POST-LIVER TRANSPLANT COMPLICATIONS Primary non-fu

POST-LIVER TRANSPLANT COMPLICATIONS Primary non-function

Primary non-function (PNF) is one of the most serious and life-threatening conditions in the immediate post-transplant period. It is defined as an aggravated form of reperfusion injury resulting in irreversible graft failure without detectable /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF /uni25CF

Major side effects Monitoring Blood trough levels Nephrotoxicity Hypertension Diabetogenic (tacrolimus) Gingival hypertrophy/hirsutism (ciclosporin) Increased susceptibility to infection No monitoring Leukopenia Increased susceptibility to infection and cancers Bone marrow suppression with cytopenias, No monitoring pancreatitis Steroid excess (Cushing’s syndrome) No monitoring Impaired wound healing, hyperlipidaemia, Blood trough levels proteinuria, hepatic artery thrombosis

is 4–8% and this is the most common indication for retrans plantation after LT . It is almost always a problem associated with DDLT , but can present in LDLT as well.