Remodelling

Remodelling

The remodelling phase begins 2–3 weeks after injury and lasts for a year or more. This phase is characterised by maturation of collagen. Type III collagen, which is prevalent during prolif eration, is replaced by stronger type I collagen until the normal skin ratio of 4:1 type I to type III collagen is re-established. The collagen becomes more cross-linked and uniformly aligned. This ma turation of collagen leads to increased tensile strength in the wound, which is maximal 12 weeks post injury and represents approximately 80% of the uninjured skin strength. -

Hair Bacteria Epidermis Oxygen Dermis Subcutaneous layer Collagen Capillary (c) Collagen (b) Proliferation. (c) Remodelling. (Adapted by permission from Springer: Gurtner Nature 2008; 453 : 314–21. 2008).

Remodelling

The remodelling phase begins 2–3 weeks after injury and lasts for a year or more. This phase is characterised by maturation of collagen. Type III collagen, which is prevalent during prolif eration, is replaced by stronger type I collagen until the normal skin ratio of 4:1 type I to type III collagen is re-established. The collagen becomes more cross-linked and uniformly aligned. This ma turation of collagen leads to increased tensile strength in the wound, which is maximal 12 weeks post injury and represents approximately 80% of the uninjured skin strength. -

Hair Bacteria Epidermis Oxygen Dermis Subcutaneous layer Collagen Capillary (c) Collagen (b) Proliferation. (c) Remodelling. (Adapted by permission from Springer: Gurtner Nature 2008; 453 : 314–21. 2008).

Remodelling

The remodelling phase begins 2–3 weeks after injury and lasts for a year or more. This phase is characterised by maturation of collagen. Type III collagen, which is prevalent during prolif eration, is replaced by stronger type I collagen until the normal skin ratio of 4:1 type I to type III collagen is re-established. The collagen becomes more cross-linked and uniformly aligned. This ma turation of collagen leads to increased tensile strength in the wound, which is maximal 12 weeks post injury and represents approximately 80% of the uninjured skin strength. -

Hair Bacteria Epidermis Oxygen Dermis Subcutaneous layer Collagen Capillary (c) Collagen (b) Proliferation. (c) Remodelling. (Adapted by permission from Springer: Gurtner Nature 2008; 453 : 314–21. 2008).