Serum prostate-specific antigen

Serum prostate-specific antigen

After suitable counselling, measurement of serum PSA may be helpful. Men in whom a diagnosis of early prostate cancer might influence treatment option (such as those under 70 years or those with a positive family history who might be o ff ered radical treatment) should be o ff ered a PSA measurement. If the PSA range is 4–10 /uni00A0 ng/L, a free-to-total PSA ratio of less than 15% should be suspicious of malignancy . Multiparametric magnetic resonance imaging (mpMRI) should be done, which may show a suspicious index lesion. In this situation, transrectal ultrasound (TRUS)-guided or transperineal biopsies should be considered.