09 - References

References

Prescribing in children and adolescents CHAPTER 5 likely to outweigh these risks in moderate to severe depression. Nonetheless, it bears repeating that the risk of suicide should be very carefully monitored.3,4,6,31 ■ ■Activation and manic switch Activation adverse effects of antidepressant ­medication –­ including increased activity, restlessness and ­agitation –­ occur more commonly in children than in adolescents or adults. These effects, including mild symptoms, may occur in about 10% of children with depression taking SSRIs.54,55 They are usually a transient response to starting medication or increasing dose and should be differentiated from manic switch. Conversion to mania is rarer but is observed more often in young people taking antidepressants than in adults.56,57 However, there is no clear evidence that this switch is caused by antidepressants. References

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