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Mental and behavioural symptoms Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Mental and behavioural symptoms A wide variety of mental and behavioural symptoms occur in HD, including anxiety, depression, suicidality, pres...

Cognitive symptoms

References 834 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Cognitive symptoms Cognitive disturbances may emerge many years before motor disturbances.7 The progression of cognitive decline is gradual25 and dementia is inevitable in late stages...

Multiple sclerosis

Depression Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Multiple sclerosis Individuals with multiple sclerosis (MS) experience a variety of psychiatric and neurological disorders. These include depression, anxiety, patho...

Anxiety

Pseudobulbar affect

Bipolar disorder

Psychosis 836 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Anxiety Anxiety affects many people with MS, with a point prevalence of up to 50%36 and lifetime incidence of 35–37%.37 Elevated rates in comparison with the general ­population are se...

Cognitive impairment

Fatigue Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 ­published trials, but risperidone or clozapine has been recommended because of the low risk of extrapyramidal symptoms.55 On this basis, olanzapine, aripiprazole and ...

References 838 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 References Marrie RA, et  al. The incidence and prevalence of psychiatric disorders in multiple sclerosis: a systematic review. Mult Scler 2015; 21:305–317. Gottberg K, et al. A popu...

Parkinson’s disease

Depression 840 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Parkinson’s disease Psychiatric comorbidity is common in Parkinson’s disease (PD). Approximately 25% of PD patients will suffer from major depression, a further 25% from milder forms ...

Psychosis Drug treatment of psychiatric symptoms in the context of other conditions CHAPTER 10 Psychosis Psychosis in PD is often characterised by visual hallucinations.28 Auditory hallucinations and delusions occur far less frequently,29 and usually in younge...

Pimavanserin

Cholinesterase inhibitors

Other treatments 842 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 10 Pimavanserin Pimavanserin is a 5-­HT2A receptor inverse agonist available in the USA and some other countries. It is effective in PD psychosis but has no dopamine receptor activ...