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Nomenclature

Role of older antipsychotics Schizophrenia and related psychoses CHAPTER 1 First-­generation antipsychotics – place in therapy Nomenclature First-­generation (‘typical’) and second-­generation (‘atypical’) antipsychotic medications are not categorically differ...

References 50 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 alternative to SGAs where SGAs are poorly tolerated (usually because of metabolic changes) or where FGAs are preferred by patients themselves. Some FGAs may be less effective than some ...

NICE guidelines for the treatment of schizophrenia1

NICE guidelines – a summary 52 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 NICE guidelines for the treatment of schizophrenia1 The UK NICE guidelines1 were published in February 2014 and last reviewed in September 2024 but have remained largel...

References 54 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 allow the use of long-­acting agents, as do the BAP guidelines.3 The duration of antipsychotic treatment in first episode is not clearly defined in the NICE guidelines. The Canadian Psy...

Antipsychotic response – to increase the dose, to switch, to add or just wait – what is the right move?

Optimal dosage

High dosage Schizophrenia and related psychoses CHAPTER 1 Antipsychotic response – to increase the dose, to switch, to add or just wait – what is the right move? For any clinician actively involved in the care of people with schizophrenia, perhaps the single m...

Plasma level variations 56 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 ­network meta-­analysis of the dose–response effects of lurasidone in acute schizophrenia suggested that 160mg/day might be the most effective and acceptable dose.9 Several...

Treatment options for schizophrenia that is poorly responsive to standard antipsychotic treatment Schizophrenia and related psychoses CHAPTER 1 have plasma drug levels that are well below the range expected for 2mg risperidone or 10mg olanzapine, and these lev...

Summary Schizophrenia and related psychoses CHAPTER 1 When treatment fails ■ ■If the dose of antipsychotic medication has been optimised, consider watchful waiting. ■ ■Consider increasing the antipsychotic dose according to tolerability and plasma levels (litt...

References 60 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 References Samara MT, et al. Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia. Cochrane Database Syst Rev 2018; (5):CD011884. Barnes T, et...

Acutely disturbed or violent behaviour

Oral/inhaled treatment

Parenteral treatment 62 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Acutely disturbed or violent behaviour Acute behavioural disturbance can occur in the context of psychiatric illness, physical illness, substance abuse or personality disorder...

Practical measures Schizophrenia and related psychoses CHAPTER 1 positive or negative effects and while adding a benzodiazepine to another drug may not be clearly advantageous it may lead to unnecessary adverse effects.49 With respect to those who are behaviou...

Zuclopenthixol acetate 66 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Zuclopenthixol acetate Zuclopenthixol acetate (ZA) is widely used in the UK and elsewhere in Europe, and is best known by its trade name Acuphase®. Zuclopenthixol itself is ...