α -adrenoceptor antagonists

α -adrenoceptor antagonists

1 The α -adrenoceptor antagonists are commonly used to 1 improve voiding lower urinary tract symptoms (LUTS) in men. Mechanism of action The α -receptors are densely prevalent at the bladder base, 1 bladder neck and proximal urethra in males, and antagonism of these receptors inhibits sympathetic-mediated contraction of the bladder outlet, thereby reducing outlet resistance.