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23 - Use in women of child bearing age
Use in women of child-bearing age
24 - Interactions with other drugs
Interactions with other drugs 292 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 2 Use in women of child-bearing age Valproate is an established human teratogen. NICE recommends that alternative antiseizure medications are preferred in women with ...
25 - References
References Bipolar disorder CHAPTER 2 References Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci 2007; 64:2090–2103. Natale G, et al. Valproate and lithium: old drugs fo...
26 - Carbamazepine
Carbamazepine
27 - Mechanism of action1
Mechanism of action1
28 - Formulations
Formulations
29 - Indications
Indications Bipolar disorder CHAPTER 2 Carbamazepine Mechanism of action1 Carbamazepine blocks voltage-dependent sodium channels, thus inhibiting repetitive neuronal firing. It reduces glutamate release and decreases the turnover of dopamine and noradrenaline...
30 - Plasma levels
Plasma levels
31 - Adverse effects1
Adverse effects1 296 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 2 considered to be superior to carbamazepine in reducing suicidal behaviour,15 although data are not consistent16 and carbamazepine may have anti-suicidal properties.17 In the UK,...
32 - Pre treatment tests
Pre-treatment tests
33 - On treatment monitoring
On-treatment monitoring
34 - Discontinuation
Discontinuation
35 - Use in women of child bearing age
Use in women of child-bearing age
36 - Interactions with other drugs4144
Interactions with other drugs41–44 Bipolar disorder CHAPTER 2 and a specificity approaching 100% in certain populations.32 Genetic testing in people from South-East Asia is recommended before carbamazepine is prescribed. Carbamazepine is a known human teratog...
37 - References
References 298 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 2 resulting in treatment failure. Patients requiring contraception should either receive a preparation containing not less than 50mcg oestrogen or use a non-hormonal method. Drugs that ...
38 - Antipsychotic drugs in bipolar disorder
Antipsychotic drugs in bipolar disorder
39 - First generation antipsychotics
First-generation antipsychotics
40 - Second generation antipsychotics
Second-generation antipsychotics 300 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 2 Antipsychotic drugs in bipolar disorder Antipsychotic drugs not only have activity that reduces psychotic symptoms,1 individual antipsychotics variously possess ...