Primary biliary cirrhosis

Primary biliary cirrhosis

As with PSC, patients with primary biliary cirrhosis often pres - ent insidiously with malaise, lethargy and pruritus or abnormal liver function tests prior to becoming clinically jaundice. The condition is largely confined to females and the diagnosis is suggested by circulating anti-smooth muscle antibodies with/ - without liver biopsy . As the condition progresses liver function deteriorates, and portal h ypertension, ascites and variceal tation when a normal lifestyle is not possible.