BENIGN PROSTATIC HYPERPLASIA Aetiology

BENIGN PROSTATIC HYPERPLASIA Aetiology

Hormones Serum testosterone levels slowly but significantly decrease with advancing age; however, levels of oestrogenic steroids are not decreased equally . According to this theory , the prostate enlarges because of increased oestrogenic e ff ects. It is likely that the secretion of intermediate peptide growth factors plays a part in the development of benign prostatic hyper- plasia (BPH). Metabolic syndrome and hereditary factors have also been implicated in its development. Summary box 84.1 Benign prostatic hyperplasia (BPH) /uni25CF /uni25CF

Occurs in men over 50 years of age; by the age of 60 years, 50% of men have histological evidence of BPH It is a common cause of signi /f_i cant lower urinary tract symptoms (LUTS) in men and the most common cause of bladder out /f_l ow obstruction (BOO) in men >70 years of age