Specimen adequacy

Specimen adequacy

There are many reasons for an inadequate specimen. The operator may fail to sample the target organ or lesion or may take a sample that is too small to include or reveal a hetero geneous abnormality . A sample from the centre of a necrotic or ulcerated lesion might include no viable tissue. Superficial biopsies from a carcinoma may fail to distinguish dysplasia ( Figure 11.14 ) from invasive car cinoma. Cautery and crush artefact are sometimes severe enough to impede assessment. Suboptimal laboratory processing can also cause problems with interpretation. Summary box 11.8 Reasons for an inadequate sample /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF

Histology and cytology Failure or inability to sample the intended area Sample too small Sample unrepresentative Non-viable tissue, e.g. ulcer or necrosis Histology Sample too super /f_i cial to detect deeper layers Cautery artefact Crush artefact

Specimen adequacy

There are many reasons for an inadequate specimen. The operator may fail to sample the target organ or lesion or may take a sample that is too small to include or reveal a hetero geneous abnormality . A sample from the centre of a necrotic or ulcerated lesion might include no viable tissue. Superficial biopsies from a carcinoma may fail to distinguish dysplasia ( Figure 11.14 ) from invasive car cinoma. Cautery and crush artefact are sometimes severe enough to impede assessment. Suboptimal laboratory processing can also cause problems with interpretation. Summary box 11.8 Reasons for an inadequate sample /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF

Histology and cytology Failure or inability to sample the intended area Sample too small Sample unrepresentative Non-viable tissue, e.g. ulcer or necrosis Histology Sample too super /f_i cial to detect deeper layers Cautery artefact Crush artefact

Specimen adequacy

There are many reasons for an inadequate specimen. The operator may fail to sample the target organ or lesion or may take a sample that is too small to include or reveal a hetero geneous abnormality . A sample from the centre of a necrotic or ulcerated lesion might include no viable tissue. Superficial biopsies from a carcinoma may fail to distinguish dysplasia ( Figure 11.14 ) from invasive car cinoma. Cautery and crush artefact are sometimes severe enough to impede assessment. Suboptimal laboratory processing can also cause problems with interpretation. Summary box 11.8 Reasons for an inadequate sample /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF

Histology and cytology Failure or inability to sample the intended area Sample too small Sample unrepresentative Non-viable tissue, e.g. ulcer or necrosis Histology Sample too super /f_i cial to detect deeper layers Cautery artefact Crush artefact