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Stopping 90 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Olanzapine long-­acting injection Olanzapine pamoate (embonate, in some countries) is a very poorly water-­soluble salt ester of olanzapine. An aqueous suspension of olanzapine pamoate, w...

Post-injection delirium sedation syndrome Schizophrenia and related psychoses CHAPTER 1 Post-­injection delirium sedation syndrome Although the precise mechanism of post-­injection delirium sedation syndrome (PDSS) remains unclear, it is thought to occur when ...

References 92 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 References Heres S, et al. Pharmacokinetics of olanzapine long-­acting injection: the clinical perspective. Int Clin Psychopharmacol 2014; 29:299–312. Mitchell M, et al. Single-­ and m...

Paliperidone palmitate long-acting injection

Paliperidone long-acting injection 1-monthly Schizophrenia and related psychoses CHAPTER 1 Paliperidone palmitate long-­acting injection Paliperidone (9-­hydroxyrisperidone) is the major active metabolite of risperidone. Paliperidone palmitate is the ester pro...

Paliperidone long-acting injection 3-monthly Schizophrenia and related psychoses CHAPTER 1 Paliperidone long-­acting injection 3-­monthly Paliperidone LAI 3-­monthly (PP3M) is indicated for patients who are clinically stable on PP1M and do not require dose adj...

Paliperidone LAI 6-monthly (PP6M) 96 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 (Table 1.20). Dose adjustments should not be necessary but may be made at 3-­monthly intervals thereafter; however, the full response to the new dose may not be a...

References Schizophrenia and related psychoses CHAPTER 1 Dose adjustments should not be needed but can be made every 6 months based on patient response and tolerability. Any dose change may not be apparent in respect to clinical effects for several months owin...

Risperidone long-acting injection

Risperidone intramuscular long-acting injections Schizophrenia and related psychoses CHAPTER 1 Risperidone long-­acting injection In this section we give brief details on the range of risperidone LAIs (RLAIs) available around the world in 2024. We have done ou...

Risperidone subcutaneous long-acting injections Schizophrenia and related psychoses CHAPTER 1 Risperidone ISM® (Risvan, Okedi) Risperidone ISM is an injectable suspension of risperidone suitable for stable patients who have previously responded and tolerated r...

References 104 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 References Knox ED, et al. Clinical review of a long-­acting, injectable formulation of risperidone. Clin Ther 2004; 26:1994–2002. Wilson WH. A visual guide to expected blood levels o...

Penfluridol weekly

Background

Lithium

Mechanism of action

Clinical indications The Maudsley® Prescribing Guidelines in Psychiatry, Fifteenth Edition. David M. Taylor, Thomas R. E. Barnes and Allan H. Young. © 2025 David M. Taylor. Published 2025 by John Wiley & Sons Ltd. Chapter 2 Lithium Mechanism of action Lithium ...

Lithium and suicide