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153 - ECG changes QT prolongation
ECG changes – QT prolongation
154 - Introduction
Introduction
155 - QT prolongation
QT prolongation Schizophrenia and related psychoses CHAPTER 1 ECG changes – QT prolongation Introduction Many psychotropic drugs are associated with ECG changes and some are causally linked to serious ventricular arrhythmia and sudden cardiac death. Specifical...
156 - Other ECG changes
Other ECG changes
157 - Quantifying risk
Quantifying risk 162 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 ■ ■There is some controversy over the exact association between QTc and risk of arrhythmia. Very limited evidence suggests that risk is exponentially related to the extent of pro...
158 - Other risk factors
Other risk factors 164 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Aripiprazole remains in the low-effect group having previously been firmly placed in ‘no effect’. Data are rather contradictory, with most studies showing a decrease in QTc ass...
159 - ECG monitoring
ECG monitoring
16 - Adverse effects
Adverse effects 18 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 A small number of RCTs have examined the efficacy of high versus standard dosage in patients with treatment-resistant schizophrenia (TRS).1 Some have demonstrated benefit23 but th...
160 - Metabolic inhibition
Metabolic inhibition Schizophrenia and related psychoses CHAPTER 1 Table 1.37 Non-psychotropics associated with QT prolongation (see Crediblemeds.org for latest information; this is not a complete list). Antibiotics Erythromycin Clarithromycin Ampicillin Co-...
161 - Other cardiovascular risk factors
Other cardiovascular risk factors
162 - Summary
Summary
163 - References
References 166 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Other cardiovascular risk factors The risk of drug-induced arrhythmia and sudden cardiac death with psychotropics is an important consideration. With respect to cardiovascular disease...
164 - Effects of antipsychotic medications on plasm
Effects of antipsychotic medications on plasma lipids
165 - Effect of antipsychotic medications on lipids
Effect of antipsychotic medications on lipids
166 - Olanzapine
Olanzapine Schizophrenia and related psychoses CHAPTER 1 Effects of antipsychotic medications on plasma lipids Morbidity and mortality from cardiovascular disease are higher in people with schizophrenia than in the general population.1–3 Dyslipidaemia is an es...
167 - Clozapine
Clozapine
168 - Screening and monitoring
Screening and monitoring
169 - Clinical management of dyslipidaemia
Clinical management of dyslipidaemia 170 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 treated with olanzapine or risperidone gained a similar amount of weight, but with olanzapine, serum triglyceride levels increased by four times as much (105m...