Search Results

Adverse effects

Recommended additional monitoring

Switching from other antipsychotics Schizophrenia and related psychoses CHAPTER 1 Adverse effects Sedation, hypersalivation and hypotension are common at the start of treatment. These effects can usually be managed (see section on clozapine: common adverse eff...

Serious cardiac adverse effects

References 240 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Serious cardiac adverse effects See section on clozapine: serious cardiovascular adverse effects in this chapter. Patients should be closely observed for signs or symptoms of myocardit...

The use of combined antipsychotic medications in clinical practice

CLOZAPINE ADVERSE EFFECTS

Clozapine: common adverse effects Schizophrenia and related psychoses CHAPTER 1 CLOZAPINE ADVERSE EFFECTS Clozapine: common adverse effects This section provides a summary of management of the common adverse effects of clozapine. Adverse effect Time course Act...

References Schizophrenia and related psychoses CHAPTER 1 References Palmer SE, et  al. Life-­threatening clozapine-­induced gastrointestinal hypomotility: an analysis of 102 cases. J Clin Psychiatry 2008; 69:759–768. Taylor D, et al. The Maudsley Practice Gui...

Clozapine: uncommon or unusual adverse effects Schizophrenia and related psychoses CHAPTER 1 Clozapine: uncommon or unusual adverse effects Adverse effect Time course Comment Agranulocytosis (delayed)1–4 Usually first 3 months but may occur at any time Occasio...

References Schizophrenia and related psychoses CHAPTER 1 References Thompson A, et al. Late onset neutropenia with clozapine. Can J Psychiatry 2004; 49:647–648. Bhanji NH, et al. Late-­onset agranulocytosis in a patient with schizophrenia after 17 months of c...

Clozapine: serious haematological adverse effects

Agranulocytosis

Summary Schizophrenia and related psychoses CHAPTER 1 Clozapine: serious haematological adverse effects Agranulocytosis Clozapine is a somewhat toxic drug. Despite this, clozapine reduces overall mortality in schizophrenia,1 in part owing to a reduction in the...

References 252 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 References Vermeulen JM, et al. Clozapine and long-­term mortality risk in patients with schizophrenia: a systematic review and meta-­analysis of studies lasting 1.1–12.5 years. Schiz...

Clozapine: serious cardiovascular adverse effects

Conclusion

Thromboembolism