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Optimising lithium treatment45

Combination treatment Bipolar disorder CHAPTER 2 risperidone LAI is well supported by RCTs39 and naturalistic studies.40 The prescribing of LAI SGAs is generally encouraged despite some labelling restrictions41–­44 (see ‘Antipsychotic long-acting injections in...

References Bipolar disorder CHAPTER 2 References Malhi GS, et al. The 2020 Royal Australian and New Zealand College of Psychiatrists Clinical Practice Guidelines for Mood Disorders: bipolar disorder summary. Bipolar Disord 2020; 22:805–­821. Yatham LN, et al....

Stopping lithium and mood stabilisers

Rationale for stopping

Withdrawal effects from lithium and other mood stabilisers Bipolar disorder CHAPTER 2 Stopping lithium and mood stabilisers Rationale for stopping Patients may ask to stop lithium and other mood stabilisers because of the range of adverse effects experienced. ...

Evidence for long-term treatment

Duration of tapering

Pattern of tapering 332 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 2 Evidence for long-­term treatment Although lithium is accepted as the first-­line choice for prophylaxis in bipolar disorder,9 evidence for long-­term treatment with lithium a...

Practice guide to tapering

References Bipolar disorder CHAPTER 2 Practice guide to tapering ■ ■Patients should be told that there is the possibility of withdrawal effects, and that there may be an increased risk of affective relapse from stopping lithium or mood stabilisers more quickly...

Introduction to depression The Maudsley® Prescribing Guidelines in Psychiatry, Fifteenth Edition. David M. Taylor, Thomas R. E. Barnes and Allan H. Young. © 2025 David M. Taylor. Published 2025 by John Wiley & Sons Ltd. Chapter 3 Introduction to depression Dep...

Official guidance on the treatment of depression: a summary of the NICE guidelines1

References 336 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Official guidance on the treatment of depression: a summary of the NICE guidelines1 ■ ■Depression severity is categorised as less severe (includes subthreshold and mild depression) and...

Antidepressants – general overview

Effectiveness Depression and anxiety disorders CHAPTER 3 Antidepressants – general overview Effectiveness All antidepressants are more efficacious than placebo in adults with MDD1 and there is broadly equal benefit from antidepressant treatments for mild, mode...

Onset of action

Choice of antidepressant and relative adverse effects 338 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 3 Onset of action It is widely believed that antidepressants do not exert their effects for 2–4 weeks, or even longer. This is a myth. All anti...