Metastases

Metastases

As outlined previously , HPV-negative cervical node metastases are associated with decreased overall and disease-specific survival. While skip metastases have been described, most OCSCC metastases occur in levels I and II of the neck. ENE occurs when the capsule is breached and this is now accounted for in the UICC/AJCC eighth edition TNM staging system. Distant metastases are rare in OCSCCs, with reported rates of 2–9%, and are associated most commonly with ENE and bilateral neck disease. Metastases

As outlined previously , HPV-negative cervical node metastases are associated with decreased overall and disease-specific survival. While skip metastases have been described, most OCSCC metastases occur in levels I and II of the neck. ENE occurs when the capsule is breached and this is now accounted for in the UICC/AJCC eighth edition TNM staging system. Distant metastases are rare in OCSCCs, with reported rates of 2–9%, and are associated most commonly with ENE and bilateral neck disease.