The decisive period

The decisive period

There is up to a 4-hour interval before bacterial growth becomes established enough to cause an infection after a breach in the tissues, whether caused by trauma or by surgery . This interval is called the ‘decisive period’ and strategies aimed at preventing infection from taking a hold become ine ff ective after this time period. It is therefore logical that prophylactic antibiotics should be given to cover this period and that they could be - decisive in preventing an infection from developing before bacterial growth takes a hold. The tissue levels of antibiotics during the period when bacterial contamination is likely to occur should be above the minimum inhibitory concentration (MIC90) for the expected pathogens. - The decisive period

There is up to a 4-hour interval before bacterial growth becomes established enough to cause an infection after a breach in the tissues, whether caused by trauma or by surgery . This interval is called the ‘decisive period’ and strategies aimed at preventing infection from taking a hold become ine ff ective after this time period. It is therefore logical that prophylactic antibiotics should be given to cover this period and that they could be - decisive in preventing an infection from developing before bacterial growth takes a hold. The tissue levels of antibiotics during the period when bacterial contamination is likely to occur should be above the minimum inhibitory concentration (MIC90) for the expected pathogens. - The decisive period

There is up to a 4-hour interval before bacterial growth becomes established enough to cause an infection after a breach in the tissues, whether caused by trauma or by surgery . This interval is called the ‘decisive period’ and strategies aimed at preventing infection from taking a hold become ine ff ective after this time period. It is therefore logical that prophylactic antibiotics should be given to cover this period and that they could be - decisive in preventing an infection from developing before bacterial growth takes a hold. The tissue levels of antibiotics during the period when bacterial contamination is likely to occur should be above the minimum inhibitory concentration (MIC90) for the expected pathogens. -