or
behaviours, regardless of the focus of sexual arousal. If an individual with paraphilic disorder
involving solitary behaviour or consenting individuals is able to exercise some degree of control
over the behavioural expressions of the arousal pattern, an additional diagnosis of compulsive
sexual behavioural disorder is generally not warranted.
Boundary with disorders due to substance use
Episodes of sexual behaviour that are atypical for the individual may occur during substance
intoxication. Such episodes may not be a manifestation of a sustained, focused and intense sexual
arousal pattern. At the same time, some individuals with paraphilic disorders may use substances
with the intention of engaging atypical sexual behaviour that does reflect an underlying paraphilic
arousal pattern. A diagnosis of paraphilic disorder involving solitary behaviour or consenting
individuals may be assigned together with a disorder due to substance use if the diagnostic
requirements for both are met.
Boundary with other mental disorders in the context of rejection or feared rejection
If distress related to rejection or feared rejection of the arousal pattern by others has reached a
point that presenting symptoms meet the diagnostic requirements for another mental disorder
(e.g. adjustment disorder, a depressive disorder, an anxiety or fear-related disorder), that diagnosis
should be assigned rather than paraphilic disorder involving solitary behaviour or consenting
individuals.
Paraphilic disorders | Paraphilic disorder involving solitary behaviour or consenting individuals

20 - 6A23 Acute and transient psychotic disorder
6A23 Acute and transient psychotic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
relationships that are entirely a consequence of the symptoms of schizotypal disorder. However,
if additional personality features are present that are judged to produce significant problems in
interpersonal functioning, an additional diagnosis of personality disorder may be appropriate.
Acute and transient psychotic disorder
Essential (required) features
• Acute onset of psychotic symptoms – which can include delusions, hallucinations,
disorganized thinking or experiences of influence, passivity or control – that emerge
without a prodrome, progressing from a non-psychotic state to a clearly psychotic state
within 2 weeks, is required for diagnosis. Psychomotor disturbances may also be present,
including catatonia.
• Symptoms change rapidly, both in nature and intensity. Such changes may occur from day
to day, or even within a single day.
• Absence of negative symptoms (i.e. affective flattening, alogia or paucity of speech,
avolition, asociality, anhedonia) is evident during the psychotic episode.
• The duration of the symptoms does not exceed 3 months, and most commonly lasts from
a few days to 1 month.
• The symptoms or behaviours are not a manifestation of another medical condition (e.g.
a brain tumour), are not due to the effects of a substance or medication on the central
nervous system (e.g. corticosteroids) – including withdrawal effects (e.g. from alcohol) –
and are not better accounted for by schizophrenia or another primary psychotic disorder.
Course specifiers for acute and transient psychotic disorder
The following specifiers should be applied to identify the course of acute and transient psychotic
disorder, including whether the individual currently meets the diagnostic requirements for the
disorder or is in partial or full remission. If there have been no previous episodes of acute and
transient psychotic disorder, the corresponding single episode specifier should be applied. If there
have been multiple such episodes, the corresponding multiple episodes specifier should be applied.
Acute and transient psychotic disorder, first episode
• The first episode specifier should be applied when the current or most recent episode is the first
manifestation of acute and transient psychotic disorder meeting all diagnostic requirements
of the disorder.
6A23
6A23.0
Schizophrenia and other primary psychotic disorders | Acute and transient psychotic disorder
181
Schizophrenia and other primary psychotic disorders
Acute and transient psychotic disorder, first episode, currently symptomatic
• All diagnostic requirements for acute and transient psychotic disorder in terms of
symptoms and duration are currently met, or have been met within the past month.
• There have been no previous episodes of acute and transient psychotic disorder.
Acute and transient psychotic disorder, first episode, in partial remission
• The full diagnostic requirements for acute and transient psychotic disorder have not been
met within the past month, but some clinically significant symptoms remain, which may
or may not be associated with functional impairment.
• There have been no previous episodes of acute and transient psychotic disorder.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms
of acute and transient psychotic disorder following an asymptomatic period in a person who has
previously met the diagnostic requirements for acute and transient psychotic disorder.
Acute and transient psychotic disorder, first episode, in full remission
• The full diagnostic requirements for acute and transient psychotic disorder have not been
met within the past month, and no clinically significant symptoms remain.
• There have been no previous episodes of acute and transient psychotic disorder.
Acute and transient psychotic disorder, first episode, unspecified
Acute and transient psychotic disorder, multiple episodes
The multiple episodes specifier should be applied when there have been a minimum of two
episodes meeting all diagnostic requirements of acute and transient psychotic disorder in terms
of symptoms and duration, with a period of full remission between episodes lasting at least
3 months.
Acute and transient psychotic disorder, multiple episodes, currently symptomatic
• All diagnostic requirements for acute and transient psychotic disorder in terms of
symptoms and duration are currently met, or have been met within the past month.
• There have been a minimum of two episodes, with a period of full remission between
episodes lasting at least 3 months.
6A23.00
6A23.01
6A23.02
6A23.0Z
6A23.10
6A23.1
Schizophrenia and other primary psychotic disorders | Acute and transient psychotic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Acute and transient psychotic disorder, multiple episodes, in partial remission
• The full diagnostic requirements for acute and transient psychotic disorder have not been
met within the past month, but some clinically significant symptoms remain, which may
or may not be associated with functional impairment.
• There have been a minimum of two episodes, with a period full remission between episodes
lasting at least 3 months.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms of
acute and transient psychotic disorder following an asymptomatic period.
Acute and transient psychotic disorder, multiple episodes, in full remission
• The full diagnostic requirements for acute and transient psychotic disorder have not been
met within the past month, and no clinically significant symptoms remain.
• There have been a minimum of two episodes, with a period of full remission between
episodes lasting at least 3 months.
Acute and transient psychotic disorder, multiple episodes, unspecified
Other specified acute and transient psychotic disorder
Acute and transient psychotic disorder, unspecified
Additional clinical features
• The onset of the acute and transient psychotic disorder is usually associated with a rapid
deterioration in social and occupational functioning. Following remission, the person is
generally able to regain the premorbid level of functioning.
• There are often other symptoms such as fluctuating disturbances of mood and affect,
transient states of perplexity or confusion, or impairment of attention and concentration.
• An episode of acute stress preceding the onset of acute and transient psychotic disorder is
commonly reported, but this is not a diagnostic requirement.
• If the symptoms last for more than 3 months, a different diagnosis should be considered,
depending on the specific symptoms (e.g. schizophrenia, schizoaffective disorder,
delusional disorder, other primary psychotic disorder).
6A23.11
6A23.12
6A23.1Z
6A23.Y
6A23.Z
Schizophrenia and other primary psychotic disorders | Acute and transient psychotic disorder
183
Schizophrenia and other primary psychotic disorders
Boundary with normality (threshold)
• Isolated unusual subjective experiences, such as experiences resembling hallucinations
and delusions, are reported in the general population. However, in acute and transient
psychotic disorder, the symptoms progress rapidly to full psychosis; they are usually
polymorphic, fluctuating in quality and intensity (e.g. having features come and go in
relatively rapid succession, or having the nature of a feature change over time, such as the
focus or nature of a delusional belief); and usually fully remit within several weeks.
Course features
• Symptoms are brief in nature, lasting anywhere from a few days but not exceeding 3 months.
• Some individuals diagnosed with acute and transient psychotic disorder will go on to
meet diagnostic requirements for another mental disorder, such as schizophrenia, another
primary psychotic disorder or a mood disorder.
• In general, favourable outcomes are associated with acute onset, short duration, good
premorbid functioning and female gender.
Developmental presentations
• Onset of acute and transient psychotic disorders typically occurs between early and middle
adulthood. However, the disorder may occur during adolescence or later in the lifespan,
often following an episode of acute stress.
Culture-related features
• Migrant populations may be more likely to report these experiences. This may be due to
higher prevalence as a result of migration-related stress, misattribution of psychosis by
clinicians unfamiliar with cultural expressions of distress, or a combination of the two.
• In some cultures, distress due to social and other environmental circumstances may be
expressed in ways that can be misinterpreted as psychotic symptoms (e.g. overvalued ideas
and pseudo-hallucinations) but that instead are normative to the person’s subgroup.
Schizophrenia and other primary psychotic disorders | Acute and transient psychotic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• Acute and transient psychotic disorder is more prevalent among females.
• Male gender and younger age of acute and transient psychotic disorder onset appear to be
associated with greater risk of subsequent development of schizophrenia.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizophrenia and schizoaffective disorder
The psychotic symptoms in schizophrenia and in schizoaffective disorder last for at least 1 month
in their full, florid form and tend to be more stable or fixed (e.g. having the same delusion for a
period of months). In contrast, the symptoms in acute and transient psychotic disorder tend to
fluctuate rapidly in intensity and type across time, such that the content and focus of delusions or
hallucinations often shift, even on a daily basis. Negative symptoms may be present in schizophrenia
and schizoaffective disorder, but do not occur in acute and transient psychotic disorder. The duration
of acute and transient psychotic disorder does not exceed 3 months, and most often lasts from a few
days to 1 month, compared to a much longer typical course for schizophrenia or schizoaffective
disorder. Finally, in contrast to schizophrenia, where the onset is often preceded by a history of poor
premorbid adjustment, in acute and transient psychotic disorder the person’s symptoms progress
rapidly without a prodromal period. In cases that meet both the diagnostic requirements for acute
and transient psychotic disorder (i.e. fluctuating symptoms, acute onset, duration less than 3 months)
and schizophrenia (e.g. delusions and hallucinations for more than 1 month) in the absence of a
previous history of schizophrenia, a diagnosis of acute and transient psychotic disorder and not
schizophrenia should be assigned.
Boundary with mood disorders with psychotic symptoms
Depressive and bipolar disorders are characterized by a predominant disturbance in mood that
persists for at least several days and often much longer. Although mood symptoms may occur in
acute and transient psychotic disorder, they are transient and do not meet the required duration or
associated symptoms to qualify for a depressive, manic or mixed episode.
Boundary with acute stress reaction and dissociative disorders
Like acute and transient psychotic disorder, acute stress reaction and some dissociative disorders
have an acute onset, often in response to a stressful life experience, and resolve in days to weeks. In
contrast, by definition, acute and transient psychotic disorder includes psychotic symptoms like
hallucinations or delusions that do not occur in disorders specifically associated with stress or in
dissociative disorders.
Boundary with delirium
In delirium, the individual has a fluctuating clouding of consciousness (i.e. reduced ability to direct,
focus, sustain and shift attention) and awareness (i.e. reduced orientation to the environment). In
contrast, in acute and transient psychotic disorder, the person maintains a regular level of alertness
and relatively clear sense of consciousness, despite transient states of perplexity, confusion and
impairment of attention or concentration.
Schizophrenia and other primary psychotic disorders | Acute and transient psychotic disorder

200 - 6D3Z Paraphilic disorder, unspecified
6D3Z Paraphilic disorder, unspecified
591
Paraphilic disorders
Boundary with other mental disorders in the context of sexual behaviours that are
atypical for the individual
Sexual behaviours that are atypical for the individual that do not reflect an underlying, persistent
pattern of sexual arousal may occur in the context of some mental disorders, such as bipolar type
I disorder during manic or mixed episodes, or dementia. If the sexual behaviours involved do
not reflect an underlying, persistent pattern of sexual arousal, a diagnosis of paraphilic disorder
involving solitary behaviour or consenting individuals should not be assigned.
Boundary with gender incongruence of adolescence or adulthood
Individuals who have a focused and intense pattern of sexual arousal involving cross-dressing
might qualify for the diagnosis of paraphilic disorder involving solitary behaviour or consenting
individuals if they are markedly distressed by having this pattern of arousal. A history of sexual
excitement in association with cross-dressing can sometimes be a feature of gender incongruence
that develops in adolescence or adulthood, but such a history is not a sufficient basis for diagnosing
paraphilic disorder involving solitary behaviour or consenting individuals.
Paraphilic disorder, unspecified
6D3Z
Paraphilic disorders | Paraphilic disorder, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

201 - Factitious disorders
Factitious disorders

202 - 6D50 Factitious disorder imposed on self
6D50 Factitious disorder imposed on self
593
Factitious disorders
6D50
Factitious disorders
Factitious disorder imposed on self
Factitious disorders are characterized by feigning, falsifying or intentionally inducing or
aggravating medical, psychological or behavioural signs and symptoms or injury in oneself
or in another person associated with identified deception. A pre-existing disorder or disease
may be present, but the individual intentionally aggravates existing symptoms or falsifies or
induces additional symptoms. Individuals with factitious disorders seek treatment or otherwise
present themselves or another person as ill, injured or impaired based on the feigned, falsified
or self-induced signs, symptoms or injuries. The deceptive behaviour is not solely motivated by
obvious external rewards or incentives (e.g. obtaining disability payments or evading criminal
prosecution). This is in contrast to malingering, in which clear external rewards or incentives
motivate the behaviour.
6D51
Factitious disorder imposed on another
6D5Z
Factitious disorder, unspecified.
Factitious disorder imposed on self
Essential (required) features
• The presentation is characterized by feigning, falsifying or intentionally inducing medical,
psychological or behavioural signs and symptoms or injury associated with identified
deception. If a pre-existing disorder or disease is present, the individual intentionally
aggravates existing symptoms or falsifies or induces additional symptoms.
• The individual seeks treatment or otherwise presents themselves as ill, injured or impaired
based on the feigned, falsified or self-induced signs, symptoms or injuries.
• The deceptive behaviour is not solely motivated by obvious external rewards or incentives
(e.g. obtaining disability payments or evading criminal prosecution).
• The behaviour is not better accounted for by another mental disorder (e.g. schizophrenia
or another primary psychotic disorder).
6D50
Factitious disorders | Factitious disorder imposed on self
Factitious disorders include:
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Examples of behaviours involved in factitious disorder imposed on self include falsely
reporting or simulating episodes of neurological or mental symptoms (e.g. seizures,
hearing voices); manipulating laboratory tests to falsely indicate an abnormality (e.g.
adding sugar to urine); falsifying past or current medical records to indicate an illness;
ingesting a substance (e.g. warfarin) to produce an abnormal laboratory result or illness;
and physically injuring or intentionally inducing illness in oneself (e.g. intentional exposure
to infectious or toxic agents).
• The simulation of illness, injury or impairment and the insistence and intensity of its
presentation may be so convincing and persistent that repeated investigations or even
surgeries are performed, sometimes at many different hospitals or clinics, in spite of
repeated negative or inconclusive findings.
• The motivation for the behaviour is presumed to be psychological. Factitious disorder
imposed on self can be understood as a disorder of illness behaviour and adoption of the
sick role. Seeking attention, especially from health-care providers as a part of the sick role,
often appears to be a motivation for the behaviour.
• There is evidence that factitious disorder imposed on self in adulthood may be associated
with being the victim of factitious disorder imposed on another in childhood.
Boundary normality (threshold)
• Some individuals with medical conditions may exaggerate their symptoms in order to gain
more attention from medical professionals, family members or the community, or to gain
access to additional treatment. A diagnosis of factitious disorder imposed on self should
only be considered if there is evidence that the person is feigning, falsifying or intentionally
inducing or aggravating the symptoms.
Course features
• The typical age at identification of individuals with factitious disorder imposed on self is
30–40 years, but at the time of first assessment it is often revealed that the disorder has
been present without being detected for many years.
• There is some evidence that individuals with factitious disorder imposed on self typically
progress from less to more extreme modes of medical deception, and from an episodic to
a chronic pattern.
• Individuals with factitious disorder imposed on self often do not provide accurate histories
or access to their past medical records. As a result, systematic data regarding the onset
and development of their factitious illness behaviour and its long-term outcomes are
extremely limited.
Factitious disorders | Factitious disorder imposed on self
595
Factitious disorders
Developmental presentations
• Factitious disorder imposed on self can occur in adolescents, and has been identified in
young children.
• Among children and adolescents, commonly reported falsified or induced conditions
include fevers, ketoacidosis, rashes and infections. Methods of fabrication may include false
reporting of symptoms, self-bruising, ingestion of harmful substances and self-injections.
Sex- and/or gender-related features
• A substantial majority of individuals identified with factitious disorder imposed on self
are female.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with bodily distress disorder and hypochondriasis (health
anxiety disorder)
Individuals with bodily distress disorder or hypochondriasis may exaggerate their symptoms at
times to ensure that their care is prioritized or taken seriously, as a part of excessive attention
and treatment-seeking related to somatic symptoms. However, unlike factitious disorder imposed
on self, there is no evidence that the person is feigning, falsifying or intentionally inducing or
aggravating the symptoms.
Boundary with dissociative neurological symptom disorder
In dissociative neurological symptom disorder, symptoms (e.g. seizures, paralysis) are presented
that are not consistent with neurological findings or other pathophysiology. In contrast to
factitious disorder imposed on self, however, individuals with dissociative neurological symptom
disorder do not feign, falsify or intentionally induce their symptoms.
Boundary with malingering
In malingering, individuals also deceptively report, feign or induce symptoms in order to falsify
or exaggerate the severity of an illness. However, in malingering, primary external incentives are
considered to be motivating the behaviour. The most common external motives for malingering
include evading criminal prosecution, obtaining psychoactive medications (e.g. opioids), avoiding
military conscription or dangerous military duty, and attempting to obtain sickness or disability
benefits or improvements in living conditions such as housing. Malingering is not considered
a mental disorder and is classified in Chapter 24 on factors influencing health status or contact
with health services. In factitious disorder imposed on self, the deceptive behaviour is not solely
motivated by obvious external incentives.
Factitious disorders | Factitious disorder imposed on self

203 - 6D51 Factitious disorder imposed on another
6D51 Factitious disorder imposed on another
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with other forms of self-injurious behaviour
Individuals who exhibit self-injurious behaviour, often in the context of another mental disorder,
may intentionally provide false information to examiners regarding either the self-induced
nature of the injuries or the presence of suicidal ideation or intent. The deception in these cases is
typically intended to minimize rather than exaggerate the extent to which the individual is viewed
as ill, injured or impaired.
Factitious disorder imposed on another
Essential (required) features
• The presentation is characterized by feigning, falsifying or intentionally inducing medical,
psychological or behavioural signs and symptoms or injury in another person – most
commonly a child dependent – associated with identified deception. If a pre-existing
disorder or disease is present in the other person, the individual intentionally exaggerates
or aggravates existing symptoms, or falsifies or induces additional symptoms.
• The individual seeks treatment for the other person or otherwise presents them as ill,
injured or impaired based on the feigned, falsified or induced signs, symptoms or injuries.
• The deceptive behaviour is not solely motivated by obvious external rewards or incentives
(e.g. obtaining disability payments or avoiding criminal prosecution for child or elder
abuse).
• The behaviour is not better accounted for by another mental disorder (e.g. schizophrenia
or another primary psychotic disorder).
Note: the diagnosis of factitious disorder imposed on another is assigned to the individual who
is feigning, falsifying or inducing the symptoms in another person, not to the person who is
presented as having the symptoms. Occasionally, the individual induces or falsifies symptoms in
a pet rather than in another person.
Additional clinical features
• The range of behaviours involved in factitious disorder imposed on another is similar to
those in factitious disorder imposed on self, and includes reporting episodes of neurological
or mental symptoms in the other person; manipulating laboratory tests to falsely indicate
an abnormality (e.g. adding sugar to urine); falsifying past or current medical records
to indicate an illness; administering a substance (e.g. warfarin) to produce an abnormal
laboratory result or illness; and physically injuring or intentionally inducing illness in the
other person (e.g. intentional exposure to infectious or toxic agents).
• The simulation or induction of illness or injury in factitious disorder imposed on another
may be quite dramatic, resulting in numerous medical investigations and interventions in
spite of negative or inconclusive findings.
• The person presented as ill, injured or impaired would in many cases be considered to be
a victim of physical or psychological maltreatment (i.e. abuse), which should be classified
6D51
Factitious disorders | Factitious disorder imposed on another

204 - 6D5Z Factitious disorder, unspecified
6D5Z Factitious disorder, unspecified
597
Factitious disorders
separately using the appropriate code from Chapter 23 on external causes of morbidity
or mortality.
• There is evidence that a significant proportion of perpetrators of factitious disorder
imposed on another have a history of factitious disorder imposed on self.
Boundary with normality (threshold)
• Some individuals whose loved ones have medical conditions may exaggerate the reports
of symptoms to medical professionals in order to get their loved one’s care prioritized,
or to access additional treatments they perceive as necessary or potentially beneficial.
Factitious disorder imposed on another should only be considered if there is evidence that
the person is feigning, falsifying or intentionally inducing or aggravating the symptoms of
the other person.
Sex- and/or gender-related features
• The most common presentation of factitious disorder imposed on another is a mother who
fabricates symptoms in one or more of her children.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with motivated deception related to physical abuse
Caregivers who lie about the cause of abuse injuries in their dependents (e.g. claiming that an
injury was the result of an “accident” rather than child or elder abuse) solely in order to avoid
criminal prosecution or the intervention of child protective services should not be diagnosed with
factitious disorder imposed on another. The diagnosis of factitious disorder imposed on another
requires a clinical judgement that there are additional motivations for the deceptive behaviour,
such as obtaining the attention and admiration of health-care providers.
Boundary with mental disorders with psychotic symptoms
Individuals with other mental disorders (e.g. schizophrenia and other primary psychotic
disorders, mood disorders) may sometimes harm others, including their children, in response
to a command hallucination or a delusion, or as part of a suicide attempt. In such cases, there
is typically no evidence of deception associated with the harmful behaviour other than to
avoid criminal prosecution for child abuse or other intervention (e.g. removal of a child by
protective services).
Factitious disorder, unspecified
6D5Z
Factitious disorders | Factitious disorder, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

205 - Neurocognitive disorders
Neurocognitive disorders
599
Neurocognitive disorders
Neurocognitive disorders
Delirium
Neurocognitive disorders are characterized by primary clinical deficits in neurocognitive
functioning that are acquired rather than developmental. Neurocognitive functioning specifically
refers to neurologically based cognitive skills and abilities believed to be directly related to
brain functioning, including but not limited to attention/concentration, memory, language,
visual spatial/perceptual skills, processing speed and executive functioning (e.g. problem
solving, judgement).
Neurocognitive disorders represent a decline from a previously attained level of functioning. This
grouping does not include disorders characterized by deficits in neurocognitive functioning that
are present from birth or that typically arise during the developmental period, which are classified
in the grouping of neurodevelopmental disorders. Although cognitive deficits are present in many
mental disorders (e.g. schizophrenia, bipolar disorders), only disorders whose core features are
neurocognitive are included in the neurocognitive disorders grouping.
6D70.0
Delirium due to disease classified elsewhere
6D70.1
Delirium due to psychoactive substances, including medications
Note: The following subcategories are cross-listed from disorders due to
substance use:
6C40.5
Alcohol-induced delirium
6C41.5
Cannabis-induced delirium
6C42.5
Synthetic cannabinoid-induced delirium
6C43.5
Opioid-induced delirium
6C44.5
Sedative, hypnotic or anxiolytic-induced delirium
6C45.5
Cocaine-induced delirium
6C46.5
Stimulant-induced delirium, including amfetamines,
methamfetamine and methcathinone
6C47.5
Synthetic cathinone-induced delirium
6C49.4
Hallucinogen-induced delirium
6C4B.5
Volatile inhalant-induced delirium
6C4C.5
MDMA or related drug-induced delirium, including MDA
6C4D.4 Dissociative drug-induced delirium, including ketamine and PCP
6C4E.5
Delirium induced by other specified psychoactive substance,
including medications
6C4F.5
Delirium induced by multiple specified psychoactive substances,
including medications
Neurocognitive disorders
6D70
Neurocognitive disorders include the following:
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
6C4G.5 Delirium induced by unknown or unspecified psychoactive substances
6D70.2 Delirium due to multiple etiological factors
6D70.Y Delirium, other specified cause
6D70.Z
Delirium, unknown or unspecified cause
Mild neurocognitive disorder
Amnestic disorder
6D72.0
Amnestic disorder due to diseases classified elsewhere
6D72.1
Amnestic disorder due to psychoactive substances, including
medications
6D72.10 Amnestic disorder due to use of alcohol
6D72.11 Amnestic disorder due to use of sedatives, hypnotics or
anxiolytics
6D72.12 Amnestic disorder due to other specified psychoactive
substance, including medications
6D72.13 Amnestic disorder due to use of volatile inhalants
6D72.Y Amnestic disorder, other specified cause
6D72.Z
Amnestic disorder, unknown or unspecified cause
Dementia due to Alzheimer disease
6D80.0
Dementia due to Alzheimer disease with early onset
6D80.1 Dementia due to Alzheimer disease with late onset
6D80.2 Alzheimer disease dementia, mixed type, with cerebrovascular
disease
6D80.3 Alzheimer disease dementia, mixed type, with other nonvascular
etiologies
6D80.Z Dementia due to Alzheimer disease, onset unknown or unspecified
Dementia due to cerebrovascular disease
Dementia due to Lewy body disease
Frontotemporal dementia
Neurocognitive disorders
6D71
6D72
6D80
6D81
6D82
6D63
Dementia due to psychoactive substances, including
medications
6D84.0
Dementia due to use of alcohol
6D84.1
Dementia due to use of sedatives, hypnotics or anxiolytics
6D84.2
Dementia due to use of volatile inhalants
6D84.Y Dementia due to use of other specified psychoactive substance
6D84
601
Neurocognitive disorders
Dementia due to diseases classified elsewhere
6D85.0
Dementia due to Parkinson disease
6D85.1
Dementia due to Huntington disease
6D85.2
Dementia due to exposure to heavy metals and other toxins
6D85.3
Dementia due to HIV
6D85.4
Dementia due to multiple sclerosis
6D85.5
Dementia due to prion disease
6D85.6
Dementia due to normal-pressure hydrocephalus
6D85.7
Dementia due to injury to the head
6D85.8
Dementia due to pellagra
6D85.9
Dementia due to Down syndrome
6D85.Y Dementia due to other specified disease classified elsewhere
Dementia, other specified cause
Dementia, unknown or unspecified cause
Other specified neurocognitive disorder
Neurocognitive disorder, unspecified.
Additional categories for specific symptoms are provided in the grouping MB21 Symptoms, signs
or clinical findings involving cognition in Chapter 21 on symptoms, signs or clinical findings,
not elsewhere classified. These may be used to provide additional detail regarding a particular
presentation or to describe more transient symptoms (e.g. symptoms that are closely tied to an
underlying medical condition that are not a specific focus of intervention).
In cases where the underlying pathology and etiology for neurocognitive disorders can be
determined, the diagnosis corresponding to the identified etiology should also be assigned.
General cultural considerations for neurocognitive disorders
• Performance during clinical assessment may vary according to cultural and/or linguistic
factors. When assessing impairment in neurocognitive functioning and activities of
daily living, cultural and linguistic factors should be considered and accounted for when
possible, as in the following examples.
• Test performance may be affected by cultural biases (e.g. references in test items to
terminology or objects not common to a culture) and limitations of translation and
adaptation.
• In evaluating functioning in important everyday skills, the expectations of the individual’s
culture and social environment should be considered.
• Similarly, when determining the presence of perceived or observed cognitive change,
it is important to consider cultural variations that may exist regarding expectations or
tolerance for cognitive change. For example, some degree of memory loss or cognitive
impairment might be seen as normal in some family or social systems, and may not be
fully recognized when existing support systems are available to compensate.
6D85
6D8Y
6D8Z
6E0Y
6E0Z
Neurocognitive disorders

206 - 6D70 Delirium
6D70 Delirium
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Linguistic and cultural proficiency must also be considered when interpreting test results,
in terms of both whether the individual understood the instructions and the impact on
test performance.
• When standardized testing is utilized for determination of neurocognitive impairment, it
should be appropriately developed and normed for the population of which the individual
being tested is a member. Where appropriately normed and standardized tests are not
available, assessment of the essential features of these disorders requires greater reliance on
clinical judgement based on appropriate evidence and other quantified clinical assessment.
General considerations related to sex and/or gender for
neurocognitive disorders
• Performance on clinical assessment or standardized neuropsychological/cognitive testing
may differ according to sex and/or gender-related factors. When clinical assessment
or standardized neuropsychological/cognitive testing is utilized for determination of
memory or other neurocognitive impairment, sex and/or gender-related factors should be
considered and accounted for when possible.
Delirium
Delirium includes the following subcategories:
6D70.0 Delirium due to disease classified elsewhere
6D70.1 Delirium due to psychoactive substances, including medications
6D70.2 Delirium due to multiple etiological factors
6D70.Y Delirium, other specified cause
6D70.Z Delirium, unknown or unspecified cause.
General diagnostic requirements for delirium
Essential (required) features
• A disturbance of attention, orientation and awareness developing within a short period
of time (e.g. within hours or days), typically presenting as significant confusion or global
neurocognitive impairment, with transient symptoms that may fluctuate depending on the
underlying causal condition or etiology, is required for diagnosis.
• The disturbance represents a change from the individual’s baseline functioning.
6D70
Neurocognitive disorders | Delirium
603
Neurocognitive disorders
• Delirium may be caused by the direct physiological effects of a medical condition not
classified under mental, behavioural and neurodevelopmental disorders, by the direct
physiological effects of a substance or medication – including withdrawal – or by multiple
or unknown etiological factors.
• The symptoms are not better accounted for by a pre-existing or evolving neurocognitive
disorder (e.g. amnestic disorder, mild neurocognitive disorder, dementia) or by another
mental disorder (e.g. schizophrenia or another primary psychotic disorder, a mood
disorder, post-traumatic stress disorder, a dissociative disorder).
• When a substance or medication is present, the symptoms are in excess of those typical of
substance intoxication or substance withdrawal for that substance, although delirium can
occur as a complication of intoxication or withdrawal states (see 6D70.1 Delirium due to
psychoactive substances, including medications, below).
Additional clinical features
• In delirium, cognition is typically impaired in a global manner, such that multiple areas of
neurocognitive functioning are impaired upon assessment.
• Delirium may include impaired perception, which can manifest as illusions (i.e.
misinterpretations of sensory inputs), delusions or hallucinations.
• Delirium often includes disturbance of emotion, including anxiety symptoms, depressed
mood, irritability, fear, anger, euphoria or apathy.
• Behavioural symptoms may be present (e.g. agitation, restlessness, impulsivity).
A disturbance of the sleep-wake cycle, including reduced arousal of acute onset or total
sleep loss followed by reversal of the sleep-wake cycle, may also be present.
• The presence of a pre-existing neurocognitive disorder can increase the risk of delirium
and complicate its course.
Boundary with normality (threshold)
• Normal ageing is typically associated with some degree of cognitive change. Delirium is
differentiated from age-related cognitive changes by the sudden onset of symptoms (e.g.
within hours or days), the presence of significant confusion and/or global neurocognitive
impairment, and the transient and typically fluctuating symptom presentation.
Course features
• Onset of symptoms is typically sudden (e.g. within hours or days), with a transient and/or
fluctuating course.
• Symptoms are generally expected to remit with treatment of the underlying etiology or
elimination of the causative substance from the body.
Neurocognitive disorders | Delirium
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Developmental presentations
• Susceptibility to delirium in infancy and childhood may be greater than in early and
middle adulthood.
• In childhood, delirium may be related to febrile illnesses and certain medications
(e.g. anticholinergics).
• Older individuals are especially susceptible to delirium compared with younger adults.
Culture-related features
• Performance during clinical assessment may vary according to cultural and/or linguistic
factors. When assessing impairment in neurocognitive functioning and activities of daily
living, cultural and linguistic factors should be considered and accounted for when possible.
• When standardized neuropsychological/cognitive testing is utilized for determination of
neurocognitive impairment, performance should be measured with appropriately normed,
standardized tests. In situations where appropriately normed and standardized tests
are not available, assessment of neurocognitive functioning requires greater reliance on
clinical judgement. (See the section on general cultural considerations for neurocognitive
disorders above for additional information and examples.)
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with dementia
Delirium is differentiated from other neurocognitive disorders in that the former is characterized
by global neurocognitive impairment and confusion that have a precipitous onset, are transient,
and fluctuate depending on the underlying causal condition or etiology. Dementia is more
typically characterized by impairment in specific neurocognitive abilities, and is often progressive
and more gradual in onset. Individuals with dementia are at increased risk of delirium, and those
who develop acute disturbances in attention, orientation and awareness should be assigned an
additional diagnosis of delirium and evaluated to determine its specific etiology.
Boundary with neurocognitive impairment associated with acquired or traumatic
brain injuries
Delirium is differentiated from an acute confusional or agitated state related to acquired or
traumatic brain injuries by the absence of evidence of a preceding neurological injury or event
(e.g. traumatic brain injury, cerebral haemorrhage, stroke).
Neurocognitive disorders | Delirium
605
Neurocognitive disorders
Boundary with transient global amnesia
Unlike delirium, transient global amnesia is characterized by the presence of isolated memory
impairment alongside intact functioning in other cognitive areas (e.g. naming skills, selfidentification). Although both disorders may present with memory impairment, delirium
is frequently characterized by additional symptoms, including significant confusion, global
neurocognitive impairment, and behavioural and emotional disturbance (e.g. hallucinations,
agitation).
Boundary with factitious disorder and malingering
In factitious disorder and malingering, the neurocognitive symptoms characteristic of delirium
are consciously feigned. Feigned or induced symptoms may be – although they are not necessarily
– atypical in pattern, magnitude or course, or may be medically implausible. Individuals with
factitious disorder feign neurocognitive symptoms in order to seek attention, especially from
health-care providers, and to assume the sick role. Malingering is characterized by intentional
feigning of neurocognitive impairment for obvious external incentives (e.g. disability payments).
Boundary with schizophrenia and other primary psychotic disorder
Delirium accompanied by hallucinations and/or delusions is differentiated from schizophrenia
and other primary psychotic disorders by the absence of other characteristics of these disorders,
and by symptoms that are transient and fluctuate depending on the underlying causal condition
or etiology.
Boundary with dissociative amnesia
Selective memory deficits are present in dissociative amnesia, and may be accompanied by
confusion about identity if dissociative fugue is present. Dissociative amnesia is not characterized
by disturbances in attention or awareness, general confusion or global neurocognitive impairment,
which are features of delirium.
Delirium due to disease classified elsewhere
Essential (required) features
• All diagnostic requirements for delirium are met.
• There is evidence from the history, physical examination or laboratory findings that the
neurocognitive disturbance is caused by the direct physiological consequences of a medical
condition. This judgement depends on establishing the following.
• The medical condition is known to be capable of producing delirium.
• The course of the delirium (e.g. onset, trajectory of symptoms, response to treatment) is
consistent with causation by the medical condition.
Note: when delirium is due to a disease or condition classified elsewhere, the diagnostic code
corresponding to that disease or condition should be assigned along with delirium due to
disease classified elsewhere. If the delirium is attributed to multiple medical conditions or to a
medical condition and a substance or medication, the category 6D70.2 Delirium due to multiple
etiological factors should be used instead. This may include medications being used to manage
the medical condition.
Neurocognitive disorders | Delirium
6D70.0
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Potentially explanatory medical conditions (examples)
• Certain infectious or parasitic diseases (e.g. meningitis, viral hepatitis, sepsis)
• Diseases of liver (e.g. chronic hepatic failure, hepatic encephalopathy)
• Diseases of the circulatory system (e.g. acute myocardial infarction)
• Diseases of the nervous system (e.g. cerebral ischaemic stroke, epilepsy or seizures,
hypertensive encephalopathy)
• Diseases of the urinary system (e.g. kidney failure, urinary tract infection)
• Endocrine disorders (e.g. diabetic ketoacidosis, hyperthyroidism, hypothyroidism)
• Metabolic disorders (e.g. acidosis, disorders of urea cycle metabolism, hypoglycaemia,
hypomagnesaemia, hypo-osmolality, hyponatraemia)
• Neoplasms of the brain or central nervous system
• Nutritional disorders (e.g. vitamin B1, B3 or B12 deficiency)
Delirium due to psychoactive substances, including medications
Essential (required) features
• All diagnostic requirements for delirium are met.
• There is evidence from history, physical examination or laboratory findings that the
neurocognitive disturbance is caused by the direct physiological consequences of use of a
substance or medication. This judgement depends on establishing the following.
• The substance and the amount and duration of its use or withdrawal from the substance
is known to be capable of producing delirium.
• The course of the delirium (e.g. onset, trajectory of symptoms, eventual remission with
elimination of the substance from the body) is consistent with causation by the substance.
• The duration or severity of the symptoms is substantially in excess of the characteristic
syndrome of substance intoxication or substance withdrawal due to the specified substance.
Note: each specific substance that has been identified as contributing to the delirium should
be classified using the appropriate substance-specific category. If one or more of the categories
appearing below is diagnosed, a separate diagnosis of delirium due to psychoactive substances,
including medications, should not be assigned.
6C40.5
Alcohol-induced delirium (see Table 6.16, p. 484, for a description of delirium
associated with alcohol withdrawal)
6C41.5
Cannabis-induced delirium
6C42.5
Synthetic cannabinoid-induced delirium
6C43.5
Opioid-induced delirium
6C44.5
Sedative, hypnotic or anxiolytic-induced delirium (see Table 6.16, p. 484,
for a description of delirium associated with sedative, hypnotic or anxiolytic
withdrawal)
Neurocognitive disorders | Delirium
6D70.1
607
Neurocognitive disorders
6C45.5
Cocaine-induced delirium
6C46.5
Stimulant-induced delirium, including amfetamines, methamfetamine and
methcathinone
6C47.5
Synthetic cathinone-induced delirium
6C49.4
Hallucinogen-induced delirium
6C4B.5
Volatile inhalant-induced delirium
6C4C.5
MDMA or related drug-induced delirium, including MDA
6C4D.4
Dissociative drug-induced delirium, including ketamine and PCP
6C4E.5
Delirium induced by other specified psychoactive substance, including
medications
6C4F.5
Delirium induced by multiple specified psychoactive substances, including
medications
6C4G.5
Delirium induced by unknown or unspecified psychoactive substance
A diagnosis corresponding to the pattern of use of the relevant psychoactive substance (e.g.
episode of harmful psychoactive substance use, harmful pattern of psychoactive substance use,
substance dependence) may also be assigned.
If the delirium is attributed to a substance or medication together with one or more medical
conditions, the category 6D70.2 Delirium due to multiple etiological factors should be used
instead. This may include medications being used to manage the medical condition.
Delirium due to multiple etiological factors
Essential (required) features
• All diagnostic requirements for delirium are met.
• There is evidence from the history, physical examination or laboratory findings that the
delirium is caused by either:
• the direct physiological consequences of multiple diseases classified elsewhere; or
• one or more diseases classified elsewhere and the direct effects of a substance or medication
on the central nervous system.
• This judgement depends on establishing the following.
• The medical conditions are known to be capable of producing delirium.
• If applicable, the amount and duration of use of the substance or withdrawal from the
substance is known to be capable of producing delirium.
• If applicable, the duration or severity of the symptoms is substantially in excess of the
characteristic syndrome of substance intoxication or substance withdrawal due to the
specified substance.
• The course of the delirium (e.g. onset, trajectory of symptoms, eventual remission with
elimination of the substance from the body) is consistent with causation by the medical
conditions and, if applicable, the substance.
Note: when delirium is related to one or more diseases or conditions classified elsewhere, the
diagnostic code corresponding to those diseases or conditions should be assigned along with
delirium due to multiple etiological factors.
Neurocognitive disorders | Delirium
6D70.2

207 - 6D71 Mild neurocognitive disorder
6D71 Mild neurocognitive disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Delirium, other specified cause
Essential (required) features
• All diagnostic requirements for delirium are met.
• The delirium is presumed to be attributable to an identified cause that is not adequately
captured by any of the other available delirium categories.
• This judgement depends on establishing the following:
• The specified cause is known to be capable of producing delirium.
• The course of the delirium (e.g. onset, trajectory of symptoms, response to treatment) is
consistent with the specified cause.
Note: the ICD-11 diagnosis corresponding to the presumed etiology should also be assigned.
Delirium, unknown or unspecified cause
Mild neurocognitive disorder
Essential (required) features
• The presence of mild impairment in one more or cognitive domains (e.g. attention,
executive function, language, memory, perceptual-motor abilities, social cognition)
relative to expectations for age and general premorbid level of neurocognitive functioning
is required for diagnosis.
• Impairment represents a decline from the individual’s previous level of functioning.
• Neurocognitive impairment is not severe enough to interfere significantly with an
individual’s ability to perform activities related to personal, family, social, educational and/
or occupational functioning or other important functional areas.
• Evidence of mild neurocognitive impairment is based on:
• information obtained from the individual, an informant or clinical observation;
• objective evidence of impairment as demonstrated by standardized neuropsychological/
cognitive testing or, in its absence, another quantified clinical assessment.
• Neurocognitive impairment is not attributable to normal ageing.
• Neurocognitive impairment may be attributable to an underlying acquired disease of the
nervous system, a trauma, an infection or other disease process affecting the brain, use
of specific substances or medications, nutritional deficiency or exposure to toxins, or the
etiology may be undetermined.
6D70.Y
Neurocognitive disorders | Mild neurocognitive disorder
6D70.Z
6D71
609
Neurocognitive disorders
• The symptoms are not better explained by another neurocognitive disorder, substance
intoxication or substance withdrawal, or another mental disorder (e.g. attention
deficit hyperactivity disorder or other neurodevelopmental disorder, schizophrenia or
another primary psychotic disorder, a mood disorder, post-traumatic stress disorder, a
dissociative disorder).
Note: cases referred to elsewhere as “mild cognitive impairment” are referred to in ICD-11
as “mild neurocognitive disorder”. When mild neurocognitive disorder is due to a disease,
condition or injury classified elsewhere (including disorders due to substance use), the diagnostic
code corresponding to that disease, condition or injury should assigned in addition to mild
neurocognitive disorder. When the etiological condition is unknown, the diagnosis 8A2Z
Disorders with neurocognitive impairment as a major feature, unspecified, may be assigned
in addition to mild neurocognitive disorder.
Potentially explanatory medical conditions (examples)
Mild neurocognitive disorder may be caused by any of the specified causes of dementia (see
specific types of dementia, p. 621). In addition, mild neurocognitive disorder may be caused by:
• anaemias or other erythrocyte disorders;
• certain infectious or parasitic diseases (e.g. meningitis);
• diseases of the circulatory system (e.g. coronary atherosclerosis);
• diseases of the nervous system (e.g. cerebral palsy, epilepsy or seizures, hypertensive
encephalopathy, hypoxic-ischaemic encephalopathy);
• endocrine diseases (e.g. diabetes mellitus, hypothyroidism);
• intracranial injury;
• metabolic disorders (e.g. hypo-osmolality or hyponatraemia);
• neoplasms of the brain or central nervous system;
• nutritional disorders (e.g. vitamin B12 deficiency).
Additional clinical features
• Mild declines in complex activities may be typically present (e.g. using transportation, meal
preparation), while basic activities of daily living (e.g. dressing, bathing) are preserved. The
individual may engage in compensatory strategies to maintain independence in everyday
functioning.
• Behavioural and psychological symptoms are commonly associated with mild
neurocognitive disorder (e.g. depressed mood, sleep disturbance, anxiety).
Neurocognitive disorders | Mild neurocognitive disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• Normal ageing is typically associated with some degree of cognitive change. A diagnosis
of mild neurocognitive disorder does not apply if performance is consistent with
expectations for the individual’s age, based on age-related norms for performance on
standardized assessment.
Course features
• The course of neurocognitive impairment in mild neurocognitive disorder may be static
or progressive, or may resolve or improve depending on the specific etiology and available
treatment options.
• In some cases, mild neurocognitive disorder may represent an early presentation of an
underlying disease of the nervous system that may later meet the diagnostic requirements
for dementia.
Developmental presentations
• Mild neurocognitive disorder can occur at any point across the lifespan, with
risk and prevalence depending on the underlying etiology. Overall risk of mild
neurocognitive disorder increases with age because of the increased prevalence of possible
causal conditions.
Culture-related features
• Performance during clinical assessment may vary according to cultural and/or linguistic
factors. When assessing impairment in neurocognitive functioning and activities of
daily living, cultural and linguistic factors should be considered and accounted for when
possible.
• When standardized neuropsychological/cognitive testing is utilized for determination of
neurocognitive impairment, performance should be measured with appropriately normed,
standardized tests. In situations where appropriately normed and standardized tests
are not available, assessment of neurocognitive functioning requires greater reliance on
clinical judgement. (See the section on general cultural considerations for neurocognitive
disorders above for additional information and examples.)
Neurocognitive disorders | Mild neurocognitive disorder
611
Neurocognitive disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with delirium
Delirium is characterized by a disturbance of attention, orientation and awareness, with transient
symptoms that may fluctuate depending on the underlying causal condition or etiology. Delirium
typically presents with significant confusion or global neurocognitive impairment, in contrast
to mild neurocognitive disorder, in which there is mild impairment in one or more cognitive
domains that does not interfere significantly with functioning.
Boundary with amnestic disorder
Amnestic disorder is characterized by prominent memory impairment relative to expectations
for age and general premorbid level of neurocognitive functioning that is severe enough to
result in significant impairment in personal, family, social, educational, occupational or other
important areas of functioning, in the absence of other significant neurocognitive impairment.
While specific presentations of mild neurocognitive disorder may primarily affect memory, the
memory impairment is not severe enough to interfere significantly with functioning in everyday
skills and tasks.
Boundary with dementia
Dementia is characterized by marked impairment in two or more cognitive domains that is severe
enough to cause significant impairment in personal, family, social, educational, occupational or
other important areas of functioning. Neurocognitive deficits in mild neurocognitive disorder
may be in similar areas, but are not severe enough to cause significant impairment in functioning.
Boundary with mild cognitive symptoms in other mental disorders
Mild cognitive symptoms may be a characteristic or associated feature of a wide range of mental
disorders (e.g. attention deficit hyperactivity disorder, schizophrenia and other primary psychotic
disorders, mood disorders, anxiety and fear-related disorders, post-traumatic stress disorder,
dissociative disorders). If the neurocognitive impairment is better explained by another mental
disorder, an additional diagnosis of mild neurocognitive disorder should not be assigned.
Boundary with sleep-wake disorders
Memory and other neurocognitive impairment is frequently reported by individuals with sleep
disturbance or sleep-wake disorders, such as insomnia and sleep apnoea. If the neurocognitive
impairment is better explained by a sleep-wake disorder, an additional diagnosis of mild
neurocognitive disorder should not be assigned.
Neurocognitive disorders | Mild neurocognitive disorder

208 - 6D72 Amnestic disorder
6D72 Amnestic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Amnestic disorder
Amnestic disorder includes the following subcategories:
6D72.0 Amnestic disorder due to diseases classified elsewhere
6D72.1 Amnestic disorder due to psychoactive substances, including medications
6D72.10 Amnestic disorder due to use of alcohol
6D72.11 Amnestic disorder due to use of sedatives, hypnotics or
anxiolytics
6D72.12 Amnestic disorder due to other specific psychoactive
substances, including medications
6D72.13 Amnestic disorder due to use of volatile inhalants
6D72.Y Amnestic disorder, other specified cause
6D72.Z Amnestic disorder, unknown or unspecified cause.
General diagnostic requirements for amnestic disorder
Essential (required) features
• Prominent memory impairment relative to expectations for age and general level of
premorbid neurocognitive functioning, in the absence of other significant neurocognitive
impairment, is required for diagnosis.
• The memory impairment represents a marked decline from previous levels of functioning.
• The memory impairment is characterized by reduced ability to acquire, learn and/or retain
new information.
• Evidence of memory impairment is based on:
• information obtained from the individual, an informant or clinical observation;
• substantial impairment in memory performance as demonstrated by standardized
neuropsychological/cognitive testing or, in its absence, another quantified clinical
assessment.
• The symptoms are not better accounted for by disturbance of consciousness, altered mental
status, transient global amnesia (i.e. memory impairment lasting no more than 48 hours,
with most cases resolving within 6 hours), delirium, dementia, substance intoxication,
substance withdrawal or another mental disorder (e.g. schizophrenia or another primary
psychotic disorder, a mood disorder, post-traumatic stress disorder, a dissociative disorder).
• The symptoms result in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning. In mild cases, if functioning is
maintained, it is only through significant additional effort (e.g. compensatory strategies).
6D72
Neurocognitive disorders | Amnestic disorder
613
Neurocognitive disorders
Note: when amnestic disorder is due to a disease, condition or injury classified elsewhere
(including disorders due to substance use), the diagnostic code corresponding to that disease,
condition or injury should assigned along with amnestic disorder. When the etiological condition
is unknown, the diagnosis 8A2Z Disorders with neurocognitive impairment as a major feature,
unspecified, may be assigned in addition to amnestic disorder.
Additional clinical features
• Amnestic disorder may or may not include the inability to recall previously learned
information. Recent memory is typically more impaired than remote memory, and the
ability to recall a limited amount of information immediately is usually relatively preserved.
• Standardized neuropsychological/cognitive testing or quantified clinical assessment may
be needed to determine the magnitude and pattern of other neurocognitive impairments,
and to differentiate amnestic disorder from other neurocognitive disorders (e.g. dementia).
• Subjective reports by the affected individual of impairments in learning, memory or
recall do not always correspond to objective or measurable impairment in these areas
because of potential alteration in the individual’s awareness, misperceptions of abilities,
or misattribution of the cause/source of symptoms or problems. Similarly, it is possible
that individuals with altered awareness of deficits may not acknowledge or report memory
impairments that are present.
• If standardized neuropsychological/cognitive testing or quantified clinical assessment is
not available, the symptom code MB21.1Z Amnesia, unspecified, may be used provisionally
until a quantified assessment can be conducted.
Boundary with normality (threshold)
• Normal ageing is typically associated with some degree of memory change. A diagnosis
of amnestic disorder does not apply if performance is consistent with expectations for the
individual’s age, based on age-related norms for performance on standardized assessment.
• When memory difficulties consistent with normal ageing are present and clinically
relevant, the symptom code MB21.0 Age-associated cognitive decline may be used.
Course features
• Onset of symptoms can be sudden (e.g. when due to stroke or trauma) or gradual (e.g.
when due to psychoactive substances or nutritional deficiencies).
Neurocognitive disorders | Amnestic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Symptoms may be relatively stable over time or progressive, depending on the underlying
causal condition or etiology. In some cases, symptoms may improve over time, depending
on the specific etiology and available treatment options.
• When memory impairment worsens progressively over time (e.g. due to an underlying
disease of the nervous system), amnestic disorder may represent a prodrome for dementia.
Culture-related features
• Performance during clinical assessment may vary according to cultural and/or linguistic
factors. When assessing impairment in neurocognitive functioning and activities of
daily living, cultural and linguistic factors should be considered and accounted for
when possible.
• When standardized neuropsychological/cognitive testing is utilized for determination of
neurocognitive impairment, performance should be measured with appropriately normed,
standardized tests. In situations where appropriately normed and standardized tests
are not available, assessment of neurocognitive functioning requires greater reliance on
clinical judgement. (See the section on general cultural considerations for neurocognitive
disorders above for additional information and examples.)
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with delirium
Although delirium often includes memory impairment, it is differentiated from amnestic disorder
by the presence of disturbances in attention, orientation and awareness, and significant confusion
or global neurocognitive impairment, in contrast to the specific and prominent memory
impairment seen in amnestic disorder.
Boundary with mild neurocognitive disorder
Unlike amnestic disorder, mild neurocognitive disorder is characterized by a mild level of
neurocognitive decline, with little or no impairment in functioning of everyday skills and tasks.
In mild neurocognitive disorder, symptoms are not typically restricted to memory impairment.
Boundary with dementia
Amnestic disorder is characterized by prominent memory impairment relative to expectations for
age and general level of premorbid neurocognitive functioning, in the absence of other significant
neurocognitive impairment. In contrast, dementia is characterized by impairment in two or more
cognitive domains, which frequently but not always include memory.
Boundary with dissociative amnesia
Amnestic disorder is characterized by selective and prominent impairment in the ability to learn
and remember new information, usually with relative sparing of memory for previously learned
Neurocognitive disorders | Amnestic disorder
615
Neurocognitive disorders
information and past events and experiences. In contrast, dissociative amnesia is characterized by
inability to recall important autobiographical memories – typically of recent traumatic or stressful
events – that is inconsistent with ordinary forgetting, and is often preceded by an emotional
stressor, conflict or trauma.
Boundary with memory symptoms in other mental disorders
Memory impairment may be a presenting feature other mental disorders (e.g. schizophrenia, mood
disorders, post-traumatic stress disorder, dissociative disorders). If the memory impairment is
better explained by another mental disorder, an additional diagnosis of amnestic disorder should
not be assigned.
Boundary with transient global amnesia
In transient global amnesia the memory impairment is temporary (i.e. lasting no longer than
48 hours, with most cases resolving within 6 hours) whereas in amnestic disorder memory
impairment is persistent, although in some cases it may improve with treatment, depending on
the etiology.
Amnestic disorder due to diseases classified elsewhere
Essential (required) features
• All diagnostic requirements for amnestic disorder are met.
• There is evidence from history, physical examination or laboratory findings that symptoms
are caused by the direct physiological consequences of a medical condition (e.g. a disease
of the nervous system, a traumatic brain injury, an infection, a tumour, another disease
process affecting areas of the brain involved in memory). This judgement depends on
establishing the following.
• The medical condition is known to be capable of producing memory impairment.
• The course of the memory impairment (e.g. onset, trajectory of symptoms, response to
treatment) is consistent with causation by the medical condition.
Note: when amnestic disorder is due to a disease, condition or injury classified elsewhere
(including disorders due to substance use), the diagnostic code corresponding to that disease,
condition or injury should assigned along with amnestic disorder. When the etiological condition
is unknown, the diagnosis 8A2Z Disorders with neurocognitive impairment as a major feature,
unspecified, may be assigned in addition to amnestic disorder.
Potentially explanatory medical conditions (examples)
• Anaemias or other erythrocyte disorders
• Certain infectious or parasitic diseases (e.g. meningitis)
• Diseases of the nervous system (e.g. cerebral ischaemic stroke, cerebral palsy, epilepsy or
seizures, hypoxic-ischaemic encephalopathy)
Neurocognitive disorders | Amnestic disorder
6D72.0
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Endocrine diseases (e.g. hypothyroidism)
• Intracranial injury
• Metabolic disorders (e.g. hypo-osmolality or hyponatraemia)
• Neoplasms of the brain or central nervous system
• Nutritional disorders (e.g. vitamin B1 or B12 deficiency)
Amnestic disorder due to psychoactive substances, including medications
Essential (required) features
• All diagnostic requirements for amnestic disorder are met.
• There is evidence from history, physical examination or laboratory findings that the
disturbance is caused by the direct physiological consequences of use of a substance or
medication that persists beyond the usual duration of substance intoxication or substance
withdrawal. This judgement depends on establishing the following.
• The substance or medication and the amount and duration of its use is known to be
capable of producing the memory disturbance.
• The course of the memory disturbance (e.g. onset, trajectory of symptoms, response to
treatment) is consistent with causation by the substance or medication.  
Note: if the specific substance inducing the amnestic disorder has been identified, it should be
classified using the appropriate subcategory:
6D72.10
Amnestic disorder due to use of alcohol
6D72.11
Amnestic disorder due to use of sedatives, hypnotics or anxiolytics
6D72.12
Amnestic disorder due to other specific psychoactive substances, including
medications
6D72.13
Amnestic disorder due to use of volatile inhalants.
A diagnosis corresponding to the pattern of use of the relevant psychoactive substance (e.g.
episode of harmful psychoactive substance use, harmful pattern of psychoactive substance use,
substance dependence) may also be assigned.
Note: the order of the categories under 6D72.1 Amnestic disorder due to psychoactive substances,
including medications, is different from that of other parallel entities (e.g. substance-induced
dementia, below), in which the “other specified” category is listed last. This difference is not
meaningful; the categories should be used in the same way.
Amnestic disorder, other specified cause
Essential (required) features
• All diagnostic requirements for amnestic disorder are met.
• The amnestic disorder is presumed to be attributable to an identified cause that is not
adequately captured by any of the other available amnestic disorder categories.
Neurocognitive disorders | Amnestic disorder
6D72.1
6D72.Y

209 - Dementia
Dementia
617
Neurocognitive disorders
• This judgement depends on establishing the following.
• The specified cause is known to be capable of producing amnestic disorder.
• The course of the amnestic disorder (e.g. onset, trajectory of symptoms, response to
treatment) is consistent with the specified cause.
Amnestic disorder, unknown or unspecified cause
Dementia
Dementia includes the following categories:
6D80 Dementia due to Alzheimer disease
6D80.0 Dementia due to Alzheimer disease with early onset
6D80.1 Dementia due to Alzheimer disease with late onset
6D80.2 Alzheimer disease dementia, mixed type, with cerebrovascular disease
6D80.3 Alzheimer disease dementia, mixed type, with other nonvascular
etiologies
6D80.Z Dementia due to Alzheimer disease, onset unknown or unspecified
6D81 Dementia due to cerebrovascular disease
6D82 Dementia due to Lewy body disease
6D83 Frontotemporal dementia
6D84 Dementia due to psychoactive substances, including medications
6D84.0 Dementia due to use of alcohol
6D84.1 Dementia due to use of sedatives, hypnotics or anxiolytics
6D84.2 Dementia due to use of volatile inhalants
6D84.Y Dementia due to other specified psychoactive substance
6D85 Dementia due to diseases classified elsewhere
6D85.0 Dementia due to Parkinson disease
6D85.1 Dementia due to Huntington disease
6D85.2 Dementia due to exposure to heavy metals and other toxins
6D85.3 Dementia due to HIV
6D85.4 Dementia due to multiple sclerosis
6D85.5 Dementia due to prion disease
6D85.6 Dementia due to normal-pressure hydrocephalus
6D85.7 Dementia due to injury to the head
6D85.8 Dementia due to pellagra
6D85.9 Dementia due to Down syndrome
6D85.Y Dementia due to other specified disease classified elsewhere
6D8Y Dementia, other specified cause
6D8Z Dementia, unknown or unspecified cause.
Neurocognitive disorders | Dementia
6D72.Z

21 - 6A24 Delusional disorder
6A24 Delusional disorder
185
Schizophrenia and other primary psychotic disorders
Delusional disorder
Essential (required) features
• The presence of a delusion or set of related delusions, typically persisting for at least
3 months and often much longer, in the absence of a depressive, manic or mixed episode
is required for diagnosis.
• The delusions are variable in content across individuals, while showing remarkable stability
within individuals, although they may evolve over time. Common forms of delusions
include persecutory, somatic (e.g. a belief that organs are rotting or malfunctioning despite
normal medical examination), grandiose (e.g. a belief that one has discovered an elixir that
gives eternal life), jealous (e.g. the unjustified belief that one’s spouse is unfaithful) and
erotomanic (i.e. the belief that another person, usually a famous or high-status stranger, is
in love with the person experiencing the delusion).
• Absence of clear and persistent hallucinations; severely disorganized thinking (formal
thought disorder); experiences of influence, passivity or control; or negative symptoms
characteristic of schizophrenia is evident. However, in some cases, specific hallucinations
typically related to the content of the delusions may be present (e.g. tactile hallucinations
in delusions of being infected by parasites or insects).
• Apart from the actions and attitudes directly related to the delusional system, affect, speech
and behaviour are typically unaffected.
• The symptoms are not a manifestation of another medical condition (e.g. a brain tumour),
are not due to the effects of a substance or medication on the central nervous system (e.g.
corticosteroids) – including withdrawal effects (e.g. from alcohol) – and are not better
accounted for by another mental disorder (e.g. another primary psychotic disorder, a mood
disorder, an obsessive-compulsive or related disorder, an eating disorder).
Course specifiers for delusional disorder
The following specifiers should be applied to identify whether the individual currently meets the
diagnostic requirements of delusional disorder or is in partial or full remission.
Delusional disorder, currently symptomatic
• All diagnostic requirements for delusional disorder in terms of symptoms and duration are
currently met, or have been met within the past month.
6A24
6A24.0
Schizophrenia and other primary psychotic disorders | Delusional disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Delusional disorder, in partial remission
• The full diagnostic requirements for delusional disorder have not been met within the
past month, but some clinically significant symptoms remain, which may or may not be
associated with functional impairment.
Note: this category may also be used to designate the re-emergence of subthreshold symptoms
of delusional disorder following an asymptomatic period in a person who has previously met the
diagnostic requirements for delusional disorder.
Delusional disorder, in full remission
• The full diagnostic requirements for delusional disorder have not been met within the past
month, and no clinically significant symptoms remain.
Delusional disorder, unspecified
Additional clinical features
• Delusions may be accompanied by actions directly related to the content of the
delusions – for example, stalking the loved person in the context of erotomania or filing
lawsuits against those believed to be persecuting the person.
• Rarely, delusional disorder may occur at the same time (or closely associated in time) in
two people who have a strong emotional or situational link. This condition is often referred
to as “shared or induced delusional disorder” or “folie-à-deux”. In such cases, one person
typically adopts the delusional belief of the other person, and the delusions may remit in
the less dominant person when the two individuals are separated.
Boundary with normality (threshold)
• A continuum of delusional beliefs, attenuated delusional beliefs, overvalued ideas, and
unusual or eccentric beliefs has been observed in the general population. Such beliefs may
be more common among people under conditions of adversity. People with delusional
disorder may display greater psychological distress, greater preoccupation and a higher
degree of conviction compared to people in the general population with beliefs that are
similar in nature to beliefs that could be characterized as delusional.
6A24.1
6A24.2
6A24.Z
Schizophrenia and other primary psychotic disorders | Delusional disorder
187
Schizophrenia and other primary psychotic disorders
Course features
• Delusional disorder typically has a later onset and greater stability of symptoms than other
psychotic disorders with delusional symptoms.
• Some individuals with delusional disorder will develop schizophrenia.
• Individuals are more likely to have a premorbid personality disorder prior to the onset of
delusional disorder.
• Levels of functioning are typically better among individuals with delusional disorder
compared to those with a diagnosis of schizophrenia or another primary psychotic disorder.
• Individuals with delusional disorder are less likely to require hospitalization in comparison
to individuals with either schizophrenia or schizoaffective disorder.
Developmental presentations
• Delusional disorder is more prevalent among older individuals.
• Individuals who experience delusional disorder in early adulthood are more likely to have
a history of hallucinations and severe psychopathology during adolescence.
Culture-related features
• Cultural factors may influence the presentation and diagnosis of delusional disorder.
For example, spirit possession or witchcraft beliefs may be normative in some but not
other cultures.
• Individuals may present with a combination of delusions and overvalued ideas, both
drawing on similar cultural idioms and beliefs.
• Diverse populations that experience persecution (e.g. torture, political violence,
discrimination due to minority status) may report fears that may be misjudged as paranoid
delusions; these may represent instead appropriate fears of recurrence of being persecuted
or symptoms of co-occurring post-traumatic stress disorder. Accurate diagnosis relies
on obtaining historical information and considering the cultural context to discern the
veracity of persecutory beliefs.
Schizophrenia and other primary psychotic disorders | Delusional disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sex- and/or gender-related features
• There are no prominent gender differences in delusional disorder. However, males appear
to have a younger age of onset and are more likely to have delusions of jealousy.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizophrenia
Both schizophrenia and delusional disorder may be characterized by persistent delusions. If other
features are present that meet the diagnostic requirements for schizophrenia (i.e. persistent
hallucinations, disorganized thinking, negative symptoms, disorganized or abnormal psychomotor
behaviour, or experiences of influence, passivity or control), a diagnosis of schizophrenia may be
made instead of a diagnosis of delusional disorder. However, hallucinations that are consistent with
the content of the delusions and do not occur persistently (i.e. with regular frequency for 1 month or
longer) are consistent with a diagnosis of delusional disorder rather than schizophrenia. Delusional
disorder is generally characterized by relatively preserved personality and less deterioration and
impairment in social and occupational functioning than schizophrenia, and individuals with
delusional disorder tend to present for the first time at a later age. Individuals with symptom
presentations consistent with delusional disorder (e.g. delusions and related, circumscribed
hallucinations) but who have not met the minimum duration requirement of 3 months should
not be assigned a diagnosis of schizophrenia, even though the combination of persistent delusions
and related hallucinations technically meets diagnostic requirements for schizophrenia. Instead,
a diagnosis of other specified primary psychotic disorder is more appropriate in such cases.
Boundary with mood disorders with psychotic symptoms
In depressive disorders with psychotic symptoms and bipolar disorders with psychotic symptoms,
delusions may present during the course of the mood episodes. Although mood symptoms –
especially depressed mood – can occur in delusional disorder, the diagnosis of delusional disorder
requires that there are times when the person experiences the delusions in the absence of any
mood disturbance.
Boundary with obsessive-compulsive disorder, body dysmorphic disorder,
hypochondriasis (health anxiety disorder), olfactory reference disorder and
anorexia nervosa
A number of mental disorders (e.g. obsessive-compulsive disorder, body dysmorphic disorder,
hypochondriasis, olfactory reference disorder, anorexia nervosa) may involve a recurrent
preoccupation with a belief that is demonstrably untrue or that is not shared by others (e.g. that
ritualistically washing one’s hands prevents harm to loved ones, that a body part is defective, that
one has a serious medical illness, that one emits a foul smell, that one is overweight) that may at
times appear to be delusional in intensity, in the context of the other clinical features of that disorder.
An additional diagnosis of delusional disorder should not be given if the belief occurs entirely in
the context of symptomatic episodes of one of these other disorders and is fully consistent with its
other clinical features.
Schizophrenia and other primary psychotic disorders | Delusional disorder

210 - General diagnostic requirements for dementia
General diagnostic requirements for dementia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
This section begins by providing the general diagnostic requirements for dementia, which are
applicable to all forms of dementia. Next, additional information is provided about the diagnostic
requirements for each of the specific types of dementia.
Each of the dementia categories may be described as mild, moderate or severe. The general CDDR
for dementia also provide guidance on applying each level of the severity specifier:
XS5W
Mild
XS0T
Moderate
XS25
Severe
Specifiers are also provided for behavioural or psychological disturbances in dementia that may
be used when these are severe enough to represent a focus of clinical intervention. These specifiers
are also described below as part of the general CDDR for dementia. As many behavioural or
psychological disturbances specifiers may be applied as necessary to describe the current clinical
picture. These specifiers may be applied to all dementia categories. They include:
6D86.0 Psychotic symptoms in dementia
6D86.1 Mood symptoms in dementia
6D86.2 Anxiety symptoms in dementia
6D86.3 Apathy in dementia
6D86.4 Agitation or aggression in dementia
6D86.5 Disinhibition in dementia
6D86.6 Wandering in dementia
6D86.Y Other specified behavioural or psychological disturbance in dementia
6D86.Z Behavioural or psychological disturbance in dementia, unspecified.
General diagnostic requirements for dementia
Essential (required) features
• Marked impairment in two or more cognitive domains relative to the level expected given
the individual’s age and general premorbid level of neurocognitive functioning, which
represents a decline from the individual’s previous level of functioning, is required for
diagnosis.
• Memory impairment is present in most forms of dementia, but neurocognitive impairment
is not restricted to memory and may be present in other cognitive domains such as
executive functioning, attention, language, social cognition and judgement, psychomotor
speed, and visuoperceptual or visuospatial functioning.
• Evidence of neurocognitive impairment is based on:
• information obtained from the individual, an informant or clinical observation;
• substantial impairment in neurocognitive performance as demonstrated by standardized
neuropsychological/cognitive testing or, in its absence, another quantified clinical
assessment.
• Behavioural changes (e.g. changes in personality, disinhibition, agitation, irritability) may
also be present and, in some forms of dementia, may be the presenting symptom.
Neurocognitive disorders | Dementia
619
Neurocognitive disorders
Additional clinical features for dementia
• Symptom course may provide information about the etiology of dementia (see the
descriptions below of dementia due to specific etiologies). Most dementias are progressive
(e.g. dementia due to Alzheimer disease, dementia due to Lewy body disease, frontotemporal
dementia), whereas other forms are reversible (e.g. dementia related to nutritional or
metabolic abnormalities), stable (e.g. some cases of dementia due to cerebrovascular
disease) or rapidly progressing (e.g. dementia due to prion disease).
Boundary with normality (threshold) for dementia
• Normal ageing is typically associated with some degree of cognitive change. Dementia
is differentiated from normal ageing by the severity or magnitude of neurocognitive
impairment relative to expectations for age, and by functional impairment in everyday skills
and tasks. Deviation from normal ageing can be determined by standardized assessment
using appropriately normed measures. When cognitive difficulties consistent with normal
ageing are present and clinically relevant, the symptom code MB21.0 Age-associated
cognitive decline may be used.
Course features for dementia
• Onset and course of symptoms varies considerably by dementia etiology. (See additional
information below regarding symptom onset and course for dementia due to specific
etiologies.)
Developmental presentations for dementia
• Dementia in children or young adults is rare, and often caused by neuronal ceroid
lipofuscinoses, a group of lysosomal storage disorders.
• Dementia due to Down syndrome occurs in about 50% or more of individuals with Down
syndrome, and typically emerges after the fourth decade of life.
• Risk of dementia increases in older adulthood.
Neurocognitive disorders | Dementia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Culture-related features for dementia
• Performance during clinical assessment may vary according to cultural and/or linguistic
factors. When assessing impairment in neurocognitive functioning and activities of daily
living, cultural and linguistic factors should be considered and accounted for when possible.
• When standardized neuropsychological/cognitive testing is utilized for determination of
neurocognitive impairment, performance should be measured with appropriately normed,
standardized tests. In situations where appropriately normed and standardized tests are
not available, assessment of neurocognitive functioning requires greater reliance on
clinical judgement. (See the section on general cultural considerations for neurocognitive
disorders above for additional information and examples.)
Boundaries with other disorders and conditions (differential
diagnosis) for dementia
Boundary with delirium
Delirium is differentiated from dementia in that delirium is characterized by global neurocognitive
impairment and confusion that have a precipitous onset, are transient, and fluctuate depending
on the underlying causal condition or etiology. Dementia is more typically characterized by
impairment in specific cognitive skills, and is often progressive and more gradual in onset.
Individuals with dementia are at increased risk of delirium, and those who develop acute
disturbances in attention, orientation and awareness should be assigned an additional diagnosis
of delirium and evaluated to determine its specific etiology.
Boundary with mild neurocognitive disorder
Dementia is characterized by marked impairment in two or more cognitive domains that is severe
enough to cause significant impairment in personal, family, social, educational, occupational or
other important areas of functioning. Neurocognitive deficits in mild neurocognitive disorder
may be in similar cognitive domains, but are not severe enough to cause significant impairment
in functioning.
Boundary with amnestic disorder
Amnestic disorder is characterized by prominent memory impairment relative to expectations for
age and general level of premorbid neurocognitive functioning, in the absence of other significant
neurocognitive impairment. In contrast, dementia is characterized by impairment in two or more
cognitive domains, which often but not invariably include memory.
Boundary with disorders of intellectual development
Disorders of intellectual development are characterized by significant limitations in both
intellectual functioning and adaptive behaviour, with onset during the developmental period.
By convention, cases that meet the diagnostic requirements for disorders of intellectual
development are diagnosed as such unless the neurocognitive impairments are known to be caused
by an etiology that is specifically associated with dementia, in which case the dementia diagnosis
Neurocognitive disorders | Dementia

211 - Specific types of dementia
Specific types of dementia

212 - 6D80 Dementia due to Alzheimer disease
6D80 Dementia due to Alzheimer disease
621
Neurocognitive disorders
may be considered. The disorders can co-occur, and some adults with disorders of intellectual
development are at greater and earlier risk of developing dementia. For example, individuals
with Down syndrome who exhibit a marked decline in adaptive behaviour functioning should be
evaluated for the emergence of dementia. In cases in which the diagnostic requirements for both
a disorder of intellectual development and dementia are met and describe non-redundant aspects
of the clinical presentation, both diagnoses may be assigned.
Boundary with mood disorders
Cognitive concerns and mild measurable cognitive deficits may occur in the context of mood
disorders. These typically improve with appropriate treatment of the corresponding mood
disorder, whereas in dementia neurocognitive impairment is not significantly affected by
treatment of the mood disorder. Standardized assessment or quantified clinical assessment may
be helpful in identifying the presence and objective severity of neurocognitive impairment, which
may not correspond with an individual’s subjective cognitive complaints.
Boundary with factitious disorder and malingering
In factitious disorder and malingering, the neurocognitive symptoms characteristic of dementia
are consciously feigned. Feigned symptoms may be – although they are not necessarily – atypical
in pattern, magnitude or course, or may be medically implausible. Individuals with factitious
disorder feign neurocognitive symptoms in order to seek attention, especially from health-care
providers, and to assume the sick role. Malingering is characterized by intentional feigning of
neurocognitive impairment for obvious external incentives (e.g. disability payments).
Boundary with neurocognitive symptoms in other mental disorders
Neurocognitive symptoms may be a characteristic or associated feature of a wide range of mental
disorders (e.g. schizophrenia and other primary psychotic disorders, post-traumatic stress
disorder, dissociative disorders). If the neurocognitive impairment is better explained by another
mental disorder, an additional diagnosis of dementia should not be assigned.
Specific types of dementia
Dementia due to Alzheimer disease
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying 8A20 Alzheimer disease, based
on quantified clinical assessment or standardized neuropsychological/cognitive testing,
neuroimaging data, genetic testing, medical tests, family history and/or clinical history.
6D80
Neurocognitive disorders | Dementia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Early clinical history is typically characterized by gradual onset, progressive memory
problems and word-finding difficulties, as well as mild functional impairment. The most
common form of Alzheimer disease begins with neuronal impairment in the medial
temporal lobes (the brain regions involved in memory formation).
• As Alzheimer disease progresses and affects other brain regions, neurocognitive
symptoms worsen.
• Atypical forms of Alzheimer disease are also characterized by progressive neurocognitive
and functional impairment, with initial neurocognitive symptoms often corresponding
to the brain region initially affected (e.g. visual processing impairment in posterior
cortical atrophy).
Note: for all forms of dementia due to Alzheimer disease, the diagnosis 8A20 Alzheimer disease
in Chapter 8 on diseases of the nervous system should also be assigned.
Dementia due to Alzheimer disease with early onset
Essential (required) features
• All diagnostic requirements for dementia due to Alzheimer disease are met.
• Neurocognitive, functional and/or behavioural symptoms associated with Alzheimer
disease were present prior to the age of 65 years, as evidenced by neuropsychological
test data, neuroimaging data, genetic testing, medical tests, family history and/or
clinical history.
Dementia due to Alzheimer disease with late onset
Essential (required) features
• All diagnostic requirements for dementia due to Alzheimer disease are met.
• Neurocognitive, functional and/or behavioural symptoms associated with Alzheimer
disease were present at or after the age of 65 years, as evidenced by neuropsychological
test data, neuroimaging data, genetic testing, medical tests, family history and/or
clinical history.
6D80.0
6D80.1
Neurocognitive disorders | Dementia due to Alzheimer disease

213 - 6D81 Dementia due to cerebrovascular disease
6D81 Dementia due to cerebrovascular disease
623
Neurocognitive disorders
Alzheimer disease dementia, mixed type, with cerebrovascular disease
Essential (required) features
• All diagnostic requirements for dementia due to Alzheimer disease are met.
• Neurocognitive, functional and/or behavioural symptoms of dementia appear to be
partially related to co-existing cerebrovascular disease, as demonstrated by neuroimaging,
medical tests and/or clinical history of cerebrovascular disease.
• The clinical course of neurocognitive and functional impairment is progressive, and
typically characterized by combined impairment in so-called cortical cognitive functions
(e.g. memory, language, visuospatial skills) and so-called subcortical cognitive functions
(e.g. attention, processing speed, executive/frontal lobe-related functioning).
Alzheimer disease dementia, mixed type, with other nonvascular etiologies
Essential (required) features
• All diagnostic requirements for dementia due to Alzheimer disease are met.
• Neurocognitive, functional and/or behavioural symptoms of dementia appear to be
partially related to a known comorbid etiology, as demonstrated by neuroimaging data,
genetic testing, medical tests, family history, medical history and/or clinical history.
Dementia due to Alzheimer disease, onset unknown or unspecified
Dementia due to cerebrovascular disease
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying cerebrovascular disease, as
demonstrated by neuroimaging, medical tests and/or clinical history of cerebrovascular
disease.
• The diagnostic requirements for Alzheimer disease dementia, mixed type, with
cerebrovascular disease are not met.
6D80.3
6D80.Z
6D81
Neurocognitive disorders | Dementia due to Alzheimer disease
6D80.2

214 - 6D82 Dementia due to Lewy body disease
6D82 Dementia due to Lewy body disease
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Neurocognitive symptoms often follow cerebrovascular compromise. In stroke, the type
of neurocognitive impairment varies depending on the brain region in which the stroke
occurred. Stroke-related neurocognitive impairment typically begins abruptly after a stroke.
Improvement in initial neurocognitive deficits is typically seen, with recovery reaching a
plateau over time. Residual neurocognitive deficits often remain chronic over time.
• In contrast, in microvascular events, neurocognitive impairment typically affects socalled subcortical neurocognitive functions (e.g. attention, processing speed, executive/
frontal lobe-related functions). If microvascular events are attributed to progressing
chronic conditions (e.g. hypertension, diabetes), as is common, the clinical course of
neurocognitive impairment may be slowly progressive.
Note: an appropriate diagnosis from the Cerebrovascular diseases grouping in Chapter 8 on
diseases of the nervous system should also be assigned.
Dementia due to Lewy body disease
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying Lewy body disease, as demonstrated
by neuropsychological test data, neuroimaging data, genetic testing, medical tests, family
history and/or clinical history.
• Clinical history involves the presence of two or more of the following symptoms:
• recurrent visual hallucinations (typically well-formed)
• episodic confusion
• REM sleep behaviour disorder
• one or more features of parkinsonism (e.g. resting tremor).
Additional clinical features
• Neurocognitive symptoms are progressive, and often involve relatively greater impairment
in visuospatial skills, attention and executive functioning (as opposed to primary memory
impairment, as seen in Alzheimer disease).
• Additional clinical features may include repeated falls, syncope, hallucinations in other
sensory modalities, delusions and autonomic dysfunction (e.g. constipation, urinary
incontinence).
Note: a diagnosis of 8A22 Lewy body disease in Chapter 8 on diseases of the nervous system
should also be assigned.
Neurocognitive disorders | Dementia due to cerebrovascular disease and Lewy body disease
6D82

215 - 6D83 Frontotemporal dementia
6D83 Frontotemporal dementia
625
Neurocognitive disorders
Frontotemporal dementia
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying frontotemporal disease or atrophy,
as demonstrated by neuropsychological test data, neuroimaging data, genetic testing,
medical tests, family history and/or clinical history.
Additional clinical features
• Frontotemporal dementia variants include primary progressive aphasia (logopenic,
semantic and agrammatic subtypes), behavioural frontotemporal dementia and motoric
frontotemporal dementia (corticobasal degeneration, progressive supranuclear palsy and
amyotrophic lateral sclerosis).
• Frontotemporal dementia is progressive, with variants identified based on initial symptoms.
• Frontotemporal dementia, behavioural variant, is characterized by personality changes,
often including apathy and progressively inappropriate social behaviour. Neurocognitive
functioning may be preserved in the early stages, though the progression may later involve
deficits in executive functioning (e.g. planning, problem solving), with comparatively
intact memory skills.
• Frontotemporal dementia, primary progressive aphasia, is characterized by
progressive impairment in language skills, initially in the absence of impairment in other
cognitive skills. Subtypes of primary progressive aphasia are often determined based on
neuropsychological/cognitive testing, clinical presentation and sometimes neuroimaging,
and are characterized by primary deficits in word finding (logopenic subtype), word
meaning (semantic subtype) or word production (agrammatic subtype).
• Frontotemporal dementia, motoric variant, involves progressive impairment in
motor functioning, sometimes in the context of progressive neurocognitive impairment
(typically characterized by impairment in attention, executive functioning and
visuospatial skills, with comparatively intact memory skills). Frontotemporal dementia,
motoric variant, can include progressive supranuclear palsy (e.g. poor balance, frequent
falls, visual impairment from gaze palsy), corticobasal degeneration (e.g. limb apraxia,
tripping, rigidity, dystonia) and amyotrophic lateral sclerosis (e.g. muscle weakness,
muscle atrophy, fasciculations, spasticity).
Note: a diagnosis of 8A23 Frontotemporal lobar degeneration in Chapter 8 on diseases of the
nervous system should also be assigned.
6D83
Neurocognitive disorders | Frontotemporal dementia

216 - 6D84 Dementia due to psychoactive substances,
6D84 Dementia due to psychoactive substances, including medications

217 - 6D85 Dementia due to diseases classified else
6D85 Dementia due to diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Dementia due to psychoactive substances, including medications
Essential (required) features
• All diagnostic requirements for dementia are met.
• There is evidence from history, physical examination or laboratory findings that dementia
is caused by the direct physiological consequences of use of a substance or medication that
persists beyond the usual duration of substance intoxication or withdrawal.
• This judgement depends on establishing the following.
• The substance or medication and the amount and duration of its use is known to be
capable of producing dementia.
• The course of the dementia (e.g. onset, trajectory of symptoms, response to treatment)
is consistent with that caused by the substance or medication.
Note: specific substances are known to be capable of producing dementia. If the specific substance
inducing the dementia has been identified, the corresponding diagnostic category should be
assigned:
6D84.0 Dementia due to use of alcohol
6D84.1 Dementia due to use of sedatives, hypnotic or anxiolytics
6D84.2 Dementia due to use of volatile inhalants
6D84.Y Dementia due to other specified psychoactive substance.
A diagnosis corresponding to the pattern of use of the relevant psychoactive substance (e.g.
harmful pattern of psychoactive substance use, substance dependence) may also be assigned.
Dementia due to diseases classified elsewhere
The following categories for dementia associated with other diseases or conditions known to
cause dementia are available:
6D85.0
Dementia due to Parkinson disease
6D85.1
Dementia due to Huntington disease
6D85.2
Dementia due to exposure to heavy metals and other toxins
6D85.3
Dementia due to HIV
6D85.4
Dementia due to multiple sclerosis
6D85.5
Dementia due to prion disease
6D85.6
Dementia due to normal-pressure hydrocephalus
6D85.7
Dementia due to injury to the head
6D85.8
Dementia due to Pellagra
6D85.9
Dementia due to Down syndrome
6D85.Y
Dementia due to other specified disease classified elsewhere.
6D85
Neurocognitive disorders | Dementia due to psychoactive substances, including medications
6D84
627
Neurocognitive disorders
Dementia due to Parkinson disease
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying Parkinson disease, as demonstrated
by neuropsychological test data, neuroimaging data, medical tests, family history and/or
clinical history.
Additional clinical features
• Dementia due to Parkinson disease develops among individuals with idiopathic Parkinson
disease, and is often characterized by impairment in attention, memory, executive and
visuospatial functions.
• Behavioural and psychiatric symptoms such as changes in affect, apathy and hallucinations
may also be present.
• Onset is insidious and typically occurs 1 year or more after the development of Parkinsonian
motor symptoms. The course of dementia often follows that of underlying Parkinson
disease (e.g. if Parkinson disease gradually worsens, dementia may gradually worsen).
Note: a diagnosis of 8A00.0 Parkinson disease in Chapter 8 on diseases of the nervous system
should also be assigned.
Dementia due to Huntington disease
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying Huntington disease, as demonstrated
by neuropsychological test data, neuroimaging data, genetic testing, medical tests, family
history and/or clinical history.
Additional clinical features
• Dementia due to Huntington disease occurs as part of a widespread degeneration of
the brain due to a trinucleotide repeat expansion in the HTT gene, which is transmitted
through autosomal dominance.
6D85.0
6D85.1
Neurocognitive disorders | Dementia due to diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Onset of symptoms is insidious, typically in the third and fourth decade of life, with
gradual and slow progression.
• Initial symptoms typically include impairments in executive functions, with relative sparing
of memory, prior to the onset of motor deficits (bradykinesia and chorea) characteristic of
Huntington disease.
Note: a diagnosis of 8A01.10 Huntington disease in Chapter 8 on diseases of the nervous system
should also be assigned.
Dementia due to exposure to heavy metals and other toxins
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to toxic exposure to specific heavy metals, such
as aluminium from dialysis water, lead, mercury or manganese, as demonstrated by
neuropsychological test data, neuroimaging data, medical tests and/or clinical history.
Additional clinical features
• The characteristic neurocognitive impairments in dementia due to exposure to heavy
metals and other toxins depend on the specific heavy metal or toxin that the individual has
been exposed to, but can affect any cognitive domain.
• Onset of symptoms is related to exposure, and progression can be rapid especially with
acute exposure.
• In some cases, symptoms are reversible when exposure is identified and ceases.
Note: an appropriate diagnosis from the NE61 Harmful effects of or exposure to noxious
substances, chiefly nonmedicinal as to source, not elsewhere classified, grouping in Chapter 22
on injury, poisoning or certain other consequences of external causes should also be assigned.
Dementia due to HIV
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying HIV disease, as demonstrated by
neuropsychological test data, neuroimaging data, medical tests and/or clinical history.
6D85.2
6D85.3
Neurocognitive disorders | Dementia due to diseases classified elsewhere
629
Neurocognitive disorders
Additional clinical features
• Dementia due to HIV may develop during the course of confirmed HIV disease, in the
absence of a concurrent illness or condition other than HIV infection that could explain
the clinical features.
• Although a variety of patterns of neurocognitive deficits are possible, depending on where
the HIV pathogenic processes have occurred, typically deficits follow a subcortical pattern
with impairments in executive function, processing speed, attention and learning new
information.
• The course of dementia due to HIV, varies and may involve gradual decline in functioning,
improvement or resolution of symptoms, or fluctuation in symptoms over time.
• Rapid decline in neurocognitive functioning is rare, with the advent of antiretroviral
medications.
Note: an appropriate diagnosis from the Human immunodeficiency virus disease grouping in
Chapter 1 on certain infectious or parasitic diseases should also be assigned.
Dementia due to multiple sclerosis
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to the cerebral effects of underlying multiple
sclerosis – a demyelinating disease – as demonstrated by neuropsychological test data,
neuroimaging data, medical tests and/or clinical history. Cognitive symptoms are not
primarily due to associated physiological or functional effects of the underlying disease
(e.g. fatigue, motoric limitations).
Additional clinical features
• Onset of symptoms is often insidious, but progression may occur in a stepwise fashion, in
accordance with the underlying disease course.
• Neurocognitive impairments vary according to the location of demyelination, but
typically include deficits in processing speed, memory, attention and aspects of executive
functioning.
Note: a diagnosis of 8A40 Multiple sclerosis in Chapter 8 on diseases of the nervous system should
also be assigned.
6D85.4
Neurocognitive disorders | Dementia due to diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Dementia due to prion disease
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying human prion disease, as
demonstrated by neuropsychological test data, neuroimaging data, genetic testing, medical
tests and/or clinical history.
Additional clinical features
• Dementia due to prion disease is caused by a group of spongiform encephalopathies
resulting from abnormal prion protein accumulation in the brain. These can be sporadic,
genetic (caused by mutations in the prion protein gene) or transmissible (acquired from
an infected individual).
• Onset is insidious, and progression of symptoms and impairment is rapid, often
characterized by neurocognitive deficits, ataxia and motor symptoms (e.g. myoclonus,
chorea or dystonia).
• Diagnosis is typically made on the basis of clinical presentation, brain imaging studies,
presence of characteristic proteins in spinal fluid, EEG and/or genetic testing.
Note: an appropriate diagnosis from the Human prion diseases grouping in Chapter 8 on diseases
of the nervous system should also be assigned.
Dementia due to normal-pressure hydrocephalus
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to underlying normal-pressure hydrocephalus,
as demonstrated by neuropsychological test data, neuroimaging data, medical tests and/
or clinical history.
6D85.5
6D85.6
Neurocognitive disorders | Dementia due to diseases classified elsewhere
631
Neurocognitive disorders
Additional clinical features
• Dementia due to normal-pressure hydrocephalus results from excess accumulation of
cerebrospinal fluid in the brain as a result of idiopathic, non-obstructive causes, but can
also be secondary to haemorrhage, infection or inflammation.
• Progression is gradual but intervention (e.g. shunt) may result in improvement of
symptoms, especially if administered early in the course of the condition.
• Typically, neurocognitive impairments include reduced processing speed and deficits in
executive functioning and attention. These symptoms are also typically accompanied by
gait abnormalities and urinary incontinence.
• Brain imaging to reveal ventricular volume and characterize brain displacement is often
necessary to confirm the diagnosis.
Note: a diagnosis of 8D64.04 Normal-pressure hydrocephalus in Chapter 8 on diseases of the
nervous system should also be assigned.
Dementia due to injury to the head
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to an injury to the head, as demonstrated by
neuropsychological test data, neuroimaging data, medical tests and/or clinical history.
Additional clinical features
• Dementia due to injury to the head is caused by damage inflicted on the tissues of the brain
as the direct or indirect result of an external force.
• Trauma to the brain is known to have resulted in loss of consciousness, amnesia,
disorientation and confusion, and/or neurological signs.
• The symptoms characteristic of dementia due to injury to the head arise immediately
following the trauma or after the individual gains consciousness, and must include
persistent cognitive impairments following any recovery of initial cognitive impairment
that may be seen in the immediate post-injury period.
• Neurocognitive deficits vary depending on the specific brain areas affected and the severity
of the injury, but can include impairments in attention, memory, executive functioning,
personality, processing speed, social cognition and language abilities.
Note: a diagnosis of NA07 Intracranial injury or one of its subcategories in Chapter 22 on injury,
poisoning or certain other consequences of external causes should also be assigned.
6D85.7
Neurocognitive disorders | Dementia due to diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Dementia due to pellagra
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to pellagra, as demonstrated by neuropsychological
test data, medical tests and/or clinical history.
Additional clinical features
• Dementia due to pellagra is caused by persistent lack of vitamin B3 (niacin) or tryptophan
either in the diet or due to poor absorption in the gastrointestinal tract due to disease (e.g.
Crohn disease) or due to the effects of some medications (e.g. isoniazid).
• Core signs of pellagra include dermatological changes (sensitivity to sunlight, lesions,
alopecia and oedema) and diarrhoea.
• With prolonged nutritional deficiency, neurocognitive symptoms that include aggression,
motor disturbances (ataxia and restlessness), confusion and weakness may be observed.
• Treatment with nutritional supplementation (e.g. niacin) typically results in reversal of
symptoms.
Note: a diagnosis of 5B5C.0 Pellagra in Chapter 5 on endocrine, nutritional or metabolic diseases
should also be assigned.
Dementia due to Down syndrome
Essential (required) features
• All diagnostic requirements for dementia are met.
• Dementia is presumed to be attributable to Down syndrome, as demonstrated by
neuropsychological test data, genetic testing, medical tests and/or clinical history.
Additional clinical features
• Dementia due to Down syndrome is caused by abnormal increased production and
accumulation of amyloid precursor protein (APP), leading to formation of beta-amyloid
6D85.8
6D85.9
Neurocognitive disorders | Dementia due to diseases classified elsewhere

218 - 6D8Y Dementia, other specified cause
6D8Y Dementia, other specified cause
633
Neurocognitive disorders
plaques and tau tangles. APP gene expression is increased due to its location on chromosome
21, which is abnormally triplicated in Down syndrome. Dementia due to Down syndrome
may affect 50% or more of individuals with Down syndrome.
• Neurocognitive deficits and neuropathological features are similar to those observed in
Alzheimer disease.
• Onset is typically after the fourth decade of life, and is often accompanied by a gradual
decline in functioning.
Note: a diagnosis of LD40.0 Complete trisomy 21 (Down syndrome) in Chapter 20 on
developmental abnormalities should also be assigned.
Dementia due to other specified disease classified elsewhere
Essential (required) features
• All diagnostic requirements for dementia are met.
• The dementia is presumed to be attributable to an underlying disease of the nervous
system, trauma, infection, tumour or other disease process affecting specific areas of the
brain that is listed in ICD-11 but is not adequately captured by any of the other available
dementia categories, as demonstrated by neuropsychological test data, neuroimaging data,
genetic testing, medical tests, family history and/or clinical history.
• This judgement depends on establishing the following.
• The specified cause is known to be capable of producing the symptoms.
• The course of the impairment (e.g. onset, trajectory of symptoms, response to treatment)
is consistent with that known to be associated with the specified cause.
Note: the ICD-11 diagnosis corresponding to the presumed etiology should also be assigned.
Dementia, other specified cause
Essential (required) features
• All diagnostic requirements for dementia are met.
• The dementia is presumed to be attributable to an identified and specified underlying cause
affecting specific areas of the brain that is not listed elsewhere in ICD-11 (and is therefore
not classifiable using any of the other available dementia categories, including dementia
due to other specified disease classified elsewhere), as demonstrated by neuropsychological
test data, neuroimaging data, genetic testing, medical tests, family history and/or clinical
history.
• This judgement depends on establishing the following.
• The specified cause is known to be capable of producing the symptoms.
• The course of the impairment (e.g. onset, trajectory of symptoms, response to treatment)
is consistent with that known to be associated with the specified cause.
6D85.Y
6D8Y
Neurocognitive disorders | Dementia due to diseases classified elsewhere

219 - 6D8Z Dementia, unknown or unspecified cause
6D8Z Dementia, unknown or unspecified cause

22 - 6A2Y Other specified primary psychotic disord
6A2Y Other specified primary psychotic disorder

220 - Specifier for dementia severity
Specifier for dementia severity
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The symptoms are not better accounted for by disturbance of consciousness or altered
mental status (e.g. due to seizure, traumatic brain injury, stroke or the effects of medication),
delirium, substance intoxication, substance withdrawal or another mental disorder (e.g.
schizophrenia or another primary psychotic disorder, a mood disorder, post-traumatic
stress disorder, a dissociative disorder).
• The symptoms result in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning. In mild cases, if functioning is
maintained, it is only through significant additional effort (e.g. compensatory strategies).
Dementia, unknown or unspecified cause
Specifier for dementia severity
Severity of dementia can be rated as mild (XS5W), moderate (XS0T) or severe (XS25), according
to the degree of neurocognitive and functional impairment, and the capacity for independence in
activities of daily living. Severity is rated based on objective clinical examination and information
provided by an informant who has sufficient contact with the patient, such as a family member
or caregiver.
To indicate severity, the code for the appropriate severity level is appended to the diagnostic code
for the type of dementia using an ampersand (&). For example, “6D82&XS0T” is the code for
dementia due to Lewy body disease, moderate.
Mild dementia
Individuals with mild dementia may be able to live independently, but some supervision and/
or support is often required. However, individuals with mild dementia can still take part in
community or social activities without help, and may appear unimpaired to those who do not
know them well. Judgement and problem solving are typically impaired, but social judgement
may be preserved, depending on the etiology. The individual may have difficulty making complex
decisions, making plans and/or handling finances (e.g. calculating change, paying bills).
Moderate dementia
Individuals with moderate dementia require support to function outside the home, and only
simple household tasks are maintained. Individuals with moderate dementia have difficulties
with basic activities of daily living, such as dressing and personal hygiene. Moderate dementia
is often characterized by significant memory loss. Judgement and problem solving are typically
significantly impaired, and social judgement is often compromised. The individual has increasing
difficulty making complex or important decisions, and is often easily confused. The individual
may have difficulty communicating with individuals outside the home without caregiver
assistance. Socializing is increasingly difficult, as the individual may behave inappropriately (e.g.
Neurocognitive disorders | Dementia, unknown or unspecified cause
6D8Z
XS5W
XS0T

221 - Specifiers for behavioural or psychological d
Specifiers for behavioural or psychological disturbances in dementia
635
Neurocognitive disorders
in disinhibited or aggressive ways), with associated behaviour changes (e.g. calling out, clinging,
wandering, disturbed sleep, hallucinations). The difficulties are often obvious to most individuals
who have contact with the individual.
Severe dementia
Severe dementia is typically characterized by severe memory impairment, but this varies
according to the etiology. There is often total disorientation for time and place. The individual is
often completely unable to make judgements or solve problems. Individuals may have difficulty
understanding what is happening around them. Individuals are fully dependent on others for
basic personal care in activities such as for bathing, toileting and feeding. Urinary and faecal
incontinence may emerge at this stage.
Specifiers for behavioural or psychological disturbances in dementia
Behavioural and psychological disturbances are common in dementia. Examples of such
symptoms include apathy, mood disturbances, hallucinations, delusions, irritability, agitation,
aggression and sleep changes. Typically, these symptoms are more frequent and impairing
in moderate and severe forms of dementia, although this varies by etiology. Behavioural and
psychological disturbances may be present in early stages of dementia (such as in frontotemporal
dementia), and may be more prominent than neurocognitive symptoms.
Specifiers for behavioural or psychological disturbances in dementia should be used when, in
addition to the neurocognitive and other disturbances characteristic of dementia, the current
clinical picture includes behavioural or psychological symptoms that are severe enough to
represent a focus of clinical intervention. As many of the following specifiers may be added to the
dementia diagnosis as necessary to describe the relevant aspects of the current clinical picture.
Psychotic symptoms in dementia
The current clinical picture includes clinically significant delusions or hallucinations.
Mood symptoms in dementia
The current clinical picture includes clinically significant mood symptoms such as depressed
mood, elevated mood or irritable mood.
Anxiety symptoms in dementia
The current clinical picture includes clinically significant symptoms of anxiety or worry.
6D86.0
6D86.1
Neurocognitive disorders | Dementia, unknown or unspecified cause
XS25
6D86.2
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Apathy in dementia
The current clinical picture includes clinically significant indifference or lack of interest.
Agitation or aggression in dementia
The current clinical picture includes clinically significant excessive psychomotor activity
accompanied by increased tension, and/or hostile or violent behaviour.
Disinhibition in dementia
The current clinical picture includes clinically significant lack of restraint manifested in
disregard for social conventions, impulsivity and poor risk assessment.
Wandering in dementia
The current clinical picture includes clinically significant wandering that puts the person at
risk of harm.
Other specified behavioural or psychological disturbance in dementia
The current clinical picture includes other behavioural or psychological symptoms as a part
of the dementia that are severe enough to represent a focus of clinical intervention.
Behavioural or psychological disturbance in dementia, unspecified
6D86.3
6D86.4
6D86.5
6D86.6
6D86.Y
6D86.Z
Neurocognitive disorders | Dementia, unknown or unspecified cause

222 - 6E0Y Other specified neurocognitive disorder
6E0Y Other specified neurocognitive disorder

223 - 6E0Z Neurocognitive disorder, unspecified
6E0Z Neurocognitive disorder, unspecified
637
Neurocognitive disorders
Other specified neurocognitive disorder
Essential (required) features
The presence of impairment in one more or cognitive domains (e.g. attention, executive function,
language, memory, perceptual-motor abilities, social cognition) relative to the level expected
given the individual’s age and general premorbid level of neurocognitive functioning, and that
does not meet the diagnostic requirements for any other neurocognitive disorder, is required
for diagnosis.
• The neurocognitive impairment represents a decline from the individual’s previous level
of functioning.
• Evidence of neurocognitive impairment is based on information obtained from the
individual, an informant or clinical observation, and is accompanied by objective evidence
of impairment by quantified clinical assessment or standardized neuropsychological/
cognitive testing.
• Neurocognitive impairment is not attributable to normal ageing.
• Neurocognitive impairment may be attributable to an underlying acquired disease of the
nervous system, a trauma, an infection or other disease process affecting the brain, use
of specific substances or medications, nutritional deficiency or exposure to toxins, or the
etiology may be undetermined.
• Neurocognitive impairment is not better accounted for by disturbance of consciousness
or altered mental status (e.g. due to seizure, traumatic brain injury, stroke or the effects of
medication), a neurodevelopmental disorder, substance intoxication, substance withdrawal
or another mental disorder (e.g. schizophrenia or another primary psychotic disorder, a
mood disorder, post-traumatic stress disorder, a dissociative disorder).
Note: when the neurocognitive impairment is due to a disease, condition or injury classified
elsewhere (including disorders due to substance use), the diagnostic code corresponding to that
disease, condition or injury should also be assigned. In the presence of an identified etiological
medical condition, if the neurocognitive symptoms are of short duration (e.g. less than 1 month),
and it is expected that with treatment of the causal medical condition the neurocognitive
symptoms will remit, a diagnosis of secondary neurocognitive syndrome may be assigned rather
than other specified neurocognitive disorder.
Neurocognitive disorder, unspecified
Neurocognitive disorders | Other specified neurocognitive disorder
6E0Y
6E0Z
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

224 - Mental and behavioural disorders associated w
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
639
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
Mental and behavioural disorders
associated with pregnancy,
childbirth or the puerperium
Mental and behavioural disorders associated with
pregnancy, childbirth or the puerperium, without
psychotic symptoms
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium are
syndromes associated with pregnancy or the puerperium (commencing within about 6 weeks
after delivery) that involve significant mental and behavioural features. These diagnoses may
be assigned regardless of whether biological factors related to pregnancy, childbirth or the
puerperium are known to be etiologically related to the syndrome. If the symptoms meet the
diagnostic requirements for another mental disorder, that diagnosis should also be assigned.
These diagnoses may be assigned even if the syndrome represents a recurrence or exacerbation
of a pre-existing disorder.
Mental and behavioural disorders associated with
pregnancy, childbirth or the puerperium, with
psychotic symptoms
Mental and behavioural disorders associated with
pregnancy, childbirth or the puerperium, unspecified.
6E20
6E21
6E2Z
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium include the following:

225 - 6E20 Mental and behavioural disorders associa
6E20 Mental and behavioural disorders associated with pregnancy, childbirth or the ...
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, without psychotic symptoms
Essential (required) features
• Onset of a syndrome involving significant mental and behavioural features occurring
during pregnancy or the puerperium (i.e. up to about 6 weeks following delivery) is
required for diagnosis.
• The syndrome does not include delusions, hallucinations or other psychotic symptoms.
• The symptoms are not a manifestation of another medical condition (e.g. a brain tumour),
and are not due to the effects of a substance or medication on the central nervous system
(e.g. benzodiazepines), including withdrawal effects (e.g. from stimulants).
• The disturbance results in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning. If functioning is maintained, it is
only through significant additional effort.
Note: if the symptoms meet the diagnostic requirements for a specific mental disorder (e.g. a
mood disorder, an anxiety or fear-related disorder, obsessive-compulsive disorder, adjustment
disorder), that diagnosis should also be assigned. If the symptoms do not meet the diagnostic
requirements for a specific mental disorder, the presentation can be described using codes from
the section on mental or behavioural symptoms, signs or clinical findings (p. 677).
Additional clinical features
• This diagnosis may be assigned regardless of whether biological factors related pregnancy,
childbirth or the puerperium are known to be etiologically related to the syndrome.
• Common presentations of mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, without psychotic symptoms, include the following.
Depressive symptoms
These may include depressed mood, excessive crying; difficulty bonding with the baby;
withdrawing from family and friends; loss of appetite or eating much more than usual; inability to
sleep (insomnia) or sleeping too much; overwhelming fatigue or loss of energy; reduced interest
and pleasure in usually enjoyable activities, intense irritability and anger; fears of not being a good
mother, feelings of worthlessness, shame, guilt or inadequacy; diminished ability to think clearly,
concentrate or make decisions; thoughts of harming oneself or the baby.
Anxiety symptoms
These may include excessive worry, general apprehensiveness not restricted to any particular
environmental stimulus, phobic responses (e.g. related to dirt or germs) and panic attacks.
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
6E20
641
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
Obsessions and compulsions
Obsessions are repetitive and persistent thoughts, images or impulses/urges that are experienced
as intrusive and unwanted, and are commonly associated with anxiety. Compulsions are repetitive
behaviours or rituals, including repetitive mental acts, that the individual feels driven to perform
in response to an obsession. Obsessions and compulsions typically focus on the newborn or
unborn infant (e.g. obsessions about the baby getting hurt, contaminated or lost; compulsive
rituals involving checking, mental rituals and seeking reassurance). Unwanted sexual obsessions
may also be present. There may also be excessive avoidance, such as avoiding bathing or holding
the baby, in response to the obsessions.
Boundary with normality (threshold)
• This diagnosis should not be used to describe mild and transient depressive symptoms that
do not meet the diagnostic requirements for a depressive episode, which may occur soon
after delivery (so-called “postpartum blues” or “baby blues”).
• Postpartum depression may be mistaken for baby blues at first, but the signs and symptoms
are more intense, last longer, and interfere with functioning, including the ability to care
for the baby. If the diagnostic requirements are met for a depressive episode, a diagnosis of
single episode depressive disorder or recurrent depressive disorder should also be assigned.
• Worries and fears about the baby during pregnancy and after childbirth and some degree
of intrusive thoughts about possible harms are common, and should not be diagnosed
as mental and behavioural disorders associated with pregnancy, childbirth or the
puerperium unless they are persistent, associated with substantial distress, and interfere
with functioning, including the ability to care for the baby.
Boundaries with other disorders and conditions (differential diagnosis)
• This diagnosis may be assigned even if the syndrome represents a recurrence or exacerbation
of a pre-existing disorder (e.g. a mood disorder).
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium

226 - 6E21 Mental and behavioural disorders associa
6E21 Mental and behavioural disorders associated ...
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, with psychotic symptoms
Essential (required) features
• Onset of a syndrome involving significant mental and behavioural features occurring
during pregnancy or the puerperium (i.e. up to about 6 weeks following delivery) is
required for diagnosis.
• The syndrome includes psychotic symptoms (i.e. delusions, hallucinations or other
psychotic symptoms). Depressive and/or manic mood symptoms are also typically present.
• The symptoms are not a manifestation of another medical condition (e.g. a brain tumour),
and are not due to the effects of a substance or medication on the central nervous system
(e.g. benzodiazepines), including withdrawal effects (e.g. from stimulants).
• The disturbance results in significant impairment in personal, family, social, educational,
occupational or other important areas of functioning. If functioning is maintained, it is
only through significant additional effort.
Note: this diagnosis may be assigned regardless of whether biological factors related to pregnancy,
childbirth or the puerperium are known to be etiologically related to the syndrome. If the
symptoms meet the diagnostic requirements for a specific mental disorder (e.g. a mood disorder,
schizophrenia or another primary psychotic disorder), that diagnosis should also be assigned.
If the symptoms do not meet the diagnostic requirements for a specific mental disorder, the
presentation can be described using codes from the section on mental or behavioural symptoms,
signs or clinical findings (p. 677).
Additional clinical features
• Psychotic symptoms in mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium most commonly occur in the context of a depressive, manic
or mixed mood episode, in which case a diagnosis of single episode depressive disorder,
recurrent depressive disorder or bipolar type I disorder should also be assigned.
• Additional symptoms may include confusion and disorientation, sleep disturbance,
excessive energy and agitation, obsessions and compulsions, paranoid ideation and
attempts to harm oneself or the baby.
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
6E21

227 - 6E2Z Mental and behavioural disorders associa
6E2Z Mental and behavioural disorders associated with ...
643
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
Boundary with normality (threshold)
• Psychotic-like symptoms or unusual subjective experiences may occur in the general
population, but these are usually fleeting in nature and do not interfere with functioning,
and the person is typically aware that they are illusions. Such phenomena should not be
diagnosed as mental and behavioural disorders associated with pregnancy, childbirth or
the puerperium.
Boundaries with other disorders and conditions (differential diagnosis)
• This diagnosis may be assigned even if the syndrome represents a recurrence or
exacerbation of a pre-existing disorder (e.g. a mood disorder, schizophrenia or another
primary psychotic disorder).
Mental and behavioural disorders associated with pregnancy,
childbirth or the puerperium, unspecified
6E2Z
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

228 - Psychological or behavioural factors affectin
Psychological or behavioural factors affecting disorders and diseases classified elsewhere

229 - 6E40 Psychological or behavioural factors aff
6E40 Psychological or behavioural factors affecting disorders and diseases classified elsewhere
645
Psychological or behavioural factors affecting disorders and diseases classified elsewhere
Psychological or behavioural
factors affecting disorders and
diseases classified elsewhere
Psychological or behavioural factors affecting disorders and diseases
classified elsewhere
Essential (required) features
• Psychological or behavioural factors are present that adversely affect the manifestation,
treatment or course of a disorder or disease classified in another ICD-11 chapter in one or
more of the following ways.
• The factors interfere with the treatment of the disorder or disease by affecting treatment
adherence or care seeking (e.g. avoidance of needed medical care in an individual with
anxiety, non-adherence to a complex treatment regimen in an individual with personality
disorder).
• The factors constitute an additional health risk to the person with the disorder or disease
classified elsewhere (e.g. binge eating in a person with diabetes).
• The factors influence the underlying pathophysiology to precipitate or exacerbate
symptoms, or otherwise necessitate medical attention (e.g. stress response causing chest
pain in an individual with coronary heart disease or anxiety causing bronchospasm in
an individual with asthma).
• The factors increase the risk of suffering, disability or death.
• The factors represent a focus of clinical attention.
6E40
Psychological or behavioural factors affecting disorders and diseases classified elsewhere

23 - 6A2Z Schizophrenia or other specified primary
6A2Z Schizophrenia or other specified primary psychotic disorder, unspecified
189
Schizophrenia and other primary psychotic disorders
Boundary with dementia
Delusions – especially persecutory delusions – may occur as a symptom of dementia, particularly
among older adults. Such delusions are differentiated from delusional disorder in that they have their
onset during the dementia and are, by definition, due to another medical condition or prolonged
substance use. In contrast, the delusions in delusional disorder must have had their onset prior
to the onset of dementia. In cases where dementia has developed in someone with an established
diagnosis of delusional disorder, both diagnoses may be assigned.
Boundary with delirium
Delusions may also be a prominent feature of delirium. In delirium, however, the individual also
has a fluctuating clouding of consciousness (i.e. reduced ability to direct, focus, sustain, and shift
attention) and awareness (i.e. reduced orientation to the environment). In contrast, in delusional
disorder, there is no disturbance of attention or consciousness.
Other specified primary psychotic disorder
Essential (required) features
• The presentation is characterized by psychotic symptoms that share primary clinical
features with disorders in the schizophrenia and other primary psychotic disorders
grouping (e.g. delusions, hallucinations, formal thought disorder, grossly disorganized or
catatonic behaviour).
• The symptoms do not fulfil the diagnostic requirements (e.g. in severity, frequency
or duration) for any other disorder in the schizophrenia and other primary psychotic
disorders grouping.
• The symptoms are not better accounted for by another mental, behavioural or
neurodevelopmental disorder (e.g. a mood disorder, a disorder specifically associated with
stress, a dissociative disorder).
• The symptoms or behaviours are not developmentally appropriate or culturally sanctioned.
• The symptoms or behaviours are not a manifestation of another medical condition (e.g. a
brain tumour), and are not due to the effects of a substance or medication on the central
nervous system (e.g. corticosteroids), including withdrawal effects (e.g. from alcohol).
• The symptoms result in significant distress or significant impairment in personal, family,
social, educational, occupational or other important areas of functioning.
Schizophrenia or other primary psychotic disorder, unspecified
6A2Y
6A2Z
Schizophrenia and other primary psychotic disorders | Other specified or unspecified psychotic disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

230 - 6E40.0 Mental disorder affecting disorders an
6E40.0 Mental disorder affecting disorders and diseases classified elsewhere

231 - 6E40.1 Psychological symptoms affecting disor
6E40.1 Psychological symptoms affecting disorders and diseases classified elsewhere

232 - 6E40.2 Personality traits or coping style aff
6E40.2 Personality traits or coping style affecting disorders and diseases classified elsewhere

233 - 6E40.3 Maladaptive health behaviours affectin
6E40.3 Maladaptive health behaviours affecting disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Categories describing specific types of factors
• The following categories may be used to describe the specific types of psychological or
behavioural factors that adversely affect the manifestation, treatment or course of a disorder
or disease classified in another ICD-11 chapter. Multiple categories may be assigned as
necessary to describe the clinical presentation.
Mental disorder affecting disorders and diseases classified elsewhere
• The presence of a mental, behavioural or neurodevelopmental disorder that adversely
affects the manifestation, treatment or course of a disorder or disease classified in another
chapter is required for diagnosis (e.g. a woman with bulimia nervosa and type 1 diabetes
mellitus who skips insulin doses as a way to avoid weight gain that would otherwise be
caused by her binge eating).
Psychological symptoms affecting disorders and diseases classified
elsewhere
• The presence of psychological symptoms that do not meet the diagnostic requirements
for a mental, behavioural or neurodevelopmental disorder that adversely affect the
manifestation, treatment or course of a disorder or disease classified in another chapter is
required for diagnosis (e.g. depressive symptoms interfering with rehabilitation following
surgery).
Personality traits or coping style affecting disorders and diseases classified
elsewhere
• The presence of personality traits or coping styles that do not meet the diagnostic
requirements for a mental, behavioural or neurodevelopmental disorder that adversely
affect the manifestation, treatment or course of a disorder or disease classified in another
chapter is required for diagnosis (e.g. pathological denial of the need for surgery in a
patient with cancer; hostile, pressured behaviour contributing to heart disease).
Maladaptive health behaviours affecting disorders and diseases classified
elsewhere
• The presence of maladaptive health behaviours that adversely affect the manifestation,
treatment or course of a disorder or disease classified in another chapter is required for
diagnosis (e.g. overeating, lack of exercise).
6E40.0
6E40.1
6E40.2
6E40.3
Psychological or behavioural factors affecting disorders and diseases classified elsewhere

234 - 6E40.4 Stress related physiological response
6E40.4 Stress-related physiological response affecting disorders and diseases classified elsewhere

235 - 6E40.Y Other specified psychological or behav
6E40.Y Other specified psychological or behavioural factor affecting disorders...

236 - 6E40.Z Psychological or behavioural factor af
6E40.Z Psychological or behavioural factor affecting disorders and diseases classified...
647
Psychological or behavioural factors affecting disorders and diseases classified elsewhere
Stress-related physiological response affecting disorders and diseases
classified elsewhere
• The presence of stress-related physiological responses that adversely affect the
manifestation, treatment or course of a disorder or disease classified in another chapter is
required for diagnosis (e.g. stress-related exacerbation of ulcer, hypertension, arrhythmia
or tension headache).
Other specified psychological or behavioural factor affecting disorders and diseases
classified elsewhere
• The presence of other psychological or behavioural factors that adversely affect the
manifestation, treatment or course of a disorder or disease classified in another chapter is
required for diagnosis (e.g. interpersonal, cultural, or religious factors).
Psychological or behavioural factor affecting disorders and diseases classified
elsewhere, unspecified
Additional clinical features
• The adverse effects can range from acute, with immediate medical consequences
(e.g. anxiety precipitating a cardiac arrhythmia), to chronic, occurring over a long period
of time (e.g. chronic occupational stress aggravating diabetes). The adverse effects may
be time-limited, episodic, or chronic and persistent. The disorders or diseases potentially
affected by psychological or behavioural factors include those with clear pathophysiology
(e.g. hypertension, HIV infection, coronary disease), functional syndromes (e.g. chronic
fatigue syndrome, irritable bowel syndrome, fibromyalgia) and idiopathic symptoms
(e.g. dizziness, tinnitus).
Developmental presentations
• Psychological or behavioural factors affecting disorders and diseases classified elsewhere
can occur across the lifespan. Particularly with young children, collateral history from
parents or school personnel can assist in diagnosis. Some psychological or behavioural
factors are more prevalent at particular stages of life (e.g. body-image concerns
in adolescents).
6E40.Y
6E40.Z
Psychological or behavioural factors affecting disorders and diseases classified elsewhere
6E40.4
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Culture-related features
• Differences between cultures may influence psychological or behavioural factors and their
effects on other conditions, such as linguistic and verbal communication, explanatory
models of illness, health-care practices and delivery, provider-patient relationships, family
and gender roles, and attitudes towards pain and death.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with adjustment disorder
Stress associated with having a medical condition can cause psychological or behavioural
symptoms that may meet the diagnostic requirements for adjustment disorder – specifically
preoccupation with the stressor or its consequences, including excessive worry, recurrent and
distressing thoughts about the stressor, or constant rumination about its implications that
results in significant impairment in personal, family, social, educational, occupational or other
important areas of functioning. In psychological or behavioural factors affecting disorders and
diseases classified elsewhere, the causality is in the opposite direction; that is, psychological or
behavioural factors adversely affect an existing medical condition. For example, an individual
who, in the weeks following a heart attack, develops severe anxiety whenever they leave the
house because they are afraid of experiencing cardiac symptoms when no help is available
might be appropriately diagnosed as having adjustment disorder. In contrast, an individual with
atherosclerotic heart disease who develops chest pain whenever they become anxious would be
diagnosed with psychological or behavioural factors affecting disorders and diseases classified
elsewhere. In clinical practice, however, psychological factors and a medical condition are often
mutually exacerbating, in which case both diagnoses may be assigned if it is clinically useful to
do so.
Boundary with hypochondriasis (health anxiety disorder)
Hypochondriasis is characterized by persistent preoccupation with or fear about the possibility of
having one or more serious, progressive or life-threatening diseases. The focus of clinical care is
the individual’s worry about having a disease; in most cases, no serious medical disease is present.
In psychological or behavioural factors affecting disorders and diseases classified elsewhere,
anxiety may be a relevant psychological factor affecting a medical condition, but the clinical
concern is the adverse effects of the anxiety on the manifestations, course or treatment of the
medical condition.
Boundary with bodily distress disorder occurring in an individual with an established
medical condition
Bodily distress disorder occurring in an individual with an established medical condition is
characterized by a combination of distressing bodily symptoms and a degree of attention related
to the symptoms that is clearly excessive in relation to the nature and severity of the medical
condition. In contrast, in psychological or behavioural factors affecting disorders and diseases
classified elsewhere, the psychological or behavioural factors themselves adversely affect the
Psychological or behavioural factors affecting disorders and diseases classified elsewhere
649
Psychological or behavioural factors affecting disorders and diseases classified elsewhere
manifestations, course or treatment of the medical condition. In cases where the excessive
attention paid to the bodily symptoms does adversely affect the medical condition (e.g. repeated
contact with medical professionals that result in medically unwarranted investigative procedures
that have made the medical condition worse), both diagnoses may be assigned if it is clinically
useful to do so.
Boundary with secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere
In secondary mental or behavioural syndromes associated with disorders and diseases classified
elsewhere, a medical condition is judged to be causing mental or behavioural symptoms through
a direct physiological mechanism. In contrast, in psychological or behavioural factors affecting
disorders and diseases classified elsewhere, the psychological or behavioural factors are judged to
affect the manifestations, course or treatment of the medical condition. In both cases, there is a
temporal relationship between the psychological and behavioural manifestations and the medical
condition, but the presumed causal relationship is in the opposite direction in each.
Boundary with other co-occurring mental disorders and medical conditions
Whereas co-occurrence of a mental, behavioural or neurodevelopmental disorder and a medical
condition may have an impact on the management of the medical condition (e.g. medications
used in the treatment of the mental disorder interacting with medications used to treat the
medical condition), psychological or behavioural factors affecting disorders and diseases classified
elsewhere would only be diagnosed if the mental disorder itself is having a negative impact on the
manifestations, course or treatment of the medical condition.
Boundary with personality difficulty
Personality difficulty refers to pronounced, longstanding personality characteristics that may
affect treatment or health services but do not rise to the level of severity to merit a diagnosis
of personality disorder. In personality difficulty, there are difficulties in the individual’s way
of experiencing and thinking about the self, others and the world that may be intermittently
manifested in maladaptive patterns of cognitive and emotional experience and expression. The
stress associated with being diagnosed or living with a serious medical condition is one factor
that could potentially precipitate an exacerbation of personality difficulty. The category 6E40.2
Personality traits or coping style affecting disorders and diseases classified elsewhere, on the
other hand, would describe the situation in which personality difficulty has an adverse effect
on the manifestations, course or treatment of a medical condition. In clinical practice, however,
personality difficulty and a medical condition may be mutually exacerbating, in which case both
diagnoses may be assigned if it is clinically useful to do so.
Psychological or behavioural factors affecting disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

237 - Secondary mental or behavioural syndromes ass
Secondary mental or behavioural syndromes associated with disorders and diseases classified ...
651
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Secondary mental or
behavioural syndromes
associated with disorders and
diseases classified elsewhere
Secondary neurodevelopmental syndrome
6E60.0
Secondary speech or language syndrome
6E60.Y Other specified secondary neurodevelopmental
syndrome
6E60.Z Secondary neurodevelopmental syndrome,
unspecified
This grouping includes syndromes characterized by the presence of prominent psychological
or behavioural symptoms judged to be direct pathophysiological consequences of a medical
condition not classified under mental, behavioural and neurodevelopmental disorders, based on
evidence from the history, physical examination or laboratory findings. The symptoms are not
accounted for by delirium or by another mental disorder, and are not a psychologically mediated
response to a severe medical condition (e.g. adjustment disorder or anxiety symptoms in response
to being diagnosed with a life-threatening illness). In the absence of evidence of a physiological
link between the medical condition and the psychological or behavioural symptoms, a diagnosis
of a secondary mental or behavioural syndrome is typically not warranted.
Secondary mental or behavioural syndromes associated with
disorders and diseases classified elsewhere include the following:
Secondary psychotic syndrome
6E61.0
Secondary psychotic syndrome, with hallucinations
6E61.1
Secondary psychotic syndrome, with delusions
6E61.2
Secondary psychotic syndrome, with hallucinations
and delusions
6E61.3
Secondary psychotic syndrome, with unspecified
symptoms
Secondary mood syndrome
6E62.0
Secondary mood syndrome, with depressive
symptoms
6E62.1
Secondary mood syndrome, with manic symptoms
6E62.2
Secondary mood syndrome, with mixed symptoms
6E62.3
Secondary mood syndrome, with unspecified
symptoms
Secondary anxiety syndrome
6E60
6E61
6E62
6E63
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

238 - 6E60 Secondary neurodevelopmental syndrome
6E60 Secondary neurodevelopmental syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Secondary obsessive-compulsive or related syndrome
Secondary dissociative syndrome
Secondary impulse control syndrome
Secondary neurocognitive syndrome
Secondary personality change
Secondary catatonia syndrome
Other specified secondary mental or behavioural syndrome
Secondary mental or behavioural syndrome, unspecified.
Secondary neurodevelopmental syndrome
Secondary neurodevelopmental syndromes involve significant neurodevelopmental features that
do not fulfil the diagnostic requirements of any of the specific neurodevelopmental disorders
that are judged to be a direct pathophysiological consequence of a medical condition not
classified under mental and behavioural disorders, based on evidence from the history, physical
examination or laboratory findings. The appropriate diagnostic subcategory (see below) should
be used depending on whether the difficulties are related to speech or language functions or to
other areas.
Secondary speech or language syndrome
Essential (required) features
• The presence of significant difficulties in the acquisition and execution of specific speech
or language functions (e.g. errors of pronunciation, articulation or phonology), that arise
during the developmental period and persist substantially beyond the expected age, is
required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition with onset during the prenatal or developmental period, based on evidence
from history, physical examination or laboratory findings. This judgement depends on
establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of developmental difficulties (e.g. onset, remission, response of the
neurodevelopmental symptoms to treatment of the etiological medical condition) is
consistent with causation by the medical condition.
6E60
6E60.0
6E64
6E65
6E66
6E67
6E68
6E69
6E6Y
6E6Z
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
653
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
• The symptoms are not better accounted for by a primary neurodevelopmental disorder (e.g.
a developmental speech and language disorder, a disorder of intellectual development).
• The symptoms are a specific focus of clinical attention.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with developmental speech and language disorders
In developmental speech and language disorders (e.g. developmental speech sound disorder,
developmental speech fluency disorder, developmental language disorder), the individual’s ability
to understand or produce speech and language or to use language in context for the purposes
of communication is markedly below what would be expected given the individual’s age and
level of intellectual functioning. However, if the symptoms meet the diagnostic requirements of
developmental speech and language disorders and are judged to be the direct pathophysiological
consequence of a medical condition with onset during the prenatal or developmental period, a
diagnosis of secondary speech or language syndrome should be assigned instead.
Boundary with disorders of intellectual development
Individuals with a disorder of intellectual development may exhibit impaired speech production.
If speech production difficulties require separate clinical attention in the context of a disorder of
intellectual development that is judged to be due to a medical condition, an additional diagnosis
of a secondary speech or language syndrome may be assigned.
Boundary with selective mutism
Selective mutism is characterized by consistent selectivity in speaking, such that a child
demonstrates adequate speech production in specific situations (typically at home), but
predictably fails to speak in others (typically at school). Selective mutism can occur in the presence
of secondary speech or language syndrome, and both diagnoses may be assigned if warranted.
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
speech or language syndromes include:
• diseases of the nervous system (e.g. brain injury, cerebral palsy, encephalopathy, epilepsy
or seizures, myasthenia gravis, stroke);
• certain infectious or parasitic diseases (e.g. encephalitis, meningitis);
• developmental anomalies (e.g. Joubert syndrome, cleft palate, deafness);
• injury, poisoning or certain other consequences of external causes (e.g. brain injury,
concussion, traumatic haemorrhage).
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Other specified secondary neurodevelopmental syndrome
Essential (required) features
Note: presentations that meet the diagnostic requirements of disorders of intellectual
development, autism spectrum disorder or stereotyped movement disorder and are judged to be
the direct pathophysiological consequence of a medical condition are not diagnosed as secondary
neurodevelopmental syndrome because, by convention, these conditions are diagnosed regardless
of whether or not they are caused by a medical condition classified elsewhere.
• The presence of significant difficulties arising during the developmental period in the
acquisition and execution of specific intellectual, motor coordination or social functions
that do not fulfil the diagnostic requirements of disorders of intellectual development,
autism spectrum disorder or stereotyped movement disorder, and that persist substantially
beyond the expected age, is required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition with onset during the developmental period, based on evidence from history,
physical examination or laboratory findings. This judgement depends on establishing
the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of developmental difficulties (e.g. onset, remission, response of the
neurodevelopmental symptoms to treatment of the etiological medical condition) is
consistent with causation by the medical condition.
• The symptoms are not better accounted for by a neurodevelopmental disorder (e.g. a
disorder of intellectual development, autism spectrum disorder, developmental motor
coordination disorder) or the effects of a medication or substance.
• The symptoms are a specific focus of clinical attention.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with dementia with onset during the developmental period
Difficulties in the acquisition or execution of specific intellectual or social functions with onset
during the developmental period (i.e. prior to the age of 18 years) that represent a decline from
a previous level of functioning could be diagnosed as dementia if all diagnostic requirements
for dementia are met and the impairments are known to be caused by an etiology that is
specifically associated with dementia. Otherwise, if the impairments are known to be due to a
medical condition and diagnostic requirements for another neurodevelopmental disorder (e.g.
a disorder of intellectual development) are not met, a diagnosis of other specified secondary
neurodevelopmental disorder should be considered.
6E60.Y
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
655
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Boundary with disorders of intellectual development or autism spectrum disorder
If the symptoms meet the diagnostic requirements of disorders of intellectual development
or autism spectrum disorder and are judged to be the direct pathophysiological consequence
of a medical condition with onset during the prenatal or developmental period (e.g. fragile X
syndrome), both disorder of intellectual development or autism spectrum disorder and the
underlying medical condition should be diagnosed, and a diagnosis of other specified secondary
neurodevelopmental syndrome should not be assigned. However, if the diagnostic requirements
of a disorder of intellectual development or autism spectrum disorder are not fully met (e.g.
limitations in intellectual functioning are present without limitations in adaptive functioning),
and the symptoms are attributed to a medical condition with onset during the prenatal or
developmental period, a diagnosis of other specified secondary neurodevelopmental syndrome
may be assigned.
Boundary with developmental motor coordination disorder
In developmental motor coordination disorder, individuals exhibit significant delays in the
acquisition of gross and fine motor skills during the developmental period, and impairment in
the execution of coordinated motor skills that manifest in clumsiness, slowness or inaccuracy of
motor performance. If the difficulties with motor coordination are solely attributable to a disease
of nervous system (e.g. cerebral palsy, muscular dystrophy), a disease of the musculoskeletal
system or connective tissue, a sensory impairment (especially severe visual impairment) or joint
hypermobility, a diagnosis of other specified secondary neurodevelopmental syndrome should be
assigned rather than developmental motor coordination disorder.
Boundary with stereotyped movement disorder
Stereotyped movement disorder is a neurodevelopmental disorder that is characterized bythe
presence of persistent voluntary, repetitive, stereotyped movements (e.g. body rocking, head
banging) that result in significant interference with the ability to engage in normal daily activities
or result in severe bodily injury. Stereotyped movement disorder is diagnosed even if it is judged
to be caused by a medical condition classified elsewhere, and a diagnosis of other specified
secondary neurodevelopmental syndrome is not assigned.
Boundary with other neurodevelopmental disorders
The diagnosis of secondary neurodevelopmental disorder should be assigned instead of other
neurodevelopmental disorders when the symptoms are judged to be due to an underlying medical
condition. (This does not apply to disorders of intellectual development, autism spectrum disorder
or stereotyped movement disorder.)
Boundary with developmental difficulties caused by substances or medications,
including withdrawal effects
When establishing a diagnosis of other specified secondary neurodevelopmental syndrome, it
is important to rule out the possibility that a medication or substance is causing difficulties in
the acquisition or execution of specific intellectual, motor or social functions instead of – or in
addition to – an underlying medical condition. This involves first considering whether any of
the medications being used to treat the medical condition are known to cause developmental
difficulties at the dose and duration at which it has been administered. Second, a temporal
relationship between the medication use and the onset of the developmental difficulties should
be established (i.e. the developmental difficulties began after administration of the medication).
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

239 - 6E61 Secondary psychotic syndrome
6E61 Secondary psychotic syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
long-lasting intellectual impairment, poor social functioning, learning difficulties and disruptions
in attentional processes include:
• diseases of the nervous system (e.g. acquired epileptic aphasia (Landau-Kleffner syndrome),
autoimmune encephalitis, encephalopathy);
• developmental anomalies (e.g. Rett syndrome);
• diseases of the visual system (e.g. congenital blindness, vision impairment);
• endocrine, nutritional or metabolic diseases (e.g. diabetes mellitus, hyper- or
hypothyroidism, Lesch-Nyhan syndrome, lysosomal diseases such as neuronal ceroid,
lipofuscinosis or sphingolipidosis, mucolipidosis, phenylketonuria);
• injury, poisoning or certain other consequences of external causes (e.g. brain injury,
concussion, traumatic haemorrhage);
• neoplasms (e.g. neoplasms of brain or meninges).
Brain disorders and general medical conditions that have been shown to be capable of producing
long-lasting movement dysfunction or motor impairment include:
• diseases of the nervous system (e.g. cerebral palsy, Huntington disease, muscular dystrophy,
Parkinson disease, tardive dyskinesia);
• developmental anomalies (e.g. Ehlers-Danlos syndrome, Rett syndrome);
• endocrine, nutritional or metabolic diseases (e.g. Lesch-Nyhan syndrome).
Secondary neurodevelopmental syndrome, unspecified
Secondary psychotic syndrome
Essential (required) features
• The presence of prominent hallucinations and/or delusions is required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition, based on evidence from the history, physical examination or laboratory findings.
This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of the hallucinations and/or delusions (e.g. onset, remission, response of the
psychotic symptoms to treatment of the etiological medical condition) is consistent with
causation by the medical condition.
6E60.Z
6E61
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
657
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
• The symptoms are not better accounted for by delirium, dementia, another mental
disorder (e.g. schizophrenia or another primary psychotic disorder, a mood disorder)
or the effects of a medication or substance, including withdrawal effects.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
Secondary psychotic syndrome, with hallucinations
Essential (required) features
• All diagnostic requirements for secondary psychotic syndrome are met.
• The presentation is characterized by prominent hallucinations without prominent
delusions.
Secondary psychotic syndrome, with delusions
Essential (required) features
• All diagnostic requirements for secondary psychotic syndrome are met.
• The presentation is characterized by prominent delusions without prominent hallucinations.
Secondary psychotic syndrome, with hallucinations and delusions
Essential (required) features
• All diagnostic requirements for secondary psychotic syndrome are met.
• The presentation is characterized by both prominent hallucinations and prominent
delusions.
Secondary psychotic syndrome, with unspecified symptoms
6E61.0
6E61.1
6E61.2
6E61.3
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with schizophrenia and other primary psychotic disorders
Determining whether psychotic symptoms are due to a medical condition as opposed to
manifestations of a primary mental disorder is often difficult because the clinical presentations
may be similar. Establishing the presence of a potentially explanatory medical condition that can
cause hallucinations or delusions and the temporal relationship between the medical condition
and the psychotic symptoms is critical in diagnosing secondary psychotic syndrome. A list of
medical conditions that have been reported to cause psychotic symptoms is included below
(p. 659), but the strength of the association varies according to the medical condition. Secondary
psychotic syndrome is often characterized by clinical features that would be atypical for a primary
psychotic disorder such as later age of onset, rapid occurrence of clouding of consciousness, and
accompanying cognitive, neurological or medical symptoms. In secondary psychotic syndrome,
disorganized thinking (formal thought disorder) is not typically present, delusions are more often
simple and fragmented, and hallucinations are more often visual, tactile, olfactory or gustatory
rather than auditory.
Boundary with psychotic symptoms that are precipitated by the stress of being
diagnosed with a medical condition
Depending on the nature of the medical condition (e.g. a life-threatening type of cancer, a
potentially fatal infection) or its onset (e.g. a heart attack, a stroke, a severe injury), being diagnosed
with a severe medical condition can be experienced as a traumatic event, which could trigger the
development of psychotic symptoms (e.g. hallucinations and delusions) in susceptible individuals
(e.g. individuals with a pre-existing psychotic disorder, a dissociative disorder or a personality
disorder). If the psychotic symptoms are part of the presentation of a diagnosable mental disorder
that is judged to be precipitated or exacerbated by the stress of being diagnosed or coping with a
medical condition, the appropriate mental disorder (e.g. acute and transient psychotic disorder,
post-traumatic stress disorder, recurrent depressive disorder) should be diagnosed rather than
secondary psychotic syndrome.
Boundary with delirium due to disease classified elsewhere
Hallucinations or delusions can occur in the context of delirium due to disease classified elsewhere.
Delirium is characterized by disturbed attention (i.e. reduced ability to direct, focus, sustain
and shift attention) and awareness (i.e. reduced orientation to the environment) that develops
over a short period of time and tends to fluctuate during the course of a day, accompanied by
other cognitive impairments such as memory deficit, disorientation or impairment in language,
visuospatial ability or perception. Disturbed attention and awareness and severe cognitive
impairment are not features of secondary psychotic syndrome. If the psychotic symptoms are
judged to be better explained by delirium due to disease classified elsewhere, an additional
diagnosis of secondary psychotic syndrome is not warranted.
Boundary with dementia
Hallucinations or delusions can occur in the context of dementia, which is characterized by a
decline from a previous level of cognitive functioning with impairment in two or more cognitive
domains (e.g. memory, executive functions, attention, language, social cognition and judgement,
psychomotor speed, visuoperceptual or visuospatial abilities). In contrast, secondary psychotic
syndrome is not accompanied by marked cognitive impairment. The presence of hallucinations
or delusions in the context of dementia can be recorded using the psychotic symptoms in dementia
specifier. If the psychotic symptoms are judged to be due to the same medical condition as is
causing the dementia, an additional diagnosis of secondary psychotic syndrome is not warranted.
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

24 - Specifier scales for symptomatic manifestatio
Specifier scales for symptomatic manifestations of primary psychotic disorders
191
Specifier scales for symptomatic manifestations of primary psychotic disorders
6A25.0
These domains are:
ICD-11 includes the option of providing a specification of the level of severity for six symptom
domains for the disorders included in schizophrenia and other primary psychotic disorders.
6A25.3
6A25.4
Manic mood symptoms
Psychomotor symptoms
6A25.5
Cognitive symptoms
6A25.1
Negative symptoms
6A25.2
Depressive mood symptoms
Specifier scales for
symptomatic manifestations of
primary psychotic disorders
Positive symptoms
The contribution of each of these symptom domains can be recorded in the form of specifiers,
which can be rated as not present/none (XS8H), mild (XS5W), moderate (XS0T) or severe (XS25),
using the anchor points and descriptions provided in Tables 6.6–6.12 below. The ratings should be
made based on the severity of the symptoms corresponding to that domain during the past week.
Each domain that contributes significantly to the individual clinical presentation should be rated.
As many symptom specifiers should be applied as necessary to describe the current clinical
presentation accurately. A symptom domain can also be recorded with unspecified severity – for
example, if symptoms corresponding to a particular domain are present but insufficient information
is available in order to rate their severity. In this case, the code for the symptom domain would be
recorded (e.g. 6A25.0) without a severity rating.
In cases where multiple symptoms fall within a particular domain, the rating should reflect the
most severe symptom within that domain. For example, hallucinations and delusions are both
part of the positive symptoms domain. A person may experience hallucinations that result in
minimal distress (indicative of mild positive symptoms) and delusions that affect the person’s
behaviour but not to the point of impairing their functioning (indicative of moderate positive
symptoms). In that case, the person’s positive symptoms should be rated as moderate. Note that
individuals with primary psychotic disorders typically do not present with all the symptoms that
are part of a given specifier domain. For example, in the positive symptoms domain, a person may
present with only hallucinations, only delusions, both or neither. The descriptions corresponding
to each rating in the tables below are intended to convey examples of symptom presentations
that would justify a rating at a particular level of severity; they are not intended to be used as
required criteria.
Specifier scales for symptomatic manifestations of primary psychotic disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Note that the mild, moderate and severe ratings for the depressive mood symptoms specifier are not
equivalent to the corresponding diagnostic requirements for a mild, moderate or severe depressive
episode. In other words, a rating of mild for depressive mood symptoms in the psychotic disorder
specifiers does not indicate that the individual meets the requirements for a mild depressive
episode. The same is true of the manic mood symptoms specifier. The rating of depressive and
manic mood symptoms in these specifiers indicates the severity of depressed, elevated, or irritable
mood, and does not include other symptoms (e.g. disrupted sleep, anhedonia, appetite change)
that can occur as a part of mood episodes.
Symptom specifier ratings are intended to characterize the current clinical presentation among
individuals diagnosed with schizophrenia and other primary psychotic disorders, and should
not be used in individuals without such a diagnosis. Symptoms attributable to the direct
pathophysiological consequences of a comorbid medical condition or injury not classified under
mental, behavioural and neurodevelopmental disorders (e.g. a brain tumour or traumatic brain
injury), or to the direct physiological effects of substances or medications (including withdrawal
effects), should not be included in the specifier ratings. However, in individuals with schizophrenia
and other primary psychotic disorders, the specific etiology of symptoms is often unclear (e.g.
whether a mood symptom is due to the psychotic disorder or a result of substance use). In these
cases, the relevant symptom should be considered in making the specifier rating until it becomes
clear that the pathogenesis of the symptom is unrelated to the primary psychotic disorder.
Severity
Anchor points
None
XS8H
No significant symptoms from the respective domain have been present during
the past week
Mild
XS5W
Symptoms in the domain have been present during the past week, but these
are minimal in number or do not have a substantial degree of impact. Everyday
functioning is not affected by these symptoms, or is affected only minimally.
No significant negative social or personal consequences have occurred as a
consequence of the symptoms. The symptoms may be intermittent and show
fluctuations in severity, and there may be periods during which the symptoms
are absent. Compared to other individuals with similar symptoms, the severity of
symptoms in the domain is in the mildest third.
Moderate
XS0T
A greater number of symptoms in the domain have been present during the
past week, or a smaller number of symptoms that have a substantial degree of
impact. Everyday functioning may be moderately affected by the symptoms.
There are negative social or personal consequences of the symptoms, but these
are not severe. Most of the symptoms are present the majority of the time.
Compared to other individuals with similar symptoms, the severity of symptoms
in the domain is in the middle third.
Severe
XS25
Many symptoms in the domain have been present during the past week, or
a smaller number that have a severe or pervasive degree of impact (i.e. they
are intense and frequent or constant). Everyday functioning is persistently
impaired due to the symptoms. There are serious negative social or personal
consequences. Compared to other individuals with similar symptoms, the
severity of symptoms in the domain is in the most severe third.
Severity unspecified
Symptoms from the respective domain have been present during the past week,
but it is not possible to make a severity rating based on the available information.
Table 6.6. Symptomatic manifestations of primary psychotic disorders:
anchor points and descriptions for specifier severity ratings
Specifier scales for symptomatic manifestations of primary psychotic disorders
193
Specifier scales for symptomatic manifestations of primary psychotic disorders
This specifier may be used together with a diagnosis from the grouping of schizophrenia and
other primary psychotic disorders to indicate the degree to which positive psychotic symptoms
are a prominent part of the current clinical presentation (see Table 6.7). Positive symptoms
include delusions, hallucinations (most commonly verbal auditory hallucinations), disorganized
thinking (formal thought disorder such as loose associations, thought derailment or incoherence),
disorganized behaviour (behaviour that appears bizarre, purposeless and not goal-directed), and
experiences of passivity and control (the experience that one’s feelings, impulses or thoughts
are under the control of an external force). Abnormal psychomotor behaviour (e.g. catatonic
restlessness or agitation, waxy flexibility, negativism) is not included in this domain but instead
would be rated in the 6A25.4 Psychomotor symptoms domain below.
The rating should be made based on the severity of positive symptoms during the past week.
Positive symptoms
Severity
Anchor points
None
6A25.0&XS8H
No significant positive symptoms have been present during the past week
Mild
6A25.0&XS5W
Example symptoms (not all are required)
Delusions
The person believes the delusion (lack of reality testing), but does not feel
pressure to act upon it, and the delusion leads to minimal distress.
Hallucinations
Hallucinations are recurrent but relatively infrequent, and the person expresses
only minimal distress regarding their content.
Experiences of passivity and control
Some distortions of self-experience are present, such as feeling that one’s
thoughts are not one’s own, but these are relatively infrequent and there is only
minimal associated distress.
Disorganized thinking
Some circumstantial or tangential thought processes are present, but for
the most part the individual is able to convey the point of the intended
communication.
Disorganized behaviour
Infrequent episodes of purposeless behaviour that is not goal-directed and
causes only minimal impairment in functioning are present.
Moderate
6A25.0&XS0T
Example symptoms (not all are required)
Delusions
The person’s behaviour is clearly affected by the delusional beliefs but the
person’s behavioural response does not significantly impair functioning (e.g.
a person with persecutory delusions is watchful of their surroundings but
continues to venture outside).
Hallucinations
Hallucinations are relatively frequent and may be distressing at times but are
tolerated at other times, and do not persistently preoccupy the person. The
content of hallucinations may prompt action, but the person only inconsistently
or occasionally responds, and these actions do not put the person or others at
risk of harm.
Table 6.7. Rating scale for positive symptoms in primary psychotic
disorders
Specifier scales for symptomatic manifestations of primary psychotic disorders | Positive symptoms
6A25.0
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.7. contd
Negative symptoms
This specifier may be used together with a diagnosis from the grouping of schizophrenia and
other primary psychotic disorders to indicate the degree to which negative psychotic symptoms
are a prominent part of the current clinical presentation (see Table 6.8). Negative symptoms
include constricted, blunted or flat affect; alogia or paucity of speech; avolition (general lack
of drive, or lack of motivation to pursue meaningful goals); asociality (reduced or absent
engagement with others and interest in social interaction) and anhedonia (inability to experience
pleasure from normally pleasurable activities). To be considered negative psychotic symptoms,
relevant symptoms should not be entirely attributable to depression or to an understimulating
environment, be a direct consequence of a positive symptom (e.g. persecutory delusions causing a
person to become socially isolated due to fear of harm), or be attributable to the direct physiological
effects of substances or medications, including withdrawal effects. Catatonia, including catatonic
mutism, should be considered as part of the 6A25.4 Psychomotor symptoms domain below
rather than here.
Severity
Anchor points
Experiences of passivity and control
Distortions of self-experience are relatively frequent and lead to some
behaviours to ward against alteration of thoughts (e.g. superstitious rituals) or
noticeable distress.
Disorganized thinking
Evidence of frequent circumstantial or tangential thought process that impairs
the individual’s ability to convey the point of the communication.
Disorganized behaviour
Frequent episodes of purposeless behaviour that is not goal-directed and that
causes some impairment in functioning.
Severe
6A25.0&XS25
Example symptoms (not all are required)
Delusions
The person is preoccupied with delusional beliefs that dictate many of their
actions and significantly impair functioning (e.g. a person with persecutory
delusions refuses to eat most food because of a conviction that food has been
poisoned).
Hallucinations
The person is markedly distressed or preoccupied by frequent hallucinations, or
there are recurrent hallucinations that prompt potentially harmful behaviour to
which the person feels compelled to respond.
Experiences of passivity and control
Distortions of self-experience are markedly distressing, and significantly affect
the individual’s behaviour (e.g. wearing a hat made of aluminium foil to prevent
thought broadcasting).
Disorganized thinking
Loose associations in thought processes are present that are so severe that
speech is mostly incoherent.
Disorganized behaviour
Purposeless behaviour that is not goal-directed dominates the individual’s
behavioural repertoire, and causes severe impairment in functioning.
Severity unspecified
6A25.0
Positive symptoms have been present during the past week, but it is not possible
to make a severity rating based on the available information.
Specifier scales for symptomatic manifestations of primary psychotic disorders | Negative symptoms
6A25.1
195
Specifier scales for symptomatic manifestations of primary psychotic disorders
The rating should be made based on the severity of negative symptoms during the past week.
Depressive mood symptoms
This specifier may be used together with a diagnosis from the grouping of schizophrenia and
other primary psychotic disorders to indicate the degree to which depressive mood symptoms are
a prominent part of the current clinical presentation (see Table 6.9). The specifier refers only to
depressive mood symptoms, as reported by the individual (feeling down, sad) or as observed by
the clinician (e.g. tearful, defeated appearance). The severity of associated non-mood symptoms
of a depressive episode (e.g. anhedonia or other negative symptoms, changes in sleep or appetite)
should not be considered in making a rating for this specifier. In this regard, the depressive mood
symptoms specifier is different from the severity rating applied to a depressive episode (see p. 216).
If suicidal ideation is present, a rating of moderate or severe depressive mood symptoms should
automatically be applied (see below). This specifier may be used regardless of whether the
depressive symptoms meet the diagnostic requirements for a depressive episode.
Severity
Anchor points
None
6A25.1&XS8H
No significant negative symptoms have been present during the past week.
Mild
6A25.1&XS5W
Example symptoms (not all are required)
Blunted emotional experience or expression is present, with subtle but detectable
affective changes. Initiation of speech is limited, but the individual is responsive
to questions. The person shows little interest in external events, but exhibits
sufficient motivation to engage in basic activities of daily living or to complete a
task when prompted
Moderate
6A25.1&XS0T
Example symptoms (not all are required)
Flat emotional expression is present. Initiation of speech for purposes other
than indicating immediate needs and desires is minimal, but the individual is
responsive to questions with terse phrases. Lack of volition leads to neglect of
hygiene or required activities, but the person will complete them with significant
prompting.
Severe
6A25.1&XS25
Example symptoms (not all are required)
The person reports feeling empty or robotic most of the time. Generally the
individual does not initiate speech, even to indicate immediate needs and desires.
The person is not capable of initiating behaviour even with significant prompting,
which may lead to serious neglect of self-care to the extent that it puts the
person at risk of harm (e.g. infrequently taking life-sustaining medication).
Severity unspecified
6A25.1
Negative symptoms have been present during the past week, but it is not
possible to make a severity rating based on the available information.
Table 6.8. Rating scale for negative symptoms in primary psychotic disorders
Specifier scales for symptomatic manifestations of primary psychotic disorders | Depressive mood symptoms
6A25.2
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
The rating should be made based on the severity of depressive mood symptoms during the
past week.
Table 6.9. Rating scale for depressive mood symptoms in primary psychotic
disorders
Severity
Anchor points
None
6A25.2&XS8H
No significant depressive mood symptoms have been present during the past
week
Mild
6A25.2&XS5W
The person expresses significant depressed mood, but there are intermittent
periods of relief. The depressive symptoms have some, but not considerable,
impact on at least some areas of personal, social or occupational functioning.
Moderate
6A25.2&XS0T
The depressed mood is present continually, although its intensity may vary.
Suicidal ideation may accompany the depressed mood when it is more intense.
The depressive symptoms cause considerable difficulty with personal, social or
occupational functioning.
Severe
6A25.2&XS255
The intensity of the depressed mood is overwhelming to the person. This level
of severity may be indicated by intense suicidal ideation or suicide attempts. The
depressive symptoms seriously affect all areas of functioning (personal, social
and occupational) to such an extent that the person is unable to function, except
to a very limited degree.
Severity unspecified
6A25.2
Depressive mood symptoms have been present during the past week, but it is
not possible to make a severity rating based on the available information.
Manic mood symptoms
This specifier may be used together with a diagnosis from the grouping of schizophrenia and
other primary psychotic disorders to indicate the extent to which manic mood symptoms are
a prominent part of the clinical presentation (see Table 6.10). The specifier includes elevated,
euphoric, irritable or expansive mood states, including rapid changes among different mood
states (i.e. mood lability). It also includes increased subjective experience of energy, which may be
accompanied by increased goal-directed activity. The severity of associated non-mood symptoms
of a manic or hypomanic episode (e.g. decreased need for sleep, distractibility) should not be
considered in making a rating for this specifier. Increased non-goal-directed psychomotor activity
should be considered as part of the 6A25.4 Psychomotor symptoms domain below rather than
here. This specifier may be used regardless of whether the manic symptoms meet the diagnostic
requirements for a manic episode.
The rating should be made based on the severity of manic mood symptoms during the past week.
Specifier scales for symptomatic manifestations of primary psychotic disorders | Manic mood symptoms
6A25.3
197
Specifier scales for symptomatic manifestations of primary psychotic disorders
Table 6.10. Rating scale for manic mood symptoms in primary
psychotic disorders
Severity
Anchor points
None
6A25.3&XS8H
No significant manic mood symptoms have been present during the past week.
Mild
6A25.3&XS5W
Hypomanic elevation of mood or increased irritability is present. The hypomanic
symptoms do not cause marked impairment in personal, social or occupational
functioning.
Moderate
6A25.3&XS0T
Marked elevation of mood, irritability or subjective energy level is present.
The manic symptoms cause considerable difficulty with personal, social or
occupational functioning.
Severe
6A25.3&XS25
Extreme elevation of mood or irritability is present that results in hazardous,
dangerous or markedly inappropriate behaviour to a degree that intensive
supervision is required.
Severity unspecified
6A25.3
Manic mood symptoms have been present during the past week, but it is not
possible to make a severity rating based on the available information.
Psychomotor symptoms
This specifier may be used together with a diagnosis from the grouping of schizophrenia and
other primary psychotic disorders to indicate the degree to which psychomotor symptoms are
a prominent part of the clinical presentation (see Table 6.11). Psychomotor symptoms include
psychomotor agitation or increased motor activity, usually manifested in purposeless behaviours
such as fidgeting, shifting, fiddling, inability to sit or stand still, wringing of the hands, stereotypy
and grimacing. Psychomotor symptoms also include psychomotor retardation (a visible
generalized slowing of movements and speech), as well as catatonic symptoms such as extreme
restlessness with purposeless motor activity to the point of exhaustion, posturing, waxy flexibility,
negativism, mutism or stupor. To be considered psychomotor symptoms for the purpose of
this specifier rating, symptoms should not be attributable to a neurodevelopmental disorder or
disease of the nervous system, or to the direct physiological effects of substances or medications,
including withdrawal effects. If the full syndrome of catatonia is present, the diagnosis of 6A40
Catatonia associated with another mental disorder (p. 202) should also be assigned.
The rating should be made based on the severity of psychomotor symptoms during the past week.
Specifier scales for symptomatic manifestations of primary psychotic disorders | Psychomotor symptoms
6A25.4
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Table 6.11. Rating scale for psychomotor symptoms in primary psychotic disorders
Severity
Anchor points
None
6A25.4&XS8H
No significant psychomotor symptoms have been present during the past week
Mild
6A25.4&XS5W
The majority of the time the person exhibits a normal level of activity, but there
are occasional periods of psychomotor excitation or slowing. Psychomotor
symptoms do not interfere significantly with important personal, social or
occupational functioning.
Moderate
6A25.4&XS0T
The person experiences frequent periods of marked psychomotor agitation
or retardation, but psychomotor symptoms are not continuous. Psychomotor
symptoms interfere significantly with important personal, social or occupational
functioning.
Severe
6A25.4&XS25
The individual experiences severe and nearly continuous psychomotor agitation
or slowing, which may include the full syndrome of catatonia (see p. 202). The
psychomotor symptoms are sufficiently severe to be potentially harmful to the
person or others (e.g. agitation to the point of severe physical exhaustion, stupor
that prevents the person from feeding themselves).
Severity unspecified
6A25.4
Psychomotor symptoms have been present during the past week, but it is not
possible to make a severity rating based on the available information.
Cognitive symptoms
This specifier may be used together with a diagnosis from the grouping of schizophrenia and other
primary psychotic disorders to indicate the degree to which cognitive impairment is a prominent
aspect of the clinical presentation (see Table 6.12). Deficits may appear in any of the following
cognitive domains: speed of processing, attention/concentration, orientation, judgement,
abstraction, verbal or visual learning, or working memory. The cognitive impairment is not
attributable to a neurodevelopmental disorder, to delirium or another neurocognitive disorder,
or to the direct effects of a substance or medication on the central nervous system, including
withdrawal effects. When available, the severity rating for this domain should be based on the
results of locally validated, standardized neuropsychological assessments, but such measures are
not available in all settings and are not required to provide a rating.
The rating should be made based on the severity of cognitive symptoms during the past week.
Specifier scales for symptomatic manifestations of primary psychotic disorders | Cognitive symptoms
6A25.5
199
Specifier scales for symptomatic manifestations of primary psychotic disorders
Table 6.12. Rating scale for cognitive symptoms in primary psychotic disorders
Severity
Anchor points
None
6A25.5&XS8H
No significant cognitive symptoms have been present during the past week
Mild
6A25.5&XS5W
The person has minor difficulties in cognition (e.g. difficulty with recall during the
interview, drifting concentration, showing some disorientation to time but not
person or place). Everyday functioning is largely unimpaired by the difficulties
Moderate
6A25.5&XS0T
The individual shows clear difficulties in cognition (e.g. impaired or inconsistent
recall for some autobiographical information, inability to perform some basic
operations that are expected of the person’s educational attainment and level of
intellectual functioning – such as simple calculation tasks, disrupted orientation
for time and place but intact for person, difficulty learning or retaining new
information). Everyday functioning is impaired as a result, but only some external
assistance is necessary.
Severe
6A25.5&XS25
The person shows pronounced difficulties in cognition (e.g. severe deficits in
verbal memory or other cognitive tasks relative to educational attainment and
level of intellectual functioning, substantial difficulty with concentration and
paying attention to what the rater asks during the interview, difficulty formulating
plans to accomplish a specific objective, inability to consider alternative solutions
to problems, grossly disturbed orientation). The problems severely interfere
with everyday functioning, leading to the necessity of considerable external
assistance.
Severity unspecified
6A25.5
Cognitive symptoms have been present during the past week, but it is not
possible to make a severity rating based on the available information.
Specifier scales for symptomatic manifestations of primary psychotic disorders | Cognitive symptoms
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

240 - 6E62 Secondary mood syndrome
6E62 Secondary mood syndrome
659
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Boundary with psychotic symptoms caused by substances or medications,
including withdrawal effects
When establishing a diagnosis of secondary psychotic syndrome, it is important to rule out the
possibility that a medication or substance is causing the hallucinations or delusions instead of
– or in addition to – an underlying medical condition. This involves first considering whether
any of the medications being used to treat the medical condition are known to cause psychotic
symptoms at the dose and duration at which it has been administered. Second, a temporal
relationship between the medication use and the onset of the psychotic symptoms should be
established (i.e. the psychotic symptoms began after administration of the medication and/or
remitted once the medication was discontinued). The same reasoning applies to individuals
with a medical condition and psychotic symptoms who are also using a psychoactive substance
known to cause hallucinations or delusions, in the context of either intoxication or withdrawal
(e.g. visual hallucinations during sedative, hypnotic or anxiolytic withdrawal; paranoid delusions
during cocaine intoxication). In such cases, if the intensity or duration of the psychotic symptoms
is substantially in excess of psychotic-like disturbances of perception, cognition or behaviour
that are characteristic of the substance-specific intoxication or withdrawal syndromes, then
substance-induced psychotic disorder is the appropriate diagnosis, applying the appropriate
category corresponding to the substance involved.
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
psychotic syndromes include:
• diseases of the nervous system (e.g. encephalitis, encephalopathy, genetic prion disease,
intracerebral haemorrhage, Lewy body disease, migraine, movement disorders such as
Huntington disease or Friedreich ataxia, multiple sclerosis, seizures, stroke);
• certain infectious or parasitic diseases (e.g. neurosyphilis);
• diseases of the immune system (e.g. systemic lupus erythematosus);
• endocrine, nutritional or metabolic diseases (e.g. hyper- and hypoadrenalism, hyper- and
hypoparathyroidism, hyper- and hypothyroidism, hypo-osmolality or hyponatraemia,
hypoglycaemia, porphyrias, vitamin B1 or vitamin B12 deficiency, Wilson disease);
• injury, poisoning or certain other consequences of external causes (e.g. brain injury,
concussion, traumatic haemorrhage, injury of optic or acoustic nerve);
• neoplasms (e.g. neoplasms of brain or meninges).
Secondary mood syndrome
Essential (required) features
• The presence of prominent depressive, manic or mixed mood symptoms is required
for diagnosis.
6E62
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition, based on evidence from the history, physical examination or laboratory findings.
This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of the mood symptoms (e.g. onset, remission, response of the mood symptoms
to treatment of the etiological medical condition) is consistent with causation by the
medical condition.
• The symptoms are not better accounted for by delirium, dementia, another mental
disorder (e.g. a depressive disorder, bipolar type I or bipolar type II disorder, cyclothymic
disorder, catatonia) or the effects of a medication or substance, including withdrawal
effects.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
Secondary mood syndrome, with depressive symptoms
Essential (required) features
• All diagnostic requirements for secondary mood syndrome are met.
• The presentation is characterized by prominent depressive symptoms without prominent
manic symptoms.
Secondary mood syndrome, with manic symptoms
Essential (required) features
• All diagnostic requirements for secondary mood syndrome are met.
• The presentation is characterized by prominent manic symptoms without prominent
depressive symptoms.
Secondary mood syndrome, with mixed symptoms
Essential (required) features
• All diagnostic requirements for secondary mood syndrome are met.
• The presentation is characterized by both prominent depressive and prominent
manic symptoms.
6E62.0
6E62.1
6E62.2
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
661
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Secondary mood syndrome, with unspecified symptoms
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with mood disorders
Determining whether mood symptoms are due to a medical condition as opposed to
manifestations of a primary mental disorder is often difficult because the clinical presentations
may be similar. Establishing the presence of a potentially explanatory medical condition that
can cause mood symptoms and the temporal relationship between the medical condition and
the mood symptoms is critical in diagnosing secondary mood syndrome. If the clinical features
are atypical for mood disorders (e.g. atypical age of onset or course, absence of family history),
secondary mood syndrome is more likely.
Boundary with mood symptoms that are precipitated by the stress of being
diagnosed with a medical condition
Depending on the nature of the medical condition (e.g. a life-threatening type of cancer, a
potentially fatal infection) or its onset (e.g. a heart attack, a stroke, a severe injury), mood
symptoms can occur as a part of a psychological response to being diagnosed and/or having to
cope with a severe medical condition. In the absence of evidence of a physiological link between
the medical condition and the mood symptoms, the appropriate mental disorder (e.g. adjustment
disorder, a mood disorder) rather than secondary mood syndrome should be diagnosed.
Boundary with delirium due to disease classified elsewhere
Mood symptoms can occur in the context of delirium due to disease classified elsewhere.
Delirium is characterized by disturbed attention (i.e. reduced ability to direct, focus, sustain
and shift attention) and awareness (i.e. reduced orientation to the environment) that develops
over a short period of time and tends to fluctuate during the course of a day, accompanied by
other cognitive impairment such as memory deficit, disorientation or impairment in language,
visuospatial ability or perception. In contrast, mood symptoms in secondary mood syndrome
occur in the absence of disturbed attention or severe cognitive impairment. If mood symptoms
are judged to be better explained by delirium due to disease classified elsewhere, an additional
diagnosis of secondary mood syndrome is not warranted.
Boundary with dementia
Mood symptoms can occur in the context of dementia, which is characterized by a decline from
a previous level of cognitive functioning with impairment in two or more cognitive domains (e.g.
memory, executive functions, attention, language, social cognition and judgement, psychomotor
speed, visuoperceptual or visuospatial abilities). In contrast, secondary mood syndrome is not
accompanied by marked cognitive impairment. The presence of mood symptoms in the context of
dementia can be recorded using the mood symptoms in dementia specifier. If the mood symptoms
are judged to be due to the same medical condition as is causing the dementia, an additional
diagnosis of secondary mood syndrome is not warranted.
6E62.3
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with secondary catatonia syndrome
Certain symptoms of secondary catatonia syndrome are similar to those observed during
manic, depressive or mixed episodes (e.g. stupor or mutism in secondary catatonia is similar
to psychomotor retardation in a depressive episode; agitation or impulsivity in secondary
catatonia syndrome is similar to increased activity and impulsive reckless behaviour in a manic
episode). In secondary catatonia syndrome, these symptoms occur in conjunction with other
catatonic symptoms (e.g. abnormal psychomotor activity such as mannerisms, waxy flexibility or
posturing), which are not characteristic of secondary mood syndrome.
Boundary with mood symptoms caused by substances or medications, including
withdrawal effects
When establishing a diagnosis of secondary mood syndrome, it is important to rule out the
possibility that a medication or substance is causing the mood symptoms instead of –or in
addition to – an underlying medical condition. This involves first considering whether any of
the medications being used to treat the medical condition are known to cause depressive or
manic symptoms (e.g. steroids or alpha-interferon) at the dose and duration at which it has been
administered. Second, a temporal relationship between the medication use and the onset of the
mood symptoms should be established (i.e. the mood symptoms began after administration of the
medication and/or remitted once the medication was discontinued). The same reasoning applies
to individuals with a medical condition and mood symptoms who are also using a psychoactive
substance known to cause mood symptoms, in the context of either intoxication or withdrawal
(e.g. euphoric mood due to stimulant intoxication, dysphoric mood due to cocaine withdrawal).
In such cases, if the intensity or duration of the mood symptoms is substantially in excess of
mood disturbances that are characteristic of the substance-specific intoxication or withdrawal
syndrome, then substance-induced mood disorder is the appropriate diagnosis, applying the
appropriate category corresponding to the substance involved.
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
depressive mood syndromes include:
• diseases of the nervous system (e.g. cerebrovascular disease, Huntington disease, normalpressure hydrocephalus, multiple sclerosis, Parkinson disease, stroke);
• certain infectious or parasitic diseases (candidosis, HIV disease, Lyme borreliosis,
toxoplasmosis);
• diseases of the immune system (e.g. systemic lupus erythematosus);
• endocrine, nutritional or metabolic diseases (e.g. Cushing syndrome, hypercalcaemia,
hyperglycaemia, hypermagnesaemia, hypoadrenalism, hypothyroidism, iron deficiency);
• injury, poisoning or certain other consequences of external causes (e.g. brain injury,
concussion, traumatic haemorrhage);
• neoplasms (e.g. malignant neoplasm of pancreas leading to a paraneoplastic disorder of
the nervous system, brain or spinal cord).
Brain disorders and general medical conditions that have been shown to be capable of producing
manic mood syndromes include:
• diseases of the nervous system (e.g. movement disorders such as Huntington disease,
multiple sclerosis, seizures, stroke);
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

241 - 6E63 Secondary anxiety syndrome
6E63 Secondary anxiety syndrome
663
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
• certain infectious or parasitic diseases (e.g. neurosyphilis);
• diseases of the immune system (e.g. systemic lupus erythematosus);
• endocrine, nutritional or metabolic diseases (e.g. hyperadrenalism, hypocalcaemia,
hypomagnesaemia, thyrotoxicosis, Wilson disease);
• injury, poisoning or certain other consequences of external causes (e.g. brain injury,
concussion, traumatic haemorrhage, injury of optic or acoustic nerve);
• neoplasms (e.g. neoplasms of brain or meninges).
Secondary anxiety syndrome
Essential (required) features
• The presence of prominent anxiety symptoms (e.g. excessive worry, intense fear that is out
of proportion to actual danger, panic attacks) is required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition, based on evidence from the history, physical examination or laboratory
findings (as opposed to being a psychological reaction to having the medical condition).
This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of the anxiety symptoms (e.g. onset, remission, response of the anxiety
symptoms to treatment of the etiological medical condition) is consistent with causation
by the medical condition.
• The symptoms are not better accounted for by delirium, dementia, another mental
disorder (e.g. anxiety and fear-related disorders, mood disorders, disorders specifically
associated with stress, obsessive-compulsive and related disorders) or the effects of a
medication or substance, including withdrawal effects.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with anxiety and fear-related disorders
Determining whether anxiety symptoms are due to a medical condition as opposed to
manifestations of a mental disorder is often difficult because the clinical presentations may
be similar. In some cases, the anxiety symptoms may reach the point of warranting a separate
diagnosis of an anxiety or fear-related disorder, or a pre-existing anxiety or fear-related disorder
may be exacerbated. Diagnosing secondary anxiety syndrome depends on establishing the
presence of a medical condition that can cause anxiety symptoms and a temporal relationship
between the medical condition and the anxiety symptoms. If the clinical features are atypical for
anxiety and fear-related disorders (e.g. a new onset of unexpected panic attacks in an older adult),
secondary anxiety syndrome is more likely.
6E63
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with anxiety symptoms that are precipitated by the stress of being
diagnosed with or worrying about a medical condition
Depending on the nature of the medical condition (e.g. a life-threatening type of cancer,
a potentially fatal infection) or its onset (e.g. a heart attack, a stroke, a severe injury), anxiety
symptoms can occur as a part of a psychological response to being diagnosed and/or having to
cope with a severe medical condition. In the absence of evidence of a physiological link between
the medical condition and the anxiety symptoms, a diagnosis of secondary anxiety syndrome is
not warranted. Instead, the appropriate mental disorder can be diagnosed (e.g. an anxiety or fearrelated disorder, adjustment disorder, hypochondriasis).
Boundary with delirium due to disease classified elsewhere
Anxiety symptoms can occur in the context of delirium due to disease classified elsewhere.
Delirium is characterized by disturbed attention (i.e. reduced ability to direct, focus, sustain
and shift attention) and awareness (i.e. reduced orientation to the environment) that develops
over a short period of time and tends to fluctuate during the course of a day, accompanied by
other cognitive impairment such as memory deficit, disorientation or impairment in language,
visuospatial ability or perception. In contrast, panic attacks or other anxiety symptoms in
secondary anxiety syndrome occur in the absence of disturbed attention or severe cognitive
impairment. If the anxiety symptoms are judged to be better explained by delirium due to disease
classified elsewhere, an additional diagnosis of secondary anxiety syndrome is not warranted.
Boundary with dementia
Anxiety symptoms can occur in the context of dementia, which is characterized by a decline from
a previous level of cognitive functioning with impairment in two or more cognitive domains (e.g.
memory, executive functions, attention, language, social cognition and judgement, psychomotor
speed, visuoperceptual or visuospatial abilities). In contrast, secondary anxiety syndrome is not
accompanied by marked cognitive impairment. The presence of anxiety symptoms in the context
of dementia can be recorded using the anxiety symptoms in dementia specifier. If the anxiety
symptoms are judged to be due to the same medical condition as is causing the dementia, an
additional diagnosis of secondary anxiety syndrome is not warranted.
Boundary with anxiety symptoms caused by substances or medications, including
withdrawal effects
When establishing a diagnosis of secondary anxiety syndrome, it is important to rule out the
possibility that a medication or substance is causing the anxiety symptoms instead of – or in
addition to – an underlying medical condition. This involves first considering whether any of the
medications being used to treat the medical condition are known to cause anxiety symptoms at
the dose and duration at which it has been administered. Second, a temporal relationship between
the medication use and the onset of the anxiety symptoms should be established (i.e. the anxiety
symptoms began after administration of the medication and/or remitted once the medication was
discontinued). The same reasoning applies to individuals with a medical condition and anxiety
symptoms who are also using a psychoactive substance known to cause anxiety, in the context
of either intoxication or withdrawal (e.g. panic attacks during anxiolytic or opioid withdrawal,
physiological symptoms of excessive autonomic arousal in stimulant intoxication). In such
cases, if the intensity or duration of the anxiety symptoms is substantially in excess of anxiety
symptoms that are characteristic of the substance-specific intoxication or withdrawal syndrome,
then substance-induced anxiety disorder is the appropriate diagnosis, applying the appropriate
category corresponding to the substance involved.
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

242 - 6E64 Secondary obsessive compulsive or relate
6E64 Secondary obsessive-compulsive or related syndrome
665
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
anxiety syndromes include:
• diseases of the nervous system (e.g. encephalitis, seizures);
• diseases of the circulatory system (e.g. cardiac arrhythmia, congestive heart failure,
hyperkinetic heart syndrome, mitral valve prolapse, pulmonary thromboembolis);
• diseases of the ear or mastoid process (e.g. acute vestibular syndrome);
• diseases of the respiratory system (e.g. asthma, chronic obstructive pulmonary disease);
• endocrine, nutritional or metabolic diseases (e.g. hyperadrenalism, hypercalcaemia,
hypermagnesaemia, hyperthyroidism, hypoglycaemia, hypoparathyroidism);
• neoplasms (e.g. malignant phaeochromocytoma of adrenal gland, neoplasms of brain
or meninges).
Secondary obsessive-compulsive or related syndrome
Essential (required) features
• The presence of prominent symptoms that are characteristic of obsessive-compulsive and
related disorders, such as obsessions, compulsions, skin picking, hair pulling or other
body-focused repetitive behaviours, is required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition, based on evidence from history, physical examination or laboratory findings.
This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of the symptoms (e.g. onset, remission, response to treatment of the etiological
medical condition) is consistent with causation by the medical condition.
• The symptoms are not better accounted for by another mental disorder (e.g. an obsessivecompulsive or related disorder) or the effects of a medication or substance, including
withdrawal effects.
• The symptoms do not meet the diagnostic requirements for secondary tics, classified in the
grouping of movement disorders in Chapter 8 on diseases of the nervous system.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
6E64
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with obsessive-compulsive and related disorders
Determining whether obsessive-compulsive or related symptoms are due to a medical condition
as opposed to manifestations of a primary mental disorder is often difficult because the clinical
presentations may be similar. Establishing the presence of a potentially explanatory medical
condition that can cause obsessive-compulsive or related symptoms and the temporal relationship
between the medical condition and the primary obsessive-compulsive or related symptoms is
critical in diagnosing secondary obsessive-compulsive or related syndrome. Secondary obsessivecompulsive or related syndrome is often characterized by clinical features that would be atypical
for obsessive-compulsive and related disorders, such as late age of onset, sudden appearance of
symptoms, or accompanying cognitive impairment or focal neurological signs.
Boundary with obsessive-compulsive and related symptoms caused by substances
or medications, including withdrawal effects
When establishing a diagnosis of secondary obsessive-compulsive or related syndrome, it is
important to rule out the possibility that a medication or substance is causing the obsessivecompulsive or related symptoms instead of – or in addition to – an underlying medical condition.
This involves first considering whether any of the medications being used to treat the medical
condition are known to cause obsessive-compulsive or related symptoms at the dose and duration
at which it has been administered. Second, a temporal relationship between the medication use
and the onset of the obsessive-compulsive or related symptoms should be established (i.e. the
obsessive-compulsive or related symptoms began after administration of the medication and/
or remitted once the medication was discontinued). The same reasoning applies to individuals
with a medical condition and obsessive-compulsive or related symptoms who are also using
a psychoactive substance known to cause obsessive-compulsive or related symptoms in the
context of either intoxication or withdrawal (e.g. cocaine-induced hair pulling, obsessions or
compulsions due to amfetamine intoxication). In such cases, a diagnosis of a substance-induced
obsessive-compulsive or related disorder should be assigned, applying the appropriate category
corresponding to the substance involved.
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
obsessive-compulsive or related syndromes include:
• diseases of the nervous system (e.g. epilepsy, Huntington disease, myoclonic disorders,
Parkinson disease, paediatric autoimmune neuropsychiatric disorders associated
with streptococcal infections (PANDAS), secondary chorea – including chorea due to
neuroacanthocytosis and McLeod syndrome, stroke);
• certain infectious or parasitic diseases (e.g. rheumatic chorea (Sydenham chorea));
• endocrine, nutritional or metabolic diseases (e.g. iron overload diseases such as
pantothenate-kinase-associated neurodegeneration);
• injury, poisoning or certain other consequences of external causes (e.g. brain injury);
• neoplasms (e.g. neoplasms of brain or meninges).
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

243 - 6E65 Secondary dissociative syndrome
6E65 Secondary dissociative syndrome
667
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Secondary dissociative syndrome
Essential (required) features
• The presence of prominent dissociative symptoms (e.g. depersonalization, derealization,
dissociative amnesia, a marked alteration in the individual’s normal sense of personal
identity) is required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition, based on evidence from the history, physical examination or laboratory findings.
This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the observed symptoms.
• The course of dissociative symptoms (e.g. onset, remission, response of the dissociative
symptoms to treatment of the etiological medical condition) is consistent with causation
by the medical condition.
• The symptoms are not better accounted for by delirium, dementia, another mental disorder
(e.g. dissociative disorders, disorders specifically associated with stress, schizophrenia and
other primary psychotic disorders) or the effects of a medication or substance, including
withdrawal effects.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with dissociative disorders
Determining whether dissociative symptoms are due to a medical condition as opposed to
manifestations of a primary mental disorder is often difficult because the clinical presentations
may be similar. Establishing the presence of a potentially explanatory medical condition that can
cause dissociative symptoms and the temporal relationship between the medical condition and
the dissociative symptoms is critical in diagnosing secondary dissociative syndrome.
Boundary with dissociative symptoms caused by substances or medications,
including withdrawal effects
When establishing a diagnosis of secondary dissociative syndrome, it is important to rule out the
possibility that a medication or substance is causing the dissociative symptoms instead of – or in
addition to – an underlying medical condition. This involves first considering whether any of the
medications being used to treat the medical condition are known to cause dissociative symptoms
at the dose and duration at which it has been administered. Second, a temporal relationship
between the medication use and the onset of the dissociative symptoms should be established
(i.e. the dissociative symptoms began after administration of the medication and/or remitted
once the medication was discontinued). The same reasoning applies to individuals with a medical
condition and dissociative symptoms who are also using a psychoactive substance known to
cause dissociative symptoms, in the context of either intoxication or withdrawal (e.g. amnesia
due to ketamine or phencyclidine intoxication, depersonalization due to dextromethorphan
intoxication).
6E65
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

244 - 6E66 Secondary impulse control syndrome
6E66 Secondary impulse control syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with dissociative symptoms that are precipitated by the stress of being
diagnosed with a medical condition
The stress of a medical diagnosis can precipitate dissociative symptoms (e.g. depersonalization,
derealization). Depending on the nature of the medical condition (e.g. a life-threatening type
of cancer, a potentially fatal infection) or its onset (e.g. a heart attack, a stroke, a severe injury),
being diagnosed and/or having to cope with a severe medical condition can be experienced as
a traumatic event, which may trigger dissociative symptoms. In the absence of evidence of a
physiological link between the medical condition and the dissociative symptoms, a diagnosis of
secondary dissociative syndrome is not warranted. Instead, the appropriate mental disorder can
be diagnosed (e.g. adjustment disorder, depersonalization-derealization disorder).
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
dissociative syndromes include:
• diseases of the nervous system (e.g. encephalitis, migraine, seizures, stroke);
• endocrine, nutritional or metabolic diseases (e.g. hyperglycaemia);
• injury, poisoning or certain other consequences of external causes (e.g. intracranial injury);
• neoplasms (e.g. neoplasms of brain).
Secondary impulse control syndrome
Essential (required) features
• The presence of prominent symptoms that are characteristic of impulse control disorders
or disorders due to addictive behaviours (e.g. stealing, fire setting, aggressive outbursts,
compulsive sexual behaviour, excessive gambling) is required for diagnosis.
• The symptoms are judged to be the direct pathophysiological consequence of a medical
condition, based on evidence from history, physical examination or laboratory findings.
This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of the symptoms (e.g. onset, remission, response to treatment of the etiological
medical condition) is consistent with causation by the medical condition.
• The symptoms are not better accounted for by delirium, dementia, another mental
disorder (e.g. an impulse control disorder or a disorder due to addictive behaviours), or
the effects of a medication or substance, including withdrawal effects.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
6E66
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
669
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with primary impulse control disorder or disorders due to addictive
behaviours
Determining whether disturbances of impulse control are due to medical conditions classified
elsewhere or are manifestations of an impulse control disorder or a disorder due to addictive
behaviours is often difficult because the clinical presentations may be similar. Establishing the
presence of a potentially explanatory medical condition that can cause disturbances of impulse
control and the temporal relationship between the medical condition and the disturbances of
impulse control is critical in diagnosing secondary impulse control syndrome. Compared to
impulse control disorders or disorders due to addictive behaviours, secondary impulse control
syndrome is more likely to be associated with atypical clinical features, such as a later age of onset
or the presence of disturbances of impulse control in individuals who generally exhibit low levels
of disinhibition or negative emotionality.
Boundary with delirium and dementia
Disturbances of impulse control or addictive behaviour can occur in the context of delirium or
dementia. Secondary impulse control syndrome is characterized by disturbances of impulse control
or addictive behaviours (e.g. aggressive outbursts, compulsive sexual behaviour) occurring in the
absence of severe cognitive impairment. In contrast, delirium is characterized by fluctuating levels
of consciousness and autonomic disturbances, while dementia is characterized by severe memory
impairment as well as impairments in other domains of cognitive functioning. Disturbances of
impulse control or addictive behaviour in the context of dementia may be recorded using one of
the behavioural or psychological disturbances in dementia specifiers (e.g. agitation or aggression
in dementia, disinhibition in dementia), if applicable. If the symptoms are judged to be due to the
same medical condition as is causing the dementia, an additional diagnosis of secondary impulse
control syndrome is not warranted.
Boundary with secondary personality change
Disturbances of impulse control or addictive behaviour can occur as part of secondary personality
change. If the disturbances of impulse control are accompanied by other features of personality
disturbance that are also judged to be due to a medical condition classified elsewhere, a diagnosis
of secondary personality change should be assigned instead.
Boundary with disturbances of impulse control or addictive behaviour caused by
substances or medications, including withdrawal effects
When establishing a diagnosis of secondary impulse control syndrome, it is important to rule
out the possibility that a medication or substance is causing the symptoms instead of – or in
addition to – an underlying medical condition. This involves first considering whether any of
the medications being used to treat the medical condition are known to cause disturbances of
impulse control or addictive behaviour at the dose and duration at which it has been administered
(e.g. dopamine agonists such as pramipexole for Parkinson disease or restless legs syndrome).
Second, a temporal relationship between the medication use and the onset of the symptoms
should be established (i.e. the symptoms began after administration of the medication and/or
remitted once the medication was discontinued). The same reasoning applies to individuals
with a medical condition and disturbances of impulse control who are also using a psychoactive
substance known to cause disturbances of impulse control or addictive behaviour, in the
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

245 - 6E67 Secondary neurocognitive syndrome
6E67 Secondary neurocognitive syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
context of either intoxication or withdrawal (e.g. compulsive sexual behaviour due to cocaine
intoxication, aggressive outburst due to methamfetamine intoxication). In such cases, substanceinduced impulse control disorder is the appropriate diagnosis, applying the appropriate category
corresponding to the substance involved.
Potentially explanatory medical conditions (examples)
Brain disorders and general medical conditions that have been shown to be capable of producing
impulse control syndromes include:
• diseases of the nervous system (e.g. encephalitis, seizures, stroke, Klüver–Bucy syndrome);
• developmental anomalies (e.g. male with double or multiple Y [xyy syndrome]);
• endocrine diseases;
• injury, poisoning or certain other consequences of external causes (e.g. intracranial injury);
• neoplasms (e.g. neoplasms of brain).
Secondary neurocognitive syndrome
Essential (required) features
• The presence of deficits in neurocognitive functioning that do not meet the diagnostic
requirements for delirium, mild neurocognitive disorder, amnestic disorder or dementia,
and do not have their onset during the developmental period, is required for diagnosis.
• The neurocognitive symptoms are judged to be the direct pathophysiological consequence
of a medical condition, based on evidence from the history, physical examination or
laboratory findings (as opposed to being a psychological reaction to having the medical
condition). This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the symptoms.
• The course of the deficits in neurocognitive functioning (e.g. onset, remission, response
to treatment of the etiological medical condition) is consistent with causation by the
medical condition.
• The symptoms are not judged to be better explained by disturbance of consciousness or
altered mental status (e.g. due to seizure, traumatic brain injury, stroke or the effects of
medication), a neurodevelopmental disorder, another mental disorder (e.g. schizophrenia
or another primary psychotic disorder, a mood disorder, post-traumatic stress disorder,
a dissociative disorder) or the effects of a medication or substance, including withdrawal
effects.
• The symptoms are of short duration (e.g. less than 1 month), and it is expected that the
neurocognitive symptoms will remit with treatment of the etiological medical condition.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
6E67
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
671
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with neurocognitive disorders
Delirium, mild neurocognitive disorder, amnestic disorder and dementia can all be caused by
medical conditions classified elsewhere. If the presentation meets the diagnostic requirements for
any of these neurocognitive disorders, that diagnosis should be assigned rather than secondary
neurocognitive syndrome. If the presence of a specific etiological medical condition has not been
established, a diagnosis of other specified neurocognitive disorder should be assigned.
Boundary with disorders of intellectual development
Presentations that meet the diagnostic requirements for disorder of intellectual development
and are judged to be the direct pathophysiological consequence of a medical condition are
not diagnosed as secondary neurocognitive syndrome because, by convention, disorders
of intellectual development are diagnosed regardless of etiology. In these cases, disorder of
intellectual development and the underlying medical condition should be diagnosed, and a
diagnosis of secondary neurocognitive syndrome is not assigned.
Boundary with secondary neurodevelopmental syndrome
Secondary neurodevelopmental syndrome may also be characterized by cognitive impairment
that is judged to be due to a medical condition. If the cognitive impairment has its onset during
the developmental period, the appropriate diagnosis is secondary neurodevelopmental syndrome
rather than secondary neurocognitive syndrome.
Boundary with other mental disorders that may be associated with cognitive
impairment
Deficits in cognitive functioning may be a presenting or associated feature of a variety of mental
disorders (e.g. developmental speech or language disorders, developmental learning disorders,
schizophrenia or other primary psychotic disorders, mood disorders). Secondary neurocognitive
syndrome should be diagnosed only if a medical condition has been identified that is judged to
be the direct physiological cause of the neurocognitive impairment.
Boundary with deficits in cognitive functioning caused by substances or
medications, including withdrawal effects
When establishing a diagnosis of secondary neurocognitive syndrome, it is important to rule out
the possibility that a medication or substance is causing the deficits in neurocognitive functioning
instead of – or in addition to – an underlying medical condition. This involves first considering
whether any of the medications being used to treat the medical condition are known to cause
deficits in cognitive functioning at the dose and duration at which it has been administered.
Second, a temporal relationship between the medication use and the onset of the deficits in
neurocognitive functioning should be established (i.e. deficits in neurocognitive functioning
began after administration of the medication and/or remitted once the medication was
discontinued). The same reasoning applies to individuals with a medical condition who are using
a psychoactive substance known to cause deficits in neurocognitive functioning (e.g. memory
loss due to sedative intoxication, disturbed attention/concentration and orientation due to
alcohol intoxication). In such cases, delirium, amnestic disorder or dementia due to psychoactive
substances (including medications) or mild neurocognitive disorder is the appropriate diagnosis,
applying the appropriate category corresponding to the substance involved.
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

246 - 6E68 Secondary personality change
6E68 Secondary personality change
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Potentially explanatory medical conditions
Brain disorders and general medical conditions that have been shown to be capable of producing
neurocognitive syndromes include:
• diseases of the nervous system (e.g. adrenoleukodystrophy, cerebral arteritis, seizures);
• certain infectious or parasitic diseases (e.g. cryptococcosis, Lyme borreliosis, neurosyphilis);
• diseases of the blood or blood-forming organs (e.g. sickle cell disorders);
• diseases of the digestive system (e.g. hepatic failure, intestinal malabsorption);
• diseases of the genitourinary system (e.g. renal failure);
• diseases of the immune system (e.g. eosinophilia, systemic lupus erythematosus);
• endocrine, nutritional or metabolic diseases (e.g. hypercalcaemia, hypo- or hyperglycaemia,
hypothyroidism);
• neoplasms (e.g. neoplasms of brain).
Secondary personality change
Essential (required) features
• The presence of personality disturbance (e.g. marked apathy, indifference, suspiciousness,
paranoid ideation, disinhibition) that represents a change from the individual’s previous
characteristic personality pattern is required for diagnosis.
• The personality change is judged to be the direct pathophysiological consequence of a
medical condition, based on evidence from the history, physical examination or laboratory
findings. This judgement depends on establishing the following.
• The medical condition is known to be capable of producing the observed symptoms.
• The course of the personality change (e.g. onset, remission, response of the personality
disturbance to treatment of the etiological medical condition is consistent with causation
by the medical condition).
• The symptoms are not better accounted for by delirium, dementia, another mental
disorder (e.g. personality disorder, impulse control disorders, secondary impulse control
or addictive behaviour syndrome) or the effects of a medication or substance, including
withdrawal effects.
• The symptoms are sufficiently severe to be a specific focus of clinical attention.
6E68
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
673
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with personality disorder and personality difficulty
Establishing the presence of a potentially explanatory medical condition that can cause personality
change and the temporal relationship between the medical condition and the personality change
is critical in diagnosing secondary personality change. Personality is relatively stable over time,
and personality disorder and personality difficulty are usually evident by early adulthood. In
contrast, secondary personality change has its onset following or coincident with the onset of a
medical condition that is judged to be its direct pathophysiological cause, and is characterized
by the emergence of personality traits that represent a change from the individual’s previous
characteristic personality pattern (e.g. marked apathy, indifference, suspiciousness, paranoid
ideation, disinhibition).
Boundary with dementia
Personality change can occur in the context of dementia, which is characterized by a decline from
a previous level of cognitive functioning with impairment in two or more cognitive domains (e.g.
memory, executive functions, attention, language, social cognition and judgement, psychomotor
speed, visuoperceptual or visuospatial abilities). In secondary personality change, the emergence of
personality traits that represent a change from the individual’s previous characteristic personality
pattern is not accompanied by marked cognitive impairment. The emergence of problematic
personality features in the context of dementia may be recorded using one of the behavioural or
psychological disturbances in dementia specifiers (e.g. apathy in dementia, agitation or aggression
in dementia, disinhibition in dementia), if applicable. If the personality changes are judged to
be due to the same medical condition as is causing the dementia, an additional diagnosis of
secondary personality change is not warranted.
Boundary with personality change caused by substances or medications, including
withdrawal effects
When establishing a diagnosis of secondary personality change, it is also important to rule out
the possibility that a substance or medication is causing the personality disturbance instead of
– or in addition to – an underlying medical condition. This involves first considering whether
any of the medications being used to treat the medical condition are known to cause personality
disturbance at the dose and duration at which it has been administered (e.g. apathy due to chronic
cannabis use, paranoid ideation due to chronic stimulant use). Second, a temporal relationship
between the medication use and the onset of the personality disturbance should be established
(i.e. the personality change began after administration of the medication and/or remitted once the
medication was discontinued). If the intensity or duration of the personality change is substantially
in excess of symptoms that are characteristic of the substance-specific intoxication or withdrawal
syndrome, then other disorder due to use of substances is the appropriate diagnosis, applying the
appropriate category corresponding to the substance involved.
Boundary with secondary impulse control or addictive behaviour syndrome
Personality changes may include symptoms of disordered impulse control or addictive behaviours.
If the personality changes judged to be the direct pathophysiological consequence of a medical
condition are restricted to increased impulsivity or addictive behaviours, then secondary
impulse control or addictive behaviour syndrome is the appropriate diagnosis rather secondary
personality change.
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere

247 - 6E69 Secondary catatonia syndrome
6E69 Secondary catatonia syndrome

07 - Relationship problems and maltreatment

01 - Maltreatment as a cause of injury or death
Maltreatment as a cause of injury or death
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Maltreatment as a cause of injury or death
Categories for maltreatment from Chapter 23 on external causes of morbidity or mortality
are used when the purpose is to document the cause of an injury being treated or the cause of
death. These categories are used along with a classification of the associated physical injury (e.g.
fracture of nasal bones, burns of external body surface). Available maltreatment categories in
Chapter 23 include:
Physical maltreatment
Sexual maltreatment
Psychological maltreatment
Other specified maltreatment
Maltreatment, unspecified
Unintentional neglect
Assault by neglect
Neglect with undetermined intent.
The associated injury from Chapter 22 on injury, poisoning or certain other consequences of
external causes is postcoordinated with the type of maltreatment presumed to have caused it.
Mental, behavioural and neurodevelopmental disorders such as post-traumatic stress disorder
and recurrent depressive disorder can clearly be the result of or be exacerbated by maltreatment,
but they are not typically considered immediate causes of the types of injuries classified in
Chapter 22. However, mental disorders are provided as postcoordination options for PJ22
Psychological maltreatment. For other maltreatment categories in Chapter 23, any applicable
mental, behavioural and neurodevelopmental disorder diagnosis should be assigned separately.
Additional dimensions of the maltreatment as a cause of injury can also be specified via
postcoordination. These include activity when injured (e.g. paid work, educational activity),
place of occurrence (e.g. home, school, education area), the perpetrator–victim relationship (e.g.
spouse or partner, parent, stranger) and the gender of the perpetrator.
As an illustration, below is a fully postcoordinated example of a Chapter 23 maltreatment code:
• PJ20 Physical maltreatment
• Associated with: NA02.3 Fracture of skull or facial bones
• Activity when injured: XE9ME Unpaid cleaning, cooking or maintenance at own place
of residence
• Place of occurrence: XE266 Home
• Perpetrator–victim relationship: XE454 Spouse or partner
• Gender of perpetrator, male: XE5YG
• Context of assault and maltreatment: XE0UM Altercation
The full postcoordinated code is: PJ20&XE9ME&XE266&XE454&XE5YG&XE0UM/NA02.3.
(See discussion of ICD-11 diagnostic coding, p. 30, in the introductory section on using the
CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders.)
PJ20
PJ21
PJ22
PJ2Y
PJ2Z
PJ5B
PF1B
PH7B
Relationship problems and maltreatment

02 - Relationship problems and maltreatment as fac
Relationship problems and maltreatment as factors influencing health status or health services
709
Relationship problems and maltreatment
Relationship problems and maltreatment as factors
influencing health status or contact with health services
Categories for relationship problems and maltreatment from Chapter 24 on factors influencing
health status or contact with health services are used when the purpose is to record one of three
types of clinically significant relationship phenomena. These are:
• to document a pattern of clinically significant relationship conflict with an intimate
partner, parent or other caregiver;
• to document a history over the individual’s lifetime of maltreatment independent of
a specific injury or other harm, which may refer to ongoing maltreatment or to past
episodes – such as a history of child abuse – that are relevant to the individual’s health
status or encounters with the health system; or
• to document a possible episode of maltreatment that is currently under clinical investigation.
QE51.0
Relationship problems and maltreatment
P
Relationship distress with spouse or partner
Relationship distress with spouse or partner is defined as substantial and
sustained dissatisfaction with a spouse or intimate partner associated with
significant disturbance in functioning. This diagnosis can be assigned to one or
both parties in a dyad, depending on the context of the evaluation or treatment.
Caregiver–child relationship problem
Caregiver–child relationship problem is defined as substantial and sustained
dissatisfaction within a caregiver–child relationship, including a parental
relationship, associated with significant disturbance in functioning. This
diagnosis can be assigned to one or both parties in a dyad, depending on the
context of the evaluation or treatment.
QE52.0
Available categories for history of maltreatment in Chapter 24 are:
History of spouse or partner violence
QE51.10
History of spouse or partner violence, physical
QE51.11
History of spouse or partner violence, psychological
QE51.12
History of spouse or partner violence, sexual
QE51.13
History of spouse or partner violence, neglect.
These diagnoses can be used to indicate ongoing or past episodes of maltreatment
by a spouse or partner when the focus of the evaluation is not related to a specific
injury or death. If the history of maltreatment is not related to a spouse or partner
relationship, categories from QE82 Personal history of maltreatment should be
used instead.
QE51.1
Available categories for intimate partner or caregiver–child
relationship distress or conflict in Chapter 24 are:
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Available categories for examination or observation for suspected
maltreatment in Chapter 24 are:
Relationship problems and maltreatment | Personal history of maltreatment
Personal history of maltreatment
QE82.0
Personal history of physical abuse
QE82.1
Personal history of sexual abuse
QE82.2
Personal history of psychological abuse
QE82.3
Personal history of neglect
QE82.Y
Other specified personal history of maltreatment
QE82.Z
Personal history of maltreatment, unspecified.
These diagnoses can be used to indicate ongoing or past episodes of maltreatment
by someone other than a spouse or partner (e.g. a parent, another relative, a
stranger), when the focus of the evaluation is not related to a specific injury or
death. If the history of maltreatment is related to a spouse or partner relationship,
categories from QE51.1 History of spouse or partner violence should be used
instead. The time in life (e.g. child under 5 years, adolescent, late geriatric) can be
indicated using postcoordinated extension codes.
QE82
Examination or observation for suspected maltreatment
QA04.50
Examination or observation for suspected physical
maltreatment
QA04.51
Examination or observation for suspected sexual
maltreatment
QA04.52
Examination or observation for suspected psychological
maltreatment
QA04.53
Examination or observation for suspected neglect or
abandonment
QA04.5Y
Other specified examination or observation for suspected
maltreatment
QA04.5Z
Examination or observation for suspected maltreatment,
unspecified.
QA04.5
If maltreatment is confirmed based on the examination or observation, the diagnosis should
generally be changed to one of the maltreatment categories in Chapter 24, if the evaluation is in
relation to a specific injury, or otherwise to the applicable history or spouse or partner violence or
personal history of maltreatment category in Chapter 24.
In some circumstances, categories from Chapter 23 and Chapter 24 can be used together – for
example, when there is an established history of maltreatment, and an injury resulting from that
maltreatment is the focus of a current episode of care. However, examination or observation
codes in Chapter 24 would typically not be assigned together with maltreatment categories from
Chapter 23 explaining the cause of a specific injury.

03 - Relationship distress and current or past mal
Relationship distress and current or past maltreatment by spouse or partner
711
Relationship problems and maltreatment
Relationship problems and maltreatment | Personal history of maltreatment
As an illustration, below is a postcoordinated example of a Chapter 23 maltreatment code:
•
QE82.1 Personal history of sexual abuse
•
Time in life: XT7Q Early adolescence.
The postcoordinated code is: QE82.1&XT7Q.
(See discussion of ICD-11 diagnostic coding, p. 30, in the introductory section on using the
CDDR for ICD-11 mental, behavioural and neurodevelopmental disorders.)
CDDR for common forms of relationship problems
and maltreatment
Because of their importance and prevalence, CDDR have been developed for two sets
of phenomena:
• relationship distress and current or past maltreatment by spouse or partner;
• problems in relationship between child and current or former caregiver, and current or
past child maltreatment.
These are among the most clinically important and impactful forms of relationship problems and
maltreatment. The CDDR for these two groupings should be applied as appropriate in the context
of the ICD-11 coding options for relationship problems and maltreatment. For example, physical
abuse by an intimate partner could be classified as PJ20 Physical maltreatment from Chapter 23
or QE51.1 History of spouse or partner violence from Chapter 24, depending on the purpose of
the assessment and nature of the situation.
Relationship distress and current or past maltreatment by
spouse or partner
This section provides CDDR for the following categories:
• to document the cause of an injury being treated or the cause of death:
PJ20 Physical maltreatment, spouse or partner
PJ21 Sexual maltreatment, spouse or partner
PJ22 Psychological maltreatment, spouse of partner
PF1B Assault by neglect
• to document a pattern of either a clinically significant relationship conflict with a spouse
or intimate partner, or a history of intimate partner maltreatment – including ongoing or
past episodes – as factors that are relevant to the individual’s health status and encounters
with health services rather than in relationship to a specific injury or death:

04 - QE51.0 Relationship distress with spouse or p
QE51.0 Relationship distress with spouse or partner
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
QE51.0 Relationship distress with spouse or partner
QE51.1 History of spouse or partner violence
QE51.10 History of spouse or partner violence, physical
QE51.12 History of spouse or partner violence, sexual
QE51.11 History of spouse or partner violence, psychological
QE51.13 History of spouse or partner violence, neglect.
Relationship distress with spouse or partner and different forms of intimate partner maltreatment
can co-occur. As many of the categories in this section may be assigned together as necessary to
describe the relevant clinical phenomena.
General cultural considerations for relationship distress and maltreatment by
spouse or partner
• Presentations of relationship distress vary, depending on cultural constraints on their
expression. In some cultures, women may be more attentive to relationship problems and
therefore more likely report relationship distress.
• The prevalence of the different forms of spouse or partner maltreatment (e.g. physical,
sexual, psychological) vary widely by country, based on the social acceptance, detection
and consequences of abusive behaviours.
General sex- and/or gender-related features for relationship distress and
maltreatment by spouse or partner
• Although men and women are both affected by relationship distress, women’s health may
be more influenced by relationship distress, whereas men’s health may be more influenced
by relationship status (i.e. being in an intimate partner relationship or not).
• Gender differences are country- and culture-specific. Overall, women are at much higher
risk of victimization by maltreatment by their spouses or intimate partners.
Relationship distress with spouse or partner
Essential (required) features
• Substantial and sustained dissatisfaction with the intimate relationship (e.g. pervasive
unhappiness with the relationship, significant thoughts of divorce/separation) is required
for diagnosis.
• The dissatisfaction is associated with disturbance in at least one major area of functioning
such as:
• behaviour (e.g. persistent and intense conflicts, pervasive withdrawal or neglect, lack of
positive behaviours);
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner
QE51.0
713
Relationship problems and maltreatment
• cognition (e.g. pervasive negative attributions of partner’s intent);
• emotion (e.g. persistent and intense anger, sadness or apathy);
• physical health (e.g. pain and other physical symptoms not fully explained by a medical
condition);
• interpersonal interaction (e.g. social isolation, decreased involvement in social activities);
• major life role activities (e.g. work, school, caregiving).
Note: this category is assigned to the individual being evaluated. In situations in which a couple
is being evaluated, it may be assigned to both parties if applicable.
Additional clinical features
• Relationship distress with spouse or partner is associated with increased risk of various
mental disorders (e.g. depressive disorders, anxiety and fear-related disorders, disorders
due to substance use), and risk of exacerbation of existing medical conditions.
Boundary with normality (threshold)
• Occasional relationship dissatisfaction and disagreements occur in most relationships.
Relationship distress with a spouse or partner should only be assigned when relationship
dissatisfaction or conflict is a pervasive pattern affecting the individual’s functioning in at
least one major area.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with spouse or partner maltreatment (physical, psychological, sexual,
or neglect)
Relationship distress with spouse or partner is not considered a form of maltreatment. However,
if all diagnostic requirements are met for both relationship distress with spouse or partner and a
maltreatment category, both may be assigned.
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner

05 - PJ20 Physical maltreatment, spouse or partner
PJ20 Physical maltreatment, spouse or partner, or QE51.10 history of spouse or partner ...
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Physical maltreatment, spouse or partner, or history of spouse or
partner violence, physical
Essential (required) features
• At least one non-accidental act of physical force (e.g. pushing or shoving, scratching,
slapping, throwing something that could cause injury, punching, biting) is required for
diagnosis.
• The act causes (or exacerbates) at least one of the following:
• any physical injury;
• significant fear;
• reasonable potential for significant physical injury.
• The act was not for physical protection of the individual (e.g. to ward off a partner’s
punches) or partner (e.g. to prevent a partner from attempting suicide).
Note: these categories are assigned to the victim, not the perpetrator. In cases of mutual violence
in which the couple is being evaluated, they may be assigned to both parties if applicable.
If PJ20 Physical maltreatment is diagnosed, the perpetrator should be specified as a spouse or
partner using the extension code XE454 (PJ20&XE454). On the ICD-11 platform, the option to
specify the perpetrator–victim relationship appears in the context of the assault field.
Additional clinical features
• Intimate partner physical abuse is, by definition, associated with an increased risk of
physical injury and need for medical attention.
• Intimate partner physical abuse is associated with an increased risk of poor physical health
and the development of a chronic disease.
• Intimate partner physical abuse is associated with higher rates of depressive disorders,
post-traumatic stress disorder and disorders due to substance use, as well as suicidality.
• A pattern of recurrent acts, or the intent to assert control or power, are not required features
for assigning a diagnosis of intimate partner physical abuse. The diagnosis only requires at
least one act of violence that causes or exacerbates at least one negative impact.
• Most children (i.e. approximately 75%) living in households with clinically significant
intimate partner physical abuse witness it. Exposure to parental or caregiver intimate
partner violence places children at significantly greater risk of a range of mental disorders,
negative affect/distress and negative cognitions, as well as social and academic difficulties.
PJ20 /
QE51.10
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner
715
Relationship problems and maltreatment
Boundary with normality (threshold)
• Acts of physical aggression (e.g. grabbing a partner’s arm) that do not cause injury or
significant fear are relatively common in intimate relationships. In contrast, the acts of
physical violence and associated impacts characteristic of intimate partner physical abuse
are not part of healthy functioning relationships.
Course features
• Intimate partner physical abuse may lessen and remit over time. However, for many
affected relationships, intimate partner physical abuse reoccurs and sometimes increases
in frequency or severity.
• The risk of intimate partner physical abuse increases in the context of external stressors
(e.g. job loss) or when the victim is disabled.
Developmental presentations
• In general, adolescents and young adults are at greater risk of being victims of intimate
partner physical abuse because the rate of physically violent acts against intimate partners
among perpetrators tends to decrease across the lifespan.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with relationship distress with spouse or partner
Intimate partner physical abuse may be, but is not always, associated with relationship distress
with spouse or partner. If all diagnostic requirements are met for both relationship distress
with spouse or partner and maltreatment or history of spouse or partner violence, both may
be assigned.
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner

06 - PJ21 Sexual maltreatment, spouse or partner,
PJ21 Sexual maltreatment, spouse or partner, or QE51.12 history of spouse or partner ...
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Sexual maltreatment, spouse or partner, or history of spouse or
partner violence, sexual
Essential (required) features
• At least one of the following acts is required for diagnosis:
• the use of physical force to compel participation in a sex act against the partner’s will, or
when the partner is incapable of consent (whether or not the act is completed);
• the use of physical or psychological aggression to coerce the partner to participate in a
sex act.
• The act is against the expressed wishes of the partner.
• The act causes significant distress to the partner.
Note: these categories are assigned to the victim, not the perpetrator.
If PJ21 Sexual maltreatment is diagnosed, the perpetrator should be specified as a spouse or
partner using the extension code XE454 (PJ21&XE454). On the ICD-11 platform, the option to
specify the perpetrator–victim relationship appears in the context of the assault field.
Additional clinical features
• Intimate partner sexual abuse is associated with an increased risk of physical injury and
need for medical attention.
• Intimate partner sexual abuse is associated with an increased risk of poor physical health
and of development of a chronic disease.
• Intimate partner sexual abuse is associated with increased risk of various mental disorders
(e.g. depressive disorders, anxiety and fear-related disorders, disorders due to substance
use), as well as suicidality.
Boundary with normality (threshold)
• Sexual violation and coercion are not part of healthy functioning relationships.
PJ21/
QE51.12
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner

07 - PJ22 Psychological maltreatment, spouse or pa
PJ22 Psychological maltreatment, spouse or partner, or QE51.11 History of spouse or partner ...
717
Relationship problems and maltreatment
Developmental presentations
• In general, adolescents and young adults are at greater risk of being victims of intimate
partner sexual abuse because the rate of sexually abusive acts among perpetrators tends to
decrease across the lifespan.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with relationship distress with spouse or partner
Intimate partner sexual abuse may be, but is not always, associated with relationship distress with
spouse or partner. If all diagnostic requirements are met for both relationship distress with spouse
or partner and maltreatment or history of spouse or partner violence, both may be assigned.
Psychological maltreatment, spouse or partner, or history of spouse
or partner violence, psychological
Essential (required) features
• Verbal or symbolic acts with the potential to cause psychological harm to the victim are
required for diagnosis, such as:
• berating, disparaging, degrading, humiliating the partner;
• interrogating the partner;
• restricting the partner’s ability to come and go freely;
• obstructing the partner’s access to assistance (e.g. police aid, legal help, protective
resources, medical resources, mental health resources);
• threatening the partner;
• harming, or threatening to harm, people/things that the partner cares about;
• restricting the partner’s access to or use of economic resources;
• isolating the partner from family, friends or social support resources;
• stalking the partner;
• trying to make people think that the partner is “crazy”, including for suggesting that they
are a victim of psychological maltreatment.
• The acts cause (or exacerbate) at least one of the following:
• significant fear;
• significant psychological distress;
• somatic symptoms that interfere with normal functioning;
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner
PJ22/
QE51.11
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• significant self-imposed restrictions in engaging in one or more major life activities (e.g.
work, education, religion, medical or mental services, contact with family members) to
avoid recurrence of the acts.
Note: these categories are assigned to the victim, not the perpetrator.
If PJ22 Psychological maltreatment is diagnosed, the perpetrator should be specified as a spouse
or partner using the extension code XE454 (PJ22&XE454). On the ICD-11 platform, the option
to specify the perpetrator–victim relationship appears in the context of the assault field.
Additional clinical features
• Intimate partner psychological abuse typically represents a pattern of behaviours. However,
it may be diagnosed based on a single episode if it is sufficiently impactful (e.g. harming a
pet to punish the partner).
• Intimate partner psychological abuse at a clinically significant level is associated with
increased risk of seeking medical attention, as well as an increased risk of poor health and
of development of a chronic disease.
• Intimate partner psychological abuse is associated with higher rates of depressive disorders,
post-traumatic stress disorder and disorders due to substance use, as well as suicidality.
Boundary with normality (threshold)
• Acts of psychological aggression (e.g. disparaging one’s partner) that do not cause
significant distress are relatively common in intimate relationships. In contrast, the
verbal and symbolic acts and their associated impacts that constitute intimate partner
psychological abuse are not characteristic of healthy functioning relationships.
Course features
• Intimate partner psychological abuse commonly emerges in adolescence and early
adulthood, but is prevalent across the lifespan.
• The risk of intimate partner psychological abuse increases in the context of external
stressors (e.g. job loss).
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner

08 - PF1B Assault by neglect or QE51.13 History of
PF1B Assault by neglect or QE51.13 History of spouse or partner violence, neglect
719
Relationship problems and maltreatment
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with relationship distress with spouse or partner
Intimate partner psychological abuse may be, but is not always, associated with relationship
distress with spouse or partner. If all diagnostic requirements are met for both relationship
distress with spouse or partner and maltreatment or history of spouse or partner violence, both
may be assigned.
Assault by neglect or history of spouse or partner violence,
neglect
Essential (required) features
• At least one egregious act or omission by an adult’s caregiver that deprives an intimate
partner who is incapable of self-care of needed or adequate food, shelter, hygiene or
necessary services is required for diagnosis. Examples of self-care incapacity include
physical, psychological, intellectual and cultural (e.g. inability to manage activities of
rudimentary daily living due to living in a foreign culture) limitations.
• The act or omission causes significant physical injury or other significant negative
consequences to health (e.g. development of an illness directly linked to the neglect,
malnutrition) or reasonable potential for significant injury or negative consequences
to health.
Note: this category is assigned to the victim, not the perpetrator.
If PF1B Assault by neglect is diagnosed, the perpetrator should be specified as a spouse or partner
using the extension code XE454 (PF1B&XE454). On the ICD-11 platform, the option to specify
the perpetrator–victim relationship appears in the context of the assault field. Depending on the
specific situation, PB5B Unintentional neglect or PH7B Neglect with undetermined intent may
be diagnosed rather than PF1B Assault by neglect.
Additional clinical features
• Neglect at a clinically significant level is associated with increased risk of various mental
disorders (e.g. depressive disorders, anxiety and fear-related disorders, post-traumatic
stress disorder), suicidality and various medical conditions (e.g. bed sores, malnutrition).
PF1B /
QE51.13
Relationship problems and maltreatment | Relationship distress and current or past maltreatment by spouse or partner

09 - Problems in relationship between child and ca
Problems in relationship between child and caregiver and current or past child maltreatment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• Small lapses in caregiving to partners who are incapable of self-care are common, and
a diagnosis of history of spouse or partner violence, neglect, should not be assigned on
this basis. In contrast, egregious acts or omissions that cause significant physical injury or
reasonable potential for such injury much less common and, if all diagnostic requirements
are met, warrant the diagnosis.
Problems in relationship between child and current or
former caregiver and current or past child maltreatment
This section provides CDDR for the following categories:
• to document the cause of an injury being treated or the cause of death:
PJ20 Physical maltreatment of a child
PJ21 Sexual maltreatment of a child
PJ22 Psychological maltreatment of a child
PF1B Assault by neglect
• to document a pattern of either a clinically significant relationship conflict in the relationship
of a child with a current or former caregiver, or a history of child maltreatment – including
ongoing or past episodes – as factors that are relevant to the individual’s health status and
encounters with health services rather than in relationship to a specific injury or death:
QE52.0 Caregiver–child relationship problem
QE82.0 Personal history of physical abuse as a child
QE82.1 Personal history of sexual abuse as a child
QE82.2 Personal history of psychological abuse as a child
QE82.3 Personal history of neglect as a child.
Caregiver–child relationship problem and different forms of child maltreatment may co-occur.
As many of the categories in this section may be assigned together as necessary to describe the
relevant clinical phenomena.
Problems in relationship between child and current former caregiver and current or past child maltreatment

10 - QE52.0 Caregiver child relationship problem
QE52.0 Caregiver-child relationship problem
721
Relationship problems and maltreatment
Caregiver–child relationship problem
Essential (required) features
• Substantial and sustained dissatisfaction with the caregiver–child relationship (including
adolescents) is required for diagnosis; this may be manifested in:
• a pervasive sense of unhappiness with the relationship;
• for the child, repeated running away, persistent thoughts of running away or fantasies of
having another caregiver;
• for the caregiver, wishing the child were totally different or had not been born, or thoughts
of relinquishing care of the child;
• the child allying themselves strongly with one parent and rejecting a relationship with the
other parent, without evidence of maltreatment by the rejected parent – this primarily
occurs in the context of a high-conflict relationship between two parents, including
separation or divorce.
• The dissatisfaction is associated with disturbance in at least one major area of functioning,
such as the following:
• behaviour (e.g. persistent and intense conflicts, pervasive withdrawal or neglect; lack of
positive behaviours; failure to socialize child through nonexistent or poorly enforced
limits; poor monitoring of the child’s activities; overinvolvement in child’s activities;
child concealment of activities; child’s persistent rejection, denigration and criticism of
the caregiver);
• cognition (e.g. pervasive negative attributions of caregiver or child intent);
• emotion (e.g. persistent and intense anger, contempt, sadness or apathy);
• physical health (i.e. exacerbation of medical or psychological symptoms or significant
interference with provision of medical or psychological care);
• interpersonal interaction (e.g. social isolation, decreased involvement in social activities);
• major life role activities (e.g. work, school, caregiving).
Note: behaviours associated with each area will vary according to the developmental stage of
the child or adolescent, as well as the cultural context. This category should only be considered
as applicable within a child or adolescent’s primary caregiving relationships, which may include
relationships with parents, grandparents or other significant long-term caregivers. This category
may be assigned to either the child or the caregiver, depending on who is being evaluated.
In situations in which a caregiver–child dyad is being evaluated, substantial and sustained
relationship dissatisfaction, if present, is commonly – although not always – experienced by both
parties. The diagnosis may be assigned to both parties if applicable.
Additional clinical features
• Problems in caregiver–child relationships are associated with the development of
oppositional defiant disorder and conduct-dissocial disorder.
QE52.0
Problems in relationship between child and current former caregiver and current or past child maltreatment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Boundary with normality (threshold)
• Temporary fluctuations in parenting behaviours due to stress or illness are common. For
example, a parent undergoing serious medical treatment may be unable temporarily to
meet a child’s needs appropriately. Similarly, more focused conflicts with caregivers are
common among adolescents. Caregiver–child relationship problem should only be
assigned if the relationship distress is substantial and sustained, and affects functioning.
Course features
• Caregiver–child relationship problem has a variable course. In some cases, relationship
distress has a chronic course; in other cases, it may show substantial improvement over time.
Developmental presentations
• Young children are more likely to present with attachment problems (insecure or
disorganized patterns), difficulty separating from parents or caregivers, or physical
complaints than psychological symptoms. Psychological symptoms are more likely among
older children and adolescents.
• In infants or young children, distress may be exhibited by persistent withdrawal from the
caregiver, freezing behaviours or heightened reactivity around the caregiver. Significant
impact may be evidenced by a lack of appropriate developmental progression or even a loss
of skills in an infant or young child.
• For children or teens, distress may be exhibited by physical aggression, poor cooperation
or oppositional behaviour with the affected caregiver, or by refusal to interact with the
affected caregiver.
• Older caregivers, such as grandparents, may be more vulnerable to problems in their
relationships with high-energy children.
Sex- and/or gender-related features
• Although both the nature of the parental acts and their impact can vary by gender, boys
and girls are equally likely to experience a caregiver–child relationship problem.
Problems in relationship between child and current former caregiver and current or past child maltreatment

11 - PJ20 Physical maltreatment of child or QE82.0
PJ20 Physical maltreatment of child or QE82.0 Personal history of physical abuse as a child
723
Relationship problems and maltreatment
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with child maltreatment (physical abuse, sexual abuse, psychological
abuse, neglect)
Caregiver–child relationship problem includes parenting behaviours that are within the normal
range given the sociocultural context but that nonetheless have a negative impact on the child.
Some caregiving behaviours may be appropriate for many children, but not for the specific child.
These caregiver behaviours do not meet the diagnostic requirements for any child maltreatment
category. In contrast, in child psychological maltreatment, one or more verbal or symbolic acts
of parenting are clearly outside cultural norms, and are – or have reasonable potential to be –
harmful to the child. If diagnostic requirements for both caregiver–child relationship problem
and a form of child maltreatment are met, both may be assigned.
Boundary with oppositional defiant disorder
Oppositional defiant disorder is characterized by a pattern of markedly noncompliant, defiant
and disobedient disruptive behaviour that is not typical for individuals of comparable age and
developmental level. Similar behaviours may be observed in the context of caregiver–child
relationship problem, but these are often confined to the specific caregiver–child relationship.
In addition, in caregiver–child relationship problem there is often evidence that caregiver
behaviours are not optimal for the child. However, if diagnostic requirements for both caregiver–
child relationship problem and oppositional defiant disorder are met, both may be assigned.
Boundary with reactive attachment disorder and disinhibited social engagement
disorder
Reactive attachment disorder and disinhibited social engagement disorder are characterized by
a history of grossly insufficient care associated with markedly abnormal attachment behaviours
exhibited towards adult caregivers, with onset prior to the age of 5 years. Similar abnormal
attachment behaviours may be observed in caregiver–child relationship problem. However, if
all diagnostic requirements for reactive attachment disorder or disinhibited social engagement
disorder are met, a diagnosis of caregiver–child relationship problem is typically not warranted.
Physical maltreatment of child or personal history of physical abuse
as a child
Essential (required) features
• At least one non-accidental act of physical force (e.g. pushing or shoving, slapping,
punching, throwing something that could cause injury) towards a child or adolescent is
required for diagnosis.
Problems in relationship between child and current former caregiver and current or past child maltreatment
PJ20 /
QE82.0
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• The act causes (or exacerbates) at least one of the following:
• any physical injury (e.g. bruises, cuts, sprains, broken bones, loss of consciousness, pain
that lasts for several hours);
• significant fear;
• reasonable potential for significant physical injury.
• The act was not committed for physical self-protection (e.g. to ward off an adolescent’s
punches) or to protect the child or adolescent (e.g. to prevent a small child from running
into a busy street or to prevent an adolescent from attempting suicide).
Note: these categories are assigned to the victim, not the perpetrator.
If PJ20 Physical maltreatment is diagnosed, the perpetrator–victim relationship (e.g. parent,
other relative, stranger) should be specified using the extension codes provided on the ICD-11
platform in the context of the assault field. Similarly, if QE82.0 Personal history of physical abuse
is diagnosed, the time of life for current or past episodes (e.g. child aged under 5 years, early
adolescence) can be specified using the extension codes provided.
Additional clinical features
• Physical abuse of a child or adolescent can occur as an isolated incident. However, it can also
occur as a pattern of parental or caregiver behaviour. If identified in a child or adolescent, it
is important to evaluate whether past injuries were due to child physical abuse.
• There are numerous injury types that when presented in a child are likely to have been
caused by physical abuse. These include classic metaphyseal lesion (bucket handle fracture
of the long bone); femur – metaphyseal and spiral fractures; humerus – metaphyseal and
spiral fractures; rib fractures; spinous process fracture; skull – diastatic, across suture
lines; subdural/epidural injury; patterned burns; patterned bruising; retinal haemorrhage
(bilateral, multilayer). Many other injuries may also be caused by physical abuse of a child.
• Child physical abuse is associated with a variety of mental disorders, including depressive
disorders, adjustment disorder, anxiety and fear-related disorders, post-traumatic stress
disorder, oppositional defiant disorder and conduct-dissocial disorder, as well as attentional
problems, academic problems and suicidality.
• Among younger children, disturbances in attachment, difficulty separating from parents
or caregivers and vague physical complaints (stomach pain, headache) are more common
results of physical abuse than psychological symptoms.
Boundary with normality (threshold)
• Physical discipline (e.g. spanking following perceived negative behaviours of the child)
does not necessarily meet the diagnostic requirements for child physical abuse. Physical
discipline is differentiated from child physical abuse by its impact. If physical discipline
results in injury, has a reasonable potential for causing physical injury or elicits significant
fear, a diagnosis of child physical abuse may be warranted.
Problems in relationship between child and current former caregiver and current or past child maltreatment

12 - PJ21 Sexual maltreatment of child or QE82.1 P
PJ21 Sexual maltreatment of child or QE82.1 Personal history of sexual abuse as child
725
Relationship problems and maltreatment
Developmental presentations
• For infants or young children, distress associated with physical abuse may be exhibited
by persistent withdrawal from the caregiver, freezing behaviours or heightened reactivity
around the caregiver. The child may also exhibit an insecure or disorganized pattern of
attachment. A significant impact of physical abuse may be evidenced by lack of appropriate
developmental progression or even a loss of skills in infant or young child. Vague physical
complaints (stomach pain, headache) are also common.
• Symptoms of mental disorders are more likely among older children and adolescents who
experience physical abuse. Distress may also be manifested in physical aggression, poor
cooperation or oppositional behaviour towards the relevant caregiver; refusal to interact
with that caregiver; thoughts of running away or fantasies of having another caregiver;
inhibition, withdrawal or low self-esteem.
Sex- and/or gender-related features
• Although the impact of physical abuse can vary by gender (e.g. externalizing versus
internalizing symptoms), boys and girls are equally likely to be victims.
Sexual maltreatment of child or personal history of sexual abuse
as child
Essential (required) features
• At least one of the following acts involving an adult and a child is required for diagnosis:
• physical contact of a sexual nature between child and an adult – for example, vaginal or
anal penetration (or attempted penetration), oral-genital or oral-anal contact, fondling
(directly or through clothing);
• non-contact exploitation, involving an adult forcing, tricking, enticing, threatening or
pressuring a child to participate in acts for anyone’s sexual gratification without direct
physical contact between the child and the perpetrator – for example, exposing a child’s
genitals, anus or breasts; having a child masturbate or watch masturbation; having a child
participate in sexual activity with a third person (including child prostitution); having a
child pose, undress or perform in a sexual fashion (including child pornography).
Note: these categories are assigned to the victim, not the perpetrator.
If PJ21 Sexual maltreatment is diagnosed, the perpetrator–victim relationship (e.g. parent, other
relative, stranger) should be specified using the extension codes provided on the ICD-11 platform
Problems in relationship between child and current former caregiver and current or past child maltreatment
PJ21/
QE82.1
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
in the context of the assault field. Similarly, if QE82.1 Personal history of sexual abuse is diagnosed,
the time of life for current or past episodes (e.g. child aged under 5 years, early adolescence) can
be specified using the extension codes provided.
Additional clinical features
• Child sexual abuse is associated with a variety of mental disorders, including depressive
disorders, adjustment disorder, anxiety and fear-related disorders, post-traumatic stress
disorder, oppositional defiant disorder and conduct-dissocial disorder, as well as attentional
problems, academic problems and suicidality.
• Sexual abuse that includes physical contact and penetration can result in genital or anal
injuries, sexually transmitted diseases and pregnancy.
Boundary with normality (threshold)
• Mutual sex play between age mates is not considered sexual abuse. Sexual activity between
adolescent partners should not be diagnosed as child sexual abuse.
Developmental presentations
• Among younger children who experience sexual abuse, disturbances in attachment
(insecure or disorganized patterns, difficulty separating from parents or caregivers, and
vague physical complaints such as stomach pain or headache) are more common than
psychological symptoms.
• Among older children and adolescents, psychological symptoms and externalizing
behaviours are more common reactions to sexual abuse.
Sex- and/or gender-related features
• Sexual abuse of girls is generally more common than sexual abuse of boys, although this
varies by country and culture.
Problems in relationship between child and current former caregiver and current or past child maltreatment

13 - PJ22 Psychological maltreatment of child or Q
PJ22 Psychological maltreatment of child or QE82.2 Personal history of psychological abuse as child
727
Relationship problems and maltreatment
Psychological maltreatment of child or personal history of
psychological abuse as child
Essential (required) features
• Verbal or symbolic acts with the potential to cause psychological harm to a child or
adolescent are required for diagnosis. Examples include:
• berating, disparaging, degrading, humiliating the child;
• threatening the child (e.g. indicating or implying future physical harm, abandonment,
sexual assault);
• harming or abandoning – or threatening to harm or abandon – people or things that the
child cares about, such as pets, property, loved ones (e.g. exposing a child to spouse or
partner maltreatment);
• confining the child (e.g. typing a child’s arms or legs together; binding a child to a chair,
bed or other object; confining a child to an small enclosed area such as a closet);
• scapegoating the child (i.e. blaming child for things for which they cannot possibly be
responsible);
• coercing the child to inflict pain on themselves;
• disciplining the child excessively through physical or non-physical means (e.g. extremely
high frequency or duration), without necessarily meeting diagnostic requirements for
physical maltreatment.
• The acts cause (or exacerbate) at least one of the following:
• significant fear;
• significant psychological distress;
• somatic symptoms that interfere with normal functioning;
• significant avoidance or reluctance to engage in one or more major life activities (e.g.
work, education, religion, medical or mental services, contact with family members) to
avoid recurrence of the acts.
Note: these categories are assigned to the victim, not the perpetrator.
If PJ22 Psychological maltreatment is diagnosed, the perpetrator–victim relationship (e.g. parent,
other relative, stranger) should be specified using the extension codes provided on the ICD-11
platform in the context of the assault field. Similarly, if QE82.2 Personal history of psychological
abuse is diagnosed, the time of life for current or past episodes (e.g. child aged under 5 years, early
adolescence) can be specified using the extension codes provided.
Additional clinical features
• Child psychological abuse typically represents a pattern of parental or caregiver behaviours.
However, it may be diagnosed based on single episode if it is sufficiently impactful (e.g.
harming a pet to punish the child).
PJ22 /
QE82.2
Problems in relationship between child and current former caregiver and current or past child maltreatment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
• Child psychological abuse is associated with a variety of mental disorders, including
depressive disorders, adjustment disorder, anxiety and fear-related disorders, posttraumatic stress disorder, oppositional defiant disorder and conduct-dissocial disorder, as
well as attentional problems, academic problems and suicidality.
Boundary with normality (threshold)
• Child psychological abuse is characterized by one or more verbal or symbolic acts, generally
outside the sociocultural norms for parenting, that are – or have reasonable potential to be
– harmful to the child. In contrast, whereas normal discipline may be upsetting to children,
unlike psychological maltreatment it does not cause psychological harm, have the potential
to cause psychological harm, result in somatic symptoms or interfere with functioning.
Developmental presentations
• For infants or young children, distress associated with psychological abuse may be
exhibited by persistent withdrawal from the caregiver, freezing behaviours or heightened
reactivity around the caregiver. The child may also exhibit an insecure or disorganized
pattern of attachment. A significant impact of psychological abuse may be evidenced by
lack of appropriate developmental progression or even a loss of skills in infant or young
child. Vague physical complaints (stomach pain, headache) are also common.
• Symptoms of mental disorders are more likely among older children and adolescents who
experience psychological abuse. Distress may also be manifested in physical aggression,
poor cooperation or oppositional behaviour towards the relevant caregiver; refusal to
interact with that caregiver; thoughts of running away or fantasies of having another
caregiver; inhibition, withdrawal or low self-esteem.
Sex- and/or gender-related features
• Although the nature of parental acts (e.g. restriction versus humiliation) and the impact
of psychological abuse can vary by gender, boys and girls are equally likely to be victims.
Problems in relationship between child and current former caregiver and current or past child maltreatment

14 - PF1B Assault by neglect or QE82.3 Personal hi
PF1B Assault by neglect or QE82.3 Personal history of neglect as a child
729
Relationship problems and maltreatment
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with caregiver–child relationship problem
Psychological maltreatment should be distinguished from caregiver–child relationship problem,
which – unlike psychological maltreatment – is characterized by parenting behaviours that are
within the normal range for the sociocultural context but may still have a negative impact on
the child.
Assault by neglect or personal history of neglect as a child
Essential (required) features
• At least one confirmed or suspected egregious act or omission by a child or adolescent’s
caregiver that deprives the child of needed age-appropriate care is required for diagnosis
(e.g. abandonment, lack of appropriate supervision; exposure to physical hazard; failure to
provide necessary education, health care, nourishment, shelter, clothing).
• The act or omission causes or exacerbates at least one of the following impacts:
• significant physical injury or reasonable potential for significant injury;
• other significant negative consequences to health (e.g. development of an illness directly
linked to the neglect, malnutrition) or reasonable potential for significant negative
consequences to health;
• significant fear or psychological distress;
• reasonable potential for significant psychological harm (e.g. development of a mental
disorder) or for significant disruption of the child’s physical, psychological, cognitive or
social development);
• somatic symptoms that interfere with normal functioning.
Note: this category is assigned to the victim, not the perpetrator.
If PF1B Assault by neglect is diagnosed, the perpetrator–victim relationship (e.g. parent, other
relative, stranger) should be specified using the extension codes provided on the ICD-11 platform
in the context of the assault field. Perpetrator should be specified as a parent, other relative,
unrelated caregiver, or official or legal authority using the available extension codes. Depending
on the specific situation, PB5B Unintentional neglect or PH7B Neglect with undetermined intent
may be diagnosed rather than PF1B Assault by neglect. If QE82.3 Personal history of neglect
is diagnosed, the time of life for current or past episodes (e.g. child aged under 5 years, early
adolescence) can be specified using the extension codes provided.
PF1B /
QE82.3
Problems in relationship between child and current former caregiver and current or past child maltreatment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Additional clinical features
• Victims of child neglect can present with severe (chronically untreated) dental caries, ear
infections or other typical childhood illnesses.
• Child neglect is associated with a variety of mental disorders, including depressive
disorders, adjustment disorder, anxiety and fear-related disorders, post-traumatic stress
disorder, oppositional defiant disorder, conduct-dissocial disorder, attentional problems,
academic problems and suicidality.
Boundary with normality (threshold)
• Parents or other caregivers may provide less than optimal care for their children for brief
periods due to caregiver illness or stress. However, normal caregiving requires that they
make other arrangements if their own caregiving will be compromised for more than a
brief period. If a child is in danger, or is suffering significant harm as a result of inadequate
caregiving, the omissions in caregiving should be diagnosed as neglect.
Developmental presentations
• Children of any age can experience neglect. Neglected children may appear mature for
their age, but may also exhibit stunted growth due to lack of adequate nutrition or other
developmental deficits.
• Failure to meet developmental milestones can be a marker of neglect, as can attachment
problems (insecure or disorganized patterns), difficulty separating from parents or
caregivers, social skills deficits, behaviour problems and scholastic problems.
Course features
• Although one incident is sufficient to meet the diagnostic requirements, incidents of child
neglect often occur as part of a persistent pattern, which substantially increases the risk of
mental disorders, medical conditions and disrupted development.
Problems in relationship between child and current former caregiver and current or past child maltreatment
731
Relationship problems and maltreatment
Sex- and/or gender-related features
• Although its impact can vary by gender, boys and girls are equally likely to be victims
of neglect.
Boundaries with other disorders and conditions (differential diagnosis)
Boundary with caregiver–child relationship problem
Neglect is characterized by egregious acts or omissions that result in – or have significant potential
to result in – negative impacts. A diagnosis of caregiver–child relationship problem is generally
more appropriate for children of caregivers who are emotionally neglectful (e.g. not engaging
in positive interactions with the child) but have not committed egregious acts or omissions that
deprive the child or adolescent of age-appropriate care.
Boundary with reactive attachment disorder and disinhibited social engagement
disorder
Both reactive attachment disorder and disinhibited social engagement disorder are considered to
result from a history of grossly insufficient care in early childhood, including persistent disregard
for the child’s basic emotional or physical needs. They can occur in the context of repeated
changes of foster care or rearing in institutional settings that prevent the formation of stable
selective attachments, as well as in dyadic caregiver relationships. The insufficient care would
meet the diagnostic requirements for neglect and possibly also for other forms of maltreatment.
Both reactive attachment disorder and disinhibited social engagement disorder are characterized
by markedly abnormal attachment behaviours towards adult caregivers that are evident by the age
of 5 years. In reactive attachment disorder, there is a persistent and pervasive pattern of inhibited,
emotionally withdrawn behaviour, including minimal seeking of comfort when distressed and
rare or minimal response to comfort when it is offered. In disinhibited social engagement disorder,
there is a persistent and pervasive pattern of markedly abnormal social behaviours, in which
the child displays reduced or absent reticence in approaching and interacting with unfamiliar
adults. If the diagnostic requirements are met for reactive attachment disorder or disinhibited
social engagement disorder, that diagnosis should be assigned. An additional diagnosis of
assault by neglect or personal history of neglect may be assigned if it is relevant to the particular
clinical situation.
Problems in relationship between child and current former caregiver and current or past child maltreatment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

08 - Factors influencing health status or contact with

01 - Reasons for contact with mental health servic
Reasons for contact with mental health services

02 - Problems associated with relationships
Problems associated with relationships
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
relate to recognized social determinants of mental health – that is, risk factors for the development,
maintenance or moderation of symptoms of mental disorders across the lifespan.
The categories in this list are ordered in a way that is intended to make the list useful to mental
health professionals and does not correspond entirely to their ordering in ICD-11.7 Not all of the
categories include brief descriptions or definitions; where they are provided, they are included in
this section.
Reasons for contact with mental health services
Problems associated with relationships
(See the section on relationship problems and maltreatment, p. 707.)
Problems associated with interactions with spouse or partner
Relationship distress with spouse or partner
History of spouse or partner violence
Problems associated with interpersonal interactions in childhood
Caregiver–child relationship problem
Loss of love relationship in childhood
• Loss of love relationship in childhood refers to the loss of an emotionally close relationship,
such as of a parent, a sibling, a very special friend or a loved pet, by death or permanent
departure or rejection.
See ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS) [website]. Geneva: World Health Organization; 2023 (https://ICD.
who.int/browse11/l-m/en#/).
QE51
QE51.0
QE51.1
QE52
QE52.0
QE52.1
Reasons for contact with mental health services | Problems associated with relationships

03 - Problems associated with absence, loss or dea
Problems associated with absence, loss or death of others
735
Factors influencing health status or contact with health services particularly relevant to mental health services
Problems associated with interpersonal interactions
Note: relationship distress with spouse or partner and caregiver–child relationship problem
should be documented using the categories provided in the section on relationship problems and
maltreatment (p. 707).
Problem associated with relationship with friend
Problem associated with relationship with teachers or classmates
Problem associated with relationship with people at work
Problem associated with relationship with neighbours, tenant or landlord
Problem associated with relationship with parents, in-laws or other family
members
Discord with counsellors
Inadequate social skills
Other specified problems associated with relationships
Problems associated with relationships, unspecified
Problems associated with absence, loss or death of others
Absence of family member
Disappearance or death of family member
Loss or death of child
Disappearance or death of other family member
QE50
QE50.0
QE50.1
QE50.2
QE50.3
QE50.4
QE50.5
QE50.6
QE5Y
QE5Z
Reasons for contact with mental health services | Problems associated with absence, loss or death of others
QE60
QE61
QE61.0
QE61.Y

04 - Problems related to primary support group, in
Problems related to primary support group, including family circumstances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Uncomplicated bereavement
Note: uncomplicated bereavement refers to grief reactions experienced following the disappearance
or death of a loved one. In contrast, QE61 Disappearance or death of family member and its
subcategories refer to the event itself.
Other specified problems associated with absence, loss or death
of others
Problems associated with absence, loss or death of others,
unspecified
Problems related to primary support group, including
family circumstances
Problems related to primary support group, including family
circumstances
Inadequate family support
Disruption of family by separation or divorce
Dependent relative needing care at home
Problem related to primary support group, including family circumstance,
unspecified
QE6Y
QE6Z
QE70
Reasons for contact with mental health services | Problems related to primary support group
QE62
QE70.0
QE70.1
QE70.2
QE70.Z

05 - Problems associated with upbringing
Problems associated with upbringing
737
Factors influencing health status or contact with health services particularly relevant to mental health services
Problems associated with upbringing
Inadequate parental supervision or control
• Inadequate parental supervision or control refers to a lack of parental knowledge of what
the child is doing or where the child is; poor control; lack of concern, understanding or
comprehension or lack of attempted intervention when the child is in risky situations.
Parental overprotection
Altered pattern of family relationships in childhood
• Altered pattern of family relationships in childhood refers to the departure of a family
member or arrival of a new person into a family, resulting in adverse change in child’s
relationships – may include new relationship or marriage by a parent, death or illness of a
parent, illness or birth of a sibling.
Removal from home in childhood
Institutional upbringing
• Institutional upbringing refers to group foster care in which parenting responsibilities are
largely taken over by some form of institution (such as residential nursery, orphanage or
children’s home), or therapeutic care over a prolonged period in which the child is in a
hospital, convalescent home or the like, without at least one parent living with the child.
Inappropriate parental pressure or other abnormal qualities of upbringing
• Inappropriate parental pressure or other abnormal qualities of upbringing refers to
parents forcing the child to be different from the local norm – either sex-inappropriate
(e.g. dressing a boy in girl’s clothes), age-inappropriate (e.g. forcing a child to take on
responsibilities above their own age) or otherwise inappropriate (e.g. pressing the child to
engage in unwanted or too difficult activities).
Reasons for contact with mental health services | Problems associated with upbringing
QE90
QE91
QE92
QE93
QE94
QE95

06 - Problems associated with harmful or traumatic
Problems associated with harmful or traumatic events
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Events resulting in loss of self-esteem in childhood
• Events resulting in loss of self-esteem in childhood refers to events resulting in a negative
self-reappraisal by the child, such as failure in tasks with high personal investment;
disclosure or discovery of a shameful or stigmatizing personal or family event; or other
humiliating experiences.
Other specified problems associated with upbringing
Problems associated with upbringing, unspecified
Problems associated with harmful or traumatic events
Personal experience of being a victim of crime or terrorism
Exposure to disaster, war or other hostilities
Personal history of maltreatment
See the section on relationship problems and maltreatment, p. 707
Personal frightening experience in childhood
Acute stress reaction
See the section on disorders specifically associated with stress, p. 361, for the full CDDR.
• Acute stress reaction refers to the development of transient emotional, somatic, cognitive
or behavioural symptoms as a result of exposure to an event or situation (either short- or
long-lasting) of an extremely threatening or horrific nature (e.g. natural or human-made
disasters, combat, serious accidents, sexual violence, assault). Symptoms may include
QE96
QE9Y
QE9Z
QE80
QE81
QE82
QE83
Reasons for contact with mental health services | Problems associated with traumatic events
QE84

07 - Problems associated with social or cultural e
Problems associated with social or cultural environment
739
Factors influencing health status or contact with health services particularly relevant to mental health services
autonomic signs of anxiety (e.g. tachycardia, sweating, flushing), being in a daze, confusion,
sadness, anxiety, anger, despair, overactivity, inactivity, social withdrawal or stupor. The
response to the stressor is considered to be normal given the severity of the stressor, and
usually begins to subside within a few days after the event or following removal from the
threatening situation.
Other specified problems associated with harmful or traumatic events
Problems associated with harmful or traumatic events, unspecified
Problems associated with social or cultural environment
Acculturation difficulty
• Acculturation difficulty refers to problems resulting from the inability to adjust to a
different culture or environment.
Social role conflict
Social exclusion or rejection
• Social exclusion or rejection refers to exclusion and rejection on the basis of personal
characteristics such as physical appearance, sexual orientation, gender identity and
expression, illness or behaviour.
Personal experience of being a target of perceived adverse
discrimination or persecution
• Target of perceived adverse discrimination or persecution refers to persecution or
discrimination – real or perceived as reality by an individual – on the basis of membership
in some group (such as defined by skin colour, religion, ethnic origin, sexual orientation,
gender identity and expression) rather than personal characteristics.
QE9Y
QE9Z
QE00
QE02
Reasons for contact with mental health services | Problems associated with social or cultural environment
QE04
QE03

08 - Problems associated with employment or unempl
Problems associated with employment or unemployment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Other specified problems associated with social or cultural
environment
Problems associated with social or cultural environment, unspecified
Problems associated with employment or unemployment
Problems associated with unemployment
Problems associated with a change of job
Problems associated with threat of job loss
Problems with employment conditions
Problem associated with uncongenial work
Problem associated with stressful work schedule
Other specified problem with employment conditions
Occupational exposure to risk factors
Burnout
• Burnout is a syndrome conceptualized as resulting from chronic workplace stress that has
not been successfully managed. It is characterized by three dimensions: feelings of energy
depletion or exhaustion; increased mental distance from one’s job, or feelings of negativism
or cynicism related to one’s job; and a sense of ineffectiveness and lack of accomplishment.
Burnout refers specifically to phenomena in the occupational context and should not be
applied to describe experiences in other areas of life.
QE0Z
QE0Y
QD80
QD81
QD82
QD83
QD83.0
QD83.Y
QD83.1
QD85
QD84
Reasons for contact with mental health services | Problems associated with employment or unemployment

09 - Problems associated with education
Problems associated with education

10 - Other reasons for contact with mental health
Other reasons for contact with mental health services
741
Factors influencing health status or contact with health services particularly relevant to mental health services
Other specified problems associated with employment or
unemployment
Problems associated with employment or unemployment, unspecified
Problems associated with education
Problems associated with illiteracy or low-level literacy
Problems associated with unavailable or unattainable education
Problems with educational progress
Other specified problems associated with education
Problems associated with education, unspecified
Other reasons for contact with mental health services
Stress, not elsewhere classified
Discussion of issues surrounding impending death
Concern about or fear of medical treatment
Person with feared complaint in whom no diagnosis is made
QD8Y
QD8Z
QD90
QD91
Reasons for contact with mental health services | Problems associated with education | Other reasons for contact
QE01
QA1A
QA1B
QA1C
QD92
QD9Y
QD9Z

11 - Problems associated with health behaviours
Problems associated with health behaviours
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Concern about body appearance, unspecified
Personality difficulty
See the section on personality disorders and related traits, p. 553.
• Personality difficulty refers to pronounced personality characteristics that may affect
treatment or health services but do not rise to the level of severity to merit a diagnosis
of personality disorder. Personality difficulty is characterized by longstanding difficulties
(e.g. at least 2 years) in the individual’s way of experiencing and thinking about the self,
others and the world. In contrast to personality disorder, these difficulties are manifested
in cognitive and emotional experience and expression only intermittently (e.g. during
times of stress) or at low intensity. The difficulties are associated with some problems
in functioning, but these are insufficiently severe to cause notable disruption in social,
occupational and interpersonal relationships, or may be limited to specific relationships
or situations.
Malingering
• Malingering is the feigning, intentional production or significant exaggeration of physical
or psychological symptoms, or intentional misattribution of genuine symptoms to an
unrelated event or series of events when this is specifically motivated by external incentives
or rewards such as escaping duty or work, mitigating punishment, obtaining medications
or drugs, or receiving unmerited recompense such as disability compensation or personal
injury damages award.
Problems associated with health behaviours
Hazardous substance use
See the section on disorders due to substance use, p. 441.
Hazardous alcohol use
• Hazardous alcohol use refers to a pattern of alcohol use that appreciably increases the risk
of harmful physical or mental health consequences – to the user or to others – to an extent
QC30
QD3Z
QE50.7
QE10
Reasons for contact with mental health services | Problems associated with health behaviours
743
Factors influencing health status or contact with health services particularly relevant to mental health services
that warrants attention and advice from health professionals. The increased risk may be
from the frequency of alcohol use, from the amount used on a given occasion, from risky
behaviours associated with alcohol use or the context of use, or from a combination of
these. The risk may be related to short-term effects of alcohol or to longer-term cumulative
effects on physical or mental health or functioning. Hazardous alcohol use has not yet
reached the level of having caused harm to physical or mental health of the user or others
around the user. The pattern of alcohol use often persists in spite of awareness of increased
risk of harm to the user or to others.
Hazardous drug use
• Hazardous drug use refers to a pattern of use of psychoactive substances other than
nicotine or alcohol that appreciably increases the risk of harmful physical or mental health
consequences – to the user or to others – to an extent that warrants attention and advice
from health professionals. The increased risk may be from the frequency of substance
use, from the amount used on a given occasion, from risky behaviours associated with
substance use or the context of use, from a harmful route of administration, or from a
combination of these. The risk may be related to short-term effects of the substance or to
longer-term cumulative effects on physical or mental health or functioning. Hazardous
drug use has not yet reached the level of having caused harm to physical or mental health
of the user or others around the user. The pattern of drug use often persists in spite of
awareness of increased risk of harm to the user or to others.
Specify substance(s), if known:
QE11.0
Hazardous use of opioids
QE11.1
Hazardous use of cannabis
QE11.2
Hazardous use of sedatives, hypnotics or anxiolytics
QE11.3
Hazardous use of cocaine
QE11.4
Hazardous use of stimulants, including amfetamines, methamfetamine and
methcathinone
QE11.5
Hazardous use of caffeine
QE11.6
Hazardous use of MDMA or related drugs
QE11.7
Hazardous use of dissociative drugs, including ketamine and PCP
QE11.8
Hazardous use of other specified psychoactive substance
QE11.9
Hazardous use of unknown or unspecified psychoactive substance
QE11.Y Other specified hazardous drug use
QE11.Z Hazardous drug use, unspecified
Hazardous nicotine use
• Hazardous nicotine use refers to a pattern of nicotine use that appreciably increases the
risk of harmful physical or mental health consequences – to the user or to others – to an
extent that warrants attention and advice from health professionals. Most often nicotine
is consumed in the form of tobacco, but there are also other forms of nicotine delivery
(e.g. nicotine vapour). Hazardous nicotine use has not yet reached the level of having
caused harm to physical or mental health of the user or others around the user. The pattern
of nicotine use often persists in spite of awareness of increased risk of harm to the user
or to others. This category is not intended to include the use of nicotine replacement
therapies under medical supervision when these are used as part of attempts to stop or
reduce smoking.
QE11
Reasons for contact with mental health services | Problems associated with health behaviours
QE12
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Other specified hazardous substance use
Hazardous gambling or gaming
See the section on disorders due to addictive behaviours, p. 506.
Hazardous gambling or betting
• Hazardous gambling or betting refers to a pattern of gambling or betting that appreciably
increases the risk of harmful physical or mental health consequences to the individual or to
others around this individual. The increased risk may be from the frequency of gambling
or betting, from the amount of time spent on these activities or the context of gambling or
betting, from the neglect of other activities and priorities, from risky behaviours associated
with gambling or betting or its context, from the adverse consequences of gambling or
betting, or from a combination of these. The pattern of gambling or betting often persists
in spite of awareness of increased risk of harm to the individual or to others.
Hazardous gaming
• Hazardous gaming refers to a pattern of gaming, either online or offline that appreciably
increases the risk of harmful physical or mental health consequences to the individual or
to others around this individual. The increased risk may be from the frequency of gaming,
from the amount of time spent on these activities, from the neglect of other activities and
priorities, from risky behaviours associated with gaming or its context, from the adverse
consequences of gaming, or from a combination of these. The pattern of gaming often
persists in spite of awareness of increased risk of harm to the individual or to others.
QE1Y
QE21
QE22
Reasons for contact with mental health services | Hazardous gambling or betting

12 - Contact with health services for counselling
Contact with health services for counselling
745
Factors influencing health status or contact with health services particularly relevant to mental health services
Other problems associated with health behaviours
Lack of physical exercise
Problems with inappropriate diet or eating habits
Problems with hygiene behaviours
Problems with oral health behaviours
Problems with sun exposure behaviour
Problems with behaviours related to psychological health or
well-being
Problems with health literacy
Problems with other specified health-related behaviours
Problems with health-related behaviours, unspecified
Contact with health services for counselling
Contact with health services for dietary counselling or surveillance
Contact with health services for alcohol use counselling or
surveillance
Contact with health services for drug use counselling or surveillance
Contact with health services for tobacco use counselling
QE20
QE23
QE24
QE2Z
QE25
QE26
QE27
QE28
QE2Y
QA10
QA12
QA13
QA11
Reasons for contact with mental health services | Other problems associated with health behaviours
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Contact with health services for human immunodeficiency virus
counselling
• Human immunodeficiency virus counselling can be defined as accessible HIV counselling
services that meet the needs of clients and providers in an equitable and acceptable manner,
within the resources available and in line with national guidelines. Counselling should
increase knowledge of HIV prevention and should help the client to focus on solutions to
risk reduction.
Counselling related to sexuality
Counselling related to sexual attitudes
Counselling related to sexual behaviour and orientation or sexual
relationships of the person
Counselling related to sexual behaviour and orientation or sexual
relationships of the person of third party
Counselling related to combined sexual attitudes, sexual behaviour and
sexual relationships
Other specified counselling related to sexuality
Counselling related to sexuality, unspecified
Individual psychological or behavioural counselling
Marital or couples counselling
Family counselling
Group counselling
Contact with health services for other specified counselling
Contact with health services for unspecified counselling
QA15
QA15.0
QA14
QA15.1
QA15.2
QA15.3
QA15.Y
QA15.Z
QA16
QA17
QA18
QA19
QA1Y
QA1Z
Reasons for contact with mental health services | Other problems associated with health behaviours

13 - Contact with health services for reasons asso
Contact with health services for reasons associated with reproduction

14 - Problems associated with social insurance or
Problems associated with social insurance or welfare
747
Factors influencing health status or contact with health services particularly relevant to mental health services
Contact with health services for reasons
associated with reproduction8
Contact with health services for concerns about pregnancy
Contact with health services for contraceptive management
Contact with health services for medically assisted reproduction
Problems associated with social insurance or welfare
Insufficient social insurance support
Insufficient social insurance support, aged
Insufficient social insurance support, disability
Insufficient social insurance support, unemployment
Insufficient social insurance support, family support
Insufficient social welfare support
Insufficient social welfare support, child protection
Insufficient social welfare support, protection against domestic violence
Insufficient social welfare support, protection against homelessness
Insufficient social welfare support, post prison services
A detailed listing of categories in this section can be found at ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS)
[website]. Geneva: World Health Organization; 2023 (https://ICD.who.int/browse11/l-m/en#/).
QA20
QA21
QA30
QE30
QE30.0
QE30.1
QE30.2
QE30.4
QE31
QE31.0
QE31.1
QE31.2
QE31.3
Reasons for contact with mental health services | Problems associated with social insurance or welfare

15 - Problems associated with the justice system
Problems associated with the justice system

16 - Problems associated with finances
Problems associated with finances
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Other specified problems associated with social insurance or welfare
Problems associated with social insurance or welfare, unspecified
Problems associated with the justice system
Problems associated with conviction in civil or criminal proceedings
without imprisonment
Problems associated with imprisonment and other incarceration
Problems associated with release from prison
Other specified problems associated with the justice system
Problems associated with the justice system, unspecified
Problems associated with finances
Poverty
Low income
Other specified problems associated with finances
Problems associated with finances, unspecified
QE3Y
QE3Z
QE40
QE41
QE42
QD50
QD51
QD5Y
QD5Z
QE4Y
QE4Z
Reasons for contact with mental health services | Problems associated with the justice system/with finances

17 - Problems associated with inadequate drinking
Problems associated with inadequate drinking-water or nutrition

18 - Problems associated with the environment
Problems associated with the environment
749
Factors influencing health status or contact with health services particularly relevant to mental health services
Problems associated with inadequate drinking-water
or nutrition
Problems associated with inadequate drinking-water
Inadequate food
Problems associated with drinking-water or nutrition, unspecified
Problems associated with the environment
Problems associated with the natural environment or human-made
changes to the environment
Problem associated with exposure to noise
Problem associated with exposure to air pollution
Problem associated with exposure to water pollution
Problem associated with exposure to soil pollution
Problem associated with exposure to exposure to radiation
Problem associated with exposure to exposure to tobacco smoke
Note: this refers to second-hand smoke, and not to tobacco use by the individual.
Problem associated with inadequate access to electricity
Problem associated with the natural environment or human-made changes
to the environment, unspecified
QD60
QD61
QD6Z
QD70.1
QD70.3
QD70.4
QD70.5
QD70.6
QD70.2
QD70
QD70.0
QD70.Z
Problems associated with inadequate drinking-water, nutrition or the environment
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
Problems associated with housing
Homelessness
Inadequate housing
Problem related to living in a residential institution
Problem associated with housing, unspecified
Other specified problems associated with the environment
Problems associated with the environment, unspecified
Reasons for contact with mental health services | Problems associated with the environment
QD71
QD71.0
QD71.1
QD71.2
QD71.Z
QD7Y
QD7Z
751
Factors influencing health status or contact with health services particularly relevant to mental health services
Factors influencing health status or contact with health services particularly relevant to mental health services
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders

09 - Crosswalk from ICD 11 mental, behavioural and neur

01 - Crosswalk from ICD 11 mental, behavioural and
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10
753
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
Crosswalk from ICD-11
mental, behavioural and
neurodevelopmental disorders
to ICD-10 for clinician use
This table provides a crosswalk or mapping specifically designed for use by clinicians from
categories in this ICD-11 chapter on mental, behavioural and neurodevelopmental disorders to
the nearest equivalent ICD-10 category. This will be useful, for example, in settings where there
has been a shift to use of ICD-11 for clinical purposes, but where data or health reporting systems
are still in transition and require the use of ICD-10 codes.
Use of this table assumes that the clinician has already made their diagnosis according to the
ICD-11 CDDR. This table is not valid for mapping categories from the ICD-10 mental and
behavioural disorders to ICD-11 because it does not reflect the full content of the ICD-10 mental
and behavioural disorders.
This crosswalk is not intended for use in health statistics or in the coding of medical records
because, in a substantial number of instances, selecting among multiple possible ICD-10
categories depends on clinical information that will not be available in those contexts. Additional
information to assist clinicians in making these distinctions is provided in the “Notes” column
on the right.
In the table that follows, the ICD-11 categories are listed in the left column in the order in which
they appear in the classification. The closest available ICD-10 category to represent that ICD-11
disorder (i.e. the preferred code) is provided as the first entry in the middle column. Many of these
are 4-character ICD-10 codes (e.g. F80.1), but in other instances a 3-character code (e.g. F20) or
a 5-character code (e.g. F10.24) best captures the ICD-11 category. Where ICD-10 5-character
codes appear, these are taken from The ICD-10 classification of mental and behavioural disorders:
clinical descriptions and diagnostic guidelines, which in some cases include more detailed coding
options than the statistical version of ICD-10.
Data systems and/or reporting requirements in some health systems and countries may require
that 4-character ICD-10 codes are used if they are available, so that a 3-character code is not
accepted if a 4-character subcategory exists. Similarly, many data systems do not accept 5-character
ICD-10 codes, allowing a maximum of 4 characters. In situations in which the nearest equivalent
ICD-10 category is not a 4-character code, a 4-character coding option is also provided.
Additional coding or reporting requirements vary widely across settings and countries.
The mappings provided here may therefore require adjustment based on the requirements of the
specific clinical setting. This crosswalk is not intended to contravene any guidance that may be
provided by the relevant health system or government.
In a couple of specific instances (e.g. ICD-11 Body dysmorphic disorder), coding information
provided in The ICD-10 classification of mental and behavioural disorders: clinical descriptions and
diagnostic guidelines is not consistent with current evidence. The mappings provided in the table
are consistent with the ICD-11 conceptualizations in these cases, with such deviations described
in the “Notes” column.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
Neurodevelopmental disorders
6A00 Disorders of intellectual development
6A00.0 Disorder of intellectual development, mild
F70 Mild mental retardation
4-character code: F70.9 Mild mental retardation without
mention of impairment of behaviour
6A00.1 Disorder of intellectual development, moderate
F71 Moderate mental retardation
4-character code: F71.9 Moderate mental retardation without
mention of impairment of behaviour
6A00.2 Disorder of intellectual development, severe
F72 Severe mental retardation
4-character code: F72.9 Severe mental retardation without
mention of impairment of behaviour
6A00.3 Disorder of intellectual development, profound
F73 Profound mental retardation
4-character code: F73.9 Profound mental retardation without
mention of impairment of behaviour
6A00.4 Disorder of intellectual development,
provisional
F78 Other mental retardation
4-character code: F78.9 Other mental retardation without
mention of impairment of behaviour
6A00.Z Disorder of intellectual development,
unspecified
F79 Unspecified mental retardation
4-character code: F79.9 Unspecified mental retardation
without mention of impairment of behaviour
6A01 Developmental speech and language
disorders
F80 Specific developmental disorders of speech and
language
6A01.0 Developmental speech sound disorder
F80.0 Specific speech articulation disorder
6A01.1 Developmental speech fluency disorder
F98.5 Stuttering [stammering]
AND/OR
F98.6 Cluttering
Select the appropriate
category based on
clinical presentation.
There is no diagnostic
distinction in ICD11 between the
forms of speech
dysfluency described
in ICD-10 as stuttering
and cluttering.
755
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6A01.2 Developmental language disorder
See below
For clinical purposes,
the type of language
impairment (e.g.
receptive, expressive,
other) should be
specified. If no
information is available
about the type of
language impairment,
F80.9 Developmental
disorder of speech or
language, unspecified,
can be used.
6A01.20 Developmental language disorder with
impairment of receptive and expressive language
F80.1 Expressive language disorder
AND
F80.2 Receptive language disorder
6A01.21 Developmental language disorder with
impairment of mainly expressive language
F80.1 Expressive language disorder
6A01.22 Developmental language disorder with
impairment of mainly pragmatic language
F80.8 Other developmental disorders of speech and language
6A01.23 Developmental language disorder with other
specified language impairment
F80.8 Other developmental disorders of speech and language
6A01.Y Other specified developmental speech or
language disorder
F80.8 Other developmental disorders of speech and language
6A01.Z Developmental speech or language disorder,
unspecified
F80.9 Developmental disorder of speech and language,
unspecified
6A02 Autism spectrum disorder
F84.0 Childhood autism
OR
F84.1 Atypical autism
OR
F84.5 Asperger syndrome
Use F84.1 if it is unclear
that onset was prior
to the age of 3 years
(keeping in mind that
people may come to
clinical attention much
later). Regardless of
onset, use F84.5 if there
is no general impairment
in intellectual
functioning or functional
language.
6A02.0 Autism spectrum disorder without disorder
of intellectual development and with mild or no
impairment of functional language
F84.5 Asperger syndrome
6A02.1 Autism spectrum disorder with disorder
of intellectual development and with mild or no
impairment of functional language
F84.0 Childhood autism
OR
F84.1 Atypical autism
Use F84.1 if it is unclear
that onset was prior
to the age of 3 years
(keeping in mind that
people may come to
clinical attention much
later).
6A02.2 Autism spectrum disorder without disorder of
intellectual development and with impaired functional
language
F84.0 Childhood autism
OR
F84.1 Atypical autism
Use F84.1 if it is unclear
that onset was prior
to the age of 3 years
(keeping in mind that
people may come to
clinical attention much
later).
6A02.3 Autism spectrum disorder with disorder of
intellectual development and with impaired functional
language
F84.0 Childhood autism
OR
F84.1 Atypical autism
Use F84.1 if it is unclear
that onset was prior
to the age of 3 years
(keeping in mind that
people may come to
clinical attention much
later).
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6A02.5 Autism spectrum disorder with disorder of
intellectual development and with complete, or almost
complete, absence of functional language
F84.0 Childhood autism
OR
F84.1 Atypical autism
Use F84.1 if it is unclear
that onset was prior
to the age of 3 years
(keeping in mind that
people may come to
clinical attention much
later).
6A02.Y Other specified autism spectrum disorder
F84.0 Childhood autism
OR
F84.1 Atypical autism
OR
F84.5 Asperger syndrome
Use F84.1 if it is unclear
that onset was prior
to the age of 3 years
(keeping in mind that
people may come to
clinical attention much
later). Regardless of
onset, use F84.5 if there
is no general impairment
in intellectual
functioning or functional
language.
6A02.Z Autism spectrum disorder, unspecified
F84.9 Pervasive developmental disorder, unspecified
6A03 Developmental learning disorder
F81 Specific developmental disorders of scholastic skills
6A03.0 Developmental learning disorder with
impairment in reading
F81.0 Specific reading disorder
6A03.1 Developmental learning disorder with
impairment in written expression
F81.1 Specific spelling disorder
AND/OR
F81.8 Other developmental disorders of scholastic skills
ICD-11 6A03.1 also
includes expressive
writing impairment.
If the impairment is
in an area other than
spelling, then F81.8
Other developmental
disorders of scholastic
skills may be used
instead. Both ICD-10
diagnoses may be
assigned if appropriate.
6A03.2 Developmental learning disorder with
impairment in mathematics
F81.2 Specific disorder of arithmetical skills
6A03.3 Developmental learning disorder with other
specified impairment of learning
F81.8 Other developmental disorders of scholastic skills
6A03.Z Developmental learning disorder, unspecified
F81.9 Developmental disorder of scholastic skills, unspecified
6A04 Developmental motor coordination disorder
F82 Specific developmental disorder or motor function
6A05 Attention deficit hyperactivity disorder
F90 Hyperkinetic disorders
OR
F98.8 Other specified behavioural and emotional disorders
with onset usually occurring in childhood and adolescence
Use F98.8 if there
are no hyperactiveimpulsive symptoms.
6A05.0 Attention deficit hyperactivity disorder with
predominantly inattentive presentation
F90 Hyperkinetic disorders
OR
F98.8 Other specified behavioural and emotional disorders
with onset usually occurring in childhood and adolescence
Use F98.8 if there
are no hyperactiveimpulsive symptoms.
6A05.1 Attention deficit hyperactivity disorder with
predominantly hyperactive-impulsive presentation
F90.8 Other hyperkinetic disorder
6A05.2 Attention deficit hyperactivity disorder with
combined presentation
F90.0 Hyperkinetic disorder with disturbance of activity and
attention
757
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6A05.Y Attention deficit hyperactivity disorder with
other specified presentation
F90.8 Other hyperkinetic disorders
OR
F98.8 Other specified behavioural and emotional disorders
with onset usually occurring in childhood and adolescence
Use F98.8 if there
are no hyperactiveimpulsive symptoms.
6A05.Z Attention deficit hyperactivity disorder,
presentation unspecified
F98.9 Unspecified behavioural and emotional disorders with
onset usually occurring in childhood and adolescence
6A06 Stereotyped movement disorder
F98.4 Stereotyped movement disorders
6A06.0 Stereotyped movement disorder without selfinjury
F98.4 Stereotyped movement disorders
6A06.1 Stereotyped movement disorder with self-injury
F98.4 Stereotyped movement disorders
6A06.Z Stereotyped movement disorder, unspecified
F98.4 Stereotyped movement disorders
8A05.0 Primary tics and tic disorders
F95 Tic disorders
8A05.00 Tourette syndrome
F95.2 Combined vocal and multiple motor tic disorder [de la
Tourette]
8A05.01 Chronic motor tic disorder
F95.1 Chronic motor or vocal tic disorder
8A05.02 Chronic phonic tic disorder
F95.1 Chronic motor or vocal tic disorder
8A05.0Y Other specified primary tics and tic disorder
F95.8 Other tic disorders
8A05.0Z Primary tics and tic disorder, unspecified
F95.9 Tic disorder, unspecified
6A0Y Other specified neurodevelopmental disorder
F88 Other disorders of psychological development
No 4-character code available
6A0Z Neurodevelopmental disorder, unspecified
F89 Unspecified disorder of psychological development
No 4-character code available
Schizophrenia and other primary psychotic disorders
6A20 Schizophrenia
F20 Schizophrenia
4-character code: F20.9 Schizophrenia, unspecified
6A20.0 Schizophrenia, first episode
(including all subcategories 6A20.00–6A20.0Z)
F20 Schizophrenia
4-character code: F20.8 Other schizophrenia
6A20.1 Schizophrenia, multiple episodes
(including all subcategories 6A20.10–6A20.1Z)
F20 Schizophrenia
4-character code: F20.8 Other schizophrenia
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6A20.2 Schizophrenia, continuous
(including all subcategories 6A20.20–6A20.2Z)
F20 Schizophrenia
4-character code: F20.8 Other schizophrenia
6A20.Y Other specified episode of schizophrenia
F20 Schizophrenia
4-character code: F20.8 Other schizophrenia
6A20.Z Schizophrenia, episode unspecified
F20 Schizophrenia
4-character code: F20.8 Other schizophrenia
6A21 Schizoaffective disorder
F25 Schizoaffective disorders
4-character code: F25.9 Schizoaffective disorder, unspecified
6A21.0 Schizoaffective disorder, first episode
(including all subcategories 6A21.00–6A21.0Z)
F25 Schizoaffective disorders
4-character code: F25.8 Other schizoaffective disorders
6A21.1 Schizoaffective disorder, multiple episodes
(including all subcategories 6A21.10–6A21.1Z)
F25 Schizoaffective disorders
4-character code: F25.8 Other schizoaffective disorders
6A21.2 Schizoaffective disorder, continuous
(including all subcategories 6A21.20–6A21.2Z)
F25 Schizoaffective disorders
4-character code: F25.8 Other schizoaffective disorders
6A21.Y Other specified schizoaffective disorder
F25 Schizoaffective disorders
4-character code: F25.8 Other schizoaffective disorders
6A21.Z Schizoaffective disorder, unspecified
F25 Schizoaffective disorders
4-character code: F25.8 Other schizoaffective disorders
6A22 Schizotypal disorder
F21 Schizotypal disorder
No 4-character code available
6A23 Acute and transient psychotic disorder
F23.0 Acute polymorphic psychotic disorder without
symptoms of schizophrenia
6A23.0 Acute and transient psychotic disorder, first
episode
(including all subcategories 6A23.00–6A23.0Z)
F23.0 Acute polymorphic psychotic disorder without
symptoms of schizophrenia
6A23.1 Acute and transient psychotic disorder, multiple
episodes
(including all subcategories 6A23.10–6A23.1Z)
F23.0 Acute polymorphic psychotic disorder without
symptoms of schizophrenia
6A23.Y Other specified acute and transient psychotic
disorder
F23.0 Acute polymorphic psychotic disorder without
symptoms of schizophrenia
759
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6A23.Z Acute and transient psychotic disorder,
unspecified
F23.0 Acute polymorphic psychotic disorder without
symptoms of schizophrenia
6A24 Delusional disorder
F22.0 Delusional disorder
6A24.0 Delusional disorder, currently symptomatic
F22.0 Delusional disorder
6A24.1 Delusional disorder, in partial remission
F22.0 Delusional disorder
6A24.2 Delusional disorder, in full remission
F22.0 Delusional disorder
6A24.Z Delusional disorder, unspecified
F22.0 Delusional disorder
6A2Y Other specified primary psychotic disorder
F28 Other nonorganic psychotic disorders
No 4-character code available
6A2Z Schizophrenia or other primary psychotic
disorder, unspecified
F29 Unspecified nonorganic psychosis
No 4-character code available
Catatonia
6A40 Catatonia associated with another mental
disorder
F20.2 Catatonic schizophrenia
OR
F99 Mental disorder, not otherwise specified
F20.2 should only
be used when
the associated
mental disorder is
schizophrenia.
6A41 Catatonia induced by substances or
medications
F19.8 Other mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
6A4Z Catatonia, unspecified
F99 Mental disorder, not otherwise specified
Mood disorders
Bipolar and related disorders
6A60 Bipolar type I disorder
F31 Bipolar affective disorder
4-character code: F31.9 Bipolar affective disorder,
unspecified
6A60.0 Bipolar type I disorder, current episode manic,
without psychotic symptoms
F31.1 Bipolar affective disorder, current episode manic without
psychotic symptoms
6A60.1 Bipolar type I disorder, current episode manic,
with psychotic symptoms
F31.2 Bipolar affective disorder, current episode manic with
psychotic symptoms
6A60.2 Bipolar type I disorder, current episode
hypomanic
F31.0 Bipolar affective disorder, current episode hypomanic
6A60.3 Bipolar type I disorder, current episode
depressive, mild
F31.3 Bipolar affective disorder, current episode mild or
moderate depression
6A60.4 Bipolar type I disorder, current episode
depressive, moderate without psychotic symptoms
F31.3 Bipolar affective disorder, current episode mild or
moderate depression
6A60.5 Bipolar type I disorder, current episode
depressive, moderate with psychotic symptoms
F31.5 Bipolar affective disorder, current episode severe
depression with psychotic symptoms
In ICD-10, the presence
of psychotic symptoms
in the context of a
depressive episode
means that the episode
is automatically rated as
severe.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6A60.6 Bipolar type I disorder, current episode
depressive, severe without psychotic symptoms
F31.4 Bipolar affective disorder, current episode severe
depression without psychotic symptoms
6A60.7 Bipolar type I disorder, current episode
depressive, severe with psychotic symptoms
F31.5 Bipolar affective disorder, current episode severe
depression with psychotic symptoms
6A60.8 Bipolar type I disorder, current episode
depressive, unspecified severity
F31.9 Bipolar affective disorder, unspecified
6A60.9 Bipolar type I disorder, current episode mixed,
without psychotic symptoms
F31.6 Bipolar affective disorder, current episode mixed
6A60.A Bipolar type I disorder, current episode mixed,
with psychotic symptoms
F31.6 Bipolar affective disorder, current episode mixed
6A60.B Bipolar type I disorder, currently in partial
remission, most recent episode manic or hypomanic
F31.8 Other bipolar affective disorders
6A60.C Bipolar type I disorder, currently in partial
remission, most recent episode depressive
F31.8 Other bipolar affective disorders
6A60.D Bipolar type I disorder, currently in partial
remission, most recent episode mixed
F31.8 Other bipolar affective disorders
6A60.E Bipolar type I disorder, currently in partial
remission, most recent episode unspecified
F31.8 Other bipolar affective disorders
6A60.F Bipolar type I disorder, currently in full
remission
F31.7 Bipolar affective disorder, currently in remission
6A60.Y Other specified bipolar type I disorder
F31.8 Other bipolar affective disorders
6A60.Z Bipolar type I disorder, unspecified
F31.9 Bipolar affective disorder, unspecified
6A61 Bipolar type II disorder
F31 Bipolar affective disorder
6A61.0 Bipolar type II disorder, current episode
hypomanic
F31.0 Bipolar affective disorder, current episode hypomanic
6A61.1 Bipolar type II disorder, current episode
depressive, mild
F31.3 Bipolar affective disorder, current episode mild or
moderate depression
6A61.2 Bipolar type II disorder, current episode
depressive, moderate without psychotic symptoms
F31.3 Bipolar affective disorder, current episode mild or
moderate depression
6A61.3 Bipolar type II disorder, current episode
depressive, moderate with psychotic symptoms
F31.5 Bipolar affective disorder, current episode severe
depression with psychotic symptoms
In ICD-10, the presence
of psychotic symptoms
in the context of a
depressive episode
means that the episode
is automatically rated as
severe.
6A61.4 Bipolar type II disorder, current episode
depressive, severe without psychotic symptoms
F31.4 Bipolar affective disorder, current episode severe
depression without psychotic symptoms
6A61.5 Bipolar type II disorder, current episode
depressive, severe with psychotic symptoms
F31.5 Bipolar affective disorder, current episode severe
depression with psychotic symptoms
6A61.6 Bipolar type II disorder, current episode
depressive, unspecified severity
F31.9 Bipolar affective disorder, unspecified
6A61.7 Bipolar type II disorder, currently in partial
remission, most recent episode hypomanic
F31.8 Other bipolar affective disorders
6A61.8 Bipolar type II disorder, currently in partial
remission, most recent episode depressive
F31.8 Other bipolar affective disorders
6A61.9 Bipolar type II disorder, currently in partial
remission, most recent episode unspecified
F31.8 Other bipolar affective disorders
6A61.A Bipolar type II disorder, currently in full
remission
F31.7 Bipolar affective disorder, currently in remission
6A61.Y Other specified bipolar type II disorder
F31.8 Other bipolar affective disorders
761
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6A61.Z Bipolar type II disorder, unspecified
F31.9 Bipolar affective disorder, unspecified
6A62 Cyclothymic disorder
F34.0 Cyclothymia
6A6Y Other specified bipolar or related disorder
F31.8 Other bipolar affective disorders
6A6Z Bipolar or related disorder, unspecified
F31.9 Bipolar affective disorder, unspecified
Depressive disorders
6A70 Single episode depressive disorder
F32 Depressive episode
4-character code: F32.9 Depressive episode, unspecified
6A70.0 Single episode depressive disorder, mild
F32.0 Mild depressive episode
6A70.1 Single episode depressive disorder, moderate,
without psychotic symptoms
F32.1 Moderate depressive episode
6A70.2 Single episode depressive disorder, moderate,
with psychotic symptoms
F32.3 Severe depressive episode with psychotic symptoms
In ICD-10, the presence
of psychotic symptoms
in the context of a
depressive episode
means that the episode
is automatically rated
as severe.
6A70.3 Single episode depressive disorder, severe,
without psychotic symptoms
F32.2 Severe depressive episode without psychotic
symptoms
6A70.4 Single episode depressive disorder, severe,
with psychotic symptoms
F32.3 Severe depressive episode with psychotic symptoms
6A70.5 Single episode depressive disorder, unspecified
severity
F32.9 Depressive episode, unspecified
6A70.6 Single episode depressive disorder, currently in
partial remission
F32.8 Other depressive episodes
6A70.7 Single episode depressive disorder, currently in
full remission
No diagnosis
In ICD-10, remission can
only apply to recurrent
depressive disorder.
If an ICD-10 code
must be provided,
the most appropriate
option would be F32.9
Depressive episode,
unspecified.
6A70.Y Other specified single episode depressive
disorder
F32.8 Other depressive episodes
6A70.Z Single episode depressive disorder, unspecified
F32.9 Depressive episode, unspecified
6A71 Recurrent depressive disorder
F33.0 Recurrent depressive disorder
OR
F33.9 Recurrent depressive disorder,
unspecified
6A71.0 Recurrent depressive disorder, current episode
mild
F33.0 Recurrent depressive disorder, current episode mild
6A71.1 Recurrent depressive disorder, current episode
moderate, without psychotic symptoms
F33.1 Recurrent depressive disorder, current episode
moderate
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6A71.2 Recurrent depressive disorder, current episode
moderate, with psychotic symptoms
F33.3 Recurrent depressive disorder, current episode severe
with psychotic symptoms
In ICD-10, the presence
of psychotic symptoms
in the context of a
depressive episode
means that the episode
is automatically rated
as severe.
6A71.3 Recurrent depressive disorder, current episode
severe, without psychotic symptoms
F33.2 Recurrent depressive disorder, current episode severe
without psychotic symptoms
6A71.4 Recurrent depressive disorder, current episode
severe, with psychotic symptoms
F33.3 Recurrent depressive disorder, current episode severe
with psychotic symptoms
6A71.5 Recurrent depressive disorder, current episode,
unspecified severity
F33.9 Recurrent depressive disorder,
unspecified
6A71.6 Recurrent depressive disorder, currently in
partial remission
F33.8 Other recurrent depressive disorders
6A71.7 Recurrent depressive disorder, currently in full
remission
F33.4 Recurrent depressive disorder, currently in remission
6A71.Y Other specified recurrent depressive disorder
F33.8 Other recurrent depressive disorders
6A71.Z Recurrent depressive disorder, unspecified
F33.9 Recurrent depressive disorder, unspecified
6A72 Dysthymic disorder
F34.1 Dysthymia
6A73 Mixed depressive and anxiety disorder
F41.2 Mixed anxiety and depressive disorder
6A7Y Other specified depressive disorder
F38.8 Other specified mood [affective] disorder
6A7Z Depressive disorder, unspecified
F39 Unspecified mood [affective] disorder
No 4-character code available
6A8Y Other specified mood disorder
F38.8 Other specified mood [affective] disorder
6A8Z Mood disorder, unspecified
F39 Unspecified mood [affective] disorder
No 4-character code available
Anxiety and fear-related disorders
6B00 Generalized anxiety disorder
F41.1 Generalized anxiety disorder
6B01 Panic disorder
F41.0 Panic disorder [episodic paroxysmal anxiety]
6B02 Agoraphobia
F40.0 Agoraphobia
6B03 Specific phobia
F40.2 Specific (isolated) phobias
OR
F93.1 Phobic anxiety disorder of childhood
Use F93.1 if the
individual is less than
18 years of age.
6B04 Social anxiety disorder
F40.1 Social phobias
OR
F93.2 Social anxiety disorder of childhood
Use F93.2 if the
individual is less than
6 years of age.
6B05 Separation anxiety disorder
F41.8 Other specified anxiety disorders
OR
F93.0 Separation anxiety disorder of childhood
Use F93.0 if the
individual is less than
6 years of age.
6B06 Selective mutism
F94.0 Elective mutism
763
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6B0Y Other specified anxiety or fear-related
disorder
F40.8 Other phobic anxiety disorders
OR
F41.8 Other specified anxiety disorders
Use F40.8 if there is
a specific external
stimulus or situation
that triggers the anxiety
symptoms; otherwise,
use 41.8.
6B0Z Anxiety or fear-related disorder, unspecified
F40.9 Phobic anxiety disorder, unspecified
OR
F41.9 Anxiety disorder, unspecified
Use F40.9 if there is
a specific external
stimulus or situation
that triggers the anxiety
symptoms; otherwise,
use 41.9.
Obsessive-compulsive and related disorders
6B20 Obsessive-compulsive disorder
F42 Obsessive-compulsive disorder
4-character code: F42.9 Obsessive-compulsive disorder,
unspecified
6B20.0 Obsessive-compulsive disorder with fair to
good insight
F42 Obsessive-compulsive disorder
4-character code: F42.9 Obsessive-compulsive disorder,
unspecified
6B20.1 Obsessive-compulsive disorder with poor to
absent insight
F42 Obsessive-compulsive disorder
4-character code: F42.9 Obsessive-compulsive disorder,
unspecified
6B20.Z Obsessive-compulsive disorder, unspecified
F42.9 Obsessive-compulsive disorder, unspecified
6B21 Body dysmorphic disorder
F42.8 Other obsessive-compulsive disorders
Mapping to F45.2
Hypochondriacal
disorder is inconsistent
with the ICD-11
conceptualization
of body dysmorphic
disorder.
6B21.0 Body dysmorphic disorder with fair to good
insight
F42.8 Other obsessive-compulsive disorders
6B21.1 Body dysmorphic disorder with poor to absent
insight
F42.8 Other obsessive-compulsive disorders
Mapping to F22.8 Other
persistent delusional
disorders is inconsistent
with the ICD-11
conceptualization
of body dysmorphic
disorder.
6B21.Z Body dysmorphic disorder, unspecified
F42.8 Other obsessive-compulsive disorders
6B22 Olfactory reference disorder
F42.8 Other obsessive-compulsive disorders
6B22.0 Olfactory reference disorder with fair to good
insight
F42.8 Other obsessive-compulsive disorders
6B22.1 Olfactory reference disorder with poor to
absent insight
F42.8 Other obsessive-compulsive disorders
6B22.Z Olfactory reference disorder, unspecified
F42.8 Other obsessive-compulsive disorders
6B23 Hypochondriasis
F45.2 Hypochondriacal disorder
6B23.0 Hypochondriasis with fair to good insight
F45.2 Hypochondriacal disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6B23.1 Hypochondriasis with poor to absent insight
F45.2 Hypochondriacal disorder
6B23.Z Hypochondriasis, unspecified
F45.2 Hypochondriacal disorder
6B24 Hoarding disorder
F42.8 Other obsessive-compulsive disorders
6B24.0 Hoarding disorder with fair to good insight
F42.8 Other obsessive-compulsive disorders
6B24.1 Hoarding disorder with poor to absent insight
F42.8 Other obsessive-compulsive disorders
6B24.Z Hoarding disorder, unspecified
F42.8 Other obsessive-compulsive disorders
6B25 Body-focused repetitive behaviour disorders
F63.8 Other habit and impulse disorders
6B25.0 Trichotillomania (hair-pulling disorder)
F63.3 Trichotillomania
6B25.1 Excoriation (skin-picking) disorder
F63.8 Other habit and impulse disorders
6B25.Y Other specified body-focused repetitive
behaviour disorder
F63.8 Other habit and impulse disorders
6B25.Z Body-focused repetitive behaviour disorder,
unspecified
F63.9 Habit and impulse disorder, unspecified
6B2Y Other specified obsessive-compulsive or
related disorder
F42.8 Other obsessive-compulsive disorders
6B2Z Obsessive-compulsive or related disorder,
unspecified
F42.9 Obsessive-compulsive disorder, unspecified
Disorders specifically associated with stress
6B40 Post-traumatic stress disorder
F43.1 Post-traumatic stress disorder
6B41 Complex post-traumatic stress disorder
F43.1 Post-traumatic stress disorder
AND
F62.0 Enduring personality change after catastrophic
experience
6B42 Prolonged grief disorder
F43.8 Other reactions to severe stress
Mapping to F43.2
Adjustment disorders
is inconsistent
with the ICD-11
conceptualization
of prolonged grief
disorder.
6B43 Adjustment disorder
F43.2 Adjustment disorders
6B44 Reactive attachment disorder
F94.1 Reactive attachment disorder of childhood
6B45 Disinhibited social engagement disorder
F94.2 Disinhibited attachment disorder of childhood
6B4Y Other specified disorder specifically
associated with stress
F43.8 Other reactions to severe stress
6B4Z Disorder specifically associated with stress,
unspecified
F43.9 Reaction to severe stress, unspecified
QE84 Acute stress reaction
F43.0 Acute stress reaction
Dissociative disorders
6B60 Dissociative neurological symptom disorder
F44.9 Dissociative [conversion] disorder, unspecified
6B60.0 Dissociative neurological symptom disorder
with visual disturbance
F44.6 Dissociative anaesthesia and sensory loss
6B60.1 Dissociative neurological symptom disorder
with auditory disturbance
F44.6 Dissociative anaesthesia and sensory loss
6B60.2 Dissociative neurological symptom disorder
with vertigo or dizziness
F44.6 Dissociative anaesthesia and sensory loss
765
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6B60.3 Dissociative neurological symptom disorder
with other sensory disturbance
F44.6 Dissociative anaesthesia and sensory loss
6B60.4 Dissociative neurological symptom disorder
with non-epileptic seizures
F44.5 Dissociative convulsions
6B60.5 Dissociative neurological symptom disorder
with speech disturbance
F44.4 Dissociative motor disorders
6B60.6 Dissociative neurological symptom disorder
with paresis or weakness
F44.4 Dissociative motor disorders
6B60.7 Dissociative neurological symptom disorder
with gait disturbance
F44.4 Dissociative motor disorders
6B60.8 Dissociative neurological symptom disorder
with movement disturbance
F44.4 Dissociative motor disorders
6B60.80 Dissociative neurological symptom disorder
with chorea
F44.4 Dissociative motor disorders
6B60.81 Dissociative neurological symptom disorder
with myoclonus
F44.4 Dissociative motor disorders
6B60.82 Dissociative neurological symptom disorder
with tremor
F44.4 Dissociative motor disorders
6B60.83 Dissociative neurological symptom disorder
with dystonia
F44.4 Dissociative motor disorders
6B60.84 Dissociative neurological symptom disorder
with facial spasm
F44.4 Dissociative motor disorders
6B60.85 Dissociative neurological symptom disorder
with parkinsonism
F44.4 Dissociative motor disorders
6B60.8Y Dissociative neurological symptom disorder
with other specified movement disturbance
F44.4 Dissociative motor disorders
6B60.8Z Dissociative neurological symptom disorder
with unspecified movement disturbance
F44.4 Dissociative motor disorders
6B60.9 Dissociative neurological symptom disorder
with cognitive symptoms
F44.8 Other dissociative [conversion] disorders
6B60.Y Dissociative neurological symptom disorder
with other specified symptoms
F44.8 Other dissociative [conversion] disorders
6B60.Z Dissociative neurological symptom disorder
with unspecified symptoms
F44.9 Dissociative [conversion] disorder, unspecified
6B61 Dissociative amnesia
F44.0 Dissociative amnesia
6B61.0 Dissociative amnesia with dissociative fugue
F44.1 Dissociative fugue
6B61.1 Dissociative amnesia without dissociative fugue
F44.0 Dissociative amnesia
6B61.Z Dissociative amnesia, unspecified
F44.0 Dissociative amnesia
6B62 Trance disorder
F44.3 Trance and possession disorders
6B63 Possession trance disorder
F44.3 Trance and possession disorders
6B64 Dissociative identity disorder
F44.81 Multiple personality disorder
4-character code: F44.8 Other dissociative [conversion]
disorder
6B65 Partial dissociative identity disorder
F44.8 Other dissociative [conversion] disorder
6B66 Depersonalization-derealization disorder
F48.1 Depersonalization-derealization syndrome
6B6Y Other specified dissociative disorder
F44.8 Other dissociative [conversion] disorders
6B6Z Dissociative disorder, unspecified
F44.9 Dissociative [conversion] disorder, unspecified
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
Feeding and eating disorders
6B80 Anorexia nervosa
F50.0 Anorexia nervosa
OR
F50.1 Atypical anorexia nervosa
For ICD-10 F50.0,
diagnostic requirements
include BMI of less than
17.5, plus: amenorrhoea
in women; loss of sexual
interest and erectile
dysfunction in men;
or delayed puberty in
adolescents. Otherwise,
use F50.1.
6B80.0 Anorexia nervosa with significantly low body
weight
F50.0 Anorexia nervosa
OR
F50.1 Atypical anorexia nervosa
See 6B80.
6B80.00 Anorexia nervosa with significantly low body
weight, restricting pattern
F50.0 Anorexia nervosa
OR
F50.1 Atypical anorexia nervosa
See 6B80.
6B80.01 Anorexia nervosa with significantly low body
weight, binge-purge pattern
F50.0 Anorexia nervosa
OR
F50.1 Atypical anorexia nervosa
See 6B80.
6B80.0Z Anorexia nervosa with significantly low body
weight, unspecified
F50.0 Anorexia nervosa
OR
F50.1 Atypical anorexia nervosa
See 6B80.
6B80.1 Anorexia nervosa with dangerously low body
weight
F50.0 Anorexia nervosa
6B80.10 Anorexia nervosa with dangerously low body
weight, restricting pattern
F50.0 Anorexia nervosa
6B80.11 Anorexia nervosa with dangerously low body
weight, binge-pure pattern
F50.0 Anorexia nervosa
6B80.1Z Anorexia nervosa with dangerously low body
weight, unspecified
F50.0 Anorexia nervosa
6B80.2 Anorexia nervosa in recovery with normal body
weight
F50.1 Atypical anorexia nervosa
6B80.Y Other specified anorexia nervosa
F50.1 Atypical anorexia nervosa
6B80.Z Anorexia nervosa, unspecified
F50.0 Anorexia nervosa
OR
F50.1 Atypical anorexia nervosa
For ICD-10 F50.0,
diagnostic requirements
include BMI of less than
17.5, plus: amenorrhoea
in women; loss of sexual
interest and erectile
dysfunction in men;
or delayed puberty in
adolescents. Otherwise,
use F50.1.
6B81 Bulimia nervosa
F50.2 Bulimia nervosa
6B82 Binge-eating disorder
F50.8 Other eating disorders
6B83 Avoidant-restrictive food intake disorder
F98.2 Feeding disorder of infancy or childhood
OR
F50.8 Other eating disorders
Use F98.2 if the
individual is less
than 12 years of age;
otherwise, use F50.8.
767
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6B84 Pica
F98.3 Pica of infancy and childhood
OR
F50.8 Other eating disorders
Use F98.3 if the
individual is less
than 12 years of age;
otherwise, use F50.8.
6B85 Rumination-regurgitation disorder
F98.2 Feeding disorder of infancy and childhood
OR
F50.8 Other eating disorders
Use F98.2 if the
individual is less
than 12 years of age;
otherwise, use F50.8.
6B8Y Other specified feeding or eating disorder
F50.8 Other eating disorders
6B8Z Feeding or eating disorder, unspecified
F50.9 Eating disorder, unspecified
Elimination disorders
6C00 Enuresis
F98.0 Nonorganic enuresis
6C00.0 Nocturnal enuresis
F98.0 Nonorganic enuresis
6C00.1 Diurnal enuresis
F98.0 Nonorganic enuresis
6C00.2 Nocturnal and diurnal enuresis
F98.0 Nonorganic enuresis
6C00.Z Enuresis, unspecified
F98.0 Nonorganic enuresis
6C01 Encopresis
F98.1 Nonorganic encopresis
6C01.0 Encopresis with constipation or overflow
incontinence
F98.1 Nonorganic encopresis
6C01.1 Encopresis without constipation or overflow
incontinence
F98.1 Nonorganic encopresis
6C01.Z Encopresis, unspecified
F98.1 Nonorganic encopresis
6C0Z Elimination disorder, unspecified
F98.1 Nonorganic encopresis
Disorders of bodily distress or bodily experience
6C20 Bodily distress disorder
F45.9 Somatoform disorder, unspecified
6C20.0 Mild bodily distress disorder
F45.4 Persistent somatoform pain disorder
OR
F45.9 Somatoform disorder, unspecified
Use F45.4 if the primary
symptom is pain.
6C20.1 Moderate bodily distress disorder
F45.4 Persistent somatoform pain disorder
OR
F45.9 Somatoform disorder, unspecified
Use F45.4 if the primary
symptom is pain.
6C20.2 Severe bodily distress disorder
F45.0 Somatization disorder
OR
F45.4 Persistent somatoform pain disorder
OR
F45.9 Somatoform disorder, unspecified
Use F45.4 if the primary
symptom is pain.
Use F45.0 if there is
a history of multiple
and variable bodily
symptoms.
6C20.Z Bodily distress disorder, unspecified
F45.9 Somatoform disorder, unspecified
6C21 Body integrity dysphoria
F99 Unspecified mental disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C2Y Other specified disorder of bodily distress or
bodily experience
F99 Unspecified mental disorder
No 4-character code available
6C2Z Disorder of bodily distress or bodily
experience, unspecified
F99 Unspecified mental disorder
No 4-character code available
Disorders due to substance use or addictive behaviours
Disorders due to substance use
6C40 Disorders due to use of alcohol
F10 Mental and behavioural disorders due to use of alcohol
6C40.0 Episode of harmful use of alcohol
F10.8 Mental and behavioural disorders due to use of alcohol:
other mental and behavioural disorders
6C40.1 Harmful pattern of use of alcohol
F10.1 Mental and behavioural disorders due to use of alcohol:
harmful use
6C40.10 Harmful pattern of use of alcohol, episodic
F10.1 Mental and behavioural disorders due to use of alcohol:
harmful use
6C40.11 Harmful pattern of use of alcohol, continuous
F10.1 Mental and behavioural disorders due to use of alcohol:
harmful use
6C40.1Z Harmful pattern of use of alcohol,
unspecified
F10.1 Mental and behavioural disorders due to use of alcohol:
harmful use
6C40.2 Alcohol dependence
F10.2 Mental and behavioural disorders due to use of alcohol:
dependence syndrome
6C40.20 Alcohol dependence, current use,
continuous
F10.25 Mental and behavioural disorders due to use of
alcohol: dependence syndrome, continuous use
4-character code: F10.2 Mental and behavioural disorders
due to use of alcohol: dependence syndrome
6C40.21 Alcohol dependence, current use, episodic
F10.26 Mental and behavioural disorders due to use of
alcohol: dependence syndrome episodic use
4-character code: F10.2 Mental and behavioural disorders
due to use of alcohol: dependence syndrome
6C40.22 Alcohol dependence, early full remission
F10.20 Mental and behavioural disorders due to use of
alcohol: dependence syndrome, currently abstinent
OR
F10.21 Mental and behavioural disorders due to use of
alcohol: dependence syndrome, currently abstinent, but in
a protected environment
OR
F10.23 Mental and behavioural disorders due to use of
alcohol: dependence syndrome, currently abstinent,
but receiving treatment with aversive or blocking
drugs (e.g. naltrexone or disulfiram)
4-character code: F10.2 Mental and behavioural disorders
due to use of alcohol: dependence syndrome
Select the appropriate
category based on
clinical context.
769
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C40.23 Alcohol dependence, sustained partial
remission
F10.24 Mental and behavioural disorders due to use
of alcohol: dependence syndrome, currently using the
substance [active dependence]
4-character code: F10.2 Mental and behavioural disorders
due to use of alcohol: dependence syndrome
6C40.24 Alcohol dependence, sustained full
remission
F10.20 Mental and behavioural disorders due to use of
alcohol: dependence syndrome, currently abstinent
4-character code: F10.2 Mental and behavioural disorders
due to use of alcohol: dependence syndrome
6C40.2Z Alcohol dependence, unspecified
F10.2 Mental and behavioural disorders due to use of alcohol:
dependence syndrome
6C40.3 Alcohol intoxication
F10.0 Mental and behavioural disorders due to use of alcohol:
acute intoxication
6C40.4 Alcohol withdrawal
F10.3 Mental and behavioural disorders due to use of alcohol
withdrawal state
6C40.40 Alcohol withdrawal, uncomplicated
F10.30 Mental and behavioural disorders due to use of alcohol
withdrawal state, uncomplicated
4-character code: F10.3 Mental and behavioural disorders
due to use of alcohol withdrawal state
6C40.41 Alcohol withdrawal with perceptual
disturbances
F10.3 Mental and behavioural disorders due to use of alcohol
withdrawal state
6C40.42 Alcohol withdrawal with seizures
F10.31 Mental and behavioural disorders due to use of alcohol
withdrawal state, with convulsions
4-character code: F10.3 Mental and behavioural disorders
due to use of alcohol withdrawal state
6C40.43 Alcohol withdrawal with perceptual
disturbances and seizures
F10.31 Mental and behavioural disorders due to use of alcohol
withdrawal state, with convulsions
4-character code: F10.3 Mental and behavioural disorders
due to use of alcohol withdrawal state
6C40.4Z Alcohol withdrawal, unspecified
F10.3 Mental and behavioural disorders due to use of alcohol
withdrawal state
6C40.5 Alcohol-induced delirium
F10.03 Mental and behavioural disorders due to use of
alcohol: acute intoxication with delirium
4-character code: F10.0 Mental and behavioural disorders
due to use of alcohol: acute intoxication
OR
F10.4 Mental and behavioural disorders due to use of alcohol
withdrawal state with delirium
OR
F10.8 Mental and behavioural disorders due to use of alcohol:
other mental and behavioural disorders
Use F10.8 if intoxication/
withdrawal status is
unknown.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C40.6 Alcohol-induced psychotic disorder
F10.5 Mental and behavioural disorders due to use of alcohol:
psychotic disorder
6C40.60 Alcohol-induced psychotic disorder with
hallucinations
F10.52 Mental and behavioural disorders due to use of
alcohol: psychotic disorder, predominantly hallucinatory
(includes alcoholic hallucinosis)
4-character code: F10.5 Mental and behavioural disorders
due to use of alcohol: psychotic disorder
6C40.61 Alcohol-induced psychotic disorder with
delusions
F10.51 Mental and behavioural disorders due to use of
alcohol: psychotic disorder, predominantly delusional
4-character code: F10.5 Mental and behavioural disorders
due to use of alcohol: psychotic disorder
6C40.62 Alcohol-induced psychotic disorder with
mixed psychotic symptoms
F10.56 Mental and behavioural disorders due to use of
alcohol: psychotic disorder, mixed
4-character code: F10.5 Mental and behavioural disorders
due to use of alcohol: psychotic disorder
6C40.6Z Alcohol-induced psychotic disorder,
unspecified
F10.5 Mental and behavioural disorders due to use of alcohol:
psychotic disorder
6C40.70 Alcohol-induced mood disorder
F10.8 Mental and behavioural disorders due to use of alcohol:
other mental and behavioural disorders
6C40.71 Alcohol-induced anxiety disorder
F10.8 Mental and behavioural disorders due to use of alcohol:
other mental and behavioural disorders
6C40.Y Other specified disorder due to use of alcohol
F10.8 Mental and behavioural disorders due to use of alcohol:
other mental and behavioural disorders
6C40.Z Disorder due to use of alcohol, unspecified
F10.9 Mental and behavioural disorders due to use of alcohol:
unspecified mental and behavioural disorder
6C41 Disorders due to use of cannabis
F12 Mental and behavioural disorders due to use of
cannabinoids
6C41.0 Episode of harmful use of cannabis
F12.8 Mental and behavioural disorders due to use of
cannabinoids: other mental and behavioural disorders
6C41.1 Harmful pattern of use of cannabis
F12.1 Mental and behavioural disorders due to use of
cannabinoids: harmful use
6C41.10 Harmful pattern of use of cannabis, episodic
F12.1 Mental and behavioural disorders due to use of
cannabinoids: harmful use
6C41.11 Harmful pattern of use of cannabis,
continuous
F12.1 Mental and behavioural disorders due to use of
cannabinoids: harmful use
6C41.1Z Harmful pattern of use of cannabis,
unspecified
F12.1 Mental and behavioural disorders due to use of
cannabinoids: harmful use
6C41.2 Cannabis dependence
F12.2 Mental and behavioural disorders due to use of
cannabinoids: dependence syndrome
771
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C41.20 Cannabis dependence, current use
F12.24 Mental and behavioural disorders due to use of
cannabinoids: dependence syndrome, currently using the
substance [active dependence]
4-character code: F12.2 Mental Behavioural disorders due to
use of cannabinoids: dependence syndrome
6C41.21 Cannabis dependence, early full remission
F12.20 Mental and behavioural disorders due to use of
cannabinoids: dependence syndrome, currently abstinent
OR
F12.21 Mental and behavioural disorders due to use of
cannabinoids: dependence syndrome, currently abstinent but
in a protected environment
4-character code: F12.2 Mental and behavioural disorders
due to use of cannabinoids: dependence syndrome
Select the appropriate
category based on
clinical context.
6C41.22 Cannabis dependence, sustained partial
remission
F12.24 Mental and behavioural disorders due to use of
cannabinoids: dependence syndrome, currently using the
substance [active dependence]
4-character code: F12.2 Mental and behavioural disorders
due to use of cannabinoids: dependence syndrome
6C41.23 Cannabis dependence, sustained full
remission
F12.20 Mental and behavioural disorders due to use of
cannabinoids: dependence syndrome, currently abstinent
4-character code: F12.2 Mental and behavioural disorders
due to use of cannabinoids: dependence syndrome
6C41.2Z Cannabis dependence, unspecified
F12.9 Mental and behavioural disorders due to use of
cannabinoids: unspecified mental and behavioural disorder
6C41.3 Cannabis intoxication
F12.0 Mental and behavioural disorders due to use of
cannabinoids: acute intoxication
6C41.4 Cannabis withdrawal
F12.3 Mental and behavioural disorders due to use of
cannabinoids withdrawal state
6C41.5 Cannabis-induced delirium
F12.03 Mental and behavioural disorders due to use of
cannabinoids: acute intoxication with delirium
4-character code: F12.0 Mental and behavioural disorders
due to use of cannabinoids: acute intoxication
OR
F12.4 Mental and behavioural disorders due to use of
cannabinoids withdrawal state with delirium
OR
F12.8 Mental and behavioural disorders due to use of
cannabinoids: other mental and behavioural disorders
Use F12.8 if intoxication/
withdrawal status is
unknown.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C41.6 Cannabis-induced psychotic disorder
F12.5 Mental and behavioural disorders due to use of
cannabinoids: psychotic disorder
6C41.70 Cannabis-induced mood disorder
F12.8 Mental and behavioural disorders due to use of
cannabinoids: other mental and behavioural disorders
6C41.71 Cannabis-induced anxiety disorder
F12.8 Mental and behavioural disorders due to use of
cannabinoids: other mental and behavioural disorders
6C41.Y Other specified disorder due to use of cannabis
F12.8 Mental and behavioural disorders due to use of
cannabinoids: other mental and behavioural disorders
6C41.Z Disorder due to use of cannabis, unspecified
F12.9 Mental and behavioural disorders due to use of
cannabinoids: unspecified mental and behavioural disorder
6C42 Disorders due to use of synthetic
cannabinoids
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C42.0 Episode of harmful use of synthetic
cannabinoids
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C42.1 Harmful pattern of use of synthetic
cannabinoids
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C42.10 Harmful pattern of use of synthetic
cannabinoids, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C42.11 Harmful pattern of use of synthetic
cannabinoids, continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C42.1Z Harmful pattern of use of synthetic
cannabinoids, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C42.2 Synthetic cannabinoid dependence
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C42.20 Synthetic cannabinoid dependence, current
use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C42.21 Synthetic cannabinoid dependence, early
full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
6C42.22 Synthetic cannabinoid dependence,
sustained partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
773
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C42.23 Synthetic cannabinoid dependence,
sustained full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C42.2Z Synthetic cannabinoid dependence,
unspecified
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C42.3 Synthetic cannabinoid intoxication
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication
6C42.4 Synthetic cannabinoid withdrawal
F19.3 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state
6C42.5 Synthetic cannabinoid-induced delirium
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
Use F19.8 if intoxication/
withdrawal status is
unknown.
6C42.6 Synthetic cannabinoid-induced psychotic
disorder
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
6C42.70 Synthetic cannabinoid-induced mood
disorder
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C42.71 Synthetic cannabinoid-induced anxiety
disorder
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C42.Y Other specified disorder due to use of
synthetic cannabinoids
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C42.Z Disorder due to use of synthetic cannabinoids,
unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C43 Disorders due to use of opioids
F11 Mental and behavioural disorders due to use of opioids
6C43.0 Episode of harmful use of opioids
F11.8 Mental and behavioural disorders due to use of opioids:
other mental and behavioural disorders
6C43.1 Harmful pattern of use of opioids
F11.1 Mental and behavioural disorders due to use of opioids:
harmful use
6C43.10 Harmful pattern of use of opioids, episodic
F11.1 Mental and behavioural disorders due to use of opioids:
harmful use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C43.11 Harmful pattern of use of opioids, continuous
F11.1 Mental and behavioural disorders due to use of opioids:
harmful use
6C43.1Z Harmful pattern of use of opioids,
unspecified
F11.1 Mental and behavioural disorders due to use of opioids:
harmful use
6C43.2 Opioid dependence
F11.2 Mental and behavioural disorders due to use of opioids:
dependence syndrome
6C43.20 Opioid dependence, current use
F11.24 Mental and behavioural disorders due to use
of opioids: dependence syndrome, currently using the
substance [active dependence]
4-character code: F11.2 Mental and behavioural disorders due
to use of opioids: dependence syndrome
6C43.21 Opioid dependence, early full remission
F11.20 Mental and behavioural disorders due to use of
opioids: dependence syndrome, currently abstinent
OR
F11.21 Mental and behavioural disorders due to use of opioids:
dependence syndrome, currently abstinent, but in a protected
environment
OR
F11.23 Mental and behavioural disorders due to use of
opioids: dependence syndrome, currently abstinent, but
receiving treatment with aversive or blocking drugs (e.g.
naltrexone or disulfiram)
4-character code: F11.2 Mental and behavioural disorders due
to use of opioids: dependence syndrome
Select the appropriate
category based on
clinical context.
6C43.22 Opioid dependence, sustained partial
remission
F11.24 Mental and behavioural disorders due to use
of opioids: dependence syndrome, currently using the
substance [active dependence]
4-character code: F11.2 Mental and behavioural disorders due
to use of opioids: dependence syndrome
6C43.23 Opioid dependence, sustained full remission
F11.20 Mental and behavioural disorders due to use of
opioids: dependence syndrome, currently abstinent
4-character code: F11.2 Mental and behavioural disorders due
to use of opioids: dependence syndrome
6C43.2Z Opioid dependence, unspecified
F11.2 Mental and behavioural disorders due to use of opioids:
dependence syndrome
6C43.3 Opioid intoxication
F11.0 Mental and behavioural disorders due to use of opioids:
acute intoxication
6C43.4 Opioid withdrawal
F11.3 Mental and behavioural disorders due to use of opioids
withdrawal state
775
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C43.5 Opioid-induced delirium
F11.03 Mental and behavioural disorders due to use of
opioids: acute intoxication with delirium
4-character code: F11.0 Mental and behavioural disorders due
to use of opioids: acute intoxication
OR
F11.4 Mental and behavioural disorders due to use of opioids
withdrawal state with delirium
OR
F11.8 Mental and behavioural disorders due to use of opioids:
other mental and behavioural disorders
Use F11.8 if intoxication/
withdrawal status is
unknown.
6C43.6 Opioid-induced psychotic disorder
F11.5 Mental and behavioural disorders due to use of opioids:
psychotic disorder
6C43.70 Opioid-induced mood disorder
F11.8 Mental and behavioural disorders due to use of opioids:
other mental and behavioural disorders
6C43.71 Opioid-induced anxiety disorder
F11.8 Mental and behavioural disorders due to use of opioids:
other mental and behavioural disorders
6C43.Y Other specified disorder due to use of opioids
F11.8 Mental and behavioural disorders due to use of opioids:
other mental and behavioural disorders
6C43.Z Disorder due to use of opioids, unspecified
F11.9 Mental and behavioural disorders due to use of opioids:
unspecified mental and behavioural disorder
6C44 Disorders due to use of sedatives, hypnotics
or anxiolytics
F13 Mental and behavioural disorders due to use of sedatives
or hypnotics
6C44.0 Episode of harmful use of sedatives, hypnotics
or anxiolytics
F13.8 Mental and behavioural disorders due to use of
sedatives or hypnotics: other mental and behavioural
disorders
6C44.1 Harmful pattern of use of sedatives, hypnotics
or anxiolytics
F13.1 Mental and behavioural disorders due to use of
sedatives or hypnotics: harmful use
6C44.10 Harmful pattern of use of sedatives,
hypnotics or anxiolytics, episodic
F13.1 Mental and behavioural disorders due to use of
sedatives or hypnotics: harmful use
6C44.11 Harmful pattern of use of sedatives,
hypnotics or anxiolytics, continuous
F13.1 Mental and behavioural disorders due to use of
sedatives or hypnotics: harmful use
6C44.1Z Harmful pattern of use of sedatives,
hypnotics or anxiolytics, unspecified
F13.1 Mental and behavioural disorders due to use of
sedatives or hypnotics: harmful use
6C44.2 Sedative, hypnotic or anxiolytic dependence
F13.2 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome
6C44.20 Sedative, hypnotic or anxiolytic
dependence, current use
F13.24 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome, currently
using the substance [active dependence]
4-character code: F13.2 Mental and behavioural disorders
due to use of sedatives or hypnotics: dependence syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C44.21 Sedative, hypnotic or anxiolytic
dependence, early full remission
F13.20 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome, currently
abstinent
OR
F13.21 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome, currently
abstinent, but in a protected environment
4-character code: F13.2 Mental and behavioural disorders
due to use of sedatives or hypnotics: dependence syndrome
Select the appropriate
category based on
clinical context.
6C44.22 Sedative, hypnotic or anxiolytic
dependence, sustained partial remission
F13.24 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome, currently
using the substance [active dependence]
4-character code: F13.2 Mental and behavioural disorders
due to use of sedatives or hypnotics: dependence syndrome
6C44.23 Sedative, hypnotic or anxiolytic
dependence, sustained full remission
F13.20 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome, currently
abstinent
4-character code: F13.2 Mental and behavioural disorders
due to use of sedatives or hypnotics: dependence syndrome
6C44.2Z Sedative, hypnotic or anxiolytic
dependence, unspecified
F13.2 Mental and behavioural disorders due to use of
sedatives or hypnotics: dependence syndrome
6C44.3 Sedative, hypnotic or anxiolytic intoxication
F13.0 Mental and behavioural disorders due to use of
sedatives or hypnotics: acute intoxication
6C44.4 Sedative, hypnotic or anxiolytic withdrawal
F13.3 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state
6C44.40 Sedative, hypnotic or anxiolytic withdrawal,
uncomplicated
F13.30 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state, uncomplicated
4-character code: F13.3 Mental and behavioural disorders
due to use of sedatives or hypnotics withdrawal state
6C44.41 Sedative, hypnotic or anxiolytic withdrawal,
with perceptual disturbances
F13.3 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state
6C44.42 Sedative, hypnotic or anxiolytic withdrawal,
with seizures
F13.31 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state, with convulsions
4-character code: F13.3 Mental and behavioural disorders
due to use of sedatives or hypnotics withdrawal state
6C44.43 Sedative, hypnotic or anxiolytic withdrawal,
with perceptual disturbances and seizures
F13.31 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state, with convulsions
4-character code: F13.3 Mental and behavioural disorders
due to use of sedatives or hypnotics withdrawal state
6C44.4Z Sedative, hypnotic or anxiolytic withdrawal,
unspecified
F13.3 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state
777
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C44.5 Sedative, hypnotic or anxiolytic-induced
delirium
F13.03 Mental and behavioural disorders due to use of
sedatives or hypnotics: acute intoxication with delirium
4-character code: F13.0 Mental and behavioural disorders
due to use of sedatives or hypnotics: acute intoxication
OR
F13.4 Mental and behavioural disorders due to use of
sedatives or hypnotics withdrawal state with delirium
OR
F13.8 Mental or behavioural disorders due to use of sedatives
or hypnotics: other mental and behavioural disorders
Use F13.8 if intoxication/
withdrawal status is
unknown.
6C44.6 Sedative, hypnotic or anxiolytic-induced
psychotic disorder
F13.5 Mental and behavioural disorders due to use of
sedatives or hypnotics: psychotic disorder
6C44.70 Sedative, hypnotic or anxiolytic-induced
mood disorder
F13.8 Mental and behavioural disorders due to use of
sedatives or hypnotics: other mental and behavioural
disorders
6C44.71 Sedative, hypnotic or anxiolytic-induced
anxiety disorder
F13.8 Mental and behavioural disorders due to use of
sedatives or hypnotics: other mental and behavioural
disorders
6C44.Y Other specified disorder due to use of
sedatives, hypnotics or anxiolytics
F13.8 Mental and behavioural disorders due to use of
sedatives or hypnotics: other mental and behavioural
disorders
6C44.Z Disorder due to use of sedatives, hypnotics or
anxiolytics, unspecified
F13.9 Mental and behavioural disorders due to use of
sedatives or hypnotics: unspecified mental and behavioural
disorder
6C45 Disorders due to use of cocaine
F14 Mental and behavioural disorders due to use of cocaine
6C45.0 Episode of harmful use of cocaine
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
6C45.1 Harmful pattern of use of cocaine
F14.1 Mental and behavioural disorders due to use of cocaine:
harmful use
6C45.10 Harmful pattern of use of cocaine, episodic
F14.1 Mental and behavioural disorders due to use of cocaine:
harmful use
6C45.11 Harmful pattern of use of cocaine,
continuous
F14.1 Mental and behavioural disorders due to use of cocaine:
harmful use
6C45.1Z Harmful pattern of use of cocaine,
unspecified
F 14.1 Mental and behavioural disorders due to use of cocaine:
harmful use
6C45.2 Cocaine dependence
F14.2 Mental and behavioural disorders due to use of cocaine:
dependence syndrome
6C45.20 Cocaine dependence, current use
F14.24 Mental and behavioural disorders due to use of
cocaine: dependence syndrome, currently using the
substance [active dependence]
4-character code: F14.2 Mental and behavioural disorders
due to use of cocaine: dependence syndrome
6C45.21 Cocaine dependence, early full remission
F14.20 Mental and behavioural disorders due to use of
cocaine: dependence syndrome, currently abstinent
OR
F14.21 Mental and behavioural disorders due to use of
cocaine: dependence syndrome, currently abstinent, but in a
protected environment
4-character code: F14.2 Mental and behavioural disorders
due to use of cocaine: dependence syndrome
Select the appropriate
category based on
clinical context.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C45.22 Cocaine dependence, sustained partial
remission
F14.23 Mental and behavioural disorders due to use of
cocaine: dependence syndrome, currently using the
substance [active dependence]
4-character code: F14.2 Mental and behavioural disorders
due to use of cocaine: dependence syndrome
6C45.23 Cocaine dependence, sustained full
remission
F14.20 Mental and behavioural disorders due to use of
cocaine: dependence syndrome, currently abstinent
4-character code: F14.2 Mental and behavioural disorders
due to use of cocaine: dependence syndrome
6C45.2Z Cocaine dependence, unspecified
F14.2 Mental and behavioural disorders due to use of cocaine:
dependence syndrome
6C45.3 Cocaine intoxication
F14.0 Mental and behavioural disorders due to use of cocaine:
acute intoxication
6C45.4 Cocaine withdrawal
F14.3 Mental and behavioural disorders due to use of cocaine
withdrawal state
6C45.5 Cocaine-induced delirium
F14.03 Mental and behavioural disorders due to use of
cocaine: acute intoxication with delirium
4-character code: F14.0 Mental and behavioural disorders
due to use of cocaine: acute intoxication
OR
F14.4 Mental and behavioural disorders due to use of cocaine
withdrawal state with delirium
OR
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
Use F14.8 if intoxication/
withdrawal status is
unknown.
6C45.6 Cocaine-induced psychotic disorder
F14.5 Mental and behavioural disorders due to use of cocaine:
psychotic disorder
6C45.60 Cocaine-induced psychotic disorder with
hallucinations
F14.52 Mental and behavioural disorders due to use of
cocaine: psychotic disorder, predominantly hallucinatory
4-character code: F14.5 Mental and behavioural disorders
due to use of cocaine: psychotic disorder
6C45.61 Cocaine-induced psychotic disorder with
delusions
F14.51 Mental and behavioural disorders due to use of
cocaine: psychotic disorder, predominantly delusional
4-character code: F14.5 Mental and behavioural disorders
due to use of cocaine: psychotic disorder
6C45.62 Cocaine-induced psychotic disorder with
mixed psychotic symptoms
F14.56 Mental and behavioural disorders due to use of
cocaine: psychotic disorder, mixed
4-character code: F14.5 Mental and behavioural disorders
due to use of cocaine: psychotic disorder
779
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C45.6Z Cocaine-induced psychotic disorder,
unspecified
F14.5 Mental and behavioural disorders due to use of cocaine:
psychotic disorder
6C45.70 Cocaine-induced mood disorder
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
6C45.71 Cocaine-induced anxiety disorder
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
6C45.72 Cocaine-induced obsessive-compulsive or
related disorder
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
6C45.73 Cocaine-induced impulse control disorder
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
6C45.Y Other specified disorder due to use of cocaine
F14.8 Mental and behavioural disorders due to use of cocaine:
other mental and behavioural disorders
6C45.Z Disorder due to use of cocaine, unspecified
F14.9 Mental and behavioural disorders due to use of cocaine:
unspecified mental and behavioural disorder
6C46 Disorders due to use of stimulants, including
amfetamines, methamfetamine and methcathinone
F15 Mental and behavioural disorders due to use of other
stimulants, including caffeine
6C46.0 Episode of harmful use of stimulants, including
amfetamines, methamfetamine and methcathinone
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C46.1 Harmful pattern of use of stimulants, including
amfetamines, methamfetamine and methcathinone
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C46.10 Harmful pattern of use of stimulants,
including amfetamines, methamfetamine and
methcathinone, episodic
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C46.11 Harmful pattern of use of stimulants,
including amfetamines, methamfetamine and
methcathinone, continuous
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C46.1Z Harmful pattern of use of stimulants,
including amfetamines, methamfetamine and
methcathinone, unspecified
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C46.2 Stimulant dependence, including amfetamines,
methamfetamine and methcathinone
F15.2 Mental and behavioural disorders due to use of other
stimulants, including caffeine: dependence syndrome
6C46.20 Stimulant dependence, including
amfetamines, methamfetamine and methcathinone,
current use
F15.24 Mental and behavioural disorders due to use of
other stimulants, including caffeine: dependence syndrome,
currently using the substance [active substance]
4-character code: F15.2 Mental and behavioural disorders
due to use of other stimulants, including caffeine:
dependence syndrome
6C46.21 Stimulant dependence, including
amfetamines, methamfetamine and methcathinone,
early full remission
F15.20 Mental and behavioural disorders due to use of
other stimulants, including caffeine: dependence syndrome,
currently abstinent
OR
F15.21 Mental and behavioural disorders due to use of
other stimulants, including caffeine: dependence syndrome,
currently abstinent, but in a protected environment
4-character code: F15.2 Mental and behavioural disorders
due to use of other stimulants, including caffeine:
dependence syndrome
Select the appropriate
category based on
clinical context.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C46.22 Stimulant dependence, including
amfetamines, methamfetamine and methcathinone,
sustained partial remission
F15.24 Mental and behavioural disorders due to use of
other stimulants, including caffeine: dependence syndrome,
currently using the substance [active dependence]
4-character code: F15.2 Mental and behavioural disorders
due to use of other stimulants, including caffeine:
dependence syndrome
6C46.23 Stimulant dependence, including
amfetamines, methamfetamine and methcathinone,
sustained full remission
F15.20 Mental and behavioural disorders due to use of
other stimulants, including caffeine: dependence syndrome,
currently abstinent
4-character code: F15.2 Mental and behavioural disorders
due to use of other stimulants, including caffeine:
dependence syndrome
6C46.2Z Stimulant dependence, including
amfetamines, methamfetamine and methcathinone,
unspecified
F15.9 Mental and behavioural disorders due to use of other
stimulants, including caffeine: unspecified mental and
behavioural disorder
6C46.3 Stimulant intoxication, including amfetamines,
methamfetamine and methcathinone
F15.0 Mental and behavioural disorders due to use of other
stimulants, including caffeine: acute intoxication
6C46.4 Stimulant withdrawal, including amfetamines,
methamfetamine and methcathinone
F15.3 Mental and behavioural disorders due to use of other
stimulants, including caffeine withdrawal state
6C46.5 Stimulant-induced delirium, including
amfetamines, methamfetamine and methcathinone
F15.03 Mental and behavioural disorders due to use of other
stimulants, including caffeine: acute intoxication with delirium
4-character code: F15.0 Mental and behavioural disorders
due to use of other stimulants, including caffeine: acute
intoxication
OR
F15.4 Mental and behavioural disorders due to use of other
stimulants, including caffeine withdrawal state with delirium
OR
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
Use F15.8 if intoxication/
withdrawal status is
unknown.
6C46.6 Stimulant-induced psychotic disorder,
including amfetamines, methamfetamine and
methcathinone
F15.5 Mental and behavioural disorders due to use of other
stimulants, including caffeine: psychotic disorder
6C46.60 Stimulant-induced psychotic disorder,
including amfetamines, methamfetamine and
methcathinone with hallucinations
F15.52 Mental and behavioural disorders due to use of
other stimulants, including caffeine: psychotic disorder,
predominantly hallucinatory
4-character code: F15.5 Mental and behavioural disorders
due to use of other stimulants, including caffeine: other
mental and behavioural disorders
6C46.61 Stimulant-induced psychotic disorder,
including amfetamines, methamfetamine and
methcathinone with delusions
F15.51 Mental and behavioural disorders due to use of
other stimulants, including caffeine: psychotic disorder,
predominantly delusional
4-character code: F15.5 Mental and behavioural disorders
due to use of other stimulants, including caffeine: other
mental and behavioural disorders
781
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C46.62 Stimulant-induced psychotic disorder,
including amfetamines, methamfetamine and
methcathinone with mixed psychotic symptoms
F15.56 Mental and behavioural disorders due to use of other
stimulants, including caffeine: psychotic disorder, mixed
4-character code: F15.5 Mental and behavioural disorders
due to use of other stimulants, including caffeine: other
mental and behavioural disorders
6C46.6Z Stimulant-induced psychotic disorder,
including amfetamines, methamfetamine and
methcathinone, unspecified
F15.5 Mental and behavioural disorders due to use of other
stimulants, including caffeine: psychotic disorder
6C46.70 Stimulant-induced mood disorder, including
amfetamines, methamfetamine and methcathinone
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C46.71 Stimulant-induced anxiety disorder,
including amfetamines, methamfetamine and
methcathinone
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C46.72 Stimulant-induced obsessive-compulsive
or related disorder, including amfetamines,
methamfetamine and methcathinone
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C46.73 Stimulant-induced impulse control disorder,
including amfetamines, methamfetamine and
methcathinone
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C46.Y Other specified disorder due to use of
stimulants, including amfetamines, methamfetamine
and methcathinone
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C46.Z Disorder due to use of stimulants, including
amfetamines, methamfetamine and methcathinone,
unspecified
F15.9 Mental and behavioural disorders due to use of other
stimulants, including caffeine: unspecified mental and
behavioural disorder
6C47 Disorders due to use of synthetic cathinones
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C47.0 Episode of harmful use of synthetic cathinones
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.1 Harmful pattern of use of synthetic cathinones
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C47.10 Harmful pattern of use of synthetic
cathinones, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C47.11 Harmful use of synthetic cathinones,
continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C47.1Z Harmful pattern of use of synthetic
cathinones, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C47.2 Synthetic cathinone dependence
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C47.20 Synthetic cathinone dependence, current
use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C47.21 Synthetic cathinone dependence, early full
remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
6C47.22 Synthetic cathinone dependence, sustained
partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C47.23 Synthetic cathinone dependence, sustained
full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C47.2Z Synthetic cathinone dependence,
unspecified
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C47.3 Synthetic cathinone intoxication
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
acute intoxication
6C47.4 Synthetic cathinone withdrawal
F19.3 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
withdrawal state
Use F19.8 if intoxication/
withdrawal status
is unknown.
6C47.5 Synthetic cathinone-induced delirium
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.6 Synthetic cathinone-induced psychotic
disorder
F19.5 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
psychotic disorder
783
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C47.60 Synthetic cathinone-induced psychotic
disorder with hallucinations
F19.52 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder, predominantly hallucinatory
4-character code: F19.5 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: psychotic disorder
6C47.61 Synthetic cathinone-induced psychotic
disorder with delusions
F19.51 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder, predominantly delusional
4-character code: F19.5 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: psychotic disorder
6C47.62 Synthetic cathinone-induced psychotic
disorder with mixed psychotic symptoms
F19.56 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder, mixed
4-character code: F19.5 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: psychotic disorder
6C47.6Z Synthetic cathinone-induced psychotic
disorder, unspecified
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
6C47.70 Synthetic cathinone-induced mood disorder
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.71 Synthetic cathinone-induced anxiety
disorder
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.72 Synthetic cathinone-induced obsessivecompulsive or related syndrome
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.73 Synthetic cathinone-induced impulse control
disorder
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.Y Other specified disorder due to use of synthetic
cathinones
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C47.Z Disorder due to use of synthetic cathinones,
unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C48 Disorders due to use of caffeine
F15 Mental and behavioural disorders due to use of other
stimulants, including caffeine
6C48.0 Episode of harmful use of caffeine
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C48.1 Harmful pattern of use of caffeine
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C48.10 Harmful pattern of use of caffeine, episodic
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C48.11 Harmful pattern of use of caffeine,
continuous
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C48.1Z Harmful pattern of use of caffeine,
unspecified
F15.1 Mental and behavioural disorders due to use of other
stimulants, including caffeine: harmful use
6C48.2 Caffeine intoxication
F15.0 Mental and behavioural disorders due to use of other
stimulants, including caffeine: acute intoxication
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C48.3 Caffeine withdrawal
F15.3 Mental and behavioural disorders due to use of other
stimulants, including caffeine withdrawal state
6C48.40 Caffeine-induced anxiety disorder
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C48.Y Other specified disorder due to use of caffeine
F15.8 Mental and behavioural disorders due to use of other
stimulants, including caffeine: other mental and behavioural
disorders
6C48.Z Disorder due to use of caffeine, unspecified
F15.9 Mental and behavioural disorders due to use of other
stimulants, including caffeine: unspecified mental and
behavioural disorder
6C49 Disorders due to use of hallucinogens
F16 Mental and behavioural disorders due to use of
hallucinogens
6C49.0 Episode of harmful use of hallucinogens
F16.8 Mental and behavioural disorders due to use of
hallucinogens: other mental and behavioural disorders
6C49.1 Harmful pattern of use of hallucinogens
F16.1 Mental and behavioural disorders due to use of
hallucinogens: harmful use
6C49.10 Harmful pattern of use of hallucinogens,
episodic
F16.1 Mental and behavioural disorders due to use of
hallucinogens: harmful use
6C49.11 Harmful pattern of use of hallucinogens,
continuous
F16.1 Mental and behavioural disorders due to use of
hallucinogens: harmful use
6C49.1Z Harmful pattern of use of hallucinogens,
unspecified
F16.1 Mental and behavioural disorders due to use of
hallucinogens: harmful use
6C49.2 Hallucinogen dependence
F16.2 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome
6C49.20 Hallucinogen dependence, current use
F16.24 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome, currently using the
substance [active dependence]
4-character code: F16.2 Mental and behavioural disorders
due to use of hallucinogens: dependence syndrome
6C49.21 Hallucinogen dependence, early full
remission
F16.20 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome, currently abstinent
OR
F16.21 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome, currently abstinent,
but in a protected environment
4-character code: F16.2 Mental and behavioural disorders
due to use of hallucinogens: dependence syndrome
Select the appropriate
category based on
clinical context.
6C49.22 Hallucinogen dependence, sustained partial
remission
F16.24 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome, currently using the
substance [active dependence]
4-character code: F16.2 Mental and behavioural disorders
due to use of hallucinogens: dependence syndrome
6C49.23 Hallucinogen dependence, sustained full
remission
F16.20 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome, currently abstinent
4-character code: F16.2 Mental and behavioural disorders
due to use of hallucinogens: dependence syndrome
785
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C49.2Z Hallucinogen dependence, unspecified
F16.2 Mental and behavioural disorders due to use of
hallucinogens: dependence syndrome
6C49.3 Hallucinogen intoxication
F16.0 Mental and behavioural disorders due to use of
hallucinogens: acute intoxication
6C49.4 Hallucinogen-induced delirium
F16.03 Mental and behavioural disorders due to use of
hallucinogens: acute intoxication with delirium
4-character code: F16.0 Mental and behavioural disorders
due to use of hallucinogens: acute intoxication
OR
F16.8 Mental and behavioural disorders due to use of
hallucinogens: other mental and behavioural disorders
Use F16.8 if intoxication
status is unknown.
6C49.5 Hallucinogen-induced psychotic disorder
F16.5 Mental and behavioural disorders due to use of
hallucinogens: psychotic disorder
6C49.60 Hallucinogen-induced mood disorder
F16.8 Mental and behavioural disorders due to use of
hallucinogens: other mental and behavioural disorders
6C49.61 Hallucinogen-induced anxiety disorder
F16.8 Mental and behavioural disorders due to use of
hallucinogens: other mental and behavioural disorders
6C49.Y Other specified disorder due to use of
hallucinogens
F16.8 Mental and behavioural disorders due to use of
hallucinogens: other mental and behavioural disorders
6C49.Z Disorder due to use of hallucinogens,
unspecified
F16.9 Mental and behavioural disorders due to use of
hallucinogens: unspecified mental and behavioural disorder
6C4A Disorders due to use of nicotine
F17 Mental and behavioural disorders due to use of tobacco
6C4A.0 Episode of harmful use of nicotine
F17.8 Mental and behavioural disorders due to use of tobacco:
other mental and behavioural disorders
6C4A.1 Harmful pattern of use of nicotine
F17.1 Mental and behavioural disorders due to use of tobacco:
harmful use
6C4A.10 Harmful pattern of use of nicotine, episodic
F17.1 Mental and behavioural disorders due to use of tobacco:
harmful use
6C4A.11 Harmful pattern of use of nicotine,
continuous
F17.1 Mental and behavioural disorders due to use of tobacco:
harmful use
6C4A.1Z Harmful pattern of use of nicotine,
unspecified
F17.1 Mental and behavioural disorders due to use of tobacco:
harmful use
6C4A.2 Nicotine dependence
F17.2 Mental and behavioural disorders due to use of tobacco:
dependence syndrome
6C4A.20 Nicotine dependence, current use
F17.24 Mental and behavioural disorders due to use of
tobacco: dependence syndrome, currently using the
substance [active dependence]
4-character code: F17.2 Mental and behavioural disorders due
to use of tobacco: dependence syndrome
6C4A.21 Nicotine dependence, early full remission
F17.20 Mental and behavioural disorders due to use of
tobacco: dependence syndrome, currently abstinent
OR
F17.21 Mental and behavioural disorders due to use of
tobacco: dependence syndrome, currently abstinent, but in
a protected environment
4-character code: F17.2 Mental and behavioural disorders due
to use of tobacco: dependence syndrome
Select the appropriate
category based on
clinical context.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4A.22 Nicotine dependence, sustained partial
remission
F17.24 Mental and behavioural disorders due to use of
tobacco: dependence syndrome, currently using the
substance [active dependence]
4-character code: F17.2 Mental and behavioural disorders due
to use of tobacco: dependence syndrome
6C4A.23 Nicotine dependence, sustained full
remission
F17.20 Mental and behavioural disorders due to use of
tobacco: dependence syndrome, currently abstinent
4-character code: F17.2 Mental and behavioural disorders due
to use of tobacco: dependence syndrome
6C4A.2Z Nicotine dependence, unspecified
F17.2 Mental and behavioural disorders due to use of tobacco:
dependence syndrome
6C4A.3 Nicotine intoxication
F17.0 Mental and behavioural disorders due to use of tobacco:
acute intoxication
6C4A.4 Nicotine withdrawal
F17.3 Mental and behavioural disorders due to use of tobacco
withdrawal state
6C4A.Y Other specified disorder due to use of nicotine
F17.3 Mental and behavioural disorders due to use of tobacco
withdrawal state
6C4A.Z Disorder due to use of nicotine, unspecified
F17.3 Mental and behavioural disorders due to use of tobacco
withdrawal state
6C4B Disorders due to use of volatile inhalants
F18 Mental and behavioural disorders due to use of volatile
solvents
6C4B.0 Episode of harmful use of volatile inhalants
F18.8 Mental and behavioural disorders due to use of volatile
solvents: other mental and behavioural disorders
6C4B.1 Harmful pattern of use of volatile inhalants
F18.1 Mental and behavioural disorders due to use of volatile
solvents: harmful use
6C4B.10 Harmful pattern of use of volatile inhalants,
episodic
F18.1 Mental and behavioural disorders due to use of volatile
solvents: harmful use
6C4B.11 Harmful pattern of use of volatile inhalants,
continuous
F18.1 Mental and behavioural disorders due to use of volatile
solvents: harmful use
6C4B.1Z Harmful pattern of use of volatile inhalants,
unspecified
F18.1 Mental and behavioural disorders due to use of volatile
solvents: harmful use
6C4B.2 Volatile inhalant dependence
F18.2 Mental and behavioural disorders due to use of volatile
solvents: dependence syndrome
6C4B.20 Volatile inhalant dependence, current use
F18.24 Mental and behavioural disorders due to use of
volatile solvents: dependence syndrome, currently using the
substance [active dependence]
4-character code: F18.2 Mental and behavioural disorders
due to use of volatile solvents: dependence syndrome
6C4B.21 Volatile inhalant dependence, early full
remission
F18.20 Mental and behavioural disorders due to use of volatile
solvents: dependence syndrome, currently abstinent
OR
F18.21 Mental and behavioural disorders due to use of volatile
solvents: dependence syndrome, currently abstinent, but in
a protected environment
4-character code: F18.2 Mental and behavioural disorders
due to use of volatile solvents: dependence syndrome
Select the appropriate
category based on
clinical context.
787
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4B.22 Volatile inhalant dependence, sustained
partial remission
F18.24 Mental and behavioural disorders due to use of
volatile solvents: dependence syndrome, currently using the
substance [active dependence]
4-character code: F18.2 Mental and behavioural disorders
due to use of volatile solvents: dependence syndrome
6C4B.23 Volatile inhalant dependence, sustained full
remission
F18.20 Mental and behavioural disorders due to use of volatile
solvents: dependence syndrome, currently abstinent
4-character code: F18.2 Mental and behavioural disorders
due to use of volatile solvents: dependence syndrome
6C4B.2Z Volatile inhalant dependence, unspecified
F18.2 Mental and behavioural disorders due to use of volatile
solvents: dependence syndrome
6C4B.3 Volatile inhalant intoxication
F18.0 Mental and behavioural disorders due to use of volatile
solvents: acute intoxication
6C4B.4 Volatile inhalant withdrawal
F18.3 Mental and behavioural disorders due to use of volatile
solvents withdrawal state
6C4B.5 Volatile inhalant-induced delirium
F18.03 Mental and behavioural disorders due to use of volatile
solvents: acute intoxication with delirium
4-character code: F18.0 Mental and behavioural disorders
due to use of volatile solvents: acute intoxication
OR
F18.4 Mental and behavioural disorders due to use of volatile
solvents withdrawal state with delirium
OR
F18.8 Mental and behavioural disorders due to use of volatile
solvents: other mental and behavioural disorders
Use F18.8 if intoxication/
withdrawal status is
unknown.
6C4B.6 Volatile inhalant-induced psychotic disorder
F18.5 Mental and behavioural disorders due to use of volatile
solvents: psychotic disorder
6C4B.70 Volatile inhalant-induced mood disorder
F18.8 Mental and behavioural disorders due to use of volatile
solvents: other mental and behavioural disorders
6C4B.71 Volatile inhalant-induced anxiety disorder
F18.8 Mental and behavioural disorders due to use of volatile
solvents: other mental and behavioural disorders
6C4B.Y Other specified disorder due to use of volatile
inhalants
F18.8 Mental and behavioural disorders due to use of volatile
solvents: other mental and behavioural disorders
6C4B.Z Disorder due to use of volatile inhalants,
unspecified
F18.9 Mental and behavioural disorders due to use of volatile
solvents: unspecified mental and behavioural disorder
6C4C Disorders due to use of MDMA or related
drugs, including MDA
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C4C.0 Episode of harmful use of MDMA or related
drugs, including MDA
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4C.1 Harmful pattern of use of MDMA or related
drugs, including MDA
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4C.10 Harmful use of MDMA or related drugs,
including MDA, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4C.11 Harmful use of MDMA or related drugs,
including MDA, continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4C.1Z Harmful pattern of use of MDMA or related
drugs, including MDA, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
us and use of other psychoactive substances: harmful use
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4C.2 MDMA or related drug dependence, including
MDA
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4C.20 MDMA or related drug dependence,
including MDA, current use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4C.21 MDMA or related drug dependence,
including MDA, early full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
6C4C.22 MDMA or related drug dependence,
including MDA, sustained partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4C.23 MDMA or related drug dependence,
including MDA, sustained full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4C.2Z MDMA or related drug dependence,
including MDA, unspecified
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4C.3 MDMA or related drug intoxication, including
MDA
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
acute intoxication
6C4C.4 MDMA or related drug withdrawal, including
MDA
F19.3 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
withdrawal state
789
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4C.5 MDMA or related drug-induced delirium,
including MDA
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
Use F19.8 if intoxication/
withdrawal status
is unknown.
6C4C.6 MDMA or related drug-induced psychotic
disorder, including MDA
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
6C4C.70 MDMA or related drug-induced mood
disorder, including MDA
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4C.71 MDMA or related drug-induced anxiety
disorder
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4C.Y Other specified disorder due to use of MDMA
or related drugs, including MDA
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4C.Z Disorder due to use of MDMA or related drugs,
including MDA, unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C4D Disorders due to use of dissociative drugs,
including ketamine and phencyclidine (PCP)
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C4D.0 Episode of harmful use of dissociative drugs,
including ketamine and PCP
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4D.1 Harmful pattern of use of dissociative drugs,
including ketamine and PCP
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4D.10 Harmful pattern of use of dissociative drugs,
including ketamine and PCP, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4D.11 Harmful pattern of use of dissociative drugs,
including ketamine and PCP, continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4D.1Z Harmful pattern of use of dissociative drugs,
including ketamine and PCP, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4D.2 Dissociative drug dependence, including
ketamine and PCP
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4D.20 Dissociative drug dependence, including
ketamine and PCP, current use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4D.21 Dissociative drug dependence, including
ketamine and PCP, early full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
6C4D.22 Dissociative drug dependence, including
ketamine and PCP, sustained partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4D.23 Dissociative drug dependence, including
ketamine and PCP, sustained full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4D.2Z Dissociative drug dependence, including
ketamine and PCP, unspecified
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4D.3 Dissociative drug intoxication, including
ketamine and PCP
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication
6C4D.4 Dissociative drug-induced delirium, including
ketamine and PCP
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
Use F19.8 if intoxication
status unknown.
6C4D.5 Dissociative drug-induced psychotic disorder,
including ketamine and PCP
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
791
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4D.60 Dissociative drug-induced mood disorder,
including ketamine and PCP
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4D.6 Dissociative drug-induced anxiety disorder,
including ketamine and PCP
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4D.Y Other specified disorder due to use of
dissociative drugs, including ketamine and PCP
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4D.Z Disorder due to use of dissociative drugs,
including ketamine and PCP, unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C4E Disorders due to use of other specified
psychoactive substances, including medications
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C4E.0 Episode of harmful use of other specified
psychoactive substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4E.1 Harmful pattern of use of other specified
psychoactive substance
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4E.10 Harmful pattern of use of other specified
psychoactive substance, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4E.11 Harmful pattern of use of other specified
psychoactive substance, continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4E.1Z Harmful pattern of use of other specified
psychoactive substance, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4E.2 Other specified psychoactive substance
dependence
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4E.20 Other specified psychoactive substance
dependence, current use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4E.21 Other specified psychoactive substance
dependence, early full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
OR
F19.23 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but receiving treatment with
aversive or blocking drugs (e.g. naltrexone or disulfiram)
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4E.22 Other specified psychoactive substance
dependence, sustained partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4E.23 Other specified psychoactive substance
dependence, sustained full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4E.2Z Other specified psychoactive substance
dependence, unspecified
F19.2 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
dependence syndrome
6C4E.3 Other specified psychoactive substance
intoxication
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
acute intoxication
6C4E.4 Other specified psychoactive substance
withdrawal
F19.3 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
withdrawal state
6C4E.40 Other specified psychoactive substance
withdrawal, uncomplicated
F19.30 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, uncomplicated
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4E.41 Other specified psychoactive substance
withdrawal, with perceptual disturbances
F19.3 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
withdrawal state
6C4E.42 Other specified psychoactive substance
withdrawal, with seizures
F19.31 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, with convulsions
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4E.43 Other specified psychoactive substance
withdrawal, with perceptual disturbances and
seizures
F19.31 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, with convulsions
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4E.4Z Other specified psychoactive substance
withdrawal, unspecified
F19.3 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
withdrawal state
793
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4E.5 Delirium induced by other specified
psychoactive substance, including medications
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
Use F19.8 if intoxication/
withdrawal status is
unknown.
6C4E.6 Psychotic disorder induced by other specified
psychoactive substance
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
6C4E.70 Mood disorder induced by other specified
psychoactive substance
F19.8 Mental and behavioural disorder due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4E.71 Anxiety disorder induced by other specified
psychoactive substance
F19.8 Mental and behavioural disorder due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4E.72 Obsessive-compulsive or related disorder
induced by other specified psychoactive substance
F19.8 Mental and behavioural disorder due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4E.73 Impulse control disorder induced by other
specified psychoactive substance
F19.8 Mental and behavioural disorder due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4E.Y Other specified disorder due to use of
other specified psychoactive substance, including
medications
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4E.Z Disorder due to use of other specified
psychoactive substance, including medications,
unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C4F Disorders due to use of multiple specified
psychoactive substances, including medications
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C4F.0 Episode of harmful use of multiple specified
psychoactive substances
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4F.1 Harmful pattern of use of multiple specified
psychoactive substances
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4F.10 Harmful pattern of use of multiple specified
psychoactive substances, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4F.11 Harmful pattern of use of multiple specified
psychoactive substances, continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4F.1Z Harmful pattern of use of multiple specified
psychoactive substances, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4F.2 Multiple specified psychoactive substances
dependence
F19.2 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
dependence syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4F.20 Multiple specified psychoactive substances
dependence, current use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4F.21 Multiple specified psychoactive substances
dependence, early full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
OR
F19.23 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but receiving treatment with
aversive or blocking drugs (e.g. naltrexone or disulfiram)
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
6C4F.22 Multiple specified psychoactive substances
dependence, sustained partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4F.23 Multiple specified psychoactive substances
dependence, sustained full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4F.2Z Multiple specified psychoactive substances
dependence, unspecified
F19.2 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
dependence syndrome
6C4F.3 Intoxication due to multiple specified
psychoactive substances
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances:
acute intoxication
6C4F.4 Multiple specified psychoactive substances
withdrawal
F19.3 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances
withdrawal state
6C4F.40 Multiple specified psychoactive substances
withdrawal, uncomplicated
F19.30 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, uncomplicated
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
795
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4F.41 Multiple specified psychoactive substances
withdrawal, with perceptual disturbances
F19.3 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state
6C4F.42 Multiple specified psychoactive substances
withdrawal, with seizures
F19.31 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, with convulsions
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4F.43 Multiple specified psychoactive substances
withdrawal, with perceptual disturbances and
seizures
F19.31 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, with convulsions
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4F.4Y Other specified multiple specified
psychoactive substances withdrawal
F19.3 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state
6C4F.4Z Multiple specified psychoactive substances
withdrawal, unspecified
F19.3 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state
6C4F.5 Delirium induced by multiple specified
psychoactive substances, including medications
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
Use F19.8 if intoxication/
withdrawal status
is unknown.
6C4F.6 Psychotic disorder induced by multiple
specified psychoactive substances
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
6C4F.70 Mood disorder induced by multiple specified
psychoactive substances
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4F.71 Anxiety disorder induced by multiple
specified psychoactive substances
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4F.72 Obsessive-compulsive or related disorder
induced by multiple specified psychoactive
substances
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4F.73 Impulse control syndrome induced by
multiple specified psychoactive substances
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4F.Y Other specified disorder . due to use of
multiple specified psychoactive substances, including
medications
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4F.Z Disorder due to use of multiple specified
psychoactive substances, including medications,
unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C4G Disorders due to use of unknown or
unspecified psychoactive substances
F19 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances
6C4G.0 Episode of harmful use of unknown or
unspecified psychoactive substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4G.1 Harmful pattern of use of unknown or
unspecified psychoactive substance
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4G.10 Harmful pattern of use of unknown or
unspecified psychoactive substance, episodic
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4G.11 Harmful pattern of use of unknown or
unspecified psychoactive substance, continuous
F19.1 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: harmful use
6C4G.1Z Harmful pattern of use of unknown or
unspecified psychoactive substance, unspecified
F19.1 Mental and behavioural disorders due to multiple drug
us and use of other psychoactive substances: harmful use
6C4G.2 Unknown or unspecified psychoactive
substance dependence
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4G.20 Unknown or unspecified psychoactive
substance dependence, current use
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4G.21 Unknown or unspecified psychoactive
substance dependence, early full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
OR
F19.21 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent, but in a protected environment
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
Select the appropriate
category based on
clinical context.
6C4G.22 Unknown or unspecified psychoactive
substance dependence, sustained partial remission
F19.24 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently using the substance [active dependence]
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
6C4G.23 Unknown or unspecified psychoactive
substance dependence, sustained full remission
F19.20 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome, currently abstinent
4-character code: F19.2 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: dependence syndrome
797
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4G.2Z Unknown or unspecified psychoactive
substance dependence, unspecified
F19.2 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: dependence
syndrome
6C4G.3 Intoxication due to unknown or unspecified
psychoactive substance
F19.0 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication
6C4G.4 Withdrawal due to unknown or unspecified
psychoactive substance
F19.3 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state
6C4G.40 Withdrawal due to unknown or unspecified
psychoactive substance, uncomplicated
F19.30 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, uncomplicated
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4G.41 Withdrawal due to unknown or unspecified
psychoactive substance, with perceptual
disturbances
F19.3 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state
6C4G.42 Withdrawal due to unknown or unspecified
psychoactive substance, with seizures
F19.31 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, with convulsions
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4G.43 Withdrawal due to unknown or unspecified
psychoactive substance, with perceptual
disturbances and seizures
F19.31 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state, with convulsions
4-character code: F19.3 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances withdrawal state
6C4G.4Z Withdrawal due to unknown or unspecified
psychoactive substance, unspecified
F19.3 Mental and behavioural disorders due to multiple drug
us and use of other psychoactive substances withdrawal
state
6C4G.5 Delirium induced by unknown or unspecified
psychoactive substance
F19.03 Mental and behavioural disorders due to multiple
drug use and use of other psychoactive substances: acute
intoxication with delirium
4-character code: F19.0 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: acute intoxication
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
OR
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: Other mental
and behavioural disorders
Use F19.8 if intoxication/
withdrawal status
is unknown.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C4G.6 Psychotic disorder induced by unknown or
unspecified psychoactive substance
F19.5 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: psychotic
disorder
6C4G.70 Mood disorder induced by unknown or
unspecified psychoactive substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4G.71 Anxiety disorder induced by unknown or
unspecified psychoactive substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4G.72 Obsessive-compulsive or related disorder
induced by unknown or unspecified psychoactive
substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4G.73 Impulse control disorder induced by
unknown or unspecified psychoactive substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4G.Y Other specified disorder due to use of
unknown or unspecified psychoactive substance
F19.8 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: other mental
and behavioural disorders
6C4G.Z Disorder due to use of unknown or unspecified
psychoactive substance, unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
6C4H Disorders due to use of non-psychoactive
substances
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4H.0 Episode of harmful use of non-psychoactive
substance
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4H.1 Harmful pattern of use of non-psychoactive
substance
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4H.10 Harmful pattern of use of non-psychoactive
substance, episodic
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4H.11 Harmful pattern of use of non-psychoactive
substance, continuous
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4H.1Z Harmful pattern of use of non-psychoactive
substance, unspecified
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4H.Y Other specified disorder due to use of nonpsychoactive substance
F55 Abuse of non-dependence-producing substances
No 4-character code available
799
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C4H.Z Disorder due to use of non-psychoactive
substance, unspecified
F55 Abuse of non-dependence-producing substances
No 4-character code available
6C4Z Disorder due to substance use, unspecified
F19.9 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: unspecified
mental and behavioural disorder
OR
F55 Abuse of non-dependence-producing substance
For non-psychoactive
(i.e. non-dependenceproducing) substances,
use F55.
Disorders due to addictive behaviours
6C50 Gambling disorder
F63.0 Pathological gambling
6C50.0 Gambling disorder, predominantly offline
F63.0 Pathological gambling
6C50.1 Gambling disorder, predominantly online
F63.0 Pathological gambling
6C50.Z Gambling disorder, unspecified
F63.0 Pathological gambling
6C51 Gaming disorder
F63.8 Other habit and impulse disorders
6C51.0 Gaming disorder, predominantly online
F63.8 Other habit and impulse disorders
6C51.1 Gaming disorder, predominantly offline
F63.8 Other habit and impulse disorders
6C51.Z Gaming disorder, unspecified
F63.8 Other habit and impulse disorders
6C5Y Other specified disorder due to addictive
behaviours
F63.8 Other habit and impulse disorders
6C5Z Disorder due to addictive behaviours,
unspecified
F63.9 Habit and impulse disorder, unspecified
Impulse control disorders
6C70 Pyromania
F63.1 Pathological fire setting [pyromania]
6C71 Kleptomania
F63.2 Pathological stealing [kleptomania]
6C72 Compulsive sexual behaviour disorder
F63.8 Other habit and impulse disorders
6C73 Intermittent explosive disorder
F63.8 Other habit and impulse disorders
6C7Y Other specified impulse control disorder
F63.8 Other habit and impulse disorders
6C7Z Impulse control disorder, unspecified
F63.9 Habit and impulse disorder, unspecified
Disruptive behaviour and dissocial disorders
6C90 Oppositional defiant disorder
F91.3 Oppositional defiant disorder
6C90.0 Oppositional defiant disorder with chronic
irritability-anger
F91.3 Oppositional defiant disorder
6C90.00 Oppositional defiant disorder with chronic
irritability-anger with limited prosocial emotions
F91.3 Oppositional defiant disorder
6C90.01 Oppositional defiant disorder with chronic
irritability-anger with typical prosocial emotions
F91.3 Oppositional defiant disorder
6C90.0Z Oppositional defiant disorder with chronic
irritability-anger, unspecified
F91.3 Oppositional defiant disorder
6C90.1 Oppositional defiant disorder without chronic
irritability-anger
F91.3 Oppositional defiant disorder
C90.10 Oppositional defiant disorder without chronic
irritability-anger with limited prosocial emotions
F91.3 Oppositional defiant disorder
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6C90.11 Oppositional defiant disorder without chronic
irritability-anger with typical prosocial emotions
F91.3 Oppositional defiant disorder
6C90.1Z Oppositional defiant disorder without
chronic irritability-anger, unspecified
F91.3 Oppositional defiant disorder
6C90.Z Oppositional defiant disorder, unspecified
F91.3 Oppositional defiant disorder
6C91 Conduct-dissocial disorder
F91 Conduct disorders
4-character code: F91.9 Conduct disorder, unspecified
6C91.0 Conduct-dissocial disorder, childhood onset
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.00 Conduct-dissocial disorder, childhood onset
with limited prosocial emotions
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.01 Conduct-dissocial disorder, childhood onset
with typical prosocial emotions
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.0Z Conduct-dissocial disorder, childhood onset,
unspecified
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.1 Conduct-dissocial disorder, adolescent onset
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.10 Conduct-dissocial disorder, adolescent onset
with limited prosocial emotions
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.11 Conduct-dissocial disorder, adolescent onset
with typical prosocial emotions
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.1Z Conduct-dissocial disorder, adolescent
onset, unspecified
F91 Conduct disorders
4-character code: F91.8 Other conduct disorders
6C91.Z Conduct-dissocial disorder, unspecified
F91.9 Conduct disorder, unspecified
6C9Y Other specified disruptive behaviour or
dissocial disorder
F91.8 Other conduct disorders
801
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6C9Z Disruptive behaviour or dissocial disorder,
unspecified
F91.9 Conduct disorder, unspecified
Personality disorders and related traits
This ICD-11 grouping
first requires the
diagnosis and severity
of a personality disorder
using the following
categories:
• 6D10.0 Mild
personality disorder
• 6D10.1 Moderate
personality disorder
• 6D10.2 Severe
personality disorder
• 6D10.Z Personality
disorder, severity
unspecified.
The 6D10.x category
above can then be
described by indicating
the presence of one or
more of the following
trait domains included
in 6D11 Prominent
personality traits or
patterns:
• 6D11.0 Negative
affectivity in
personality disorder
or personality
difficulty
• 6D11.1 Detachment in
personality disorder
or personality
difficulty
• 6D11.2 Dissociality in
personality disorder
or personality
difficulty
• 6D11.3 Disinhibition in
personality disorder
or personality
difficulty
• 6D11.4 Anankastia in
personality disorder
or personality
difficulty
• 6D11.5 Borderline
pattern.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6D10 Personality disorder
F60 Specific Personality Disorders
4-character code: F60.9 Personality disorder, unspecified
6D10.0 Mild personality disorder
F60.9 Personality disorder, unspecified
Use if categories
from 6D11 Prominent
personality traits
or patterns are not
available.
6D10.1 Moderate personality disorder
F60.9 Personality disorder, unspecified
Use if categories
from 6D11 Prominent
personality traits
or patterns are not
available.
6D10.2 Severe personality disorder
F60.9 Personality disorder, unspecified
Use if categories
from 6D11 Prominent
personality traits
or patterns are not
available.
6D10.Z Personality disorder, severity unspecified
F60.9 Personality disorder, unspecified
Use if categories
from 6D11 Prominent
personality traits
or patterns are not
available.
6D10.x
AND
6D11.0 Negative affectivity
6D11.1 Detachment
6D11.2 Dissociality
(6D10.x/6D11.0/6D11.1/6D11.2)
F60.0 Paranoid personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
6D10.x
AND
6D11.1 Detachment
(6D10.x/6D11.1)
F60.1 Schizoid personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
6D10.x
AND
6D11.2 Dissociality
6D11.3 Disinhibition
(6D10.x/6D11.2/6D11.3)
F60.2 Dissocial personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
803
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6D10.x
AND
6D11.0 Negative affectivity
6D11.3 Disinhibition
(6D10.x/6D11.0/6D11.3)
OR
6D10.x
AND
6D11.5 Borderline pattern, with or without any other
combination of prominent personality traits or patterns
(6D10.x/6D11.5/…)
F60.31 Emotionally unstable personality disorder, borderline
type
4-character code: F60.3 Emotionally unstable personality
disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
6D10.x
AND
6D11.0 Negative affectivity
6D11.2 Dissociality
6D11.3 Disinhibition
((6D10.x/6D11.0/6D11.2/6D11.3)
F60.4 Histrionic personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
6D10.x
AND
6D11.0 Negative affectivity
6D11.4 Anankastia
(6D10.x/6D11.0/6D11.4)
F60.5 Anankastic personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
6D10.x
AND
6D11.0 Negative affectivity
6D11.1 Detachment
(6D10.x/6D11.0/6D11.1)
F60.6 Anxious [avoidant] personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
6D10.x
AND
6D11.0 Negative affectivity
(6D10.x/6D11.0)
F60.7 Dependent personality disorder
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6D10.x
AND
any combination of prominent personality traits or
patterns not listed above
F60.8 Other specific personality disorders
The x in the left column
is a placeholder for
the digit indicating the
severity level of the
personality disorder:
• 0 = Mild
• 1 = Moderate
• 2 = Severe
• Z = Severity
unspecified.
Paraphilic disorders
6D30 Exhibitionistic disorder
F65.2 Exhibitionism
6D31 Voyeuristic disorder
F65.3 Voyeurism
6D32 Paedophilic disorder
F65.4 Paedophilia
6D33 Coercive sexual sadism disorder
F65.8 Other disorders of sexual preference
6D34 Frotteuristic disorder
F65.8 Other disorders of sexual preference
6D35 Other paraphilic disorder involving nonconsenting individuals
F65.8 Other disorders of sexual preference
6D36 Paraphilic disorder involving solitary
behaviour or consenting individuals
F65.8 Other disorders of sexual preference
6D3Z Paraphilic disorder, unspecified
F65.9 Disorder of sexual preference, unspecified
Factitious disorders
6D50 Factitious disorder imposed on self
F68.1 Intentional production or feigning of symptoms or
disabilities, either physical or psychological [factitious
disorder]
6D51 Factitious disorder imposed on another
F68.1 Intentional production or feigning of symptoms or
disabilities, either physical or psychological [factitious
disorder]
6D5Z Factitious disorder, unspecified
F68.1 Intentional production or feigning of symptoms or
disabilities, either physical or psychological [factitious
disorder]
Neurocognitive disorders
6D70 Delirium
Etiology must be specified (see below).
6D70.0 Delirium due to disease classified elsewhere
F05 Delirium, not induced by alcohol and other psychoactive
substances
4-character code: F05.8 Other delirium
805
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6D70.1 Delirium due to psychoactive substances,
including medications
F1x.03 Mental and behavioural disorders due to psychoactive
substance use: acute intoxication with delirium
4-character code: F1x.0 Mental and behavioural disorders
due to psychoactive substance use: acute intoxication
OR
F1x.4 Mental and behavioural disorders due to psychoactive
substance use: withdrawal state with delirium
OR
F1x.8 Mental and behavioural disorders due to psychoactive
substance use: other mental and behavioural disorders
The x in the middle
column is a placeholder
for the digit indicating
the substance class in
ICD-10:
• 0 = alcohol
• 1 = opioids
• 2 = cannabinoids
• 3 = sedatives or
hypnotics
• 4 = cocaine
• 5 = stimulants,
including caffeine
• 6 = hallucinogens
• 7 = tobacco
• 8 = volatile solvents
• 9 = multiple or
other psychoactive
substances.
Use F1x.8 if intoxication/
withdrawal status is
unknown.
6D70.2 Delirium due to multiple etiological factors
F05 Delirium, not induced by alcohol and other psychoactive
substances
4-character code: F05.8 Other delirium
OR
F19.4 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances withdrawal
state with delirium
Use F05 or F05.8 unless
multiple etiological
factors refer entirely to
multiple psychoactive
substances, in which
case F19.4 should be
used.
6D70.Y Delirium, other specified cause
F05.8 Other delirium
6D70.Z Delirium, unknown or unspecified cause
F05.9 Delirium, unspecified
6D71 Mild neurocognitive disorder
F06.7 Mild cognitive disorder
6D72 Amnestic disorder
Etiology must be specified (see below).
6D72.0 Amnestic disorder due to diseases classified
elsewhere
F04 Organic amnesic syndrome, not induced by alcohol and
other psychoactive substances
No 4-character code available
6D72.1 Amnestic disorder due to psychoactive
substances, including medications
Substance must be specified (see below).
6D72.10 Amnestic disorder due to use of alcohol
F10.6 Mental and behavioural disorders due to use of alcohol:
amnesic syndrome
6D72.11 Amnestic disorder due to use of sedatives,
hypnotics or anxiolytics
F13.6 Mental and behavioural disorders due to use of
sedatives or hypnotics: amnesic syndrome
6D72.12 Amnestic disorder due to other specified
psychoactive substance, including medications
F19.6 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: amnesic
syndrome
6D72.13 Amnestic disorder due to use of volatile
inhalants
F18.6 Mental and behavioural disorders due to use of volatile
solvents: amnesic syndrome
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6D72.Y Amnestic disorder, other specified cause
F04 Organic amnesic syndrome, not induced by alcohol and
other psychoactive substances
No 4-character code available
6D72.Z Amnestic disorder, unknown or unspecified
cause
F04 Organic amnesic syndrome, not induced by alcohol and
other psychoactive substances
No 4-character code available
OR
F19.6 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substance uses: amnesic
syndrome
If insufficient
information is
available to make a
general etiological
determination, use F04.
Dementia
Etiology must be specified (see below).
6D80 Dementia due to Alzheimer disease
F00 Dementia in Alzheimer disease
4-character code: F00.9 Dementia in Alzheimer disease,
unspecified
6D80.0 Dementia due to Alzheimer disease with early
onset
F00.0 Dementia in Alzheimer disease with early onset
6D80.1 Dementia due to Alzheimer disease with late
onset
F00.1 Dementia in Alzheimer disease with late onset
6D80.2 Alzheimer disease dementia, mixed type, with
cerebrovascular disease
F00.2 Dementia in Alzheimer disease, atypical or mixed type
6D80.3 Alzheimer disease dementia, mixed type, with
other nonvascular etiologies
F00.2 Dementia in Alzheimer disease, atypical or mixed type
6D80.Z Dementia due to Alzheimer disease, onset
unknown or unspecified
F00.9 Dementia in Alzheimer disease, unspecified
6D81 Dementia due to cerebrovascular disease
F01 Vascular dementia
4-character code: F01.9 Vascular dementia, unspecified
6D82 Dementia due to Lewy body disease
F02.8 Dementia in other diseases classified elsewhere
6D83 Frontotemporal dementia
F02 Dementia in other diseases classified elsewhere
No 4-character code available
OR
F02.0 Dementia in Pick disease
6D84 Dementia due to psychoactive substances,
including medications
Substance must be specified (see below).
807
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6D84.0 Dementia due to use of alcohol
F10.73 Mental and behavioural disorders due to use of
alcohol: residual and late-onset psychotic disorder, dementia
4-character code: F10.7 Mental and behavioural disorders
due to use of alcohol: residual and late-onset psychotic
disorder
6D84.1 Dementia due to use of sedatives, hypnotics or
anxiolytics
F13.73 Mental and behavioural disorders due to use of
sedatives or hypnotics: residual and late-onset psychotic
disorder, dementia
4-character code: F13.7 Mental and behavioural disorders
due to use of sedatives or hypnotics: residual and late-onset
psychotic disorder
6D84.2 Dementia due to use of volatile inhalants
F18.73 Mental and behavioural disorders due to use of volatile
solvents: residual and late-onset psychotic disorder, dementia
4-character code: F18.7 Mental and behavioural disorders
due to use of volatile solvents: residual and late-onset
psychotic disorder
6D84.Y Dementia due to other specified psychoactive
substance
F19.73 Mental and behavioural disorders due to multiple drug
use and use of other psychoactive substances: residual and
late-onset psychotic disorder, dementia
4-character code: F19.7 Mental and behavioural disorders
due to multiple drug use and use of other psychoactive
substances: residual and late-onset psychotic disorder
6D85 Dementia due to diseases classified
elsewhere
F02 Dementia in other diseases classified elsewhere
No 4-character code available
6D85.0 Dementia due to Parkinson disease
F02.3 Dementia in Parkinson disease
6D85.1 Dementia due to Huntington disease
F02.2 Dementia in Huntington disease
6D85.2 Dementia due to exposure to heavy metals and
other toxins
F02.8 Dementia in other diseases classified elsewhere
6D85.3 Dementia due to HIV
F02.4 Dementia in human immunodeficiency virus [HIV]
disease
6D85.4 Dementia due to multiple sclerosis
F02.8 Dementia in other diseases classified elsewhere
6D85.5 Dementia due to prion disease
F02.1 Dementia in Creutzfeldt-Jakob disease
OR
F02.8 Dementia in other specified diseases classified
elsewhere
6D85.6 Dementia due to normal-pressure
hydrocephalus
F02.8 Dementia in other diseases classified elsewhere
6D85.7 Dementia due to injury to the head
F02.8 Dementia in other diseases classified elsewhere
6D85.8 Dementia due to pellagra
F02.8 Dementia in other diseases classified elsewhere
6D85.9 Dementia due to Down syndrome
F02.8 Dementia in other diseases classified elsewhere
6D85.Y Dementia due to other specified disease
classified elsewhere
F02.8 Dementia in other diseases classified elsewhere
6D8Y Dementia, other specified cause
F02.8 Dementia in other specified diseases classified
elsewhere
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders
ICD-11
ICD-10
Notes
6D8Z Dementia, unknown or unspecified cause
F03 Unspecified dementia
No 4-character code available
Mental and behavioural disorders associated with pregnancy, childbirth or the puerperium
6E20 Mental and behavioural disorders associated
with pregnancy, childbirth or the puerperium,
without psychotic symptoms
O99.3 Mental disorders and diseases of the nervous system
complicating pregnancy, childbirth and the puerperium
6E21 Mental and behavioural disorders associated
with pregnancy, childbirth or the puerperium, with
psychotic symptoms
O99.3 Mental disorders and diseases of the nervous system
complicating pregnancy, childbirth and the puerperium
6E2Z Mental and behavioural disorders associated
with pregnancy, childbirth or the puerperium,
unspecified
O99.3 Mental disorders and diseases of the nervous system
complicating pregnancy, childbirth and the puerperium
Psychological or behavioural factors affecting disorders or diseases classified elsewhere
6E40 Psychological or behavioural factors affecting
disorders and diseases classified elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
6E40.0 Mental disorder affecting disorders and
diseases classified elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
6E40.1 Psychological symptoms affecting disorders
and diseases classified elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
6E40.2 Personality traits or coping style affecting
disorders and diseases classified elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
6E40.3 Maladaptive health behaviours affecting
disorders and diseases classified elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
6E40.4 Stress-related physiological response affecting
disorders and diseases classified elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
6E40.Y Other specified psychological or behavioural
factor affecting disorders and diseases classified
elsewhere
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
809
Crosswalk from ICD-11 mental, behavioural and neurodevelopmental disorders to ICD-10 for clinician use
ICD-11
ICD-10
Notes
6E40.Z Psychological or behavioural factor affecting
disorders and diseases classified elsewhere,
unspecified
F54 Psychological and behavioural factors associated with
disorders or diseases classified elsewhere
No 4-character code available
Secondary mental or behavioural syndromes associated with disorders and diseases classified elsewhere
6E60 Secondary neurodevelopmental syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E60.0 Secondary speech or language syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E60.Y Other specified secondary neurodevelopmental
syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E60.Z Secondary neurodevelopmental syndrome,
unspecified
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E61 Secondary psychotic syndrome
F06.0 Organic hallucinosis
OR
F06.2 Organic delusional [schizophrenia-like] disorder
Select F06.0 or F06.2
based on whether
hallucinations or
delusions predominate,
although both may
occur in either category.
6E61.0 Secondary psychotic syndrome with
hallucinations
F06.0 Organic hallucinosis
6E61.1 Secondary psychotic syndrome with delusions
F06.2 Organic delusional [schizophrenia-like] disorder
6E61.2 Secondary psychotic syndrome with
hallucinations and delusions
F06.2 Organic delusional [schizophrenia-like] disorder
6E61.3 Secondary psychotic syndrome with
unspecified symptoms
F09 Unspecified organic or symptomatic mental disorder
6E62 Secondary mood syndrome
F06.3 Organic mood [affective] disorders
6E62.0 Secondary mood syndrome with depressive
symptoms
F06.32 Organic depressive disorder
4-character code: F06.3 Organic mood [affective] disorders
6E62.1 Secondary mood syndrome with manic
symptoms
F06.30 Organic manic disorder
4-character code: F06.3 Organic mood [affective] disorders
6E62.2 Secondary mood syndrome with mixed
symptoms
F06.33 Organic mixed affective disorder
4-character code: F06.3 Organic mood [affective] disorders
6E62.3 Secondary mood syndrome with unspecified
symptoms
F06.3 Organic mood [affective] disorders
6E63 Secondary anxiety syndrome
F06.4 Organic anxiety disorder
6E64 Secondary obsessive-compulsive or related
syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E65 Secondary dissociative syndrome
F06.5 Organic dissociative disorder
6E66 Secondary impulse control syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E67 Secondary neurocognitive syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E68 Secondary personality change
F07.0 Organic personality disorder
6E69 Secondary catatonia syndrome
F06.1 Organic catatonic disorder
6E6Y Other specified secondary mental or
behavioural syndrome
F06.8 Other specified mental disorders due to brain damage
and dysfunction and to physical disease
6E6Z Secondary mental or behavioural syndrome,
unspecified
F06.9 Unspecified mental disorder due to brain damage and
dysfunction and to physical disease
Clinical Descriptions and Diagnostic Requirements for ICD-11 Mental, Behavioural or Neurodevelopmental Disorders