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Treatment – first steps Schizophrenia and related psychoses CHAPTER 1 Treatment of tardive dyskinesia Tardive dyskinesia is a somewhat less commonly encountered problem now than in previous decades,1,2 probably because of the more widespread use of SGAs,3–6 wh...

Treatment – additional agents

Treatment – other possible options 136 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Treatment – other possible options The large number of proposed treatments for TD undoubtedly reflects the somewhat limited effectiveness of standard remedies, ...

High-dose antipsychotic medication: prescribing and monitoring

References Schizophrenia and related psychoses CHAPTER 1 Table 1.30  Other options for the treatment of tardive dyskinesia (in alphabetical order). Drug Comments Amino acids85 Use is supported by a small randomised, placebo-­controlled trial. Low risk of toxic...

Antipsychotic-induced weight gain Schizophrenia and related psychoses CHAPTER 1 Antipsychotic-­induced weight gain Weight gain is a common adverse effect of antipsychotic medication.1 This may reflect interference with the homeostatic control of appetite and m...

Time course

Dose–response 142 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Time course Antipsychotic-­induced weight gain occurs primarily in the first few months of treatment but continues for many months or even years afterwards. In a 10-­year study of p...

References Schizophrenia and related psychoses CHAPTER 1 References Barton BB, et al. Update on weight-­gain caused by antipsychotics: a systematic review and meta-­analysis. Expert Opin Drug Saf 2020; 19:295–314. Correll CU, et al. Antipsychotic drugs and ob...

Treatment of antipsychotic-induced weight gain

Monitoring

Treatment and prevention 144 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Treatment of antipsychotic-­induced weight gain Weight gain is an important adverse effect of nearly all antipsychotic medications.1,2 Women may be at greater risk than m...

References Schizophrenia and related psychoses CHAPTER 1 References Pillinger T, et al. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology:...

Neuroleptic malignant syndrome 150 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Neuroleptic malignant syndrome NMS occurs as a rare but potentially serious or even fatal adverse effect of antipsychotics and other dopamine antagonists (Table 1.3...

Efficacy Schizophrenia and related psychoses CHAPTER 1 High-­dose antipsychotic medication: prescribing and monitoring ‘High-­dose’ antipsychotic medication can result from the prescription of either a single antipsychotic medication at a dose above the recomm...

References Schizophrenia and related psychoses CHAPTER 1 Risk factors for developing NMS include being male, dehydration, exhaustion and confusion/agitation.4,37 Although NMS has commonly been reported to occur at standard doses of antipsychotics, there is som...

Catatonia 154 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Catatonia Catatonia is a neuropsychiatric disorder that presents with a wide range of signs and symptoms, covering focal and generalised motor activity, speech, affect, complex behaviou...

References 158 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 References Rogers JP, et al. Evidence-­based consensus guidelines for the management of catatonia: recommendations from the British Association for Psychopharmacology. J Psychopharmac...