Perineural invasion

Perineural invasion

While there is no clear consensus on the criteria for diagnos ing PNI, it is generally described as being present if at least one-third of the circumference of a nerve is surrounded by tumour cells and/or if deposits of tumour are found in any of the three lay ers of the nerve sheath. PNI is a marker for the biological aggressiveness of a tumour and an independent risk factor for cervical metastases, local recurrence and therefore poorer prognosis. Perineural invasion

While there is no clear consensus on the criteria for diagnos ing PNI, it is generally described as being present if at least one-third of the circumference of a nerve is surrounded by tumour cells and/or if deposits of tumour are found in any of the three lay ers of the nerve sheath. PNI is a marker for the biological aggressiveness of a tumour and an independent risk factor for cervical metastases, local recurrence and therefore poorer prognosis.