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55 - References

References

542 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 4 ■ ■Benzodiazepine misuse is frequently seen in multisubstance misuse where opioids may be the primary drug of dependence. ■ ■Consider cognitive behavioural therapy (CBT) when withdrawing from benzodiazepines. More detailed information on benzodiazepine withdrawal is given in The Maudsley Deprescribing Guidelines.13 References

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  9. Darker CD, et al. Psychosocial interventions for benzodiazepine harmful use, abuse or dependence. Cochrane Database Syst Rev 2015; 5:CD009652.
  10. Soni A, et al. Feasibility and effectiveness of deprescribing benzodiazepines and Z-­drugs: systematic review and meta-­analysis. Addiction 2023; 118:7–16.
  11. Gould RL, et al. Interventions for reducing benzodiazepine use in older people: meta-­analysis of randomised controlled trials. Br J Psychiatry 2014; 204:98–107.
  12. Baandrup L, et al. Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users. Cochrane Database Syst Rev 2018; 3:CD011481.
  13. Horowitz M, et  al. The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-­drugs. Oxford: Wiley-­Blackwell; 2024. Table 4.24  Typical diazepam withdrawal schedule for iatrogenic dependence. Week Dose Baseline 30mg/day Week 2 25mg/day Week 4 20mg/day Week 6 18mg/day Week 8 16mg/day Week 10 14mg/day Week 12 12mg/day Week 14 10mg/day Then reduce by 2mg/day every 2 weeks if tolerated.