Normothermic machine perfusion

Normothermic machine perfusion

Normothermic machine perfusion (NMP) utilises the prin - ciples of cardiopulmonary bypass technology and has been used for heart, lung, liver and kidney preservation. Warmed and oxygenated red blood cell-based perfusate is circulated thr ough the donor organ ( Figure 88.5 ). This provides a more physiological environment that restores graft function ex vivo and replenishes depleted ATP levels. NMP restores organ func - tion ex vivo and this allows for assessment of allograft quality and viability . This has led to increased utility of marginal organs that would previously have been discarded on the basis of adverse clinical parameters. NMP may also improve early allograft function and is being developed as a platform for the delivery of pretransplant therapies.

Figure 88.5 Donor kidney undergoing normothermic machine perfu sion.