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02 - General principles
General principles The Maudsley® Prescribing Guidelines in Psychiatry, Fifteenth Edition. David M. Taylor, Thomas R. E. Barnes and Allan H. Young. © 2025 David M. Taylor. Published 2025 by John Wiley & Sons Ltd. General principles in prescribing in older adult...
03 - Drug interactions
Drug interactions 628 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 and diuretics). Older people demonstrate an exaggerated response to central nervous system (CNS)-active drugs such as benzodiazepines and opioids. This is partly because of an ...
04 - Administering medicines in foodstuffs1316
Administering medicines in foodstuffs13–16
05 - References
References Prescribing in older people CHAPTER 6 Changes in the way these drugs are handled in older people and the greater chance of interaction with other drugs mean that toxicity and therapeutic failure are more likely. These drugs can be used safely but ex...
06 - Dementia
Dementia
07 - Alzheimers disease (AD)
Alzheimer’s disease (AD) 630 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 Dementia Dementia is a progressive syndrome affecting around 5% of those aged over 65 years, rising to 20% in the over 80s. The disorder is characterised by cognitive dec...
08 - Vascular dementia (VaD)
Vascular dementia (VaD) Prescribing in older people CHAPTER 6 24.0% and 31.4% of treated individuals, respectively.113,114 Donanemab is, at the time of writing, undergoing a full evaluation by the FDA and NICE. The development of three monoclonal antibodies, g...
09 - Dementia with Lewy bodies (DLB)
Dementia with Lewy bodies (DLB)
10 - Mild cognitive impairment (MCI)
Mild cognitive impairment (MCI)
11 - Other dementias
Other dementias 648 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 Dementia with Lewy bodies (DLB) DLB may account for 15–25% of cases of dementia. Characteristic symptoms are dementia with fluctuation of cognitive ability, early and persistent v...
12 - Summary of clinical practice guidance for use
Summary of clinical practice guidance for use of anti-dementia drugs Prescribing in older people CHAPTER 6 genetics and biomarker analysis, much has been discovered about the phenomena underlying frontotemporal lobar degeneration. This has allowed the design o...
13 - References
References 650 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 References National Institute for Health and Care Excellence. Dementia: assessment, management and support for people living with dementia and their carers. NICE Guideline [NG97]. 201...
14 - Safer prescribing for physical conditions in
Safer prescribing for physical conditions in dementia
15 - Anticholinergic drugs
Anticholinergic drugs 654 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 Safer prescribing for physical conditions in dementia People with dementia are susceptible to cognitive adverse effects of drugs. Drugs may affect cognition through their ac...
16 - Safety of physical health medication prescrib
Safety of physical health medication prescribed in dementia 658 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 Safety of physical health medication prescribed in dementia Anticholinergic drugs used in urinary incontinence Oxybutynin penetrates th...
17 - References
References 664 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 6 References Sink KM, et al. Dual use of bladder anticholinergics and cholinesterase inhibitors: long-term functional and cognitive outcomes. J Am Geriatr Soc 2008; 56:847–853. Ruxton ...
18 - Management of behavioural and psychological s
Management of behavioural and psychological symptoms of dementia (BPSD)
19 - Non drug measures
Non-drug measures Prescribing in older people CHAPTER 6 Management of behavioural and psychological symptoms of dementia (BPSD) Behavioural and psychological symptoms of dementia (BPSD) cover a range of difficulties including aggression, agitation, vocalisatio...