Goblet cell carcinoma

Goblet cell carcinoma

Goblet cell carcinomas (GCCs) of the appendix are a rare vari ant, accounting for less than 5% of appendix tumours. They display both neuroendocrine and glandular di ff erentiation and are not considered true NETs. They ma y be classified as typical GCC or adenocarcinoma ex-GCC (Tang classification), with the latter group carrying a worse prognosis. GCCs display higher grade features than typical NETs and have a greater propensity for nodal and peritoneal dissemination; they should be treated in a similar fashion to appendix adenocarcinoma.