12 - 42_Pharmacokinetics

1. Principles of pharmacokinetics

A. Absorption

Oral administration © SPMM Course Principles of pharmacokinetics Pharmacokinetics refers to the ...

Intramuscular administration

Intravenous routes © SPMM Course Size of drug particle Solubility of the drug Properties of inte...

B. Permeation: © SPMM Course B. Permeation: Permeation of a drug is defined as the lipid membrane...

C. Distribution: © SPMM Course C. Distribution: Distribution of a drug refers to ‘where’ in the b...

Blood-brain barrier © SPMM Course (Chadwick et al., 2005). Protein binding interactions become re...

D. Bioavailability: © SPMM Course D. Bioavailability: Bioavailability refers to how much of an ad...

E. Metabolism of drugs: © SPMM Course for lithium carbonate or Clozaril vs. zaponex for clozapine...

F. Excretion: © SPMM Course F. Excretion: The major routes of drug excretion are via urine, faece...

G. Elimination kinetics: © SPMM Course fall in the plasma drug concentration, which is caused by ...

2. Indices of safety and efficacy: © SPMM Course 2. Indices of safety and efficacy: Quantal or do...

3. Variables affecting pharmacokinetics:

A. Changes in the elderly © SPMM Course 3. Variables affecting pharmacokinetics: A. Changes in th...

B. Changes in neonates:

C. Changes in pregnancy:

D. Changes with renal impairment: © SPMM Course may be 600ml/min as compared to 1200ml/min in you...

4. Clinically relevant kinetics and interactions:

A. Tricyclic antidepressants: © SPMM Course 4. Clinically relevant kinetics and interactions: A. ...

B. SSRIs © SPMM Course B. SSRIs  The SSRIs are rapidly absorbed. Sertraline availability may be ...

C. Other antidepressants © SPMM Course C. Other antidepressants The MAOIs are all rapidly absorbe...

Terms used to describe therapeutic effects of antidepressants © SPMM Course compared to buspirone...

D. Mood stabilisers © SPMM Course D. Mood stabilisers Lithium is orally well absorbed but not met...

E. Typical antipsychotics: © SPMM Course to about 75mL/min. The active CBZ-10,11-epoxide (CBZ-E) ...

Depot atypicals © SPMM Course  Lipid storage and brain retention are significant; depot forms of...

F. Atypical antipsychotics: © SPMM Course F. Atypical antipsychotics: All atypicals are orally we...

G. Antidementia drugs:

H. Other drugs: © SPMM Course be supplemented with oral risperidone for 3 weeks. Requires refrige...

Benzodiazepines: © SPMM Course Benzodiazepines: Drug Duration of action Effect Diazepam, chlordia...