Premalignant lesions Extramammary Paget’s disease

Premalignant lesions Extramammary Paget’s disease (intraepidermal adenocarcinoma)

This occurs in cutaneous sites that are rich in apocrine glands such as the axillae and the genital and perianal regions. Approximately 25% are associated with an underlying Sir James Paget , 1814–1899, surgeon, St Bartholomew’s Hospital, London, UK. or invasive adenocarcinoma. Early skin changes are subtle and may present as an eczematous lesion or intertrigo. Surgi - cal excision forms the basis of treatment, with up to 20% demonstrating invasive disease after pathology assessment ( Figure 45.27 ).

Figure 45.27 Extramammary Paget’s disease involving the perineum (courtesy of St John’s Institute for Dermatology, London, UK).