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References 542 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 4 ■ ■Benzodiazepine misuse is frequently seen in multisubstance misuse where opioids may be the primary drug of dependence. ■ ■Consider cognitive behavioural therapy (CBT) when withdrawi...

Drug-induced excited state

Pathophysiology

Identification

Management Addictions and substance misuse CHAPTER 4 Drug-­induced excited state A drug-­induced excited state is an under-­recognised and potentially life-­threatening syndrome of agitation, aggression and dysregulated physiological responses.1 Illicit drugs ...

Outcomes

References 544 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 4 heat generation and catecholamine release. There is evidence to support intramuscular use of benzodiazepines (including lorazepam and midazolam13), antipsychotics (including haloperido...

Interactions between illicit drugs and prescribed psychotropic drugs Addictions and substance misuse CHAPTER 4 Interactions between illicit drugs and prescribed psychotropic drugs Interactions between drugs of misuse and prescribed psychotropics are common, no...

References 548 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 4 References Zapelini do Nascimento D, et  al. Potential psychotropic drug interactions among drug-­dependent people. J Psychoactive Drugs 2021; 53:168–176. Vocci FJ, et al. Medication ...

Drugs of misuse – a summary Addictions and substance misuse CHAPTER 4 Drugs of misuse – a summary Urine testing for illicit drugs is routine on many psychiatric wards and in out-­patient settings and doctors’ offices. It is important to be aware of the duratio...

References Addictions and substance misuse CHAPTER 4 References Couchman L, et al. Amisulpride and sulpiride interfere in the CEDIA DAU buprenorphine test. Ann Clin Psychiatry 2008; 45 Suppl 1. Merative US L.P. Micromedex. 2024; https://www.micromedexsolution...

Substance misuse in pregnancy 554 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 4 Substance misuse in pregnancy Substance misuse in pregnancy has a wide range of adverse obstetric and fetal outcomes (Table 4.27). The overall quality of evidence is...

References Addictions and substance misuse CHAPTER 4 References UK Health Security Agency. UK Teratology Information Service. 2024; https://uktis.org. National Institute for Health and Care Excellence. Pregnancy and complex social factors: a model for service...

Gambling disorder

References 560 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 4 Gambling disorder At the time of writing, no medicines are licensed for the treatment of problem ­gambling. However, international guidelines and draft NICE guidance recommend naltrexo...

Principles of prescribing practice in childhood and adolescence The Maudsley® Prescribing Guidelines in Psychiatry, Fifteenth Edition. David M. Taylor, Thomas R. E. Barnes and Allan H. Young. © 2025 David M. Taylor. Published 2025 by John Wiley & Sons Ltd. Cha...

References Prescribing in children and adolescents CHAPTER 5 References Gerlach M, et al. Psychiatric Drugs in Children and Adolescents. Basic Pharmacology and Practical Applications. Vienna: Springer-­Verlag; Turner M, et al. Prescribing Medicines for Child...

Depression in children and adolescents