Prostate-specific antigen

Prostate-specific antigen

This is discussed earlier in this chapter. It is good at follow ing the course of advanced disease; however, it is lacking in sensitivity and specificity in the diagnosis of early localised prostate cancer. Nevertheless, the finding of a PSA >10 /uni00A0 ng/mL is suggestive of cancer and >35 /uni00A0 ng/mL is almost diagnostic of advanced prostate cancer, in the absence of active urinary tract infection. A decrease in PSA to the normal range following hormonal ablation is a good prognostic sign. Following radical Sir James Paget , 1814–1899, English surgeon and pathologist, best known for his description of Paget’s disease of the bone. levels (the limit for detection for modern supersensitive assays is <0.03 /uni00A0 ng/mL).