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22.3.4 Chronic myeloid leukaemia 5213 Mhairi Copla
22.3.4 Chronic myeloid leukaemia 5213 Mhairi Copland and Tessa L. Holyoake† 22.3.4 Chronic myeloid leukaemia 5213 22.3.4 Chronic myeloid leukaemia Mhairi Copland and Tessa L. Holyoake† ESSENTIALS Chronic myeloid leukaemia (CML) has a worldwide incidence of 1...
22.3.5 The polycythaemias 5227 Daniel Aruch and Ro
22.3.5 The polycythaemias 5227 Daniel Aruch and Ronald Hoffman 22.3.5 The polycythaemias 5227 Latif A-L, et al. (2013). Allogeneic stem cell transplantation for Chronic Myeloid Leukemia is safe and effective in high risk patients fol- lowing second generatio...
22.3.6 Thrombocytosis and essential thrombocythaem
22.3.6 Thrombocytosis and essential thrombocythaemia 5239 Daniel Aruch and Ronald Hoffman 22.3.6 Thrombocytosis and essential thrombocythaemia 5239 FURTHER READING Arber DA, et al. (2016). The 2016 revision to the World Health Organization (WHO) classificati...
22.3.7 Primary myelofibrosis 5247 Evan M. Braunste
22.3.7 Primary myelofibrosis 5247 Evan M. Braunstein and Jerry L. Spivak 22.3.7 Primary myelofibrosis 5247 Karow A, et al. (2015). Mutational profile of childhood myeloproliferative neoplasms. Leukemia, 29, 2407–9. Kaushansky K (2005). The molecular mechani...
22.3.8 Eosinophilia 5254 Peter F. Weller
22.3.8 Eosinophilia 5254 Peter F. Weller SECTION 22 Haematological disorders 5254 22.3.8 Eosinophilia Peter F. Weller ESSENTIALS Eosinophilia (eosinophil count >0.45 × 109/litre) is associated with some infections, some allergic diseases, and a variety of o...
22.3.9 Histiocytosis 5259 Chris Hatton
22.3.9 Histiocytosis 5259 Chris Hatton 22.3.9 Histiocytosis 5259 22.3.9 Histiocytosis Chris Hatton ESSENTIALS The histiocytoses are disorders derived from the dendritic cell and monocyte/macrophage lineages, with the classification of this group of disorder...
22.4 Lymphoid disease 5263 22.4.1 Introduction to
22.4 Lymphoid disease 5263 22.4.1 Introduction to lymphopoiesis 5263 Caron A. Jacobson and Nancy Berliner 22.4 Lymphoid disease CONTENTS 22.4.1 Introduction to lymphopoiesis 5263 Caron A. Jacobson and Nancy Berliner 22.4.2 Acute lymphoblastic leukaemia 526...
22.4.2 Acute lymphoblastic leukaemia 5269 H. Josef
22.4.2 Acute lymphoblastic leukaemia 5269 H. Josef Vormoor, Tobias F. Menne, and Anthony V. Moorman 22.4.2 Acute lymphoblastic leukaemia 5269 single cell with a rearranged antigen receptor locus. The pattern of gene rearrangement helps to characterize the lin...
22.4.3 Hodgkin lymphoma 5280 Vijaya Raj Bhatt and
22.4.3 Hodgkin lymphoma 5280 Vijaya Raj Bhatt and James O. Armitage section 22 Haematological disorders 5280 Moorman AV (2012). The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leu- kaemia. Blood Rev, 26...
22.4.4 Non- Hodgkin lymphoma 5288 Vijaya Raj Bhatt
22.4.4 Non- Hodgkin lymphoma 5288 Vijaya Raj Bhatt and James O. Armitage section 22 Haematological disorders 5288 22.4.4 Non-Hodgkin lymphoma Vijaya Raj Bhatt and James O. Armitage ESSENTIALS Non-Hodgkin lymphomas comprise precursor lymphoid neo- plasms, m...
22.4.5 Chronic lymphocytic leukaemia 5302 Clive S.
22.4.5 Chronic lymphocytic leukaemia 5302 Clive S. Zent and Aaron Polliack section 22 Haematological disorders 5302 The Non-Hodgkin’s Lymphoma Classification Project (1997). A clinical evaluation of the International Lymphoma Study Group Classification of No...
22.4.6 Plasma cell myeloma and related monoclonal
22.4.6 Plasma cell myeloma and related monoclonal gammopathies 5310 S. Vincent Rajkumar and Robert A. Kyle section 22 Haematological disorders 5310 Royle JA, et al. (2011). Second cancer incidence and cancer mortality among chronic lymphocytic leukaemia patie...
22.5 Bone marrow failure 5325 22.5.1 Inherited bon
22.5 Bone marrow failure 5325 22.5.1 Inherited bone marrow failure syndromes 5325 Irene Roberts and Inderjeet S. Dokal CONTENTS 22.5.1 Inherited bone marrow failure syndromes 5325 Irene Roberts and Inderjeet S. Dokal 22.5.2 Acquired aplastic anaemia and pur...
22.5.2 Acquired aplastic anaemia and pure red cell
22.5.2 Acquired aplastic anaemia and pure red cell aplasia 5336 Judith C.W. Marsh, Shreyans Gandhi, and Ghulam J. Mufti section 22 Haematological disorders 5336 Iolascon A, et al. (2013). Congenital dyserythropoietic anemias: mo- lecular insights and diagnost...
22.5.3 Paroxysmal nocturnal haemoglobinuria 5348 L
22.5.3 Paroxysmal nocturnal haemoglobinuria 5348 Lucio Luzzatto section 22 Haematological disorders 5348 There are anecdotal reports on the use of monoclonal antibody therapy with alemtuzumab (anti-CD52) and rituximab (anti- CD20). Alemtuzumab has been used...
22.6 Erythroid disorders 5354 22.6.1 Erythropoiesi
22.6 Erythroid disorders 5354 22.6.1 Erythropoiesis 5354 Vijay G. Sankaran CONTENTS 22.6.1 Erythropoiesis 5354 Vijay G. Sankaran 22.6.2 Anaemia: pathophysiology, classification, and clinical features 5359 David J. Weatherall and Chris Hatton 22.6.3 Anaemi...
22.6.10 Erythrocyte enzymopathies 5463 Alberto Zan
22.6.10 Erythrocyte enzymopathies 5463 Alberto Zanella and Paola Bianchi 22.6.10 Erythrocyte enzymopathies 5463 gene, with dominant inheritance). In both cases, abnormal cation flux results. Diagnosis of these rare conditions rests on the iden- tification of ...
22.6.11 Glucose- 6- phosphate dehydrogenase defici
22.6.11 Glucose- 6- phosphate dehydrogenase deficiency 5472 Lucio Luzzatto section 22 Haematological disorders 5472 Meza NW, et al. (2009). Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. Mol Ther, 17, 2000–9. Pey AL, ...