Parietal cells

Parietal cells

These are found in the body (acid-secreting portion) of the stomach and line the gastric crypts, being more abundant Leopold Auerbach , 1828–1897, Professor of Neuropathology , Breslau, Germany (now Wroc ł aw , Poland). George Meissner , 1829–1905, Professor of Pathology , Gottingen, Germany . . André Latarjet , 1877–1947, anatomist, Lyon, France Guiseppe Grassi , 1913–1980, surgeon, San Giovanni Hospital, Rome, Italy .

‘Criminal’ nerve of Grassi Coeliac branch Posterior nerve Gastric branches Crow's foot Figure 67.3 The histological appearance of a gastric gland. The mucus-secreting cells are seen at the mucosal surface, the eosino

philic parietal cells super /f_i cially in the glands and the basophilic chief cells in the deepest layer.

hydrogen ions that form hydrochloric acid. The hydrogen ions are actively secreted by a hydrogen–potassium-ATPase proton pump, which exchanges intraluminal potassium for hydrogen ions. The potassium ions enter the lumen of the crypts passively , but the hydrogen ions are pumped against an immense concentration gradient (1 000 000:1). Proton + + pump inhibitors (PPIs) act by blocking the H /K ATPase and thereby significantly reduce gastric acid secretion (see Gastric acid secretion ).