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110 Chronic Myeloid Leukemia alone frequently died from DIC induced by the release of gran­ ule components by the chemotherapy-treated leukemia cells. The prognosis of APL patients changed dramatically first with the introduction of tretinoin (all-trans-retino...

111 Acute Lymphoid Leukemia Dieter Hoelzer Acute Lymphoid Leukemia In acute lymphoblastic leukemia (ALL), the malignant clone arises from hematopoietic progenitors in the bone marrow or lymphatic system resulting in an increase of immature nonfunctioning leuke...

112 Chronic Lymphocytic Leukemia least eight or more cycles. This leads to a significant increase in MRD negativity and improved survival. Anti-CD22  Monoclonal antibodies directed against CD22 are linked to cytotoxic agents, such as calicheamicin (inotuzumab ...

113 Non-Hodgkin’s Lymphoma Caron A. Jacobson, Dan L. Longo Non-Hodgkin’s Lymphoma Non-Hodgkin’s lymphomas (NHLs) are cancers of mature B, T, and natural killer (NK) cells. They were distinguished from Hodgkin’s lym­ phoma (HL) upon recognition of the Reed-Ster...

114 Hodgkin’s Lymphoma FIGURE 113-7  Adult T-cell leukemia/lymphoma. Peripheral blood smear showing leukemia cells with typical “flower-shaped” nucleus. EBV infection in nearly all cases and more common in Asia and native populations in Peru. It usually presen...

115 Less Common Lymphoid and Myeloid Malignancies SURVIVORSHIP Because of the very high cure rate in patients with HL, long-term complications have become a major focus for clinical research. In fact, in some series of patients with early-stage disease, more p...

116 Plasma Cell Disorders Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson Plasma Cell Disorders The plasma cell disorders are monoclonal neoplasms related to each other by virtue of their development from common progenitors in the late B-lymphocyte lineage...

117 Amyloidosis the assembly of light and heavy chains because they appear to contain both in their cytoplasm. Such patients are not treated differently from other patients with CLL (Chap. 107). ■ ■FURTHER READING Corre J et al: Risk factors in multiple myelom...

118 Transfusion Therapy and Biology Pierre Tiberghien, Olivier Garraud, Jacques Chiaroni Transfusion Therapy and Biology Transfusion encompasses the use of blood components (BCs) to pre­ vent or treat anemia, hemorrhage, and bleeding disorders. Occasion­ ally,...

119 Hematopoietic Cell Transplantation Frederick R. Appelbaum Hematopoietic Cell Transplantation Bone marrow transplantation was the original term used to describe the collection and transplantation of hematopoietic stem cells, but with the demonstration that ...

SECTION 3 Disorders of Hemostasis Section 3 Disorders of Hemostasis Barbara A. Konkle Disorders of Platelets and Vessel Wall Hemostasis is a dynamic process in which the platelet and the blood vessel wall play key roles. Platelets are activated upon adhesion ...

120 Disorders of Platelets and Vessel Wall Section 3 Disorders of Hemostasis Barbara A. Konkle Disorders of Platelets and Vessel Wall Hemostasis is a dynamic process in which the platelet and the blood vessel wall play key roles. Platelets are activated upon ...

121 Coagulation Disorders Gomez K: Advances in the diagnosis of heritable platelet disorders. Blood Rev 56:100972, 2022. James PD et al: ASH ISTH NHF WFH 2021 guidelines on the diagno­ sis of von Willebrand disease. Blood Adv 5:280, 2021. Jiang D et al: Changi...

122 Arterial and Venous Thrombosis Jane E. Freedman, Joseph Loscalzo Arterial and Venous Thrombosis OVERVIEW OF THROMBOSIS ■ ■GENERAL OVERVIEW Thrombosis is hemostasis “at the wrong place and at the wrong time” (MacFarlane). The obstruction of blood flow due t...

123 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs risk remains low (1 in 6000). The relative risk of VTE among pregnant or postpartum women is 4.3, and the overall incidence (absolute risk) is 199.7 per 100,000 woman-years. ■ ■GENETICS OF VENOUS THROMBOS...

SECTION 1 Basic Considerations in Infectious Diseases Section 1 Basic Considerations in Infectious Diseases Neeraj K. Surana, Dennis L. Kasper Approach to the Patient with an Infectious Disease ■ ■HISTORIC PERSPECTIVE The origins of the field of infectious di...

124 Approach to the Patient with an Infectious Disease Section 1 Basic Considerations in Infectious Diseases Neeraj K. Surana, Dennis L. Kasper Approach to the Patient with an Infectious Disease ■ ■HISTORIC PERSPECTIVE The origins of the field of infectious d...

125 Molecular Mechanisms of Microbial Pathogenesis TABLE 124-5  Initial Empirical Antibiotic Therapy for Common Infectious Disease Presentationsa CLINICAL SYNDROME COMMON ETIOLOGIES ANTIBIOTIC(S) COMMENTS SEE CHAPTER(S) Skin and soft tissue infection S. aureus...