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References Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 A 2023 systematic review concluded that dolutegravir-­based regimens led to higher discontinuation rates due to neuropsychiatric adverse effects compared with those...

Epilepsy

Psychiatric comorbidities in epilepsy Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Epilepsy Psychiatric comorbidities in epilepsy People with epilepsy (PWE) have an elevated prevalence of several psychiatric disorders in...

Psychiatric side effects of antiseizure medications 812 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Psychiatric side effects of antiseizure medications Virtually all antiseizure medications are known to have psychotropic effects. These effect...

Interactions of antiseizure medications22 Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Interactions of antiseizure medications22 Pharmacokinetic interactions Important pharmacokinetic interactions occur in both direction...

Psychotropics and the risk of seizures in people with epilepsy 814 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Pharmacodynamic interactions14 Adverse effects with antiseizure medications that may overlap with psychotropic adverse effects incl...

Epilepsy and driving

References Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Epilepsy and driving In the UK, people with epilepsy may not drive a car if they have had a seizure while awake in the previous year. However, they may be eligible ...

22q11.2 deletion syndrome

Clinical features 820 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 22q11.2 deletion syndrome Clinical features 22q11.2 deletion syndrome (22q11.2DS), the most common microdeletion syndrome in humans, is a multisystem disorder with a heterogeno...

Psychiatric disorders in people with 22q11.2DS Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Psychiatric disorders in people with 22q11.2DS Around 60% of people with 22q11.2DS meet diagnostic criteria for some type of ­ps...

References 822 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 References Boot E, et al. Updated clinical practice recommendations for managing adults with 22q11.2 deletion syndrome. Genet Med 2023; 25:100344. McDonald-­McGinn DM, et al. 22q11.2...

Learning disabilities

General considerations1

Key practice areas 824 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Learning disabilities General considerations1 Prescribing psychotropic medications for people with learning disabilities (LD) is a ­challenging and controversial area of psych...

References Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 References Deb S. The use of medications for the management of problem (challenging) behaviours in adults who have intellectual disabilities. University of Hertfor...

Huntington’s disease

Motor symptoms 830 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Huntington’s disease Huntington’s disease (HD) is a genetic neurodegenerative disease with an estimated prevalence of 4.88 individuals per 100,000 worldwide, and a higher incidenc...