INFLAMMATION AND CIRCULATORY CHANGES

INFLAMMATION AND CIRCULATORY CHANGES

The circulatory changes initiated by a burn injury are complex and multifactorial, originating from both the actual injury of burned skin (eschar) and the inflammatory cascade. It is governed by a complex series of events. The release of neuropeptides and the activation of complement are initiated by the stimulation of pain fibres and the alteration of proteins by heat. The activation of Hageman factor initiates a number of protease-driven cascades, altering the arachidonic acid, thrombin and kallikrein pathways. Fluid is lost from capillaries and oedema formation occurs. Summary box 46.6 The shock reaction after burns /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF -

Burns produce an in /f_l ammatory reaction This leads to vastly increased vascular permeability Water, solutes and proteins move from the intra- to the extravascular space The volume of /f_l uid lost is directly proportional to the area of the burn Above 15% of surface area, the loss of /f_l uid produces shock requiring resuscitation

INFLAMMATION AND CIRCULATORY CHANGES

The circulatory changes initiated by a burn injury are complex and multifactorial, originating from both the actual injury of burned skin (eschar) and the inflammatory cascade. It is governed by a complex series of events. The release of neuropeptides and the activation of complement are initiated by the stimulation of pain fibres and the alteration of proteins by heat. The activation of Hageman factor initiates a number of protease-driven cascades, altering the arachidonic acid, thrombin and kallikrein pathways. Fluid is lost from capillaries and oedema formation occurs. Summary box 46.6 The shock reaction after burns /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF -

Burns produce an in /f_l ammatory reaction This leads to vastly increased vascular permeability Water, solutes and proteins move from the intra- to the extravascular space The volume of /f_l uid lost is directly proportional to the area of the burn Above 15% of surface area, the loss of /f_l uid produces shock requiring resuscitation

INFLAMMATION AND CIRCULATORY CHANGES

The circulatory changes initiated by a burn injury are complex and multifactorial, originating from both the actual injury of burned skin (eschar) and the inflammatory cascade. It is governed by a complex series of events. The release of neuropeptides and the activation of complement are initiated by the stimulation of pain fibres and the alteration of proteins by heat. The activation of Hageman factor initiates a number of protease-driven cascades, altering the arachidonic acid, thrombin and kallikrein pathways. Fluid is lost from capillaries and oedema formation occurs. Summary box 46.6 The shock reaction after burns /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF -

Burns produce an in /f_l ammatory reaction This leads to vastly increased vascular permeability Water, solutes and proteins move from the intra- to the extravascular space The volume of /f_l uid lost is directly proportional to the area of the burn Above 15% of surface area, the loss of /f_l uid produces shock requiring resuscitation