Search Results

Use in psychosis 462 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Epidemiological research has linked benzodiazepine prescribing to serious medical conditions including dementia, infections and cancer.38–41 However, a causal relationship has no...

Adverse effects

Drug interactions Depression and anxiety disorders CHAPTER 3 15. Roehrs T, et al. Drug-­related sleep stage changes: functional significance and clinical relevance. Sleep Med Clin 2010; 5:559–570. 16. Yue JL, et al. Efficacy and tolerability of pharmacological...

References 464 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Benzodiazepines, z-­drugs and gabapentinoids: dependence, withdrawal effects and discontinuation In most developed countries, the use of benzodiazepines or z-­drugs is restricted to a ...

Benzodiazepines, z-drugs and gabapentinoids: dependence, withdrawal effects and discontinuation 466 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Stopping benzodiazepines If the patient is in agreement, benzodiazepines should be withdrawn. Taper...

Withdrawal symptoms Depression and anxiety disorders CHAPTER 3 patients with hepatic dysfunction, as diazepam and other longer-­acting drugs may accumulate to toxic levels. Pattern of tapering The relationship between dose of benzodiazepines and their effect o...

Stopping benzodiazepines

Dosage reduction (tapering)

Recognised minimum effective doses of antidepressants 342 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Recognised minimum effective doses of antidepressants The recommended minimum effective doses of antidepressants are summarised in Table 3.2....

Direct taper or switching to diazepam?

Pattern of tapering 468 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Practical application of these principles Before tapering ■ ■All patients should be informed of the risk of withdrawal symptoms on stopping any benzodiazepine, z-­drug or gaba...

Practical application of these principles Depression and anxiety disorders CHAPTER 3 with smaller reductions than they have been undertaking (some need to taper at less than 5% of the most recent dose per month). ■ ■At very small doses, liquid formulations or ...

Troubleshooting

Reduction schedules 470 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 11. Horowitz M, et al. The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-­drugs. Oxford: Wiley-­ Blackwell; 2024. 12. Horowitz MA, ...

Tapering other drug classes

References Depression and anxiety disorders CHAPTER 3 Benzodiazepines and disinhibition Unexpected increases in aggressive or impulsive behaviour secondary to drug treatment are usually called disinhibitory or paradoxical reactions. These reactions may include...

Benzodiazepines and disinhibition

How common are disinhibitory reactions with benzodiazepines? 472 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 short-­acting drugs given intravenously are extremely likely to cause disinhibition in personality disorder. What is the mechanism? Va...