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150 - What is the mechanism

What is the mechanism?

Depression and anxiety disorders CHAPTER 3 References

  1. Schieveld JNM, et al. On benzodiazepines, paradoxical agitation, hyperactive delirium, and chloride homeostasis. Crit Care Med 2018; 46:1558–1559.
  2. Dietch JT, et al. Aggressive dyscontrol in patients treated with benzodiazepines. J Clin Psychiatry 1988; 49:184–188.
  3. Rothschild AJ, et al. Comparison of the frequency of behavioral disinhibition on alprazolam, clonazepam, or no benzodiazepine in hospitalized psychiatric patients. J Clin Psychopharmacol 2000; 20:7–11.
  4. Bramness JG, et al. Flunitrazepam: psychomotor impairment, agitation and paradoxical reactions. Forensic Sci Int 2006; 159:83–91.
  5. O’Sullivan GH, et al. Safety and side-­effects of alprazolam: controlled study in agoraphobia with panic disorder. Br J Psychiatry 1994; 165:79–86.
  6. Gardner DL, et al. Alprazolam-­induced dyscontrol in borderline personality disorder. Am J Psychiatry 1985; 142:98–100.
  7. Matsumoto T, et  al. Prevalence and characteristics of disinhibition during bronchoscopy with midazolam. Respir Investig 2022; 60:345–354.
  8. Albrecht B, et al. Motivational drive and alprazolam misuse: a recipe for aggression? Psychiatry Res 2016; 240:381–389.
  9. Albrecht B, et al. Benzodiazepine use and aggressive behaviour: a systematic review. Aust N Z J Psychiatry 2014; 48:1096–1114.
  10. Sabe M, et al. Zolpidem stimulant effect: induced mania case report and systematic review of cases. Prog Neuropsychopharmacol Biol Psychiatry 2019; 94:109643.
  11. Poceta JS. Zolpidem ingestion, automatisms, and sleep driving: a clinical and legal case series. J Clin Sleep Med 2011; 7:632–638.
  12. Pressman MR. Sleep driving: sleepwalking variant or misuse of z-­drugs? Sleep Med Rev 2011; 15:285–292.
  13. Daley C, et al. ‘I did what?’ Zolpidem and the courts. J Am Acad Psychiatry Law 2011; 39:535–542.
  14. Bond AJ. Drug-­induced behavioural disinhibition incidence, mechanisms and therapeutic implications. CNS Drugs 1998; 9:41–57.
  15. Hakimi Y, et al. Paradoxical adverse drug reactions: descriptive analysis of French reports. Euro J Clin Pharmacol 2020; 76:1169–1174.
  16. Hawkridge SM, et al. A risk–benefit assessment of pharmacotherapy for anxiety disorders in children and adolescents. Drug Saf 1998; 19:283–297.
  17. Kandemir H, et al. Behavioral disinhibition, suicidal ideation, and self-­mutilation related to clonazepam. J Child Adolesc Psychopharmacol 2008; 18:409.
  18. Daderman AM, et al. Flunitrazepam (Rohypnol) abuse in combination with alcohol causes premeditated, grievous violence in male juvenile offenders. J Am Acad Psychiatry Law 1999; 27:83–99.
  19. van der Bijl P, et al. Disinhibitory reactions to benzodiazepines: a review. J Oral Maxillofac Surg 1991; 49:519–523.
  20. McKenzie WS, et al. Paradoxical reaction following administration of a benzodiazepine. J Oral Maxillofac Surg 2010; 68:3034–3036.
  21. Wilson KE, et  al. Complications associated with intravenous midazolam sedation in anxious dental patients. Prim Dent Care 2011; 18:161–166.
  22. Short TG, et  al. Paradoxical reactions to benzodiazepines: a genetically determined phenomenon? Anaesth Intensive Care 1987; 15:330–331.
  23. Weisman AM, et  al. Effects of clorazepate, diazepam, and oxazepam on a laboratory measurement of aggression in men. Int Clin Psychopharmacol 1998; 13:183–188.
  24. Blair RJ, et al. Selective impairment in the recognition of anger induced by diazepam. Psychopharmacology 1999; 147:335–338.
  25. Wallace PS, et al. Reduction of appeasement-­related affect as a concomitant of diazepam-­induced aggression: evidence for a link between aggression and the expression of self-­conscious emotions. Aggress Behav 2009; 35:203–212.
  26. Tae CH, et al. Paradoxical reaction to midazolam in patients undergoing endoscopy under sedation: incidence, risk factors and the effect of flumazenil. Dig Liver Dis 2014; 46:710–715.
  27. Bond AJ, et al. Behavioural aggression in panic disorder after 8 weeks’ treatment with alprazolam. J Affect Disord 1995; 35:117–123.
  28. Penninga EI, et al. Adverse events associated with flumazenil treatment for the management of suspected benzodiazepine intoxication: a systematic review with meta-­analyses of randomised trials. Basic Clin Pharmacol Toxicol 2016; 118:37–44.
  29. Paton C. Benzodiazepines and disinhibition: a review. Psychiatr Bull 2002; 26:460–462.