RESPONSE

RESPONSE

It is important to recognise that, in general or population terms, the metabolic response to injury is graded: the more severe - the injury , the greater the response ( Figure 1.1 ). This concept applies not only to physiological and metabolic changes but - also to immunological changes and other sequelae. Thus, following major elective surgery , there may be a transient and - modest rise in temperature, heart ra te, respiratory rate, energy expenditure and peripheral white cell count. Following major trauma, emergency surgery , sepsis or burns, these changes are accentuated, resulting in SIRS, with hypermetabolism, - marked catabolism, shock and even MODS. However, genetic variability also plays a key role in determining the intensity of the inflammatory response, with some individual patients responding much more dramatically than others to apparently similar conditions. RESPONSE

It is important to recognise that, in general or population terms, the metabolic response to injury is graded: the more severe - the injury , the greater the response ( Figure 1.1 ). This concept applies not only to physiological and metabolic changes but - also to immunological changes and other sequelae. Thus, following major elective surgery , there may be a transient and - modest rise in temperature, heart ra te, respiratory rate, energy expenditure and peripheral white cell count. Following major trauma, emergency surgery , sepsis or burns, these changes are accentuated, resulting in SIRS, with hypermetabolism, - marked catabolism, shock and even MODS. However, genetic variability also plays a key role in determining the intensity of the inflammatory response, with some individual patients responding much more dramatically than others to apparently similar conditions. RESPONSE

It is important to recognise that, in general or population terms, the metabolic response to injury is graded: the more severe - the injury , the greater the response ( Figure 1.1 ). This concept applies not only to physiological and metabolic changes but - also to immunological changes and other sequelae. Thus, following major elective surgery , there may be a transient and - modest rise in temperature, heart ra te, respiratory rate, energy expenditure and peripheral white cell count. Following major trauma, emergency surgery , sepsis or burns, these changes are accentuated, resulting in SIRS, with hypermetabolism, - marked catabolism, shock and even MODS. However, genetic variability also plays a key role in determining the intensity of the inflammatory response, with some individual patients responding much more dramatically than others to apparently similar conditions.