43 - Relative adverse effects a rough guide

Relative adverse effects – a rough guide

Schizophrenia and related psychoses CHAPTER 1 Relative adverse effects – a rough guide Table 1.7 provides approximate estimates of relative incidence and severity of adverse effects. It serves as a rough guide and does not replace the detailed and referenced sections included elsewhere. For further details, refer to the dedicated sections in this chapter. Other adverse effects not mentioned in this table also occur. Table 1.7  Approximate estimates of relative incidence and severity of adverse effects. Drug Sedation Weight gain Akathisia Parkin­ sonism Anti-­ cholinergic Hypotension Prolactin elevation Prolonged QT interval Amisulpride – + + + – – +++ ++ Aripiprazole – + + – – – – – Asenapine + + + + – – + – Benperidol + + + +++ + + +++ + Blonanserin – – + – – – + – Brexpiprazole – + + – – – – – Cariprazine – + + – – – – – Chlorpromazine +++ ++ + ++ ++ +++ ++ ++ Clozapine +++ +++ – – +++ +++ – +++ Flupentixol + ++ ++ ++ ++ + +++ – Fluphenazine + + ++ +++ + + +++ + Haloperidol + + +++ +++ – + +++ ++ Iloperidone – ++ + + – + – ++ Levomepromazine +++ + + + ++ ++ ++ + Lumateperone ++ – – – – – – – Loxapine ++ + + ++ + ++ +++ – Lurasidone + + + + – – – – Olanzapine +++ +++ + – + + + + Paliperidone + ++ ++ + – ++ +++ + Penfluridol – ++ ++ ++ ++ + +++ ++ Perphenazine + + ++ +++ + + +++ + Pimavanserin – – – – – – – ++ Pimozide + ++ ++ + ++ + +++ +++ Promazine +++ ++ + + ++ ++ + ++ Quetiapine +++ ++ + – + ++ – ++ Risperidone + ++ ++ + – ++ +++ + Sertindole – + + – – +++ – +++ Sulpiride – + + + – – +++ + (Continued)

44 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Drug Sedation Weight gain Akathisia Parkin­ sonism Anti-­ cholinergic Hypotension Prolactin elevation Prolonged QT interval Thiothixene ++ ++ + + ++ ++ + + Trifluoperazine + + + +++ + + +++ ? Xanomeline – – – – – – – + Ziprasidone + – + – – + – ++ Zuclopenthixol ++ ++ ++ ++ ++ + +++ + Key: +++ high incidence/severity, ++ moderate, + low, – very low/zero. Table 1.7  (Continued)