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11 - PART 4 Oncology and Hematology

01 - SECTION 1 Neoplastic Disorders

SECTION 1 Neoplastic Disorders Section 1 Neoplastic Disorders Dan L. Longo Approach to the Patie...

02 - 73 Approach to the Patient with Cancer

73 Approach to the Patient with Cancer Section 1 Neoplastic Disorders Dan L. Longo Approach to t...

03 - 74 Symptom Control in Patients with Cancer

74 Symptom Control in Patients with Cancer Charles L. Loprinzi, Thomas J. Smith Symptom Control i...

04 - 75 Prevention and Early Detection of Cancer

75 Prevention and Early Detection of Cancer Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kra...

05 - 76 Cancer Genetics

76 Cancer Genetics Manson JE et al: Vitamin D supplements and prevention of cancer and cardiovasc...

06 - 77 Cancer Cell Biology

77 Cancer Cell Biology obstacle. For example, when a tumor-suppressor gene is inactivated, some d...

07 - 78 Principles of Cancer Treatment

78 Principles of Cancer Treatment proteins, and many are in clinical development for cancer thera...

08 - 79 Infections in Patients with Cancer

79 Infections in Patients with Cancer ■ ■DIARRHEA Similar to the vomiting syndromes, chemotherapy...

09 - 80 Oncologic Emergencies

80 Oncologic Emergencies reactivation is advised in the majority of patients with hematologic mal...

10 - 81 Cancer of the Skin

81 Cancer of the Skin Premedication with histamine H1 and H2 receptor antagonists and glucocortic...

11 - 82 Head and Neck Cancer

82 Head and Neck Cancer histologically by the presence of Paget cells. These tumors present as mo...

12 - 83 Neoplasms of the Lung

83 Neoplasms of the Lung However, immunotherapies have proven to be of value in this setting. In ...

13 - 84 Breast Cancer

84 Breast Cancer TABLE 83-14  Staging Thymic Tumors MASAOKA STAGE DEFINITION I Grossly and micros...

14 - 85 Upper Gastrointestinal Tract Cancers

85 Upper Gastrointestinal Tract Cancers Many chemotherapeutic agents are active in metastatic bre...

15 - 86 Colorectal Cancer

86 Colorectal Cancer ■ ■FURTHER READING Ben-Aharon I et al: Early-onset cancer in the gastrointes...

16 - 87 Tumors of the Liver and Biliary Tree

87 Tumors of the Liver and Biliary Tree Rarely, RET fusions and TRK fusions can be seen in patien...

17 - 88 Pancreatic Cancer

88 Pancreatic Cancer Eileen M. O’Reilly, Andrew M. Lowy, Daniel D. Von Hoff Pancreatic Cancer Pan...

18 - 89 Gastrointestinal Neuroendocrine Tumors

89 Gastrointestinal Neuroendocrine Tumors TABLE 88-4  Combination Chemotherapy Regimens That Have...

19 - 90 Renal Cell Carcinoma

90 Renal Cell Carcinoma Dasari A et al: Trends in the incidence, prevalence, and survival out­ co...

20 - 91 Cancer of the Bladder and Urinary Tract

91 Cancer of the Bladder and Urinary Tract TABLE 90-3  Commonly Used Systemic Regimens for Metast...

21 - 92 Benign and Malignant Diseases of the Prostate

92 Benign and Malignant Diseases of the Prostate Siegel RL et al: Cancer statistics, 2023. CA Can...

22 - 93 Testicular Cancer

93 Testicular Cancer following patients as they are treated with various forms of therapy. Asympt...

23 - 94 Gynecologic Malignancies

94 Gynecologic Malignancies Patients in first relapse may be treated with either conventionaldose...

24 - 95 Primary and Metastatic Tumors of the Nervous System

95 Primary and Metastatic Tumors of the Nervous System Mary Jane Lim-Fat, Patrick Y. Wen Primary ...

25 - 96 Soft Tissue and Bone Sarcomas and Bone Metastases

96 Soft Tissue and Bone Sarcomas and Bone Metastases Lamba N et al: Epidemiology of brain metasta...

26 - 97 Carcinoma of Unknown Primary

97 Carcinoma of Unknown Primary osteoporosis, the cortical bone may be preserved, whereas cortica...

27 - 98 Paraneoplastic Syndromes- Endocrinologic-Hematologic

98 Paraneoplastic Syndromes: Endocrinologic/Hematologic ■ ■FURTHER READING Gatalica Z et al: Comp...

28 - 99 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis

99 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis Josep Dalmau, Francesc Graus P...

30 - SECTION 2 Hematopoietic Disorders

SECTION 2 Hematopoietic Disorders traditionally been performed by oncologists, but the magnitude ...

31 - 101 Hematopoietic Stem Cells

101 Hematopoietic Stem Cells traditionally been performed by oncologists, but the magnitude of th...

33 - 103 Disorders of Hemoglobin

103 Disorders of Hemoglobin ■ ■TREATMENT Treatment of the underlying disorder controls anemia of ...

34 - 104 Megaloblastic Anemias

104 Megaloblastic Anemias Unexpected low O2 saturation by pulse oximetry (SpO2) with nor­ mal O2 ...

35 - 105 Hemolytic Anemias

105 Hemolytic Anemias Lucio Luzzatto, Lucia De Franceschi Hemolytic Anemias ■ ■DEFINITIONS Turnov...

36 - 106 Anemia Due to Acute Blood Loss

106 Anemia Due to Acute Blood Loss Loirat C et al: An international consensus approach to the man...

38 - 108 Polycythemia Vera and Other Myeloproliferative Neoplasms

108 Polycythemia Vera and Other Myeloproliferative Neoplasms anti-CD52 monoclonal antibody alemtu...

39 - 109 Acute Myeloid Leukemia

109 Acute Myeloid Leukemia were more effective than anagrelide and aspirin for prevention of TIA ...

40 - 110 Chronic Myeloid Leukemia

110 Chronic Myeloid Leukemia alone frequently died from DIC induced by the release of gran­ ule c...

41 - 111 Acute Lymphoid Leukemia

111 Acute Lymphoid Leukemia Dieter Hoelzer Acute Lymphoid Leukemia In acute lymphoblastic leukemi...

42 - 112 Chronic Lymphocytic Leukemia

112 Chronic Lymphocytic Leukemia least eight or more cycles. This leads to a significant increase...

43 - 113 Non-Hodgkin’s Lymphoma

113 Non-Hodgkin’s Lymphoma Caron A. Jacobson, Dan L. Longo Non-Hodgkin’s Lymphoma Non-Hodgkin’s l...

44 - 114 Hodgkin’s Lymphoma

114 Hodgkin’s Lymphoma FIGURE 113-7  Adult T-cell leukemia/lymphoma. Peripheral blood smear showi...

45 - 115 Less Common Lymphoid and Myeloid Malignancies

115 Less Common Lymphoid and Myeloid Malignancies SURVIVORSHIP Because of the very high cure rate...

46 - 116 Plasma Cell Disorders

116 Plasma Cell Disorders Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson Plasma Cell Disorde...

47 - 117 Amyloidosis

117 Amyloidosis the assembly of light and heavy chains because they appear to contain both in the...

48 - 118 Transfusion Therapy and Biology

118 Transfusion Therapy and Biology Pierre Tiberghien, Olivier Garraud, Jacques Chiaroni Transfus...

49 - 119 Hematopoietic Cell Transplantation

119 Hematopoietic Cell Transplantation Frederick R. Appelbaum Hematopoietic Cell Transplantation ...

50 - SECTION 3 Disorders of Hemostasis

SECTION 3 Disorders of Hemostasis Section 3 Disorders of Hemostasis Barbara A. Konkle Disorders ...

51 - 120 Disorders of Platelets and Vessel Wall

120 Disorders of Platelets and Vessel Wall Section 3 Disorders of Hemostasis Barbara A. Konkle D...

52 - 121 Coagulation Disorders

121 Coagulation Disorders Gomez K: Advances in the diagnosis of heritable platelet disorders. Blo...

53 - 122 Arterial and Venous Thrombosis

122 Arterial and Venous Thrombosis Jane E. Freedman, Joseph Loscalzo Arterial and Venous Thrombos...

54 - 123 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

123 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs risk remains low (1 in 6000). The relativ...