Metabolic response to trauma and sepsis

Metabolic response to trauma and sepsis

This is described in greater detail in Chapter 1 , and covered briefly in Summary box 25.2 . It is important to note that the metabolic response to trauma is influenced by the early and rapid rises in sympathetic nervous system activity and circulating catecholamines and elevated levels of glucocorticoids, glucagon and gr owth hormone, as well as insulin. Energy requirements often remain increased to allow tissue repair and inflammatory cell function. Elevated stress hormone levels can lead to net catabolism of tissue protein and thus a negative nitrogen balance. Ketone body production and utilisation may be impaired in the response to trauma, further exacerbating the catabolic response and protein breakdown. Metabolic response to trauma and sepsis

This is described in greater detail in Chapter 1 , and covered briefly in Summary box 25.2 . It is important to note that the metabolic response to trauma is influenced by the early and rapid rises in sympathetic nervous system activity and circulating catecholamines and elevated levels of glucocorticoids, glucagon and gr owth hormone, as well as insulin. Energy requirements often remain increased to allow tissue repair and inflammatory cell function. Elevated stress hormone levels can lead to net catabolism of tissue protein and thus a negative nitrogen balance. Ketone body production and utilisation may be impaired in the response to trauma, further exacerbating the catabolic response and protein breakdown. Metabolic response to trauma and sepsis

This is described in greater detail in Chapter 1 , and covered briefly in Summary box 25.2 . It is important to note that the metabolic response to trauma is influenced by the early and rapid rises in sympathetic nervous system activity and circulating catecholamines and elevated levels of glucocorticoids, glucagon and gr owth hormone, as well as insulin. Energy requirements often remain increased to allow tissue repair and inflammatory cell function. Elevated stress hormone levels can lead to net catabolism of tissue protein and thus a negative nitrogen balance. Ketone body production and utilisation may be impaired in the response to trauma, further exacerbating the catabolic response and protein breakdown.