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Immunosuppressive regimen for renal transplantation Immunosuppression for renal transplantation g...

INTRODUCTION Successful solid organ transplantation represents one of the great medical advances...

KIDNEY TRANSPLANTATION End-stage renal disease The incidence of end-stage renal disease (ESRD) i...

Hypothermic machine perfusion The transplant organ is placed in a sterile chamber and cold preser...

IMMUNOLOGY OF TRANSPLANT REJECTION ABO blood groups ABO blood group antigens are glycoproteins wi...

IMMUNOSUPPRESSION Modern immunosuppression is so e ff ective that acute rejec - tion rates of 10–...

FURTHER READING Bolton EM, Bradley JA. Principles of transplant immunology and immunosuppressive...

HLA matching Allograft rejection is directed against human leukocyte anti gens (HLAs). These are ...

Hyperacute rejection Hyperacute rejection is extremely rare. It can result from an inadvertent AB...

Dual kidney transplantation This involves the transplantation of a pair of marginal quality kid...

Early postoperative course Accurate fluid and electrolyte balance are maintained with the help of ...

Evaluation of the deceased donor The absolute contraindications to organ donation include active ...

Calcineurin inhibitors (ciclosporin and tacrolimus) The calcineurin inhibitors (CNIs) are the mai...

Corticosteroids These are potent anti-inflammatory agents that have wide-ranging e ff ects on the i...

Delayed renal allograft function DGF is defined as the need for dialysis in the first 7 days post t...

Donation after circulatory death Donation after circulatory death describes the recovery of organ...

Acute cell-mediated rejection In the era of modern immunosuppressive drugs, the incidence of ac...

Antigen presentation in transplantation There are two main types of antigen presentation to T ly...

Antiproliferative agents (azathioprine and mycophenolic acid) These drugs are antiproliferative a...

Acute antibody-mediated rejection Acute antibody-mediated rejection (AMR) occurs in <5% of renal...