10 - Quick reference for licensed maximum doses

Quick reference for licensed maximum doses

Schizophrenia and related psychoses CHAPTER 1 Quick reference for licensed maximum doses Table 1.2 lists the licensed maximum doses of antipsychotics according to the European Medicines Agency, as of January 2025.1 Table 1.2  Maximum doses of antipsychotics according to European Medicines Agency labelling.1 Drug Maximum dose FGAs – oral Chlorpromazine 1000mg/day Flupentixol 18mg/day Haloperidol 20mg/day Levomepromazine 1200mg/day Pericyazine 300mg/day Perphenazine 24mg/day (64mg/day hospitalised patients) Pimozide 20mg/day Sulpiride 2400mg/day Trifluoperazine 20mg/day (maximum dose not formally specified) Zuclopenthixol 150mg/day SGAs – oral Amisulpride 1200mg/day Aripiprazole 30mg/day Asenapine 20mg/day (sublingual) Cariprazine 6mg/day Clozapine 900mg/day Lurasidone 160mg (HCl)/148mg (base)/day Olanzapine 20mg/day Paliperidone 12mg/day Quetiapine 750mg/day schizophrenia (800mg/day MR) 800mg/day bipolar disorder Risperidone 16mg/day Sertindole 24mg/day Long-­acting injections Aripiprazole 1-­monthly 400mg/month (SPC implies ‘every 4 weeks’) Aripiprazole 2-­monthly 960mg/2 months (SPC states ’every 56 days’) Flupentixol decanoate 400mg/week Haloperidol decanoate 300mg/4 weeks Olanzapine pamoate 300mg/2 weeks Paliperidone palmitate 1-­monthly 150mg/month Paliperidone palmitate 3-­monthly 525mg/3 months (Continued)

12 The Maudsley® Prescribing Guidelines in Psychiatry CHAPTER 1 Table 1.3 lists the licensed maximum doses of antipsychotics available outside the EU, according to the US Food and Drug Administration, where available (as of December 2024).2 Table 1.2  (Continued) Drug Maximum dose Paliperidone depot 6-­monthly 1000mg/6 months Risperidone (Consta®) 50mg/2 weeks Risperidone (Okedi®) 100mg/4 weeks Zuclopenthixol decanote 600mg/week Table 1.3  Licensed maximum doses of antipsychotics, according to US Food and Drug Administration labelling, where available.2 Drug Maximum dose FGAs – oral Fluphenazine 40mg/day Thiothixene 60mg/day SGAs – oral Blonanserin* 24mg/day3 Brexpiprazole 4mg/day Iloperidone 24mg/day Lumateperone 42mg/day Molindone 225mg/day Perospirone** 48mg/day Pimavanserin 34mg/day Xanomeline and trospium chloride 250mg/60mg/day Ziprasidone 160mg/day Long-­acting injections Aripiprazole lauroxil (Aristada Initio®)† 675mg Aripiprazole lauroxil (Aristada®) 882mg/month or 1064mg/2 months Fluphenazine decanoate 100mg/14 days Risperidone (Uzedy®) 125mg/month or 250mg/2 months Risperidone (Rykindo®) 50mg/2 weeks Transdermal patch Asenapine 7.6mg/24hr Blonanserin* 80mg/24hr patch4 * Available only in China, Japan and South Korea at the time of writing. ** Available only in Japan at the time of writing. † Used to initiate treatment with Aristada, not for repeat dosing.